DOCSLIB.ORG

Physiologistphysiologist

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Physiologistphysiologist Integrating the Life Sciences from Molecule to Organism TheThe PhysiologistPhysiologist A Publication of the American Physiological Society Volume 54, No. 6 December 2011 2011 American Physiological Society Meetings Program and Abstracts Issue 20112 APS Conference: 7tht International Symposium on Aldosterone andan the ENaC/Degenerin Family of Ion Channels: MMolecular Mechanisms and Pathophysiology (September(S 2011, Pacific Grove, California) 2011 APS Conference: Physiology of Cardiovascular Disease: Gender Disparities (October 2011, Jackson, Mississippi) Fast track your research and publishing Accelerate the pace of your research with the data acquisition systems cited in more published papers*. ADInstruments PowerLab® systems are easy to use, intuitive and powerful, allowing you to start and progress research quickly. The system’s fl exibility enables you to add specialist instruments and software- controlled amplifi ers for your specifi c experiments. What’s more, LabChart® software (included with every system), offers parameters tailored to individual applications and unmatched data integrity for indisputably trustworthy data. When there’s no prize for second place, ADInstruments PowerLab systems help you to publish. First. To fi nd out more, visit adinstruments.com/publish *According to Google Scholar, ADInstruments systems are cited in over 50,000 published papers and other works of scholarly literature. USA • BRAZIL • CHILE • UK • GERMANY • INDIA • JAPAN • CHINA • MALAYSIA • NEW ZEALAND • AUSTRALIA SADI0004_APS_PowerLab_printsoni page 1.indd 1 31/03/11 3:03 PM Published by The American Physiological Society Integrating the Life Sciences from Molecule to Organism The PhysiologistPhysiologist Physiology: Evolving, Not Declining Dee U. Silverthorn Integrative Biology, Univ. of Texas INSIDE In April 2011 The Scientist maga- Physiology” is a theme that has been zine published an opinion piece by repeated many times and has been Richard Naftalin, a British physiolo- written about at regular intervals over gist, titled “The Decline of Physiology” the last 40 years (5, 8, 10, 11, 16, 28). APS Bylaw (20). Despite the foreboding title and The reality is that as research tools for accompanying photograph of a dissect- investigating physiological mecha- Changes ed grass frog, the article dealt largely nisms shifted from whole animal and p. 237 with the decline in physiology teaching tissue studies to cellular and molecu- in British medical schools: fewer lec- lar levels of organization, attention ture hours, the loss of animal-based moved away from the traditional sci- Experimental laboratory classes, and replacement of entific disciplines, and a chasm devel- Biology 2012 practical laboratories with demonstra- oped between researchers and physiol- p. 246 tions, computer-aided learning pro- ogy educators. Departments of physiol- grams and problem-based learning ogy disappeared, subsumed into (PBL) sessions that focused on human departments of basic biomedical sci- APS Promotes medicine to the exclusion of funda- ences for budgetary reasons or Physiology to mental basic science. An expanded ver- renamed, with titles such as Biology Educators sion of the article (actually the original “Molecular Physiology and Biophysics” essay, which was too long for The or “Cellular and Molecular at National Scientist) was subsequently published Physiology,” to be more attractive to Convention in Physiology News, The Physiological contemporary researchers. Even more p. 250 Society newsletter, under the title “The alarming in terms of the pipeline for decline of physiology teaching in physiologists of the future, physiology British universities” (19; R. Naftalin, began to disappear from the under- APS Conference personal communication). The two graduate biology curriculum. Reports articles were then followed by a debate Is Physiology a discipline that needs p. 253 at the July 2011 meeting of The to be preserved? In answer to the Physiological Society on the state- debate statement, “Physiology as a ment, “Physiology as a separate disci- separate discipline is no longer rele- Science Policy pline is no longer relevant to modern vant to modern science,” I would con- Members Advocate science” (24). Naftalin’s article in The tend that physiology will never be Scientist struck a chord with physiolo- irrelevant as long as there is life on for Research gists around the world, and evoked a earth. Physiology is arguably the most Funding lively discussion on the International egalitarian of the biological disci- p. 260 Union of Physiological Societies plines. It is integrative, spanning all (IUPS) Teaching listserve and a ses- levels of organization, from biochem- sion on “decline” at the September istry and cell biology to the physiolog- Brinster and Chien 2011 Federations of Asian and ical adaptations that allow species to Receive National Oceanian Physiological Societies occupy particular ecological niches. Medal of Science (FAOPS) meeting in Taiwan. Physiology embraces physics and But is Physiology really declining? mathematics and engineering and p. 262 Concern about “the future of (continued on page 238) Volume 54, No. 6 - December 2011 www.the-aps.org 233 Published bimonthly and distributed by The American Physiological TheThe Society PhysiologistPhysiologist 9650 Rockville Pike Bethesda, Maryland 20814-3991 ISSN 0031-9376 Joey P. Granger President Contents Peter D. Wagner Past President Susan M. Barman Physiology: Evolving, Not Declining Membership President-Elect Dee U. Silverthorn 233 New Regular Members 257 Martin Frank Editor and Executive Director New Undergraduate Student Institute for Integrative Members 257 Councillors Kenneth M. Baldwin, Physiology: Resurrection of New Graduate Student Members 257 David P. Brooks, Physiology at the Recently Deceased Member 257 Dennis Brown, Patricia E. Molina, Ida Llewellyn-Smith, Univ. of Chicago Usha Raj, Jane F. Reckelhoff, Nanduri R. Prabhakar 235 Science Policy Curt D. Sigmund, Alan F. Sved APS Comments on the Future Ex Officio APS News of the Biomedical Workforce 259 Pamela K. Carmines, John C. Chatham, APS Bylaw Changes 237 Science Policy Committee Thomas A. Pressley, Members Advocate for Research Hershel Raff, Jeff M. Sands Chapter News Funding 260 Tennessee Physiological Society Publications Committee: Chair: Hershel Raff; Members: Kim E. Meeting 2011 243 Mentoring Forum Barrett, William Chilian, Asrar Summer Research Programs 261 Malik, David Pollock, Helen E. Raybould, Celia Sladek. Director of Experimental Biology 2012 246 Publications: Rita Scheman. People & Places Design and Copy Editor: Joelle R. Grossnickle. Education Brinster and Chien Receive Subscriptions: Distributed to Two APS Members Awarded the 2011 National Medal of Science 262 members as part of their member- ASBMB STEM SEED Grant for Nishimura Receives Lifetime ship. Nonmembers in the USA (print only): individuals $85.00; PhUn Week Activities 248 Achievement Award 263 institutions $135.00. Nonmembers APS Leads Teachers to New APS Congratulates Garcia and in Canada: individuals $125.00; institutions $170.00. Nonmembers Physiology Frontiers in Online Hökfelt on Their IOM Election 263 elsewhere: individuals $125.00; Program 249 institutions $170.00. Single copies and back issues when available, APS Promotes Physiology to Book Review 264 $20.00 each; single copies and back Biology Educators at National issues of Abstracts issues when available, $30.00. Subscribers to Convention 250 Positions Available 265 The Physiologist also receive APS Archive of Teaching Resources abstracts of the Conferences of the American Physiological Society. Thanks its 2011 Reviewers 250 Current Calls for Papers 268 The online version is available free APS Undergraduate Summer to all worldwide. Research Fellows Wine Wizard 269 The American Physiological Society assumes no responsibility for the Finish Research 251 statements and opinions advanced Meetings & Congresses 270 by contributors to The Physiologist. APS Conferences Please notify the APS Member- ship Department as soon as 7th International Symposium on APS Membership Application 271 possible if you change your Aldosterone and the address or telephone number. ENaC/Degenerin Family of Ion APS Conference Programs 273 Headquarters phone: 301-634-7118 Fax: 301-634-7241 Channels: Molecular Mechanisms Email: [email protected] and Pathophysiology 253 http://www.the-aps.org Physiology of Cardiovascular Printed in the USA Disease: Gender Disparities 255 234 The Physiologist Resurrection of Physiology Vol. 54, No. 6, 2011 Institute for Integrative Physiology: Resurrection of Physiology at the University of Chicago Nanduri R. Prabhakar Institute for Integrative Physiology University of Chicago The University of Chicago is one of Anton Julius Carlson (“Ajax”) who a uniform potential. He used this tech- the oldest US universities founded in joined the faculty in 1904 after receiv- nique to clamp the current of neurons. 1890 by the American Baptist ing his doctorate (in physiology) from Using the idea of the space clamp, Education Society and oil magnate Stanford. Carlson was the Chair of the Kenneth S. Cole introduced the voltage John D. Rockefeller. The first president department from 1916 to 1940. Carlson clamp to the world, which was used William Rainey Harper, hoped for a had an impact on a variety of different soon afterwards by Hodgkin and university that combined an American- areas of physiology. He was undoubted- Huxley in their pioneering work. Both style undergraduate liberal arts college ly one of the preeminent
Load more

Recommended publications
  • Androgen Excess in Breast Cancer Development: Implications for Prevention and Treatment
    26 2 Endocrine-Related G Secreto et al. Androgen excess in breast 26:2 R81–R94 Cancer cancer development REVIEW Androgen excess in breast cancer development: implications for prevention and treatment Giorgio Secreto1, Alessandro Girombelli2 and Vittorio Krogh1 1Epidemiology and Prevention Unit, Fondazione IRCCS – Istituto Nazionale dei Tumori, Milano, Italy 2Anesthesia and Critical Care Medicine, ASST – Grande Ospedale Metropolitano Niguarda, Milano, Italy Correspondence should be addressed to G Secreto: [email protected] Abstract The aim of this review is to highlight the pivotal role of androgen excess in the Key Words development of breast cancer. Available evidence suggests that testosterone f breast cancer controls breast epithelial growth through a balanced interaction between its two f ER-positive active metabolites: cell proliferation is promoted by estradiol while it is inhibited by f ER-negative dihydrotestosterone. A chronic overproduction of testosterone (e.g. ovarian stromal f androgen/estrogen balance hyperplasia) results in an increased estrogen production and cell proliferation that f androgen excess are no longer counterbalanced by dihydrotestosterone. This shift in the androgen/ f testosterone estrogen balance partakes in the genesis of ER-positive tumors. The mammary gland f estradiol is a modified apocrine gland, a fact rarely considered in breast carcinogenesis. When f dihydrotestosterone stimulated by androgens, apocrine cells synthesize epidermal growth factor (EGF) that triggers the ErbB family receptors. These include the EGF receptor and the human epithelial growth factor 2, both well known for stimulating cellular proliferation. As a result, an excessive production of androgens is capable of directly stimulating growth in apocrine and apocrine-like tumors, a subset of ER-negative/AR-positive tumors.
    [Show full text]
  • The Creation of Neuroscience
    The Creation of Neuroscience The Society for Neuroscience and the Quest for Disciplinary Unity 1969-1995 Introduction rom the molecular biology of a single neuron to the breathtakingly complex circuitry of the entire human nervous system, our understanding of the brain and how it works has undergone radical F changes over the past century. These advances have brought us tantalizingly closer to genu- inely mechanistic and scientifically rigorous explanations of how the brain’s roughly 100 billion neurons, interacting through trillions of synaptic connections, function both as single units and as larger ensem- bles. The professional field of neuroscience, in keeping pace with these important scientific develop- ments, has dramatically reshaped the organization of biological sciences across the globe over the last 50 years. Much like physics during its dominant era in the 1950s and 1960s, neuroscience has become the leading scientific discipline with regard to funding, numbers of scientists, and numbers of trainees. Furthermore, neuroscience as fact, explanation, and myth has just as dramatically redrawn our cultural landscape and redefined how Western popular culture understands who we are as individuals. In the 1950s, especially in the United States, Freud and his successors stood at the center of all cultural expla- nations for psychological suffering. In the new millennium, we perceive such suffering as erupting no longer from a repressed unconscious but, instead, from a pathophysiology rooted in and caused by brain abnormalities and dysfunctions. Indeed, the normal as well as the pathological have become thoroughly neurobiological in the last several decades. In the process, entirely new vistas have opened up in fields ranging from neuroeconomics and neurophilosophy to consumer products, as exemplified by an entire line of soft drinks advertised as offering “neuro” benefits.
    [Show full text]
  • Richard Llewelyn-Davies and the Architect's Dilemma."
    The Richard Llewciy11-Davies Memorial Lectures in ENVIRONMENT AND SOCIETY March 3, 1985-at the Institute for Advanced Study The J/ictoria11 City: Images and Realities Asa Briggs Provost of Worcester College University of Oxford November 17, 1986--at the University of London The Nuffield Planning Inquiry Brian Flo\vers Vice-Chancellor University of London October 27, 1987-at the Institute for Advanced Study Richard Llewcly11-Davics and the Architect's Dilemma N ocl Annan Vice-Chancellor Erncritus University of London PREFACE The Richard Llewelyn-Davies Memorial Lectures in "Environ­ ment and Society" were established to honor the memory of an architect distinguished in the fields of contemporary architectural, urban and environmental planning. Born in Wales in 1912, Richard Llewelyn-Davies was educated at Trinity College, Cambridge, !'Ecole des Beaux Arts in Paris and the Architectural Association in London. In 1960 he began a fif­ teen-year association with University College of the University of London as Professor of Architecture, Professor of Town Planning, Head of the Bartlett School of Architecture and Dean of the School of Environmental Studies. He became, in 1967, the initial chair­ man of Britain's Centre for Environmental Studies, one of the world's leading research organizations on urbanism, and held that post for the rest of his life. He combined his academic career with professional practice in England, the Middle East, Africa, Paki­ stan, North and South America. In the fall of 1980, the year before he died, Richard Llewelyn­ Davies came to the Institute for Advanced Study. He influenced us in many ways, from a reorientation of the seating arrangement in the seminar room improving discussion and exchange, to the per­ manent implantation of an environmental sensibility.
    [Show full text]
  • Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
    Cambridge's 92 Nobel Prize winners part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin By Cambridge News | Posted: January 18, 2016 By Adam Care The News has been rounding up all of Cambridge's 92 Nobel Laureates, celebrating over 100 years of scientific and social innovation. ADVERTISING In this installment we move from 1951 to 1974, a period which saw a host of dramatic breakthroughs, in biology, atomic science, the discovery of pulsars and theories of global trade. It's also a period which saw The Eagle pub come to national prominence and the appearance of the first female name in Cambridge University's long Nobel history. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1. 1951 Ernest Walton, Trinity College: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei 2. 1951 John Cockcroft, St John's / Churchill Colleges: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei Walton and Cockcroft shared the 1951 physics prize after they famously 'split the atom' in Cambridge 1932, ushering in the nuclear age with their particle accelerator, the Cockcroft-Walton generator. In later years Walton returned to his native Ireland, as a fellow of Trinity College Dublin, while in 1951 Cockcroft became the first master of Churchill College, where he died 16 years later. 3. 1952 Archer Martin, Peterhouse: Nobel Prize in Chemistry, for developing partition chromatography 4.
    [Show full text]
  • Estrogen Deficiency During Menopause and Its Management: a Current Update V
    Review Article Estrogen deficiency during menopause and its management: A current update V. T. Hemalatha1, A. Julius2, S. P. Kishore Kumar3, L. Vijayalakshmi4, Shankar Narayanan1 ABSTRACT Different phases of a woman’s life: Puberty, menses, pregnancy, and menopause have varied influence on her oral health. During the menopause, women go through biological and endocrine changes, particularly in their sex steroid hormone production, affecting their health. Sex hormones strongly influence body fat distribution and adipocyte differentiation. Estrogens and testosterone differentially affect adipocyte physiology, but the importance of estrogens in the development of metabolic diseases during menopause is disputed. Estrogens and estrogens receptor regulate various aspects of glucose and lipid metabolism. Disturbances of this metabolic signal lead to the development of metabolic syndrome and a higher cardiovascular risk in woman. The absence of estrogens is a clue factor in the onset of cardiovascular disease during the menopausal period, which is characterized by lipid profile variations and predominant abdominal fat accumulation. However, influence of the absence of these hormones and its relationship to higher obesity in women during menopause is not clear. This systematic review discusses of the role of estrogens and estrogen receptors in adipocyte differentiation and its various effects and brief discussion on its management. KEY WORDS: Estrogen hormone (estrogens/progestogens) replacement therapy, Menopause, Weight gain INTRODUCTION BODY CHANGES AT MENOPAUSE Menopause occurs when a woman stops ovulating and As we age, our muscles decrease in bulk and our her monthly period (menstruation) stops. metabolism slows down. These changes cancontribute to weight gain around the time of menopause. Other As women age, into their 40s and 50s, there is a tendency physical changes associated with menopause may to gain weight.
    [Show full text]
  • The Birth of Information in the Brain: Edgar Adrian and the Vacuum Tube,” Science in Context 28: 31-52
    Garson, J. (2015) “The Birth of Information in the Brain: Edgar Adrian and the Vacuum Tube,” Science in Context 28: 31-52. Preprint (not copyedited or formatted) Please use DOI when citing or quoting: https://doi- org.proxy.wexler.hunter.cuny.edu/10.1017/S0269889714000313 The Birth of Information in the Brain: Edgar Adrian and the Vacuum Tube Word Count: 10, 418 Abstract: As historian Henning Schmidgen notes, the scientific study of the nervous system would have been ‘unthinkable’ without the industrialization of communication in the 1830s. Historians have investigated extensively the way nerve physiologists have borrowed concepts and tools from the field of communications, particularly regarding the nineteenth-century work of figures like Helmholtz and in the American Cold War Era. The following focuses specifically on the interwar research of the Cambridge physiologist Edgar Douglas Adrian, and on the technology that led to his Nobel-Prize- winning research, the thermionic vacuum tube. Many countries used the vacuum tube during the war for the purpose of amplifying and intercepting coded messages. These events provided a context for Adrian’s evolving understanding of the nerve fiber in the 1920s. In particular, they provide the background for Adrian’s transition around 1926 to describing the nerve impulse in terms of “information,” “messages,” “signals,” or even “codes,” and for translating the basic principles of the nerve, such as the all-or-none principle and adaptation, into such an “informational” context. The following also places Adrian’s research in the broader context of the changing relationship between science and technology, and between physics and physiology, in the first few decades of the twentieth century.
    [Show full text]
  • The Importance of a Higher Dose of a Mineralocorticoid Receptor Antagonist in Reducing
    CRVASA-544; No. of Pages 4 c o r e t v a s a x x x ( 2 0 1 7 ) e 1 – e 4 Available online at www.sciencedirect.com ScienceDirect journal homepage: http://www.elsevier.com/locate/crvasa Case report The importance of a higher dose of a mineralocorticoid receptor antagonist in reducing risk of recurrent hospitalization in a patient with advanced chronic heart failure – A case report a, a b G. Mairgani *, V. Mála , F. Málek a Odděleni Interna I, Nemocnice Teplice, Krajská zdravotní, a.s., Czech Republic b Kardiocentrum, Nemocnice Na Homolce, Praha, Czech Republic a r t i c l e i n f o a b s t r a c t Article history: The authors present the significance of a higher dose of a mineralocorticoid receptor Received 10 March 2017 antagonist in reducing the frequency of hospitalizations for decompensated heart failure Received in revised form in a 67-year-old patient suffering from advanced chronic heart failure. 9 August 2017 © 2017 The Czech Society of Cardiology. Published by Elsevier Sp. z o.o. All rights reserved. Accepted 19 August 2017 Available online xxx Keywords: Advanced chronic heart failure Mineral corticoid receptor antagonists Eplerenone nervous system and the renin–angiotensin–aldosterone sys- tem (RAAS). The short-term effects include increased heart Introduction activity, vasoconstriction and fluid retention, and the long- term effects are myocyte hypertrophy, apoptosis and myocard Heart failure is defined as a state when the heart is unable to fibrosis (left ventricular remodeling). There is also an increase pump blood with normal venous return according to the needs in the production of vasodilatation mediators (prostaglandins, of tissue metabolism or a state when it is only be able to do so natriuretic peptides, bradykinin and others); however, these with an increased ventricular filling pressure.
    [Show full text]
  • TRINITY COLLEGE Cambridge Trinity College Cambridge College Trinity Annual Record Annual
    2016 TRINITY COLLEGE cambridge trinity college cambridge annual record annual record 2016 Trinity College Cambridge Annual Record 2015–2016 Trinity College Cambridge CB2 1TQ Telephone: 01223 338400 e-mail: [email protected] website: www.trin.cam.ac.uk Contents 5 Editorial 11 Commemoration 12 Chapel Address 15 The Health of the College 18 The Master’s Response on Behalf of the College 25 Alumni Relations & Development 26 Alumni Relations and Associations 37 Dining Privileges 38 Annual Gatherings 39 Alumni Achievements CONTENTS 44 Donations to the College Library 47 College Activities 48 First & Third Trinity Boat Club 53 Field Clubs 71 Students’ Union and Societies 80 College Choir 83 Features 84 Hermes 86 Inside a Pirate’s Cookbook 93 “… Through a Glass Darkly…” 102 Robert Smith, John Harrison, and a College Clock 109 ‘We need to talk about Erskine’ 117 My time as advisor to the BBC’s War and Peace TRINITY ANNUAL RECORD 2016 | 3 123 Fellows, Staff, and Students 124 The Master and Fellows 139 Appointments and Distinctions 141 In Memoriam 155 A Ninetieth Birthday Speech 158 An Eightieth Birthday Speech 167 College Notes 181 The Register 182 In Memoriam 186 Addresses wanted CONTENTS TRINITY ANNUAL RECORD 2016 | 4 Editorial It is with some trepidation that I step into Boyd Hilton’s shoes and take on the editorship of this journal. He managed the transition to ‘glossy’ with flair and panache. As historian of the College and sometime holder of many of its working offices, he also brought a knowledge of its past and an understanding of its mysteries that I am unable to match.
    [Show full text]
  • Ovid MEDLINE(R)
    Supplementary material BMJ Open Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily <1946 to September 16, 2019> # Searches Results 1 exp Hypertension/ 247434 2 hypertens*.tw,kf. 420857 3 ((high* or elevat* or greater* or control*) adj4 (blood or systolic or diastolic) adj4 68657 pressure*).tw,kf. 4 1 or 2 or 3 501365 5 Sex Characteristics/ 52287 6 Sex/ 7632 7 Sex ratio/ 9049 8 Sex Factors/ 254781 9 ((sex* or gender* or man or men or male* or woman or women or female*) adj3 336361 (difference* or different or characteristic* or ratio* or factor* or imbalanc* or issue* or specific* or disparit* or dependen* or dimorphism* or gap or gaps or influenc* or discrepan* or distribut* or composition*)).tw,kf. 10 or/5-9 559186 11 4 and 10 24653 12 exp Antihypertensive Agents/ 254343 13 (antihypertensiv* or anti-hypertensiv* or ((anti?hyperten* or anti-hyperten*) adj5 52111 (therap* or treat* or effective*))).tw,kf. 14 Calcium Channel Blockers/ 36287 15 (calcium adj2 (channel* or exogenous*) adj2 (block* or inhibitor* or 20534 antagonist*)).tw,kf. 16 (agatoxin or amlodipine or anipamil or aranidipine or atagabalin or azelnidipine or 86627 azidodiltiazem or azidopamil or azidopine or belfosdil or benidipine or bepridil or brinazarone or calciseptine or caroverine or cilnidipine or clentiazem or clevidipine or columbianadin or conotoxin or cronidipine or darodipine or deacetyl n nordiltiazem or deacetyl n o dinordiltiazem or deacetyl o nordiltiazem or deacetyldiltiazem or dealkylnorverapamil or dealkylverapamil
    [Show full text]
  • The Fessard's School of Neurophysiology After
    The fessard’s School of neurophysiology after the Second World War in france: globalisation and diversity in neurophysiological research (1938-1955) Jean-Gaël Barbara To cite this version: Jean-Gaël Barbara. The fessard’s School of neurophysiology after the Second World War in france: globalisation and diversity in neurophysiological research (1938-1955). Archives Italiennes de Biologie, Universita degli Studi di Pisa, 2011. halshs-03090650 HAL Id: halshs-03090650 https://halshs.archives-ouvertes.fr/halshs-03090650 Submitted on 11 Jan 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. The Fessard’s School of neurophysiology after the Second World War in France: globalization and diversity in neurophysiological research (1938-1955) Jean- Gaël Barbara Université Pierre et Marie Curie, Paris, Centre National de la Recherche Scientifique, CNRS UMR 7102 Université Denis Diderot, Paris, Centre National de la Recherche Scientifique, CNRS UMR 7219 [email protected] Postal Address : JG Barbara, UPMC, case 14, 7 quai Saint Bernard, 75005,
    [Show full text]
  • Management of Women with Premature Ovarian Insufficiency
    Management of women with premature ovarian insufficiency Guideline of the European Society of Human Reproduction and Embryology POI Guideline Development Group December 2015 1 Disclaimer The European Society of Human Reproduction and Embryology (hereinafter referred to as 'ESHRE') developed the current clinical practice guideline, to provide clinical recommendations to improve the quality of healthcare delivery within the European field of human reproduction and embryology. This guideline represents the views of ESHRE, which were achieved after careful consideration of the scientific evidence available at the time of preparation. In the absence of scientific evidence on certain aspects, a consensus between the relevant ESHRE stakeholders has been obtained. The aim of clinical practice guidelines is to aid healthcare professionals in everyday clinical decisions about appropriate and effective care of their patients. However, adherence to these clinical practice guidelines does not guarantee a successful or specific outcome, nor does it establish a standard of care. Clinical practice guidelines do not override the healthcare professional's clinical judgment in diagnosis and treatment of particular patients. Ultimately, healthcare professionals must make their own clinical decisions on a case-by-case basis, using their clinical judgment, knowledge, and expertise, and taking into account the condition, circumstances, and wishes of the individual patient, in consultation with that patient and/or the guardian or carer. ESHRE makes no warranty, express or implied, regarding the clinical practice guidelines and specifically excludes any warranties of merchantability and fitness for a particular use or purpose. ESHRE shall not be liable for direct, indirect, special, incidental, or consequential damages related to the use of the information contained herein.
    [Show full text]
  • A Pharmaceutical Product for Hormone Replacement Therapy Comprising Tibolone Or a Derivative Thereof and Estradiol Or a Derivative Thereof
    Europäisches Patentamt *EP001522306A1* (19) European Patent Office Office européen des brevets (11) EP 1 522 306 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.7: A61K 31/567, A61K 31/565, 13.04.2005 Bulletin 2005/15 A61P 15/12 (21) Application number: 03103726.0 (22) Date of filing: 08.10.2003 (84) Designated Contracting States: • Perez, Francisco AT BE BG CH CY CZ DE DK EE ES FI FR GB GR 08970 Sant Joan Despi (Barcelona) (ES) HU IE IT LI LU MC NL PT RO SE SI SK TR • Banado M., Carlos Designated Extension States: 28033 Madrid (ES) AL LT LV MK (74) Representative: Markvardsen, Peter et al (71) Applicant: Liconsa, Liberacion Controlada de Markvardsen Patents, Sustancias Activas, S.A. Patent Department, 08028 Barcelona (ES) P.O. Box 114, Favrholmvaenget 40 (72) Inventors: 3400 Hilleroed (DK) • Palacios, Santiago 28001 Madrid (ES) (54) A pharmaceutical product for hormone replacement therapy comprising tibolone or a derivative thereof and estradiol or a derivative thereof (57) A pharmaceutical product comprising an effec- arate or sequential use in a method for hormone re- tive amount of tibolone or derivative thereof, an effective placement therapy or prevention of hypoestrogenism amount of estradiol or derivative thereof and a pharma- associated clinical symptoms in a human person, in par- ceutically acceptable carrier, wherein the product is pro- ticular wherein the human is a postmenopausal woman. vided as a combined preparation for simultaneous, sep- EP 1 522 306 A1 Printed by Jouve, 75001 PARIS (FR) 1 EP 1 522 306 A1 2 Description [0008] The review article of Journal of Steroid Bio- chemistry and Molecular Biology (2001), 76(1-5), FIELD OF THE INVENTION: 231-238 provides a review of some of these compara- tive studies.
    [Show full text]