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Special Edition Inside
A Publication by The American Society for the Pharmacology and Experimental Therapeutics Pharmacologist Inside: Feature articles from 2014-2015 Special Edition VISIT THE ASPET CAREER CENTER TODAY! WWW.ASPET.ORG/CAREERCENTER/ 4 5 12 21 30 41 WHAT YOU NEED: ASPET’S CAREER CENTER HAS IT 52 Jobseekers: Employers: No registration fee Searchable résumé database Advanced search options Hassle-free posting; online account management tools 61 Sign up for automatic email notifi cations of new jobs that Reach ASPET’s Twitter followers (over 1,000), match your criteria LinkedIn Members (over 2,000), and email subscribers (over 4,000) Free & confi dential résumé posting 71 Post to just ASPET or to entire NHCN network Access to jobs posted on the National Healthcare Career Network (NHCN) Sign up for automatic email notifications of new résumés that match your criteria Career management resources including career tips, coaching, résumé writing, online profi le development, Job activity tracking and much more ASPET is committed to your success: The ASPET Career Center is the best resource for matching job seekers and employers in the pharmacology and related health science fi elds. Our vast range of resources and tools will help you look for jobs, fi nd great employees, and proactively manage 9650 Rockville Pike, Bethesda, MD 20814-3995 your career goals. Main Office: 301.634.7060 www.aspet.org ASPET Career Center Full Page Ad 2015 Updated.indd 1 1/15/2016 3:18:16 PM The Pharmacologist is published and distributed by the American Society for Pharmacology and Experimental Therapeutics. THE PHARMACOLOGIST VISIT THE ASPET CAREER CENTER TODAY! PRODUCTION TEAM Rich Dodenhoff Catherine Fry, PhD WWW.ASPET.ORG/CAREERCENTER/ Judith A. -
Biomérieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics
bioMérieux and Biocartis Sign Strategic Partnership in Molecular Diagnostics Co-development of assays and co-distribution of a fully integrated molecular platform due for launch in 2012 bioMérieux gains exclusive rights in microbiology bioMérieux takes equity stake in Biocartis Marcy l’Etoile (France) and Lausanne (Switzerland) – November 4, 2010 — bioMérieux and Biocartis announced today that they have entered into a strategic agreement to co-develop assays on Biocartis’ fully integrated molecular diagnostics system, which the two companies will co-distribute starting in 2012. Under the agreement, bioMérieux will have worldwide exclusive rights to develop and commercialize microbiology assays on the platform. It will also have access to the platform for certain oncology and theranostics assays. bioMérieux has taken a €9 million equity stake in Biocartis. Biocartis has continued to successfully develop its molecular diagnostics platform, which was acquired from Philips earlier this year. The platform now fully integrates all the steps of a multiplexed molecular assay, from sample-in to data- out, in a sealed disposable cartridge, which avoids any contamination risk. Providing rapid results, the system is able to perform complex tests on a wide variety of samples, including oncology assays on tissue. The Biocartis platform does not require molecular biology experience or infrastructure with highly skilled technicians, and involves only 1-2 minutes hands-on time. Adapted to both small and large labs, the platform is fully scalable and allows random access use. bioMérieux, the world leader in microbiology, will enhance the Biocartis platform’s broad menu with an exclusive line of tests for healthcare-associated infections and sepsis. -
Invitation to Annual Shareholders' Meeting
PRESS RELEASE REGULATED INFORMATION 10 April 2018, 07:00 CEST Invitation to Annual Shareholders’ Meeting Biocartis to propose new board composition Mechelen, Belgium, 10 April 2018 – Biocartis Group NV (the ‘Company’ or ‘Biocartis’), an innovative molecular diagnostics company (Euronext Brussels: BCART), has the honor to invite its shareholders, warrant holders, directors and statutory auditor to its annual shareholders' meeting that will be held on Friday 11 May 2018 at 2:00 p.m. CEST (‘AGM’) at the offices of the Company at Generaal de Wittelaan 11B, 2800 Mechelen, Belgium. The agenda of the AGM includes the proposal for a new board composition based on the appointment of five new independent board members and the re-appointment of three board members whose current mandates will expire at the closing of the AGM. The proposed board composition will allow for a transition towards a board of directors consisting predominantly of independent directors. Subject to the AGM approving the proposed resolutions, the board of directors will be composed as follows as from the closing of the AGM: Five new independent board members: CRBA Management BVBA, represented by Christian Reinaudo (candidate chairman of the board), Ann-Christine Sundell, Harry Glorikian, CLSCO BVBA, represented by Leo Steenbergen, and Luc Gijsens BVBA, represented by Luc Gijsens. Additional information on the proposed new board candidates is included in the explanatory note prepared by the board of directors which can be found on the Company’s website. Four existing board members: Herman Verrelst (CEO) and the re-appointment of three board members, i.e. Peter Piot (independent director), Hilde Windels BVBA, represented by Hilde Windels (non-executive director) and Roald Borré (non-executive director). -
Recommended Methods for the Identification and Analysis of Fentanyl and Its Analogues in Biological Specimens
Recommended methods for the Identification and Analysis of Fentanyl and its Analogues in Biological Specimens MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES Laboratory and Scientific Section UNITED NATIONS OFFICE ON DRUGS AND CRIME Vienna Recommended Methods for the Identification and Analysis of Fentanyl and its Analogues in Biological Specimens MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES UNITED NATIONS Vienna, 2017 Note Operating and experimental conditions are reproduced from the original reference materials, including unpublished methods, validated and used in selected national laboratories as per the list of references. A number of alternative conditions and substitution of named commercial products may provide comparable results in many cases. However, any modification has to be validated before it is integrated into laboratory routines. ST/NAR/53 Original language: English © United Nations, November 2017. All rights reserved. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. Mention of names of firms and commercial products does not imply the endorse- ment of the United Nations. This publication has not been formally edited. Publishing production: English, Publishing and Library Section, United Nations Office at Vienna. Acknowledgements The Laboratory and Scientific Section of the UNODC (LSS, headed by Dr. Justice Tettey) wishes to express its appreciation and thanks to Dr. Barry Logan, Center for Forensic Science Research and Education, at the Fredric Rieders Family Founda- tion and NMS Labs, United States; Amanda L.A. -
Chinese Terracotta Warriors
28 How Paul Janssen’s Drugs Saved the CCHHIINNEESSEE TTEERRRRAACCOOTTTTAA WWAARRRRIIOORRSS Rebecca J. Anderson The Chinese Terracotta Army, dating from approximately the late third century BCE, was discovered on March 29, 1974 to the east of Xi’an in Shaanxi Province, China. Photo: Shutterstock The Pharmacologist • March 2015 29 Chinese museum officials gazed with dismay at their Janssen label (3). These included repackaging and priceless army of ancient statues. For 22 centuries, the distributing generic penicillin and sulfonamides, which terracotta warriors had been protected and preserved in the were increasingly in demand after the war. Paul’s mother, soil of China’s Yellow River valley (1). Now, less than 20 Margriet Fleerakers, served as office manager and also years after these old soldiers emerged from their supervised the production line, including quality control (3). subterranean fortress, many of them had become infected Paul finished high school in 1943. To avoid forced and were suffering from a mysterious rash (2). Local labor in the German factories, he secretly enrolled in archeologists suspected the warriors’ moldy rash was due to college (at the age of 16) with the help of his uncle, Emiel fungi, but they lacked specialized laboratory equipment and Janssen (3). The 12 Jesuit teachers at the Faculté Notre- had only limited expertise to diagnose and treat the ailment. Dame de la Paix in Namur, Belgium, offered intensive The detective who stepped forward to solve this courses in physics, biology, philosophy, and chemistry to a mystery and thwart an archeological catastrophe was an handful of students, including Paul, without the knowledge unlikely hero: a businessman, physician, and scientist who of the German occupiers (2, 3). -
Praesens Foundation, Institut Pasteur, Institut Pasteur De Dakar, University of Nebraska Medical Center, Twist Bioscience Consortium Win Prix Galien Medstartup Award
Praesens Foundation, Institut Pasteur, Institut Pasteur de Dakar, University of Nebraska Medical Center, Twist Bioscience Consortium Win Prix Galien MedStartUp Award October 24, 2019 -- Consortium Developed an Integrated Solution for Better Preparedness and Faster Response to Outbreaks and Epidemics in High-Risk Areas -- BRUSSELS & PARIS & SOUTH SAN FRANCISCO, Calif. & OMAHA, Neb.--(BUSINESS WIRE)--Oct. 24, 2019-- The Praesens Foundation, the Institut Pasteur, the Institut Pasteur de Dakar, University of Nebraska Medical Center and Twist Bioscience Corporation (NASDAQ: TWST) today announced that the consortium is the winner of the Prix Galien MedStartUp award in the category: 'Best Collaboration Dedicated to the Developing or Underserved Populations Worldwide'. The consortium works together to develop, quantify and scale up a range of innovative solutions on the continent of Africa to ensure better preparedness and response to infectious disease outbreaks. This includes assays to rapidly identify pathogens developed for and by low and middle income countries that are not necessarily addressed by the traditional diagnostic players and will benefit the communities that need it most. “Past and recent disease outbreaks of Ebola, SARS, MERS-CoV, Zika and Dengue, have shown that infectious diseases continue to affect many lives while also representing social, economic, and national security threats that can quickly evolve into global health crises1, causing major human suffering and imposing enormous economic damage,” said Dr. Rudi Pauwels, -
Meeting Report: 26Th International Conference on Antiviral Research Q
Antiviral Research 100 (2013) 276–285 Contents lists available at ScienceDirect Antiviral Research journal homepage: www.elsevier.com/locate/antiviral Review Meeting report: 26th International Conference on Antiviral Research q R. Anthony Vere Hodge Vere Hodge Antivirals Ltd, Old Denshott, Leigh, Reigate, Surrey, UK article info abstract Article history: The 26th International Conference on Antiviral Research (ICAR) was held in San Francisco, California from Received 2 August 2013 May 11 to 15, 2013. This article summarizes the principal invited lectures at the meeting. The opening Accepted 8 August 2013 symposium on the legacy of the late Antonín Holy´ included presentations on his pioneering work with Available online 21 August 2013 nucleotide analogs, which led to the development of several antiviral drugs including tenofovir. This drug has transformed the treatment of HIV infection and has recently become the first-line therapy for chronic Keywords: hepatitis B. The Gertrude Elion Award lecturer described the anti-HIV activities of the CCR5 inhibitor Human immunodeficiency virus cenicriviroc and the reverse transcriptase inhibitor festinavirÒ, and also reviewed the evaluation of bio- Hepatitis B degradable nanoparticles with adjuvant activity. The William Prusoff Award winner reported on the cre- Hepatitis C Herpesviruses ation of NAOMI, a computer model with 21 enzymes to predict the activity of nucleoside analogs against Antiviral therapy hepatitis C virus (HCV). Other invited lecturers discussed the development of countermeasures against severe dengue and the potential of RNA virus capping and repair enzymes as drug targets. Topics in the clinical symposium included the current status of the anti-HCV compounds sovaprevir, ACH-3102, miravirsen and ALS-2200; the evaluation of single-tablet regimens for HIV infection; and the investiga- tion of cytomegalovirus resistance to CMX001. -
Johnson & Johnson to Acquire Tibotec-Virco
Johnson & Johnson to Acquire Tibotec-Virco NEW BRUNSWICK, N.J., March 22 /PRNewswire-FirstCall/ -- Johnson & Johnson today announced it has signed a definitive agreement to acquire all of the assets of Tibotec-Virco NV, a privately-held biopharmaceutical company focused on developing anti-viral treatments, with several promising compounds in development for the treatment of infectious diseases including HIV. The transaction is valued at approximately $320 million in cash and debt. Johnson & Johnson is expected to incur a one-time charge of approximately $145 million, or $0.05 per share, upon closing, reflecting the write-off of in-process research and development costs. The transaction is anticipated to close in the second quarter of 2002 subject to customary closing conditions and regulatory approvals. Excluding one-time charges, the acquisition is not expected to impact earnings for 2002 or 2003. "Tibotec-Virco will provide a good strategic fit with our current pharmaceutical research and development operations," said Dr. Per Peterson, Chairman, Research & Development for the pharmaceuticals group of Johnson & Johnson. "By combining Tibotec-Virco's expertise with our own research and development activities, we will expand our drug discovery and development capabilities, particularly in the field of anti-viral therapies." Headquartered in Mechelen, Belgium, Tibotec-Virco applies the latest techniques in ultra-high throughput screening, pharmacogenomics, molecular biology and artificial intelligence to discovering and developing new drugs. The company has drug discovery and development programs focusing on potential new drugs that are active against drug-resistant strains of HIV including two products in early clinical development. Tibotec-Virco also has early stage research programs concentrating on the development of treatments for hepatitis C and other infectious diseases. -
Life Sciences 2010.Key
LIFE SCIENCES FLANDERS Prof. Dr. Ann Van Gysel, Managing Director FlandersBio FLANDERS, BELGIUM Centrally Located Biotech hub SUCCESSFUL BIOTECH HUB • World renowned research centers, universities and hospitals • 143 life sciences companies with biotech activities • 118 conduct innovative R&D • Flanders ranks no 2 in Europe • Total market cap, stock listed biotech companies • Flanders Ranks no 1in Europe • Annual life sciences convention >900 participants LIFE SCIENCES AREAS • Medical Biotech - focus on healthcare, from diagnostics to therapeutics • Plant Biotech - largest R&D hub in Europe, from molecular breeding to GMOs • Industrial Biotech - focus on bioprocessing, from enzymes to biofuels and food STRONG IN R&D • Innovative research • Strong life sciences companies network • Big in Biopharma • Clinical excellence INNOVATIVE RESEARCH • High quality universities • Excellent research institutes, focus on life sciences • VIB [world class biotech research] • IMEC [focus on nanotechnology] • CMI [translational medicine] Ind. Products Health care Agro & Food R&D provider Tech provider 143 BIOTECH COMPANIES 12 24 21 15 64 Ind. Products Health care Agro & Food R&D provider 13.000 Tech provider EMPLOYEES IN 384 R&D 1.163212 >30.000 in total 4.648 6.652 BELGIUM, HOME TO ... • Pharmaceutical companies • 5% of the top-100 drugs are developed in Belgium • Per capita the highest number of drugs in development • Total production: 5.2 billion euro • Total export value: 34 billion euro source: pharma.be CLINICAL EXCELLENCE • Dense medical network • -
Resistance Analyses in HIV Infected Patients with a History of Multiple
Sex Transm Inf 2001;77:449–452 449 Sex Transm Infect: first published as 10.1136/sti.77.6.449 on 1 December 2001. Downloaded from Resistance analyses in HIV infected patients with Original a history of multiple antiretroviral treatment article regimens Andreas Plettenberg, Dirk Albrecht, Thore Lorenzen, Volker Paech, Heiko Petersen, Thomas Fenner, Thomas Meyer, Rüdiger Arndt, Kurt Hertogs, Rudi Pauwels, Thomas Weitzel, Albrecht Stoehr Objective: To assess HIV-1 isolate based resistance profiles from extensively pretreated patients and eVects of a resistance guided switch of antiretroviral therapy. Methods: In a prospective study phenotypic and genotypic resistance analyses were performed on HIV infected individuals with failure of the current therapy and history of at least three anti- retroviral regimens. Antiretroviral therapy was changed according to the results. Viral load and CD4 lymphocyte counts were measured at baseline, after 10 (SD 2), and 24 (2) weeks. Results: All patients (n=52) failed their actual regimen. Currently versus ever previously taking the specific drug, resistance associated mutations and phenotypic resistance to AZT and 3TC were found in over 80% of individuals; resistance to DDI and D4T was detected in less than 10% of cases. A resistance guided switch of therapy was followed by a median decrease of viral load of 0.5 log10 units after 24 weeks. Individuals resistant to two or more drugs compared with patients with resistance to less than two drugs of ongoing treatment, were switched to a regimen contain- ing DDI, D4T, and a PI or NNRTI. After 10 (SD 2) weeks viral load decrease was pronounced in patients with resistance to at least two drugs in the previous regimen. -
Book Review Paul Janssen
BOOK REVIEW PAUL JANSSEN: PIONEER IN PHARMA & IN CHINA By Geerdt Magiels, Dundee: Dundee University Press, 2008, 258 pp. (incl. appendices and bibliography), £15.00, ISBN 978-1-84586-53-0 The history of Janssen Pharmaceutica and its evolvement in China is central to this homage to Paul Janssen, who set up the company in 1953; led it through a merger with Johnson & Johnson in 1961; built up relations with China from the 1960s onwards; and left clear footprints on its research agenda and company management style. The book owes its existence to Paul Janssen, who commissioned it to the author Geerdt Magiels. However, Janssen died shortly after their first meeting in 2003. The book aims to make known the scientific, business and human achievements of Paul Janssen. As such, there are scatterings of descriptions of major events in Janssen’s life; group photographs of important occasions and celebrations; and advice and adages on how to collaborate (for example, to have an open mind; to be creative; to allow local people to run the business; to work through friendship and compromise; to have patience; and to show mutual respect). The book gives corporate meaning to a global audience of the role of large pharmaceutical companies in developing countries. A role that involves the efforts made by such companies to advertise themselves as a bridge between rich and poor; their motivation by concerns for global health; and contributors to the well-being and development of people in developing countries. As a eulogy, this book can hardly be expected to meet academic standards. -
Janssen Diagnostics and Biocartis Announce Launch of Influenza-Respiratory Virus Panel on the Idylla™ Platform
PRESS RELEASE Janssen Diagnostics and Biocartis announce launch of Influenza-Respiratory Virus Panel on the Idylla™ platform Mechelen and Beerse, Belgium, 30 November 2015 - Janssen Diagnostics, part of the Johnson & Johnson family of companies (NYSE: JNJ) and Biocartis (Euronext Brussels: BCART), an innovative molecular diagnostics company, today announced the launch of their first infectious disease test on the Idylla™ platform. The Idylla™ Respiratory IFV-RSV Panel has been developed by Janssen Diagnostics and is intended for the detection of various strains of Influenza Virus (IFV) and Respiratory Syncytial Virus (RSV). The Idylla™ Respiratory IFV-RSV Panel received CE-IVD marking on 18 November 2015 and is being launched for commercial use in Europe and other geographies recognising the CE-mark. Janssen Diagnostics has appointed Biocartis as co-exclusive worldwide distributor of the test. Respiratory viruses are one of the most important causes of morbidity and mortality throughout the world1 with the influenza virus killing at least 50 million and up to 100 million people in the last century alone2. The majority of diagnostic tests currently used for this market are rapid immunoassays which are chosen due to their low cost and convenience. However, one of the key downsides of these rapid tests is their poor sensitivity. Negative samples are typically re-tested in a central lab with a more sensitive molecular test, delaying time-to-result by many hours. The new Idylla™ Respiratory IFV-RSV Panel, running on the Idylla™ platform, combines in one single product the speed of rapid tests with the quality and sensitivity standards of central lab tests.