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Drug Metabolism, Pharmacokinetics and Bioanalysis Drug Metabolism, Pharmacokinetics and Bioanalysis Edited by Hye Suk Lee and Kwang-Hyeon Liu Printed Edition of the Special Issue Published in Pharmaceutics www.mdpi.com/journal/pharmaceutics Drug Metabolism, Pharmacokinetics and Bioanalysis Drug Metabolism, Pharmacokinetics and Bioanalysis Special Issue Editors Hye Suk Lee Kwang-Hyeon Liu MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade Special Issue Editors Hye Suk Lee Kwang-Hyeon Liu The Catholic University of Korea Kyungpook National University Korea Korea Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Pharmaceutics (ISSN 1999-4923) in 2018 (available at: https://www.mdpi.com/journal/ pharmaceutics/special issues/dmpk and bioanalysis) For citation purposes, cite each article independently as indicated on the article page online and as indicated below: LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. Journal Name Year, Article Number, Page Range. ISBN 978-3-03897-916-6 (Pbk) ISBN 978-3-03897-917-3 (PDF) c 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND. Contents About the Special Issue Editors ..................................... vii Preface to ”Drug Metabolism, Pharmacokinetics and Bioanalysis” ................. ix Fakhrossadat Emami, Alireza Vatanara, Eun Ji Park and Dong Hee Na Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals Reprinted from: Pharmaceutics 2018, 10, 131, doi:10.3390/pharmaceutics10030131 ......... 1 Hyeon Kim, Min Sun Choi, Young Seok Ji, In Sook Kim, Gi Beom Kim, In Yong Bae, Myung Chan Gye and Hye Hyun Yoo Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient Reprinted from: Pharmaceutics 2018, 10, 177, doi:10.3390/pharmaceutics10040177 ......... 23 Tae Hwan Kim, Subindra Kazi Thapa, Da Young Lee, Seung Eun Chung, Jun Young Lim, Hyeon Myeong Jeong, Chang Ho Song, Youn-Woong Choi, Sang-Min Cho, Kyu-Yeol Nam, Won-Ho Kang, Soyoung Shin and Beom Soo Shin Pharmacokinetics and Anti-Gastric Ulceration Activity of Oral Administration of Aceclofenac and Esomeprazole in Rats Reprinted from: Pharmaceutics 2018, 10, 152, doi:10.3390/pharmaceutics10030152 ......... 33 Won-Gu Choi, Ju-Hyun Kim, Dong Kyun Kim, Yongnam Lee, Ji Seok Yoo, Dae Hee Shin and Hye Suk Lee Simultaneous Determination of Chlorogenic Acid Isomers and Metabolites in Rat Plasma Using LC-MS/MS and Its Application to A Pharmacokinetic Study Following Oral Administration of Stauntonia Hexaphylla Leaf Extract (YRA-1909) to Rats Reprinted from: Pharmaceutics 2018, 10, 143, doi:10.3390/pharmaceutics10030143 ......... 48 Pil Joung Cho, Sanjita Paudel, Doohyun Lee, Yun Ji Jin, GeunHyung Jo, Tae Cheon Jeong, Sangkyu Lee and Taeho Lee Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol Reprinted from: Pharmaceutics 2018, 10, 141, doi:10.3390/pharmaceutics10030141 ......... 62 Mi Hye Kwon, Jin Seok Jeong, Jayoung Ryu, Young Woong Cho and Hee Eun Kang Pharmacokinetics and Brain Distribution of the Active Components of DA-9805, Saikosaponin A, Paeonol and Imperatorin in Rats Reprinted from: Pharmaceutics 2018, 10, 133, doi:10.3390/pharmaceutics10030133 ......... 75 Young A. Choi, Im-Sook Song and Min-Koo Choi Pharmacokinetic Drug-Drug Interaction and Responsible Mechanism between Memantine and Cimetidine Reprinted from: Pharmaceutics 2018, 10, 119, doi:10.3390/pharmaceutics10030119 ......... 92 Riya Shrestha, Pil Joung Cho, Sanjita Paudel, Aarajana Shrestha, Mi Jeong Kang, Tae Cheon Jeong, Eung-Seok Lee and Sangkyu Lee Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation Reprinted from: Pharmaceutics 2018, 10, 112, doi:10.3390/pharmaceutics10030112 .........104 v Hossain Mohammad Arif Ullah, Junhyeong Kim, Naveed Ur Rehman, Hye-Jin Kim, Mi-Jeong Ahn and Hye Jin Chung A Simple and Sensitive Liquid Chromatography with Tandem Mass Spectrometric Method for the Simultaneous Determination of Anthraquinone Glycosides and Their Aglycones in Rat Plasma: Application to a Pharmacokinetic Study of Rumex acetosa Extract Reprinted from: Pharmaceutics 2018, 10, 100, doi:10.3390/pharmaceutics10030100 .........118 Norzahirah Ahmad, Dodheri Syed Samiulla, Bee Ping Teh, Murizal Zainol, Nor Azlina Zolkifli, Amirrudin Muhammad, Emylyn Matom, Azlina Zulkapli, Noor Rain Abdullah, Zakiah Ismail and Ami Fazlin Syed Mohamed Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract Reprinted from: Pharmaceutics 2018, 10, 90, doi:10.3390/pharmaceutics10030090 ..........130 Yeon Gyeong Kim, Jihye Hwang, Hwakyung Choi and Sooyeun Lee Development of a Column-Switching HPLC-MS/MS Method and Clinical Application for Determination of Ethyl Glucuronide in Hair in Conjunction with AUDIT for Detecting High-Risk Alcohol Consumption Reprinted from: Pharmaceutics 2018, 10, 84, doi:10.3390/pharmaceutics10030084 ..........146 So Jeong Nam, You Jin Han, Wonpyo Lee, Bitna Kang, Min-Koo Choi, Yong-Hae Han and Im-Sook Song Effect of Red Ginseng Extract on the Pharmacokinetics and Efficacy of Metformin in Streptozotocin-Induced Diabetic Rats Reprinted from: Pharmaceutics 2018, 10, 80, doi:10.3390/pharmaceutics10030080 ..........157 Jae-Kyung Heo, Hyun-Ji Kim, Ga-Hyun Lee, Boram Ohk, Sangkyu Lee, Kyung-Sik Song, Im Sook Song, Kwang-Hyeon Liu and Young-Ran Yoon Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry Reprinted from: Pharmaceutics 2018, 10, 79, doi:10.3390/pharmaceutics10030079 ..........167 Seok-Ho Shin, Min-Ho Park, Jin-Ju Byeon, Byeong ill Lee, Yuri Park, Ah-ra Ko, Mi-ran Seong, Soyeon Lee, Mi Ra Kim, Jinwook Seo, Myung Eun Jung, Dong-Kyu Jin and Young G. Shin A Liquid Chromatography-Quadrupole-Time- of-Flight Mass Spectrometric Assay for the Quantification of Fabry Disease Biomarker Globotriaosylceramide (GB3) in Fabry Model Mouse Reprinted from: Pharmaceutics 2018, 10, 69, doi:10.3390/pharmaceutics10020069 ..........181 Yuri Park, Nahye Kim, Jangmi Choi, Min-Ho Park, Byeong ill Lee, Seok-Ho Shin, Jin-Ju Byeon and Young G. Shin Qualification and Application of a Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method for the Determination of Adalimumab in Rat Plasma Reprinted from: Pharmaceutics 2018, 10, 61, doi:10.3390/pharmaceutics10020061 ..........196 Anusha Balla, Kwan Hyung Cho, Yu Chul Kim and Han-Joo Maeng Simultaneous Determination of Procainamide and N-acetylprocainamide in Rat Plasma by Ultra-High-Pressure Liquid Chromatography Coupled with a Diode Array Detector and Its Application to a Pharmacokinetic Study in Rats Reprinted from: Pharmaceutics 2018, 10, 41, doi:10.3390/pharmaceutics10020041 ..........208 vi About the Special Issue Editors Hye Suk Lee acquired her B.S., MS, and Ph.D. degrees at the College of Pharmacy, Sungkyunkwan University, Korea. She has worked as a senior researcher in Toxicology Research Center, Korea Research Institute of Chemical Technology. She also served as professor in College of Pharmacy, Wonkwang University, Korea from 1995 to 2010, and she was a dean of College of Pharmacy, Wonkwang University from 2003 to 2005. In 2011, she moved to College of Pharmacy, The Catholic University of Korea and was a dean of College of Pharmacy from 2014 to 2016. She is currently a director of BK21 Plus Team for Creative Leader Program for Pharmacomics-Based Future Pharmacy since 2013. Dr. Lee has published 210 peer-reviewed articles, and her research has focused on pharmacokinetics and metabolism, drug interaction, and forensic analytical toxicology. She serves on the Editorial members of Pharmaceutics (SCIE), Bioanalysis (SCIE), Mass Spectrometry Letters (SCOPUS), and Integrative Medicine Research (SCOPUS). Kwang-Hyeon Liu acquired his B.S. degree in agricultural chemistry in 1990 from Seoul National University in Suwon, Korea and a Ph.D. in agricultural biotechnology in 1999 from the same university. He then joined BK21 Agricultural Biotechnology, Seoul National University where he was a postdoctoral fellow. He joined Inje University College of Medicine in 2003 and served as a member of the faculty in the Department of Pharmacology. After eight years, he moved to Kyungpook National University in 2011, where he currently serves as a Professor in the College of Pharmacy. While at Inje University and Kyungpook National University, much of his research has focused on drug metabolism/bioanalysis, pharmacokinetics, pharmacometabolomics, and lipidomics, and he has published close to 160 peer-reviewed articles. Currently, Dr. Liu’s research is supported by the National Research Foundation of Korea, Korea Healthcare Technology R&D Project, and Kyungpook National University. He is currently a Director of BK21 Plus KNU Multi-Omics based Creative Drug Research Team, having started in this position in 2016, and is the dean of college of pharmacy, KNU. Dr. Liu is a Founding Member
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