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Role of Endolysosomes and Inter-Organellar Signaling in Brain Disease
University of North Dakota UND Scholarly Commons Biomedical Sciences Faculty Publications Department of Biomedical Sciences 2-2020 Role of endolysosomes and inter-organellar signaling in brain disease Zahra Afghah Xuesong Chen University of North Dakota, [email protected] Jonathan David Geiger University of North Dakota, [email protected] Follow this and additional works at: https://commons.und.edu/bms-fac Part of the Medicine and Health Sciences Commons Recommended Citation Afghah, Zahra; Chen, Xuesong; and Geiger, Jonathan David, "Role of endolysosomes and inter-organellar signaling in brain disease" (2020). Biomedical Sciences Faculty Publications. 1. https://commons.und.edu/bms-fac/1 This Article is brought to you for free and open access by the Department of Biomedical Sciences at UND Scholarly Commons. It has been accepted for inclusion in Biomedical Sciences Faculty Publications by an authorized administrator of UND Scholarly Commons. For more information, please contact [email protected]. Neurobiology of Disease 134 (2020) 104670 Contents lists available at ScienceDirect Neurobiology of Disease journal homepage: www.elsevier.com/locate/ynbdi Review Role of endolysosomes and inter-organellar signaling in brain disease T ⁎ Zahra Afghah, Xuesong Chen, Jonathan D. Geiger Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58201, United States of America ARTICLE INFO ABSTRACT Keywords: Endosomes and lysosomes (endolysosomes) are membrane bounded organelles that play a key role in cell sur- Endolysosomes vival and cell death. These acidic intracellular organelles are the principal sites for intracellular hydrolytic Mitochondria activity required for the maintenance of cellular homeostasis. -
Plant Responses to Abiotic Stresses and Rhizobacterial Biostimulants: Metabolomics and Epigenetics Perspectives
H OH metabolites OH Review Plant Responses to Abiotic Stresses and Rhizobacterial Biostimulants: Metabolomics and Epigenetics Perspectives Motseoa M. Lephatsi 1 , Vanessa Meyer 2 , Lizelle A. Piater 1 , Ian A. Dubery 1 and Fidele Tugizimana 1,3,* 1 Department of Biochemistry, University of Johannesburg, Auckland Park, Johannesburg 2006, South Africa; [email protected] (M.M.L.); [email protected] (L.A.P.); [email protected] (I.A.D.) 2 School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, WITS, Johannesburg 2050, South Africa; [email protected] 3 International Research and Development Division, Omnia Group, Ltd., Johannesburg 2021, South Africa * Correspondence: [email protected]; Tel.: +27-011-559-7784 Abstract: In response to abiotic stresses, plants mount comprehensive stress-specific responses which mediate signal transduction cascades, transcription of relevant responsive genes and the accumulation of numerous different stress-specific transcripts and metabolites, as well as coordinated stress-specific biochemical and physiological readjustments. These natural mechanisms employed by plants are however not always sufficient to ensure plant survival under abiotic stress conditions. Biostimulants such as plant growth-promoting rhizobacteria (PGPR) formulation are emerging as novel strategies for improving crop quality, yield and resilience against adverse environmental conditions. However, to successfully formulate these microbial-based biostimulants and design efficient application programs, the understanding of molecular and physiological mechanisms that govern biostimulant-plant interactions is imperatively required. Systems biology approaches, such as Citation: Lephatsi, M.M.; Meyer, V.; metabolomics, can unravel insights on the complex network of plant-PGPR interactions allowing for Piater, L.A.; Dubery, I.A.; Tugizimana, the identification of molecular targets responsible for improved growth and crop quality. -
Stem- Spraak- En Taalpathologie
Stem- Spraak- en Taalpathologie Supplement, September 2014 15th International Science of Aphasia Conference Stem-, Spraak- en Taalpathologie 32.8310/supplement/1914 Vol. 19, 2014, Supplement 1, pp. 1-197 ©University of Groningen Press i PREFACE Dear participants, We are very pleased to welcome you to the 15th Science of Aphasia conference, being held from September 19 till September 24, 2015 in the San Camillo Hospital in Venice, Italy The 2014 program theme is: Aphasiology: past, present and future Invited speakers are: Ria De Bleser, Audrey Bowen, Marco Catani, Chris Code, Olga Dragoy, Hugues Duffau, David Howard, Peter Mariën, Gabriele Miceli, Carlo Miniussi, Lyndsey Nickels, Carlo Semenza, Cynthia K. Thompson, Evy Visch-Brink, Frank Zanow. The SoA conferences are intended to bring together senior and junior scientists working in the multidisciplinary field Neurocognition of language and to deal with normal function as well as disorders. The size of the conference has a maximum of about 150 participants to ensure direct interaction between the participants. The focus of this year’s conference is on the past, present and future of Aphasiology: The San Camillo Hospital in Venice-Lido is a health care facility, mainly devoted to the rehabilitation outcomes of traumatic brain injury and spinal cord, stroke, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, neuropathy and dementia. In 2005 the hospital received recognition from the Ministry of Health of the Institute for Research, Hospitalization and Health Care (IRCCS) specializes in the "discipline of neuro-rehabilitation motor, communication and behavior." The experience in telemedicine, robotics and Brain Computer Interface (BCI) allowed the hospital to develop a communication system based exclusively on the modulation of brain activity recorded with an electroencephalograph, even without moving a muscle. -
BOC-235 12 De Diciembre De 2011.Indd
GOBIERNO de BOLETÍN OFICIAL DE CANTABRIA CANTABRIA LUNES, 12 DE DICIEMBRE DE 2011 - BOC NÚM. 235 AYUNTAMIENTO DE SANTANDER CVE-2011-15994 Citación para notifi cación por comparecencia de providencia de apre- mio 18712/2011 y otros. Con arreglo a lo dispuesto en el artículo 112 de la Ley 58/2003, de 17 de diciembre, General Tributaria, por el presente anuncio se cita a las personas o entes jurídicos que a continuación se relacionan, a quienes no ha sido posible notifi car por causas no imputables a este Servicio (órgano responsable de la tramitación), para que comparezcan en la Recaudación de Tributos Municipales, calle Antonio López, número 6, bajo, en Santander, de 9 a 14 horas, en el plazo de quince días naturales, contados desde el siguiente al de la publicación de este anuncio, para notifi carles por comparecencia actos administrativos que les afectan cuyas referencias constan seguidamente, con la advertencia de que si no atienden este requerimiento la notifi cación se entenderá producida a todos los efectos legales desde el día siguiente al del vencimiento del plazo señalado para comparecer: Procedimiento que motiva las notifi caciones: Apremio administrativo-providencia apremio. CVE-2011-15994 Pág. 36246i boc.cantabria.es 1/10 GOBIERNO de BOLETÍN OFICIAL DE CANTABRIA CANTABRIA LUNES, 12 DE DICIEMBRE DE 2011 - BOC NÚM. 235 APELLIDOS Y NOMBRE O RAZÓN SOCIAL N.I.F. EXPEDIENTE FECHA ENVÍO Nº ENVÍO Abad Villegas Sergio 72078102N 18712/2011 07/11/2011 1536 Abascal Diego Victor Manuel 13721240S 26059/2011 28/10/2011 275 Abascal Diego Victor -
Licensing Department of Land Management
Town of Southampton Licensing Licensing Review Board Phone: (631) 702-1826 Department of Land Management Fax (631) 287-5754 Bulgin & Associates Inc License Number: 000511-0 Licensee - David E Bulgin & Jeffrey Gagliotti Expires: 02/12/2022 Climbers Tree Care Specialist Inc License Number: L002198 Licensee - Alex R Verdugo Expires: 07/10/2021 CW Arborists Ltd License Number: L002378 Licensee - Michael S Gaines Expires: 09/09/2022 Domiano Pools Inc. D/B/A Pool Fection License Number: 002770-0 Licensee - Joseph P Domiano Jr. Expires: 03/11/2022 East End Centro-Vac Inc. P O Box 412 License Number: 000358-0 Licensee - Dennis V. Finnerty Expires: 03/11/2022 Ecoshield Pest Control of NYC License Number: L005737 Licensee - Ermir Hasija Expires: 10/08/2021 EmPower CES, LLC License Number: L002063 Licensee - David G Schieren Expires: 07/08/2022 Field Stone Dirt Works Corp. License Number: L005874 Licensee - Louis Russo Expires: 06/10/2022 Fire Sprinkler Associates Inc License Number: L001682 Licensee - Mark Mausser Expires: 05/13/2022 Four Seasons Solar Products LLC License Number: L000230 Licensee - Joseph Segreti Expires: 07/08/2022 Green Team USA LLC D/B/A Green Team LI License Number: L005839 Licensee - Jay B Best Expires: 03/11/2022 Harald G. Steudte License Number: L990112 Licensee - Expires: 08/14/2021 Heatco, Inc License Number: L001776 Licensee - Dennis Valenti Expires: 08/12/2022 Hopping Tree Care License Number: L004995 Licensee - John N Hopping Expires: 06/12/2021 J Tortorella Heating & Gas Specialists Inc License Number: L002120 Licensee - John Tortorella Expires: 06/10/2022 Joseph W. Labrozzi Sr. LLC License Number: L005636 Licensee - Joseph W. -
Hunterdon Central Regional High School Monthly Board of Education Meeting April 27, 2020 7:00 PM / Virtual Meeting
Hunterdon Central Regional High School Monthly Board Of Education Meeting April 27, 2020 7:00 PM / Virtual Meeting A. Call to Order – Vincent Panico, Board President B. Open Public Meeting Act Statement Welcome to a meeting of the Hunterdon Central Regional High School Board of Education. Please be advised that this and all meetings of the Board are open to the public and media, consistent with the Open Public Meetings Act (N.J.S.A. 10:4-6) and that advance notice required therein has been provided. Meeting notice was also posted in the Board room of the Upper School Campus; sent to the Courier News, and sent to the Clerks of Delaware Township, East Amwell Township, Flemington Borough, Raritan Township and Readington Township. Notice of this virtual meeting was published in the Courier News on April 15, 2020. The public will have an opportunity to be heard as shown on the Agenda. C. Flag Salute D. Roll Call E. MOVE to approve the regular and executive session minutes of the March 9, 2020, meeting. MOVE to approve the regular minutes of the March 16, 2020, meeting. F. Correspondence • Hunterdon Healthcare G. Superintendent’s Report • Grading During Remote Instruction • February Students of the Month Grade 9 - Scott Anderson, Riley Donnelly, Ella Gohil, Rosa Vargas Anaya Grade 10 - Christian Ley, Luke Mansell, Tanner Peake Grade 11 - Jennifer Horner, Gavin Lefebvre, Estefani Portillo, Alexandra Simone Grade 12 - Patrick Fuller, Griffin Gallagher, Nina Manzi, Ana Olvera Hambleton • March Students of the Month Grade 9 – Natalie Bart, Jorwin Cardona Bautista, Emily Ivanauskas, Patrick Kaczmarek, Sonia Klein Grade 10 – Matsvei Liapich, Mykaylah Moran Grade 11 – Rebecca Kornhaber, Alec McLeester, Mckayla Yard Grade 12 – Rachel Dasti, Abby Gwizdz, Geordan Marrero, Jackson Verrelli • HIB / Suspension Report H. -
Approved Alcoholic Brands 2012-2013
Approved Brands for: 2012/2013 Last Updated: 5/13/2013 * List is grouped based on Brand Type then sorted by Brand name in alphabetical order. Type: D = Distilled Spirits, W = Wines Nashville Knoxville Memphis Chattanooga TypeBrand Name Registrant Area Area Area Area D (ri)1 - Whiskey Jim Beam Brands Co. HORIZON-NASH B&T ATHENS-MEMP HORIZON-CHAT D 10 Cane - Rum Moet Hennessy USA, Inc. HORIZON-NASH TRIPLE C WEST TN CROW HORIZON-CHAT D 100 Anos - Tequila Jim Beam Brands Co. HORIZON-NASH TRIPLE C WEST TN CROW HORIZON-CHAT D 100 Pipers - Whiskey Heaven Hill Distilleries, Inc. LIPMAN KNOX BEVERAGE WEST TN CROW ATHENS-CHAT D 12 Ouzo - Cordials & Liqueurs Skyy Spirits, LLC HORIZON-NASH KNOX BEVERAGE WEST TN CROW HORIZON-CHAT D 13th Colony Southern - Gin Thirteenth Colony Distilleries, LLC HORIZON-CHAT D 13th Colony Southern - Neutral Spirits or Al Thirteenth Colony Distilleries, LLC HORIZON-CHAT D 1776 Bourbon - Whiskey Georgetown Trading Company, LLC HORIZON-NASH HORIZON-CHAT D 1776 Rye - Whiskey Georgetown Trading Company, LLC HORIZON-NASH KNOX BEVERAGE HORIZON-CHAT D 1800 - Flavored Distilled Spirits Proximo Spirits LIPMAN BEV CONTROL ROBILIO HORIZON-CHAT D 1800 - Tequila Proximo Spirits LIPMAN BEV CONTROL ROBILIO HORIZON-CHAT D 1800 Coleccion - Tequila Proximo Spirits LIPMAN BEV CONTROL ROBILIO HORIZON-CHAT D 1800 Ultimate Margarita - Flavored Distilled Proximo Spirits LIPMAN BEV CONTROL ROBILIO HORIZON-CHAT D 1816 Cask - Whiskey Chattanooga Whiskey Company, LLC ATHENS-NASH B&T ATHENS-MEMP ATHENS-CHAT D 1816 Reserve - Whiskey Chattanooga Whiskey Company, LLC ATHENS-NASH B&T ATHENS-MEMP ATHENS-CHAT D 1921 - Tequila MHW, Ltd. -
IU No. FAMILY NAME First Names Country Gen Exam 04801 DEDAJ
IU No. FAMILY NAME First Names Country Gen Exam 04801 DEDAJ Andrea Albania M 2004 12801 GJATA Klodian Albania M 2012 96401 HAXHI Artan Albania M 1996 10101 ABILA Redouane Algeria M 2010 96701 AGGUINI Tahar Algeria M 1996 08301 AISSOU Malha Algeria F 2008 10102 ALICHE Rachid Algeria M 2010 94402 AMMAR Tayeb Algeria M 1994 06701 ATBA BENATBA Ahmed Algeria M 2006 94621 AYAD Ramdane Algeria M 1994 10501 BABOU Safia Algeria F 2010 14901 BENASLA Miloud Algeria M 2014 10502 BENBOUABDELLAH Safia Algeria F 2010 10001 BENDJABALLAH Miloud Algeria M 2010 94602 BENFKHADOU Bouzid Algeria M 1994 98702 BERCHI Mourad Algeria 1998 96702 BETTINE Benamar Algeria M 1996 10103 BEZZIR Mourad Algeria M 2010 96618 BOUCHELOUCHE Samir Algeria M 1996 98802 BOUDJEHEM Abdellah Algeria 1998 08801 BOUHADDA Abderrezak Algeria M 2008 08302 CHERBAL Salah Algeria M 2008 06702 DJEBBAR Rachid Mounir Algeria M 2006 94512 DRICHE Hakim Algeria M 1994 14501 DRID Leila Algeria F 2014 10301 FARES Fouad Algeria M 2010 06901 FEHIS Mohamed Algeria M 2006 10701 GHEDOUCHI Naima Algeria F 2010 08201 HAROUN Mourad Algeria M 2008 92601 ILTACHE Abderrahmane Algeria M 1992 98801 KERKAR Omar Algeria 1998 08001 KHALEM Fella Algeria F 2008 94601 KHERCHI Toufik Algeria M 1994 96722 KIOUL Allel Algeria 1996 04701 LANASRI Said Algeria M 2004 10201 MAALEM IDRISS Mostafa Algeria M 2010 06801 NEDIF Samir Algeria M 2006 10901 NIAR Mourad Algeria M 2010 10801 OMARI Hatem Algeria M 2010 10104 OMARI Redouane Algeria M 2010 94401 OUKACHBI Abdelaziz Algeria 1994 96801 SADOUKI Mokhtar Algeria 1996 06802 -
The SH-SY5Y Cell Line in Parkinson's Disease Research
Xicoy et al. Molecular Neurodegeneration (2017) 12:10 DOI 10.1186/s13024-017-0149-0 REVIEW Open Access The SH-SY5Y cell line in Parkinson’s disease research: a systematic review Helena Xicoy1,2, Bé Wieringa1 and Gerard J.M. Martens2* Abstract Parkinson’s disease (PD) is a devastating and highly prevalent neurodegenerative disease for which only symptomatic treatment is available. In order to develop a truly effective disease-modifying therapy, improvement of our current understanding of the molecular and cellular mechanisms underlying PD pathogenesis and progression is crucial. For this purpose, standardization of research protocols and disease models is necessary. As human dopaminergic neurons, the cells mainly affected in PD, are difficult to obtain and maintain as primary cells, current PD research is mostly performed with permanently established neuronal cell models, in particular the neuroblastoma SH-SY5Y lineage. This cell line is frequently chosen because of its human origin, catecholaminergic (though not strictly dopaminergic) neuronal properties, and ease of maintenance. However, there is no consensus on many fundamental aspects that are associated with its use, such as the effects of culture media composition and of variations in differentiation protocols. Here we present the outcome of a systematic review of scientific articles that have used SH-SY5Y cells to explore PD. We describe the cell source, culture conditions, differentiation protocols, methods/approaches used to mimic PD and the preclinical validation of the SH-SY5Y findings by employing alternative cellular and animal models. Thus, this overview may help to standardize the use of the SH-SY5Y cell line in PD research and serve as a future user’sguide. -
Quantum Physics in Space
Quantum Physics in Space Alessio Belenchiaa,b,∗∗, Matteo Carlessob,c,d,∗∗, Omer¨ Bayraktare,f, Daniele Dequalg, Ivan Derkachh, Giulio Gasbarrii,j, Waldemar Herrk,l, Ying Lia Lim, Markus Rademacherm, Jasminder Sidhun, Daniel KL Oin, Stephan T. Seidelo, Rainer Kaltenbaekp,q, Christoph Marquardte,f, Hendrik Ulbrichtj, Vladyslav C. Usenkoh, Lisa W¨ornerr,s, Andr´eXuerebt, Mauro Paternostrob, Angelo Bassic,d,∗ aInstitut f¨urTheoretische Physik, Eberhard-Karls-Universit¨atT¨ubingen, 72076 T¨ubingen,Germany bCentre for Theoretical Atomic,Molecular, and Optical Physics, School of Mathematics and Physics, Queen's University, Belfast BT7 1NN, United Kingdom cDepartment of Physics,University of Trieste, Strada Costiera 11, 34151 Trieste,Italy dIstituto Nazionale di Fisica Nucleare, Trieste Section, Via Valerio 2, 34127 Trieste, Italy eMax Planck Institute for the Science of Light, Staudtstraße 2, 91058 Erlangen, Germany fInstitute of Optics, Information and Photonics, Friedrich-Alexander University Erlangen-N¨urnberg, Staudtstraße 7 B2, 91058 Erlangen, Germany gScientific Research Unit, Agenzia Spaziale Italiana, Matera, Italy hDepartment of Optics, Palacky University, 17. listopadu 50,772 07 Olomouc,Czech Republic iF´ısica Te`orica: Informaci´oi Fen`omensQu`antics,Department de F´ısica, Universitat Aut`onomade Barcelona, 08193 Bellaterra (Barcelona), Spain jDepartment of Physics and Astronomy, University of Southampton, Highfield Campus, SO17 1BJ, United Kingdom kDeutsches Zentrum f¨urLuft- und Raumfahrt e. V. (DLR), Institut f¨urSatellitengeod¨asieund -
Human Genetics and Clinical Aspects of Neurodevelopmental Disorders
bioRxiv preprint doi: https://doi.org/10.1101/000687; this version posted October 6, 2014. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Human genetics and clinical aspects of neurodevelopmental disorders Gholson J. Lyon1,2,3,*, Jason O’Rawe1,3 1Stanley Institute for Cognitive Genomics, One Bungtown Road, Cold Spring Harbor Laboratory, NY, USA, 11724 2Institute for Genomic Medicine, Utah Foundation for Biomedical Research, E 3300 S, Salt Lake City, Salt Lake City, UT, USA, 84106 3Stony Brook University, 100 Nicolls Rd, Stony Brook, NY, USA, 11794 * Corresponding author: Gholson J. Lyon Email: [email protected] Other author emails: Jason O'Rawe: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/000687; this version posted October 6, 2014. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Introduction “our incomplete studies do not permit actual classification; but it is better to leave things by themselves rather than to force them into classes which have their foundation only on paper” – Edouard Seguin (Seguin, 1866) “The fundamental mistake which vitiates all work based upon Mendel’s method is the neglect of ancestry, and the attempt to regard the whole effect upon off- spring, produced by a particular parent, as due to the existence in the parent of particular structural characters; while the contradictory results obtained by those who have observed the offspring of parents apparently identical in cer- tain characters show clearly enough that not only the parents themselves, but their race, that is their ancestry, must be taken into account before the result of pairing them can be predicted” – Walter Frank Raphael Weldon (Weldon, 1902). -
2020 ESC Guidelin Es for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-Segment Elevation
1 2020 ESC Guidelin es for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation The Task Force for the management of acute coronary syndromes in patients presenting without persistent ST-seg- ment elevation of the European Society of Cardiology (ESC) ESC Guidelines ESC Guidelines Authors/Task Force Members: Jean-Philippe Collet* (Chairperson) [AQ7](France), Holger Thiele* (Chairperson) (Germany), Emanuele Barbato (Italy), Olivier Barthélémy (France), Johann Bauersachs (Germany), Deepak L. Bhatt (USA), Paul Dendale (Belgium), Maria Dorobantu (Romania), Thor Edvardsen (Norway), Thierry Folliguet (France), Chris P. Gale (UK), Martine Gilard (France), Alexander Jobs (Germany), Peter Jüni (Canada), Ekaterini Lambrinou (Cyprus), Basil S. Lewis (Israel), Julinda Mehilli (Germany), Emanuele Meliga (Italy), Béla Merkely (Hungary), Christian Mueller (Switzerland), Marco Roffi (Switzerland), Frans H. Rutten (Netherlands), Dirk Sibbing (Germany), George C.M. Siontis (Switzerland) Document Reviewers: Adnan Kastrati (CPG Review Coordinator) (Germany), Mamas A. Mamas (CPG Review Coordinator) (UK), Victor Aboyans (France), Dominick J. Angiolillo (USA), Hector Bueno (Spain), Raffaele Bugiardini (Italy), Robert A. Byrne (Ireland), Silvia Castelletti (Italy), Alaide Chieffo (Italy), Veronique Cornelissen (Belgium), Filippo Crea (Italy), Victoria Delgado (Netherlands), Heinz Drexel (Austria), Marek Gierlotka (Poland), Sigrun Halvorsen (Norway), Kristina Hermann Haugaa (Norway), Ewa A. Jankowska (Poland), Hugo A. Katus (Germany), Tim Kinnaird (UK), Jolanda Kluin (Netherlands), Vijay Kunadian (UK), Ulf Landmesser (Germany), Christophe Leclercq (France), Maddalena Lettino (Italy), Leena Meinila (Finland), Darren My- lotte (Ireland), Gjin Ndrepepa (Germany), Elmir Omerovic (Sweden), Roberto F. E. Pedretti (Ita- ly), Steffen E. Petersen (UK), Anna Sonia Petronio (Italy), Gianluca Pontone (Italy), Bogdan A. Popescu (Romania), Tatjana Potpara (Serbia), Kausik K.