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Study Protocol
Protocol: ATI-501-AUAT-201 Aclaris Therapeutics, Inc. CLINICAL STUDY PROTOCOL A Randomized, Double-Blind, Placebo-Controlled Multicenter Study to Evaluate the Safety, Tolerability and Efficacy of ATI-501 Oral Suspension Compared to Placebo in Adult Subjects with Alopecia Areata, Alopecia Universalis or Alopecia Totalis Amendment 4 Compound: ATI-501 US IND Number: 129, 539 Protocol Number: ATI-501-AUAT-201 Phase: 2 Sponsor Medical Monitor Aclaris Therapeutics, Inc. Jeffrey Sugarman, MD, PhD 640 Lee Road Telephone: 707-545-4537 Suite 200 Facsimile: 707-545-6723 Wayne, PA 19087 [email protected] Telephone: 484-324-7933 Facsimile: 484-320-2344 Study Contact Safety Contact: Sue Moran, RN, MSN Deborah S. Kelly, M.D. Sr. Director, Clinical Development Senior Medical Director, Safety, PV & Risk Aclaris Therapeutics, Inc. Management 640 Lee Road Aclaris Therapeutics, Inc. Suite 200 640 Lee Rd Wayne, PA 19087 Suite 200 Telephone: 484-329-2129 Wayne, PA 19087 Cell: 484-999-7492 Telephone: 484-540-2262 E-mail: [email protected] Cell: 484-280-2262 Email: [email protected] ProPharma email: [email protected] This document is a privileged and confidential communication of Aclaris Therapeutics, Inc. Acceptance of this document constitutes an agreement by the recipient that no unpublished information contained herein will be used, published or disclosed without prior written approval from Aclaris Therapeutics, Inc. Date: 09APR2019, Version 5.0 Page 1 of 90 CONFIDENTAL Protocol: ATI-501-AUAT-201 Aclaris Therapeutics, Inc. INVESTIGATOR’S AGREEMENT I have received and read the Investigator’s Brochure for ATI-501. I have read the ATI-501- AUAT-201 protocol and agree to conduct the study as outlined. -
How the Experience of Cyberspace Contributes to the Emerging Story of Self in Young People
Morph Constructing identity: how the experience of cyberspace contributes to the emerging story of self in young people. Jill Lesley Clough Thesis submitted towards the degree of Doctor of Philosophy in the School of English Literature Language, and Linguistics Newcastle University April 2013 Awarded October 2013 Supervisors: Professor Linda Anderson, Professor Jackie Kay Abstract for Morph. Constructing identity: how the experience of cyberspace contributes to the emerging story of self in young people. This thesis develops from the belief that young people construct identities for themselves which inevitably surprise their parents, particularly where so much of their coming-of-age is influenced by hidden virtual experiences. The novel which explores this is Morph. Joey, the protagonist, is uneasy about her gender. She has a loving family, intelligence, a satisfying way of life, but loathes her body. She investigates alternative futures, initially online. Her closest friend also has a secret, revealed after a suicide attempt that Joey averts: sexual abuse by her father. Each has to discover how to live with the evolving sense of self. If Joey wishes to change gender her character may alter, too; she finds she can be violent when confronting the abusive father. The story is told through Joey’s eyes and activities in cyberspace, which she thinks of as a free place, parallel to the mountains over which she loves to run. She feels at ease in both places. Eventually she decides to live as both male and female (Other) because she does not have a ‘condition’ needing to be cured. Classification in the natural world allows for infinite variety, and she want similar opportunities for herself. -
I's the Merb'y: Masculinity, Mermen and Contemporary Newfoundland
I’S THE MERB’Y Masculinity, Mermen and Contemporary Newfoundland [Received 22nd April 2018; accepted 29th July 2018 – DOI: 10.21463/shima.12.2.17] Philip Hayward University of Technology Sydney <[email protected]> Cory W. Thorne Memorial University of Newfoundland <[email protected]> ABSTRACT: In late 2017 initial, low-key publicity for a charity calendar featuring a range of bearded Newfoundlanders posing as mermen resulted in international media coverage that discussed and commended the non-stereotypical images produced for the project. This article situates the calendar’s imagery within the history of regional folklore concerning mermen and mermaids, the socio-cultural character of the island of Newfoundland and, in particular, the milieu of its port capital, St. John’s. Through these perspectives, the article analyses aspects of masculinity present in an island society that has experienced significant transitions in recent decades in relation to the decline of its fishery, the increasing work- related mobility of former fisherpeople, increasing ethnic diversity and immigration, and the breaking down of once strongly held attitudes of Newfoundland as being isolated, homogenous and tradition-based. In terms of Island Studies discourse, this has involved the island’s transition from being a relatively autonomous aquapelagic assemblage to an increasingly post-aquapelagic one firmly incorporated within a nation-state. Long viewed as a quintessential “folk setting”, Newfoundland is in a state of change that includes the gradual modification of regional stereotypes of masculinity. The revised images and roles presented in the calendar can be seen to represent new, more fluid definitions of masculinity appropriate for an increasingly more cosmopolitan — yet proudly unique — island society. -
Rhinologic Signs Associated with Snuff Taking
European Annals of Otorhinolaryngology, Head and Neck diseases 137 (2020) 43–45 Available online at ScienceDirect www.sciencedirect.com Original article Rhinologic signs associated with snuff taking a,∗ a a b S.H.R. Hounkpatin , M.C. Flatin , A.F. Bouraima , H.N. Amegan , a b M.A.F. Toukourou Adios , W. Adjibabi a Faculté de médecine de l’Université de Parakou, Parakou, Benin b Faculté des sciences de la Santé de l’Université d’Abomey-Calavi, Cotonou, Benin a r t i c l e i n f o a b s t r a c t Keywords: Objective: To study rhinologic signs associated with nasal tobacco (snuff) intake in Parakou, northern Tobacco Benin. Nasal intake Materials and methods: A cross-sectional descriptive comparative study included 300 tobacco snuff takers Chronic rhinitis and 300 subjects who did not use tobacco at all. The sampling technique was a stratified 4-stage random Snoring sample for non-users and a convenience non-random sample for snuff takers. Hyposmia Results: The sex-ratio was 0.92 in non-users and 41.9 in snuff takers. Duration of snuff taking was more than 20 years in 24.3% of cases. The symptoms studied were significantly more frequent in snuff tak- ers than non-users (P < 0.05). Snoring was reported by 58.3% of snuff takers, versus 5.7% of non-users (P = 0.000). Nasal obstruction and rhinorrhea were reported by respectively 26.3% and 22.7% of snuff tak- ers, versus 6.3% and 5.3% of non-users (P = 0.000). -
THE I-STUBBLEPRO TOOL TIPS Ultimate Precision Shorter Beard & Designer Stubble Trimmer
THE i-STUBBLEPRO TOOL TIPS ultimate precision shorter beard & designer stubble trimmer. VSM7896A HEY YOU! TAKE A BOW FINE SIR. THINGS ARE LOOKING UP & YOU’VE JUST MADE A QUALITY PURCHASE WITH THIS NEW GROOMING TOOL. WE KNOW YOU’VE GOT THIS, BUT BEFORE YOU JUMP INTO USING YOUR NEW SIDE KICK, HERE’S A FEW TIPS & TRICKS TO KNOW BEFORE LETTING YOUR CREATIVITY RUN LOOSE. HIT UP VSFORMEN.COM.AU FOR MORE GROOMING & INSPIRATION OR FOLLOW US ONLINE 2 THE i-STUBBLE PRO / TOOL TIPS 3 THE i-STUBBLE PRO / TOOL TIPS IMPORTANT SAFETY INSTRUCTIONS - This appliance is not intended for use by persons (including children) with reduced physical, sensory or mental capabilities, or lack of experience and knowledge, unless they have been given supervision or instruction concerning use of the appliance by a person responsible for their safety. - Children should be supervised to ensure that they do not play with the appliance. - This appliance is only to be used with the power supply unit provided with the appliance. - This appliance must only be supplied at safety extra low voltage corresponding to the marking on the appliance. When using electrical appliances, especially when children are present, basic safety instructions should always be followed, including the following: Polythene bags over product or package may be dangerous. To avoid danger of suffocation, keep this wrapper away from babies and children. This bag is not a toy. DANGER: When the unit is used in a bathroom, unplug it after use since the proximity of water presents a hazard even when the appliance is switched off WARNING: Do not use or leave the AC power adaptor in a position where it can become wet or there is a danger of it falling into a basin or other vessels containing water. -
Eyebrow Transplant
Case Report J Cosmet Med 2020;4(1):46-50 https://doi.org/10.25056/JCM.2020.4.1.46 pISSN 2508-8831, eISSN 2586-0585 Eyebrow transplant Viroj Vong, MD H.H.H. Hair Transplant Center, Bangkok, Thailand Eyebrow compose of very unique characteristics hair. Only hair from lower nape of occipital scalp or very light pubic hair can match loosely as donor hair. Blonde hair or light color hair give better result. Black Asian hair is more difficult because of the contrast between skin and hair. Design eyebrow follow natural pattern, gender, direction within normal variation is very important to make it look natural. Donor hair can be done by 2 methods. Common one is H.H.H. FUE. FUE is done by extract each unit of hair follicle out from occipital scalp then transplant to eyebrow. Second is Strip harvesting by remove a piece of occipital scalp divide to follicular unit. Then transplant this unit to eyebrow. FUE produce no scar at the occipital scalp (Donor site). Strip harvesting produce a linear scar at the donor site (occipital scalp). Keywords: eyebrow; hair transplant Introduction tion and blood test. He consulted his gastrointestinal specialist in Britain, who confirmed that he was safe to undergo hair The patient was white, male, and 75 years old. He was not transplantation. His vital signs and blood test results for human happy with his eyebrows and thought they were too thin. He immunodeficiency virus (HIV), bleeding time, and coagulation recovered from Crohn’s disease of his colon. At the time of the time were all within their normal limits. -
A Critical Study of Transsexual Transition in a Familial Context
1 Straddling the scalpel of identity: a critical study of transsexual transition in a familial context Claire Elizabeth Jenkins Doctor of Philosophy Sociological Studies December 2012 2 Acknowledgements Many have helped me. Firstly I would like to thank my immediate family, my ex-wife and my four children, for sharing in my transition which was the genesis of this research. I very much appreciate the invaluable help given by Dr Emily Gray in formulating my original research proposal. Perlin Dobson and David Jackson, my dear friends, have consistently supported me through transition to submission. David read many of my drafts and gave me critical feedback. Perlin gave emotional support when times were difficult. I am very appreciative of the invaluable advice and support given by Kevin Mahoney of Sheffield University Careers Service. These friends together with Nirmal Fernando, David Jones, Professor Stephen Whittle, Dr Roshan das Nair, Jayne Tulip and Imogen Hale were especially helpful when I experienced a major setback. They helped me to re-continue afterwards. I would also like to more formally thank my supervisors, Dr Victoria Robinson, Dr Lorna Warren and Professor Jenny Hockey, who taught me much about sociological writing and thought and who gave extensive critical feedback. Dr Warren has especially helped me regain academic confidence during 2012. I am also grateful for the informed critiques received from Professor Ruth McDonald, Professor Brendan Gough and David Miers. I am especially grateful to Brenda Stephenson and Dawn Montiel for the proof reading early drafts. I would also like to thank Duncan Macmillan House Staff Library and Nottingham Trent University Library Staff for supporting me locally through book acquisition, loans and for obtaining journal articles. -
The Art of a Beard
The Art Of A Beard From designer stubble to a full grown man, it’s clear to see that the beard is becoming more standard procedure than the sign of being homeless in recent years. With celebrities such as Johnny Depp, Brad Pitt and David Beckham sporting facial fur it’s become an unwritten rule that a fashionable man cannot be without a beard. With dedicated websites to the beard that include step by step guides to growing a beard, featured beards and beard galleries, the modern man has all the information he needs at his fingertips to shape colour or groom his beard into any style he wants. So how comes beards are seen as more of a fashion statement than just pure laziness? Do us gents perceive the beard as a manly statement rather than a result of being scruffy? Whether you like the beard of not, it’s become more and more acceptable to have a beard in the office. In fact, it has been said that the vast majority of men now sport beards, and that it’s moved from sticking out like a sore thumb with a beard to looking out of place if you don’t have a beard. There’s even a sponsored facial hair growing month. ‘During November each year, Movember is responsible for the sprouting of moustaches on thousands of men’s faces in the UK and around the world. The aim of which is to raise vital funds and awareness for men’s health, specifically prostate cancer and other cancers that affect men.’ Says Movember.com. -
Arbor House Branch Arbor House Assisted Living & Memory Care 9240 E
November 2019 Arbor House Assisted Living Postage Information & Memory 9240 E. Reno Midwest City, OK 73130 Arbor House Branch Arbor House Assisted Living & Memory Care 9240 E. Reno, Midwest City, OK 73130 (405) 455-3900 ph. (405)610-6937 fax Bread for Breaking and Baking This November, there are a variety of holidays that encourage the gathering of families and friends: Día de Muertos in Mexico, Diwali in India, Thanksgiving in the United States, Saint Andrew’s Day in Scotland, and many Celebrating November others. These holidays offer the perfect opportunity to Birthdays: “break bread” with loved ones. While many will literally be breaking bread at their feast tables, the expression Barbara Phillips 11/13 “break bread together” denotes sharing more than just food, but also feelings of love, trust, and togetherness. Dusty Chambless 11/11 Clara Lee Winders 11/20 Many believe that the phrase “breaking bread” originated Calvin Baker 11/24 in the New Testament of the Bible, where Jesus broke bread and shared it with his apostles during the Last Supper. It was this Scriptural sharing of bread that provides Staff: the basis for the Eucharist, or “Holy Communion.” However, Abel Hernandez 11/5 the ritual breaking of bread dates back to before the Last Supper and has a long Jewish history, a history with which Anna Hernandez 11/5 Japan’s Movie Monster November Birthdays Jesus, as a Jew, was familiar. The Jewish ritual of Shabbat Misty Birdsong 11/6 On November 3, 1954, the In astrology, those born November 1–22 Sondra Myers 11/6 involves breaking bread. -
Ghosh Calcutta Chromosome.Pdf
PUBLISHED BY ALFRED A. KNOPF CANADA Copyright © 1995 by Amitav Ghosh All rights reserved under International and Pan-American Copyright Conventions. Published in Canada by Alfred A. Knopf Canada, Toronto, and simultaneously in Great Britain by Picador, an imprint of Macmillan publishers Ltd, London, in 1996. First published in 1995 by Ravi Dayal Publisher, New Delhi. Distributed by Random House of Canada Limited, Toronto. Canadian Cataloguing in Publication Data Ghosh, Amitav The Calcutta chromosome: a novel of fevers, delirium and discovery ISBN ()-3~)4-28193-4 1. Title PR9499.3.G536C35 1996 823 C96-930491-9 First Canadian Edition Type-set hy CentraCct Limited, Cambridge l'rinu-d hy Mackuys of Chatham, pic, Chatham, Kent For Koeli This day relenting God Hath placed within my hand A wondrous thing; and God Be praised. At His command, Seeking His secret deeds With tears and toiling breath, I find thy cunning seeds, O million-murdering Death. Sir Ronald Ross (Nobel Prize for Medicine, 1902) AUGUST 20: MOSQUITO DAY Chapter 1 IF THE SYSTEM hadn't stalled Antar would never have guessed that the scrap of paper on his screen was the remnant of an ID card. It looked as though it had been rescued from a fire: its plastic laminate had warped and melted along the edges. The lettering was mostly illegible and the photograph had vanished under a smudge of soot. But a four-inch metal chain had somehow stayed attached: it hung down in a rusty loop from a perforation in the top left-hand corner, like a drooping tail. -
Zero Complaints – the Ultimate Goal for Hair Contamination Is Attainable
Zero complaints – the ultimate goal for hair contamination is attainable by Richard Burnet, ABurnet Ltd, pendently reviewed by Professor severance of hair-shafts that will be Walter Street, Draycott, Barry Stevens MA FTTS, President found to contaminate food and Derbyshire DE72 3NU, UK. of the Trichological Society 2014-16. therefore need to be effectively con - The research discovered a wide tained. hen big food retailers dis - range of factors that influence the Professor Stevens adds: “If we cover hair contamination rate of hair loss; natural and envi - accept that hair-shaft shedding is a Wthey fine the food and ronmental factors that can reduce constant occurrence it is possible drink manufacturers who make the the effectiveness of some head cov - that 13-43 hairs could be shed from store’s own-label products. They ering and causes of workers discom - the scalp of each employee during even de-list the very worst offend - fort that can significantly boost the an eight hour period. This equates ers. It is a big incentive to manufac - numbers of hairs that they shed. with 1,300-4,300 hairs per 100 peo - turers to work harder to reduce the ABurnet developed products and ple. numbers of complaints, but it is a methods of covering as the research “These figures can be significantly complicated challenge. progressed and trials with close augmented by thermal injury and A food production worker can assessment of the test candidates severance (following exposure to boast of having between 100,000 to produced hundreds of pieces of data KleenCap NeckGuard with excessive heat from hairdryers, curl - 145,000 scalp hair-shafts at any that demonstrated the most effec - StayCool and antimicrobial ing tongs etc) and chemical insult given time. -
A Brief Description of the Characters in Rick Riordan Novel”The Battle of the Labyrinth”
A BRIEF DESCRIPTION OF THE CHARACTERS IN RICK RIORDAN NOVEL”THE BATTLE OF THE LABYRINTH” A PAPER WRITTEN BY OPRILTA GINTING REG. NO: 132202030 DIPLOMA-III ENGLISH STUDY PROGRAM FACULTY OF CULTURE STUDY UNIVERSITY OF NORTH SUMATERA MEDAN 2016 UNIVERSITAS SUMATERA UTARA It has been proved by Supervisor, Drs. SiamirMarulafau, M.Hum NIP: 19580517198503 1 003 Submitted to Faculty of Cultural Study, University of Sumatera Utara in partial fulfillment of the requirements for Diploma-III in English Study Program Approved, Head of English Diploma Study Program, Dr. Matius C.A Sembiring, M.A. NIP: 19521126198112 1 001 Approved by the Diploma-III of English Study Program Faculty of Cultural Study, University of Sumatera as a Paper for the Diploma-III Examination. Accepted by the Board of Examiner in partial of the requirements for the D-III Examination of the Diploma-III of English Program, Faculty of Culture Study, University of Sumatera Utara. UNIVERSITAS SUMATERA UTARA The Examination is held on June 2016 Faculty of Cultural Study University of Sumatera Utara Dr. SyahronLubis, M.A. NIP: 19511013197603 1 001 Board of Examiner: 1. Dr. Matius C.A. Sembiring, M.A. (Head of ESP) 2. Drs. Siamirmarulafau, M.A. (Supervisor) 3. Dr. Matius C.A. Sembiring, M.A (reader) UNIVERSITAS SUMATERA UTARA AUTHOR DECLARATION I, OPRILTA GINTING, declare that I am the sole author of this paper. Except where the reference is made in the next to this paper, this paper contains no material published elsewhere or extracted in whole or in part from a paper by which I have qualified or awarded another degree.