DOCSLIB.ORG

Potassium Perchlorate Hazard Summary

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Potassium Perchlorate Hazard Summary Common Name: POTASSIUM PERCHLORATE CAS Number: 7778-74-7 RTK Substance number: 1577 DOT Number: UN 1489 Date: July 1988 Revision: May 2002 ------------------------------------------------------------------------- ------------------------------------------------------------------------- HAZARD SUMMARY WORKPLACE EXPOSURE LIMITS * Potassium Perchlorate can affect you when breathed in. No occupational exposure limits have been established for * Contact can irritate the skin and eyes. Potassium Perchlorate. This does not mean that this * Breathing Potassium Perchlorate can irritate the nose and substance is not harmful. Safe work practices should always throat. be followed. * High and repeated exposure may affect the thyroid, white blood cells and kidneys. WAYS OF REDUCING EXPOSURE * Where possible, enclose operations and use local exhaust IDENTIFICATION ventilation at the site of chemical release. If local exhaust Potassium Perchlorate is a colorless to white crystalline ventilation or enclosure is not used, respirators should be (sand-like) solid. It is used in explosives, flares, rocket worn. propellants, photography, as a medication, and as an agent in * Wear protective work clothing. automobile safety air bags. * Wash thoroughly immediately after exposure to Potassium Perchlorate and at the end of the workshift. REASON FOR CITATION * Post hazard and warning information in the work area. In * Potassium Perchlorate is on the Hazardous Substance addition, as part of an ongoing education and training List because it is cited by DOT. effort, communicate all information on the health and * Definitions are provided on page 5. safety hazards of Potassium Perchlorate to potentially exposed workers. HOW TO DETERMINE IF YOU ARE BEING EXPOSED The New Jersey Right to Know Act requires most employers to label chemicals in the workplace and requires public employers to provide their employees with information and training concerning chemical hazards and controls. The federal OSHA Hazard Communication Standard, 1910.1200, requires private employers to provide similar training and information to their employees. * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.1020. * If you think you are experiencing any work-related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. POTASSIUM PERCHLORATE page 2 of 6 This Fact Sheet is a summary source of information of all WORKPLACE CONTROLS AND PRACTICES potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance Unless a less toxic chemical can be substituted for a hazardous and other factors will affect your susceptibility to any of the substance, ENGINEERING CONTROLS are the most potential effects described below. effective way of reducing exposure. The best protection is to --------------------------------------------------------------------------- enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also HEALTH HAZARD INFORMATION reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is Acute Health Effects sometimes necessary. The following acute (short-term) health effects may occur immediately or shortly after exposure to Potassium In evaluating the controls present in your workplace, consider: Perchlorate: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether * Contact can irritate the skin and eyes. harmful skin or eye contact could occur. Special controls * Breathing Potassium Perchlorate can irritate the nose and should be in place for highly toxic chemicals or when throat. significant skin, eye, or breathing exposures are possible. Chronic Health Effects In addition, the following control is recommended: The following chronic (long-term) health effects can occur at some time after exposure to Potassium Perchlorate and can * Where possible, automatically transfer Potassium last for months or years: Perchlorate from drums or other storage containers to process containers. Cancer Hazard * According to the information presently available to the New Good WORK PRACTICES can help to reduce hazardous Jersey Department of Health and Senior Services, exposures. The following work practices are recommended: Potassium Perchlorate has not been tested for its ability to cause cancer in animals. * Workers whose clothing has been contaminated by Potassium Perchlorate should change into clean clothing Reproductive Hazard promptly. * There is limited evidence that Potassium Perchlorate may * Do not take contaminated work clothes home. Family damage the thyroid gland in the developing fetus. members could be exposed. * Contaminated work clothes should be laundered by Other Long-Term Effects individuals who have been informed of the hazards of exposure to Potassium Perchlorate. * High and repeated exposure may affect the thyroid, white * Eye wash fountains should be provided in the immediate blood cells and kidneys. work area for emergency use. * If there is the possibility of skin exposure, emergency MEDICAL shower facilities should be provided. * On skin contact with Potassium Perchlorate, immediately Medical Testing wash or shower to remove the chemical. At the end of the Before beginning employment and at regular times after that, workshift, wash any areas of the body that may have for those with frequent or potentially high exposures, the contacted Potassium Perchlorate, whether or not known following is recommended: skin contact has occurred. * Do not eat, smoke, or drink where Potassium Perchlorate * Complete blood count. is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating, drinking, If symptoms develop or overexposure is suspected, the applying cosmetics, smoking, or using the toilet. following are recommended: * Use a vacuum or a wet method to reduce dust during clean- up. DO NOT DRY SWEEP. * Kidney function tests. Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure. Request copies of your medical testing. You have a legal right to this information under OSHA 1910.1020. POTASSIUM PERCHLORATE page 3 of 6 PERSONAL PROTECTIVE EQUIPMENT * Be sure to consider all potential exposures in your workplace. You may need a combination of filters, WORKPLACE CONTROLS ARE BETTER THAN prefilters or cartridges to protect against different forms of a PERSONAL PROTECTIVE EQUIPMENT. However, for chemical (such as vapor and mist) or against a mixture of some jobs (such as outside work, confined space entry, jobs chemicals. done only once in a while, or jobs done while workplace * Where the potential for high exposure exists, use a NIOSH controls are being installed), personal protective equipment approved supplied-air respirator with a full facepiece may be appropriate. operated in a pressure-demand or other positive-pressure mode. For increased protection use in combination with an OSHA 1910.132 requires employers to determine the auxiliary self-contained breathing apparatus operated in a appropriate personal protective equipment for each hazard and pressure-demand or other positive-pressure mode. to train employees on how and when to use protective equipment. QUESTIONS AND ANSWERS The following recommendations are only guidelines and may Q: If I have acute health effects, will I later get chronic not apply to every situation. health effects? A: Not always. Most chronic (long-term) effects result from Clothing repeated exposures to a chemical. * Avoid skin contact with Potassium Perchlorate. Wear protective gloves and clothing. Safety equipment Q: Can I get long-term effects without ever having short- suppliers/manufacturers can provide recommendations on term effects? the most protective glove/clothing material for your A: Yes, because long-term effects can occur from repeated operation. exposures to a chemical at levels not high enough to make * All protective clothing (suits, gloves, footwear, headgear) you immediately sick. should be clean, available each day, and put on before work. Q: What are my chances of getting sick when I have been exposed to chemicals? Eye Protection A: The likelihood of becoming sick from chemicals is * Wear impact resistant eye protection with side shields or increased as the amount of exposure increases. This is goggles. determined by the length of time and the amount of * Wear a face shield along with goggles when working with material to which someone is exposed. corrosive, highly irritating or toxic substances. Q: When are higher exposures more likely? Respiratory Protection A: Conditions which increase risk of exposure include dust IMPROPER USE OF RESPIRATORS IS DANGEROUS. releasing operations (grinding, mixing, blasting, dumping, Such equipment should only be used if the employer has a etc.), other physical and mechanical processes (heating, written program that takes into account workplace conditions, pouring, spraying, spills and evaporation from large requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. surface areas such as open containers), and "confined
Load more

Recommended publications
  • Liothyronine Sodium(BANM, Rinnm) Potassium Perchlorate
    2174 Thyroid and Antithyroid Drugs with methodological limitations. However, a controlled trial of In myxoedema coma liothyronine sodium may be liothyronine with paroxetine could not confirm any advantage of given intravenously in a dose of 5 to 20 micrograms by 3 O additive therapy. slow intravenous injection, repeated as necessary, usu- 1. Aronson R, et al. Triiodothyronine augmentation in the treat- HO I ally at intervals of 12 hours; the minimum interval be- ment of refractory depression: a meta-analysis. Arch Gen Psychi- OH atry 1996; 53: 842–8. tween doses is 4 hours. An alternative regimen advo- 2. Altshuler LL, et al. Does thyroid supplementation accelerate tri- NH2 cates an initial dose of 50 micrograms intravenously cyclic antidepressant response? A review and meta-analysis of I O the literature. Am J Psychiatry 2001; 158: 1617–22. followed by further injections of 25 micrograms every 3. Appelhof BC, et al. Triiodothyronine addition to paroxetine in I 8 hours until improvement occurs; the dosage may the treatment of major depressive disorder. J Clin Endocrinol then be reduced to 25 micrograms intravenously twice Metab 2004; 89: 6271–6. (liothyronine) daily. Obesity. Thyroid drugs have been tried in the treatment of obes- Liothyronine has also been given in the diagnosis of ity (p.2149) in euthyroid patients, but they produce only tempo- NOTE. The abbreviation T3 is often used for endogenous tri-io- hyperthyroidism in adults. Failure to suppress the up- rary weight loss, mainly of lean body-mass, and can produce se- dothyronine in medical and biochemical reports. Liotrix is USAN rious adverse effects, especially cardiac complications.1 for a mixture of liothyronine sodium with levothyroxine sodium.
    [Show full text]
  • Package Insert TECHNETIUM Tc99m GENERATOR for the Production of Sodium Pertechnetate Tc99m Injection Diagnostic Radiopharmaceuti
    NDA 17693/S-025 Page 3 Package Insert TECHNETIUM Tc99m GENERATOR For the Production of Sodium Pertechnetate Tc99m Injection Diagnostic Radiopharmaceutical For intravenous use only Rx ONLY DESCRIPTION The technetium Tc99m generator is prepared with fission-produced molybdenum Mo99 adsorbed on alumina in a lead-shielded column and provides a means for obtaining sterile pyrogen-free solutions of sodium pertechnetate Tc99m injection in sodium chloride. The eluate should be crystal clear. With a pH of 4.5-7.5, hydrochloric acid and/or sodium hydroxide may have been used for Mo99 solution pH adjustment. Over the life of the generator, each elution will provide a yield of > 80% of the theoretical amount of technetium Tc99m available from the molybdenum Mo99 on the generator column. Each eluate of the generator should not contain more than 0.0056 MBq (0.15 µCi) of molybdenum Mo99 per 37 MBq, (1 mCi) of technetium Tc99m per administered dose at the time of administration, and not more than 10 µg of aluminum per mL of the generator eluate, both of which must be determined by the user before administration. Since the eluate does not contain an antimicrobial agent, it should not be used after twelve hours from the time of generator elution. PHYSICAL CHARACTERISTICS Technetium Tc99m decays by an isomeric transition with a physical half-life of 6.02 hours. The principal photon that is useful for detection and imaging studies is listed in Table 1. Table 1. Principal Radiation Emission Data1 Radiation Mean %/Disintegration Mean Energy (keV) Gamma-2 89.07 140.5 1Kocher, David C., “Radioactive Decay Data Tables,” DOE/TIC-11026, p.
    [Show full text]
  • Toxicological Profile for Perchlorates
    PERCHLORATES 15 2. RELEVANCE TO PUBLIC HEALTH 2.1 BACKGROUND AND ENVIRONMENTAL EXPOSURES TO PERCHLORATES IN THE UNITED STATES Perchlorates are high melting point inorganic salts that are soluble in water. There are five perchlorate salts that are manufactured in substantial amounts: magnesium, potassium, ammonium, sodium, and lithium perchlorate. Perchlorates are powerful oxidizing agents and at elevated temperatures, they can react explosively. The production volume of ammonium perchlorate far outpaces the other salts and it is used primarily as the oxidant for solid rocket boosters as well as some other industrial applications. The solid propellant on U.S. Space Shuttle booster rockets is approximately 70% ammonium perchlorate. The rockets that use perchlorates in defense and aerospace activities are engineered to utilize all of the perchlorate during a successful launch. Perchlorates are also used extensively in electroplating, fireworks, munitions, and other pyrotechnic devices. Perchlorates are also present in fertilizers that were made with Chilean saltpeter. Perchlorates are released to the environment from a combination of anthropogenic and natural sources. Perchlorate releases from accidents at manufacturing facilities and unsuccessful rocket launches, as well as activities related to the manufacture, disposal, or research of propellants, explosives, or pyrotechnics, are well documented. Perchlorate releases from fireworks, road safety flares, the use of certain fertilizers, and natural sources of perchlorate in the environment have also been documented. Perchlorate may be released to the environment when certain consumer products that contain perchlorate are used or disposed of. These potential releases are discussed in greater detail in Chapter 6. In water, perchlorates will rapidly dissolve and completely dissociate into the perchlorate anion and the corresponding cation.
    [Show full text]
  • NACB LMPG Thyroid Disease
    Volume 13/2002 The National Academy of Clinical Biochemistry Presents LABORATORY MEDICINE PRACTICE GUIDELINES LABORATORY SUPPORT FOR THE DIAGNOSIS OF THYROID DISEASE ARCHIVED NACB: Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease Laurence M. Demers, Ph.D., F.A.C.B.and Carole A. Spencer Ph.D., F.A.C.B. LABORATORY MEDICINE PRACTICE GUIDELINES Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease Table of Contents Section I. Foreword and Introduction Section 2. Pre-analytic factors Section 3. Thyroid Tests for the Laboratorian and Physician A. Total Thyroxine (TT4) and Total Triiodothyronine (TT3) methods B. Free Thyroxine (FT4) and Free Triiodothyronine (FT3) tests C. Thyrotropin/ Thyroid Stimulating Hormone (TSH) measurement D. Thyroid Autoantibodies: • Thyroid Peroxidase Antibodies (TPOAb) • Thyroglobulin Antibodies (TgAb) • Thyrotrophin Receptor Antibodies (TRAb) E. Thyroglobulin (Tg) Measurement F. Calcitonin (CT) and ret Proto-oncogene G. Urinary Iodide Measurement H. Thyroid Fine Needle Aspiration (FNA) and Cytology I. Screening for Congenital Hypothyroidism Section 4. The Importance of the Laboratory - Physician Interface Appendices and Glossary References Editors: Laurence M. Demers, Ph.D., F.A.C.B. Carole A. Spencer Ph.D., F.A.C.B. Guidelines Committee: The preparation of this revised monograph was achieved with the expert input of the editors, members of the guidelines committee, experts who submitted manuscripts for each section and many expert reviewers, who are listed in Appendix A. The material in this monograph represents the opinions of the editors and does not represent the official position of the National Academy of Clinical Biochemistry or any of the co-sponsoring organizations. The National Academy of Clinical Biochemistry is the official academy of the American Association of Clinical Chemistry.
    [Show full text]
  • Long-Term Use of Potassium Perchlorate J
    Postgrad Med J: first published as 10.1136/pgmj.57.670.516 on 1 August 1981. Downloaded from Postgraduate Medical Journal (August 1981) 57, 516-517 Long-term use of potassium perchlorate J. M. C. CONNELL M.B., M R.C.P. Department of Medicine, Western Infirmary, Glasgow Summary intolerance and excessive sweating, and was re- A case of Graves' disease with potassium per- ferred to the Thyroid Clinic. Apart from pernicious chorate for 22 years without ill effect is described. anaemia affecting a maternal aunt, she gave no Thyrotoxicosis recurred 4 weeks after the medication other history of note. was withdrawn, suggesting that euthyroidism had been On examination she was clinically thyrotoxic, maintained by chronic use of the drug. As toxicity of with warm moist palms and hyperkinetic movements. perchlorate is probably dose related, it is suggested She had a tachycardia of 120 beats/min. A small that long-term use of low dose perchlorate may be no diffuse goitre was palpable, with the left lobe being more hazardous than alternative antithyroid therapy. larger than the right; no bruit was audible. There was no ophthalmopathy. Other examination Protected by copyright. was unremarkable. Introduction Initial thyroid function tests confirmed the clinical Potassium perchlorate was extensively used as an impression with a T4 of 245 nmol/l (normal range antithyroid agent in the late 1950s and early 1960s 59-174), T, of 4.2 nmol/l (normal range 1.29-3.3) (Crooks and Wayne, 1960): by competitive inhibi- and a free thyroxine index of 77.4 (normal range tion of the trapping of iodide by the thyroid it was 17.8-46.1) (Amersham radioimmunoassay kit).
    [Show full text]
  • 202158Orig1s000
    &(17(5)25'58*(9$/8$7,21$1' 5(6($5&+ APPLICATION NUMBER: 2ULJV &/,1,&$/3+$50$&2/2*<$1' %,23+$50$&(87,&65(9,(: 6 Clinical Pharmacology Review _ NDA 202-158 Submission Dates January 4, 2013 SDN 1 January 22, 2013 SDN 2 February 15. 2013 SDN 6 June 24, 2013 SDN 12 July 10, 2013 SDN 13 Type/Category Original-1 (Type 5 - New Formulation or New Manufacturer) Brand Name Sodium Pertechnetate Tc99m Injection USP Generic Name Sodium Pertechnetate Tc99m Injection USP Proposed Indication Sodium Pertechnetate Tc99m Injection produced by a TechneGen Generator System is a diagnostic radiopharmaceutical agent intended for use in children and adults for the following indications: Brain Imaging (including cerebral radionuclide angiography) Thyroid Imaging Salivary Gland Imaging Placenta Localization Blood Pool Imaging (including radionuclide angiography) Urinary Bladder Imaging (direct isotopic cystography) for detection of vesico-ureteral reflux. In addition, it is indicated for use in adults for Nasolacrimal Drainage System Imaging (dacryoscintigraphy). Sodium Pertechnetate Tc99m Injection is also used to reconstitute a variety of reagent kits, commonly referred to as Technetium Tc99m Kits, and with each reconstituted kit used for specified diagnostic imaging indications. (b) (4) Dose (depending on indication) Route of Administration Intravenous Injection; oral; instillation in bladder or eyes Applicant Northstar Medical Radioisotopes, LLC 1 Reference ID: 3379891 Reviewing Division Division of Clinical Pharmacology 5 (DCP 5) Medical Division Division of Medical Imaging Products (DMIP) Primary Reviewer Christy S. John, Ph.D. Secondary Reviewer Gene Williams, Ph.D. _ Table of Contents Page Cover Page 1 Table of Contents 2 1.
    [Show full text]
  • Technical Fact Sheet – Perchlorate November 2017
    Technical Fact Sheet – Perchlorate November 2017 TECHNICAL FACT SHEET – PERCHLORATE Introduction At a Glance This fact sheet, developed by the U.S. Environmental Protection Agency (EPA) Federal Facilities Restoration and Reuse Office (FFRRO), Both naturally occurring and man- provides a summary of the contaminant perchlorate, including physical made anion. and chemical properties; environmental and health impacts; existing Contamination has been found at federal and state guidelines; detection and treatment methods; and sites involved in the manufacture, additional sources of information. This fact sheet provides basic maintenance, use and disposal of information on perchlorate to site managers and other field personnel ammunition and rocket fuel. who are addressing perchlorate contamination at cleanup sites or in drinking water supplies. Highly soluble in water; migrates quickly from soil to groundwater. Primary pathways for human What is perchlorate? exposure include ingestion of Perchlorate is a naturally occurring and man-made anion that - contaminated food and drinking consists of one chlorine atom bonded to four oxygen atoms (ClO4 ). water. Manufactured forms of perchlorate include perchloric acid and salts such as ammonium perchlorate, sodium perchlorate and potassium Affects thyroid gland by interfering perchlorate (EPA FFRRO 2005; ITRC 2005). with iodide uptake. Perchlorate is commonly used in solid rocket propellants, munitions, EPA issued Interim Drinking Water fireworks, airbag initiators for vehicles, matches and signal flares Health Advisory. (EPA FFRRO 2005; ITRC 2005). It is also used in some Various states have screening electroplating operations (ATSDR 2008; ITRC 2005). values or cleanup goals for Of the domestically produced perchlorate, 90 percent is perchlorate in drinking water or manufactured for use in the defense and aerospace industries, groundwater.
    [Show full text]
  • Revised References to Heavy Metals <231>
    Revised References to Heavy Metals <231> Targeted Official Date for Omission of References: 01-January-2018 Title File Type <3> Topical And Transdermal Drug Products--Product Quality Tests General Chapter <661> Containers--Plastics General Chapter <1059> Excipient Performance General Chapter <1086> Impurities In Drug Substances And Drug Products General Chapter <1151> Pharmaceutical Dosage Forms USP Acarbose USP Acebutolol Hydrochloride USP Acesulfame Potassium NF Acetaminophen USP Acetazolamide USP Acetic Acid NF Diluted Acetic Acid NF Glacial Acetic Acid USP & NF Acetohexamide USP Acetohydroxamic Acid USP Acetylcysteine USP & NF Acetyltributyl Citrate NF Acetyltriethyl Citrate NF Acetyltyrosine DS Acitretin USP Adapalene USP Adenine USP Adenosine USP S-Adenosyl-L-methionine Disulfate Tosylate DS Adipic Acid NF Agar NF Alanine USP & DS Alclometasone Dipropionate USP Alcohol in Dextrose Injection USP Alendronate Sodium USP Alfadex NF Alginic Acid NF Alprazolam USP Altretamine USP Ammonium Alum USP Potassium Alum USP Alumina and Magnesia Oral Suspension USP Alumina, Magnesia, and Calcium Carbonate Oral Suspension USP Aluminum Acetate Topical Solution USP Aluminum Chloride USP Aluminum Chlorohydrate USP Aluminum Chlorohydrate Solution USP Aluminum Chlorohydrex Polyethylene Glycol USP Aluminum Chlorohydrex Propylene Glycol USP Aluminum Dichlorohydrate USP Aluminum Dichlorohydrate Solution USP Aluminum Dichlorohydrex Polyethylene Glycol USP Aluminum Dichlorohydrex Propylene Glycol USP Aluminum Hydroxide Gel USP Dried Aluminum Hydroxide Gel
    [Show full text]
  • Efficacy of Administering Simultaneous Oral Perchlorate and Intravenous 99 M Tc0 for Brain Scanning
    Efficacy of Administering Simultaneous Oral Perchlorate and 99 Intravenous m Tc04 - for Brain Scanning Mary E. Maxwell and Bonnie J. Baggenstoss St. Paul-Ramsey Hospital and Medical Center, St. Paul, Minnesota Brain scans were performed using the following TABLE 1. Methods of Perchlorate Administration methods: (A) oral administration of perchlorate at least 30 min before i.v. injection of 99mTc-pertechnetate Number of Group Method studies (99mTc04 -) and (B) simultaneous administration of oral 99 perchlorate and i.v. mTc04 -.The scans were retrospec­ Treat with perchlorate at least 30 min 1,558 tively reviewed for choroid plexus uptake of technetium before i.v. injection of 99mTc04 2 Simultaneous administration of oral 1,233 and scan quality. The simultaneous administration of oral perchlorate a·nd i.v. 99mTc04 99 perchlorate and i.v. mTc04 - is an effective method of 3 No perchlorate given ___!Q performing brain scans and should replace outdated pro­ Total 2,938 tocols requiring treatment with perchlorate before i.v. administration of pertechnetate. The syrup was prepared by (A) dissolving the sodium Most nuclear medicine laboratories use a brain scan perchlorate in distilled water, (B) dissolving the para­ protocol that requires the administration of a per­ hens in ethyl alcohol, and (c) adding the alcohol/ chlorate treating agent, either sodium or potassium, paraben solution to the aqueous sodium perchlorate and 99 before the i.v. administration of mTc04 -. The pre­ bringing the combination to the appropriate volume treatment plan requires an expenditure of extra time with cherry syrup. The final solution should be refrig­ and effort for both technologist and patient.
    [Show full text]
  • PERCHLORATE BLOCKING of 99Mtco4~ UPTAKE BY
    PERCHLORATE BLOCKING OF 99mTcO4~ UPTAKE BY SIMULTANEOUS INTRAVENOUS INJECTION IN DOGS Alan G. Harper, Ben I. Friedman, Kenneth E. Avis, and James Wennemark University of Tennessee Medical Units, Memphis, Tennessee It is current practice in many nuclear medicine were evaluated both qualitatively and quantitatively laboratories to administer potassium perchlorate in dogs. To qualitatively evaluate these solutions (KC1O4) orally 2 hr before the intravenous admin three dogs having an average weight of 18.3 kg were istration of 99mTc-pertechnetate ("9mTcO4-) when given an intravenous injection of each of ten solutions performing brain scans. The oral administration of in varying sequence, either 48 or 120 hr apart. The KC1O, is useful in blocking the uptake of !19mTcO4- dogs were first anesthetized with a 7% sodium pen- in the thyroid, salivary glands, and choroid plexus tobarbital solution at a dose of 35 mg/kg. Each of (1-3). In this report, concentrated solutions of the solutions to be evaluated was then injected 99mTcO4~containing perchlorate ions (CIO,-) pres rapidly into the right saphenous vein and photo ent either as perchloric acid (HC1O4) or sodium graphs made at 10, 30, 60, and 120 min postinjec perchlorate (NaClO4) were administered intrave tion with the Anger gamma camera. nously to dogs. The blocking effect produced by the Three groups of three dogs were used in the quan simultaneous intravenous administration of the titative study. A control group with an average 98mTcO,--ClO, solutions was compared both quali weight of 22.6 kg was given 5 mCi of 99mTcO4- in tatively and quantitatively with that produced by the 0.9% NaCl solution intravenously.
    [Show full text]
  • Perchlorate: Sources, Uses, and Occurrences in the Environment
    University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln U.S. Navy Research U.S. Department of Defense Winter 2005 Perchlorate: Sources, Uses, and Occurrences in the Environment Clayton W. Trumpolt Colorado Department of Public Health and Environment Michael Crain Hazardous, Toxic, and Radioactive Waste Center of Expertise Geoffrey D. Cullison Environmental Readiness Division of the Office of Chief of Naval Operations, [email protected] Susan J. P. Flanagan Institute of Makers of Explosives Lenny Siegel Center for Public Environmental Oversight See next page for additional authors Follow this and additional works at: https://digitalcommons.unl.edu/usnavyresearch Part of the Operations Research, Systems Engineering and Industrial Engineering Commons Trumpolt, Clayton W.; Crain, Michael; Cullison, Geoffrey D.; Flanagan, Susan J. P.; Siegel, Lenny; and Lathrop, Stephen, "Perchlorate: Sources, Uses, and Occurrences in the Environment" (2005). U.S. Navy Research. 25. https://digitalcommons.unl.edu/usnavyresearch/25 This Article is brought to you for free and open access by the U.S. Department of Defense at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in U.S. Navy Research by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Authors Clayton W. Trumpolt, Michael Crain, Geoffrey D. Cullison, Susan J. P. Flanagan, Lenny Siegel, and Stephen Lathrop This article is available at DigitalCommons@University of Nebraska - Lincoln: https://digitalcommons.unl.edu/ usnavyresearch/25 REMEDIATION Winter 2005 Perchlorate: Sources, Uses, and Occurrences in the Environment Clayton W. Trumpolt Michael Crain Geoffrey D. Cullison Perchlorate contamination of groundwater and soil continues to be a hot topic in many sectors, including industry, the federal Departments of Defense and Energy, regulators, and the general public.
    [Show full text]
  • Analysis of Pyrotechnic Components
    Analysis of Pyrotechnic Components Results of chemical, thermal and mechanical insult testing of components of four fireworks samples 31 December 2013 Amy J. R. Bauer Table of Contents Table of Figures ............................................................................................................................................. 3 List of Acronyms ............................................................................................................................................ 4 1.0 Executive Summary ................................................................................................................................. 5 2.0 Introduction ............................................................................................................................................ 5 3.0 Approach and Objectives ........................................................................................................................ 7 4.0 Experimental Methods and Procedures ................................................................................................. 9 4.1 Handling Precautions .......................................................................................................................... 9 4.2 Sample Preparation .......................................................................................................................... 10 4.2.1 Sample Preparation for Mechanical Insult Testing .................................................................... 10 4.2.2 Sample Preparation
    [Show full text]