Hydrocortisone/Mazipredone 1537

Hydrocortisone Tablets; Hydrocortisone Valerate Cream; Hydrocortisone HC; ratio-Proctosone; Rectogel HC; Rivasol HC; Sterex Plus; Uremol-HC; Valerate Ointment; Neomycin and Polymyxin B Sulfates and Hydrocorti- Vioform-Hydrocortisone; VoSoL HC†; Chile: Cortifenol H†; Fucidin H; sone Acetate Cream; Neomycin and Polymyxin B Sulfates and Hydrocorti- Otex HC; Cz.: Ciprobay HC Otic; Dobexil Plus†; Fucidin H; Ophthalmo- OH sone Acetate Ophthalmic Suspension; Neomycin and Polymyxin B Sulfates Framykoin Compositum; Otosporin; Pimafucort; Proctosedyl†; Septomix- and Hydrocortisone Ophthalmic Suspension; Neomycin and Polymyxin B ine; Denm.: Brentacort; Ciflox; Fucidin-Hydrocortison; Hydrocortison O Sulfates and Hydrocortisone Otic Solution; Neomycin and Polymyxin B Sul- med Terramycin; Hydrocortison med Terramycin og Polymyxin-B; Locoidol; fates and Hydrocortisone Otic Suspension; Neomycin and Polymyxin B Sul- Proctosedyl; Fin.: Ciproxin-Hydrocortison; Daktacort; Duocort; Fucidin- H H C fates, Bacitracin Zinc, and Hydrocortisone Acetate Ophthalmic Ointment; 3 OH Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Hydrocortison; Locoidol†; Pantyson; Pimafucort; Proctosedyl; Sibicort; Ter- HO Ointment; Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydro- ra-Cortril; Terra-Cortril P; Trosycort; Xyloproct†; Fr.: Bacicoline; Madecas- cortisone Ophthalmic Ointment; Neomycin and Polymyxin B Sulfates, Baci- sol Neomycine Hydrocortisone†; Ger.: Antiprurit†; Baycuten HC; Can- H3C H tracin, and Hydrocortisone Acetate Ointment; Neomycin and Polymyxin B esten HC†; Corti Jaikal†; Farco-Tril†; Fucidine plus†; Hydrodexan; Sulfates, Bacitracin, and Hydrocortisone Acetate Ophthalmic Ointment; Ichthocortin; Novifort†; Nystaderm comp; Pigmanorm; Polyspectran HC; Neomycin and Polymyxin B Sulfates, Gramicidin, and Hydrocortisone Ace- Posterisan Forte†; Terracortril†; Gr.: Ciprofloxacin HY†; Cortiphenol H; F H tate Cream; Neomycin Sulfate and Hydrocortisone Acetate Cream; Neo- Daktodor; Fucidin H; Hydrofusin; Terra-Cortril; Hong Kong: Anusol-HC†; mycin Sulfate and Hydrocortisone Acetate Lotion; Neomycin Sulfate and Canesten HC; Cipro HC; Corticin†; Cortiphenol H; Daktacort; Fucidin H; O Hydrocortisone Acetate Ointment; Neomycin Sulfate and Hydrocortisone Hemcort HC†; Hydro-Funga; Micosone; Otosporin; Posterisan Forte; (isoflupredone) Acetate Ophthalmic Ointment; Neomycin Sulfate and Hydrocortisone Ac- Proctosedyl†; Proctosone†; Xyloproct; Hung.: Chlorocid-H†; Ciprobay†; etate Ophthalmic Suspension; Neomycin Sulfate and Hydrocortisone Cream; Neomycin Sulfate and Hydrocortisone Ointment; Neomycin Sul- Fucidin H; Otosporin; Oxycort; Pimafucort; Posterisan Forte; Tetran-Hy- fate and Hydrocortisone Otic Suspension; Oxytetracycline Hydrochloride drocortison; India: Bell Diono Resolvent; Bell Resolvent; Belmycetin-C; Pharmacopoeias. In US for veterinary use only. and Hydrocortisone Acetate Ophthalmic Suspension; Oxytetracycline Hy- Cortison Kemicetine†; Cortola-m; Cortoquinol; Crotorax-HC; Daktacort; USP 31 (Isoflupredone Acetate). Protect from light. drochloride and Hydrocortisone Ointment; Polymyxin B Sulfate and Hy- Efcorlin; Furacin-S; Genticyn HC†; Keralin; Medithane; Multifungin H†; Ne- drocortisone Otic Solution. osporin-H; Pino-Cort; Proctosedyl; Shield; Wycort c Neomycin; Indon.: Profile Isoflupredone acetate is a corticosteroid that has been used for its Proprietary Preparations (details are given in Part 3) Anusol-HC; Brentan; Chloramphecort; Dermacort; Enpicortyn; Haemo- caine; Indoson; Kemiderm; Nufacort; Particol; Ramicort; Sancortmycin; Ter- topical glucocorticoid activity (p.1490) in allergic rhinitis. Arg.: Alfacort; Anusol-HC; Azuthidrona; Cortenem†; Demacort; Efficort†; Fridalit; Hidrotisona; Idenona†; Lactid HC; Locoid; Medrocil; Microsona; ra-Cortril; Thecort; Viohydrocort; Visancort; Zolacort; Irl.: Alphaderm; Al- Isoflupredone is also employed in veterinary medicine. Oralsone; Schericur; Sirotamicin HC; Stiefcortil; Transderma H; Austral.: phosyl HC†; Anugesic-HC; Anusol-HC; Calmurid HC; Canesten HC; Colifoam; Cortaid†; Cortef; Cortic; Derm-Aid; Egocort; Hycor; Hysone; Daktacort; Eurax-Hydrocortisone; Fucidin H; Gentisone HC; Locoid C; Preparations Sigmacort; Siguent Hycor; Solu-Cortef; Austria: Colifoam; Ekzemsalbe F; Nystaform-HC†; Otosporin; Perinal; Proctofoam-HC; Proctosedyl; Quino- Proprietary Preparations (details are given in Part 3) Hydoftal sine neomycino; Hydrocortone; Hydroderm; Locoidon; Retef; cort†; Timodine; Vioform-Hydrocortisone; Xyloproct; Israel: Alphosyl Multi-ingredient: Israel: Proaf. Belg.: Azacortine; Buccalsone†; Cortril†; Cremicort-H; Locoid; Nozema; HC†; Benzantine H; Calmurid HC†; Ciproxin HC; Daktacort; Epifoam; Fu- Pannocort; Solu-Cortef; Braz.: Berlison; Cortisonal; Cortiston; Cortizol; cidin H†; Hycocin; Hycomycin; Hydroagisten; Panthisone; Perinal; Procto- Cortizon; Hidrocortex; Hidyn H; Locoid; Nutracort; Solu-Cortef†; Stief- Glyvenol; Proctofoam-HC; Proctozorin-N; Xyloproct†; Ital.: Argisone; cortil; Therasona; Westcort; Canad.: A-Hydrocort†; Barriere-HC; Claritin Cort-Inal; Cortison Chemicetina; Emorril; Fucidin H; Idracemi; Idracemi Loteprednol Etabonate (BANM, USAN, rINNM) ⊗ Skin Itch Relief; Cortate; Cortef; Cortenema; Cortifoam; Cortoderm; Der- Eparina; Idrocet†; Idroneomicil†; Kinogen; Mictasone; Mixotone; Mobilat; maflex HC; Dermarest Dricort Anti-Itch; Emo-Cort; Hycort; Hyderm; Hy- Nasomixin; Nevacort; Prepacort H; Preparazione Antiemorroidaria†; CDDD-5604; Etabonato de loteprednol; HGP-1; Lotéprednol, drosone; HydroVal; Novo-Hydrocort; Prevex HC; Sarna HC; Solu-Cortef; Westcor t; Chile: Aquanil HC; Calmurid; Cortisol; Efficort; Hipoge; Lacti- Proctidol; Proctofoam-HC; Proctosedyl; Proctosoll; Reumacort; Scalpicin; Etabonate de; Loteprednol Ethyl Carbonate; Loteprednoli Etab- care-HC†; Locoid; Nutracort; Nutralona†; Pandel; Solu-Cortef; Vitulpas†; Sedalen Cort†; Vasosterone; Vasosterone Antibiotico; Vasosterone Collir- onas; P-5604. (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy- Cz.: Laticort†; Locoid; Solu-Cortef†; Denm.: Colifoam; Locoid; Mildison; io; Malaysia: Becacort†; Candacort; Cipro HC†; Crotamiton H; Dakta- 3-oxoandrosta-1,4-diene-17-carboxylic acid chloromethyl ester. Solu-Cortef; Uniderm; Fin.: Ampikyy; Apocort; Bucort; Colifoam; Kyypa- cort; Decocort; Foban-Hydro; Fucidin H; Miconazole H†; Neo-Hydro†; kkaus; Locoid; Nutracort†; Solu-Cortef; Fr.: Aphilan; Calmicort†; Colo- Pocin H; Proctosedyl; Proctosone†; Setarin H†; Ucort; Xyloproct; Zari- Лотепреднола Этабонат foam; Cortapaisyl; Cortisedermyl; Dermaspraid Demangeaison; Der- cort†; Mex.: Angenovag; Biotarson N; Ciproxina HC; Clioderm-H; Cortis- C24H31ClO7 = 467.0. mofenac†; Efficort; Hydracort; Locoid; Mitocortyl; Proctocort†; Ger.: porin; Daktacort; Dermanol; Hidrofenil; Hidropolicin; Litiset; Ofodex; Ore- CAS — 129260-79-3 (loteprednol); 82034-46-6 (lotepre- Alfason; Colifoam; Dermallerg†; Dermo Posterisan†; Ebenol; Fenistil Hy- cil NF; Otifar; Oto Eni; Otolone†; Poral; Soldrin; Sulfa Hidro; Ultracortin; dnol etabonate). drocort; Ficortril; Glycocortison†; Hydro-Wolff†; Hydrocort†; Hydrocutan; Vioformo-Cort; Xyloderm; Xyloproct Plus; Neth.: Bacicoline-B; Calmurid Hydrocutan mild; Hydroderm HC; Hydrogalen; Laticort; Linola Cort Hy- ATC — S01BA14. HC; Daktacort; Otosporin; Pimafucort; Proctosedyl; Terra-Cortril Gel Ster- ATC Vet — QS01BA14. dro; Munitren; Pandel; Posterine Corte†; Posterisan cort; ratioAllerg†; aject met polymyxine-B†; Terra-Cortril met polymyxine-B; Norw.: Dakta- Remederm HC; Sanatison Mono; Soventol HC; Systral Hydrocort; velop- Profile ural†; Gr.: Colifoam; Filocot; Lyo-Cortin†; Nutracort†; Rolak; Solu-Cortef; cort; Fucidin-Hydrocortison; Locoidol; Proctosedyl; Terra-Cortril; Terra- Hong Kong: Cortef; Derm-Aid; Dhacort; Efficort†; Egocort; Hycortin†; Cortril Polymyxin B; Xyloproct; NZ: Ciproxin HC; Daktacort; DP Lotion - Loteprednol etabonate is a corticosteroid used for its glucocorti- Hydrosone; Hytisone; Lacticare-HC†; Sigmacort; Solu-Cortef; Hung.: Cor- HC; Fungocort†; Locoid C; Micreme H; Pimafucort; Proctosedyl; Xylo- coid activity (p.1490) in the topical management of inflammato- tef; Laticort; Locoid; Solu-Cortef; India: Cipcorlin; Cutisoft; Entofoam; proct; Philipp.: Cortisporin; Daktacort; Fucidin H; Hydrospor; Isonep H; ry and allergic disorders of the eye. It is usually used as eye drops Wycort; Indon.: Berlicort; Calacort; Enkacort; Lexacorton; Locoid; Stero- Proctosedyl; Trimycin-H; Pol.: Atecortin; Chlorchinaldin H; Daktacort†; containing 0.2 or 0.5%. derm; Irl.: Colifoam; Corlan; Cortopin; Dioderm; Hc45; Hydrocortisyl; Hy- Hemcort HC; Laticort-CH; Oxycort; Pimafucort; Posterisan H; Proctos- drocortone; Locoid; Mildison†; Solu-Cortef; Israel: Cortifoam; Cortizone; one; Port.: Anucet; Clorcorticil†; Corticil T; Daktacort; Davimicina†; Fuci- Prolonged application to the eye of preparations containing cor- Efficort; Lanacort; Solu-Cortef; Ital.: Colifoam; Cortaid†; Cortidro; Cor- dine H; Leuco Hubber†; Locoid C†; Otosporin; Pimafucort; Proctonos- ticosteroids has caused raised intra-ocular pressure and reduced top; Dermirit; Dermocortal; Efficort†; Flebocortid; Foille Insetti; Idracemi; trum†; Rus.: Cortomycetin (Кортомицетин); Fucidin H (Фуцидин Г); visual function. Lanacort; Lenirit; Locoidon; Sintotrat; Solu-Cortef; Jpn: Pandel; Malaysia: Gioxyson (Гиоксизон); Oxycort (Оксикорт); Pimafucort (Пимафукорт); ◊ References. Derm-Aid; Dhacort†; Efficort; Egocort; H-Cort; Hydrocort; Solu-Cortef; Posterisan Forte (Постеризан Форте); Relief Ultra (Релиф Ультра); Mex.: Aquanil HC; Collicort; Efficort; Fadol; Flebocortid; Flemex; Icorsan; 1. Noble S, Goa KL. Loteprednol etabonate: clinical potential in Lacticare-HC; Locoid; Microsona; Nositrol; Nutracort; Solhidrol; Westcort; S.Afr.: Calmurid HC†; Ciprobay HC; Daktacort; Fucidin H; Nasomixin†; Neoderm; Otosporin; Proctofoam†; Proctosedyl; Terra-Cortril; Viocort; the management of ocular inflammation. BioDrugs 1998; 10: Neth.: Buccalsone; Cremicort; Locoid; Mildison; Solu-Cortef; Norw.: Col- 329–39. ifoam; Locoid; Mildison; Solu-Cortef; NZ: BK HC; Colifoam; Derm-Aid; DP Singapore: Candacort; Canesten HC; Ciprobay HC; Cortaid with Aloe†; Hydrocortisone; Egocort; Lemnis Fatty Cream HC; Lipocort; Locoid; Mild- Daktacort; Decocort; Fucidin H; Hydroderm-C; Micon-H; Neo-Hydro; Preparations ison; Skincalm; Solu-Cortef; Philipp.: Cortizan; Droxiderm; Efficort; Hy- Proctosedyl; Zaricort; Spain: Aftajuventus; Aftasone B C; Anginovag; Anti- Proprietary Preparations (details are given in Part 3) cortil; Hydrotopic; Lacticare-HC; Pharmacort; Solu-Cortef; Pol.: Corhy- hemorroidal; Bacisporin; Brentan; Cilinafosal Hidrocortisona; Ciproxina; Arg.: Alrex; Lopred; Lotemax; Lotesoft; Braz.: Alrex†; Ger.: Lotemax; Gr.: dron; Laticort; Locoid; Procortin; Port.: Colifoam; Dermimade Cohortan; Cortenema; Cortison Chemicet Topica; Dermo Hubber; De- Lotemax; Hong Kong: Lotemax; India: Loteflam; Ital.: Lotemax; Mex.: Hidrocortisona†; Hidalone; Hydrocortone; Lactisona; Locoid; Pandel; Pan- traine; Edifaringen; Fucidine H; Grietalgen Hidrocort†; Halibut Hidrocorti- Loterex; Singapore: Lotemax; UK: Lotemax; USA: Alrex; Lotemax; Ven- dermil; Rapicort; Solu-Cortef; Rus.: Cortef (Кортеф); Laticort sona; Hemodren Compuesto†; Hepro; Leuco Hubber; Milrosina Nistatina; ez.: Lotesoft. (Латикорт); Locoid (Локоид); Solu-Cortef (Солу-кортеф)†; Sopolcort N Neo Hubber; Oto Difusor†; Oto Vitna†; Otosporin; Roberfarin; Terra- (Сополькорт Н); S.Afr.: Biocort; Colifoam†; Covocort; Cutaderm†; Dilu- Multi-ingredient: Arg.: Lotemicin. cort; Locoid; Mylocort; Procutan; Solu-Cortef; Stopitch; Singapore: Cortril; Tisuderma; Swed.: Cortimyk; Daktacort; Fenuril-Hydrokortison; Derm-Aid; Dhacort; Efficort; Egocort; Hydrocort; Hydroderm; Solu-Cor- Fucidin-Hydrocortison; Proctosedyl†; Terracortril; Terracortril med poly- tef; Spain: Actocortina; Aftasone; Ceneo; Dermosa Hidrocortisona; He- myxin B; Xyloproct; Switz.: Calmurid HC†; Ciproxin HC; Cortifluid N; modren; Hemorrane; Hidroaltesona; Hidrocisdin; Isdinium; Lactisona; Oral- Cortimycine; Daktacort; Dermacalm-d; Fucidin H; Haemocortin; Hydro- Mazipredone (rINN) ⊗ sone; Scalpicin Capilar; Schericur; Suniderma; Swed.: Colifoam; Ficortril; cortisone compositum; Neo-Hydro; Otosporin; Septomixine; Terracor- Locoid; Mildison; Solu-Cortef; Uniderm; Switz.: Alfacortone; Glycocorti- tril†; Thai.: Antergan†; Candacort; Daktacort; Decocort; Dermasol; Do- Mazipredona; Maziprédone; Mazipredonum. 11β,17-Dihydroxy- sone H†; Hydrocortone; Locoid; Sanadermil; Solu-Cortef; Thai.: Hytisone; proct; Fucidin H; Ladocort; Otosporin†; Proctosedyl; Turk.: Cormisin; 21-(4-methyl-1-piperazinyl)pregna-1,4-diene-3,20-dione. Prevex HC; Solu-Cortef; Turk.: Cortimycine; Hipokort; Locoid; UAE: Al- Kortos; Ma-Ka-Ta; Ureacort; UK: Actinac; Alphaderm; Alphosyl HC; Anug- Мазипредон facort; UK: Colifoam; Corlan; Cortopin; Cortropin; Dermacort; Dioderm; esic-HC; Anusol-HC, Plus HC; Calmurid HC; Canesten HC; Daktacort; C H N O = 442.6. Efcortelan; Efcortesol; Exe-Cort; Hc45; Hydrocortistab; Hydrocortone; La- Daktacort HC; Econacort; Eurax-Hydrocortisone; Fucidin H; Gentisone 26 38 2 4 nacort; Locoid; Mildison; Solu-Cortef; Zenoxone; USA: A-Hydrocort; Ac- HC; Germoloids HC; Gregoderm†; Locoid C; Nystaform-HC; Otosporin; CAS — 13085-08-0. ticort; Ala-Cort; Anucort-HC; Aquanil HC; Bactine; CaldeCort; Carmol HC; Cetacort; Colocort; Cort-Dome; Cortaid; Cortef; Cortef Feminine Perinal; Proctofoam-HC; Proctosedyl; Terra-Cortril†; Timodine; Uniroid- Itch; Cortenema†; Corticaine; Cortifoam; Cortizone; Dermarest Dri-Cort; HC; Vioform-Hydrocortisone; Xyloproct; USA: 1 + 1-F; Acetasol HC; Al- Dermol HC; Dermolate; EarSol-HC; Gynecort; Hemril-HC; Hi-Cor; Hy- cortin; Analpram-HC; AnaMantle HC; Anumed HC; Cipro HC; Coly-Mycin CH3 drocortone; HydroSkin; Hytone; Lacticare-HC; Lanacort; Locoid; Massengill S Otic; Corque; Cortane-B; Cortatrigen; Cortic ND; Corticaine; Cortimy- Medicated; Neutrogena T/Scalp; Nutracort; Orabase HCA; Pandel; Pene- cin; Cortisporin; Cortisporin-TC; Cortisporin†; Cyotic; Dermtex HC with N cort; Procort; Proctocort; Proctocream HC 2.5%; Recort Plus; Solu-Cortef; Aloe; Ear-Eze; Emergent-Ez; Enzone; Epifoam; Fungoid HC; HC Derma-Pax; Synacort; Tegrin-HC; Texacort; U-Cort; Westcort; Venez.: Corticina; Effi- HC Pramoxine; Hysone; LazerSporin-C; LidaMantle HC; Mediotic-HC; Ne- cort; Hidrocort; Hidrozona; Histasona†; Lacticare-HC†; Liocort; Nutracort; otricin HC; Novacort; Octicair†; Oti-Med†; Otic-Care; OtiTricin; Otobiotic; Pantocort†; Solu-Cortef; Stricort. Otocort; Otomar-HC; Otomycin-HPN; Otosporin; Pediotic; Pramosone; N Multi-ingredient: Arg.: Aeromicrosona C†; Alercortil†; Antibiocort†; Proctofoam-HC; Terra-Cortril; Tri-Otic†; UAD-Otic; Vanoxide-HC; VoSoL O Anusol Duo; Anusol Duo S; Atomoderma Plus; Bactisona; Bexon; Biocort- HC†; Vytone; Xyralid; Zone-A; Zoto-HC; Venez.: Hipoglos con Hidrocor- in†; Cipro HC; Ciprocort; Ciproflox-Otic; Ciriax Otic; Ciriax Otic L; Colirio tisona†; Otalex; Quinotic HC; Terra-Cortril†. H H3C Antibiotico CNH; Cristalomicina; Delos Otic; Dercotex; Derivoco†; Derm- HO OH operative; Disel Hidrocortisona; Epiprocto; Gentacler; Gramicortil†; Grise- oplus; Hidrocortin†; Hipoglos con Hidrocortisona; Irigal; Lactiderm HC†; H C H Lidocort Proct; Linfol Dermico; Masivol Urea; Micozol Compuesto†; Micro- 3 sona C; Microsona Otica; Monizol Cort; Neo Pelvicillin; Otex HC; Oto Biotaer; Otobiotic; Otocipro; Otoseptil; Otosporin; Otosporin C; Ot- Isoflupredone Acetate (BANM, USAN, rINNM) ⊗ H H osporin L; Procto-Ikatral; Proctocrem; Prootocipro; Prurisedan Biotic†; Quemicetina con Hidrocortisona; Reacur†; Start NP†; Terra-Cortril; Terra- Cortril Nistatina†; Tocorectal; Tricur; Tridermal; Triefect†; Vagicural; Xilo- Acetato de isoflupredona; 9α-Fluoroprednisolone Acetate; Isof- O cler; Xyloprocto; Austral.: Ciproxin HC; Hydroform; Hydrozole; Proctos- luprédone, Acétate d’; Isoflupredoni Acetas; U-6013. 9α-Fluoro- edyl; Rectinol HC; Resolve Plus; Xyloproct; Austria: C-Bildz; Calmurid HC; 11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate. Profile Cortison Kemicetin; Hydoftal; Hydrocortimycin; Ichtho-Cortin; Otosporin; Mazipredone is a corticosteroid used topically for its glucocorti- Tropoderm; Belg.: Daktacort; Eoline†; Fucidin Hydrocortisone; Onctose a coid activity (p.1490). It is used as the hydrochloride with mico- l’Hydrocortisone; Otosporin†; Terra-Cortril; Terra-Cortril + Polymyxine B; Изофлупредона Ацетат Braz.: Anusol-HC; Cipro HC; Gingilone; Hemodotti; Hidrocorte; Hidro- nazole in the treatment of fungal infections of the skin. neo†; Nitrolerg†; Otociriax; Otosporin; Terra-Cortril; Vioformio-Hidrocor- When applied topically, particularly to large areas, when the skin C23H29FO6 = 420.5. tisona; Xyloproct; Canad.: Anodan-HC; Anugesic-HC; Anusol-HC; Anuz- is broken, or under occlusive dressings, corticosteroids may be inc HC; Anuzinc HC Plus; Cipro HC; Cortimyxin; Cortisporin; Egozinc-HC; Fucidin H; Neo-Cortef†; Pentamycetin-HC; Pramox HC; Proctodan-HC; CAS — 338-95-4 (isoflupredone); 338-98-7 (isoflupre- absorbed in sufficient amounts to cause systemic effects Proctofoam-HC; Proctol; Proctomyxin HC; Proctosedyl; ratio-Hemcort- done acetate). (p.1490). The effects of topical corticosteroids on the skin are The symbol † denotes a preparation no longer actively marketed The symbol ⊗ denotes a substance whose use may be restricted in certain sports (see p.vii) 1538 Corticosteroids described on p.1492. For recommendations concerning the cor- CAS — 83-43-2. 1 in 1.5 of water and 1 in 12 of alcohol; very slightly soluble in rect use of corticosteroids on the skin, see p.1497. ATC — D07AA01; H02AB04. acetone; insoluble in chloroform and in ether. Store in airtight Preparations ATC Vet — QD07AA01; QD10AA02; QH02AB04. containers. Protect from light. Proprietary Preparations (details are given in Part 3) Stability. Methylprednisolone sodium succinate injection (So- Cz.: Depersolon†; Hung.: Depersolon†. lu-Medrol, USA) was considered to be stable for 7 days when Multi-ingredient: Cz.: Mycosolon†; Hung.: Mycosolon; Pol.: Mycoso- O diluted in water for injection and stored in glass vials at 4°. When lon; Rus.: Mycosolon (Микозолон). OH stored under similar conditions at 22°, it was considered to be H3C OH 1 HO stable for 24 hours. The manufacturers state that the prepared solution should be stored at 20 to 25° and used within 48 hours of mixing. Medrysone (USAN, pINN) ⊗ H3CH 1. Nahata MC, et al. Stability of diluted methylprednisolone sodi- 11β-Hydroxy-6α-methylprogesterone; Medrisona; Médrysone; um succinate injection at two temperatures. Am J Hosp Pharm Medrysonum; NSC-63278; U-8471. 11β-Hydroxy-6α-methyl- HH 1994; 51: 2157–9. pregn-4-ene-3,20-dione. O Медризон Adverse Effects, Treatment, Withdrawal, CH3 C22H32O3 = 344.5. and Precautions CAS — 2668-66-8. As for corticosteroids in general (see p.1490). Rapid ATC — S01BA08. Pharmacopoeias. In Eur. (see p.vii), Jpn, and US. intravenous injection of large doses has been associat- ATC Vet — QS01BA08. Ph. Eur. 6.2 (Methylprednisolone). A white or almost white, ed with cardiovascular collapse. crystalline powder. It shows polymorphism. Practically insoluble in water; sparingly soluble in alcohol; slightly soluble in acetone Methylprednisolone may be slightly less likely than H3C O and in dichloromethane. Protect from light. prednisolone to cause sodium and water retention. USP 31 (Methylprednisolone). A white to practically white, When applied topically, particularly to large areas, H3C odourless, crystalline powder. Practically insoluble in water; sol- HO uble 1 in 100 of alcohol, and in 1 in 800 of chloroform and of when the skin is broken, or under occlusive dressings, corticosteroids may be absorbed in sufficient amounts H3CH ether; slightly soluble in acetone; sparingly soluble in dioxan and in methyl alcohol. Store in airtight containers. Protect from light. to cause systemic effects. HH ◊ References to various adverse effects associated with intrave- Methylprednisolone Acetate (BANM, rINNM) ⊗ nous methylprednisolone in high-dose pulse therapy1-11 and to O Acetato de metilprednisolona; Methylprednisolon-acetát; adverse effects after intra-articular12,13 and intranasal injection.14 Méthylprednisolone, acétate de; Methylprednisoloni acetas; Epidural dosage (or more particularly inadvertent intrathecal CH 3 Metilprednizolon Asetat; Metilprednizolon-acetát; Metilpredni- dosage during attempted epidural placement) may be associated zolono acetatas; Metylprednisolonacetat; Metyyliprednisolonia- with serious adverse effects including arachnoiditis and aseptic 15 Profile setaatti. Methylprednisolone 21-acetate. meningitis, although the degree of risk is uncertain. Medrysone is a corticosteroid used for its glucocorticoid activity 1. Newmark KJ, et al. Acute arthralgia following high-dose intra- (see p.1490) in the topical treatment of allergic and inflammatory Метилпреднизолона Ацетат venous methylprednisolone therapy. Lancet 1974; ii: 229. conditions of the eye. It is usually given as 1% eye drops. C24H32O6 = 416.5. 2. Bailey RR, Armour P. Acute arthralgia after high-dose intrave- CAS — 53-36-1. nous methylprednisolone. Lancet 1974; ii: 1014. Prolonged use of ophthalmic preparations containing corticoster- ATC — D07AA01; H02AB04. 3. Bennett WM, Strong D. Arthralgia after high-dose steroids. oids has caused raised intra-ocular pressure and reduced visual ATC Vet — QD07AA01; QH02AB04. Lancet 1975; i: 332. function. 4. Moses RE, et al. Fatal arrhythmia after pulse methylprednisolo- Pharmacopoeias. In Eur. (see p.vii) and US. ne therapy. Ann Intern Med 1981; 95: 781–2. Preparations Ph. Eur. 6.2 (Methylprednisolone Acetate). A white or almost 5. Oto A, et al. Methylprednisolone pulse therapy and peritonitis. Proprietary Preparations (details are given in Part 3) white, crystalline powder. Practically insoluble in water; sparing- Ann Intern Med 1983; 99: 282. Austral.: HMS†; Port.: Medrisocil†; USA: HMS†. ly soluble in alcohol and in acetone. Protect from light. 6. Suchman AL, et al. Seizure after pulse therapy with methyl prednisolone. Arthritis Rheum 1983; 26: 117. USP 31 (Methylprednisolone Acetate). A white or practically 7. Ayoub WT, et al. Central nervous system manifestations after white, odourless, crystalline powder. Soluble 1 in 1500 of water, pulse therapy for systemic lupus erythematosus. Arthritis Rheum 1983; 26: 809–10. Meprednisone (USAN, rINN) ⊗ 1 in 400 of alcohol, 1 in 250 of chloroform, and 1 in 1500 of ether; sparingly soluble in acetone and in methyl alcohol; soluble 8. Williams AJ, et al. Disseminated aspergillosis in high dose ster- Meprednisona; Méprednisone; Meprednisonum; 16β-Methyl- in dioxan. Store in airtight containers at a temperature of 25°, ex- oid therapy. Lancet 1983; i: 1222. prednisone; NSC-527579; Sch-4358. 17α,21-Dihydroxy-16β- 9. Barrett DF. Pulse methylprednisolone therapy. Lancet 1983; ii: cursions permitted between 15° and 30°. Protect from light. 800. methylpregna-1,4-diene-3,11,20-trione. 10. Baethge BA, Lidsky MD. Intractable hiccups associated with Мепреднизон Methylprednisolone Hydrogen Succinate high-dose intravenous methylprednisolone therapy. Ann Intern Med 1986; 104: 58–9. C22H28O5 = 372.5. (BANM, rINNM) ⊗ 11. Gardiner PVG, Griffiths ID. Sudden death after treatment with CAS — 1247-42-3. Hidrogenosuccinato de metilprednisolona; Methylprednisolone pulsed methylprednisolone. BMJ 1990; 300: 125. ATC — H02AB15. 12. Black DM, Filak AT. Hyperglycemia with non-insulin-depend- ATC Vet — QH02AB15. Hemisuccinate; Méthylprednisolone, Hémisuccinate de; Méthyl- ent diabetes following intraarticular steroid injection. J Fam prednisolone, Hydrogénosuccinate de; Methylprednisolon-hy- Pract 1989; 28: 462–3. drogen-sukcinát; Methylprednisoloni Hemisuccinas; Methylpred- 13. Pollock B, et al. Chronic urticaria associated with intra-articular methylprednisolone. Br J Dermatol 2001; 144: 1228–30. OH nisoloni hydrogenosuccinas; Metilprednizolon-hidrogén-szuk- 14. Johns KJ, Chandra SR. Visual loss following intranasal corti- cinát; Metilprednizolono-vandenilio sukcinatas; Metylprednisolo- costeroid injection. JAMA 1989; 261: 2413. O nvätesuccinat; Metyyliprednisolonivetysuksinaatti. Methylpred- 15. Rodgers PT, Connelly JF. Epidural administration of methyl- H C nisolone 21-(hydrogen succinate). prednisolone for back pain. Am J Hosp Pharm 1994; 51: 3 OH 2789–90. O Метилпреднизолона Гемисукцинат CH3 C H O = 474.5. H3C H 26 34 8 Interactions H CAS — 2921-57-5. ATC — D07AA01; H02AB04. The interactions of corticosteroids in general are de- H H ATC Vet — QD07AA01; QH02AB04. scribed on p.1494. O Pharmacopoeias. In Eur. (see p.vii), Jpn, and US. Ph. Eur. 6.2 (Methylprednisolone Hydrogen Succinate). A white Pharmacokinetics Pharmacopoeias. In US. or almost white, hygroscopic powder. Practically insoluble in For a brief outline of the pharmacokinetics of corticos- USP 31 (Meprednisone). Store in airtight containers at a temper- water; slightly soluble in dehydrated alcohol and in acetone; dis- teroids, see p.1495. ature not exceeding 40°. Protect from light. solves in dilute solutions of alkali hydroxides. Store in airtight containers. Protect from light. Methylprednisolone is fairly rapidly distributed after Profile USP 31 (Methylprednisolone Hemisuccinate). A white or nearly oral doses, with a plasma half-life of 3.5 hours or more. Meprednisone is a corticosteroid with mainly glucocorticoid ac- white, odourless or nearly odourless, hygroscopic solid. Very The tissue half-life is reported to range from 18 to 36 tivity (p.1490). It has been given orally as either the free alcohol slightly soluble in water; freely soluble in alcohol; soluble in ac- hours. or the acetate and by injection as the sodium hemisuccinate. etone. Store in airtight containers. Preparations Methylprednisolone acetate is absorbed from joints over a week but is more slowly absorbed following Proprietary Preparations (details are given in Part 3) Methylprednisolone Sodium Succinate Arg.: Cortipyren B; Deltisona B; Latisona B; Prednisonal; Prenolone; Rupe- (BANM, rINNM) ⊗ deep intramuscular injection. The sodium succinate es- sona B; Mex.: Lectan. Methylprednisolone Sodium Hemisuccinate; Méthylprednisolo- ter is rapidly absorbed after intramuscular doses, with ne, Succinate Sodique de; Methylprednisoloni Natrii Succinas; peak plasma concentrations obtained in 2 hours. Metilprednizolon Sodyum Süksinat; Succinato sódico de metil- Methylprednisolone crosses the placenta. prednisolona. Methylprednisolone 21-(sodium succinate). Methylprednisolone (BAN, rINN) ⊗ ◊ References. Метилпреднизолона Натрия Сукцинат Meilprednizolon; Methylprednisolon; Méthylprednisolone; 6α- 1. Tornatore KM, et al. Repeated assessment of methylprednisolo- C H NaO = 496.5. Methylprednisolone; Methylprednisolonum; Metilprednisolona; 26 33 8 ne pharmacokinetics during chronic immunosuppression in renal CAS — 2375-03-3. transplant recipients. Ann Pharmacother 1995; 29: 120–4. Metilprednizolon; Metilprednizolonas; Metylprednisolon; Me- ATC — D07AA01; H02AB04. 2. Rohatagi S, et al. Pharmacokinetics of methylprednisolone and tyyliprednisoloni; NSC-19987. 11β,17α,21-Trihydroxy-6α-meth- ATC Vet — QD07AA01; QH02AB04. prednisolone after single and multiple oral administration. J Clin ylpregna-1,4-diene-3,20-dione. Pharmacol 1997; 37: 916–25. Pharmacopoeias. In US. 3. Tornatore KM, et al. Pharmacokinetics and pharmacodynamic Метилпреднизолон USP 31 (Methylprednisolone Sodium Succinate). A white or response of methylprednisolone in premenopausal renal trans- C22H30O5 = 374.5. nearly white, odourless, hygroscopic, amorphous solid. Soluble plant recipients. J Clin Pharmacol 2004; 44: 1003–11.