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Wadsworth Center Therapeutic Substance Monitoring Proficiency Testing – January 25, 2010

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Wadsworth Center Therapeutic Substance Monitoring Proficiency Testing – January 25, 2010 New York State Department of Health – Wadsworth Center Therapeutic Substance Monitoring Proficiency Testing – January 25, 2010 Summary of Participant Performance (Mean and Standard Deviation) Acetaminophen (mg/L) Specimen: T31 Specimen: T32 Specimen: T33 Specimen: T34 Specimen: T35 Number [Code] Instrument or Reagent System -------------- -------------- -------------- -------------- -------------- ------- ------------------------------------- 82.35 ± 4.01 152.62 ± 7.45 122.58 ± 6.70 63.66 ± 3.11 39.05 ± 2.00 n = 221 [---] All Methods & Instruments 78.1 146.4 117.0 60.1 38.7 [---] Weigh-in Value <Instruments> 73.87 ± 1.13 138.45 ± 2.30 110.35 ± 1.58 56.50 ± 1.22 34.15 ± 0.41 n = 4 [ABH] Abbott Architect 81.75 ± 4.18 156.47 ± 5.12 123.08 ± 9.23 63.00 ± 3.12 40.20 ± 2.58 n = 11 [ABB] Abbott AxSym 79.58 ± 4.86 152.37 ± 7.67 123.34 ± 8.61 64.06 ± 3.94 37.95 ± 1.13 n = 5 [ABG] Abbott TDX FLX 77.36 ± 3.86 142.43 ± 5.65 113.67 ± 5.63 58.75 ± 3.11 35.29 ± 2.46 n = 9 [OLC] Beckman Coulter AU Chemistry System 87.03 ± 2.47 157.54 ± 4.93 127.76 ± 4.17 67.76 ± 1.84 39.33 ± 4.04 n = 4 [BCS] Beckman Coulter CX 81.14 ± 4.13 152.48 ± 5.80 122.09 ± 5.42 63.34 ± 3.33 39.13 ± 3.42 n = 12 [BCX] Beckman Coulter LX-20 82.05 ± 4.32 151.03 ± 5.65 120.47 ± 3.76 63.02 ± 2.52 38.90 ± 2.51 n = 10 [BCG] Beckman Coulter UniCel DxC 600 81.32 ± 4.17 151.70 ± 6.90 124.22 ± 4.69 63.60 ± 3.16 38.44 ± 2.62 n = 15 [BCH] Beckman Coulter UniCel DxC 800 85.53 ± 0.84 161.69 ± 1.41 128.71 ± 1.92 66.28 ± 1.50 39.82 ± 0.40 n = 4 [JJE] Ortho Vitros 250/350/950 86.35 ± 1.91 161.12 ± 2.55 128.80 ± 1.92 66.25 ± 1.29 39.53 ± 0.87 n = 25 [JJF] Ortho Vitros 5,1FS 60.72 ± 2.39 118.58 ± 4.93 94.44 ± 4.35 46.65 ± 2.37 25.43 ± 1.14 n = 7 [ROC] Roche cobas c501 62.21 ± 1.88 117.87 ± 4.40 93.09 ± 3.12 46.29 ± 1.61 27.53 ± 1.06 n = 12 [ROT] Roche Cobas INTEGRA 55.57 ± 1.90 107.71 ± 2.66 85.70 ± 2.49 41.94 ± 1.35 23.86 ± 0.77 n = 11 [ROD] Roche MODULAR D/P 84.65 ± 1.13 157.24 ± 2.11 126.52 ± 1.57 65.00 ± 1.11 39.97 ± 0.85 n = 7 [BYE] Siemens ADVIA 1800 78.75 ± 5.58 145.78 ± 9.35 116.75 ± 7.85 60.59 ± 3.26 37.77 ± 2.76 n = 3 [BYB] Siemens ADVIA 2400 81.64 ± 1.68 150.83 ± 2.80 121.25 ± 2.23 63.08 ± 1.40 39.09 ± 0.86 n = 61 [DUD] Siemens Dimension 83.19 ± 1.85 150.85 ± 2.81 122.04 ± 1.73 64.38 ± 1.80 40.37 ± 1.20 n = 11 [DUT] Siemens Dimension Vista <Reagents> 80.13 ± 4.73 152.03 ± 8.45 121.04 ± 9.14 62.09 ± 3.93 38.44 ± 2.86 n = 21 [AB1] Abbott 82.08 ± 4.39 152.46 ± 6.27 123.04 ± 5.67 63.73 ± 3.37 38.71 ± 3.05 n = 42 [BC1] Beckman Coulter 76.33 ± 3.93 141.59 ± 5.72 112.10 ± 5.34 58.74 ± 3.43 34.81 ± 2.64 n = 7 [OL1] Beckman Coulter AU Series 86.32 ± 1.76 161.47 ± 2.62 128.91 ± 1.97 66.42 ± 1.44 39.58 ± 0.84 n = 31 [JJ1] Ortho Clinical Diagnostics 60.72 ± 2.39 118.58 ± 4.93 94.44 ± 4.35 46.65 ± 2.37 25.43 ± 1.14 n = 7 [RO4] Roche cobas c501 55.57 ± 1.90 107.71 ± 2.66 85.70 ± 2.49 41.94 ± 1.35 23.86 ± 0.77 n = 11 [RO2] Roche Hitachi and Modular D/P 62.21 ± 1.88 117.87 ± 4.40 93.09 ± 3.12 46.29 ± 1.61 27.53 ± 1.06 n = 12 [RO1] Roche Integra and MIRA 84.57 ± 1.41 157.16 ± 2.36 126.34 ± 2.09 64.59 ± 1.54 39.84 ± 1.22 n = 12 [BY1] Siemens ADVIA/ADVIA Centaur 81.88 ± 1.79 150.89 ± 2.79 121.42 ± 2.18 63.28 ± 1.52 39.24 ± 0.99 n = 71 [DA1] Siemens Dimension/Stratus 75.89 ± 7.50 144.19 ± 3.69 115.82 ± 4.83 57.58 ± 2.66 36.25 ± 0.54 n = 3 [SY5] Syva Emit tox New York State Department of Health – Wadsworth Center Therapeutic Substance Monitoring Proficiency Testing – January 25, 2010 Summary of Participant Performance (Mean and Standard Deviation) Carbamazepine (mg/L) Specimen: T31 Specimen: T32 Specimen: T33 Specimen: T34 Specimen: T35 Number [Code] Instrument or Reagent System -------------- -------------- -------------- -------------- -------------- ------- ------------------------------------- 6.58 ± 0.56 3.42 ± 0.37 9.73 ± 0.78 6.40 ± 0.55 13.36 ± 1.04 n = 247 [---] All Methods & Instruments 6.9 3.7 10.1 6.7 13.9 [---] Weigh-in Value <Instruments> 7.28 ± 0.41 3.92 ± 0.24 10.50 ± 0.45 7.04 ± 0.56 14.73 ± 0.77 n = 3 [ABH] Abbott Architect 6.61 ± 0.27 3.51 ± 0.21 9.60 ± 0.58 6.38 ± 0.27 13.31 ± 0.51 n = 20 [ABB] Abbott AxSym 6.62 ± 0.24 3.57 ± 0.14 9.53 ± 0.34 6.18 ± 0.32 12.71 ± 0.74 n = 3 [ABG] Abbott TDX FLX 6.89 ± 0.31 3.68 ± 0.20 10.20 ± 0.36 6.59 ± 0.26 13.91 ± 0.50 n = 13 [OLC] Beckman Coulter AU Chemistry System 6.54 ± 0.18 3.48 ± 0.32 9.80 ± 0.40 6.63 ± 0.32 12.87 ± 0.43 n = 4 [BCS] Beckman Coulter CX 6.68 ± 0.40 3.16 ± 0.31 9.73 ± 0.43 6.45 ± 0.44 12.97 ± 0.91 n = 11 [BCX] Beckman Coulter LX-20 6.66 ± 0.41 3.18 ± 0.22 9.69 ± 0.50 6.47 ± 0.35 13.11 ± 0.70 n = 9 [BCG] Beckman Coulter UniCel DxC 600 6.68 ± 0.43 3.18 ± 0.26 9.75 ± 0.51 6.44 ± 0.28 13.08 ± 0.95 n = 19 [BCH] Beckman Coulter UniCel DxC 800 5.45 ± 0.37 3.00 ± 0.00 8.01 ± 0.52 4.92 ± 0.29 11.53 ± 0.56 n = 20 [JJF] Ortho Vitros 5,1FS 7.30 ± 0.14 4.22 ± 0.23 10.78 ± 0.30 7.21 ± 0.20 14.78 ± 0.34 n = 9 [ROC] Roche cobas c501 6.65 ± 0.22 3.49 ± 0.11 9.84 ± 0.28 6.44 ± 0.18 13.82 ± 0.57 n = 19 [ROT] Roche Cobas INTEGRA 7.59 ± 0.37 4.30 ± 0.18 10.96 ± 0.50 7.40 ± 0.45 14.75 ± 0.39 n = 13 [ROD] Roche MODULAR D/P 5.35 ± 0.30 2.87 ± 0.25 8.36 ± 0.45 5.22 ± 0.13 11.34 ± 0.35 n = 4 [BYE] Siemens ADVIA 1800 6.41 ± 0.67 3.38 ± 0.37 9.35 ± 0.87 6.31 ± 0.61 12.90 ± 1.16 n = 18 [COB] Siemens ADVIA Centaur 6.53 ± 0.27 3.47 ± 0.17 9.81 ± 0.35 6.37 ± 0.23 13.53 ± 0.44 n = 60 [DUD] Siemens Dimension 6.73 ± 0.36 3.52 ± 0.16 9.90 ± 0.42 6.41 ± 0.32 13.44 ± 0.51 n = 12 [DUT] Siemens Dimension Vista <Reagents> 6.64 ± 0.31 3.56 ± 0.23 9.69 ± 0.61 6.38 ± 0.33 13.34 ± 0.70 n = 26 [AB1] Abbott 6.65 ± 0.38 3.19 ± 0.29 9.73 ± 0.47 6.47 ± 0.32 13.03 ± 0.85 n = 43 [BC1] Beckman Coulter 7.03 ± 0.25 3.74 ± 0.18 10.35 ± 0.39 6.68 ± 0.23 14.07 ± 0.73 n = 7 [OL1] Beckman Coulter AU Series 7.56 ± 0.23 4.25 ± 0.12 10.86 ± 0.32 7.44 ± 0.35 14.73 ± 0.41 n = 4 [MG1] Microgenics CEDIA 5.48 ± 0.38 3.00 ± 0.00 8.01 ± 0.57 4.94 ± 0.35 11.49 ± 0.66 n = 23 [JJ1] Ortho Clinical Diagnostics 7.30 ± 0.14 4.22 ± 0.23 10.78 ± 0.30 7.21 ± 0.20 14.78 ± 0.34 n = 9 [RO4] Roche cobas c501 7.71 ± 0.38 4.36 ± 0.21 11.22 ± 0.47 7.50 ± 0.41 14.83 ± 0.34 n = 6 [RO2] Roche Hitachi and Modular D/P 6.65 ± 0.22 3.49 ± 0.11 9.84 ± 0.28 6.44 ± 0.18 13.82 ± 0.57 n = 19 [RO1] Roche Integra and MIRA 6.12 ± 0.76 3.23 ± 0.42 9.03 ± 0.90 6.06 ± 0.74 12.59 ± 1.25 n = 25 [BY1] Siemens ADVIA/ADVIA Centaur 6.59 ± 0.36 3.51 ± 0.18 9.83 ± 0.39 6.38 ± 0.28 13.48 ± 0.50 n = 31 [DA4] Siemens Dimension PETINIA 6.54 ± 0.26 3.45 ± 0.17 9.82 ± 0.35 6.37 ± 0.22 13.53 ± 0.42 n = 39 [DA1] Siemens Dimension/Stratus 6.72 ± 0.31 3.64 ± 0.20 10.06 ± 0.26 6.52 ± 0.24 13.78 ± 0.20 n = 5 [SY4] Syva Emit 2000 New York State Department of Health – Wadsworth Center Therapeutic Substance Monitoring Proficiency Testing – January 25, 2010 Summary of Participant Performance (Mean and Standard Deviation) Digoxin (µg/L) Specimen: T31 Specimen: T32 Specimen: T33 Specimen: T34 Specimen: T35 Number [Code] Instrument or Reagent System -------------- -------------- -------------- -------------- -------------- ------- ------------------------------------- 1.852 ± 0.153 1.363 ± 0.152 2.747 ± 0.209 0.682 ± 0.117 1.484 ± 0.155 n = 294 [---] All Methods & Instruments 1.8 1.4 2.7 0.7 1.5 [---] Weigh-in Value <Instruments> 1.815 ± 0.046 1.395 ± 0.030 2.664 ± 0.058 0.639 ± 0.052 1.497 ± 0.030 n = 4 [ABH] Abbott Architect 1.867 ± 0.131 1.337 ± 0.106 2.787 ± 0.140 0.663 ± 0.060 1.444 ± 0.111 n = 18 [ABB] Abbott AxSym 1.779 ± 0.101 1.367 ± 0.100 2.576 ± 0.152 0.762 ± 0.075 1.476 ± 0.103 n = 11 [SAA] Beckman Coulter ACCESS 1.682 ± 0.152 1.186 ± 0.126 2.487 ± 0.197 0.570 ± 0.088 1.328 ± 0.116 n = 15 [OLC] Beckman Coulter AU Chemistry System 1.746 ± 0.107 1.286 ± 0.127 2.500 ± 0.000 0.636 ± 0.109 1.326 ± 0.110 n = 5 [BCS] Beckman Coulter CX 1.591 ± 0.147 1.138 ± 0.107 2.452 ± 0.149 0.534 ± 0.133 1.262 ± 0.122 n = 11 [BCX] Beckman Coulter LX-20 1.645 ± 0.114 1.187 ± 0.134 2.491 ± 0.143 0.596 ± 0.091 1.283 ± 0.094 n = 11 [BCG] Beckman Coulter UniCel DxC 600 1.649 ± 0.130 1.203 ± 0.140 2.552 ± 0.157 0.595 ± 0.114 1.300 ± 0.144 n = 16 [BCH] Beckman Coulter UniCel DxC 800 1.846 ± 0.149 1.377 ± 0.163 2.679 ± 0.170 0.752 ± 0.156 1.527 ± 0.168 n = 4 [BCU] Beckman Coulter UniCel DxI 800 1.706 ± 0.093 1.144 ± 0.144 2.582 ± 0.138 0.528 ± 0.148 1.291 ± 0.163 n = 5 [JJE] Ortho Vitros 250/350/950 1.731 ± 0.145 1.198 ± 0.134 2.669 ± 0.153 0.547 ± 0.110 1.332 ± 0.166 n = 26 [JJF] Ortho Vitros 5,1FS 1.886 ± 0.111 1.367 ± 0.081 2.865 ± 0.116 0.749 ± 0.068 1.509 ± 0.075 n = 12 [ROC] Roche cobas c501 1.927 ± 0.082 1.451 ± 0.134 2.886 ± 0.165 0.791 ± 0.113 1.574 ± 0.074 n = 13 [ROT] Roche Cobas INTEGRA 1.925 ± 0.125 1.443 ± 0.168 2.801 ± 0.149 0.774 ± 0.130 1.561 ± 0.130 n = 13 [ROD] Roche MODULAR D/P 1.908 ± 0.053 1.500 ± 0.075 2.700 ± 0.075 0.609 ± 0.049 1.585 ± 0.041 n = 4 [BYE] Siemens ADVIA 1800 1.872 ± 0.068 1.387 ± 0.092 2.708 ± 0.098 0.676 ± 0.066 1.508 ± 0.085 n = 24 [COB] Siemens ADVIA Centaur 1.917 ± 0.067 1.422 ± 0.059 2.853 ± 0.090 0.720 ± 0.063 1.557 ± 0.066 n = 68 [DUD] Siemens Dimension 1.977 ± 0.077 1.500 ± 0.000 2.940 ± 0.100 0.717 ± 0.041 1.600 ± 0.000 n = 11 [DUT] Siemens Dimension Vista 2.071 ± 0.162 1.579 ± 0.092 3.122 ± 0.317 0.801 ± 0.101 1.746 ± 0.172 n = 7 [DPD] Siemens Immulite 2000 <Reagents> 1.852 ± 0.112 1.356 ± 0.102 2.752 ± 0.152 0.660 ± 0.063 1.452 ± 0.098 n = 23 [AB1] Abbott 1.681 ± 0.148 1.234 ± 0.158 2.532 ± 0.159 0.630 ± 0.139 1.334 ± 0.150 n = 58 [BC1] Beckman Coulter 1.693 ± 0.145 1.154 ± 0.098 2.490 ± 0.187 0.553 ± 0.078 1.300 ± 0.098 n = 11 [OL1] Beckman Coulter AU Series 1.736 ± 0.141 1.191 ± 0.132 2.663 ± 0.156 0.543 ± 0.113
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