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Appendix 2 Co-Investigators Name Location Role Contribution Patrizia Accorsi ASST Spedali Civili of Brescia, Italy Site Investi

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Appendix 2 Co-Investigators Name Location Role Contribution Patrizia Accorsi ASST Spedali Civili of Brescia, Italy Site Investi Appendix 2 Co-investigators Name Location Role Contribution ASST Spedali Civili of Site Participant Patrizia Accorsi Brescia, Italy investigator recruitment/follow-up "V. Buzzi" Children's Site Participant Enrico Alfei Hospital, University of Milan, investigator recruitment/follow-up Italy Meyer Children's University Site Participant Elena Andreucci Hospital, Florence, Italy investigator recruitment/follow-up Fondazione IRCCS Ca' Gianluigi Site Participant Granda, Ospedale Maggiore Ardissino investigator recruitment/follow-up Policlinico, Milan, Italy Oasi Research Institute- Site Participant Emanuela Avola IRCCS, Troina, Italy investigator recruitment/follow-up University of Catania; CNR, Site Participant Rita Barone Catania, Italy investigator recruitment/follow-up Francesco Regional Hospital of Bolzano, Site Participant Benedicenti Italy investigator recruitment/follow-up University Hospital of Ferrara, Site Participant Stefania Bigoni Italy investigator recruitment/follow-up Microcitemie Regional Loredana Site Participant Hospital, Brotzu Hospital, Boccone investigator recruitment/follow-up Cagliari IRCCS Istituto Auxologico Site Participant Maria T. Bonati Italiano, Milan, Italy investigator recruitment/follow-up "V. Buzzi" Children's Site Participant Stefania Bova Hospital, University of Milan, investigator recruitment/follow-up2 Italy Marilena Site Participant University of Messina, Italy Briguglio investigator recruitment/follow-up Site Participant Silvana Briuglia University of Messina, Italy investigator recruitment/follow-up Site Participant Olga Calabrese ASL Imola, Italy investigator recruitment/follow-up Gaetano University Hospital Verona, Site Participant Cantalupo Italy investigator recruitment/follow-up IRCCS Istituto Giannina Site Participant Gianluca Caridi Gaslini, Genova, Italy investigator recruitment/follow-up Scientific Institute, IRCCS Site Participant Monica Cazzagon Eugenio Medea, Udine, Italy investigator recruitment/follow-up IRCCS Istituto Giannina Site Participant Maria E. Celle Gaslini, Genova, Italy investigator recruitment/follow-up University of California, San Site Participant Maria R. Cilio Francisco, CA, USA investigator recruitment/follow-up Giangennaro Site Participant University of Salerno, Italy Coppola investigator recruitment/follow-up IRCCS Bambino Gesù Site Participant Adele D’Amico Children’s Hospital, Rome, investigator recruitment/follow-up Italy IRCCS Foundation, Carlo Site Participant Stefano D’Arrigo Besta Neurological Institute, investigator recruitment/follow-up Milan, Italy AORN Santobono Pausilipon, Site Participant Daniele De Brasi Naples, Italy investigator recruitment/follow-up Maria Fulvia de AORN Santobono Pausilipon, Site Participant Leva Naples, Italy investigator recruitment/follow-up Ennio Del Federico II University, Naples, Site Participant Giudice Italy investigator recruitment/follow-up Marilena AOR Ospedale "San Carlo", Site Participant Carmela Di Potenza, Italy investigator recruitment/follow-up Giacomo Maria Lucia Di Sapienza University of Rome, Site Participant Sabato Italy investigator recruitment/follow-up IRCCS Bambino Gesù Bruno Site Participant Children’s Hospital, Rome, Dallapiccola investigator recruitment/follow-up Italy Raffaella IRCCS "Burlo Garofolo", Site Participant Devescovi Trieste, Italy investigator recruitment/follow-up IRCCS Bambino Gesù Maria Cristina Site Participant Children’s Hospital, Rome, Digilio investigator recruitment/follow-up Italy Site Participant Ilaria Donati AUSL, Cesena, Italy investigator recruitment/follow-up Meyer Children's Hospital, Site Participant Maria A. Donati Florence, Italy investigator recruitment/follow-up Site Participant Maria T. Dotti University of Siena, Italy investigator recruitment/follow-up IRCCS Bambino Gesù Site Participant Francesco Emma Children’s Hospital, Rome, investigator recruitment/follow-up Italy Antonella IRCCS "Burlo Garofolo", Site Participant Fabretto Trieste, Italy investigator recruitment/follow-up ASST Spedali Civili of Site Participant Elisa Fazzi Brescia; University of Brescia, investigator recruitment/follow-up Italy Alessandra Site Participant University of Ferrara, Italy; Ferlini investigator recruitment/follow-up Alessandro San Camillo-Forlanini Site Participant Ferraris Hospital, Rome, Italy investigator recruitment/follow-up Giovanni Battista Site Participant University of Torino, Italy Ferrero investigator recruitment/follow-up Polytechnic University of Site Participant Anna Ficcadenti Marche, Ospedali Riuniti, investigator recruitment/follow-up Ancona, Italy IRCCS, Stella Maris Site Participant Simona Fiori Foundation, Pisa, Italy investigator recruitment/follow-up Giovanni XXIII Children's Site Participant Rita Fischetto Hospital, Bari, Italy investigator recruitment/follow-up IRCCS Foundation, Carlo Site Participant Elena Freri Besta Neurological Institute, investigator recruitment/follow-up Milan, Italy AUSL-IRCCS of Reggio Site Participant Livia Garavelli Emilia, Reggio Emilia, Italy investigator recruitment/follow-up Di Venere Hospital, Site Participant Mattia Gentile Carbonara, Bari, Italy investigator recruitment/follow-up ASST Spedali Civili of Site Participant Lucio Giordano Brescia, Italy investigator recruitment/follow-up Oasi Research Institute- Site Participant Donatella Greco IRCCS, Troina, Italy investigator recruitment/follow-up ASST Spedali Civili of Site Participant Claudia Izzi Brescia, Italy investigator recruitment/follow-up Sapienza University of Rome, Site Participant Vincenzo Leuzzi Italy investigator recruitment/follow-up Elisabetta Scientific Institute IRCCS Site Participant Lucarelli Eugenio Medea, Brindisi, Italy investigator recruitment/follow-up San Camillo-Forlanini Site Participant Silvia Majore Hospital, Rome, Italy investigator recruitment/follow-up Maria M. IRCCS Istituto Giannina Site Participant Mancardi Gaslini, Genova, Italy investigator recruitment/follow-up University of Siena; AOU Site Participant Francesca Mari Senese, Siena, Italy investigator recruitment/follow-up Fondazione IRCCS Ca' Giuseppina Site Participant Granda, Ospedale Maggiore Marra investigator recruitment/follow-up Policlinico, Milan, Italy S. Orsola Malpighi University Site Participant Laura Mazzanti Hospital, Bologna; University investigator recruitment/follow-up of Bologna, Italy Federico II University, Naples, Site Participant Daniela Melis Italy investigator recruitment/follow-up Emanuele IRCCS Policlinico San Site Participant Micaglio Donato, Milan, Italy investigator recruitment/follow-up Marisol IRCCS Istituto Giannina Site Participant Mirabelli- Gaslini, Genova, Italy investigator recruitment/follow-up Badenier IRCCS Foundation, Carlo Site Participant Isabella Moroni Besta Neurological Institute, investigator recruitment/follow-up Milan, Italy IRCCS Foundation, Carlo Site Participant Nardo Nardocci Besta Neurological Institute, investigator recruitment/follow-up Milan, Italy Margherita University Hospital of Padua, Site Participant Nosadini Padua, Italy investigator recruitment/follow-up IRCCS Mondino Foundation, Site Participant Simona Orcesi Pavia, Italy investigator recruitment/follow-up University of Insubria, Varese, Site Participant Giovanni Pagani Italy investigator recruitment/follow-up IRCCS Foundation, Carlo Chiara Site Participant Besta Neurological Institute, Pantaleoni investigator recruitment/follow-up Milan, Italy Francesco Giovanni XXIII Children's Site Participant Papadia Hospital, Bari, Italy investigator recruitment/follow-up Sapienza University of Rome; Site Participant Pasquale Parisi Sant'Andrea Hospital, Rome, investigator recruitment/follow-up Italy. Maria Grazia IRCSS San Raffaele Scientific Site Participant Patricelli Institute, Milan, Italy investigator recruitment/follow-up AOU della Carità, Novara, Site Participant Cinzia Peruzzi Italy. investigator recruitment/follow-up IRCCS Istituto Giannina Site Participant Alice Pessagno Gaslini, Genova, Italy investigator recruitment/follow-up Site Participant Maria Piccione University of Palermo, Italy investigator recruitment/follow-up IRCCS Institute of Neurological Sciences, Site Participant Antonella Pini Bellaria Hospital, Bologna, investigator recruitment/follow-up Italy Meyer Children's University Site Participant Tiziana Pisano Hospital, Florence, Italy investigator recruitment/follow-up IRCCS Istituto Giannina Site Participant Livia Pisciotta Gaslini, Genoa; University of investigator recruitment/follow-up Genoa, Italy; AUSL-IRCCS, Reggio Emilia, Site Participant Marzia Pollazzon Italy investigator recruitment/follow-up Santa Chiara Hospital, Trento, Site Participant Francesca Rivieri Italy investigator recruitment/follow-up Federico II University, Naples, Site Participant Alfonso Romano Italy investigator recruitment/follow-up Oasi Research Institute- Site Participant Corrado Romano IRCCS, Troina, Italy investigator recruitment/follow-up University of Padova; Istituto Site Participant Leonardo Salviati di Ricerca Pediatrica, IRP, investigator recruitment/follow-up Padova, Italy Carmelo Site Participant Damiano University of Messina, Italy investigator recruitment/follow-up Salpietro IRCCS Institute of Margherita Neurological Sciences, Site Participant Santucci Bellaria Hospital, Bologna; investigator recruitment/follow-up University of Bologna, Italy Emanuela S. Orsola-Malpighi Hospital, Site Participant Scarano Bologna, Italy investigator recruitment/follow-up "V. Buzzi" Children's Site Participant Barbara Scelsa Hospital, University of Milan, investigator recruitment/follow-up
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