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Neuromodulation Symposium MINNESOTA NEUROMODULATION SYMPOSIUM APRIL 14 - 15, 2016 THE COMMONS HOTEL MINNEAPOLIS, MN neuromodulation.umn.edu Dear Colleagues, Welcome to the 4th Annual Minnesota Neuromodulation Symposium. Neuromodulation is a rapidly-growing field, encompassing a wide spectrum of implantable and non-invasive technology-based approaches for the treatment of neurological and psychiatric disorders. It represents an important research nexus of basic and clinical neu- roscience, and of engineering sciences. It also represents an important industrial sector in the medical device industry with products already benefiting a number of patients. A collaborative effort by all stakeholders will be needed to further expedite the process of translating basic research discoveries into applied and clinical research, industrial research and development, and even manufacturing, which will result in a more immediate impact to healthcare. This symposium is aimed at bringing together basic scientists, engineers, clinicians, industrial practitioners, entrepreneurs, and policy makers to discuss challenges and opportunities in neuromodulation and neurotechnology. Advancing the field of neuromodulation represents challenges to developing engineering methodologies, understanding mechanisms of neuromodulation at cellular and system levels, translating research to treat patients, and closely integrating the regulatory process within the research and clinical environment. We are very pleased to address these challenges through our outstanding line-up of invited speakers that represent thought leaders from academia, industry, and government, whom over the next two days will review significant progress in neuromodulation and neurotechnology, providing a glimpse into the future of this fascinating field. We are also very pleased that the symposium has attracted a record number of scientific contributions from many institutions to be presented in the Poster Session. With close to 100 abstracts representing 37 different institutions, 18 non-profit organizations, 10 corporations and 12 countries, we are expecting a wonderful meeting and we anticipate warm and vivid discussions. I would like to take this opportunity to thank many colleagues for their great contributions and efforts, to invited speakers and panelists for sharing their visions, to poster and oral presenters for presenting original works, to members of the organizing committee for their great efforts throughout the process, to members of the international program committee for promoting the symposium, to judges who volunteered their time and expertise, and to IEM staff for their tireless efforts. We are also very grateful to our co-sponsors whose support are essential for a successful meeting. I hope that you will find the symposium to be stimulating, productive, and enjoyable. Kind regards, Bin He, Ph.D. Symposium Chair Contents General Information 2 Agenda: Day 1 3 Agenda: Day 2 4 Sponsors 5 Speakers 7 Selected Highlight Talks 12 Posters 13 Abstracts 21 Notes 123 Committees 124 GENERAL INFORMATION CONNECTING TO THE FREE WIRELESS NETWORK Network Name: Commons Convention Password (case sensitive): Neuro16 For Technical Assistance: 1-(877) 254-4571 THE COMMONS HOTEL 615 Washington Ave SE, Minneapolis, MN 55414 2 AGENDA: DAY 1 2:00pm - 2:05pm Welcome Remarks Bin He, PhD Symposium Chair 2:05pm - 2:40pm Plenary Lecture: Closing the DBS Loop in Parkinson’s Disease: The Promise and the Pitfalls Peter Brown, MD Professor of Experimental Neurology Director of the Medical Research Council Brain Network Dynamics Unit University of Oxford Moderator: Bin He, PhD (UMN) 2:40pm - 3:15pm Plenary Lecture: Chronic Ambulatory Brain Recording Using Totally Implanted Devices: Next Steps in Development Philip A. Starr, MD, PhD Professor of Neurological Surgery Dolores Cakebread Endowed Chair University of California, San Francisco Moderator: Jerry Vitek, MD, PhD (UMN) 3:15pm - 3:40pm Invited Talk: Changing the Culture of Neuromodulation Research through the NIH SPARC and BRAIN Initiatives Grace Peng, PhD Program Director Division of Discovery Science & Technology (DDST) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH) Moderator: Kip Ludwig, PhD (Mayo Clinic) 3:40pm -4:10pm Break 4:10pm - 4:35pm Invited Talk: A FDA Staff Perspective on the Regulatory Landscape for Neurotechnologies and Medical Device Readiness Carlos Peña, PhD Director Division of Neurological and Physical Medicine Devices Office of Device Evaluation Center for Devices and Radiological Health Food and Drug Administration (FDA) Moderator: Kelvin Lim, MD (UMN) 4:35pm - 5:00pm Highlights in Neuromodulation I This session consists of brief highlight talks of poster presentations. Moderator: Hubert Lim, PhD (UMN) MNS197: Cortical Implantation of a 16-channel Wireless Floating Microelectrode Array (WFMA) Stimulator. Philip Troyk, Illinois Institute of Technology MNS160: Cortical Sensing and Wearable Closed-loop DBS in an Essential Tremor Patient Jeffrey Herron, University of Washington, Seattle MNS146: Closed-loop Deep Brain Stimulation Effects on Parkinsonian Motor Symptoms — Is Beta Enough? Luke Johnson, UMN MNS111: Dopamine Release in the Nonhuman Primate Caudate and Putamen Depends upon Site of Stimulation in the Subthalamic Nucleus Paul Min, Mayo Clinic, Rochester MNS101: Interrogating Neural Circuitry Underlying Neuroeconomic Decision-making in Mouse Models of Addiction: A Functional Approach to Translation. Brian Sweis, UMN 5:00pm - 6:10pm Panel Discussion – Invasive Neuromodulation: Challenges & Trends Moderator: Jerry Vitek, MD, PhD (UMN) Panelists: Peter Brown (University of Oxford) Stephen Carcieri (Boston Scientific) Steve Goetz (Medtronic) DeLea Peichel (St. Jude Medical) Carlos Peña (FDA) Grace Peng (NIH) Philip A. Starr (University of California, San Francisco) 6:10pm - 8:00pm Reception 3 AGENDA: DAY 2 8:00am - 8:30am Networking Breakfast 8:30am - 9:05am Plenary Lecture: Perturbation-based Translatable Physiologic Biomarkers Alvaro Pascual-Leone, MD, PhD Professor of Neurology, Harvard Medical School Director, Berenson-Allen Center for Noninvasive Brain Stimulation at Beth Israel Deaconess Medical Center Moderator: James Carey, PhD, PT, FAPTA (UMN) 9:05am - 9:40am Plenary Lecture: The Importance of Point Process Models to Quantify the Electroencephalogram Jose C. Principe, PhD Distinguished Professor of Electrical and Computer Engineering BellSouth Professor University of Florida Vice President for Technical Activities IEEE Engineering in Medicine and Biology Society Moderator: Phil Troyk, PhD (Illinois Institute of Technology) 9:40am - 10:05am Neuromodulation Research at UMN Bin He, PhD Director, Institute for Engineering in Medicine Director, Center for Neuroengineering Medtronic-Bakken Endowed Chair for Engineering in Medicine Distinguished McKnight University Professor of Biomedical Engineering Moderator: Tim Ebner, MD, PhD (UMN) 10:05am - 10:30am Highlights in Neuromodulation II This session consists of brief highlight talks of poster presentations. Moderator: Tim Ebner, MD, PhD (UMN) MNS124: Implanted Brain Computer Interface for Real-time Cortical Control of Hand Movements in a Human with Quadriplegia Gaurav Sharma, Battelle Memorial Institute MNS141: Safe Direct Current Stimulation for the Treatment of Chronic Peripheral Pain Gene Fridman, Johns Hopkins University MNS192: Controlling Plasticity in Sensory Cortical Regions Using Multisensory Neuromodulation Cory Gloeckner, UMN MNS205: Investigating TMS-evoked Cortical Responses with EEG in Chronic Stroke Whitney Gray, Emory University MNS145: Improving Motor Recovery after Stroke by Combined rTMS and BCI Training Nessa Johnson, UMN 10:30am - 12:30pm Poster Session 12:00pm - 1:00pm Lunch 1:00pm - 1:35pm Plenary Lecture: Neurotechnologies for Peripheral and Visceral Neuromodulation Nitish V. Thakor, PhD Professor of Biomedical Eng, Electrical Eng, Neurology Director, Neuroengineering Training Program Johns Hopkins University Editor in Chief, Medical and Biological Engineering and Computing Moderator: Tim Denison, PhD (Medtronic) 1:35pm - 2:00pm Invited Talk: Brain-Machine Interfaces Beyond Neuroprosthetics: Controlling Neural Circuits, Restoring Function and Changing the Way We Think Karen Moxon, PhD Professor, Associate Dean for Research, School of Biomedical Engineering Science and Health Systems Drexel University Moderator: David Redish, PhD (UMN) 2:00pm - 3:10pm Panel Discussion – Neuromodulation and Neural Interfacing: Present and Future Moderator: Bin He, PhD (UMN) Panelists: Tim Denison (Medtronic) Hubert Lim (UMN) Karen Moxon (Drexel University) Alvaro Pascual-Leone (Harvard Medical School) Jose C. Principe (University of Florida) Nitish V. Thakor (Johns Hopkins University) 3:10pm - 3:30pm Closing Ceremony – Announcement of Poster Awards 4 SPONSORS ORGANIZED AND SPONSORED BY PLATINUM SPONSORS PREMIERE SPONSORS 5 SPONSORS GOLD SPONSORS MAROON SPONSORS TECHNICAL Co-SPONSORS 6 SPEAKERS Peter Brown, MD Professor of Experimental Neurology Director of the Medical Research Council Brain Network Dynamics Unit University of Oxford Peter Brown is Director of the MRC Brain Network Dynamics Unit at the University of Oxford. The Unit’s goal is to understand and exploit the moment-to-moment interactions between nerve cells that are critical for brain functions, with a special focus on developing novel therapies to specifically target the disturbed circuit interactions arising in disease. Peter Brown is also Professor of Experimental Neurology at
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