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Us 2017 / 0296568 A1 US 20170296568A1 ( 19) United States (12 ) Patent Application Publication (10 ) Pub. No. : US 2017/ 0296568 A1 KATAKURA et al. (43 ) Pub . Date : Oct. 19 , 2017 ( 54 ) SIRTUIN GENE POTENTIATOR , AND Publication Classification PHARMACEUTICAL PRODUCT, COSMETIC (51 ) Int . Ci. PRODUCT, AND FOOD PRODUCT USING A61K 31 / 7048 (2006 . 01 ) SAME A61K 8 / 97 ( 2006 .01 ) A61K 8 /60 ( 2006 .01 ) (71 ) Applicants :MORISHITA JINTAN CO . , LTD . , A61K 36 / 185 ( 2006 . 01 ) Osaka ( JP ) ; KYUSHU UNIVERSITY , A23L 33/ 105 ( 2006 .01 ) NATIONAL UNIVERSITY A61Q 19 /00 ( 2006 .01 ) CORPORATION , Fukuoka ( JP ) A23L 2 / 52 (2006 . 01) ( 52 ) U . S . CI. (72 ) Inventors: Yoshinori KATAKURA , Fukuoka ( JP ) ; CPC . .. A61K 31 / 7048 ( 2013 . 01 ) ; A610 19 / 007 Takeru SUYAMA , Osaka ( JP ) ; ( 2013 . 01 ) ; A61K 8 / 97 ( 2013 .01 ) ; A23L 2 / 52 Norihisa NISHIDA , Osaka ( JP ) (2013 .01 ) ; A61K 36 / 185 (2013 .01 ) ; A23L 33 / 105 (2016 .08 ) ; A61K 8 /60 ( 2013 . 01 ) ; A23V 2002 /00 ( 2013 .01 ) ; A61K 2800 /78 (2013 .01 ) ( 21 ) Appl. No. : 15 /628 ,684 ( 57 ) ABSTRACT Disclosed are a method for potentiating a sirtuin gene in a living body , provided to the living body as a pharmaceutical (22 ) Filed: Jun . 21, 2017 product, a cosmetic product, or a food product including a sirtuin gene potentiator. The sirtuin gene potentiator of the present invention contains a given polyphenol and /or terpe Related U . S . Application Data noid as an active component. The polyphenol and / or the (63 ) Continuation of application No. 14 /427 , 312 , filed on terpenoid can be contained in the form of a plant such as Mar. 11, 2015 , filed as application No . PCT / JP2013 / pomegranate or a plant extract thereof. The sirtuin gene 074939 on Sep . 13 , 2013 . potentiator of the present invention is available from a familiar material to avoid concerns such as side effects on ( 30) Foreign Application Priority Data the human body in advance. Such a sirtuin gene potentiator is useful as a novel material in the fields of pharmaceutical Sep . 13, 2012 ( JP ) .. .. 2012 - 201899 products , cosmetic products , and food products . Patent Application Publication Oct. 19 , 2017 Sheet 1 of 4 US 2017 /0296568 A1 ulash viele eebel Batarde wwwwwwww * * * * trai * v w * Glycynicin * * * palmitateKaltweol KatiwapalmitateCélestal * Caiete Ostunicillidalatin wwwwwwwwwwww very ???? wwwwwwwwwvvwvww* % w vvvvvv * v TilasideSkrelarina acidRosmarinic wwwww 1Bugenin:5Onnaintarinin wmanvivvvvvvvvvvvvvve w 1Telliminerendia N* * UDAPogle Wwwww Polin . Casild * *wwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwww * StadtbanedeScitatacasele * 1 TrosalActeonide * Hydroxyturosal?????? minutos 88 136 os socok syHHHHHHHHHHHHHHH w Patent Application Publication Oct. 19 , 2017 Sheet 2 of 4 US 2017 /0296568 A1 w FZLUQUOCO jame Cafestol coracocerceariMAA Fisetin . Eugenin V on www wwwwwwwwwwwww Punicatogin At1 * * Mm mm Resveratrol sa Uritreated Bigy 10 janez votesbloxo SUIQ papujen Fig.2 Patent Application Publication Oct. 19 , 2017 Sheet 3 of 4 US 2017 /0296568 A1 Hun passumusu . WAMAMAAN carjoune Barley TulogRagnar ile paras Girigente BeteblossomHoa Oliver AlleerS02 as die ***Möjao post me iemRaspberry lealSummary out ????????? canaliAnguia * pokusana(:Orinenat www . Barondes per le * cisternomne Vietnam * LENO * madaraqueuzeoLapsussaisi .extraet leaf youtup stareut Oliva wwwwwwwwwwwwwwwwwwwwwwwww wwwwwwwwwwww Escrignaunana na www Stogonopapuzio maana * ** Kako nad Megan Fig3 Patent Application Publication Oct . 19 , 2017 Sheet 4 of 4 US 2017 /0296568 A1 )CTResveratro (DMSO 17* FF} 1.5 ???? [ 4] * . Sedamot .w . miastamini Sesamolinimesas 2 4 4 * 90319599spisoon . * + P991episcona * - - - WIZKAIADAO - - LlaluLipuydea - PalmitateKaluweel - .CafestolPalmitate Cafdstel LOSTFisctin SaponariodeTiliros acidRosmarinsic 1-B Oinamtaninin )ATellimagrandinUrošlthen - uwepo+ urd - - wwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwwww fal - acidElmo - - - Echinacquisto - ?$ opeast - wwwwwwwwwwwwww - 1950 ??????? POSOAKARO.PH 103 pie4 US 2017 /0296568 A1 Oct . 19, 2017 SIRTUIN GENE POTENTIATOR , AND Means for Solving the Problems PHARMACEUTICAL PRODUCT, COSMETIC [0008 ] The present invention provides a sirtuin gene PRODUCT, AND FOOD PRODUCT USING potentiator including a polyphenol as an active component. SAME The polyphenol is at least one compound selected from the group consisting of punicalin , punicalagin , urolithin A , CROSS -REFERENCE TO RELATED eugeniin , tellimagrandin I , and an analog thereof. APPLICATION [ 0009 ] The present invention also provides a sirtuin gene potentiator including a terpenoid as an active component. [ 0001 ] The present application is continuation claiming The terpenoid is at least one compound selected from the benefit and priority under 35 U . S . C . $ 120 of U . S . application group consisting of cafestol, kahweol, glycyrrhizin , and an Ser. No. 14 / 427, 312 , filed 11 Mar. 2015 , now , which is a analog thereof. U . S . National Stage Application under 35 USC $ 371 of [0010 ] In one embodiment, the polyphenol is contained in International Application No . PCT/ JP2013 /074939 , filed 13 the form of a plant or a plant extract. Sep . 2013, published as WO 2014 /042261 A1 on 20 Mar. [0011 ] In a further embodiment, the plant or the plant 2014 , which in turn claims priority to Japanese Application extract is pomegranate or a pomegranate extract . No . 2012 - 201899 , filed 13 Sep . 2012 , the entirety of each of [0012 ] In another embodiment, the terpenoid is contained which are incorporated herein by reference. in the form of a plant or a plant extract . 10013 ] The present invention further provides a pharma TECHNICAL FIELD ceutical composition , comprising the sirtuin gene potentia [ 0002 ] The present invention relates to a sirtuin gene tor. potentiator, and a pharmaceutical product , a cosmetic prod [0014 ] The present invention further provides a cosmetic uct , and a food product using the same, and more specifically composition , comprising the sirtuin gene potentiator. relates to a sirtuin gene potentiator as easily available and [0015 ] The present invention further provides a food com with little concerns to cause side effects on the human body, position , comprising an isolated polyphenol and / or terpe and a pharmaceutical product , a cosmetic product , and a noid , wherein the polyphenol is at least one compound food product using the same. selected from the group consisting of punicalin , punicalagin , urolithin A , eugeniin , tellimagrandin I , and an analog BACKGROUND ART thereof, and the terpenoid is at least one compound selected [ 0003] In studies of aging and lifetime control, the from the group consisting of cafestol, kahweol, glycyrrhizin , involvement of Sirtuin , Sir2 , which has the activity of an and an analog thereof . NAD - dependent deacetylase , has been attracting attention . SIRTs 1 to 7 are known as mammalian homologs of yeast Effects of Invention Sir2 . In particular, SIRT1 has been considered to be involved in the control of enhancement of fat mobilization , suppres [0016 ] According to the present invention , a functional sion of nerve axonal degeneration , insulin secretion from B material capable of enhancing the activity of the sirtuin gene cells , gluconeogenesis in the liver , and the like, and to as considered to be involved in life prolongation and anti realize life prolongation through the control. aging can be easily provided in large amounts . The sirtuin [ 0004 ] It has been attracting attention that a substance gene potentiator of the present invention is available from a available from a familiar material is used for enhancing the familiar material to previously avoid concerns such as side activity of the sirtuin gene so as to provide a life prolonga effects on the human body. tion effect for mammals . Examples of the material include a lactic acid bacterium and a component derived from a lactic BRIEF DESCRIPTION OF DRAWINGS acid bacterium (Patent Document 1 ) . 0005 ] However, a few types of substances capable of [ 0017 ] FIG . 1 is a graph showing the effect on the hSIRT1 enhancing the activity of such sirtuin gene and available promoter activity when various polyphenols or terpenoids from a familiar material have been found , and , furthermore , are added to Caco - 2 -hSIRT1p - EGFP cells . it is hard to say that there is a sufficient number of types of [0018 ] FIG . 2 is a graph showing the expression level of substances having an excellent activity . the sirtuin gene hSIRT1 in Caco - 2 cells after various poly phenols or terpenoids are added . PRIOR ART DOCUMENTS [0019 ] FIG . 3 is a graph showing the effect on the hSIRT1 promoter activity when various plants or plant extracts are added to Caco - 2 - hSIRT1p - EGFP cells . Patent Documents [0020 ] FIG . 4 is a graph showing the EGFP fluorescence [0006 ] Patent Document 1 : Japanese Laid - Open Patent intensity in HaCaT -HSIRT1p - EGFP cells after various poly Publication No. 2008 - 195673 phenols or terpenoids are added . SUMMARY OF INVENTION MODE FOR CARRYING OUT THE INVENTION [ 0021 ] Hereinafter , the present invention will be described Problems to be Solved by the Invention in detail . 10007 ] The present invention solves the above - described [0022 ] A sirtuin gene potentiator according to the present problems, and it is an object thereof to provide a sirtuin gene invention contains a plant and / or a plant- derived component potentiator, which is available from a familiar material and as an active component . has an excellent enhancing activity , and a pharmaceutical [0023 ] The term
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