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INFOLETTER 5 – COVID-19 04 April 2020

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INFOLETTER 5 – COVID-19 04 April 2020 INFOLETTER 5 – COVID-19 04 April 2020 Content overview Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)……………………………………………………………………………………….............3 EMA advice on the use of NSAIDs for Covid-19 ................................................................................... 9 Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement ................................................................................................................................................ 9 Spinal anaesthesia for patients with coronavirus disease 2019 and possible transmission rates in anaesthetists: retrospective, single-centre, observational cohort study ............................10 Italian Society of Interventional Cardiology (GISE) Position Paper for Cath lab‐specific Preparedness Recommendations for Healthcare providers in case of suspected, probable or confirmed cases of COVID‐19 .............................................................................................................10 ECMO for ARDS due to COVID-19 ........................................................................................................11 The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2........................................................................................12 Performance of VivaDiagTM COVID‐19 IgM/IgG Rapid Test is inadequate for diagnosis of COVID‐19 in acute patients referring to emergency room department ............................................13 Guidance for Cardiac Electrophysiology During the Coronavirus (COVID-19) Pandemic from the Heart Rhythm Society COVID-19 Task Force; Electrophysiology Section of the American College of Cardiology; and the Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, American Heart Association .........................................................................13 Analysis of heart injury laboratory parameters in 273 COVID‐19 patients in one hospital in Wuhan, China ........................................................................................................................................15 Can Bioactive Lipids Inactivate Coronavirus (COVID-19)? ................................................................16 Diagnosis and Management of COVID-19 Disease ............................................................................16 Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know ..........................................................................................................................17 1 A Rush to Judgment? Rapid Reporting and Dissemination of Results and Its Consequences Regarding the Use of Hydroxychloroquine for COVID-19 ..................................................................17 Emerging prophylaxis strategies against COVID-19 ..........................................................................18 Treating COVID-19 with Chloroquine...................................................................................................19 Progress and Prospects on Vaccine Development against SARS-CoV-2.........................................19 Developing Covid-19 Vaccines at Pandemic Speed ..........................................................................20 Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2 ...........................................................................................................................................21 Virological assessment of hospitalized patients with COVID-2019 .................................................22 Clinical and virological data of the first cases of COVID-19 in Europe: a case series .....................22 Understanding COVID-19: what does viral RNA load really mean? ...................................................23 Protected Code Stroke: Hyperacute Stroke Management During the Coronavirus Disease 2019 (COVID-19) Pandemic .................................................................................................................24 The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality ......................................................26 COVID-19 and Diabetes: can DPP4 inhibition play a role? .................................................................26 Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19 ...............................................................................................................................................27 What does androgenetic alopecia have to do with COVID-19 An insight into a potential new therapy ...................................................................................................................................................27 Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion .................................................................................................................................28 Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study .....................................................29 Novel coronavirus treatment with ribavirin: Groundwork for evaluation concerning COVID‐19 .....29 COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? ..................................................................................................30 Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing....30 Proposal for international standardization of the use of lung ultrasound for COVID‐19 patients; a simple, quantitative, reproducible method .......................................................................31 Possibility of transmission through dogs being a contributing factor to the extreme Covid‑19 outbreak in North Italy ..........................................................................................................................32 2 Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) https://link.springer.com/article/10.1007%2Fs00134-020-06022-5 Journal: Intensive Care Medicine Published Online: March 28, 2020 Authors from: Canada, Denmark, USA, Saudi Arabia, The Netherlands, China, Italy, Korea... The authors formed a panel of 36 experts from 12 countries. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. They searched the literature for direct and indirect evidence and identified relevant and recent systematic reviews on most questions related to supportive care. Certainty in the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak or in the form of best practice recommendations. The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The full rationale can be found on the link above. Recommendation summary table is enclosed below: Recommendation Strength INFECTION CONTROL AND TESTING 1 For healthcare workers performing aerosol-generating procedures* on Best practice patients with COVID-19 in the ICU, we recommend using fitted respirator statement masks (N95 respirators, FFP2, or equivalent), as opposed to surgical/medical masks, in addition to other personal protective equipment (i.e. gloves, gown, and eye protection, such as a face shield or safety goggles) 2 We recommend performing aerosol-generating procedures on ICU Best practice patients with COVID-19 in a negative pressure room statement 3 For healthcare workers providing usual care for non-ventilated COVID- Weak 19 patients, we suggest using surgical/medical masks, as opposed to respirator masks, in addition to other personal protective equipment (i.e. gloves, gown, and eye protection, such as a face shield or safety goggles) 3 4 For healthcare workers who are performing non-aerosol-generating Weak procedures on mechanically ventilated (closed circuit) patients with COVID-19, we suggest using surgical/medical masks, as opposed to respirator masks, in addition to other personal protective equipment (i.e. gloves, gown, and eye protection, such as a face shield or safety goggles) 5 For healthcare workers performing endotracheal intubation on patients Weak with COVID-19, we suggest using video-guided laryngoscopy, over direct laryngoscopy, if available 6 For COVID-19 patients requiring endotracheal intubation, we Best practice recommend that endotracheal intubation be performed by the statement healthcare worker who is most experienced with airway management in order to minimize the number of attempts and risk of transmission 7.1 For intubated and mechanically ventilated adults with
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