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US 20170296568A1 ( 19) United States (12 ) Patent Application Publication (10 ) Pub. No. : US 2017/ 0296568 A1 KATAKURA et al. (43 ) Pub . Date : Oct. 19 , 2017 ( 54 ) SIRTUIN GENE POTENTIATOR , AND Publication Classification PHARMACEUTICAL PRODUCT, COSMETIC (51 ) Int . Ci. PRODUCT, AND FOOD PRODUCT USING A61K 31 / 7048 (2006 . 01 ) SAME A61K 8 / 97 ( 2006 .01 ) A61K 8 /60 ( 2006 .01 ) (71 ) Applicants :MORISHITA JINTAN CO . , LTD . , A61K 36 / 185 ( 2006 . 01 ) Osaka ( JP ) ; KYUSHU UNIVERSITY , A23L 33/ 105 ( 2006 .01 ) NATIONAL UNIVERSITY A61Q 19 /00 ( 2006 .01 ) CORPORATION , Fukuoka ( JP ) A23L 2 / 52 (2006 . 01) ( 52 ) U . S . CI. (72 ) Inventors: Yoshinori KATAKURA , Fukuoka ( JP ) ; CPC . .. A61K 31 / 7048 ( 2013 . 01 ) ; A610 19 / 007 Takeru SUYAMA , Osaka ( JP ) ; ( 2013 . 01 ) ; A61K 8 / 97 ( 2013 .01 ) ; A23L 2 / 52 Norihisa NISHIDA , Osaka ( JP ) (2013 .01 ) ; A61K 36 / 185 (2013 .01 ) ; A23L 33 / 105 (2016 .08 ) ; A61K 8 /60 ( 2013 . 01 ) ; A23V 2002 /00 ( 2013 .01 ) ; A61K 2800 /78 (2013 .01 ) ( 21 ) Appl. No. : 15 /628 ,684 ( 57 ) ABSTRACT Disclosed are a method for potentiating a sirtuin gene in a living body , provided to the living body as a pharmaceutical (22 ) Filed: Jun . 21, 2017 product, a cosmetic product, or a food product including a sirtuin gene potentiator. The sirtuin gene potentiator of the present invention contains a given polyphenol and /or terpe Related U . S . Application Data noid as an active component. The polyphenol and / or the (63 ) Continuation of application No. 14 /427 , 312 , filed on terpenoid can be contained in the form of a plant such as Mar. 11, 2015 , filed as application No . PCT / JP2013 / pomegranate or a plant extract thereof. The sirtuin gene 074939 on Sep . 13 , 2013 . potentiator of the present invention is available from a familiar material to avoid concerns such as side effects on ( 30) Foreign Application Priority Data the human body in advance. Such a sirtuin gene potentiator is useful as a novel material in the fields of pharmaceutical Sep . 13, 2012 ( JP ) .. .. 2012 - 201899 products , cosmetic products , and food products . Patent Application Publication Oct. 19 , 2017 Sheet 1 of 4 US 2017 /0296568 A1 ulash viele eebel Batarde wwwwwwww * * * * trai * v w * Glycynicin * * * palmitateKaltweol KatiwapalmitateCélestal * Caiete Ostunicillidalatin wwwwwwwwwwww very ???? wwwwwwwwwvvwvww* % w vvvvvv * v TilasideSkrelarina acidRosmarinic wwwww 1Bugenin:5Onnaintarinin wmanvivvvvvvvvvvvvvve w 1Telliminerendia N* * UDAPogle Wwwww Polin . Casild * *wwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwww * StadtbanedeScitatacasele * 1 TrosalActeonide * Hydroxyturosal?????? minutos 88 136 os socok syHHHHHHHHHHHHHHH w Patent Application Publication Oct. 19 , 2017 Sheet 2 of 4 US 2017 /0296568 A1 w FZLUQUOCO jame Cafestol coracocerceariMAA Fisetin . Eugenin V on www wwwwwwwwwwwww Punicatogin At1 * * Mm mm Resveratrol sa Uritreated Bigy 10 janez votesbloxo SUIQ papujen Fig.2 Patent Application Publication Oct. 19 , 2017 Sheet 3 of 4 US 2017 /0296568 A1 Hun passumusu . WAMAMAAN carjoune Barley TulogRagnar ile paras Girigente BeteblossomHoa Oliver AlleerS02 as die ***Möjao post me iemRaspberry lealSummary out ????????? canaliAnguia * pokusana(:Orinenat www . Barondes per le * cisternomne Vietnam * LENO * madaraqueuzeoLapsussaisi .extraet leaf youtup stareut Oliva wwwwwwwwwwwwwwwwwwwwwwwww wwwwwwwwwwww Escrignaunana na www Stogonopapuzio maana * ** Kako nad Megan Fig3 Patent Application Publication Oct . 19 , 2017 Sheet 4 of 4 US 2017 /0296568 A1 )CTResveratro (DMSO 17* FF} 1.5 ???? [ 4] * . Sedamot .w . miastamini Sesamolinimesas 2 4 4 * 90319599spisoon . * + P991episcona * - - - WIZKAIADAO - - LlaluLipuydea - PalmitateKaluweel - .CafestolPalmitate Cafdstel LOSTFisctin SaponariodeTiliros acidRosmarinsic 1-B Oinamtaninin )ATellimagrandinUrošlthen - uwepo+ urd - - wwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwww fal - acidElmo - - - Echinacquisto - ?$ opeast - wwwwwwwwwwwwww - 1950 ??????? POSOAKARO.PH 103 pie4 US 2017 /0296568 A1 Oct . 19, 2017 SIRTUIN GENE POTENTIATOR , AND Means for Solving the Problems PHARMACEUTICAL PRODUCT, COSMETIC [0008 ] The present invention provides a sirtuin gene PRODUCT, AND FOOD PRODUCT USING potentiator including a polyphenol as an active component. SAME The polyphenol is at least one compound selected from the group consisting of punicalin , punicalagin , urolithin A , CROSS -REFERENCE TO RELATED eugeniin , tellimagrandin I , and an analog thereof. APPLICATION [ 0009 ] The present invention also provides a sirtuin gene potentiator including a terpenoid as an active component. [ 0001 ] The present application is continuation claiming The terpenoid is at least one compound selected from the benefit and priority under 35 U . S . C . $ 120 of U . S . application group consisting of cafestol, kahweol, glycyrrhizin , and an Ser. No. 14 / 427, 312 , filed 11 Mar. 2015 , now , which is a analog thereof. U . S . National Stage Application under 35 USC $ 371 of [0010 ] In one embodiment, the polyphenol is contained in International Application No . PCT/ JP2013 /074939 , filed 13 the form of a plant or a plant extract. Sep . 2013, published as WO 2014 /042261 A1 on 20 Mar. [0011 ] In a further embodiment, the plant or the plant 2014 , which in turn claims priority to Japanese Application extract is pomegranate or a pomegranate extract . No . 2012 - 201899 , filed 13 Sep . 2012 , the entirety of each of [0012 ] In another embodiment, the terpenoid is contained which are incorporated herein by reference. in the form of a plant or a plant extract . 10013 ] The present invention further provides a pharma TECHNICAL FIELD ceutical composition , comprising the sirtuin gene potentia [ 0002 ] The present invention relates to a sirtuin gene tor. potentiator, and a pharmaceutical product , a cosmetic prod [0014 ] The present invention further provides a cosmetic uct , and a food product using the same, and more specifically composition , comprising the sirtuin gene potentiator. relates to a sirtuin gene potentiator as easily available and [0015 ] The present invention further provides a food com with little concerns to cause side effects on the human body, position , comprising an isolated polyphenol and / or terpe and a pharmaceutical product , a cosmetic product , and a noid , wherein the polyphenol is at least one compound food product using the same. selected from the group consisting of punicalin , punicalagin , urolithin A , eugeniin , tellimagrandin I , and an analog BACKGROUND ART thereof, and the terpenoid is at least one compound selected [ 0003] In studies of aging and lifetime control, the from the group consisting of cafestol, kahweol, glycyrrhizin , involvement of Sirtuin , Sir2 , which has the activity of an and an analog thereof . NAD - dependent deacetylase , has been attracting attention . SIRTs 1 to 7 are known as mammalian homologs of yeast Effects of Invention Sir2 . In particular, SIRT1 has been considered to be involved in the control of enhancement of fat mobilization , suppres [0016 ] According to the present invention , a functional sion of nerve axonal degeneration , insulin secretion from B material capable of enhancing the activity of the sirtuin gene cells , gluconeogenesis in the liver , and the like, and to as considered to be involved in life prolongation and anti realize life prolongation through the control. aging can be easily provided in large amounts . The sirtuin [ 0004 ] It has been attracting attention that a substance gene potentiator of the present invention is available from a available from a familiar material is used for enhancing the familiar material to previously avoid concerns such as side activity of the sirtuin gene so as to provide a life prolonga effects on the human body. tion effect for mammals . Examples of the material include a lactic acid bacterium and a component derived from a lactic BRIEF DESCRIPTION OF DRAWINGS acid bacterium (Patent Document 1 ) . 0005 ] However, a few types of substances capable of [ 0017 ] FIG . 1 is a graph showing the effect on the hSIRT1 enhancing the activity of such sirtuin gene and available promoter activity when various polyphenols or terpenoids from a familiar material have been found , and , furthermore , are added to Caco - 2 -hSIRT1p - EGFP cells . it is hard to say that there is a sufficient number of types of [0018 ] FIG . 2 is a graph showing the expression level of substances having an excellent activity . the sirtuin gene hSIRT1 in Caco - 2 cells after various poly phenols or terpenoids are added . PRIOR ART DOCUMENTS [0019 ] FIG . 3 is a graph showing the effect on the hSIRT1 promoter activity when various plants or plant extracts are added to Caco - 2 - hSIRT1p - EGFP cells . Patent Documents [0020 ] FIG . 4 is a graph showing the EGFP fluorescence [0006 ] Patent Document 1 : Japanese Laid - Open Patent intensity in HaCaT -HSIRT1p - EGFP cells after various poly Publication No. 2008 - 195673 phenols or terpenoids are added . SUMMARY OF INVENTION MODE FOR CARRYING OUT THE INVENTION [ 0021 ] Hereinafter , the present invention will be described Problems to be Solved by the Invention in detail . 10007 ] The present invention solves the above - described [0022 ] A sirtuin gene potentiator according to the present problems, and it is an object thereof to provide a sirtuin gene invention contains a plant and / or a plant- derived component potentiator, which is available from a familiar material and as an active component . has an excellent enhancing activity , and a pharmaceutical [0023 ] The term
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    CALIFORNIA WALNUT COMMISSION PUBLISHED HEALTH RESEARCH ABSTRACTS OF PUBLICATIONS APRIL 2020 The California Walnut Commission (CWC) has supported health research on walnuts for more than 25 years. The CWC is committed to building a strong foundation of scientific evidence that reveals the health effects of walnut consumption. Current areas of study include heart health, cognitive health, cancer, diabetes, body weight and composition, gut health and reproductive health. The CWC provides funding and/or walnuts for peer-reviewed projects. These studies are conducted independently by the researchers who design, analyze, interpret and prepare manuscripts. California Walnut Commission Supported Publications Key Area Summary: 175 publications Heart Health: 51 Diabetes: 11 Reproductive Health: 4 Cancer: 32 Nutrient & Bioactive Composition: 6 Gut Health: 3 Body Weight and Composition: 32 Research Methodology: 5 Bone Health: 1 Cognitive Health: 25 Metabolic Syndrome: 5 Number of Publications Per Year 2020: 8 2019: 20 2014: 19 2009: 10 2004: 3 2018: 21 2013: 7 2008: 3 2002: 2 2017: 20 2012: 11 2007: 3 2001: 3 2016: 16 2011: 5 2006: 2 2000: 1 2015: 8 2010: 8 2005: 4 1993: 1 All abstracts from http://www.ncbi.nlm.nih.gov/pubmed 2020 Al Abdrabalnabi A, Rajaram S, Bitok E, Oda K, Beeson WL, Kaur A, Cofán M, Serra-Mir M, Roth I, Ros E, Sabaté J. Effects of Supplementing the Usual Diet with a Daily Dose of Walnuts for Two Years on Metabolic Syndrome and Its Components in an Elderly Cohort. Nutrients. 2020 Feb 11;12(2). pii: E451. doi: 10.3390/nu12020451. Abstract: Accumulating evidence links nut consumption with an improved risk of metabolic syndrome (MetS); however, long-term trials are lacking.
  • Compositions and Methods for Improving

    Compositions and Methods for Improving

    (19) TZZ¥ ZZ_T (11) EP 3 278 800 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 31/352 (2006.01) A61K 36/00 (2006.01) 10.04.2019 Bulletin 2019/15 A61K 36/185 (2006.01) (21) Application number: 17186188.3 (22) Date of filing: 23.12.2011 (54) COMPOSITIONS AND METHODS FOR IMPROVING MITOCHONDRIAL FUNCTION AND TREATING MUSCLE-RELATED PATHOLOGICAL CONDITIONS ZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERBESSERUNG DER MITOCHONDRIENFUNKTION UND BEHANDLUNG VON PATHOLOGISCHEN MUSKULÄREN ERKRANKUNGEN COMPOSITIONS ET PROCÉDÉS POUR AMÉLIORER LA FONCTION MITOCHONDRIALE ET TRAITER DES CONDITIONS PATHOLOGIQUES MUSCULAIRES (84) Designated Contracting States: • PIRINEN, Eija AL AT BE BG CH CY CZ DE DK EE ES FI FR GB 00240 Helsinki (FI) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO •THOMAS,Charles PL PT RO RS SE SI SK SM TR 21000 Dijon (FR) • HOUTKOOPER, Richardus (30) Priority: 23.12.2010 US 201061426957 P Weesp (NL) • BLANCO-BOSE, William (43) Date of publication of application: CH-1090 La Croix (Lutry) (CH) 07.02.2018 Bulletin 2018/06 • MOUCHIROUD, Laurent 1110 Morges (CH) (60) Divisional application: • GENOUX, David 18166896.3 / 3 372 228 CH-1000 Lausanne (CH) 18166897.1 / 3 369 420 (74) Representative: Abel & Imray (62) Document number(s) of the earlier application(s) in Westpoint Building accordance with Art. 76 EPC: James Street West 11808119.9 / 2 654 461 Bath BA1 2DA (GB) (73) Proprietor: Amazentis SA (56) References cited: 1015 Lausanne (CH) US-A1- 2003 078 212 US-A1- 2009 326 057 (72) Inventors: • JUSTIN R.
  • Traditional Applications of Tannin Rich Extracts Supported by Scientific Data: Chemical Composition, Bioavailability and Bioaccessibility

    Traditional Applications of Tannin Rich Extracts Supported by Scientific Data: Chemical Composition, Bioavailability and Bioaccessibility

    foods Review Traditional Applications of Tannin Rich Extracts Supported by Scientific Data: Chemical Composition, Bioavailability and Bioaccessibility Maria Fraga-Corral 1,2 , Paz Otero 1,3 , Lucia Cassani 1,4 , Javier Echave 1 , Paula Garcia-Oliveira 1,2 , Maria Carpena 1 , Franklin Chamorro 1, Catarina Lourenço-Lopes 1, Miguel A. Prieto 1,* and Jesus Simal-Gandara 1,* 1 Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, Ourense Campus, University of Vigo, 32004 Ourense, Spain; [email protected] (M.F.-C.); [email protected] (P.O.); [email protected] (L.C.); [email protected] (J.E.); [email protected] (P.G.-O.); [email protected] (M.C.); [email protected] (F.C.); [email protected] (C.L.-L.) 2 Centro de Investigação de Montanha (CIMO), Campus de Santa Apolonia, Instituto Politécnico de Bragança, 5300-253 Bragança, Portugal 3 Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain 4 Research Group of Food Engineering, Faculty of Engineering, National University of Mar del Plata, Mar del Plata RA7600, Argentina * Correspondence: [email protected] (M.A.P.); [email protected] (J.S.-G.) Abstract: Tannins are polyphenolic compounds historically utilized in textile and adhesive industries, Citation: Fraga-Corral, M.; Otero, P.; but also in traditional human and animal medicines or foodstuffs. Since 20th-century, advances in Cassani, L.; Echave, J.; analytical chemistry have allowed disclosure of the chemical nature of these molecules. The chemical Garcia-Oliveira, P.; Carpena, M.; profile of extracts obtained from previously selected species was investigated to try to establish a Chamorro, F.; Lourenço-Lopes, C.; bridge between traditional background and scientific data.