DOCERE US Cannabis Regulation: What It NATUROPATHIC DOCTOR NEWS & REVIEW Means for Naturopathic Doctors ...... >>10 VOLUME 15 ISSUE 1 JANUARY 2019 | GASTROINTESTINAL HEALTH / TOXICOLOGY / BARIATRIC Shaon Hines, ND Laws around marijuana and hemp are confusing. Dr Hines’ article helps to clarify the issues.
FUT2 Secretor Status: Tolle Totum Effects on Gut Health ...... >>16 Ginger Nash, ND The gene controlling secretion of ABO antigens into Prebiotics & bodily fluids highly impacts GI function. EDUCATION Medical Resources for NDs: Metabolic Regulation A Review of Current Publications for the Naturopathic Industry ...... >>13 Blaine Harbourne, ND, LDN, CNS, CSCS Benefits Beyond the Gut Dr Morstein’s book on diabetes is a valuable resource for both patients and practitioners.
Naturopathic Medical Education: ERICK R. CERVANTES, MPH, ND What a Russian Soldier Taught Me DALE PFOST, PHD About Its Value Proposition ...... >>28 David J. Schleich, PhD uman beings are host to a diverse Weaving traditional values into worrying trends will keep the medicine defined in tough terrain. Hecosystem known as the microbiome. Characteristic of our microbiome, among many other things, is its now well-known TOLLE CAUSAM diversity within the individual and from Autoimmunity & GI Disorders: person to person, as well as its vast array Sorting Out the Triggers ...... >>14 of elaborate influences on our physiology. Chad Larson, NMD, DC, CCN, CSCS Dr Larson reviews models of immune dysregulation Our scientific knowledge of this symbiotic and how to nail responsible triggers. ecosystem has grown tremendously, and its clinical significance and implications cannot Clostridia & Constipation: Using Organic Acid Testing in be ignored. This paper highlights how some Diagnosis & Treatment ...... >>18 microbiota within our intestinal tract, in Angela Knapp, ND particular the large intestine, influences Dr Knapp reviews an often overlooked cause of chronic constipation and how to identify it. Continued on page 3 NATUROPATHIC Student Scholarship Honorable Mention PERSPECTIVE SIBO as an Adaptation: A Proposed Role for Hydrogen Sulfide ...... >>20 Greg Nigh, ND, LAc Psychiatric Disorders Despite symptom-inducing, microbial H S might be 2 Targeting the Microbiome an important source of sulfate in the body. STUDENT SCHOLARSHIP Honorable Mention – The Carroll ALEXANDRA FRANCIS, ND, MS, CNS genes than the human genome. It is now bowel syndrome (IBS) and inflammatory Method: An Explanation ...... >>22 MARIE WINTERS, ND, FABNO widely considered that the gut microbiota bowel disease (IBD), as well as systemic Jared C. Pistoia should be considered an ‘exteriorized’ conditions such as diabetes mellitus, obesity, Sussanna Czeranko, ND, BBE All disease begins in the gut. organ placed within the body, which and cardiovascular disease. This bioelectric technique for identifying food intolerances is far underutilized by doctors. (Hippocrates) provides important physiological functions 1 and is indispensable for human life.” Psychiatric Disorders VIS MEDICATRIX NATURAE hen in doubt, treat the gut” is These microorganisms are responsible for About half of US adults will experience Wan excellent naturopathic rule of metabolizing dietary nutrients, xenobiotics, a mood or mental disorder consistent Gallbladder Disease: thumb that naturopathic doctors have and drugs, as well as maintaining the with the diagnostic criteria in the DSM- Not Just a Problem for Women...... >>24 Robin DiPasquale, ND, RH (AHG) relied on for decades. We have always integrity of the gut mucosal barrier, IV at some point during their lives.3 Dr DiPasquale reviews risk factors and treatment understood that symptoms and chronic immunomodulation, and protection The onset of these disorders is usually tips for gallbladder, including key herbs. diseases often improve when we focus against pathogens.2 during childhood or adolescence, which on treating the gut, but only recently has Our knowledge of the functions and suggests that treatment methods should NATURE CURE there been exploration into why this is roles the gut microbiome plays in our be directed at the younger population and so. We’ve been told that we have more health and physiology has been expanding. emphasize prevention.3 Use of conventional CLINICAL PEARLS microorganisms in our gut (meaning our The gut microbiome is a relatively new drug therapies for psychiatric disorders Dyspepsia ...... >>26 whole digestive system, but primarily exploration in the field of medicine, and has been on the rise over the last few Sussanna Czeranko, ND, BBE the small and large intestines) than we recent research has shed light on promising decades. Given the increasing rates of A century ago, Naturopaths were already successfully treating dyspepsia naturally. have cells comprising our bodies. “The new clinical applications of focusing mood disorders and drug dependence human gut microbiota consists of a treatment efforts on the gut microbiome. trends, conventional drug therapy appears NDNR.COM complex community exceeding 100 trillion Some of the conditions shown to benefit to have had relatively low efficacy in Register online to read web-only content and microorganisms whose collective genome from optimizing the gut microbiome include psychiatric patients, especially those with access archives. – the microbiome – encodes 100 times more several digestive disorders, such as irritable Continued on page 8 Available online at ndnr.com
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Continued from top of page 1 our health through its fermentation of dramatic effects on the composition of the prebiotic dietary fiber and polyphenols microbiota and consequently the type and and the resulting metabolite-driven amount of SCFAs produced. feedback mechanisms. In addition, this The health of our GI tract and the paper discusses the clinical implications of health of our microbiota are thus directly prebiotic (dietary fiber and polyphenols) correlated to our dietary intake of fiber. Our Western lifestyle plays a detrimental role in supplementation for various metabolic More specifically, daily intake of dietary syndromes in terms of its influence on prebiotics (polyphenols and non-digestible our health and well-being. Characteristic of a satiety and blood glucose regulation. complex carbohydrates, aka fiber) directly To illustrate, we present findings from affects the diversity of our microbiota, Standard American Diet (SAD) and Western 2 clinical studies examining the health our metabolism, and therefore our health. effects of a prebiotic blend referred to as a Prebiotics cannot be digested by humans lifestyle is a sedentary lifestyle and an increase Gastrointestinal Microbiome Modulator, or but are fermentable and serve as nutrients GIMM. Both studies were conducted under for the microbiota in the large intestine. the direction of Frank Greenway, MD, of the The SCFAs (the products of fermentation) in energy intake in the form of increased dietary Pennington Biomedical Research Center in are used by the cecal and colonic Baton Rouge, LA, one of the nation’s leading epithelium cells for energy production, and sugars and processed foods. centers for nutrition research. they lower luminal pH, which inhibits the In general, our Western lifestyle plays growth of pathogenic bacteria. a detrimental role in our health and SCFAs also have far-reaching actions well-being. Characteristic of a Standard beyond the intestine. For example, SCFAs American Diet (SAD) and Western lifestyle is a decrease in physical exercise (sedentary lifestyle) as well as an increase in energy intake in the form of increased dietary sugars and processed foods.1 Such diets have a high glycemic index, are high in calories, and contribute to both high blood sugar excursions and weight gain. Daily consumption of this type of diet has led to an increased incidence of complex symptoms collectively categorized as metabolic syndrome. The key characteristics of metabolic syndrome are obesity, loss of glycemic control, dyslipidemia, and hypertension.1 The relationship of these conditions with gut health and our microbiota is explained here. It is also important to note that associated luminal dysbiosis due to poor dietary choices and other factors – such as food sensitivities/allergies, exposure to pesticides in our food supply, alcohol abuse, and antibiotics – plays a major role in gut permeability and impaired gut-barrier function.2 The consequences are a variety of other associated clinical conditions: food sensitivities and allergies, allergic rhinitis, inflammatory bowel disease, celiac disease, autoimmune hepatitis, prediabetes, type 2 diabetes mellitus, multiple sclerosis, systemic lupus erythematosus, depression, and autism.
Prebiotics, SCFAs & Health Our gastrointestinal (GI) health is greatly dependent not only on the foods we eat, but also on the health of our gut microbiota. The human microbiome is the entirety of the environment of microorganisms living in and on our bodies.3 The majority of them symbiotically inhabit our GI tract. Diets that are high in fruit and vegetables are richer in fiber than the SAD diet. On average, Western diets provide approximately 20-25 grams of dietary fiber per day, while high fruit and vegetable diets provide approximately 60 grams of dietary fiber.1 Intestinal bacteria, specifically those residing in the cecum and large intestine, produce short-chain fatty acids (SCFAs) – key signaling metabolites from non-digestible nutrients, specifically fiber and polyphenols, that pass out of the small intestine unaffected.1 The major types of fiber that pass through the gut are plant cell-wall polysaccharides, oligosaccharides, and resistant starches (eg, inulin and beta-glucan). The relationship between the health of our microbiota and high-fiber diets has been well established. Interestingly, the amount and type of fiber consumed has NATUROPATHIC DOCTOR NEWS & REVIEW JANUARY 2019 3 AD FORM MUST BE COMPLETED IN FULL
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act as signaling molecules to G-protein the pancreas for glucose regulation; it also fungi (as determined by DNA analysis); expands the microbiota populations, receptors involved in satiety and glucose slows gastric emptying.4-7 SCFAs; markers for digestion, absorption, leading to an increased production of regulation, and they regulate the balance and inflammation; and secretory IgA SCFAs (Figure 1).14 With the growth between fatty acid synthesis, fatty acid Study #1 (sIgA) to assess immune function. This achieved by inulin, the second ingredient oxidation, and lipolysis. Specifically, fatty Prebiotic Effects on GI Microbes prebiotic blend was specifically designed – polyphenols extracted from blueberries acid oxidation is activated by SCFAs in & SCFAs to produce a greater yield of SFCAs in the – serves as a microbial substrate that is the liver and muscle tissue, while de novo In a placebo-controlled, double-blind large intestine by diverting biosynthetic acetogenic, ie, uses hydrogen to produce synthesis and lipolysis are inhibited. This randomized trial, 30 adults with a body pathways towards the SCFAs and shifting acetate, a key SCFA (Figure 2).15,16 This can results in a reduction of free fatty acids in mass index (BMI) >30 or a diagnosis of away from biosynthesis of methane and result in a competitive advantage for the the plasma and a decrease in body weight.1 prediabetes were administered either a hydrogen sulfide, gases that have been acetogens and helps shift the microbiome SCFAs inhibit fat storage in adipose prebiotic formulation or placebo for 4 associated with obesity,9,10 type 2 diabetes,11 activity from microbiota that would tissue by suppressing insulin signaling weeks. Stool and blood samples were irritable bowel syndrome and colitis.12,13 otherwise produce methane and hydrogen in adipocytes, while promoting lipid and collected at baseline and at 4 weeks, and The blend included inulin, beta-glucan, sulfide. The third ingredient, beta-glucan, glucose metabolism in other tissues.1 markers for intestinal microbiome health and polyphenols, totaling 8.8 grams of fiber protects the GI tract by triggering the Moreover, SCFAs trigger the release of gut and metabolic parameters were measured. in powdered form. A blend of xanthan gum release of sIgA and acting as a decoy hormones, peptide YY (PYY) and glucagon- For the GI portion of the study, a and cellulose was used for the placebo. substrate for microbiota to consume instead like peptide-1 (GLP1). PYY is known as a GIMM, a strategic blend of 3 prebiotic Participants were instructed to mix the of digesting the mucosal lining.15,17-21 satiety hormone, helping to promote the nutrients, was studied for its ability powder into 6 oz water and take it twice feeling of satisfaction and early cessation of to promote a healthy-functioning gut daily on an empty stomach. No changes Summary of Prebiotic Blend eating. GLP1 triggers the release of insulin microbiome.8 Fecal assessments included were made to their daily meal routine. • Inulin from agave promotes growth and decreases the secretion of glucagon by aerobic and anaerobic bacteria and yeast/ Inulin is a fermentable prebiotic that of microbial populations that produce SCFAs • Polyphenol antioxidants from blueberries provide a substrate for the growth and activity of certain MITOCHONDRIA microbiota that produce acetate, a key SCFA • Beta-glucan from oats protects the intestine’s mucosal lining and supports the immune system Integrative Solutions Prebiotic Effects on Glucose Regulation & Appetite This same study8 also assessed the X Mitochondrial Support effectiveness of GIMM on metabolic parameters, lipids, and satiety, at baseline and at 4 weeks. Evidence supports the X Cytokine Support significant role of the gut microbiota in N Phospholipid membrane repair* the biochemistry of satiety – the feeling of reduced hunger and desire for smaller X Antioxidant—Nrf-2 Support N Krebs cycle support* portions at mealtime.22 A validated Visual Analog Scale (VAS) was utilized to assess N Clinically researched satiety. Blood measurements included X Detox Support serum glucose and insulin (in a 3-hour oral glucose tolerance test [GTT]), hemoglobin CYTOKINE SUPPORT A1c, hs-C-reactive protein (hsCRP), PYY, ghrelin, lipids, and other blood chemistry. Compared to placebo, results for the prebiotic group showed reduced mealtime blood glucose measurements, as measured during the oral GTT (Figure Tel: 805.693.1802 • Fax: 805.693.1806 • [email protected] 3); increased satiety, as measured by www.ResearchedNutritionals.com | Available only through healthcare professionals the VAS (Figure 4); and increased levels of sIgA, a fecal biomarker for immune preparedness (Figure 5). ANTIOXIDANT Study #2 Effect of Prebiotics on DETOX Metformin Tolerability N Promotes healthy Not all drugs developed to be taken orally cytokine activity* are completely absorbed into the blood N Highly absorbable and thus remain in the GI tract where there is potential for interactions with the polyphenol blend* microbiota. Individuals with high blood N Nrf-2 support* sugar are commonly offered metformin, an effective glucose-lowering therapeutic that is generally well tolerated; however, the drug can occasionally lead to diarrhea, N Targets hydroxyl radical group* constipation, heartburn, or nausea. For some people, this is enough to make it a challenge N Crosses blood-brain barrier & cell for them to achieve the recommended membrane* dosing. This second study showed that the N Clinically researched same prebiotic blend (GIMM) provides N Nrf-2 support, which promotes N Supports detox pathways* nutritional support to counterbalance the healthy glutathione level* occasional gastrointestinal effects that can N Promotes healthy mitochondrial accompany metformin. function & NK cell function* Joseph Burrascano Jr., MD This placebo-controlled, double-blind, randomized, crossover study assessed type “Due to the research basis of these formulations, I think these products would be an important part of a practitioner’s arsenal.” 2 diabetics with documented metformin intolerance.23 Each of the 2 treatment periods lasted 2 weeks, with a 2-week *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. washout period between them. All subjects continued to take daily metformin. 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Figure 1. Production of SCFAs from Prebiotics addition, subjects ingested either placebo (cellulose) or the GIMM. No changes were made to their daily meal routines. Frequency and consistency of bowel movements and metformin tolerability Volume 15 Issue 1 | January 2019 were assessed via questionnaires, and fasting blood glucose was monitored via Publisher Razi Ann Berry morning finger-stick tests. [email protected] Results showed improved tolerance Founders of metformin (Figure 6) in the prebiotic Razi Ann Berry group, as compared to the placebo group, David A. Tallman, DC, ND [email protected] as well as improved bowel movement regularity and consistency (loose-to- Medical Editor Mary James, ND firm stools), all without compromising Cross-feeding of microbiota: Use of hydrogen from an initial fermentation produces undesirable the drug’s usual therapeutic effect on Associate Medical Editor gases and more SCFAs through a competitive process David A. Tallman, DC, ND regulating glucose levels. In summary, the 2 clinical studies Associate Editor & Director of CE Node Smith, ND Figure 2. Polyphenols Shift the Competitive Balance of H2 Utilization discussed here demonstrate that this prebiotic blend was effective at reducing the Contributing Editor, Education David Schleich, PhD desire to eat and in reducing the amount of food anticipated or considered sufficient Contributing Editors, Botanical Medicine Jillian Stansbury, ND at the next meal, improving regularity Robin DiPasquale, ND, RH (AHG) from occasional GI disturbances, lowering Contributing Editor, Homeopathy mealtime blood sugar levels, protecting Joseph Kellerstein, DC, ND and preparing the GI immune system, and Contributing Editor, Oncology improving metformin tolerability. Jacob Schor, ND, FABNO Contributing Editor, Nature Cure Relevance of Prebiotics to Sussanna Czeranko, ND SCFA Production Contributing Editor, Functional Medicine Dietary choices determine substrates Mark Swanson, ND for gut bacterial species, providing a Editorial Coordinator competitive advantage to some microbes Vanessa Wiley [email protected] over others. As explained, dietary prebiotics (fiber and polyphenols) have Director of Sales and Marketing Matthew Knapp a major role in the diversification of [email protected] microbiota and those microbes’ subsequent Polyphenols serve as a key substrate for acetogens to produce acetate (thus reducing biosynthesis of Circulation Manager undesirable gases) role in host metabolism and overall health. Tara Hall The more diverse the diet, the more diverse [email protected] the microbiota, and the more adaptable it Creative Direction can be to disruptions. Jaclyn Threadgill [email protected] During the past 30 years, the prevalence www.jthreadgill.com of metabolic disorders has sharply 24-26 Foreign Correspondent increased while gut microbiome diversity S.A. Decker Weiss, NMD, FASA Dietary prebiotics (fiber and polyphenols) has decreased.27,28 Additions or losses of species with similar roles tend to only have a major role in the diversification of have small effects on overall microbiome ND News & Review function. However, domination by a few PO BOX 2968 Scottsdale, AZ 85252-2968 microbiota and those microbes’ subsequent species or a reduction in species diversity 888.627.8677 | 480.275.7712 www.ndnr.com can significantly impact physiological ISSN 2169-1614 role in host metabolism and overall health. functions, specifically those related to host Our printer utilizes wind-power metabolism and host defenses (ie, gut The more diverse the diet, the more diverse barrier function and immunity). Naturopathic Doctor News & Review As evidenced by both human and Copyright © 2018 Naturopathic Doctor News & Review. All animal studies, diet can cause a shift in rights reserved. No portion of this publication may be copied, the microbiota, and the more adaptable it reproduced, or redistributed without express written permis- microbial populations in as little as 3 sion from the publisher. Reprint information is available by contacting [email protected]. Naturopathic Doctor News 29,30 days. Although temporary dietary & Review reserves the right to edit or reject any submitted can be to disruptions. editorial or advertising. Opinions expressed by contributors and changes will only briefly reduce diversity, advertisers are not necessarily the opinions of Naturopathic some losses of microbiota may not be Doctor News & Review or its principals. reversible after a prolonged absence Naturopathic Doctor News & Review is published and circu- lated as a complementary annual subscription (12 issues) of nutrients. This was suggested in a to licensed naturopathic doctors (NDs) and students and graduates of CNME recognized naturopathic colleges in North study in which mice inoculated with America, and certain suppliers to the profession. human microbiota and fed a low-fiber Annual subscriptions (12 issues) are available to other health- diet experienced an irreversible loss care providers and NDs outside of North America: US $99; Canada & Mexico $129USD; Europe and Overseas $179USD. of microbial diversity over several generations despite a reintroduction of dietary fiber.31 In addition, human use of Article Submissions antibiotics, the use of antibiotics in meat Articles should be original, previously unpublished, and should cover a specific topic, protocol, modality, diagnostic, philosophy, production, and the use of pesticides in commentary, or case study pertaining to naturopathic medicine crop agricultural practices can narrow the rather than a general overview. Illustrations, photographs, charts and protocols are encouraged. Naturopathic Doctor News & microbiome.32-34 Pesticides can also subdue Review does not reprint articles from other publications except under unusual circumstances. Typical word requirements are the plant’s own defense system, as the 700 to 2000 words per article. Topics of interest include: • Clinical pearls plant has no need to produce phytoalexins • Case management/case studies (a plant polyphenol with antimicrobial • Naturopathic philosophy • Practice building and business management actions); the end result may be that key • Current trends and issues that affect naturopathic physicians in your area micronutrients that normally nourish the • News, announcements, and event notices gut microbiome are no longer available • Development of new techniques or protocols • Abstracts and reviews when these plants are consumed.35 • Discussions pertaining to diagnostics • Public/media relations and networking Such factors can jeopardize the • Using technology to make practices more efficient and profitable • Educational and grassroots programs that further the natu- microbial production of the SCFAs and ropathic cause thus affect host health. As the body of • Any other trend, event, or development you believe is pertinent to the profession evidence grows supporting the role For more information regarding article submission, or to receive a copy of submission guidelines, please contact [email protected]. of SCFAs as key mediators of host Opinions expressed in NDNR do not necessarily reflect those of metabolism, it becomes increasingly clear this publication and its publishers. NATUROPATHIC DOCTOR NEWS & REVIEW JANUARY 2019 5 ad form Must be coMpleted in full
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that SCFAs represent a key molecular link is implied or made reference to in this Figure 3. Serum Glucose After 4 Weeks of Prebiotics paper and all study materials or related between diet, microbiota, and health. supplements are not intended to diagnose, Studies designed to improve treat, cure, or prevent any disease. microbial diversity using prebiotics have Financial Disclosures: Dale Pfost demonstrated some success, suggesting is the founding CEO of MicroBiome that high levels of non-digestible Therapeutics, the company that carbohydrates may be needed in Western provided the prebiotic blend used in the 2 studies discussed in this article. diets to produce relevant changes in Dr Erick Cervantes is an ambassador SCFA production, along with nutritional for MicroBiome Therapeutics, and counseling and behavior modification recommends a proprietary version of the surrounding dietary choices. GIMM to appropriate patients. Fortunately, the increase in prevalence Acknowledgments: The authors wish to of type 2 diabetes, obesity, inactivity, and the acknowledge the primary contribution ubiquitous SAD diet has led to an increasing to the research and development of the GIMM described here by Mark focus on disease prevention. Prebiotics Heiman, PhD, who is the CSO emeritus have been proven in numerous studies to Note: Blood glucose excursion was significantly improved after 4 weeks. There was a significant of MicroBiome Therapeutics. Dr Heiman postprandial effect and greater effect in diabetic subjects (those with A1c >6.5%). Fasting blood alter the gut microbiome in favorable ways, and Dr Frank Greenway are both scientific glucose normalized to 0. and continuing research is now illustrating advisors to MicroBiome Therapeutics. (GIMM = Gastrointestinal Microbiome Modulator) the power of prebiotics to impact health beyond the gut as well, especially metabolic Erick R. Cervantes, MPH, ND, is a Figure 4. Increased Satiety After 4 Weeks of Prebiotics disorders. SCFAs’ ability to affect appetite 2011 graduate of NCNM in Portland, OR. Dr Cervantes is currently Program and glucose regulation suggests that they Chair and Assistant Professor of the may play an important role in protecting Complementary and Alternative Health undergraduate program at Ashford the body against the deteriorating metabolic University in San Diego, CA. He has control and inflammation associated with taught within and led the program and has been practicing naturopathic medicine since 2011. Western lifestyles. Dr Cervantes joined the integrative health center, Body Craft, in October 2017. He uses an array of successful Nourishing the gut microbiota treatment interventions that include: Western herbs, through diet and simple and cost-effective homeopathy, massage, behavioral modification, nutri- tion, German bio-therapeutic drainage therapies, home- interventions such as prebiotics, including opathy, tissue cell salts, herbal stem-cell therapies, and dietary fiber and polyphenols, offers micro-current therapy. significant promise in the prevention of Dale Pfost, PhD, has 25 years of metabolic syndrome and in slowing the experience as a serial entrepreneur progression of prediabetes to diabetes. As we and executive in life sciences. He has A Validated Visual Analog Scale (VAS) was used to measure appetite. Data shown are from the final been the founding CEO of 5 biotech- visit (Week 4). all know, far more important than treating nology companies – achieving 3 IPOs, 3 trade-sales and 3 companies with (GIMM = Gastrointestinal Microbiome Modulator) the symptom is to treat the cause.* market capitalizations of over $2 billion. These include: Oxford GlycoSciences (IPO 1988); Orchid Biosciences (IPO 2000); Acuity References available online at ndnr.com Pharmaceuticals (now OPKO Health, 2007); and NuMe Figure 5. SIgA After 4 Weeks of Prebiotics Health (founded 2010, now MicroBiome Therapeutics). Dale is also the US-based General Partner of the * The statements in this paper have not London venture capital firm, Advent Life Sciences. Dale been evaluated by the FDA. No product holds a BS degree from the University of CA and a PhD in physics from Brown University.
The intestinal antibody sIgA normally defends against food allergens and pathogens. Study showed significantly increased sIgA at the final visit (Week 4). (GIMM = Gastrointestinal Microbiome Modulator)
The Wise Choice Figure 6. Metformin Tolerability After 4 Weeks of Prebiotics For digestive health • Supports normal digestion, motility and the healthy absorption of nutrients* • Promotes healthy production of stomach acid and enzymes* wisewomanherbals.com (800) 532-5219
Tolerability Score is a symptom composite of bloating, urgency to evacuate, stool consistency, and flatulence. *This statement has not been evaluated by the Food & Drug (GIMM = Gastrointestinal Microbiome Modulator) Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Continued from bottom of page 1 depression.4,5 Possibly in response to this, precursor, tryptophan, compared to control there has been increasing research into mice.8 This could be due to the elimination the composition of the gut microbiome in of pathogenic or inflammation-inducing individuals with mood disorders. Many bacterial and/or fungal species in the gut. people with psychiatric illnesses have been When in excess, some of these pathogenic found to have an altered gut microbiome enteric microbes can trigger inflammatory Many people with psychiatric illnesses have composition and compromised integrity processes in the CNS. Acutely depressed of the gut lining, and these patterns are patients have been shown to have higher been found to have an altered gut microbiome theorized to affect the functioning of the gut levels of Bacteroidetes, Actinobacteria, nervous system.6 and Proteobacteria, as well as lower levels composition and compromised integrity of the Ever since the 1950s, the only therapy of Firmicutes, compared to patients with widely used to treat mood disorders are milder depression.7 Children with autism gut lining, and these patterns are theorized to pharmaceutical agents that target the spectrum disorder (ASD) have been shown monoamine neurotransmitters in the to have less gut microbial diversity and central nervous system (CNS) – serotonin, lower levels of Prevotella, Coprococcus, and affect the functioning of the nervous system. norepinephrine, and dopamine.7 Recent Veillonellaceae compared to controls.9 research has established a strong Spore-forming anaerobic bacteria and connection between physiological microaerophilic bacteria have also been health and mental health, including found in gastric and duodenal samples from the extensive therapeutic potential of children with ASD, whereas control children cytokines by acting on monocytes, the epithelial lining of the small intestine manipulating the gut microbiome in showed no presence of these microbes.9 macrophages, epithelial cells, peripheral that allow for translocation of partially individuals with mood disorders. blood mononuclear cells, and dendritic digested food products and bacterial toxins The way that the gut communicates Probiotics & Prebiotics cells.10 The eradication of “bad” species of into the bloodstream, often triggering a with the brain is likely the underlying factor The main immunomodulatory actions gut bacteria and the addition of beneficial low-grade immune response through the in this relationship. Extensive research has of probiotics and prebiotics include probiotic species may provide novel interaction of T-cells and compromised been conducted on mice that has included modulating the immune responses from avenues for treatment of mood disorders. epithelium. It has been shown that manipulating their gut microbiota and the gut mucosa, enhancing the integrity “Live bacteria that have a positive mental intestinal hyperpermeability often coexists observing their consequent behavioral of the epithelial barrier in the gut, and health benefit have been defined as with altered gut microbiome composition changes (eg, increased or decreased priming adaptive responses via antigen- psychobiotics.”7 and activity.1 depression and anxiety).8 Findings from presenting cells.10 Disorders characterized by a deviation Immune system hypersensitivity this research strongly support the theory Immunomodulation is primarily from normal gut bacteria include small should also be explored as a possible that these behavioral/mood changes result carried out through regulation of T-cell intestinal bacterial overgrowth (SIBO), contributing factor in the gut-brain from aberrant neurochemical transmission maturation, which is highly implicated in dysbiosis, IBS, and more. It should connection. While the immune system is from the gut microbiome.8 When mice are inflammation and autoimmune disease.10 come as no surprise that there is a high not usually occupied with reacting to non- treated with oral neomycin (antibiotic), The 2 dominant genera of gut bacteria that prevalence of psychiatric illness among harmful antigens, it can start to overreact bacitracin (antibiotic), and primaricin are considered beneficial probiotics are patients with IBS, including panic disorder, to a normally harmless antigen; this is (antifungal), their anxiety is reduced.9 It Lactobacilli and Bifidobacteria.11 Research generalized anxiety disorder, social referred to as an immune hypersensitivity has also been demonstrated that germ-free has demonstrated that Lactobacillus and phobia, posttraumatic stress disorder, reaction. There are several types of mice (mice devoid of gut microorganisms) Bifidobacterium species modulate the and major depression.12 Probiotics hypersensitivity reactions, and they all have higher concentrations of the serotonin production and secretion of various can competitively inhibit disease- and promote inflammation that may affect inflammation-causing pathogenic mood and behavior. It has been found bacteria by blocking attachment sites on that germ-free mice have an increased epithelial cells. Lactobacillus plantarum and stress response, higher cortisol levels, and Lactobacillus rhamnosus upregulate the lower levels of cortical and hippocampal production of intestinal mucins, which brain-derived neurotropic factor (BDNF) greatly reduces the adherence of Escherichia compared to control mice; furthermore, coli O157:H7 and its damaging effects.13 these effects are no longer present when the It has been demonstrated in humans mice are recolonized with Bifidobacteria Mood Support™ Formula that administering a combination of the species.14 Lactobacillus strains have also probiotics Lactobacillus helveticus and been shown to trigger increased levels Bifidobacterium longumhas an anxiolytic of 2 key anti-inflammatory/suppressive effect and reduces serum cortisol.14 cytokines – transforming growth factor- Lactobacillus reuteri is another highly beta (TGF-ß) and interleukin-10 (IL-10) effective probiotic that modulates immune via interaction with dendritic cells.10 system functioning, reduces stress-induced This produces a tolerogenic state such S u p p l e m e n t F a c t s increases in corticosterone, and reduces that immune cells do not hyper-react to Serving size: 3 capsules Servings per container: 30 anxiety by altering the mRNA expression non-harmful antigens (ie, they tolerate Amount per serving %DV Vitamin B1 (as Thiamine HCl) 75 mg 250% of GABAA and GABAB receptors in the them), thereby keeping inflammation Vitamin B2 (as Riboflavin 5' Phosphate) 30 mg 500% 14 10 Vitamin B3 (as Niacinamide) 45 mg 225% CNS. Bifidobacterium infantis has been low. TGF-ß has major regulatory activity, Vitamin B6 (as Pyridoxine HCl) 75 mg 3400% Vitamin B12 (as Methylcobalamin) 1200 mcg 2000% found to have antidepressant effects, induces peripheral antigenic/immune Folinic Acid (as Calcium Folinate) 2400 mcg 600% St. Johns wort (Hypericum) (aerials) (0.3% hypericin) 900 mg * via suppression of stimulation-induced tolerance, and suppresses cells of the L-Tyrosine 750 mg * 16 Skullcap extract (Scutellaria baicalensis) (root) (4:1) 90 mg * elevations in proinflammatory cytokines as innate immune system. Because of its 5-HTP (5-Hydroxytryptophan) 60 mg * well as increasing tryptophan levels.14 broad anti-inflammatory effects, TGF-ß L-Theanine 60 mg * Rhodiola rosea extract (root) (4% rosavins) 108 mg * has been considered a possible therapeutic Ginkgo biloba extract (leaf) (24% ginkgoheterosides and 6% terpene lactones) 45 mg * The Gut-Brain Connection for inflammatory diseases, autoimmune Percent Daily Values are based on a 2,000 calorie diet. * Daily Value not established. There have been rapidly coalescing disease, cancer, and Alzheimer’s disease; it Other ingredients: vegetarian capsules (cellulose and water) clusters of evidence related to the gut-brain might also be considered in the treatment connection, with special focus on potential of severe mood disorders.16 etiologies of anxiety, depression, behavior, and other mental or emotional disorders. Nutritional Impacts “…[I]llnesses such as major depressive on the Gut disorder are disproportionately prevalent The first time nutrition is thought to in patients with gastrointestinal illnesses impact the gut microbiome is shortly after Mood Support™ formula contains highly effective ingredients such as inflammatory bowel disease, which birth. Early life (the weeks and months that nutritionally alter brain chemistry in order to address the pathologically has been strongly linked to following birth) serves as a critical window physiological causes of depression, promote positive mood microbiome function.”15 of opportunity for the development of the regulation and encourage normal neurological function. Intestinal hyperpermeability is a very core microbiome from diet.10 Human breast important pathophysiologic mechanism milk has profound beneficial effects on Learn more about MPN Condition Specific Formulas® implicated in dysbiosis and mood the gut microbiome and is considered the and view full ingredients lists at www.mpn8.com disorders. The hyperpermeability is optimal source of nutrition for newborns. To order call toll free (877) 686-7325 characterized by weakened tight junctions Breast milk contains several components between the enterocytes of mainly the that are essential for a maturing *These statements have not been evaluated by the Food and Drug Administration. Products are not intended to diagnose, treat, cure or prevent any disease. small intestine. This creates “gaps” in immune system, including colostrum, 8 JANUARY 2019 NATUROPATHIC DOCTOR NEWS & REVIEW AD FORM MUST BE COMPLETED IN FULL
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immunoglobulins, lysozyme, lactoferrin, resabsorption and decrease fecal pH, which psychiatric and developmental disorders is highly recommended for increasing Lactobacillus acidophilus and L gasseri, both beneficially affect bacterial growth that are increasingly affecting young the concentrations of beneficial gut Bifidobacterium bifidium and B breve, and in the colon.9 Levels of SCFAs (butyrate, children are postulated to result from microbes. The current average American human milk oligosaccharides (HMOs).10 acetate, propionate), along with levels of nutrition and diet during infancy and diet is pro-inflammatory by promoting Some of the general dietary changes different phylogenic microbial strains, can be childhood – factors that significantly affect overgrowth of pathogenic microorganisms, that have occurred in the United States measured via a comprehensive stool analysis. the composition of the gut microbiome. both bacterial and fungal. Enhancing over the past 3 decades include higher Strong but complex connections exist patients’ dietary patterns can serve to caloric intake, higher proportion of Conclusions between the gut microbiome, the immune balance their gut microbiome, decrease calories derived from refined grains/ Anxiety disorders, depressive disorders, system, CNS activity, mood, and behavior. inflammation, optimize nutrient absorption carbohydrates, and increased intake of and autism spectrum disorders have been Research is just beginning to reveal how and utilization, and modulate their corn-derived sweeteners (ie, corn syrup).17 rapidly increasing in prevalence over the these systems interact with each other. immune system. All of these effects should These poor dietary patterns are likely past few decades, especially in the United Although clinical applications are not significantly decrease their symptoms a major culprit in the development of States. Causes of this increase are still yet well supported, it is likely that the of anxiety and depression, and help to psychiatric disorders, mood disorders, largely unknown, but etiologic factors are growing interest in the gut microbiome stabilize their mood. and developmental disorders. A significant beginning to be considered at a deeper will propel further investigation into more amount of evidence exists that shows how level. This fact highlights the need for more specific medical treatments that optimize References available online at ndnr.com dietary interventions (especially gluten-free effective intervention strategies, which can the microbiome. Probiotics are already a and casein-free diets) that help optimize be accomplished through research studies useful clinical tool in the treatment of a the gut microbiome and reduce levels of and clinical trials. Most studies of the gut wide variety of health problems, including inflammation also effectively improve microbiome to date have been conducted psychiatric disorders. Diet therapy, behavioral and digestive symptoms in on mice, which only minimally translate to functional foods, nutritional supplements, Alexandra Francis, ND, MS, CNS, autistic children.18 Foods shown to foster human health. antimicrobial agents, and probiotic therapy was a 4th-year naturopathic medical student at the University of Bridgeport gut bacterial imbalances include sugar, Today, there is a clear need for are all avenues of treatment that have been College of Naturopathic Medicine when eggs, soy, gluten, and dairy.19 These foods alternative treatment strategies for several shown to be highly effective in healing the she wrote this article; she graduated in May 2018. She is also pursuing a trigger some of the most common food common psychiatric conditions including gut, including balancing enteric bacteria, master’s degree in Human Nutrition at the University of Bridgeport Nutrition sensitivities in individuals with intestinal anxiety and depressive disorders. improving the integrity of the epithelial Institute. Alexandra has given several lectures on hyperpermeability (“leaky gut”). Food Pharmaceutical therapy has demonstrated lining, and modulating the activity of subjects including naturopathic medicine, nutrition, therapeutic diets, lifestyle, and wellness. Alexandra sensitivities can be the root cause of many limited efficacy in the general population gastrointestinal immunity. We now plans to start consulting on nutrition, diet, and lifestyle, to complement her clients’ medical treatment in Long common inflammatory manifestations, of psychiatric patients. Many patients know that all of these factors are central Island, NY. including mood disorders. with psychiatric illness are prescribed to the functioning of the CNS and the Short-chain fatty acids (SCFAs), such indicated medications and become reliant pathophysiology of psychiatric disorders. Marie Winters, ND, FABNO, received her ND degree from Bastyr University in as butyrate, acetate, and propionate, have on them for a significant portion of their Nutritional therapy is one of the 2006. Dr Winters is the former director of been shown to positively impact the gut lives, despite their often-minimal efficacy most powerful tools for altering the gut the Naturopathic Medicine Department at Cancer Treatment Centers of America microbiota and exert modulatory effects on and the fact that they are often intended microbiome. It has been shown that even in Philadelphia. She is also a Fellow of the immune system.17 Increased fiber intake to be used only for a short period of short-term dietary changes significantly the American Board of Naturopathic Oncology, sits on the Board of Medical can enhance SCFA status, since SCFAs are time. As an alternative to pharmaceutical affect (positively or negatively) the Examiners for the American Board of Naturopathic Oncology, and is currently President of the PA products of anaerobic microbial fermentation therapy, treatment designed to reduce populations of microorganisms in Association of Naturopathic Physicians. She is an of non-digestible macronutrients (mostly CNS inflammation and optimize the gut the GI tract. In general, a high fiber, adjunct professor at Bridgeport University’s College of Naturopathic Medicine and maintains a private practice plant polysaccharides and resistant microbiome may be a novel and highly plant-based diet, in conjunction with in Philadelphia. Dr Winters has spoken at several medi- starches).17 SCFAs promote colonic water effective form of therapy. Many of the fermented foods containing probiotics, cal conferences across the country.
MODULATING THE GI MICROBIOME
GASTROINTESTINAL MICROBIOME MODULATOR - GIMM – NOW BIOMEBLISS