Flow Chart of main support measures

Careful individual consultation suitable to each party’ s stage and support from the coordinator from the support organizations “Kihara Foundation” and “IDEC ” Intellectual property strategy, Business plan development, Matching, Project initiation, Financing, etc

Technology seeds from Companies’ technology and research institutes and research

●Matching event On the Frontlines of Continuous Innovation Business Idea

●Grant (idea verification, data backing, prototype development) ・LIP. Yokohama Trial Grant Target: SMEs, universities, research institutes, hospitals, NPO corporations, etc. in the city ・“LIP.Yokohama Open Innovation Conference Ⅴ“ Matching event between major companies in various fields and small and Limit: 1 Million yen Grant rate: Within 10/10 medium-sized enterprises(Nov.2019)

●Technology/Needs Presentation ・“The 4th LIP. Yokohama Network Seminar” Presentation of R&D projects that have received research grants from the ●Support for creating technical illustrations “LIP. Yokohama Trial” ・Support for enhancing public relations in the health and medical fields, in (Dec.2019) cooperation with the “Communication Design Center (YCU-CDC)” in the Advanced Medical Research Center at Yokohama City . Project Development

●Overseas development ●Promotion of collaboration between medicine ・Conclusion of a memorandum of mutual cooperation with BIOCOM (San Diego, U.S.) and engineering April 2017 (This is the first memorandum of this type concluded by a Japa- Support for addressing the firsthand needs of the medical field and nese municipality.) participating in business meetings, conferences etc. This support is chiefly ・Holding the world's first business provided by the Yokohama Medical Device Business Group (comprised of acceleration program, “The Spring- approx. 60 manufacturing and IT-related companies focusing on medical board™ Program in Yokohama” in device development etc. and related organizations). cooperation with CONNECT (an entrepreneurial support organiza- tion).

●Support for participating in exhibitions ●Financing support (Pitch event) ・Exhibiting in BioJapan 2019, MEDIX, COMPAMED 2019, and CIIE 2019 “The 13th Yokohama Venture Pitch” (Life Science Field) ・First-time for the city to participate in「BIOCOM DEVICEFEST & DIGITAL (Dec.2019) HEALTH Conference」

Commercialization Market Development

●Healthcare Business ・In the Yokohama Wellness Partners, holding general meetings, exchange meetings, matching meetings, etc, conducting a “Survey on issues” at medical and nursing care sites, and soliciting proposals from companies for solutions to their problem ●National Strategic Special Zones and Comprehensive Special Zones for International Competitiveness ・Support for the realization of new business plans by taking advantage of the merits of special zones, such as: exceptional measures on regulations, tax support, financial support, and funding support

https://businessyokohama.com/home/major-industries/life-science/ Business Alliance Promotion Division, Innovation City Promotion Department, LIP. Yokohama is also introduced on this website: Contact Economic Affairs Bureau, City of Yokohama 6-50-10, Hon-cho, Naka-ku, Yokohama 231-0005 JAPAN Tel: +81-(0)45-671-3495 FAX: 045-664-4867Mail: [email protected] Issued in May 2020 History of Life Innovation in Yokohama Yokohama’s Creation of Bio Clusters

The City of Yokohama recognized the growth potential of the life science industry early on. To promote this growth, the City has supported the establishment of The city has a high concentration of universities and research institutes starting with the RIKEN Yokohama Campus as well as a large number of leading-edge R&D infrastructure, such as the development of the Kanazawa Bio Park, inviting RIKEN to set up operations in Yokohama, and the establishment of manufacturing and information communications companies, creating a favorable environment for research and development in the field of incubation facilities. Currently, enterprises, universities, and research institutes located in the city are engaged in a variety of research and development projects. health and medicine. ③Yagami Campus of the Faculty of Science and Technology at 1988 93 ～ ・Creation of the Kanazawa Bio Park ①Suzukakedai Campus of the ●Suehiro area 2000 Gathering of research institutes, universities, Tokyo Institute of Technology ④RIKEN Yokohama Campus ・Opening of RIKEN to set up the companies, and venture enterprises ②Tokyo Institute of Technology’s ・Tsurumi Campus of (former) Yokohama Institute Yokohama Venture Plaza ・Kihara Memorial Yokohama Foundation for the Advancement of Life Sciences 2001 ・Yokohama Joint Research Center ⑤Yokohama National University ・Yokohama Biotechnology Industry Center(YBIC) ・Establishment of the Yokohama Joint Research ・Yokohama Municipal ・Yokohama Leading Venture Plaza Center (incubation facility) ●Kanazawa Bio Park Citizen’s Hospital Creation of the Suehiro Factory Park 2003 ・Maioka Campus of Yokohama City University (Kihara Institute for Biological Research) (industrial complex) ・Opening of Yokohama Leading Venture Plaza 1 (incubation facility)

Establishment of a department dedicated to the promotion of the life sciences industry in ●Fukuura area ⑥Pacific Convention Plaza Yokohama the Economic Affairs Bureau (PACIFICO Yokohama) ⑦Fukuura Campus of Yokohama City University 2005 (University hospital, Advanced Medical Research Center) ・Kanazawa Bio Park ・Yokohama City University Medical Center ・Opening of Yokohama Leading Venture Plaza ２ (incubation facility) ⑧Yokohama Kanazawa High-Tech Center ・Yokohama Brain and Spine Center ・Start of the life sciences industry advancement initiative by the Kihara Techno-Core 2006 Memorial Yokohama Foundation for the Advancement of Life Sciences Yokohama University of Pharmacy ・Japan Agency for Marine-Earth Science ・“BioJapan” held in Yokohama for the first time at PACIFICO Yokohama and Technology(JAMSTEC) ●Yokohama Joint Research Center ・Establishment of Advanced ・Kanazawa Hakkei Campus of Yokohama City University Medical Research Center of Universities and Manufacturing and information Medical Facilities ● universities and research institutes ● ● Yokohama City University 2009 research institutes 26 157 communications companies 8,250 3,104

(Source) Universities:Yokohama Universities and City Partnership Association, participating universities in Yokohama Source: 2016 Economic Census for Business Activity Source: Yokohama Health and Medicine Plan 2018 ・Opening of the Yokohama Biotechnology Industry Center Research Facilities: 2016 Economic Census for Business Activity 2011 (a rental R&D facility for biotech enterprises)

・Designation of Life Innovation in Keihin Coastal Areas Comprehensive Special Zones for International Competitiveness ●Tsurumi Campus of 2012 Yokohama City University (NMR) ・Completion of Advanced Medical Research Center 2014 Research Building of Yokohama City University ①Suzukakedai Campus of the Tokyo Institute ②Tokyo Institute of Technology’s Yokohama Venture Plaza ③Yagami Campus of the Faculty of Science ④RIKEN Yokohama Campus (a facility of the Organization for Small & Medium Enterprises and Regional Innovation, Japan) ・Designation of a National Strategic Special Zone in Yokohama of Technology and Technology at Keio University 2015

・Launch of Yokohama Medical Equipment Study Group 2016

・Launch of Yokohama Wellness Partners Start of “LIP. Yokohama” ・ 2017

・Memorandum signed with BIOCOM (San Diego, USA) ⑤Yokohama National University ⑥“BioJapan” (held at PACIFICO Yokohama): ⑦Advanced Medical Research Center of ⑧Yokohama Kanazawa High-Tech Center One of the largest bio industry exhibitions in Asia Yokohama City University (Fukuura Campus) Techno-Core

【References】 ●Memorandum signed with BIOCOM Distribution of Bio Venture Life sciences industry accumulation in Number of researchers and engineers Enterprise Headquarters Yokohama and (top 10 government ordinance cities) 141,350 2019 As of the end of January 2015, 63 bio venture There are 313 life sciences-related enterprises in Kanagawa Prefecture, enterprises were based in Kanagawa Yokohama of which 155 (49%) are located in Yokohama. 70,340 Prefecture, which is ranked second among all Kawasaki ・Declaration of Innovation City Yokohama prefectures in Japan. A total of 32 enterprises 53,040 had their head offices in Yokohama. % Nagoya ・Establishment of LIP. YOKOHAMA BIBLIO Yokosuka 3 Other 43,480 % 14 % Osaka Number of Enterprises Atsugi 3 1-4 4% 36,110 Saitama 5-9 Yamato 32,320 10-19 8% Yokohama Sapporo Sagamihara 49% 31,920 20-29 Kobe 30- 25,780 Kawasaki Fukuoka 19% In light of Japan’s progression as a super-aging society, it is expected that the market for businesses 24,460 Promotion of Life Innovation Chiba involved in healthcare equipment and the health & medical field in general, especially in the fields of 24,030 Sendai 0 2 4 6 8 10 12 14 extension of life expectancy and preventive medicine, will expand in the future. Against this backdrop, 0,000 0,000 0,000 0,000 0,000 0,000 0,000(persons) Source: Number of bio venture enterprises by prefecture (January Source: Yano Research Institute Ltd. (as of Sept. 2018)Enterprises with their head the City of Yokohama plans to actively support innovative initiatives in the health & medical field. 2015), published by the Japan Bioindustry Association office in Kanagawa Prefecture Source: Population Census (2015), Ministry of Internal Affairs and Communications Note: Branch offices, etc., are excluded.

1 2 Life Innovation Platform YOKOHAMA (LIP. Yokohama) is designed to help the City of Yokohama collaborate with the industry, ●Utilizing Special Zones academic, government, and financial institutions in order to provide continual support for innovation in the health & medical* LIP. Yokohama Support the promotion of R&D for drugs and medical devices through LIP. Yokohama by utilizing fields in Yokohama.Through this platform, a network of enterprises, universities, and research institutes develops innovative National Strategic Special Zones and Comprehensive Special Zones for International projects. At the same time, LIP. Yokohama supports the commercialization of small, medium-sized, and venture enterprises and Competitiveness promotes the development of new technologies and products. 【Merits】 Exceptional measures on regulations, tax/financial/funding support Drug development, medical device development, diagnostic technology development, preventive medicine, regenerative medicine, nursing care & welfare, health services, etc. *

Small, medium-sized, Large enterprises and venture enterprises

Life Sciences & Bio Fields Overall support for SMEs Financial Overseas collaborating institutions (Support organization: Kihara Memorial Yokohama Foundation) organizations

Individual consultation for business creation in the life sciences field, support for financing opportunities, support for business Revitalization of plan development, etc. Yokohama’s Economy

Formation of a network of collaborating organizations / Creation of new projects

Medical Support for commercialization of SMEs' institutions and venture enterprises' products Health-Related Fields Promotion of healthcare businesses Promotion of the development of new technologies and products Promotion of health & productivity management Rela and the creation of health-related services by ted in it Yokohama Wellness Partners, which is a ia t iv network of enterprises and e other organizations s Medical Devices Field Promotion of collaboration between medicine and engineering Promotion of Health & (Support organization: IDEC Yokohama) Universities Productivity Management Research Provides support for manufacturers and IT-related institutes Dissemination and promotion of “Health and enterprises that engage in areas such as medical Productivity Management” in which health device development through R&D promotion promotion, etc., is considered from a managerial and sales channel expansion point of view and strategically implemented. Yokohama City Note: “Health & productivity management” is a registered RIKEN trademark of the Workshop for the Management of Health on University Company and Employee

Yokohama’s Two Platforms Innovation City Yokohama Health & IoT In January 2019, Mayor Hayashi declared Yokohama an Innovation City. Together with local The City of Yokohama aims to achieve synergy between IoT technologies and Medical field Technology companies and universities, the city will work to further business creation and exchange amongst health & medical initiatives by linking its two platforms (LIP. Yokohama and I-TOP professionals throughout the city. Under the slogan “YOXO,” which stands for Yokohama Crossover, Yokohama [IoT Opening Innovation Partners]) . * the City of Yokohama will work toward the creation and development of new businesses in I-TOP Yokohama is an open innovation platform aimed at creating new businesses, solving social collaboration with commercial industry, academic, government, and financial institutions. ・Contributing solutions for social issues problems,* and supporting small and medium-sized enterprises (SMEs) that utilize IoT and take advan- At “YOXO BOX,” an exchange hub for venture companies established in the Kannai area in October tage of the “concentration of manufacturing and IT industry” that is a source of strength for Yokohama’s ・Support for the challenges SMEs face 2019, the city is implementing support programs for venture companies and entrepreneurs and also economy. ・Creation of new business models hosting event to promote exchange amongst innovative professionals.

3 4 Collaborating Organizations ●Two support organizations LIP. Yokohama aims to create new health & medical technologies and products in Yokohama through collaboration between industry, academic, Careful individual consultation suitable to each party’ s stage and support from the coordinator from the support organizations “Kihara government, and financial institutions. Organizations that agree to contribute to LIP. Yokohama related initiatives will participate in the platform Foundation” and “IDEC Yokohama” as “collaborating organizations.”

Networking ●Universities and Research Institutions in Yokohama participated in LIP.Yokohama

As the only comprehensive natural science research institute in Japan, RIKEN, with bases in various Intellectual property strategy The Kihara Memorial Yokohama Foundation for the Advancement of Life locations across the country, promotes research in a wide range of fields. The RIKEN Yokohama Sciences (Kihara Foundation) was established in 1985 to commemorate Dr. Campus is home to four research centers that explore life science and the environment; the Center Hitoshi Kihara. Dr. Kihara achieved world-class results in the fields of genetics for Integrative Medical Sciences, Center for Biosystems Dynamics Research, Center for Sustainable and evolutionary biology, primarily with a focus on wheat research, and he Resource Science and RIKEN SPring-8 Center. Business plan development established the genome concept as a world first. As an affiliate organization of the City of Yokohama, the foundation encourages life sciences research and supports R&D and business development in the field of life sciences. LIP. Yokohama provides support primarily to life sciences and bio-related SMEs Yokohama City University excels in the fields of cancer, regenerative medicine, and infectious Matching in Yokohama. LIP. Yokohama strives to uncover promising ideas, business diseases, with a world-class level of research activity. The Fukuura Campus has become a site for seeds, and technologies held by enterprises and academia in Yokohama, translational research, with the School of Medicine, University Hospital, and Advanced Medical developing them via matching and project development to promote practical Research Center closely located. The Tsurumi Campus has a joint graduate school program with application and social implementation. RIKEN, and provides a world-class research environment. Project initiation

Taking advantage of its location in the simultaneously global and local city of Yokohama, Kanagawa, Yokohama National University is poised for the global 21st century. In order to achieve its goal of Financing global excellence as an international education hub, the university openly collaborates with businesses from around the world in a variety of sectors and prioritizes contribution to society as well as interdisciplinary education and research. Yokohama Industrial Development Corporation is the only SME support center Acquisition of Grants in Yokohama designated by the mayor of the city through the Small and Medium-sized Enterprise Support Act. The corporation’s coordinators support SMEs in the city when they need to collaborate with a large company or utilize Tokyo Institute of Technology is committed to reforming education, research, and governance with the intellectual properties of universities in order to enter a new market or to the aim of becoming one of the top ten research universities in the world. At the Suzukakedai Productization Commercialization develop new technologies. Campus, we set up the “Institute of Innovative Research” consisting of multiple research institutes, LIP. Yokohama promotes collaboration between entities involved in medicine research centers, and research units, and are promoting leading research in a wide range of fields and engineering, primarily to develop medical devices and other technologies. such as the life sciences, materials, and energy. It engages in activities designed to create business opportunities, such as the Market development provision of information on the needs of the clinical field and matching with medical device manufacturers. At the Yagami Campus located in Kohoku Ward, research activities focusing on science and technology are underway, and by using Keio Leading-edge Laboratory of Science and Technology (KLL) as a window for collaborating between industry-academia-government, we promote giving back to society via cutting-edge research results and research collaboration with companies. It is also LIP.YOKOHAMA BIBLIO characterized by strong collaboration within the university, such as medical-engineering Health and medical-related venture support base (Minato Mirai permanent support site) collaboration that makes use of Keio’s strength as a comprehensive university. Key assistance features * Free to use on normal weekdays from 10:00 to 17:00. Note: advance reservations are required.

・Provides support in the form of online tools for searching articles and research and development data.

・Over 100 books/magazines related to health and medical research, market research reports, etc. are available for perusal.

・For research and business topics within the health and medical industry, consultation is provided by coordinators from pharmaceutical companies with in-depth knowledge of the drug development field and the Pharmaceuticals and Medical Devices Act. (Note: advance reservations are required.)

・Consultations on intellectual property rights are provided by patent attorneys from pharmaceutical companies. (Note: advance reservations are required.)

・Seminars, study sessions, exchange events, etc.

5 6 Open Your Doors to in novation in Yokohama

Issued by Business Alliance Promotion Division, Innovation City Promotion Department, Project Examples Economic Affairs Bureau, City of Yokohama

As of May 2020

Development of new anticancer drugs J-Phama Co., Ltd.

We are developing novel anticancer drugs for half of Japanese people who suffer from cancer, in the combination of "the anticancer drug JPH203 targeting only cancer cells" and "diagnosis for the efficacy of that anticancer drug" with Kyorin University, , and . As for the new anticancer drug JPH203, Phase I clinical trial to confirm safety has been completed, while Phase II clinical trial to demonstrate its efficacy is being conducted.

●Utilization of a grant from the City of Yokohama to promote R&D ● Kihara Foundation’s Support ・Business development consulting ・Business Matching ・Grant application support ・Provision of information related to research and development

New anticancer drug JPH203

Catheter with selective infusion function Piolax Medical Devices,Inc.

We succeeded in the commercialization of LOGOSSWITCH®, a proximal, side-hole, and microballoon catheter which has a selective blood vessel injection function activated by temporarily obstructing the blood vessel during endovascular treatment of liver cancer and the like. The tip of the catheter is obstructed simultaneous to the inflation of the microballoon, which makes it possible to effectively inject a drug solution from the side-hole of the catheter into the fine blood vessel leading to the area affected by the cancer.

●Utilization of a grant from the City of Yokohama to promote R&D ●During medical and engineering collaborations, we provide support in the form of Micro-balloon Side-hole individual consultations together with Yokohama Industrial Development Corporation (IDEC Yokohama) via the initiative for collaboration between medicine and engineering.

Schema Balloon lumen Lumen blocking Balloon mechanism Side-hole Outer tube

Main lumen

Radiopaque marker Inner shaft Cancer-affected area

"Archelis" NITTO Co., Ltd.

Archelis is a wearable chair developed due to clinical need for a “chair which can be put on.” NITTO developed a “wearable leg support device,” which reduces the muscle fatigue of doctors and other medical staff and enhances the stability of surgical procedures that require doctors and other medical staff to stay standing for long periods of time.

●Utilization of a grant from the City of Yokohama to promote R&D

●The project was supported through the Yokohama Industrial Development Corporation (IDEC Yokohama) via the initiative for collaboration between medicine and engineering.

●Yokohama City University cooperated in the pro- totype demonstration experiment. Doctors actually used the prototype during medical operations and assessed/verified its usability, etc. Technical Illustrations Pinpoint Photonics, Inc.

LIP. Yokohama and the Advanced Medical Science Research Center of Yokohama City University “Communication Design Center (YCU-CDC)” provided support to create technical illustrations (pictures and charts that visually convey scientific explanations and techniques). An illustration that provides a visual representation of a complicated mechanism, with a simple design that captures the core functions of the technology, can be effective means of demonstrating the selling points of a company’ s technology and products.

When creating a technical illustration, I noticed features that I would not have noticed normally. By showing a good illustration at an exhibition, I didn’t need to explain the introductory appeal of the product, making it easy to proceed smoothly to the technical explanation. Example

Next-generation monitoring systems for nursing care: supporting product development for companies in the city TAOS Institute, Inc.

Using the “Yokohama Wellness Partners” network, we matched the company with nursing homes, and conducted demonstration tests for product improvement. We succeeded in creating a renewed monitoring system called "Aisleep" made for the purpose of securing the safety of elderly patients and reducing the workload for caregivers. It is possible to monitor respiratory rates, detect the state of sleep, and check when the patient gets out of bed with a pneumatic sensor.

By introducing a nursing care facility to act as a demonstration test location, we were able to listen to the opinions of people working in the field to incorporate functions that will be useful on site.

Example AiSleep

Developing a health management promotion program for small and medium-sized companies in the city Yokohama Healthcare Consortium

The Yokohama Healthcare Consortium was formed by Sotetsu Group, NTT Docomo Group, the City of Yokohama, and others to develop a health & productivity management promotion program for employees of the city’s SMEs. Using wearable devices and dedicated apps, the consortium visualized the effects of health & productivity manage- ment, economized on manpower for collecting and managing health data, and provided health advice in line with individual values. This program helped people foster health awareness, and aimed to improve corporate productivity and promotion of the healthcare industry. *Ministry of Economy, Trade and Industry Business Creation Projects and Business Selection Projects for the Industry for Extending Healthy Life Expectancy

【Details of support from Yokohama Wellness Partners】 ●Recruitment of participant companies utilizing corporate networks ●Establishment of open innovation systems for participating companies

Ｄedicated apps Ｗearable devices