Endometriosis and Women's Reproductive Life

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1ST CONGRESS OF THE SOCIETY OF ENDOMETRIOSIS AND UTERINE DISORDERS

Endometriosis and women’s reproductive life 2015 MAY 7-8-9

Location Congress President Paris, France Pr Charles Chapron, Paris, France Marriott Rive Gauche Table of contents

4 WELCOME NOTE

5 BOARDS / FACULTIES AND INTERNATIONAL COMMITTEE

6 PROGRAM

24 SOCIAL PROGRAM

26 PARIS, A FABULOUS HERITAGE

28 PARTNERS

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Dear friends and colleagues, CONGRESS PRESIDENT : ORGANIZING COMMITTEE Charles Chapron, France Bruno Borghese, On behalf of the scientific board and the organizing committee, I am honored to wel- Vanessa Gayet come you in Paris for the first congress of the “Society of Endometriosis and Uterine Arnaud Le Tohic, Disorders” (SEUD). Louis Marcellin, Pierre Panel, The aim of SEUD is to offer an international scientific platform for giving the possibility Pietro Santulli, to have a comprehensive approach of womens’ health in the field of benign gynecolo- Dominique de Ziegler gical diseases related to uterine dysfunctions. The objective of the SEUD is to focus the attention on a group of benign gynecological diseases which affect womens’ health (endometriosis, adenomyosis, uterine fibroids, polyps, heavy menstrual bleeeding, uterine malformations and others). Faculties and

The congress has been designed to provide an innovative and comprehensive overview of the latest research developments in endometriosis, in uterine disorders and in wo- international committee men’s reproductive life fields. A F P Many distinguished scientists from all over the world take part to this congress. I would Mauricio Abrao, Brazil Jacques Faidherbe, France Pierre Panel, France like to sincerely thank them for their investment. Moamar Al-Jefout, Jordan Arnaud Fauconnier, France Antonio Pellicer, Spain B Hervé Fernandez, France Felice Petraglia, Italy The steering Committee hopes this meeting will provide an exceptional opportunity for Frédéric Batteux, France Yoke Fai Fong, Singapore Carlos Petta, Brazil you to share your expertise in order to develop and Jean-Louis Benifla, France Hervé Foulot, France George Pistofidis, Greece facilitate ongoing collaborations and studies. Stefano Bettocchi, Italy G Alexander Popov, Russia The congress will be articulated around plenary ses- Bruno Borghese, France Juan Garcia-Velasco, Spain Jean-Luc Pouly, France sions, conferences, debates, KOL positions, sympo- Antoine Bourret, France Vanessa Gayet, France Gérard Priou, France sia, live surgery… Moreover free communications, Ivo Brosens, Belgium François Golfier, France R posters and videos assure this meeting will know a Serdar E. Bulun, USA Sun-Wei Guo, China Fernando Reis, Brazil resounding success. C H Horace Roman, France I am honored to Michel Canis, France Tasuku Harada, Japan Bo R. Rueda, USA We hope that you will enjoy the congress and that Francisco Carmona, Spain Oskari Heikinheimo, Finland S your interaction with your colleagues from different welcome you all in Charles Chapron, France Thomas d’Hooghe, Belgium Pietro Santulli, France countries will stimulate a creative exchange of ideas Jung-Hye Choi, Korea K Gamal Serour, Egypt and will be personally rewarding. We also hope and Pasquapina Ciarmela, Italy Joerg Keckstein, Austria Edgardo Somigliana, Italy trust that you will enjoy your visit to the very beautiful Paris for the first SEUD and exciting city of Paris. Justin Clark, UK Rosanne M. Kho, USA Isabelle Streuli, Switzerland congress. Pierre Collinet, France L T Yours sincerely Hilary Critchley, UK Philippe Y. Laberge, Canada Hugh S. Taylor, USA C. Chapron D Marie Christine Lafay-Pillet, France Jim Tsaltas, Australia Philippe Descamps, France Arnaud Le Tohic, France V Professor Charles Chapron, Paul Devroey, Belgium M Daniel Vaiman, France 1st SEUD Congress President Pierre-Hervé Dorangeon, France Maguette Mbaye, Senegal Sebastiaan Veersema, The Netherlands Paris, France Bertrand Dousset, France Louis Marcellin, France Valérie Vernaeve, Spain E Anne-Elodie Millischer, France Z Jean-Philippe Estrade, France Michael Mueller, Switzerland Dominique de Ziegler, France N Errico Zupi, Italy Julien Niro, France

4 5 PROGRAM Program at a glance

TIONS SYMPOSIUM COMMUNICA FREE NORDIC PHARMA

TIONS COMMUNICA FREE VIDEO SESSION VIDEO SESSION VIDEO

VISI T 9TH OF MA S

TIONS TIONS COMMUNICA FREE TIONS COMMUNICA FREE AY COMMUNICA FREE ARDS CEREMONY

FORUM

TIONS TIONS COMMUNICA FREE TIONS COMMUNICA FREE FREE COMMUNICA FREE VISI T COFFEE BREAK AND TURD AND EXHIBITION A AIL LUNCH : I TE LECTURE AND ENDOMETRIOSI CLOSING COCKT AND KEYNO AND EXIBITION ANCES FORUM

UTERINE FIBROIDS ADV FUTURE IN RESEARCH EPIGENETICS TIENTS SESSION KOL POSITIONS ENDOMETRIOSIS PA

H TIONS COMMUNICA FREE

YS TIONS AL COMMUNICA FREE

TIONS TE COMMUNICA FREE

FORUM TIONS FREE COMMUNICA FREE ACET MEDICAL Y USSIAN SESSION VISI T WITH ULIPRIST AND CARE MANAGEMENT OF R UTERINE FIBROIDS TIVE A G AN UNMET NEED – S

G VISI T ASSEMBL 8TH OF MA ANDING CAUSES AND AND TMENT TO INNOV AY DEEP VI C TION, AND LIVE SCAN FORUM TE LECTURE AND EXHIBITION TREA

PEL S SESSION SESSION FIBROIDS VISI T AIN COURSE UNDERST AILLEURS - ELSEWHERE ELSEWHERE FRANCE SCGP / SEUD SCGP / SEUD P OCIAL EVENI N AILLEURS - IN EN FRANCE ET EN FRANCE ET COFFEE BREAK IN FRANCE SYMPOSIUM ON S ENDOMETRIOSI ENDOMETRIOSIS FROM FRID UGS FOR CANADIAN SESSION KEYNO DIAGNOSIS SEUD GENERAL AND EXHIBITION

AIL LUNCH Y TE LECTURE C S

COFFEE BREAK ENDOMETRIOSI TILITY COCKT KEYNO FUTURE DR IMAGING SURGER AND EXHIBITION : : CURRENT CLASSIFICA KOL TE FORUM TE ABNORMAL UTERINE BLEEDING –

FOR DEEP POSITIONS DISORDERS AND UTERINE ADENOMYOSI ENDOMETRIOSIS ENDOMETRIOSI AND INFER DEBA DEBA FOR ENDOMETRIOSIS

B ®

Y s

Visanne

in the ® FORUM IN E

W W

bleeding targets in ND endometriosi Mirena New insights to A A management of

heavy menstrual and new research Current and future : perspectives: SE N A : O 7TH OF MA VISI T VISI T CHEE

EPTI &

C S& S AY AIL LUNCH FORUM

TION ME RE A COFFEE BREA STEROIDS, CO ENT COCKT IPSEN SYMPOSIUM OPENING CEREMONY AND EXHIBITION AND EXHIBITION WEL WELCOME DESK OPENING PRES TE LECTURE

THURSD AND UTERINE FIBROIDS S Y ERS KEYNO STEMS CELLS, DANGEROUS LIAISONS POST LIFE AND UTERINE SESSION DNA, BLEEDING ABNORMAL LIVE SURGER REPRODUCTIVE ENDOMETRIOSI SCÈNE C ENDOMETRIOSIS

7.30 > 8.00 > 8.30 > 9.00 > 9.30 > 10.00 > 10.30 > 11.00 > 11.30 > 12.00 > 12.30 > 13.00 > 13.30 > 14.00 > 14.30 > 15.00 > 15.30 > 16.00 > 16.30 > 17.00 > 17.30 > 18.00 > 18.30 > 19.00 > 19.30 > 20.00 > 20.30 > 21.00 > SCÈNE B

7 8 Program 14.30 Scène B & C Room - Plenary session Opening ceremony Chair : Charles Chapron (France) - Co Chair : Felice Petraglia (Italy)

14.45 Scène B & C Room - Plenary session THURSDAY 7TH OF MAY 16.15 Endometriosis and reproductive life Chair : Yoke Fai Fong (Singapore) - Co Chair : Jim Tsaltas (Australia) 7.45 Welcome desk opening , Fetal roots of endometriosis, Ivo Brosens (Belgium) , Is adolescence a crucial period for endometriosis patients ? Thomas d’Hooghe (Belgium) 08.30 Scène C Room , Perimenopausal endometriosis, Fernando Reis (Brazil) 12.00 Live surgery session from Versailles Hospital and Rouen Hospital , Endometriosis and quality of life, Pistofidis George (Greece) Chair : Bruno Borghese (France) - Co Chairs : Alexander Popov (Russia)), Emmanuel Bailly (France) Discussion Chair : Moamar Al Jefout (Jordan) - Co Chairs : Hervé Foulot (France), Emmanuel Bailly (France) , 16.15 Coffee break and exhibition visit 09.45 Scène B Room 11.45 Current and future perspectives : Visanne® and new research targets 16.45 Scène B & C Room - Plenary session in endometriosis 18.15 Abnormal uterine bleeding , Welcome and introduction, Carlos Petta (Brazil) Chair : Carlos Petta (Brazil) - Co Chair : Maguette Mbaye (Senegal) , Why approach endometriosis as an inflammatory disease ? Pietro Santulli (France) , AUB management : how do systematic reviews and meta-analysis help ? Justin Clark (UK) The mechanism(s) of LNG-IUS action in the heavy menstrual bleeding treatment, , Tailoring endometriosis treatment: medical and surgical options, Renato Seracchioli (Italy) , Oskari Heikinheimo (Finland) ® Endometrial ablation : past, present and future, , Evidence-based management of endometriosis with Visanne , Andreas D. Ebert (Germany) , Philippe Y. Laberge (Canada) AUB and pelvic pain : specific management, ) , How can we best manage our patients for the long term ? Sony S. Singh (Canada) , Errico Zupi (Italy Discussion , Bayer’s future medical treatment options, Thomas M. Zollner (Germany) , , Q&A, summary, own experience and close, Carlos Petta (Brazil) 18.15 Scène B & C Room - Keynote lecture 18.45 12.15 Scène B Room DNA, stems cells, steroids, endometriosis and uterine fibroids : 13.45 New insights to Mirena® in the management of heavy menstrual bleeding dangerous liaisons Chair : Hervé Fernandez (France) Serdar E. Bulun (USA) , The global burden of HMB, Joaquin Calaf (Spain) Chair : Felice Petraglia (Italy) How does Mirena® compare to other treatments for HMB ? , Marc-Yvon Arsenault (Canada) 18.45 Welcome reception : Posters presentations & cheese and wine , Mirena® in the management of HMB in special patient groups, Oskari Heikinheimo (Finland) Original 12.15 Scène C Room 13.15 Endometriosis: taking into account the patient’s perspective for better care? Chair : Arnaud Fauconnier (France) , Toward early diagnosis, what would be the best strategy ? Jin Hua Leng (China) , Socio-cultural differences in identifying and treating endometriosis : results of the international FEELINGFind study, from PDF recreate PMS Charles Chapron (France) , LHRHa in the treatment of endometriosis : what are patients expectancies and fears ? Alexander Popov (Russia) 13.45 Cocktail lunch and exhibition visit

9 10 Program 11.00 Scène B & C Room - Plenary session 12.30 Adenomyosis Chair : Jung-Hye Choi (Korea) - Co Chair : Gamal Serour (Egypt) , Cracking the enigma of adenomyosis, Sun-Wei Guo (China) FRIDAY 8TH OF MAY , Diffuse and focal adenomyosis : one or two distinct entities ? Charles Chapron (France) , How adenomyosis causes infertility ? Tasuku Harada (Japan) Modern management of adenomyosis, 07.45 Forum A-B-C Room - Satellite Session , Alexander Popov (Russia) 09.00 Pelvic pain course , Discussion Chair : Errico Zupi (Italy) - Co Chair : Gérard Priou (France) 11.00 Forum A-B-C Room - Satellite Session , Pathogenesis of endometriosis – related pelvic pain. Mauricio Abrao (Brazil) 12.30 Canadian session : Symposium on fibroids and endometriosis ,, Endometriosis : how to evaluate the pain ? Arnaud Fauconnier (France) Chair : Philippe Y. Laberge (Canada) , Optimization of medical management for pain in endometriosis. Jacques Faidherbe (France) , Fibroids management : the new canadian guidelines. Nick Leyland (Canada) , Circumstances of deep endometriosis surgery that can affect pelvic pain sub optimally. George Pistofidis (Greece) , Endometriosis - related pain : an integrated approach. Catherine. Allaire (Canada) Laparoscopic morcellation : the new paradigm in endoscopic surgery. John Thiel (Canada) 09.00 Scène B & C Room - Plenary session , 10.30 , Hysteroscopy and myoma : monopolar, bipolar or mechanical aspiration ? Claude Fortin (Canada) Endometriosis and infertility (Ferring sponsored session) Chair : Paul Devroey (Belgium) - Co Chair : Edgardo Somigliana (Italy) 12.30 Scène B & C Room - Keynote lecture , Clinical utility of AMH in endometriotic patients, Isabelle Streuli (Switzerland) 13.00 Future drugs for endometriosis ,, Endometrial receptivity and ART outcomes ? Antonio Pellicer (Spain) Felice Petraglia (Italy) , ART : is the differed embryo transfer a new strategic option ? Pietro Santulli (France) Chair : Frédéric Batteux (France) , What is the real place of surgery for infertile patients with endometriosis ? Jim Tsaltas (Australia) , Discussion 13.00 Scène B & C Room 14.30 Medical Management of Uterine Fibroids with Ulipristal Acetate 09.00 Forum A-B-C Room - Satellite Session Chair : Hervé Fernandez (France) 10.30 Session SCGP / SEUD - En France et ailleurs - In France and elsewhere , Mode of action and application of SPRMs in the treatment of uterine fibroids,Nathalie Chabbert Buffet (France) Let’s compare French and international positioning ! (French and English speaking session) , Efficacy and safety of Ulipristal Acetate : clinical evidence from Pearl I, II & III trials, Hans Tinneberg (Germany) Chair : Jean-Philippe Estrade (France) - Co Chair : Philippe Y. Laberge (Canada) , Real-world data on Ulipristal Acetate treatment : an update on the PREMYA study, Hervé Fernandez (France) , Thermodestruction endométriale, Jean-Louis Benifla (France) , Repeated intermittent use of Ulipristal Acetate : new phase III data from the Pearl IV part 1 trial, Ernest Loumaye (Belgium) Endometrial thermablation, Philippe Y. Laberge (Canada) , Discussion ,, Chirurgie coelioscopique : 2D, 3D ou robot ? Pierre Collinet (France) Laparoscopic surgery : 2D, 3D or robotic ? Rosanne M. Kho (USA) 13.00 Cocktail lunch and exhibition visit , Stérilisation féminine, Pierre Panel (France) 14.30 Scène B & C Rooms - Plenary session Female sterilization, Sebastiaan Veersema (The Netherlands) 14.45 SEUD General assembly 10.30 Coffee break and exhibition visit

11 12 Program Free communication 2 - Endometriosis Clinical - Forum H Room - Chair : Marie-Christine Lafay-Pillet (France) , The risk of urinary retention after nerve-sparing surgery for deep infiltrating endometriosis : a systematic review and meta-analysis, Marlon De Freitas-Fonseca (Brazil) , Laparoscopic neurolisys for deep endometriosis infiltrating pelvic wall and somatic nerves : a retrospective study on 216 patients, FRIDAY 8TH OF MAY Marcello Ceccaroni (Italy) , Predictive value of endometriosis fertility index (EFI) for natural pregnancy rate after laparoscopy treatment in chinese women with endometriosis-associated infertility, Xianghui Zhang (China) Real-Time virtual sonography using MRI-US fusion imaging for the evaluation of deep infiltrating endometriosis : feasibility and 14.45 Scène B & C Room - Plenary session , preliminary results, Anne-Elodie Millischer (France) 16.45 KOL positions Chair : Bo R. Rueda (USA) - Co Chair : Pierre-Hervé Dorangeon (France) , Long-time effects of mindfulness-based psychological treatment on chronic pain and quality of life in endometriosis, Karina-Ejgaard Hansen (Denmark) , Is endometriosis a precancerous disease ? Jung-Hye Choi (Korea) Ureteral endometriosis associated with hydronephrosis, Maria-Angeles Martinez-Zamora (Spain) , AUB : clinical problems and desire of patients : how to decide ? Pierre Panel (France) , Long-term evaluation of clinical results and quality of life for deeply infiltrating pelvic endometriosis,Michel Canis (France) , Hysteroscopic sterilization : state of the art, Sebastiaan Veersema (The Netherlands) , Prognostic factors of ovarian response and IVF outcome in patients with deep infiltrating endometriosis , Endometriosis and obstetrics : growing concerns of the maternal-fœtal interface. Louis Marcellin (France) , Claire Gauché-Cazalis (France) 14.45 Forum A-B-C Room - Satellite Sessions , The effect of the levongorgestrel intrauterine system to reduce endometrioma recurrence after laparoscopic cystectomy, 16.15 Understanding Deep Endometriosis from Diagnosis to Innovative Treatment Ikuko Ota (Japan) Chair : Kevin Stepp (USA) - Co-Chairs : Mauricio Abrao (Brazil) and Francisco Carmona (Spain) , Imaging diagnosis for endometriosis : state of the art, Scott Young (USA) Free communication 3 - Endometriosis Research - Forum I Room - Chair : Moamar Al-Jefout (Jordan) , Anatomical considerations for deep endometriosis, Rosanne M. Kho (USA) , Circulating miRNAs - potential biomarkers for endometriosis, Petra Pateisky (Austria) , Endometriosis : when and how to implement treatment ? Mauricio Abrao (Brazil) , Dienogest reduces the expression of midkine in the peritoneal fluid of women with endometriosis, , Innovative surgical treatment : moving towards scarless surgery, Kevin Stepp (USA) Konstantinos Nirgianakis (Switzerland) , FSLYM192050 : a new modality of treatment of Endometriosis, Ali-Farid Mohamed-Ali (Egypt) 16.15 Forum A-B-C Room - Satellite Session Identification of susceptibility genes for peritoneal, ovarian, and deep infiltrating endometriosis using a pooled sample-based genome-wide 16.45 , Live Scan association study, Bruno Borghese (France) Anne-Elodie Millischer (France) , Laser capture microdissection for women’s healthcare - a powerful tool for a better disease understanding, Eva Simon (Germany) Peritoneal fluid modifies the miRNA expression profile in endometrial and endometriotic cells from women with endometriosis, 14.45 Forum G-I-H-J Rooms - Satellite Session , Josep Marí-Alexandre (Spain) 16.45 Free communications Search for protein markers of endometriosis by proteomic studies of peritoneal fluid, Free communication 1 - Adenomyosis - Forum G Room - Chair : Isabelle Streuli (Switzerland) , Natalya V. Ermolova (Russia) Surgery promotes the development of endometriosis, Xishi Liu (China) , Adenomyosis ultrasound findings in patients with previously known endometriosis,Mariona Riu (Spain) , The clinical usefulness of endometrial biopsy to diagnose endometriosis in the work-up of women with infertility, , Influence of adenomyosis in qualility of life in deep infiltrating endometriosis patients,Maria-Angeles Martinez-Zamora (Spain) , Moamar Al-Jefout (Jordan) , Evidence for genetic signature of adenomyosis / endometriosis : first report of adenomyosis in monozygotic twin fetuses, Transcriptional changes in the expression of chemokines related to NK and T regulatory cells in patients with deep infiltrative endometriosis, Jelena Martinovic-Bouriel (France) , Patrick Bellelis (Brazil) , Prevalence of adenomyosis in patients with deep infiltrating endometriosis (die),Carlotta Zorzi (Italy) A relationship between inflammatory cytokine receptors and ion channel expression in endometriotic lesions, , COX2 and IL-1beta mRNA expression in adenomyosis, Patrizia Carrarelli (Italy) , Brett D. McKinnon (Switzerland) , Involvement of Hepatocyte Growth Factor-Induced Epithelial-Mesenchymal Transition in Human Adenomyosis, Khaleque Khan (Japan) ,, Reproductive outcome and deliveries following cytoreductive surgery for patients with adenomyosis, Ritsuo Honda (Japan) , GnRH agonsits may improve IVF performance in women with adenomyosis, Velja Mijatovic (The Netherlands) , Modern management of adenomyosis, Ksenia Krasnopolskaya (Russia)

13 14 Program 17.15 Forum G-I-H-J Room - Satellite Session 18.45 Russian speaking session Chair : Alexander Popov (Russia) - Co Chair : Vitali Bezenar (Russia) , Impact of endometriosis on oocyte and embryo quality in ART. Polina Lyatoshinskaya (Austria) FRIDAY 8TH OF MAY , Medical treatment for myomas : state of the art in 2015. Dace Matule (Latvia) , Endometriosis management : retrospective analysis of 1200 patients. Vitali Bezenar, Maria Yarmolinskaya (Russia) Free communication 4 - Other uterine disorders - Forum J Room - Chair : Carlos Augusto Souza (Brazil) , Adenomyosis and ART. Ksenia Krasnopolskaya (Russia) , Evaluation of clinical, ultrasonographic and hysteroscopic parameters in the differentiation of endometrial polyps and cancer of endome- , Should endometriomas really be operated ? Revaz Botchorishvili (France) trium, R Dias (Brazil) , Reproductive outcomes after uterine surgery. Alexander Popov, Anton Fedorov (Russia) , First results of the gynecological coelioscopy in the University Teaching Hospital of Dakar : a forward-looking series of 128 cases, , New sparing technics for patients with deep intestinal endometriosis. Konstantin Puchkov (Russia) Maguette Mbaye (Senegal) Single Incision laparoscopic salpingostomy in the treatment of tubal ectopic pregnancy : first clinical case series, 17.15 Forum A-B-C Room - Satellite Session , 18.45 Ying Woo (Singapore) Session SCGP / SEUD - En France et ailleurs - In France and elsewhere , Impact of sexually transmitted diseases in pregnancy : knowledge of pregnant women, Camila Batista Caixeta (Brazil) Let’s compare French and international positioning ! (French and English speaking session) , Laparoscopic metroplasty in bicornuate and didelphic uteri : feasibility and outcome, Saeed Alborzi (Iran) Chair : Arnaud Le Tohic (France) - Co Chair : Valérie Vernaeve (Spain) Office hysteroscopy in postmenopausal women : feasibility and correlation with transvaginal ultrasound, , Marine Sauvan (France) , Les patientes sont-elles demandeuses d’une hystérectomie ? Julien Niro (France) Prevention and early diagnose - education to youth, , Ofra Balaban (Israel) Do patients seek for hysterectomy ? Hilary Critchley (UK) Risk factors associate to endometrial neoplasia in patients submited to office hysteroscopy, , Douglas Silva (Brazil) , Traitements des endométriomes, François Golfier (France) Clinical factors associated to abnormal hysteroscopic findings in infertile patients, , Carlos Augusto Souza (Brazil) Endometrioma : what is the best option ? Errico Zupi (Italy) Ultrasound assesment of fibroids treated Ulipristal Acetate, , Maria-Jose Martinez-Serrano (Spain) , Recours au don d’ovocytes, Vanessa Gayet (France) Egg donation resort, Valérie Vernaeve (Spain) 16.45 Coffee break and exhibition visit 18.45 Scène B & C Room - Keynote lecture 17.15 Scène B & C Room - Plenary Session 19.15 18.45 Debate : Imaging for endometriosis and uterine disorders Abnormal Uterine Bleeding – an unmet need – current classification, causes and care Hilary Critchley (UK) Chair : Mauricio Abrao (Brazil) Chair : Hugh S. Taylor (USA) , In favour of transvaginal ultrasonography (TVUS), Anne-Elodie Millischer (France) , In favor of magnetic resonance imaging (MRI), Francisco Carmona (Spain) 20.30 Social Evening Debate : Surgery for deep endometriosis Chair : Bertrand Dousset (France) , In favor of complete and radical surgery, Joerg Keckstein (Austria) , In favor of less agressive surgery, Horace Roman (France)

15 16 Program 08.30 Forum IJ Room - Satellite Session - Chair : Sony S. Singh (Canada) 10.00 Videos session , Bladder endometriosis for the gynecologists - surgical treatment with the «T» shaped technique, Duarte Miguel Ribeiro (Brazil) , Surgical management of deep infiltrating bladder endometriosis,Kristina Arendas (Canada) SATURDAY 9TH OF MAY , Treatment of asherman’s syndrome in an outpatient hysteroscopy setting, Sony S. Singh (Canada) , Nerve sparing, utero sacral resection and ureteral resection-anastomosis by robot- assisted laparoscopy for deep infiltrating endometriosis, 08.30 Scène B & C Room - Plenary session Emmanuel Bailly (France) ® 10.00 Uterine fibroids , Ureteral resection for endometriosis with the AirSeal System , Arnaud Le Tohic (France) Chair : Tasuku Harada (Japan) - Co Chair : Michel Canis (France) , Combined transurethral approach with Versapoint® and laparoscopic treatment in the management of bladder endometriosis : tech- , Understanding the uterine fibroids pathogenesis,Pasquapina Ciarmela (Italy) nique, Pietro Litta (Italy) , Molecular basis for potential therapeutic targets, Bo R. Rueda (USA) , Nerve-sparing laparoscopic eradication of deep endometriosis with segmental rectal and parametrial resection : the negrar method. a , Strategy for myomas associated with infertility : surgery versus ART ? Gamal Serour (Egypt) prospective study on 331 patients, Marcello Ceccaroni (Italy) Adhesions prevention, , Jean-Luc Pouly (France) 10.00 Scène B & C Room - Keynote lecture , Discussion 10.30 Epigenetics and endometriosis 08.30 Forum G-H Rooms - Satellite Session Daniel Vaiman (France) 10.00 Free communications Chair : Sun-Wei Guo (China) Chair : Saeed Alborzi (Iran) Free communication 5 - Endometriosis Clinical - Forum G Room - 10.30 Coffee break and exhibition visit , Evaluating CA125 and VAS score modifications following GnRH Analogue to exclude superficial endometriosis as cause of chronic pelvic pain, Roberta Venturella (Italy) 11.00 Scène B & C Room - Plenary session , The use of vaginal gestrinone in Pentravan™ for the treatment of deep endometriosis-related pain, Hugo Maia Jr. (Brazil) 12.30 Prognostic factors of ART outcomes in a continuous series of 359 endometriosis patients, Chloe Maignien (France) Endometriosis : future and advances in research , Chair : Serdar E. Bulun (USA) - Co Chair : Bruno Borghese (France) , Prospective observational study on use of dienogest in women with endometriosis, Eliana Fuggetta (Italy) , Endometriosis and stem cells, Hugh S. Taylor (USA) , Evaluation of computed tomography enema and magnetic resonance imaging to diagnose multifocal and multicentric bowel lesions in , Pro-inflammatory signals and endometriosis pathogenesis : clinical applications, patients with colorectal endometriosis, Jeremie Belghiti (France) Frédéric Batteux (France) , A comparison of pelvic magnetic resonance imaging, trans-vaginal and trans-rectal sonography with laparoscopic findings in diagnosis of , Endometriosis and pelvic pain : relationship between nerves and inflammation, deep infiltrating endometriosis,Saeed Alborzi (Iran) Michael Mueller (Switzerland) Endometriosis : the optimal treatment of recurrent endometrioma in infertile patients. Smita Lakhotia (Singapore) , Fertility preservation for endometriosis women, Juan Garcia-Velasco (Spain) The main etiology of unexplained chronic pelvic pain is chronic parametropathia. Its accurate diagnostic method and its local non-surgical , , , Discussion treatment. Masao Igarashi (Japan) An exciting inaugural Free communication 6 - Endometriosis Research - Forum H Room - Chair : Antoine Bourret (France) conference for a new , Association between the concentration of human leukocyte antigens-g (hla-g) measured in follicular fluid and embryo quality in patients with endometriosis submitted to IVF cycles, Joao Cunha-Filho (Brazil) scientific society ! , Increased levels of circulating microparticles in deep infiltrating endometriosis,Maria-Angeles Martinez-Zamora (Spain) , Inhibition of apoptosis in a mouse model of induced menstruation, GM Armstrong (UK) Serdar E. Bulun , Intravenous laser therapy and use of recombinant Interleukin-1 and Interleukin-2 in the treatment of infertile endometriosis patients, Olga-Nikolaevna Kharkevich (Russia) , Pharmacodynamic effects and safety of the novel selective progesterone receptor modulator vilaprisan in healthy women, Beate Rohde (Germany) , Stress promotes the development of endometriosis in mice, Qiqi Long (China) , The origin of endometriosis based on genome-wide DNA methylation analysis, Yoshiaki Yamagata (Japan) , The transcriptional repressor BCL6 is a diagnostic biomarker for endometriosis and related infertility, Bruce A. Lessey (USA)

17 18 Program 12.30 Scène B & C Room 13.30 Nordic Pharma Symposium Adhesion prevention in endometriosis: a neglected critical challenge Chair : Horace Roman (France) SATURDAY 9TH OF MAY , Adhesions risks after endometriosis surgery, Markus Wallwiener (Germany) , Which place for the gels agents ? Horace Roman (France) 11.00 Forum G-H Rooms - Satellite Session 12.30 12.30 Cocktail lunch Free communications 13.30 Free communication 7 - Endometriosis Clinical - Forum G Room - Chair : Jo Kitawaki (Japan) , Continues Norethisterone Acetate versus Cyclical Drospirenone 3 mg/ethinyl Estradiol 20 ?g for the management of primary dysmenorrhea 13.30 Scène B & C Room - Plenary session in young adult females, Moamar Al-Jefout (Jordan) 15.30 KOL positions , Spontaneous hemoperitoneum in pregnancy (SHiP) and endometriosis : a review of the recent literature, M.C.I. Lier (The Netherlands) Chair : Francisco Carmona (Spain) - Co Chair : Michael Mueller (Switzerland) , Clinical correlation with laparoscopic features of peritoneal endometriosis, Daniel Spadoto-Dias (Brazil) , Is recurrence inevitable for endometriosis patients ? Michel Canis (France) , Pain evaluation and quality of life in endometriosis women undergoing IVF : a prospective controlled study, Mathilde Bourdon (France) , Hysteroscopy and the uterus: still a perfect marriage ? Stefano Bettocchi (Italy) , Correlation between magnetic resonance with gel and laparoscopy in the localization of deep endometriosis, Paolo Passoni (Italy) , Total hysterectomy : what is the better route (vaginal, robotic or laparoscopic) ? Rosanne M. Kho (USA) , Impact of ovarian endometrioma per se and surgery on ovarian reserve and pregnancy rate in IVF-ET cycles, Jo Kitawaki (Japan) , Taming the shrew : low-risk-ART for high risk patient is possible. Dominique de Ziegler (France) , Surgical diminished ovarian reserve (dor) after endometrioma cystectomy versus idiopathic dor : comparison of in vitro fertilization (IVF) 13.30 Forum G-I-H-J Rooms - Satellite Session outcome, Audrey Roustan (France) 15.30 Free communications Free communication 8 - Endometriosis Clinical - Forum H Room - Chair : Stefano Angioni (Italy) Free communication 9 - Endometriosis Clinical - Forum G Room - Chair : Lucia Lazzeri (Italy) Long term follow up of patients undergoing surgery for rectal endometriosis : conservative surgery seems being followed by better functio- , , Colorectal resection versus rectal conservative surgery in the management of rectal endometriosis : preliminary results of endore nal outcomes, Horace Roman (France) randomized trial, Horace Roman (France) Laparoscopic surgery for deep infiltrating endometriosis : the first Romanian experience, , Simedrea Voicu (Romania) , Results of implication of aromatase inhibitors in therapy of genital endometriosis, Maria Yarmolinskaya (Russia) Superficial peritoneal endometriosis : clinical aspects and risk factors, , Serena Pinzauti (Italy) , An evaluation of fluorescence imaging + ICG Dye (Firefly) for use in the visual diagnosis of endometriosis : a prospective study, Reproductive prognosis in women with endometriosis, , Maria-Cristina Cesana (Italy) Aileen Caceres (USA) Rectovaginal endometriosis resection without stoma: selection criteria, , Jean-Philippe Estrade (France) , Long-term effect of post-operative medication to reduce endometrioma recurrence, Yoshiaki Ota (Japan) Diagnostic delay of endometriosis : lessons that can be learned from the Dutch situation, , A. H. J. Staal (The Netherlands) , Management of deep infiltrating endometriosis by laparoscopic route with robotic assistance : 3 years experience, Knowledge and treatment strategies on endometriosis in Dutch General Practitioners, , Moniek van der Zanden (The Netherlands) Carole Abo (France) 11.00 Forum IJ Room - Satellite Session - Chair : Arnaud Le Tohic (France) , IVF/ICSI outcome in endometriosis patients is good whatever endometriosis location as soon as embryo transfer is performed, 12.30 Videos session Jean-Philippe Estrade (France) Deep endometriosis is associated with the highest level of perceived stress: effect of surgical treatment, Lucia Lazzeri (Italy) , Ovarian endometrioma - The robotic treatment using the «zones» technique, Duarte Miguel (Brazil) , The ureteral involvement is frequent in case of posterior deep pelvic endometriosis. About 242 patients, Clothilde Poupon (France) , Hysteroscopic management of a stenotic cervix, Michael W.H. Suen (Canada) , Anti-Mullerian Hormone trend after laparoscopic surgery in women with ovarian endometrioma, Federica Esposito (Italy) , Laparoscopic hysterectomy for large uterus, Arnaud Le Tohic (France) , A prospective pilot study to evaluate feasibility of group education for endometriosis patients, Kristina Arendas (Canada) , Combined vaginal-laparoscopic-transanal approach in large deep endometriotic nodules, Horace Roman (France) , , The Rouen technique : combined laparoscopic and transanal disc excision of large deep endometriosis of lower and mid rectum, Horace Roman (France) , Surgical tips to deal with adenomyosis, Yoshiaki Ota (Japan) , Pelvic pain and vascular entrapment, Pierre Panel (France)

19 20 Program Free communication 12 - Other uterine disorders - Forum J Room - Chair : Claudia Tosti (Italy) , Safety of total laparoscopic hysterectomy in adenomyosis/leiomyoma patients with prior cesarean section, Joohyun Choi (South Korea) , Comparation among the main hysterectomy routes, Pedro Olsen (Brazil) SATURDAY 9TH OF MAY , Determinants of birth interval among reproductive age group women in Ethiopia, Tebikew Yeneabat (Ethiopia) , Development of a curriculum in hysteroscopy : Delphi method, Marie-Emmanuelle Neveu (France) Free communication 10 - Endometriosis Clinical - Forum H Room - Chair : Serena Pinzauti (Italy) , Fertility after myomectomy in Dakar, Mouhamadou Mansour Niang (Senegal) , Dienogest in the treatment of endometriosis: a retrospective analysis of quality of life, Letizia Freschi (Italy) , Hypermobile Ehlers Danlos syndrome : a differential diagnosis for gynecologist, Anne Gompel (France) , Efficacy of surgical intervention on pre-operative symptoms and quality of life in patients with endometriosis, , Increased progesterone receptor expression in uterine leiomyoma, Claudia Tosti (Italy) Zara Fonseca-Kelly (Ireland) , Laparoscopic surgery at low pressure (7 mmHg) with AirSeal® System : a comparative prospective pilot study with a standard insufflation , Diaphragmatic endometriosis : when should we think about ? Marta Lempicki (France) (15 mmHg) in 60 patients, Jérémy Sroussi (France) , Effect of endometrioma excisional technique on the ovarian reserve : a case control study, Stefano Angioni (Italy) , Reducing uterine size with ulipristal acetate to avoid morselation of uterus in laparascopic hysterectomy, Boris Bacic (Croatia) , Physical therapy and endometriosis : using manual therapy to assist in pain management, Sallie Sarrel (USA) , Hysteroscopic evaluation of uterine cavity after conservative management of placenta accreta, Irène Letendre (France) , Administration of epinastine may contribute to early natural conception in the women with endometriosis following laparoscopic surgery, 15.30 Toshio Igarashi (Japan) Scène B & C Room - Plenary session 16.00 , Is endometriosis associated with autoimmune disorders ? Ludovica Imperiale (Italy) Closing and awards ceremony Chair : Charles Chapron (France) - Co Chair : Francisco Carmona (Spain) , Development of a French version of the Endometriosis Health Profile (EHP-5) : cross-cultural adaptation and comparison with the EQ-5D, The awards will only be given to the winners present during the ceremony Arnaud Fauconnier (France) , Does the surgical management of DPE affect the outcome of pregnancies in patients with endometriosis-related pelvic pain?, 16.30 Forum G-H-I-J Room Carlo Saccardi (Italy) 17.45 Patient session , Time interval between menarche and surgery for endometriosis is not correlated to endometriosis phenotype, Chairs : Dr Sophie Lemonier (Médecin journaliste) - Mme Yasmine Candau (Présidente EndoFrance) Serena Pinzauti (France) Actualités 2015 sur l'endométriose Comment améliorer le diagnostic ? Pierre Panel (France) Free communication 11 - Endometriosis Research - Forum I Room - Chair : Inaki Gonzales (Spain) , , Quelle stratégie thérapeutique ? Charles Chapron (France) , Comparative morphometric characteristics of eutopic and ectopic endometrial cells in patients with endometriomas (Federal Scientific Research Institute of Obstetrics and Pediatrics, Rostov-on-Don, Russia), Svetlana Dubrovina (Russia) , Discovery of a novel specific safe anti-endometriosis drug : 3-Ethylpyridine: specific inhibitor of CD44 and Tenascin,since CD44 and Tenascin are etiology of endometriosis, Masao Igarashi (Japan) , Impact of a stress-reduction program on psychological well-being in women with endometriosis : preliminary results, Sara de Pinho Cunha-Paiva (Brazil) , Genome-wide pathway analysis highlight the role of Wnt signaling in endometriosis, Outi Uimari (UK) , Reduced levels of endometrial stem cell factor in women with endometriosis results in an accumulation of uNK progenitor cell, Uma Thiruchelvam (Irland) , Role of integrin expression in pathophysiology of endometriosis, Alexander Popov (Russia) , Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity, Iñaki González-Foruria (Spain) , The effect of curcumin on the oocyte-granulosa cell interaction of bovine cumulus-oocyte complex in peritoneal fluid culture of infertile women with endometriosis, Hendy Hendarto (Indonesia) , Understanding LGR5 as a prognostic and diagnostic marker for endometriosis, Xavier Santamaria (Spain) , Upregulation of autophagy in ovarian endometriosis, Stefano Luisi (Italy)

21 22 SOCIAL PROGRAM BATEAUX MOUCHES VISIT OF THE EIFFEL TOWER Social program Location : Pont de l'Alma , Rive Droite - Port de la Conférence Location : Eiffel Tower, Champ de Mars, 75007 Paris 75008 Paris (appointment at the North Pier, in front of the Hours : Every 30 min from 10AM to 7PMand every 20 min G.Eiffel statue) from 7PM to 11PM Hours : Every 30min from10AM to 5PM Duration : 1h15min (language: French or English) Price : 12,50€ Duration : 1h30min Contact : [email protected] Price : 22,90€ Thursday 7th of may 18:45 Reservation : Please refer to www.seud-congres.com Contact : [email protected] WELCOME RECEPTION How to get there? : Metro 9, stop at “Alma Marceau” Reservation : Please refer to www.seud-congres.com Free access for this reception which will take place in the How to get there? : Metro 6, stop at “Bir Hakeim” exhibition hall at 18h45. Welcome reception is included in congress fee.

DECKER BUS (THE OPEN TOUR BY CITY VISION) VISIT OF THE CATHEDRAL NOTRE DAME Location : 13, rue Auber 75009 Paris Location : 6, Parvis Notre-Dame - Place Jean-Paul II, Hours : Every 10 or 15 minutes, (languages: French, English, 75004 Paris Japanese, Russian, Italian, Chinese..) Hours : From 10AM to 6PM Duration : Paris Grand Tour (2.00 hrs) / Montparnasse Price : 8,50€ Saint-Germain (1.00hr)/ Montmartre - Grands Boule- Contact : [email protected] vards (1.20 hrs)/ Bastille - Bercy (1.00 hr ) Reservation : Please refer to www.seud-congres.com Price : 32€ How to get there? : Contact : [email protected] • Metro 4, stop at “Cité” or “Saint-Michel” Reservation : Please refer to www.seud-congres.com • Metro 1 or 11, stop at “Hôtel de Ville” How to get there? : It depends of the itinerary you choose. • Metro 10, stop at “Maubert-Mutualité” or “Cluny – La Sorbonne” • Metro 7, 11, and 14, stop at “Châtelet” Friday 8th of may 20:30 • RER : Line B or C, stop at “Station Saint-Michel - SOCIAL EVENING AT MUSÉE DES ARTS Notre-Dame” FORAINS Nestled in the heart of the Bercy district of Paris, housed in the wine market built by a student of Gustave Eiffel. Its creator, John Paul Favand, gathered over 35 years, thousands of rare objects : old fairground pieces, objects of show (theater, music hall) and VISIT OF THE ARC DE TRIOMPHE curiosities. This museum is a massive live performance scene in Location : Place Charles de Gaulle, 75008 Paris which the public is an actor of his own dreams. Hours : From 10AM to 11PM Social Evening : 60€ Price : 9,50€ Contact : [email protected] Reservation : Please refer to www.seud-congres.com How to get there? : Metro 1, 2 or 6, stop at “Charles de Gaulle-Etoile”

24 25 Paris, a fabulous heritage PARTNERS

RICH, VAST AND EXTRAORDINARY: façade and its ceiling painted by Marc Chagall. Finally, a trip out to PARIS’S HERITAGE IS TRULY the Père Lachaise cemetery offers the opportunity to pay homage at the tombs of many famous people. EXCEPTIONAL, COMBINING BOTH HISTORICAL AND MODERN TREASURES. UNUSUAL MUSEUMS: With its incomparable heritage and profusion of sites and monu- PARIS’S ALTERNATIVE HERITAGE ments, Paris is a dream destination for visitors in search of historic The Louvre and the Pompidou Centre are far from being the only splendour. Thanks to its unique blend of iconic sights, innovative museums in Paris. The city has many lesser known, often private, architecture and unusual places, the French capital promises a museums that are well worth going out of your way to visit, such cultural journey like no other through 1,803 monuments, 173 as the Musée de l’Erotisme in Pigalle, which displays erotic art museums and a host of other exceptional sites. works from around the world. Another quirky place to visit is the Musée des Egouts comprising the largest network of sewers in The top things to do on a first-time visit: enjoy a panoramic view the world, showing what Paris looks like below ground. The other of the city from a 324-metre height at the top of the Eiffel Tower, major underground attraction, the Paris Catacombs dating from admire Victor Hugo’s beloved gargoyles at Notre Dame Cathedral Roman times, is a labyrinthine network housing the remains of and stand at the top of the tallest hill in Paris at the Sacré Cœur more than six million Parisians transferred here from the city’s Basilica. These are the three monuments most popular with vi- cemeteries. The Catacombs draw a constant stream of visitors, sitors to Paris. Not far from Notre Dame Cathedral, the Sainte though only 200 people are allowed inside at a time. Chapelle with its beautiful stained glass windows is also well worth visiting. There is a completely different atmosphere at the Musée des Arts Forains, where visitors can relive the experience of a 19th-cen- A short distance from the Champs-Elysées, the Grand Palais, a tury funfair and learn how to restore an ancient merry-go-round. huge stone, steel and glass structure, hosts prestigious exhibi- Another museum in a 19th-century Napoleon III townhouse, the tions. Built by Napoleon, the Arc de Triomphe offers a breathta- Musée du Parfum, gives visitors an unforgettable insight into per- king bird’s-eye view of the city. fume and the history of traditional perfume making at the Frago- nard factory. In the heart of Paris, the Louvre is a former royal residence which was transformed into a museum after the Revolution and has since become the world’s most visited museum. The Mu- sée d’Orsay houses the largest collection of Impressionist and post-Impressionist paintings in the world. Another must-see is the Palais Garnier with its ornately decorated

26 Partners SymposiaSymposia on the occasion of the Society of Endometriosis and Uterine Disorders Congress 7-9 May 2015, Paris–France

® DIAMOND SPONSOR Current and future perspectives: Visanne and new research targets in endometriosis Chair: Carlos Petta, Brazil May 7, 2015 • 9:45-11:45 • Room Scène B

Why approach endometriosis as an inﬂ ammatory disease? Pietro Santulli, France Tailoring endometriosis treatment: medical and surgical options GOLD SPONSOR Renato Seracchioli, Italy Evidence-based management of endometriosis with Visanne® Andreas D. Ebert, Germany How can we best manage our patients for the long term? Sony Sukhbir Singh, Canada Bayer’s future medical treatment options Thomas M. Zollner, Germany Q&A, summary, own experience and close SILVER SPONSOR Carlos Petta, Brazil Original New insights to Mirena® in the management of heavy menstrual bleeding

Chair: Hervé Fernandez, France May 7, 2015 • 12:15-13:45 • Room Scène B

The global burden of HMB Joaquin Calaf, Spain How does Mirena® compare to other treatments for HMB? Find fromBRONZE PDF recreate PMSSPONSOR Marc-Yvon Arsenault, Canada Mirena® in the management of HMB in special patient groups Oskari Heikinheimo, Finland Q&A session Hervé Fernandez, France SPONSOR We invite you to visit us at our booth.

G.WH.FC.03.2015.0679

28 v_150461_brand_ad_v1_21cm_x_28cm_v1.pdf 1 4/3/15 10:42 AM

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