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IGF-II) Gene in Villus During 610 Gestational Weeks, Jianhong Chen, Qun Fang, Baojiang Chen, Yi Zhou, and Yanmin Luo Volume 2010, Article ID 965905, 4 Pages

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IGF-II) Gene in Villus During 610 Gestational Weeks, Jianhong Chen, Qun Fang, Baojiang Chen, Yi Zhou, and Yanmin Luo Volume 2010, Article ID 965905, 4 Pages Obstetrics and Gynecology International Epigenetic Regulation in Reproductive Medicine and Gynecologic Cancers Guest Editors: Shi-Wen Jiang, Brian Brost, Sean Dowdy, Xing Xie, and Fan Jin Epigenetic Regulation in Reproductive Medicine and Gynecologic Cancers Obstetrics and Gynecology International Epigenetic Regulation in Reproductive Medicine and Gynecologic Cancers Guest Editors: Shi-Wen Jiang, Brian Brost, Sean Dowdy, Xing Xie, and Fan Jin Copyright © 2010 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in volume 2010 of “Obstetrics and Gynecology International.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Obstetrics and Gynecology International Editorial Board Sean Blackwell, USA Howard D. Homesley, USA Faustino R. Perez-L´ opez,´ Spain Diane C. Bodurka, USA Shi-Wen Jiang, USA Tonse N.K. Raju, USA Curt W. Burger, The Netherlands Marc J. N. C. Keirse, Australia Neal S. Rote, USA Linda D. Cardozo, UK Russell K. Laros Jr., USA Giovanni Scambia, Italy Nancy Chescheir, USA Jonathan Ledermann, UK Peter E. Schwartz, USA Robert Coleman, USA Kimberly K. Leslie, USA John J. Sciarra, USA W. T. Creasman, USA Lawrence D. Longo, USA J. L. Simpson, USA Mary E. D’Alton, USA G. A. Macones, USA Anil Sood, USA Gian Carlo Di Renzo, Italy Everett Magann, USA Wiebren A. A. Tjalma, Belgium Keith A. Eddleman, USA James A. McGregor, USA J. R. Van Nagell, USA Edmund F. Funai, USA Liselotte Mettler, Germany John M. G. van Vugt, The Netherlands Norbert Gleicher, USA Daniel R. Mishell, USA M. A. Williams, USA Thomas Murphy Goodwin, USA Bradley J. Monk, USA Deborah A. Wing, USA WilliamA.Grobman,USA John J. Moore, USA Judith K. Wolf, USA Enrique Hernandez, USA J. C. Morrison, USA Edward V. Younglai, Canada Thomas Herzog, USA Errol R. Norwitz, USA Wolfgang Holzgreve, Switzerland Julian T. Parer, USA Contents Epigenetic Regulation in Reproductive Medicine and Gynecologic Cancers, Shi-Wen Jiang, Brian Brost, Sean Dowdy, Xing Xie, and Fan Jin Volume 2010, Article ID 567260, 2 pages Effects of In Vitro Maturation on Histone Acetylation in Metaphase II Oocytes and Early Cleavage Embryos, Ning Wang, Fang Le, Qi-Tao Zhan, Li Li, Min-Yue Dong, Guo-Lian Ding, Chen-Ming Xu, Shi-Wen Jiang, He-Feng Huang, and Fan Jin Volume 2010, Article ID 989278, 9 pages Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta, Yan-Min Luo, Qun Fang, Hui-Juan Shi, Lin-Huan Huang, Run-Cai Liang, and Guang-Lun Zhuang Volume 2010, Article ID 498574, 5 pages Oxidative Stress and DNA Methylation in Prostate Cancer,KrishnaVanajaDonkena,CharlesY.F.Young, and Donald J. Tindall Volume 2010, Article ID 302051, 14 pages Preimplantation Genetic Screening: An Effective Testing for Infertile and Repeated Miscarriage Patients?, Ning Wang, Ying-Ming Zheng, Lei Li, and Fan Jin Volume 2010, Article ID 120130, 6 pages Study on the Imprinting Status of Insulin-Like Growth Factor II (IGF-II) Gene in Villus during 610 Gestational Weeks, Jianhong Chen, Qun Fang, Baojiang Chen, Yi Zhou, and Yanmin Luo Volume 2010, Article ID 965905, 4 pages Effects of Assisted Reproduction Technology on Placental Imprinted Gene Expression, Yukiko Katagiri, Chizu Aoki, Yuko Tamaki-Ishihara, Yusuke Fukuda, Mamoru Kitamura, Yoichi Matsue, Akiko So, and Mineto Morita Volume 2010, Article ID 437528, 4 pages Specificity of Methylation Assays in Cancer Research: A Guideline for Designing Primers and Probes, Zeinab Barekati, Ramin Radpour, Corina Kohler, and Xiao Yan Zhong Volume 2010, Article ID 870865, 7 pages Epigenetic Regulatory Mechanisms Associated with Infertility, Sheroy Minocherhomji, Prochi F. Madon, and Firuza R. Parikh Volume 2010, Article ID 198709, 7 pages Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis, Oscar Gee-Wan Wong, Zhen Huo, Michelle Kwan-Yee Siu, HuiJuan Zhang, LiLi Jiang, Ester Shuk-Ying Wong, and Annie Nga-Yin Cheung Volume 2010, Article ID 682504, 7 pages Hindawi Publishing Corporation Obstetrics and Gynecology International Volume 2010, Article ID 567260, 2 pages doi:10.1155/2010/567260 Editorial Epigenetic Regulation in Reproductive Medicine and Gynecologic Cancers Shi-Wen Jiang,1 Brian Brost,2 Sean Dowdy,3 Xing Xie,4 and Fan Jin5 1 Mercer University, Macon, GA 31207-0001, USA 2 Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic, USA 3 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Mayo Clinic, USA 4 Women’s Hospital, Zhejiang University School of Medicine, Zhejiang 310006, China 5 Zhejiang University, Hangzhou 310058, China Correspondence should be addressed to Shi-Wen Jiang, jiang [email protected] Received 24 October 2010; Accepted 24 October 2010 Copyright © 2010 Shi-Wen Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Recent progress in the field of epigenetics has provided a new In the first paper entitled “Effects of in vitro maturation on study angle for our research efforts on reproductive medicine histone acetylation in metaphase II oocytes and early cleavage and gynecologic malignancies. We have acquired valuable embryos,” Wang et al. document a reduced expression insight into the regulatory mechanism and biological effects of histone acetyltransferase GCN5 (GCN5) and histone of DNA methylation and histone modification, the two deacetylase 1 (HDAC1) in two-cell embryos but a normal major epigenetic pathways. The newly acquired knowledge level of these enzymes after the two-cell stage. The results effectively complements that gained from the genetic stand- indicate that in vitro maturation could affect protein and point and holds great potential for the prevention, diagnosis, gene expression related to histone acetylation in oocytes and risk assessment, and treatment of these diseases. Specifically, early cleavage embryos. However, by function of selection, the DNA methylation and imprinting mechanisms are parts of the changes could be recovered in late embryo implicated in fertilization, early embryonic development, development. placental function, and pathogenesis of preeclampsia and In the second paper entitled “Imprinting and promoter intrauterine growth retardation. Aberrant DNA methylation usage of insulin-like growth factor II in twin discordant pla- and chromatin modification lead to gene-specific silencing centa,” Luo et al. analyze the imprinting and promoter usage of numerous tumor suppressor genes, DNA repair genes, of IGF-II in placenta of normal twins and twins with weight and steroid hormone receptors. This special issue presents or phenotype discordance and conclude that promoter 3 a collection of peer-reviewed papers focusing on these specific LOI of the IGF-II gene may be closely related to areas. While the issue is not intended as an exhaustive phenotype discordance, but not to weight discordance. representation of all of the potential topics, they nevertheless In the third paper entitled “Oxidative stress and DNA provide insightful and multifaceted information that we methylation in prostate cancer,” Donkena et al. present a consider a pleasure to share with the readers. comprehensive review on the effects of oxidative stress on This special issue includes 9 articles: three of which are DNA methylation and cancer progression, life style and diet related to the IGF-II imprinting in placenta and the effects as factors involved in ontogenesis and epigenetic interference of reproduction procedures on imprinting; two describe epi- for cancer prevention, and DNA methylation as a biomarker genetic mechanisms and genetic test for infertility; another for cancer detection. Updates on the application of DNMT paper documents the effects of in vitro maturation on inhibitors to chemotherapy are also provided. histone acetylation in oocytes and early cleavage embryos; In the fourth paper entitled “Preimplantation genetic two address DNA methylation changes in cancers; one paper screening: an effective testing for infertile and repeated miscar- discusses rational design of primer for methylation assays. riage patients?,” Wang et al. compare results from different 2 Obstetrics and Gynecology International laboratories on preimplantation screening of aneuploidy and assess the efficacy, risks, and benefits of the procedure. They conclude that the use of preimplantation genetic screening should be reconsidered. In the fifth paper entitled “Study on the imprinting status of insulin-like growth factor II (IGF-II) gene in villus during 6–10 gestational weeks,” Chen et al. compared the rate of loss of GF-II imprinting in the placental villous tissues between normal and abnormal embryo development and observed a significantly increased loss of imprinting in the abnormal group, suggesting that the imprinting status of IGF-II may be functionally related to embryo development. In the sixth paper entitled “Effects of assisted reproduction technology on placental imprinted gene expression,” Katagiri et al. investigate the impact of assisted reproduction techniques (ART) on imprinted gene expression in human placenta. Different changes in the mRNA levels of imprinted genes are observed in the ART group compared with the spontaneous conception group, suggesting that ART may modify epige- netic status. In the seventh paper
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