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89 Abstract Biological Activity and Analytical
BIOLOGICAL ACTIVITY AND ANALYTICAL CHARACTERIZATION OF BARBITURIC ACID Vijaya Laxmi S, Janardhan B, Rajitha B ijcrr Vol 04 issue 07 Department of Chemistry, National Institute of Technology, Warangal Category: Review Received on:12/12/11 E-mail of Corresponding Author: [email protected] Revised on:15/01/12 Accepted on:28/02/12 ABSTRACT Earlier literature reports imply that this scaffold is having activity on central nervous system. According to the present studies it has become an attractive target for the development of drugs, which hold variety of biological activities. Derivatives of barbituric acid have attracted the attention of researchers in synthetic organic chemistry, as well as medicinal chemistry, for a long time as a result of their exceptionally diverse biological activity. Present review highlights the importance of the barbituric acid in the present context. ____________________________________________________________________________________ Keywords: Barbituric acid, Biological activity, biological activities that stand apart from Spectral studies, X-ray Crystallography, Dye previous medical utilization of barbituric acid properties. derivatives.4 However it is a precursor to barbituric acid derivatives widely been used in 1 INTRODUCTION the manufacturing of plastics,5 textiles,6 Barbituric acid (BA) is documented as the parent polymers,7 and pharmaceuticals,8-9 dental compound of the barbiturate drugs. (Fig.1). It is materials,10 water thinned or oil-based inks,11 used in the production of riboflavin, Nembutal, and as polymerization catalysts.12 In view of the and Phenobarbital.1-2 This class of compounds above observations it is worthwhile to make a has been extensively used in medical and brief review on it. -
The Design and Synthesis of Novel Barbiturates of Pharmaceutical Interest
University of New Orleans ScholarWorks@UNO University of New Orleans Theses and Dissertations Dissertations and Theses 5-21-2004 The Design and Synthesis of Novel Barbiturates of Pharmaceutical Interest Donna Neumann University of New Orleans Follow this and additional works at: https://scholarworks.uno.edu/td Recommended Citation Neumann, Donna, "The Design and Synthesis of Novel Barbiturates of Pharmaceutical Interest" (2004). University of New Orleans Theses and Dissertations. 1040. https://scholarworks.uno.edu/td/1040 This Dissertation is protected by copyright and/or related rights. It has been brought to you by ScholarWorks@UNO with permission from the rights-holder(s). You are free to use this Dissertation in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itself. This Dissertation has been accepted for inclusion in University of New Orleans Theses and Dissertations by an authorized administrator of ScholarWorks@UNO. For more information, please contact [email protected]. THE DESIGN AND SYNTHESIS OF NOVEL BARBITURATES OF PHARMACEUTICAL INTEREST A Dissertation Submitted to the Graduate Faculty of the University of New Orleans in partial fulfillment of the requirements for the degree of Doctor of Philosophy in The Department of Chemistry by Donna M. Neumann B. A. University of New Orleans, 2000 May 2004 Dedicated to: My daughter, Madeline Megan Jenkins ii ACKNOWLEDGEMENTS I would like to express my utmost gratitude to my advisor, Professor Branko S. -
List of Spectra /Compound Names
IS NIR Spectra Complete collection (6049 spectra) This collection includes all NIR spectra collected within this project. Those are organic and inorganic chemicals, pharmaceutical excipients, drugs, polymers, additives, coatings, dyes, pigments, toxic substances, hazardous substances like explosives, agrochemicals and other types of materials. This collection should be chosen by customers with broad range of analytical applications. The near infrared spectral library „IS NIR Spectra“ is a unique collection of 6049 NIR (near infrared) digital spectra. The spectra have been collected in range 4200-10000 cm-1 (=2.4 – 1 micrometers). „IS NIR Spectra“ is the biggest and newest NIR library available on the market. This spectral library has been designed for users who use their NIR spectrometer not only for quantitative and chemometric analysis, but also want to identify unknown samples or just want to use the library as reference spectra database. ra t IS means “Intergrating Sphere” and at the same time “Identify Samplec”. e Technical parameters: p The „IS NIR Spectra“ were collected using the FT-NIR Spectrometer equipped with Integrating Sphere Accessory. Resolution: standard 4cm-1 IR Customized resolution: upon special request the speNctra can be delivered in customized resolution to reach better correspondence with spectr a collected by customer NIR instrument Spectral range in wavenumbers units: 4200-1000I0S cm-1 Spectral range in wavelength units: 2.4 – 1 micr ometers Only one spectrum/compound covering the mentioned spectral range Typical text information about the sample inmcludes (when available): Compound name including synonyms o CAS number .c Chemical formula a Molecular weight tr Additional information about thec sample like manufacturer and comments. -
Chromic Phenomena the Technological Applications of Colour Chemistry
Chromic Phenomena The Technological Applications of Colour Chemistry Peter Bamfield Consultant ISBN 0-8404-474-4 A catalogue record for this book is available from the British Library © The Royal Society of Chemistry 2001 All rights reserved. Apart from any fair dealing for the purpose of research or private study, or criticism or review as permitted under the terms of the UK Copyright, Designs and Patents Act, 1988, this publi- cation may not be reproduced, stored or transmitted, in any form or by any means, without the prior permission in writing of The Royal Society of Chemistry, or in the case of reprographic reproduction only in accordance with the terms of the licences issued by the Copyright Licensing Agency in the UK, or in accordance with the terms of the licences issued by the appropriate Reproduction Rights Organization outside the UK. Enquiries concerning repro- duction outside the terms stated here should be sent to The Royal Society of Chemistry at the address printed on this page. Published by The Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge CB4 0WF, UK Registered Charity Number 207890 For further information see our web site at www.rsc.org Typeset in Great Britain by Wyvern 21 Ltd, Bristol Printed by MPG Books Ltd, Bodmin, Cornwall, UK Preface The aim of this book is to provide an overview of the many applications that colour chemistry, in its widest sense, has found in the last couple of decades. Not only have there been developments in the traditional areas of colorants for textiles, paints and inks but also in an exciting variety of newer technologies. -
Chem 263 Dec 2, 2010 Note That Another Carbon Dioxide Derivative Is
Chem 263 Dec 2, 2010 Note that another carbon dioxide derivative is a urethane. Some derivatives of these may be polymerized to form polyurethane. O O NH2 The alkylation product of dimethyl malonate shown last class can be alkylated again, as there is another alpha proton present. O O O O O 1) Base H2O, HCl H3CO OCH3 H3CO OCH3 HO heat H 2) CH3CH2I O CO2 H2N NH2 2 CH3OH O HN NH O O The product from this reaction, dimethyl 2,2-diethylmalonate, can be used to perform other reactions as shown above. Dimethyl 2,2-diethylmalonate can be treated with base or acid and water to form a dicarboxylic acid (hydrolysis), which can react further upon heating to lose carbon dioxide, as shown in the figure below. Alternately, dimethyl 2,2-diethylmalonate can react with urea to form barbital (diethyl barbiturate). O O O O 1) NaOH H CO OCH HO OH 3 3 2) HCl heat O OH OH H OH transfer 2-ethylbutyric acid Upon heating (denoted by the triangle), the dicarboxylic acid loses one of its carboxylic groups (CO2). This process is called decarboxylation. The product from this step is an enol. Upon treating with acid, we get a substituted acetic acid, specifically 2-ethylbutyric acid as the product. Dimethyl 2,2-diethylmalonate can also be used as a synthetic precursor for drugs. O O O O NH NH + H3CO OCH3 (heat) H2N NH2 urea O O Barbital Barbital (or diethyl barbiturate) belongs to a class of drugs called barbiturates. It is a sleeping pill used widely in the 1950’s. -
United States Patent (19) (11) 4,428,887 Tou Et Al
United States Patent (19) (11) 4,428,887 Tou et al. 45) Jan. 31, 1984 54 METHOD OF PRODUCING MONO-SUBSTITUTED TERMINAL FOREIGN PATENT DOCUMENTS DESTERS 146496 7/1902 Fed. Rep. of Germany . (75) Inventors: Jacob S. Tou; Alfred A. Schleppnik, 1059M 1/1962 France . both of St. Louis, Mo. 940533 10/1963 United Kingdom. 73 Assignee: Monsanto Company, St. Louis, Mo. OTHER PUBLICATIONS 21 C. A. Bischoff, Ber. 29 (1), 966–967, (1896). Appl. No.: 398,060 D. A. White, S. Synthetic Comm. 7 (8), 559-568, (1977). (22) Filed: Jul. 14, 1982 Holden and Lapworth, J. Chem. Soc., 2368-2373, 51 Int. Cl. ..................... CO7C 120/00; CO7C 67/34 (1931). (52) U.S. Cl. ............................. 260/465 D; 260/465.4; Primary Examiner-Natalie Trousof 560/81; 560/190; 560/203 Assistant Examiner-Vera C. Clarke (58) Field of Search ................. 560/190, 193, 203, 81; Attorney, Agent, or Firm-Scott J. Meyer; James W. 260/465 D, 465.4 Williams, Jr, (56) References Cited 57 ABSTRACT U.S. PATENT DOCUMENTS Mono-substituted terminal diesters of malonic acid are 1,869,666 8/1932 Chaux et al. ........................ 544/304 prepared by reaction of the corresponding substituted 1,954,429 4/1934 Shonle ................................. 544/306 1,2-diesters with alkali metal hydride in the presence of 2,153,730 4/1939 Volwiler et al. 544/305 X organic solvent medium. 2,872,448 2/1959 Doran ................ ... 544/306 2,876,225 3/1959 Donnison ............................ 260/257 4 Claims, No Drawings 4,428,887 1. 2 5-Ethyl-5-(1-methylbutyl)barbiturate, (Nembutal (R), METHOD OF PRODUCING . -
(CASRN 105-53-3) (Diethyl Malonate) Final Designation
Supporting Information for Low-Priority Substance Propanedioic Acid, 1,3-Diethyl Ester (CASRN 105-53-3) (Diethyl Malonate) Final Designation February 20, 2020 Office of Pollution Prevention and Toxics U.S. Environmental Protection Agency 1200 Pennsylvania Avenue Washington, DC 20460 Contents 1. Introduction ................................................................................................................................................................ 1 2. Background on Diethyl Malonate ............................................................................................................................. 3 3. Physical-Chemical Properties ................................................................................................................................... 4 3.1 References ....................................................................................................................................................... 6 4. Relevant Assessment History ................................................................................................................................... 8 5. Conditions of Use ....................................................................................................................................................... 9 6. Hazard Characterization .......................................................................................................................................... 12 6.1 Human Health Hazard .................................................................................................................................. -
September 17, 2007
Executive Summary of Asahi Songwon Colors Ltd. (Unit-III) Plot No. T-79 to T-96, Saykha Industrial Estate, Saykha, Tehsil: Vagra, Dist.: Bharuch-392140 Proposed Project for Manufacturing of Pigments, Phthalic Anhydride and Pigment Intermediates (6205 TPM) Project Activity: 5(f), Category: B 1. INTRODUCTION Asahi Songwon Colors Ltd. is a leading player in the Indian Pigment industry and intends to become a leading manufacturer of pigments around the world. The company is in the manufacturing of CPC Beta Blue and Blue Crude, exporting substantial production to leading MNCs around the world on account of quality of its products. The global dyes and pigments market is projected to reach USD 42.00 billion by 2021, at a CAGR of 5.0% from 2016 to 2021. The growth of the market is primarily due to increasing population, coupled with growing demand for dyes & pigments from various applications, such as textile, paints & coatings, and plastics, among others. Thus, Asahi Songwon Colors Ltd.(Unit-III) proposes to manufacture Pigments, Phthalic Anhydride and pigment intermediates at Plot No. T-79 to T-96, Saykha Industrial Estate, Saykha, Tehsil: Vagra, Dist.: Bharuch. The area of the site is 115,000 m2. Location of the proposed project in industrial estate and 5km and 10 km radius around the location are shown below. 2. COST OF PROJECT The estimated cost of the project is estimated around Rs. 372.8 crores. Estimated Cost in Rs. Crores Land and Land Development 25 Buildings - Civil & structural work 47.5 Godowns/Engg Stores 16.8 Electric Room 12.05 Plant and Machinery 208 Utility Equipments 43.75 Miscellaneous Fixed Assets 8.2 ETP plant & Machinery 30 Stores & Spares 6.5 Total 372.8 Asahi Songwon Colors Ltd. -
A Comparison of Barbituric Acid, Thiobarbituric Acid and Malonylguanidine As Quantitative Precipitants for Furfural
Proceedings of the Iowa Academy of Science Volume 23 Annual Issue Article 10 1916 A Comparison of Barbituric Acid, Thiobarbituric Acid and Malonylguanidine as Quantitative Precipitants for Furfural Arthur W. Dox Iowa Agricultural Experiment Station G. P. Plaisance Iowa Agricultural Experiment Station Let us know how access to this document benefits ouy Copyright ©1916 Iowa Academy of Science, Inc. Follow this and additional works at: https://scholarworks.uni.edu/pias Recommended Citation Dox, Arthur W. and Plaisance, G. P. (1916) "A Comparison of Barbituric Acid, Thiobarbituric Acid and Malonylguanidine as Quantitative Precipitants for Furfural," Proceedings of the Iowa Academy of Science, 23(1), 41-50. Available at: https://scholarworks.uni.edu/pias/vol23/iss1/10 This Research is brought to you for free and open access by the Iowa Academy of Science at UNI ScholarWorks. It has been accepted for inclusion in Proceedings of the Iowa Academy of Science by an authorized editor of UNI ScholarWorks. For more information, please contact [email protected]. Dox and Plaisance:PRECIPITANTS A Comparison of BarbituricFOR FURFURAL Acid, Thiobarbituric Acid and Malonylg41 A COMPARISON OF BARBITURIC ACID, THIOBARBI- TURIC ACID AND MALONYLGUANIDINE AS QUANTI TATIVE PRECIPITANTS FOR FURFURAL. ARTHUR W. DOX AND G. P. PLAISANCE. All of the methods for the quantitative determination of pentoses and pentosans in agricultural products are based upon the conversion of pentose. into furfural by distillation with a mineral acid, preferably hydrochloric, and subsequent estima tion of furfural in the distillate by means of a suitable reagent. Giinther, Chalmot and Tollens1 titrated the furfural with phen- ylhydrazine, using aniline acetate paper as an indicator. -
INVENTORY LIST – VERSION June 2012
EuPIA European Printing Ink Association a sector of CEPE aisbl INVENTORY LIST – VERSION June 2012 COMPRISING OF PACKAGING INK RAW MATERIALS APPLIED TO THE NON-FOOD CONTACT SURFACE OF FOOD PACKAGING 12/06/2012 EuPIA Inventory List – Notes & Lists 1. Preliminary note The EuPIA Guideline on Printing Inks Applied to the Non-Food Contact Surface of Food Packaging Materials and Articles already includes a scheme for the careful selection of raw materials to be used in the manufacture of food packaging inks. Nevertheless, EuPIA had decided additionally to make publicly available a list of all the substances used in the manufacture of food packaging inks, with the aim of implementing a transparent tool for packaging converters and brand owners. At the same time the list is intended to become a reference for competent authorities. Since then, the Swiss Ordinance on Materials and Articles has been amended with provisions specific to food packaging inks. The core element of the new regulation is a list of permitted substances identifying the only substances to be used in the manufacture of food packaging inks marketed in Switzerland. However, it is the intention of EuPIA to collate and develop its own inventory list, allowing for the most flexible way of providing update information such that the latest status of substances/raw materials used in food packaging inks is represented. Printing inks and varnishes for food packaging are intended to be applied to a variety of substrates using different printing techniques, such as: • Rotogravure and flexographic -
Isometric Isoindoline Yellow Pigment Isometrisches Isoindolin-Gelbpigment Pigment Jaune Isométrique Du Type Isoindoline
(19) & (11) EP 2 231 785 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: C09B 67/14 (2006.01) C09B 67/20 (2006.01) 18.01.2012 Bulletin 2012/03 C09B 57/04 (2006.01) C08K 5/00 (2006.01) (21) Application number: 08860392.3 (86) International application number: PCT/EP2008/067011 (22) Date of filing: 08.12.2008 (87) International publication number: WO 2009/074533 (18.06.2009 Gazette 2009/25) (54) ISOMETRIC ISOINDOLINE YELLOW PIGMENT ISOMETRISCHES ISOINDOLIN-GELBPIGMENT PIGMENT JAUNE ISOMÉTRIQUE DU TYPE ISOINDOLINE (84) Designated Contracting States: (72) Inventors: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR • HAINZ, Rüdiger HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT 79589 Binzen (DE) RO SE SI SK TR • ALLAZ, Jean CH-4147 Aesch (CH) (30) Priority: 10.12.2007 EP 07122749 • SCHROEDER, Didier 02.06.2008 EP 08157426 F-68330 Huningue (FR) (43) Date of publication of application: (56) References cited: 29.09.2010 Bulletin 2010/39 EP-A- 0 029 007 EP-A- 0 038 548 WO-A-99/38920 WO-A-2005/085364 (73) Proprietor: BASF SE DE-A1- 2 041 999 DE-A1- 2 628 409 67056 Ludwigshafen (DE) DE-B- 1 012 406 DE-B1- 2 757 982 FR-A- 1 537 299 US-A- 4 262 120 US-A- 4 384 057 US-A- 5 091 532 Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. -
Synthesis of 5-Methylene(Thio)Ureas (Thio)Barbiturates As Potential Xanthine Oxidase Inhibitors
UNIVERSIDADE DA BEIRA INTERIOR Ciências Synthesis of 5-methylene(thio)ureas (thio)barbiturates as potential xanthine oxidase inhibitors Eunice Cerdeira Soares Cavalheiro Dissertação para obtenção do Grau de Mestre em Química Medicinal (2º ciclo de estudos) Orientador: Prof. Doutor Samuel Martins Silvestre Co-orientador:Prof. Doutora Vânia Moreira Covilhã, fevereiro de 2017 Folha em branco ii Para os meus pais, iii Folha em branco iv Agradecimentos/ Acknowledges Em primeiro lugar gostaria de agradecer ao Professor Doutor Samuel Silvestre e ao Professor Doutor Paulo Almeida pela possibilidade de desenvolver este projeto e por toda a orientação, apoio, disponibilidade e confiança durante ao longo de todo o processo. Also I would like to express my gratitude to Professor Dr. Vânia Moreira and Dr. Leena Keuruleinen for allowing me to carry out part of the organic synthesis of this project on the Drug Discovery group of the Division of Pharmaceutical Chemistry and Technology of the Faculty of Pharmacy of the University of Helsinki, Finland. I would like to thank all the continuous support, guidance and kindness during development of this project Agradeço a todos os meus colegas e amigos de laboratório Mafalda Catarro, João Serrano, Joana Figueiredo e João Marques por todo o auxílio e por todos os bons momentos passados. Gostaria de prestar um agradecimento também a Sara Garcia, companheira de aventuras do programa Erasmus e grande amiga, pelo apoio nos momentos mais difíceis e pela motivação durante o processo de escrita da tese. Por último gostaria de agradecer à minha família, com especial atenção aos meus pais, irmão e avós que me apoiaram durante todo o meu período académico, encorajando-me a continuar os meus estudos e a conquistar muitas vitórias na vida.