High Dose Patch
Copyright #ERS Journals Ltd 1999 Eur Respir J 1999; 13: 238±246 European Respiratory Journal Printed in UK ± all rights reserved ISSN 0903-1936 Higher dosage nicotine patches increase one-year smoking cessation rates: results from the European CEASE trial P. Tùnnesen*, P. Paoletti**, G. Gustavsson+, M.A. Russell#, R. Saracci1, A. Gulsvik", B. Rijcken{, U. Sawe+ , members of the Steering Committee of CEASE on behalf of the European Respiratory Society Higher dosage nicotine patches increase one-year smoking cessation rates: results from the *Dept of Pulmonary Medicine, Gentofte European CEASE trial. P. Tùnnesen, P. Paoletti, G. Gustavsson, M.A. Russell, R. Saracci, Hospital, Hellerup, Denmark, **Eli Lilly, Indianapolis, Ohio, USA, +Pharmacia & A. Gulsvik, B. Rijcken, U. Sawe members of the Steering Committee of CEASE on behalf of # the European Respiratory Society. #ERS Journals Ltd 1999. Upjohn, Helsingborg, Sweden, Smoking Section, Institute of Psychiatry, University ABSTRACT: The Collaborative European Anti-Smoking Evaluation (CEASE) was a of London, London, UK, 1International European multicentre, randomized, double-blind placebo controlled smoking Agency for Research on Cancer, World cessation study. The objectives were to determine whether higher dosage and longer Health Organization, Lyon, France, "Dept duration of nicotine patch therapy would increase the success rate. of Pulmonary Medicine, Haukeland Hos- Thirty-six chest clinics enrolled a total of 3,575 smokers. Subjects were allocated to pital, Bergen, Norway, {Dept of Epidemio- one of five treatment arms: placebo and either standard or higher dose nicotine logy, University of Groningen, Groningen, patches (15 mg and 25 mg daily) each given for 8 or 22 weeks with adjunctive The Netherlands.
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