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Deep Brain Stimulation and Beyond Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2017 The Clinical and Ethical Practice of Neuromodulation – Deep Brain Stimulation and Beyond Edited by: Christen, Markus <javascript:contributorCitation( ’Christen, Markus’ );>; Müller, Sabine <javascript:contributorCitation( ’Müller, Sabine’ );> DOI: https://doi.org/10.3389/978-2-88945-373-3 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://www.zora.uzh.ch/146054 Edited Scientific Work Published Version The following work is licensed under a Creative Commons: Attribution 4.0 International (CC BY 4.0) License. Originally published at: The Clinical and Ethical Practice of Neuromodulation – Deep Brain Stimulation and Beyond. Edited by: Christen, Markus; Müller, Sabine (2017). Lausanne: Frontiers Media SA. DOI: https://doi.org/10.3389/978-2-88945-373-3 THE CLINICAL AND ETHICAL PRACTICE OF NEUROMODULATION – DEEP BRAIN STIMULATION AND BEYOND EDITED BY : Markus Christen and Sabine Müller PUBLISHED IN : Frontiers in Integrative Neuroscience Frontiers Copyright Statement About Frontiers © Copyright 2007-2017 Frontiers Media SA. All rights reserved. Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering All content included on this site, approach to the world of academia, radically improving the way scholarly research such as text, graphics, logos, button icons, images, video/audio clips, is managed. The grand vision of Frontiers is a world where all people have an equal downloads, data compilations and software, is the property of or is opportunity to seek, share and generate knowledge. 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All copyright, and all rights therein, Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: are protected by national and international copyright laws. they are collections of at least ten articles, all centered on a particular subject. With their The above represents a summary unique mix of varied contributions from Original Research to Review Articles, Frontiers only. For the full conditions see the Research Topics unify the most influential researchers, the latest key findings and historical Conditions for Authors and the Conditions for Website Use. advances in a hot research area! Find out more on how to host your own Frontiers ISSN 1664-8714 Research Topic or contribute to one as an author by contacting the Frontiers Editorial ISBN 978-2-88945-373-3 DOI 10.3389/978-2-88945-373-3 Office:[email protected] Frontiers in Integrative Neuroscience 1 December 2017 | DBS and Beyond THE CLINICAL AND ETHICAL PRACTICE OF NEUROMODULATION – DEEP BRAIN STIMULATION AND BEYOND Topic Editors: Markus Christen, University of Zurich, Switzerland Sabine Müller, Charité - Universitätsmedizin Berlin, Germany Neuromodulation - how will it change our brain and mind? Cover image: Chris Harvey/Shutterstock.com Neuromodulation is among the fastest-growing areas of medicine, involving many diverse spe- cialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern Frontiers in Integrative Neuroscience 2 December 2017 | DBS and Beyond in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are work- ing on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic. Citation: Christen, M., Müller, S., eds. (2017). The Clinical and Ethical Practice of Neuromod- ulation – Deep Brain Stimulation and Beyond. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-373-3 Frontiers in Integrative Neuroscience 3 December 2017 | DBS and Beyond Table of Contents 05 Editorial: The Clinical and Ethical Practice of Neuromodulation – Deep Brain Stimulation and Beyond Markus Christen and Sabine Müller 07 Analyzing 7000 Texts on Deep Brain Stimulation: What Do They Tell Us? Christian Ineichen and Markus Christen 25 Mental Side Effects of Deep Brain Stimulation (DBS) for Movement Disorders: The Futility of Denial Donatus Cyron 29 Is There Still Need for Microelectrode Recording Now the Subthalamic Nucleus Can Be Well Visualized with High Field and Ultrahigh MR Imaging? Ersoy Kocabicak, Onur Alptekin, Linda Ackermans, Pieter Kubben, Mark Kuijf, Erkan Kurt, Rianne Esselink and Yasin Temel 32 Rivaling Paradigms in Psychiatric Neurosurgery: Adjustability Versus Quick Fix Versus Minimal-Invasiveness Sabine Müller, Rita Riedmüller and Ansel van Oosterhout 37 Characterizing the Therapeutic Response to Deep Brain Stimulation for Treatment-Resistant Depression: A Single Center Long-Term Perspective Andrea L. Crowell, Steven J. Garlow, Patricio Riva-Posse and Helen S. Mayberg 43 Autonomy in Depressive Patients Undergoing DBS-Treatment: Informed Consent, Freedom of Will and DBS’ Potential to Restore It Timo Beeker, Thomas E. Schlaepfer and Volker A. Coenen 54 Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies Wissam Deeb, James J. Giordano, Peter J. Rossi, Alon Y. Mogilner, Aysegul Gunduz, Jack W. Judy, Bryan T. Klassen, Christopher R. Butson, Craig Van Horne, Damiaan Deny, Darin D. Dougherty, David Rowell, Greg A. Gerhardt, Gwenn S. Smith, Francisco A. Ponce, Harrison C. Walker, Helen M. Bronte-Stewart, Helen S. Mayberg, Howard J. Chizeck, Jean-Philippe Langevin, Jens Volkmann, Jill L. Ostrem, Jonathan B. Shute, Joohi Jimenez-Shahed, Kelly D. Foote, Aparna Wagle Shukla, Marvin A. Rossi, Michael Oh, Michael Pourfar, Paul B. Rosenberg, Peter A. Silburn, Coralie de Hemptine, Philip A. Starr, Timothy Denison, Umer Akbar, Warren M. Grill and Michael S. Okun 75 Neuromodulation and the Mind-Brain Relation Walter Glannon 78 Understanding Public (Mis)Understanding of tDCS for Enhancement Laura Y. Cabrera and Peter B. Reiner Frontiers in Integrative Neuroscience 4 December 2017 | DBS and Beyond EDITORIAL published: 09 November 2017 doi: 10.3389/fnint.2017.00032 Editorial:
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