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(G6PD) Deficiencies in a Vivax-Predom Lover et al. Malar J (2018) 17:218 https://doi.org/10.1186/s12936-018-2367-5 Malaria Journal RESEARCH Open Access Prevalence and risk factors for asymptomatic malaria and genotyping of glucose 6‑phosphate (G6PD) defciencies in a vivax‑predominant setting, Lao PDR: implications for sub‑national elimination goals Andrew A. Lover1* , Emily Dantzer1, Bouasy Hongvanthong2, Keobouphaphone Chindavongsa2, Susie Welty3, Tania Reza3, Nimol Khim4, Didier Menard5 and Adam Bennett1 Abstract Background: Lao People Democratic Republic (PDR; Laos), a landlocked country in Southeast Asia, has made impor- tant progress in reducing malaria morbidity and mortality in the past 5–6 years, and the northern provinces have very low reported incidence. To support national progress towards elimination, it is critical to verify and understand these changes in disease burden. Methods: A two-stage cluster cross-sectional survey was conducted in four districts within four northern provinces (Khua, Phongsaly Province; Paktha, Bokeo Province; Nambak, Luang Prabang, and Muang Et, Huaphanh Province). Dur- ing September and October 2016, demographics and malaria risk factors were collected from a total of 1492 house- holds. A total of 5085 persons consented to collection of blood samples for testing, by rapid diagnostic test (RDT) and polymerase chain reaction (PCR)-based testing. Risk factors for infection were examined using logistic regression; and a randomized subset of males was tested for glucose-6-phosphate dehydrogenase (G6PD) defciencies using a combined PCR and sequencing approach. Results: There were zero positives by RDT, and PCR detected Plasmodium infections in 39 (0.77%; 95% CI 0.40–1.47%) of 5082 analysable samples. The species distribution was Plasmodium vivax (28 total); Plasmodium falciparum/P. vivax (5); P. falciparum (3), Plasmodium malariae (2), and P. vivax/P. malariae (1). In multivariable analysis, the main risk factors included having any other cases within the household [aOR 12.83 (95% CI 4.40 to 37.38), p < 0.001]; and lack of bed net ownership within the household [aOR 10.91 (95% 5.42–21.94), p < 0.001]; age, sex and forest-travel were not asso- ciated with parasitaemia. A total of 910 males were tested for the six most common G6PDd in SE Asia; and 30 (3.3%; 95% CI 2.1–5.1%) had a G6PD variant allele associated with G6PD defciency, with the majority being the Union (14) and Viangchan (11) polymorphisms, with smaller numbers of Canton and Mahidol. Conclusion: This is the frst rigorous PCR-based population survey for malaria infection in Northern Lao PDR, and found a very low prevalence of asymptomatic Plasmodium infections by standard PCR methods, with P. vivax predomi- nating in the surveyed districts. Clustering of cases within households, and lack of a bed nets suggest reactive case detection, and scale-up of coverage should be prioritized. The predominance of infections with P. vivax, combined *Correspondence: [email protected]; [email protected] 1 Malaria Elimination Initiative, Institute for Global Health Sciences, University of California, San Francisco, CA, USA Full list of author information is available at the end of the article © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat​iveco​mmons​.org/licen​ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creat​iveco​mmons​.org/ publi​cdoma​in/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Lover et al. Malar J (2018) 17:218 Page 2 of 12 with moderate levels of serious G6PD defciencies highlight the need for careful rollout of primaquine towards elimi- nation goals. Background knowledge gaps in the malaria epidemiology, a large- National programmes in the Greater Mekong subre- scale cross-sectional survey was undertaken to assess gion (GMS) have greatly intensifed malaria control malaria parasitaemia and risk factors for infection. and elimination activities in the past decade [1]. Within Tis survey was the frst of its kind to be undertaken the region (comprising Cambodia, Lao PDR, Myan- in northern Lao PDR, and provides the only PCR-based mar, Tailand, Vietnam and Yunnan province in China) survey with rigorous population sampling in the north morbidity has decreased by 74%, and mortality by 91% provinces of the country. from 2012 to 2016 [2]. After some setbacks from 2011 After decades of reporting a majority of infections to 2015, the Lao People’s Democratic Republic (PDR) is with P. falciparum, the introduction of combination again making rapid progress towards malaria elimina- RDTs, and changing epidemiology, P. vivax is now a tion through increased coverage of interventions and major contribution to malaria burden, comprising intensifcation of programmatic activities, with an 80% 49.2% of all 9300 cases reported nationally in 2017 [3]. reduction in reported cases from 2010 to 2017 (24,000– To help address this parasite reservoir with safe use of 9300) [3]. In part due to this progress, the Lao Minis- primaquine, a secondary objective of this study was to try of Health has made a commitment to eliminate estimate the prevalence of glucose-6-phosphate dehy- both Plasmodium falciparum and Plasmodium vivax in drogenase (G6PD) polymorphisms towards elimination northern areas by 2025, followed by elimination of all of P. vivax in these ethnically diverse areas. species nationwide by 2030 [4]. In low transmission settings in Southeast Asia, many malaria infections may remain unidentifed by routine Methods passive surveillance within the health sector; several Study sites factors contribute to this. Tese include the sub-clinical Te target four districts (Fig. 1) were chosen in consul- parasite reservoir, which is known to make up a sizeable tation with district- and provincial-level malaria staf proportion of all infections [5, 6]. Malaria transmission focusing on areas with known malaria hotspots, and to in the GMS is believed to be largely due to occupational capture representative data from diverse epidemiologi- exposures (forestry, forest-fringe farming, mining, and cal settings within northern provinces. Tese provinces a range of semi-legal and illegal activities within for- are characterized by very mountainous terrain, low ested areas) in these populations who may have limited population density (as low as 11 per km 2 in Phongsaly access to health services [7]. Moreover, these high-risk [10]), and diverse climatic zones. Te primary malaria groups have the potential to transport parasites back vectors include the Anopheles dirus and Anopheles into their home communities, thereby perpetuating minimus complexes. Anopheles dirus sensu stricto is transmission within villages [8, 9]. generally the more efcient vector, but member spe- While there have been large declines in reported cies of both complexes may be exophagic and exophilic, malaria burden specifcally in northern provinces limiting the impact of standard vector control meas- within the last several years, these changes have ures which are currently restricted to ITNs and limited occurred in the absence of any major changes in inter- numbers of treated hammock nets [11]. vention strategy or coverage by the national malaria Te rainy season generally spans from July through programme (CMPE; Center for Malariology, Parasi- October, and while historically malaria was highly sea- tology and Entomology). Te impacts of limitations sonal, there is now less seasonality in reported malaria in data reporting, potential stock outs of commodi- incidence. Tis survey was conducted immediately fol- ties, and other changes within the health sector are lowing the rainy season, between 17 September and 20 unknown. It was, therefore, critical to confrm and to October 2016. Te total population within each district contextualize these rapid changes in reported malaria are: Khua, Phongsaly Province (26,164); Paktha, Bokeo burden to inform national programming. Province (19,182); Nambak, Luang Prabang (68,863); Understanding factors underpinning the decreasing and Muang Et, Huaphanh Province (27,001). Tese are malaria burden may provide policy guidance for pro- very remote areas, with a total with 21% of residents gress in the remainder of the country, and to mitigate across the districts residing in villages without road the potential for malaria resurgence. To address these access [10]. Lover et al. Malar J (2018) 17:218 Page 3 of 12 Fig. 1 Overview of study sites, Lao PDR Survey methods net ownership/use, any travel, forest exposures, and To obtain a representative population sample of the occupational patterns), a short clinical assessment selected districts for the primary outcome of all-species including axillary temperature, and basic demographics Plasmodium prevalence by PCR, a stratifed two-stage were collected for each consenting household member cluster-sampling design was utilized. Within each dis- or visitor (including age, sex, education, primary occu- trict, 25 survey clusters consisting of 50 persons each, pation, and recent travel). Study staf made a maximum were chosen for sampling, to provide 1250 participants of three visits to individual households if all household per district, and 5000 overall. Tis sample size was cal-
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