DOCSLIB.ORG

INFOLETTER 5 – COVID-19 04 April 2020

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

INFOLETTER 5 – COVID-19 04 April 2020 Content overview Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)……………………………………………………………………………………….............3 EMA advice on the use of NSAIDs for Covid-19 ................................................................................... 9 Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement ................................................................................................................................................ 9 Spinal anaesthesia for patients with coronavirus disease 2019 and possible transmission rates in anaesthetists: retrospective, single-centre, observational cohort study ............................10 Italian Society of Interventional Cardiology (GISE) Position Paper for Cath lab‐specific Preparedness Recommendations for Healthcare providers in case of suspected, probable or confirmed cases of COVID‐19 .............................................................................................................10 ECMO for ARDS due to COVID-19 ........................................................................................................11 The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2........................................................................................12 Performance of VivaDiagTM COVID‐19 IgM/IgG Rapid Test is inadequate for diagnosis of COVID‐19 in acute patients referring to emergency room department ............................................13 Guidance for Cardiac Electrophysiology During the Coronavirus (COVID-19) Pandemic from the Heart Rhythm Society COVID-19 Task Force; Electrophysiology Section of the American College of Cardiology; and the Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, American Heart Association .........................................................................13 Analysis of heart injury laboratory parameters in 273 COVID‐19 patients in one hospital in Wuhan, China ........................................................................................................................................15 Can Bioactive Lipids Inactivate Coronavirus (COVID-19)? ................................................................16 Diagnosis and Management of COVID-19 Disease ............................................................................16 Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know ..........................................................................................................................17 1 A Rush to Judgment? Rapid Reporting and Dissemination of Results and Its Consequences Regarding the Use of Hydroxychloroquine for COVID-19 ..................................................................17 Emerging prophylaxis strategies against COVID-19 ..........................................................................18 Treating COVID-19 with Chloroquine...................................................................................................19 Progress and Prospects on Vaccine Development against SARS-CoV-2.........................................19 Developing Covid-19 Vaccines at Pandemic Speed ..........................................................................20 Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2 ...........................................................................................................................................21 Virological assessment of hospitalized patients with COVID-2019 .................................................22 Clinical and virological data of the first cases of COVID-19 in Europe: a case series .....................22 Understanding COVID-19: what does viral RNA load really mean? ...................................................23 Protected Code Stroke: Hyperacute Stroke Management During the Coronavirus Disease 2019 (COVID-19) Pandemic .................................................................................................................24 The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality ......................................................26 COVID-19 and Diabetes: can DPP4 inhibition play a role? .................................................................26 Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19 ...............................................................................................................................................27 What does androgenetic alopecia have to do with COVID-19 An insight into a potential new therapy ...................................................................................................................................................27 Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion .................................................................................................................................28 Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study .....................................................29 Novel coronavirus treatment with ribavirin: Groundwork for evaluation concerning COVID‐19 .....29 COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? ..................................................................................................30 Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing....30 Proposal for international standardization of the use of lung ultrasound for COVID‐19 patients; a simple, quantitative, reproducible method .......................................................................31 Possibility of transmission through dogs being a contributing factor to the extreme Covid‑19 outbreak in North Italy ..........................................................................................................................32 2 Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) https://link.springer.com/article/10.1007%2Fs00134-020-06022-5 Journal: Intensive Care Medicine Published Online: March 28, 2020 Authors from: Canada, Denmark, USA, Saudi Arabia, The Netherlands, China, Italy, Korea... The authors formed a panel of 36 experts from 12 countries. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. They searched the literature for direct and indirect evidence and identified relevant and recent systematic reviews on most questions related to supportive care. Certainty in the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak or in the form of best practice recommendations. The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The full rationale can be found on the link above. Recommendation summary table is enclosed below: Recommendation Strength INFECTION CONTROL AND TESTING 1 For healthcare workers performing aerosol-generating procedures* on Best practice patients with COVID-19 in the ICU, we recommend using fitted respirator statement masks (N95 respirators, FFP2, or equivalent), as opposed to surgical/medical masks, in addition to other personal protective equipment (i.e. gloves, gown, and eye protection, such as a face shield or safety goggles) 2 We recommend performing aerosol-generating procedures on ICU Best practice patients with COVID-19 in a negative pressure room statement 3 For healthcare workers providing usual care for non-ventilated COVID- Weak 19 patients, we suggest using surgical/medical masks, as opposed to respirator masks, in addition to other personal protective equipment (i.e. gloves, gown, and eye protection, such as a face shield or safety goggles) 3 4 For healthcare workers who are performing non-aerosol-generating Weak procedures on mechanically ventilated (closed circuit) patients with COVID-19, we suggest using surgical/medical masks, as opposed to respirator masks, in addition to other personal protective equipment (i.e. gloves, gown, and eye protection, such as a face shield or safety goggles) 5 For healthcare workers performing endotracheal intubation on patients Weak with COVID-19, we suggest using video-guided laryngoscopy, over direct laryngoscopy, if available 6 For COVID-19 patients requiring endotracheal intubation, we Best practice recommend that endotracheal intubation be performed by the statement healthcare worker who is most experienced with airway management in order to minimize the number of attempts and risk of transmission 7.1 For intubated and mechanically ventilated adults with
Recommended publications
  • Study Protocol: LPCN 1021-18-001

    Study Protocol: LPCN 1021-18-001

    Oral Testosterone Undecanoate Protocol No. LPCN 1021-18-001 Lipocine Inc. TU, LPCN 1021 675 Arapeen Drive, Suite 202 Salt Lake City, UT-84108 1.0 TITLE PAGE Clinical Study Protocol: LPCN 1021-18-001 Ambulatory Blood Pressure Monitoring in Oral Testosterone Undecanoate (TU, LPCN 1021) Treated Hypogonadal Men. Investigational Product : Testosterone Undecanoate (TU, LPCN 1021) Date of Protocol : 19 February 2019 FDA IND No. : 106476 Development Phase : Phase 3 Testosterone replacement therapy in adult, 18 years or older, males for conditions associated with a deficiency or absence of endogenous Indication : testosterone – primary hypogonadism (congenital or acquired) or secondary hypogonadism (congenital or acquired) Investigator : Multi-Center, US Sponsor : Lipocine Inc. 675 Arapeen Drive, Suite 202, Salt Lake City, Utah – 84108 Tel: +1-801-994-7383 Fax: +1-801-994-7388 Sponsor / : Nachiappan Chidambaram Emergency Contact 675 Arapeen Drive, Suite 202, Salt Lake City, Utah – 84108 Tel: +1-801-994-7383, Ext 2188 Fax: +1-801-994-7388 Email: [email protected] Protocol Version : 06 Confidentiality Statement This document is a confidential communication of Lipocine Inc. Acceptance of this document signifies agreement by the recipient that no unpublished information contained within will be published or disclosed to a third party without prior written approval, except that this document may be disclosed to an Institutional Review Board under the same conditions of confidentiality. Date: 19 February 2019 Confidential Page 1 of 50 Oral Testosterone Undecanoate Protocol No. LPCN 1021-18-001 Lipocine Inc. TU, LPCN 1021 675 Arapeen Drive, Suite 202 Salt Lake City, UT-84108 2.0 SUMMARY OF CHANGES TO PROTOCOL VERSION 2 Version 02 of the LPCN 1021-18-001 study protocol was developed to make the following changes to the study: • Added sexual desire and sexual distress questions to pre-treatment and post-treatment phases of the study.
  • Customs Tariff - Schedule

    Customs Tariff - Schedule

    CUSTOMS TARIFF - SCHEDULE 99 - i Chapter 99 SPECIAL CLASSIFICATION PROVISIONS - COMMERCIAL Notes. 1. The provisions of this Chapter are not subject to the rule of specificity in General Interpretative Rule 3 (a). 2. Goods which may be classified under the provisions of Chapter 99, if also eligible for classification under the provisions of Chapter 98, shall be classified in Chapter 98. 3. Goods may be classified under a tariff item in this Chapter and be entitled to the Most-Favoured-Nation Tariff or a preferential tariff rate of customs duty under this Chapter that applies to those goods according to the tariff treatment applicable to their country of origin only after classification under a tariff item in Chapters 1 to 97 has been determined and the conditions of any Chapter 99 provision and any applicable regulations or orders in relation thereto have been met. 4. The words and expressions used in this Chapter have the same meaning as in Chapters 1 to 97. Issued January 1, 2020 99 - 1 CUSTOMS TARIFF - SCHEDULE Tariff Unit of MFN Applicable SS Description of Goods Item Meas. Tariff Preferential Tariffs 9901.00.00 Articles and materials for use in the manufacture or repair of the Free CCCT, LDCT, GPT, UST, following to be employed in commercial fishing or the commercial MT, MUST, CIAT, CT, harvesting of marine plants: CRT, IT, NT, SLT, PT, COLT, JT, PAT, HNT, Artificial bait; KRT, CEUT, UAT, CPTPT: Free Carapace measures; Cordage, fishing lines (including marlines), rope and twine, of a circumference not exceeding 38 mm; Devices for keeping nets open; Fish hooks; Fishing nets and netting; Jiggers; Line floats; Lobster traps; Lures; Marker buoys of any material excluding wood; Net floats; Scallop drag nets; Spat collectors and collector holders; Swivels.
  • WO 2018/111890 Al 21 June 2018 (21.06.2018) W !P O PCT

    WO 2018/111890 Al 21 June 2018 (21.06.2018) W !P O PCT

    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2018/111890 Al 21 June 2018 (21.06.2018) W !P O PCT (51) International Patent Classification: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, C07K 16/28 (2006.01) A61K 31/4166 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 59/595 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/US20 17/065841 Declarations under Rule 4.17: (22) International Filing Date: — as to applicant's entitlement to apply for and be granted a 12 December 2017 (12.12.2017) patent (Rule 4.1 7(H)) — as to the applicant's entitlement to claim the priority of the (25) Filing Language: English earlier application (Rule 4.17(Hi)) (26) Publication Langi English — of inventorship (Rule 4.1 7(iv)) (30) Priority Data: Published: 62/433,158 12 December 2016 (12.12.2016) US — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (71) Applicant (for all designated States except AL, AT, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, P T RO, RS, SE, SI, SK, SM, TR): GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, CA 94080-4990 (US).
  • Part I Biopharmaceuticals

    Part I Biopharmaceuticals

    1 Part I Biopharmaceuticals Translational Medicine: Molecular Pharmacology and Drug Discovery First Edition. Edited by Robert A. Meyers. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2018 by Wiley-VCH Verlag GmbH & Co. KGaA. 3 1 Analogs and Antagonists of Male Sex Hormones Robert W. Brueggemeier The Ohio State University, Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Columbus, Ohio 43210, USA 1Introduction6 2 Historical 6 3 Endogenous Male Sex Hormones 7 3.1 Occurrence and Physiological Roles 7 3.2 Biosynthesis 8 3.3 Absorption and Distribution 12 3.4 Metabolism 13 3.4.1 Reductive Metabolism 14 3.4.2 Oxidative Metabolism 17 3.5 Mechanism of Action 19 4 Synthetic Androgens 24 4.1 Current Drugs on the Market 24 4.2 Therapeutic Uses and Bioassays 25 4.3 Structure–Activity Relationships for Steroidal Androgens 26 4.3.1 Early Modifications 26 4.3.2 Methylated Derivatives 26 4.3.3 Ester Derivatives 27 4.3.4 Halo Derivatives 27 4.3.5 Other Androgen Derivatives 28 4.3.6 Summary of Structure–Activity Relationships of Steroidal Androgens 28 4.4 Nonsteroidal Androgens, Selective Androgen Receptor Modulators (SARMs) 30 4.5 Absorption, Distribution, and Metabolism 31 4.6 Toxicities 32 Translational Medicine: Molecular Pharmacology and Drug Discovery First Edition. Edited by Robert A. Meyers. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2018 by Wiley-VCH Verlag GmbH & Co. KGaA. 4 Analogs and Antagonists of Male Sex Hormones 5 Anabolic Agents 32 5.1 Current Drugs on the Market 32 5.2 Therapeutic Uses and Bioassays
  • Tanibirumab (CUI C3490677) Add to Cart

    Tanibirumab (CUI C3490677) Add to Cart

    5/17/2018 NCI Metathesaurus Contains Exact Match Begins With Name Code Property Relationship Source ALL Advanced Search NCIm Version: 201706 Version 2.8 (using LexEVS 6.5) Home | NCIt Hierarchy | Sources | Help Suggest changes to this concept Tanibirumab (CUI C3490677) Add to Cart Table of Contents Terms & Properties Synonym Details Relationships By Source Terms & Properties Concept Unique Identifier (CUI): C3490677 NCI Thesaurus Code: C102877 (see NCI Thesaurus info) Semantic Type: Immunologic Factor Semantic Type: Amino Acid, Peptide, or Protein Semantic Type: Pharmacologic Substance NCIt Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. PDQ Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor
  • Development of a Human 3D Prostate Microtissue Assay for Anti

    Development of a Human 3D Prostate Microtissue Assay for Anti

    Development of a Human 3D Prostate Microtissue Assay for Anti-androgen Screening Chad Deisenroth1, Joshua Harrill1, Cassandra Brinkman1, Menghang Xia2, Kevin Crofton1, Russell Thomas1 1 National Center for Computational Toxicology, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 2 National Center for Advancing Translational Sciences, National Institute of Health, Rockville, MD 20850 Altered androgen hormone biosynthesis and metabolism can modulate androgen levels, contributing to endocrine disruption that may result in impaired reproductive and sexual development. Steroid 5α-reductase isozymes are expressed in key peripheral tissues and catalyze the conversion of testosterone into the more potent androgen 5α - dihydrotestosterone (DHT). Activation of maximal androgen signaling requires conversion of testosterone to DHT to bind to the androgen receptor (AR) and induce transactivation of downstream gene signaling. The evaluation of chemical-mediated disruption of androgen signaling is typically performed through a combination of in vitro and in vivo tests that interrogate both receptor and non-receptor events including accessory sex organ (ASO) development. Chemical-mediated disruption of ASO development may occur via inhibition of 5α-reductase, or direct disruption of AR signaling. The objective here was to establish a higher- tier human-based, in vitro assay of ASO growth using a multiplexed 3D prostate epithelial cell microtissue model. The androgen-sensitive LNCaP cell line was seeded in a 96-well hanging drop culture model to evaluate microtissue growth over a period of 11 days. Prostate Specific Antigen (PSA) secretion, a biomarker for AR signaling, yielded a wide dynamic range with a Positive/Negative control (P/N) ratio of 3,326 and Z’ of 0.78.
  • WSAVA List of Essential Medicines for Cats and Dogs

    WSAVA List of Essential Medicines for Cats and Dogs

    The World Small Animal Veterinary Association (WSAVA) List of Essential Medicines for Cats and Dogs Version 1; January 20th, 2020 Members of the WSAVA Therapeutic Guidelines Group (TGG) Steagall PV, Pelligand L, Page SW, Bourgeois M, Weese S, Manigot G, Dublin D, Ferreira JP, Guardabassi L © 2020 WSAVA All Rights Reserved Contents Background ................................................................................................................................... 2 Definition ...................................................................................................................................... 2 Using the List of Essential Medicines ............................................................................................ 2 Criteria for selection of essential medicines ................................................................................. 3 Anaesthetic, analgesic, sedative and emergency drugs ............................................................... 4 Antimicrobial drugs ....................................................................................................................... 7 Antibacterial and antiprotozoal drugs ....................................................................................... 7 Systemic administration ........................................................................................................ 7 Topical administration ........................................................................................................... 9 Antifungal drugs .....................................................................................................................
  • The Effects of Osaterone Acetate on Clinical Signs and Prostate Volume in Dogs with Benign Prostatic Hyperplasia

    The Effects of Osaterone Acetate on Clinical Signs and Prostate Volume in Dogs with Benign Prostatic Hyperplasia

    Polish Journal of Veterinary Sciences Vol. 21, No. 4 (2018), 797–802 DOI 10.24425/pjvs.2018.125601 Original article The effects of osaterone acetate on clinical signs and prostate volume in dogs with benign prostatic hyperplasia P. Socha, S. Zduńczyk, D. Tobolski, T. Janowski Department of Animal Reproduction with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719 Olsztyn, Poland Abstract A clinical trial was performed to evaluate the therapeutic efficacy of osaterone acetate (OSA) in the treatment of benign prostatic hyperplasia (BPH) in dogs. Osaterone acetate (Ypozane, Virbac) was administered orally at a dose of 0.25 mg/kg body weight once a day for seven days to 23 dogs with BPH. During the 28-day trial, the dogs were monitored five times for their clinical signs and prostate volume. The OSA treatment promoted rapid reduction of clinical scores to 73.2% on day 7 and to 5.9% on day 28 (p<0.05). Osaterone acetate induced the complete clinical remission in approximately 83.0% of the dogs on day 28. The prostate volume regressed to 64.3% of the pretreatment volume after two weeks of the treatment (p<0.05) and to 54.7% at the end of the trial (p<0.05). In conclusion, OSA quickly reduced clinical signs and volume of the prostate glands in dogs with BPH. Key words: dogs, benign prostatic hyperplasia, osaterone acetate, prostate volume Introduction hyperplasia and subsequently transforms to cystic hyperplasia with the formation of multiple small cysts Benign prostatic hyperplasia (BPH) is the most within the prostatic parenchyma.
  • Wipf Group І University of Pittsburgh

    Wipf Group І University of Pittsburgh

    Wipf Group І University of Pittsburgh Serene Tai Research Topic Seminar 1st April 2017 Serene Tai @ Wipf Group Page 1 of 44 4/15/2017 v Prostate - compound tubuloalveolar exocrine gland of the male reproductive system - about the size of a walnut v Prostate cancer - uncontrolled growth of cells in the prostate gland - prostate adenocarcinoma is the major cancer type - 1 in 7 men will be diagnosed with prostate cancer in their lifetime - average age 66; rare before 40 v Symptoms - no symptoms in the early stage - pain and blood in urination, frequent urination, pain in bones and other areas occur in advanced stages American Cancer Society, Cancer Facts & Figures 2017 2 Serene Tai @ Wipf Group Page 2 of 44 4/15/2017 3 Serene Tai @ Wipf Group Page 3 of 44 4/15/2017 v AR is a ligand-dependent nuclear transcription factor that belongs to the steroid hormone receptor superfamily v AR gene encodes a protein of 919 amino acids (110 kDa) v Consists of 4 major functional domains: - N-terminal domain (NTD) - DNA binding domain (DBD) - Hinge region - Ligand binding domain (LBD) v Structure of full length AR has not been solved Acta Pharmacologica Sinica. 2015, 36, 3-23 J. Carcinog. 2011, 10, 20 ACS Chem. Biol. 2016, 11, 2499−2505 4 Serene Tai @ Wipf Group Page 4 of 44 4/15/2017 v Accounts for more than half the size of AR v Contains transactivation function (AF1) v The polyglutamine (polyQ - CAG) and polyglycine (polyG - GGC) tracts affect AR transactivation activity v A combination of experimental and computational analysis suggest that the NTD exists as partially folded protein intermediate (neither full random coil nor stable globular comformation) v Flexible for binding with multiple structurally diverse protein partners Biochem.
  • ESMO E-Learning Metastatic Castrate-Resistant Prostate Cancer

    ESMO E-Learning Metastatic Castrate-Resistant Prostate Cancer

    METASTATIC CASTRATE- RESISTANT PROSTATE CANCER TREATMENT (MCRPC) Fabricio Racca GU, CNS and Sarcoma Programme, Oncology Department Vall d’Hebron University Hospital, Barcelona, Spain AGENDA First-line treatment in mCRPC patients: Standard of Care Androgen Biosynthesis Inhibitors (ABIs) Second generation antiandrogens Docetaxel Radium 223 Novel hormonal therapies Immunotherapy Targeted therapies Failed trials Conclusions Siegel RL, et al., CA Cancer J Clin 2017;67:7–30. © 2017 American Cancer Society. With permission from John Wiley and Sons. SINCE 2010 A PLETHORA OF NEW TRIALS HAVE SHOWN BENEFIT IN MCRPC Trial / agent approved Disease state Comparator Hazard ratio P value IMPACT Chemo-näive CRPC Placebo 0.77 0.032 (Provenge vaccine) 2010 COU-AA-302 Placebo Chemo-naïve CRPC UK UK (Abiraterone acetate) 2012 Prednisone Pre-docetaxel ALSYPMCA (Radium 223) 2013 BSC 0.74 <0.00046 CRPC PREVAIL (Enzalutamide) 2014 Chemo-naïve CRPC Placebo 0.71 <0.0001 Mitoxantrone TAX327 (Docetaxel) 2004 Chemo-naïve CRPC 0.76 0.009 Prednisone Mitoxantrone TROPIC (Cabazitaxel) 2010 Post-docetaxel CRPC 0.70 <0.0001 Prednisone COU-AA-301 Post-docetaxel Placebo 0.65 <0.0001 (Abiraterone acetate) 2010 CRPC Prednisone Post-docetaxel ALSYPMCA (Radium 223) 2013 BSC 0.71 <0.00046 CRPC Post-docetaxel AFFIRM (Enzalutamide) 2012 BSC 0.63 <0.0001 CRPC ANDROGEN BIOSYNTHESIS INHIBITORS (ABIS) ABIRATERONE ACETATE + PREDNISONE Cholesterol Desmolase Renin Deoxy- Pregnenolone Progesterone Corticosterone Aldosterone corticosterone CYP17 17α-hydroxylaseX 11β-Hydroxylase ACTH 17α-OH- 17α –OH- 11-Deoxy- Cortisol pregnenolone progesterone cortisol CYP17 C17,20X-lyase 5α-reductase DHEA Androstenedione Testosterone DHT CYP19: aromatase Estradiol Adapted from Attard G, et al., J Clin Oncol 26(28), 2008: 4563-71.
  • Androgen Receptor Targeted Agents for Castration Resistant Prostate Cancer: a Review of Clinical Effectiveness and Cost- Effectiveness

    Androgen Receptor Targeted Agents for Castration Resistant Prostate Cancer: a Review of Clinical Effectiveness and Cost- Effectiveness

    CADTH RAPID RESPONSE REPORT: SUMMARY WITH CRITICAL APPRAISAL Androgen Receptor Targeted Agents for Castration Resistant Prostate Cancer: A Review of Clinical Effectiveness and Cost- Effectiveness Service Line: Rapid Response Service Version: 1.0 Publication Date: June 6, 2019 Report Length: 30 Pages Authors: Khai Tran, Suzanne McCormack Cite As: Androgen Receptor Targeted Agents for Castration Resistant Prostate Cancer: A Review of Clinical Effectiveness and Cost-Effectiveness. Ottawa: CADTH; 2019 Jun. (CADTH rapid response report: summary with critical appraisal). ISSN: 1922-8147 (online) Disclaimer: The information in this document is intended to help Canadian health care decision-makers, health care professionals, health systems leaders, and policy-makers make well-informed decisions and thereby improve the quality of health care services. While patients and others may access this document, the document is made available for informational purposes only and no representations or warranties are made with respect to its fitness for any particular purpose. The information in this document should not be used as a substitute for professional medical advice or as a substitute for the application of clinical judgment in respect of the care of a particular patient or other professional judgment in any decision-making process. The Canadian Agency for Drugs and Technologies in Health (CADTH) does not endorse any information, drugs, therapies, treatments, products, processes, or services. While care has been taken to ensure that the information prepared by CADTH in this document is accurate, complete, and up-to-date as at the applicable date the material was first published by CADTH, CADTH does not make any guarantees to that effect.
  • (12) United States Patent (10) Patent No.: US 9,636.405 B2 Tamarkin Et Al

    (12) United States Patent (10) Patent No.: US 9,636.405 B2 Tamarkin Et Al

    USOO9636405B2 (12) United States Patent (10) Patent No.: US 9,636.405 B2 Tamarkin et al. (45) Date of Patent: May 2, 2017 (54) FOAMABLE VEHICLE AND (56) References Cited PHARMACEUTICAL COMPOSITIONS U.S. PATENT DOCUMENTS THEREOF M (71) Applicant: Foamix Pharmaceuticals Ltd., 1,159,250 A 1 1/1915 Moulton Rehovot (IL) 1,666,684 A 4, 1928 Carstens 1924,972 A 8, 1933 Beckert (72) Inventors: Dov Tamarkin, Maccabim (IL); Doron 2,085,733. A T. 1937 Bird Friedman, Karmei Yosef (IL); Meir 33 A 1683 Sk Eini, Ness Ziona (IL); Alex Besonov, 2,586.287- 4 A 2/1952 AppersonO Rehovot (IL) 2,617,754. A 1 1/1952 Neely 2,767,712 A 10, 1956 Waterman (73) Assignee: EMY PHARMACEUTICALs 2.968,628 A 1/1961 Reed ... Rehovot (IL) 3,004,894. A 10/1961 Johnson et al. (*) Notice: Subject to any disclaimer, the term of this 3,062,715. A 1 1/1962 Reese et al. tent is extended or adiusted under 35 3,067,784. A 12/1962 Gorman pa 3,092.255. A 6/1963 Hohman U.S.C. 154(b) by 37 days. 3,092,555 A 6/1963 Horn 3,141,821 A 7, 1964 Compeau (21) Appl. No.: 13/793,893 3,142,420 A 7/1964 Gawthrop (22) Filed: Mar. 11, 2013 3,144,386 A 8/1964 Brightenback O O 3,149,543 A 9/1964 Naab (65) Prior Publication Data 3,154,075 A 10, 1964 Weckesser US 2013/0189193 A1 Jul 25, 2013 3,178,352.