Metro Diabetes Management Class

Total Page:16

File Type:pdf, Size:1020Kb

Metro Diabetes Management Class WELCOME TO METRO DIABETES MANAGEMENT CLASS Kacy Aderhold, MSN, APRN-CNS, CMSRN Metro Diabetes Management INTEGRIS Health is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s commission on accreditation. This activity has been provided through INTEGRIS Health for 5.5 contact hours if all sessions are attended. Participants are required to attend the complete session and turn in an evaluation for each session attended in order to receive contact hours for that session. No influencing relationships or conflicts of interest have been identified in the planning or presentation of this activity. Course Objectives • Discuss the disease process of diabetes • Differentiate between: Pre-diabetes, T1DM, T2DM, Gestational Diabetes, and Stress Induced Hyperglycemia • Identify Core Measures related to in-patient diabetes care • Identify patient education strategies and interventions • Discuss oral agents and insulin preparations for diabetic patients • Demonstrate insulin administration using an insulin pen device • Discuss goals of nutrition for patients with diabetes • Demonstrate knowledge of basic carbohydrate counting • Discuss POC testing and implication of uploading results • Demonstrate understanding of basal/bolus regimen with case scenarios • Recognize acute and chronic complications associated with diabetes • Discuss prevention and treatment of diabetes related complications • Discuss proper EMR documentation for patients with diabetes* • Discuss INTEGRIS protocols including HMP, Hypoglycemia Management Protocol, and Insulin Infusion Protocols* • Discuss INTEGRIS Resources* *Not included in contact hours DISEASE PROCESS Kacy Aderhold, MSN, APRN-CNS, CMSRN What is Diabetes? Diabetes is a metabolic disease resulting in elevated blood glucose levels caused by the body’s complete lack of insulin production, or the cell’s resistance to the circulating insulin. Diabetes Basics The Role of Insulin Prevalence • Diabetes affects 29.1 million people or 9.3% of the U.S. population • Another 79 million have pre-diabetes and are at risk for developing type 2 diabetes. • Diabetes is the seventh leading cause of death in the U.S. • 69,071 death certificates listed DM as cause of death • 234,051 death certificates listed DM as a contributing cause of death • Recent estimates project that as many as one in three American adults will have diabetes in 2050. (CDC, 2014) Prevalence in the U.S. 2008 Age-Adjusted Estimates of the Percentage of Adults with Diagnosed Diabetes (CDC, 2011) Prevalence in Oklahoma 2008 Age-Adjusted Estimates of the Percentage of Adults† with Diagnosed Diabetes in Oklahoma (CDC, 2011) Three Main Types of Diabetes • Type 1: body does not produce insulin • Type 2: body’s cells are resistant to insulin • Gestational: high blood glucose during pregnancy Type 1 Diabetes (T1DM) • Result of body’s failure to produce insulin • Formerly known as juvenile diabetes or Insulin Dependent Diabetes Mellitus (IDDM) • Auto-immune destruction of the β cells of the pancreas • Causes largely unknown- environmental and genetic • Relatives of patients with T1DM have an increased risk for T1DM • 5% of people that have diabetes have Type 1 (CDC, 2014) • Usually a sudden onset Type 1 Diabetes The lack of insulin results in elevated blood sugar because the sugar is not getting into the cell. Type 1 Diabetes Treatment • INSULIN • The pancreas in patients with T1DM does not make insulin, so these patients MUST be on insulin! • Exercise • Nutrition Type 2 Diabetes (T2DM) • Result of the body’s cells developing resistance to the circulating insulin • Formerly known as Non- Insulin Dependent Diabetes Mellitus (NIDDM) or adult-onset diabetes • May have excessive circulating insulin • 90-95% of patients with diabetes have T2DM (CDC, 2014) • Progressive Type 2 Diabetes Glucose cannot enter the cell in spite of insulin because the body’s cells are resistant to the insulin. To overcome the resistance, the pancreas has to produce more insulin to get the sugar into the cell. The pancreas works hard to produce more and more insulin, eventually the pancreas gets tired. That is what makes Type 2 diabetes a progressive disease. What is Diabetes? Risk Factors for T2DM • Primarily genetic • Family history • Member of ethnic group with high prevalence of diabetes • Physical Inactivity • Obesity • History of GDM or delivery of large for gestational age infant • Hypertension • Depression • Low HDL cholesterol • Diagnosis of Polycystic Ovarian Syndrome (PCOS) • Age is no longer a reliable indicator (CDC, 2014) (CDC, 2014) Metabolic Syndrome A combination of metabolic risk factors that predispose individuals to CVD & T2DM, defined as any 3 of the following: • Abdominal obesity, defined as a waist circumference in men ≥102 cm (40 in) and in women ≥88 cm (35 in) • Serum triglycerides ≥150 mg/dL (1.7 mmol/L) or drug treatment for elevated triglycerides • Serum HDL cholesterol <40 mg/dL (1 mmol/L) in men and <50 mg/dL (1.3 mmol/L) in women or drug treatment for low HDL-C • BP ≥130/85 mmHg or drug treatment for elevated BP • Fasting plasma glucose (FPG) ≥100 mg/dL (5.6 mmol/L) or drug treatment for elevated blood glucose (ATPIII, 2001) Type 2 Diabetes Treatment • Exercise • Nutrition • Medications • Oral agents • Insulin Signs and Symptoms of Diabetes • Polyuria • Polydipsia • Polyphagia • Weight loss • Slow healing • Frequent infections • Fatigue These symptoms may be more of a sudden onset for Type 1 and develop more slowly in Type 2 Diagnosis of Diabetes A1C > 6.5 % Fasting Plasma Glucose > 126 mg/dL (FPG) Oral Glucose Tolerance > 200 mg/dL Test (OGTT) 2 hour sample Random Plasma > 200 mg/dL plus Glucose classic symptoms* of hyperglycemia * Classic Symptoms of Diabetes: polyuria, polydipsia, unexplained weight loss (ADA, 2015) So what is a HbA1c? • Also called glycosylated or glycated hemoglobin test. • Measures what percentage of your hemoglobin (a protein in red blood cells that carries oxygen) is coated with sugar (glycated). • A measure of blood glucose levels over the previous 90 days. • Measuring A1C gives a big picture of glucose levels, while a blood glucose check gives a snapshot of that moment. • This number tells about the risk for complications. Research has shown that keeping A1C levels at 7% or lower helps prevent or delay long-term complications of diabetes. • An A1C of 6.5 can be used to diagnose someone with diabetes. This table shows the relationship ↓7 = well controlled between an A1C result and the 7-8.4 = mildly controlled patient’s 8.5-9.9 = moderately estimated controlled average glucose number in mg/dL. ↑10 = severely uncontrolled Fasting vs. Random Blood Glucose Tests Fasting Blood Glucose Random Blood Glucose • Done after not eating for 8 • Taken randomly hours throughout the day • Usually done before • Take into account the breakfast effect of food • Blood glucose is highest • Tells how well the after a meal pancreas is keeping up • If blood glucose is high with the liver before a meal, the pancreas is not keeping up with the food the patient is eating. Gestational Diabetes • When a woman not previously diagnosed with diabetes has high blood glucose levels during pregnancy • Occurs in approximately 2-10% of all pregnancies (CDC, 2012) • Screen at first prenatal visit for those with risk factors and 24-28 weeks gestation for all others OGTT: Oral Glucose Tolerance Test • First test is taken while fasting • The patient drinks a sweet liquid that contains glucose, usually 75 grams of carbohydrates • A series of tests are taken every 30-60 minutes after drinking the drink, up to 3 hours The diagnosis of GDM is made when any of the plasma glucose values are exceeded: (ADA, 2015) Causes The hormones produced Hormones during pregnancy increase the amount of insulin needed to control blood glucose levels. If the body can’t meet this increased need for insulin, women can develop gestational diabetes during the late stages of pregnancy. Risk Factors for Gestational Diabetes • Obesity • First degree relatives with type 2 diabetes • History of abnormal glucose tolerance or poor obstetric outcome • Diagnosis of PCOS • Member of an ethnic group with a high prevalence of DM • Hispanic • African American • Native American • South or East Asian • Pacific Islanders Diabetes Complications in Pregnancy • Poorly controlled diabetes before conception and during the first trimester among women with type 1 diabetes can cause major birth defects and spontaneous abortions • Poorly controlled diabetes during the second and third trimesters can result in excessively large babies, posing a risk to both mother and child. Complications of Gestational Diabetes (cont.) Mother Baby • ↑ risk of pre-eclampsia • Neonatal macrosomia • ↑ risk for C-section • Shoulder dystocia • More likely to develop type • Hypoglycemia after birth 2 diabetes later in life • ↑ risk for childhood obesity • More likely to develop gestational DM in future • ↑ risk for developing type 2 pregnancies diabetes later in life Gestational Diabetes Treatment • Exercise • Nutrition • Insulin • F/U 6-12 weeks post partum for T2DM screening Gestational Diabetes Goals of Control (ACOG, 2005) What is Normal? Euglycemia = normal blood sugar A1C about 5 Fasting plasma glucose 99 or below OGTT 139 or below What is Normal? • The body’s goal is homeostasis. Many hormones work together in the body to regulate blood sugar: Insulin- produced in β-cells of pancreas, gatekeeper for transporting glucose into cells Amylin- produced in β- cells of pancreas, works post-prandial
Recommended publications
  • The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma
    International Journal of Molecular Sciences Review The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma 1, 1, 2 3 Wioletta Rozp˛edek-Kami´nska y , Radosław Wojtczak y, Jacek P. Szaflik , Jerzy Szaflik and Ireneusz Majsterek 1,* 1 Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 90-419 Lodz, Poland; [email protected] (W.R.-K.); [email protected] (R.W.) 2 Department of Ophthalmology, SPKSO Ophthalmic Hospital, Medical University of Warsaw, 03-709 Warsaw, Poland; jacek@szaflik.pl 3 Laser Eye Microsurgery Center, Clinic of Jerzy Szaflik, 00-215 Warsaw, Poland; jerzy@szaflik.pl * Correspondence: [email protected]; Tel.: +48-42-272-53-00 These authors contributed equally to this work. y Received: 27 April 2020; Accepted: 9 June 2020; Published: 11 June 2020 Abstract: Glaucoma is a heterogenous, chronic, progressive group of eye diseases, which results in irreversible loss of vision. There are several types of glaucoma, whereas the primary open-angle glaucoma (POAG) constitutes the most common type of glaucoma, accounting for three-quarters of all glaucoma cases. The pathological mechanisms leading to POAG pathogenesis are multifactorial and still poorly understood, but it is commonly known that significantly elevated intraocular pressure (IOP) plays a crucial role in POAG pathogenesis. Besides, genetic predisposition and aggregation of abrogated proteins within the endoplasmic reticulum (ER) lumen and subsequent activation of the protein kinase RNA-like endoplasmic reticulum kinase (PERK)-dependent unfolded protein response (UPR) signaling pathway may also constitute important factors for POAG pathogenesis at the molecular level.
    [Show full text]
  • CLASSIFICATION of DIABETES MELLITUS 2019 Classification of Diabetes Mellitus ISBN 978-92-4-151570-2
    CLASSIFICATION OF DIABETES MELLITUS 2019 Classification of diabetes mellitus ISBN 978-92-4-151570-2 © World Health Organization 2019 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. Classification of diabetes mellitus. Geneva: World Health Organization; 2019. Licence:CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data. CIP data are available at http://apps.who.int/iris. Sales, rights and licensing. To purchase WHO publications, see http://apps.who.int/bookorders. To submit requests for commercial use and queries on rights and licensing, see http://www.who.int/about/licensing.
    [Show full text]
  • Late Stage Complications of Diabetes and Insulin Resistance
    abetes & Di M f e o t a l b a o Soumya and Srilatha, J Diabetes Metab 2011, 2:9 n l r i s u m o DOI: 10.4172/2155-6156.1000167 J Journal of Diabetes and Metabolism ISSN: 2155-6156 Review Article Open Access Late Stage Complications of Diabetes and Insulin Resistance Soumya D 1* and Srilatha B 1Department of Microbiology, Chaitanya Postgraduate College, Kakatiya University, Warangal, India 2Department of Biotechnology, Presidency College, Bangalore University, India Abstract Diabetes mellitus is considered one of the main threats to human health in the 21st century. Diabetes is a metabolic disorder or a chronic condition where the sugar levels in blood are high. Diabetes is associated with long-term complications that affect almost every part of the body and often leads to blindness, heart and blood vessel disease, stroke, kidney failure, amputations, and nerve damage. Also it is associated with significantly accelerated rates of several debilitating microvascular complications such as nephropathy, retinopathy, and neuropathy, and macrovascular complications such as atherosclerosis and stroke. In the present article it has been discussed about the resistance of insulin and its consequences in diabetic patients. Insulin resistance results in various disorders. Metabolic syndrome is predicted to become a major public health problem in many developed, as well as developing countries. Keywords: Diabetes; Complications; Insulin; Insulin resistance; [6] characterized by the expansion of pathogenic T effector cells metabolic syndrome which cause the irreversible destruction of insulin producing β cells and thereby limits insulin production and glucose homeostasis [7]. A Abbreviations: DM: Diabetes mellitus; T2D: Type2 diabetes; Type membrane bound protein expressed by the islet cells is shown to act 2 diabetes mellitus (T2DM); Impaired glucose tolerance (IGT); CVD: as a major auto antigen in T1D [8].
    [Show full text]
  • Type 2 Diabetes: One Disease, Many Pathways
    bioRxiv preprint doi: https://doi.org/10.1101/648816; this version posted May 24, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Type 2 Diabetes: One Disease, Many Pathways Joon Ha Arthur Sherman Laboratory of Biological Modeling National Institutes of Health Bethesda, MD USA Abstract (248 words) Diabetes is a chronic, progressive disease that calls for longitudinal data and analysis. We introduce a longitudinal mathematical model that is capable of representing the metabolic state of an individual at any point in time during their progression from normal glucose tolerance to type 2 diabetes (T2D) over a period of years. As an application of the model, we account for the diversity of pathways typically followed, focusing on two extreme alternatives, one that goes through impaired fasting glucose (IFG) first, and one that goes through impaired glucose tolerance (IGT) first. These two pathways are widely recognized to stem from distinct metabolic abnormalities in hepatic glucose production and peripheral glucose uptake, respectively. We confirm this but go beyond to show that IFG and IGT lie on a continuum ranging from high hepatic insulin resistance and low peripheral insulin resistance to low hepatic resistance and high peripheral resistance. We show that IFG generally incurs IGT, and IGT generally incurs IFG on the way to T2D, highlighting the difference between innate and acquired defects and the need to assess patients early to determine their underlying primary impairment. We illustrate the relevance of this for patient stratification by simulating the effects of properly and improperly targeted therapies.
    [Show full text]
  • Quick Tip Guide: Diabetes
    QUICK TIP GUIDE: DIABETES SHNIC The body The digestive tract breaks down carbs into glucose. Glucose is a form of sugar that enters the bloodstream. Insulin, a hormone, then helps cells in the body to absorb this glucose and use it for energy. What is diabetes? • A chronic disease in which blood glucose level are above normal rates. • A disorder of metabolism; the way the body uses digested food for energy. • The body doesn’t produce enough insulin or insulin doesn’t work properly. The Basics • Insulin • A hormone produced by the pancreas that is responsible for regulating blood glucose levels. • The “key” in allowing glucose to move from blood into the cells • So what’s the problem? • In diabetes, the body makes too little/no insulin or the body doesn’t use the insulin properly. Lack of insulin Increase in Glucose The Basics • Complications • High blood glucose can damage nerves and blood vessels causing heart disease, stroke, kidney problems, blindness, and amputations. • Others issues include susceptibility to other disease, loss of mobility, depression and pregnancy complications. The Basics • Type 1 Diabetes • An auto-immune disease where the body’s immune system attacks and destroys the body’s insulin producing cells (also known as beta cells in pancreas). • Could be caused by a genetic predisposition or inherited factor, and • Individuals could be “genetically sensitive” to environmental triggers like viruses, food or toxins that make them at risk. • The pancreas then produces little or no insulin. • “Insulin-dependent” diabetic that now must take insulin everyday. • Cannot be prevented or cured. • Usually occurs in children and requires lifelong management.
    [Show full text]
  • Understanding Common Eye Diseases
    UNDERSTANDING COMMON EYE DISEASES INTRODUCTION Diseases of the eye are very common and if a Certified Nursing Assistant (CNA) is working with an elderly population it is very likely that some of these patients will have one or more of ocular diseases. Vision slowly changes as we age. There are some eye problems that are almost an inevitable part of growing old: as dry eyes, floaters (tiny spots that seem to “float” across the field of vision when someone is exposed to bright lights), and presbyopia, a medical term that means an inability to see object or fine print at close range. These problems are inconvenient but they are not dangerous and they can be easily managed. However, aging is also associated with some very serious eye diseases: cataracts, diabetic retinopathy, glaucoma, and macular degeneration. These eye diseases can significantly impair someone's vision, cause blindness, and/or interfere with the activities of daily living. Because these eye diseases are relatively common and because of their effect on vision and the ability to perform self-care, CNAs should have a basic understanding of cataracts, diabetic retinopathy, glaucoma, and macular degeneration, how they affect vision, and know how to assist someone with impaired vision. STATEMENT OF PURPOSE This module is intended to provide CNAs with basic information about common eye diseases and instruct CNAs on how to provide assistance to someone who has impaired vision. cnaZone.com cnaZone.com cnaZone.com cnaZone.com cnaZone.com cnaZone.com THE BASICS OF VISION: HOW OUR EYES WORK Our eyes work by taking in visual data from the world and sending this information to a specific section of the brain.
    [Show full text]
  • Diabetes Resource Guide
    Diabetes Resource Guide 1st Edition Where to Find Diabetes Care, Education, & Support Services in Will County, Illinois Developed by the Will County MAPP Collaborative Diabetes Workgroup September 1, 2018 This guide was created as a resource to help Will County, Illinois residents to more effectively manage diabetes and reduce complications associated with diabetes. The information in this booklet is not a substitute for medical advice or treatment. If you feel you may be at risk for diabetes or if you have diabetes, consult with your doctor or health care professional. We are not necessarily endorsing or recommending specific providers listed in this guide. They are listed as possible places for you to contact. If you have updates to the resource guide please contact: [email protected] This guide was created to help you reduce your risk of diabetes or help you manage your diabetes. TABLE OF CONTENTS I WHAT YOU NEED TO KNOW II TYPES OF DIABETES III HOW DO I KNOW IF I HAVE DIABETES? IV STAYING ON TOP OF IT V TEAM BUILDING VI WHERE TO GO VII DO YOU HAVE AN APP FOR THAT? VIII WHAT DOES THAT MEAN? More than a Disease Diabetes is not only a disease in itself, it can lead to other serious conditions that can shorten life or dramatically impact your life. The American Diabetes Association reports that 30.3 million people in the United States have diabetes. 48% of all adults 65 and over have diabetes. An estimated 33.9% of adults have prediabetes, based on their fasting glucose or A1C.
    [Show full text]
  • Individuals with Chronic Conditions Subcommittee Presentation
    Meeting 4 Individuals with Chronic Conditions Chair: David Buchner Members: Bill Kraus, Rich Macko, Anne McTiernan, Linda Pescatello, Ken Powell Individuals with Chronic Conditions Subcommittee • July 19-21, 2017 Experts and Consultants • Consultants: – Virginia Byers Kraus, M.D., Ph.D. – Duke University School of Medicine – Christine M. Friedenreich, Ph.D. – Alberta Health Services – Ronald J. Sigal, M.D., M.P.H. – University of Calgary 51 Individuals with Chronic Conditions Subcommittee • July 19-21, 2017 Overview: Question #1 1. Among cancer survivors, what is the relationship between physical activity and (1) all-cause mortality, (2) cancer-specific mortality, or (3) risk of cancer recurrence or second primary cancer? • In March 2017, presented findings for breast cancer and colorectal cancer. • Today, findings for prostate cancer are presented. • Based upon results of searches, no other cancers have enough evidence to allow review as part of Q1. 52 Individuals with Chronic Conditions Subcommittee • July 19-21, 2017 Overview: Questions 2-4 Q2-Q4 have similar structure: In people with chronic conditions, what is the relationship between physical activity and (1) risk of co-morbid conditions, (2) physical function, (3) health-related quality of life, and (4) disease progression? Q2 = Osteoarthritis Q3 = Hypertension Q4 = Type 2 diabetes Questions generally to be answered: “systematic reviews, meta-analyses, pooled analyses, and/or high-quality existing reports.” Except made two changes to Q2 on osteoarthritis: 1) Added an additional
    [Show full text]
  • Common Eye Diseases
    COMMON EYE DISEASES Abstract Diseases of the eye are a common medical condition. Vision slowly changes when people age. Aging is associated with serious eye diseases such as cataracts, diabetic retinopathy, glaucoma, and macular degeneration. These eye diseases can significantly impair a person's vision, cause blindness, and/or interfere with the activities of daily living. These eye diseases are relatively common and have an effect on vision and the ability of a patient to perform self-care. A basic understanding of common eye diseases and how they affect vision, as well as an overview of how to assist someone with impaired vision are discussed. Learning Objectives: 1. Identify the common eye diseases and how they affect vision. 2. Describe the two forms of macular degeneration. 3. Describe the purpose of the Snellen test. 4. Describe how age-related macular degeneration is diagnosed 5. Define the use of the Amster Grid. 1 cnaZone.com cnaZone.com cnaZone.com cnaZone.com cnaZone.com cnaZone.com Introduction Diseases of the eye are a common medical condition. When assisting an elderly population, it is very likely that some of these patients will have one or more ocular diseases. Vision slowly changes when people age. There are some eye problems that are almost an inevitable part of growing old, such as dry eyes, floaters (tiny spots that seem to “float” across the field of vision when someone is exposed to bright lights), and presbyopia, a medical term that means an inability to see object or fine print at close range. These problems are inconvenient but they are not dangerous and they can be managed.
    [Show full text]
  • CHAPTER 37 PREVENTION of TYPE 1 DIABETES Jay S
    CHAPTER 37 PREVENTION OF TYPE 1 DIABETES Jay S. Skyler, MD, MACP, Jeffrey P. Krischer, PhD, Dorothy J. Becker, MD, MBBCh, and Marian Rewers, MD, PhD Dr. Jay S. Skyler is Professor of Medicine at the Diabetes Research Institute, University of Miami Miller School of Medicine, University of Miami, Miami, FL. Dr. Jeffrey P. Krischer is Professor at the University of South Florida College of Medicine, and Director of the USF Diabetes Center and USF Health Informatics Institute, Tampa, FL. Dr. Dorothy J. Becker is Professor of Pediatrics in the Division of Endocrinology and Diabetes, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA. Dr. Marian Rewers is Professor of Pediatrics and Medicine at the Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO. SUMMARY Type 1 diabetes is a progressive disease. There is a genetic predisposition to type 1 diabetes, particularly conferred by alleles present within the major histocompatibility complex (HLA region) on the short arm of chromosome six. It is thought that in susceptible indi- viduals, an environmental trigger initiates an immune response. Immune infiltration into pancreatic islets results in beta cell damage, impairment of beta cell function, and potential destruction of beta cells. One would expect that if type 1 diabetes is an immunologi- cally mediated disease, then immune intervention should alter the natural history of the disease and potentially abrogate the clinical syndrome. Intervention trials have been conducted at a number of stages of the disease process. Primary prevention trials have been conducted in individuals with a genetic predisposition who have not yet developed immunologic markers (“Pre-Stage 1”).
    [Show full text]
  • GLOBAL REPORT on DIABETES WHO Library Cataloguing-In-Publication Data
    GLOBAL REPORT ON DIABETES WHO Library Cataloguing-in-Publication Data Global report on diabetes. 1. Diabetes Mellitus – epidemiology. 2. Diabetes Mellitus – prevention and control. 3. Diabetes, Gestational. 4. Chronic Disease. 5. Public Health. I. World Health Organization. ISBN 978 92 4 156525 7 (NLM classification: WK 810) © World Health Organization 2016 All rights reserved. Publications of the World Health Organization are available on the WHO website (http://www.who.int) or can be purchased from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; email: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for non-commercial distribution – should be addressed to WHO Press through the WHO website (http://www.who.int/about/licensing/ copyright_form/index.html). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
    [Show full text]
  • Latent Autoimmune Diabetes in the Young
    lesson of the month (2) S Zachariah Lesson MRCP, Specialist Registrar in Latent autoimmune diabetes A 15-year-old asymptomatic Caucasian girl was Diabetes and in the young found to have elevated random blood glucose on Endocrinology routine testing. Urine testing revealed moderate MO Sharfi This case represents latent autoimmune ketonuria in addition to glycosuria. She had a body 2 MRCP, Specialist diabetes in the young (LADY), and mass index (BMI) of 21.4 kg/m , blood pressure of Registrar in demonstrates that autoimmune diabetes can 118/90 mmHg, random capillary blood glucose Diabetes and be slowly progressive even in younger (CBG) 16.8 mmol/l (confirmed with venous sample) Endocrinology patients with insulin independency period with no evidence of diabetic complications. Her SS Nussey lasting for more than two years. sister had type 1 diabetes and she had presented with MD FRCP, Professor diabetic ketoacidosis at the age of 18 years. She was of Endocrinology on basal bolus insulin regimen and had never been off insulin. G Bano MD FRCP, Consultant in Investigations on our patient showed positive β Diabetes and Type 1 diabetes results from cell destruction which GAD antibodies 10.0 U/ml (0–1), positive islet cell Endocrinology can be immune mediated or idiopathic. Immune- antibodies and negative insulin antibodies. Anti- mediated diabetes accounts for only 5–10% of those bodies for coeliac disease were negative. Fasting Department of with diabetes. It results from a cell-mediated autoim- C-peptide was 451 pmol/l and insulin 49 pmol/l. Cellular and mune destruction of the β cells.1,2 Markers of Measurable C-peptide level suggested residual β cell Molecular Medicine, St immune destruction include presence of autoanti- function.
    [Show full text]