Deep Skills: Neuroenhancement and Synaptic Plasticity: the Neuroscience of Movement to Counteract the Effects of Covid 19 Review
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www.kosmospublishers.com [email protected] Review Article Journal of Neurology, Psychiatry and Brain Research JNPBR-150 ISSN: 2641 -6816 Deep skills: Neuroenhancement and Synaptic Plasticity: The neuroscience of movement to counteract the effects of Covid 19 Dario Furnari1,3,4*, Letizia Pappalardo1, Sahara Jean4, Nadya Khan7, Melissa Delaney1, Elena Talyanova1, Monika Milczarek2, Susana Sanchez1, Sebastien Lagree3, Sergey Petrov5, Marey El hamouly6, Khaled Hamlaoui1 1Department of Biomedical Sciences, Uk, Netherlands, Germany 2Department Monroe Medical, Uk 3Department of Lagree Studio, USA, Los Angeles; 4Department of Neuroscience, Australia 5Department of Lotus Academy, Ukraine; 6Department of I.M.A.S, Switzerland 7Department College of Medicine and Health Sciences, United Arab Emirates Received Date: October 05, 2020; Accepted Date: October 08, 2020; Published Date: October 19, 2020 *Corresponding author: Dario Furnari, Department of Biomedical Sciences, Uk, Netherlands, Germany. Email: [email protected] Keywords: Cognitive Exercise; Deep Skills; Exercise sometimes with nuanced details, memory is however the system Physiology; Lagreefitness; Massage ; Mental Health; that allows us to recall the information we have stored and Neurophysiology; Neuroplasticity; Neuroscience; Physical learned from both the external and internal environment. It is Activity; Psychology; Psychomotor Skills; Psychophysiology; the experience that changes us, the contact with the Quantum Physics ; Recognition Memory; Spatial Memory environment that changes our behavior through a series of structural and functional changes in our nervous system. The Deep Skills: Positive Mind Neuroscience of Exercise to last challenge of neuroscience is precisely to better understand Counter Covid 19 the complexity of these mechanisms and how complex phenomena such as learning and memory can occur. Memory and Learning in the time of Covid 19 Although the changes that occur within the individual brain We must begin to lose our memory, even if only cells can be relatively simple, considering that the brain is made occasionally, to understand that memory is what fills our lives. up of many billions of neurons, the overall phenomenon is Life without memory is not life. Our memory is our certainly very complex and makes the isolation and consistency, our reason, our feeling, even our action. Without identification of the specific changes responsible of a certain her we are nothing. really difficult memory. Similarly, although the elements of a specific learning task may be simple, its implications for the Luis Bunuel organism can be very complex (Carlson, 2002). Memory is a wonderful mechanism, a means of transporting From a neurobiological point of view, learning and memory us back in time. We can go back a moment, or a large part of are adaptations to the environment of the brain circuits that life. Sometimes not perfect, sometimes not authentic, allow us to respond appropriately to situations we have 1 | Journal of Neurology, Psychiatry and Brain Research, Volume 2020, Issue 02 Deep skills: Neuroenhancement and Synaptic Plasticity: The Copyright: © neuroscience of movement to counteract the effects of Covid 19 2020 Dario Furnari* previously experienced. Hence, learning (the process by which based on the reorganization of the connections that already exist the nervous system acquires new information and experiences) between the cells, the strength of the synapses can also change and memory (the ability to retain, retain and recall this in adulthood. The cellular mechanisms underlying these information) represent the main mechanisms through which changes are constituted by transient modifications of the environmental events shape behavior. The experiences are not synaptic neurotransmission processes, while in the case of more simply "accumulated" in the brain, but are capable of causing lasting modifications they are constituted by changes in the plastic modifications in our nervous system and of altering the processes of gene expression. Even after development is circuits involved in our most sophisticated functions; in this complete, the ability to change the organization of the nervous way they change the way we act, think, perceive, plan. Although circuits of the cortex is not completely lost, but this ability learning and memory are two closely related functions, they have decreases considerably (Bliss and Collingridge, 1993). temporal sequences and nervous mechanisms that do not always coincide. From a neurophysiological point of view, in fact, the Synaptic Memory and Plasticity learning process is essentially functional, ie entrusted to reverberant circuits and unstable morphological modifications, Synaptic memory and plasticity are studied in depth by while the memory process is structural and presupposes stable neuroscientists who can count today on the use of different morphological modifications. These changes are accompanied methodologies and technologies that range from behavioral by an increase in protein synthesis and consist of an increase in studies to the investigation of gene expression. Thus the number and volume of the dendritic spines (Gasbarri and understanding the changes in synaptic efficacy represents the Tomaz, 2005). The importance of understanding the most well-known field of investigation to date, even if memory mechanisms that underlie the memory process, and the hope of is not just a succession of synaptic events. In a more holistic being able to intervene when they are damaged, is therefore view of the process, memory is determined by the integration easily understood: they depend on the quality of life and the of multiple signals and activities that affect the brain sphere survival of the individual. This type of considerations helps to (attention, intention, interest, emotion), but also what involves make the field of research on the mechanisms underlying the emotional state of the subject (hormonal structure, physical memory particularly active. Many of these studies are carried stress , etc.). Recent data, obtained thanks to the development out on animal models, but one wonders how much these studies of morphometric techniques, underline how experience is also are predictive of human reality both in terms of memory able to provoke changes in the morphology of the neuron and neurobiology (think, for example, of the different and more in particular of the synapse. Three significant examples of extensive development of the cortex in humans), and regarding morpho-functional alterations reported here were chosen. A the effect of drugs of potential therapeutic use in memory first example constituted by the demonstration that an disorders. Some types of memory, however, have common environment rich in visual, auditory, tactile stimuli, etc., characteristics in animals and humans, and animal models make induces changes in the visual cortex level quantifiable as an it easier to study simple forms of learning and memory - such increase in: a) weight and thickness of the cortex; b) size of the as the conditioned blink reflex - which are completely human cell bodies of neurons; c) length and number of dendrites; d) similar to those studied in small mammals. Furthermore, the diameter of synapses and dendritic spines; e) number of preliminary study on the animal very often allows to safeguard synaptic contacts of cortical neurons. These modifications can thousands of human lives and to avoid, for example, the be induced in both young and middle-aged or old animals by experimentation of drugs on the ex-abducted man. Learning is suggesting that neuronal plasticity, very pronounced in the the process by which experiences modify our nervous system developmental age, is maintained throughout life (Turner and and therefore our behavior. The primary function of the ability Greenhough, 1985). A second example is represented by to learn is to develop behaviors suitable for a constantly changes in the hippocampal zone CA1, both in the number of changing environment. Experiences are able to change the way neurons between synapses and dendrites and in the shape of the we perceive, act, think and plan. The ability of our nervous dendritic spines after induction of long-term synaptic system to change in relation to experience is called synaptic enhancement (LTP) (Chang and Greenhough, 1984). The third plasticity and consists of a structural and functional change in example of morpho-functional alteration is provided by the the nervous structures which is reflected in changes in the increase and decrease of pre-synaptic markers in neurons processes of perception, memory, thought, planning and action. (Bailey and Chen, 1983). These different experimental observations clearly indicate how the storage processes are also Learning phenomena can be distinguished in: Non- related to morphological changes at the synaptic level as associative learning: habit and awareness Associative learning: anticipated by the intuitions of Hebb (1949) who proposed that perceptual learning, stimulus response learning (classical / if two neurons are active at the same time, the efficiency of the Pavlonian conditioning), instrumental / operative conditioning synapse is enhanced. Memory is a wonderful artifice of our by trial and error, motor learning, relational learning. Although central nervous system, capable of reconnecting us with our the understanding of the mechanisms responsible for learning past. It allows us to go back a moment, or a long time. But what