2.Tests for Krok 2 Industrial Technology of Drugs 1.Pdf 836.59KB
Total Page:16
File Type:pdf, Size:1020Kb
1. Analytical normative documentation, technological processes and devices 1. A pharmaceutical enterprise starts to produce a new production. In which part of an industrial technological regulation the external look, physicochemical properties of the prepared product are described ? A. description of the technological process B. characteristics of prepared production C. characteristics of raw material and intermediate product D. characteristics of auxiliary raw material E. informative materials 2. In which part of an industrial technological regulation the sanitary preparation of the working area is described? A. labour safety standards, fire safety and manufacture sanitation B. description the stages of the technological process and manufacture sanitation C. informative materials D. general characteristics of manufacture E. safe exploitation of the manufacture, manufacture preservation of the environ- ment 3. Choose an analytical normative document which qualifies the standards of composition of the medical preparation and process of its production: A. technological regulation, pharmacopoeia article B. technical regulation C. state standard D. branch standard E. technical conditions 4. Various preparations are produced in a pharmaceutical factory according to technological rules. How long is industrial manufacturing rules are valid? A. 6 months B. 1 year C. 3 years D. 5 years E. 8 years 5. Indicate an analytical normative document that is confirmed only for the lim- ited term and determines the quality standards of the medicine: A. state standard B. technical regulation (TR) C. temporary pharmacopoeia article D. branch standard E. technical conditions 6. This normative document comprises requirements to concrete products and services, regulates relations between a supplier and customer. Give the term to the definition: A. standard B. technical conditions C. technical regulations D. technological regulations E. methodological guidelines 7. Choose the most appropriate definition of output-input characteristics (factor of account): A. correlation of the initial amount of materials to the mass of prepared product and by-product B. correlation of the mass of product to the mass of initial materials C. correlation of the mass of losses to the mass of initial materials D. correlation of the mass of initial materials to the mass of final product E. correlation sum of the initial materials and prepared product to the mass of material losses 8. Choose the economic requirements to the materials and apparatus : A. Equipment investments, designing expenses, expenses for production and assembling B. accordance of the temperature C. rate of movement D. comfort of exploitation E. stocked durability 9. According to the demand of GMP WHO the production of sterile preparations at the factory are classified on “clean” areas. Choose classes of cleanness in accordance with the requirements of the characteristic of an air: A. A, B B. A, B, C, D C. I, II, III D. I, II E. A, Б, В, Г, Д 10. What devices are commonly used for mixing of dry substances and powders? A. mixers with a corps which is revolved B. quasi-liquefaction apparatus C. mixers of centrifugal action D. oscillation sieves E. many-tier sieves 2 11. Different types of dryers are used to dry the granules.What type of dryer does SP-30 belong to? A. dryers with a quasi-liquefaction layer B. sublimation dryer C. infra-red dryer D. dryer with a silica gel E. dryer with the forced circulation of air 12. Powders are prepared at the pharmaceutical enterprise. What apparatus is used for drying powders which have a residual moisture? A. air-circulation dryer B. chamber vacuum dryer C. sublimation dryer D. dryer SG-30 E. vacuum drying oven (cupboard) 13. A pharmaceutical enterprise produces powders for preparing injections. What apparatus is used for drying these powders? A. chamber vacuum dryer B. sublimation dryer C. spray(-type) dryer D. dryer SG-30 with quasi-liquefaction layer E. air-circulation dryer 14. Different types of dryers are used at a pharmaceutical enterprise. What dryers belong to contact dryers? A. roll dryers B. band dryers C. air-circulation dryers D. pneumatic dryers E. nebulizing dryers 15. Different types of dryers are used in the process of preparing phyto- and or- ganopreparations. Which type of dryer is used to dry thermolabile substances? A. drum dryer B. roll dryer C. band dryer D. drying oven E. freeze dryer 16. What kind of moisture is firmly bounded to the material and does not fully retire at drying: A. equilibrium moisture B. crystalline moisture C. free moisture D. external moisture E. osmotic moisture 3 17. What devices are used for fine grinding (atomizing) of medical matters at the pharmaceutical enterprise? A. roll blenders B. disintegrators C. dismembrators D. root cutter, grass cutter E. drum mills, vibration mills 18. What kind of equipment is used for fine grinding of medical matters at the pharmaceutical enterprises? A. dezintegrator, hammer mills B. roll blender C. drum mills D. gringing mill E. vibration mills 19. Choose an equipment for moderate grinding of raw plant material: A. drum mills B. vibration mills C. root cutter and grass cutter devices D. rod mill E. jet(-type) mill 20. Devices for grinding substances are classified according to the methods of grinding. What kind of equipment the roller blender belongs to? A. rubbing machines B. abrasive machines C. percussive machines D. crushing machines E. shock centrifugal machines 21. What kind of mixers don’t have revolved details? A. drum mixers B. mixers with pseudofluidized layer C. blade mixers D. double-cone mixers E. centrifugal mixers 22. Describe the principle of operation of a jet-type mill: A. grinding of material takes place in an aerocarrier (air, rare gas), which works on a high speed B. particles of material vibrating in the self-weighted layer, concussion with bodies during grinding and abrasion C. material is grinding into a circulating frame under the action of bodies which grind D. material is grinding under the action of two centrifugal rollers which are revolved E. grinding under the action of centrifugal force 4 23. What kind of sieves can be used for sifting moist material? A. mechanical sieves B. screen grate C. many-tier shake sieves D. vibration sieves E. gyration sieves 24. What is meant under the term "bulk weight "? A. correlation of the mass of tablet to its height B. correlation of height of powder in the die to the height of tablet C. correlation of the mass to volume of freely-poured material D. correlation of the mass of tablet to its diameter E. correlation of bulk density to real density 25. Choose the correct mixer with rotation blades: A. vehicle with quasi-liquefaction of friable material B. a mixer of centrifugal action with a rotary-type frame C. worm-blade mixer D. tumbler-blender E. mixer T200 “Turbula” 26. Choose the correct mixer with rotation frame: A. ball mills B. worm-blade mixers C. vehicle with quasi-liquefaction layer D. dismembrators E. rotory- pulsation apparatus 27. A pharmaceutical enterprise buys equipment for sifting of friable materials. According to UP XI, linens for sieves must be made of: A. kapron, cotton, gauze, unbleached calico B. fabric net with square holes, latticed linens, silk fabrics C. fabric net with square holes, gauze, kapron fabrics D. copper wire, latticed linens , silk fabrics , kapron E. kapron fabrics, gauze, unbleached calico 28. Different equipment is used by the pharmaceutical enterprises in the produc- tion of solutions. What vehicles are used for mechanical mixing of liquids? A. reactors B. pulsator C. blade mixers, anchor mixers, turbine mixers D. liquid whistles E. pump 5 29. While using the acoustic interfusion a hard phase is grinding for account of: A. initiation of the phenomenon of cavitation B. turbulent flow of liquid C. electrodialysis D. high-voltage discharge E. electroplasmolysis 30. Choose the convective dryers: A. dryer with quasi-liquefaction layer , vacuum drying oven (cupboard) B. vacuum drying oven , roller vacuum-dryer, dryer with infra-red rays C. air-circulation dryers, band dryers, two rollers freeze-dryer D. chamber-type, tunnel, band, drum, aerofountain, dryer with quasi- liquefaction layer , nebulizing dryer E. high-frequency dryer, freeze- dryer, chamber, tunnel dryer, drum dryer 31. Different apparatuses are used for filtration of solutions. What filters are used for vacuum filtration? A. centrifuges B. druk filters C. frame filters-presses D. bag filters E. nutsch filters 32. On the technological stage "Precondition of water" during the production of liquid medicinal preparations utillize a different equipment for the water purified obtaining. What is the main principle of work of three-stage horizontal aqueous-distiller? A. on pumping out the steam by compressor from steam space with a next compres- sion B. steam, formed in one section is used for heating of next section C. on the coercible of repeated steam with the next entering to condenser D. on creation of rarefaction 0,88 atm, simmer of water in pipes at the temperature 96-100°С E. on boiling the water in pipes at the temperature 100°С 33. On the technological stage “Precondition of water” in the production of solutions for injections utillize a different equipment for water for injections obtaining. What is the main principle of work of thermocompression aqueous- distiller? A. creation of rarefaction 0,88 atm, simmer of water in pipes at the temperature 96- 100С B. steam, formed in one section is used for heating of next section C. pumping out the steam by compressor from steam space with a next compression D. steam distillation, that formes the boiling water E. deleting the steam from the surface of membranes in the stream of rare gas 6 34. Choose the principle of work of the industrial apparatus for obtaining the wa- ter for injections: A. revers osmosis B. distillation C. ultrafiltration D. dialysis E.