DOCSLIB.ORG

Investigations Into the Causes of Amphibian Malformations in the Lake Champlain Basin of New England

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Investigations Into the Causes of Amphibian Malformations in the Lake Champlain Basin of New England Investigations into the Causes of Amphibian Malformations in the Lake Champlain Basin of New England Prepared By: Richard Levey Vermont Department of Environmental Conservation R.A.LaRosa Environmental Laboratory 103 S. Main St. Waterbury, VT 05671 In Collaboration with: Nathaniel Shambaugh – VT Department of Agricultural, Food & Markets Douglas Fort – Fort Environmental Laboratories James Andrews – Middlebury College Final Report May 2003 Investigations into the Causes of Amphibian Malformations in the Lake Champlain Basin of New England Prepared By: Richard Levey Vermont Department of Environmental Conservation R.A.LaRosa Environmental Laboratory 103 S. Main St. Waterbury, VT 05671 In Collaboration with: Nathaniel Shambaugh – VT Department of Agricultural, Food & Markets Douglas Fort – Fort Environmental Laboratories James Andrews – Middlebury College Final Report May 2003 ACKNOWLEDGMENTS This study would not have been possible without the generous assistance of many individuals. For aid with field work, data collection and management we thank Peter Steckler whose enthusiasm and dedication to the study were unrelenting. Special thanks to Dr. Michael J. Lannoo, for providing radiographic images of Vermont specimens, interpretations of digital and radiographic images and for editorial comments. Dr. Carol Meteyer for providing interpretations of digital and radiographic images and editorial comments. Laura Eaton-Poole for assisting with field surveys and sharing survey results. Douglas Burnham VTDEC project manager, for providing technical and management oversight on the project. The Vermont Department of Environmental Conservation’s RA LaRosa Environmental Laboratory provided chemical and analytical services. Peer review comments from Judy Helgen, Carol Meteyer, Martin Ouellet and William Smith were greatly appreciated. We thank Joseph Tietge from EPA’s Mid- Continent Division in Duluth, MN for providing technical and management oversight on the project. Greg Hellyer from EPA-New England’s Regional Lab provided support for the project and peer review. This project was made possible with funding by the US EPA, Regional Applied Research Effort (RARE). A peer review of the project was conducted in accordance with the US EPA peer review policy and procedures. However, it has not been subject to the US EPA’s policy review, and therefore, does not necessarily reflect the views of that Agency, and thus no official endorsement should be inferred. The Vermont Agency of Natural Resources, Department of Environmental Conservation is an equal opportunity agency and offers all persons the benefits of participating in each of their programs and competing in all areas of employment regardless of race, color, religion, sex, national origin, age, disability, sexual orientation, or other non-merit factors. Persons with a TDD may call 1-800-253-0191 (Vermont Relay Information Service) to communicate requests to offices that do not have a TDD. Disclaimer The mention of trade names or commercial products within this document does not constitute endorsement or recommendations by the State of Vermont, Agency of Natural Resources. TABLE OF CONTENTS List of Figures..........................................................................................................................................i List of Tables ...........................................................................................................................................vi Project Description: Background..........................................................................................................1 Objectives .........................................................................................................................3 Methods ....................................................................................................................................................5 Sampling Design Rationale...............................................................................................5 Site Selection ....................................................................................................................5 Site Characterization.........................................................................................................7 Northern Leopard Frog (R. pipiens) Survey .....................................................................7 Tadpole Surveys................................................................................................................8 Drift-Fence Monitoring at Ward Marsh 1998-2001 .........................................................8 Limb Bud Assays..............................................................................................................13 Water Quality Measurements ...........................................................................................14 Water and Sediment Collection for Pesticide Analysis and Limb Bud Assays 14 Pesticide Analysis .............................................................................................................16 Results ......................................................................................................................................................21 Site Characterizations .......................................................................................................21 Northern Leopard Frog (R. pipiens) Metamorph Surveys................................................27 Categories of Metamorph Abnormalities..........................................................................35 Age and Growth – Metamorphs........................................................................................46 Tadpole Surveys – Rana pipiens.......................................................................................52 Growth – Tadpoles............................................................................................................60 Drift-Fence Monitoring at Ward Marsh 1998-2001 .........................................................63 Limb Bud Assays..............................................................................................................95 Water Quality Measurements – Field ...............................................................................120 Water Quality Measurements – Laboratory......................................................................124 Pesticides...........................................................................................................................131 Discussion.................................................................................................................................................136 References................................................................................................................................................146 Appendices: Rana pipiens Metamorph and Tadpole Data .........................................................................Appendix A Photo Atlas: Radiographs of Rana pipiens ............................................................................Appendix B Photo Atlas: Rana pipiens Metamorph..................................................................................Appendix C Photo Atlas: Rana pipiens Larvae..........................................................................................Appendix D Raw Data-Limb Bud Assays –Water Chemistry ...................................................................Appendix E Photo Atlas: Rana pipiens and Xenopus laevis......................................................................Appendix F Definitions..............................................................................................................................Appendix G LIST OF FIGURES Figure 1. Lake Champlain Basin Map ......................................................................................................4 Figure 2. Sampling Sites...........................................................................................................................6 Figure 3. Location of Seven Drift-Fences at Ward Marsh in West Haven, VT .......................................9 Figure 4. Diagram of the Design of the Drift-Fences ...............................................................................10 Figure 5. Drift-fence at Ward Marsh in West Haven, VT ........................................................................11 Figure 6. Otter Creek WMA .....................................................................................................................21 Figure 6a. Otter Creek Wetland................................................................................................................21 Figure 7. Mud Creek WMA......................................................................................................................22 Figure 7a. Mud Creek Marsh....................................................................................................................22 Figure 8. Alburg Dune State Park.............................................................................................................23 Figure 9. Arial Photograph of Alburg.......................................................................................................24 Figure 9a. North Hero Floodplain.............................................................................................................24 Figure 10. North Hero Study Site .............................................................................................................25
Load more

Recommended publications
  • FROGLOG Newsletter of the Declining Amphibian Populations Task Force
    Salamandra salamandra by Franco Andreone ISSN 1026-0269 FROGLOG Newsletter of the Declining Amphibian Populations Task Force August 2004, Number 64. Meteyer et al. (2000) and Ouellet very low number of abnormalities. We (2000). only found one L. kuhlii, which may We examined a total of 4,331 have strayed from a nearby stream. frogs of 23 species and found 20 A third of abnormalities were types of deformities in 9 species of due to trauma; these included digit frogs. We divided deformities into two amputations (16% of all general types: developmental abnormalities), limb amputations (2%), abnormalities and trauma (injuries). fractured limbs (7%) and skin wounds Morphological Abnormalities in We distinguished trauma (4%). The most common Frogs of West Java, Indonesia abnormalities based on the developmental abnormalities were appearance of old scars or, if they digital (43%) and, of these, By Mirza D. Kusrini, Ross A. Alford, involved digits, the occurrence of brachydactyly (16.3%), syndactyly Anisa Fitri, Dede M. Nasir, Sumantri digital re-growth. Developmental (14.6%) and ectrodactyly (11.4%) Rahardyansah abnormalities occurred in limbs were the three most common. In recent decades, amphibian (amelia, micromelia, brachymelia, The oldest specimen of F. deformities have generated public hemimelia, ectromelia, taumelia, cuta- limnocharis stored in the MZB that interest as high incidences have been neous fusions), digits (ectrodactyly, exhibited abnormalities was a juvenile found in several locations, notably in brachydactyly, syndactyly, polydactyly, frog captured on 16 November 1921 North America (Helgen et al., 1998; clinodactyly), the back-bone (scoli- from Bogor without one leg (amelia) Ouellet, 2000). The only report on the osis), the eyes (anophthalmy) and the (ID057.10).
    [Show full text]
  • Differential Diagnosis of Oromandibular Limb Hypogenesis Syndromes Ole Junga,B, Ralf Smeetsb, Henning Hankenb, Reinhard E
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Jun; 160(2):310-315. A patient with Charlie M Syndrome: Differential diagnosis of Oromandibular Limb Hypogenesis Syndromes Ole Junga,b, Ralf Smeetsb, Henning Hankenb, Reinhard E. Friedrichb, Max Heilandb, Amir Tagnihaa, Brian Labowa Aim. In order to provide adequate treatment to a patient with a subtype of Oromandibular Limb Hypogenesis Syndromes (OLHS), this study aimed to review and to analyze the current literature and treatment options of OLHS. Methods. Literature review in PubMed and Sciencedirect. Due to the small number of results, all available references were analyzed precisely. Results. Cases of OLHS are formerly rare and often incomplete. There are various classifications available, which, however, often seem confusing and are of little practical relevance. Furthermore, we present a complete case report of a patient with Charlie M syndrome, a type IV (Chicarilli)/ V (Hall) OLHS malformation. We also describe embryologic pathogenesis and differential diagnoses. Conclusion. As a result of our literature review, we recommend an adjusted classification for OLHS. Key words: Oromandibular Limb Hypogenesis Syndromes (OLHS), Charlie M Syndrome, Oromandibular and limb hypogenesis malformations (OLHM) Received: August 1, 2015; Accepted with revision: April 8, 2016; Available online: April 27, 2016 http://dx.doi.org/10.5507/bp.2016.020 aDepartment of Plastic and Oral Surgery, Children´s Hospital Boston, Harvard Medical School, Boston, USA bDepartment of Oral and Maxillofacial Surgery, University Medical Center Hamburg, Hamburg, Germany Corresponding author: Ole Jung, e-mail: [email protected] INTRODUCTION CASE REPORT Oromandibular Limb Hypogenesis Syndromes A twenty-three-year-old male with severe oroman- (OLHS) describe a group of heterogeneous malforma- dibular and limb deformities presented for mandibular tions of the face and body.
    [Show full text]
  • Current Advances in Holt-Oram Syndrome Taosheng Huang, MD, Phd
    Current advances in Holt-Oram syndrome Taosheng Huang, MD, PhD Holt-Oram syndrome is an autosomal-dominant condition Clinical features characterized by congenital cardiac and forelimb anomalies. It Holt and Oram first described this syndrome when they is caused by mutations of the TBX5 gene, a member of the reported on a family with atrial septal defects and con- T-box family that encodes a transcription factor. Molecular genital anomalies of the thumbs [1]. Since then, about studies have demonstrated that mutations predicted to create 200 clinical papers have been published that further de- null alleles cause substantial abnormalities in both the limbs lineate the clinical features of Holt-Oram syndrome and heart, and that missense mutations of TBX5 can produce (HOS). The prevalence of HOS is 1 of 100,000 live distinct phenotypes. One class of missense mutations causes births, and it occurs with wide ethnic and geographic significant cardiac malformations but only minor skeletal distribution. Its clinical manifestations have proved to be abnormalities; others might cause extensive upper limb variable [2,3•,4•], but with complete penetrance. All pa- malformations but less significant cardiac abnormalities. tients with HOS have upper limb anomaly and about Intrafamilial variations of the malformations strongly suggest 85% to 95% have cardiac malformation. On the basis of that genetic background or modifier genes play an important these findings, the criteria for diagnosis include either role in the phenotypic expression of HOS. Efforts to the presence of cardiac malformations, conduction de- understand the intracellular pathway of TBX5 would provide a fects and radial ray abnormalities (or both) in an indi- unique window onto the molecular basis of common vidual, or the presence of radial ray abnormalities with or congenital heart diseases and limb malformations.
    [Show full text]
  • A CLINICAL STUDY of 25 CASES of CONGENITAL KEY WORDS: Ectromelia, Hemimelia, Dysmelia, Axial, Inter- LIMB DEFICIENCIES Calary
    PARIPEX - INDIAN JOURNAL OF RESEARCH Volume-7 | Issue-1 | January-2018 | PRINT ISSN No 2250-1991 ORIGINAL RESEARCH PAPER Medical Science A CLINICAL STUDY OF 25 CASES OF CONGENITAL KEY WORDS: Ectromelia, Hemimelia, Dysmelia, Axial, Inter- LIMB DEFICIENCIES calary M.B.B.S., D.N.B (PMR), M.N.A.M.S Medical officer, D.P.M.R., K.G Medical Dr Abhiman Singh University Lucknow (UP) An Investigation of 25 patients from congenital limb deficient patients who went to D. P. M. R. , K.G Medical University Lucknow starting with 2010 with 2017. This study represents the congenital limb deficient insufficient number of the India. Commonest deficiencies were Adactylia Also mid Ectromelia (below knee/ below elbow deficiency).Below knee might have been basic in male same time The following elbow for female Youngsters. No conclusive reason for the deformity might be isolated, however, A large number guardians accepted that possible exposure to the eclipse throughout pregnancy might have been those reason for ABSTRACT those deficiency. INTRODUCTION Previous Treatment Only 15 patients had taken some D. P. M. R., K.G Medical University Lucknow (UP) may be a greatest treatment, 5 underwent some surgical treatment and only 4 Also its identity or sort of Rehabilitation Centre in India. Thusly the patients used prosthesis. This indicates the ignorance or lack of limb deficient children attending this department can easily be facilities to deal with the limb deficient children. accepted as a representative sample of the total congenital limb deficiency population in the India. DEFICIENCIES The deficiencies are classified into three categories:- MATERIAL AND METHODS This study incorporates 25 patients congenital limb deficiency for 1) Axial Dysmelia where medial or lateral portion is missing lack who originated for medicine at D.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2010/0210567 A1 Bevec (43) Pub
    US 2010O2.10567A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2010/0210567 A1 Bevec (43) Pub. Date: Aug. 19, 2010 (54) USE OF ATUFTSINASATHERAPEUTIC Publication Classification AGENT (51) Int. Cl. A638/07 (2006.01) (76) Inventor: Dorian Bevec, Germering (DE) C07K 5/103 (2006.01) A6IP35/00 (2006.01) Correspondence Address: A6IPL/I6 (2006.01) WINSTEAD PC A6IP3L/20 (2006.01) i. 2O1 US (52) U.S. Cl. ........................................... 514/18: 530/330 9 (US) (57) ABSTRACT (21) Appl. No.: 12/677,311 The present invention is directed to the use of the peptide compound Thr-Lys-Pro-Arg-OH as a therapeutic agent for (22) PCT Filed: Sep. 9, 2008 the prophylaxis and/or treatment of cancer, autoimmune dis eases, fibrotic diseases, inflammatory diseases, neurodegen (86). PCT No.: PCT/EP2008/007470 erative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the S371 (c)(1), present invention relates to pharmaceutical compositions (2), (4) Date: Mar. 10, 2010 preferably inform of a lyophilisate or liquid buffersolution or artificial mother milk formulation or mother milk substitute (30) Foreign Application Priority Data containing the peptide Thr-Lys-Pro-Arg-OH optionally together with at least one pharmaceutically acceptable car Sep. 11, 2007 (EP) .................................. O7017754.8 rier, cryoprotectant, lyoprotectant, excipient and/or diluent. US 2010/0210567 A1 Aug. 19, 2010 USE OF ATUFTSNASATHERAPEUTIC ment of Hepatitis BVirus infection, diseases caused by Hepa AGENT titis B Virus infection, acute hepatitis, chronic hepatitis, full minant liver failure, liver cirrhosis, cancer associated with Hepatitis B Virus infection. 0001. The present invention is directed to the use of the Cancer, Tumors, Proliferative Diseases, Malignancies and peptide compound Thr-Lys-Pro-Arg-OH (Tuftsin) as a thera their Metastases peutic agent for the prophylaxis and/or treatment of cancer, 0008.
    [Show full text]
  • Evolution of Morphology: Modifications to Size and Pattern
    Evolution of Morphology: Modifications to Size and Pattern The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Uygur, Aysu N. 2014. Evolution of Morphology: Modifications to Size and Pattern. Doctoral dissertation, Harvard University. Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274611 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Evolution of Morphology: Modifications to Size and Pattern A dissertation presented by Aysu N. Uygur to The Division of Medical Sciences in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the subject of Genetics Harvard University Cambridge, Massachusetts May, 2014 iii © 2014 by Aysu N. Uygur All Rights Reserved iv Dissertation Advisor: Dr. Clifford J. Tabin Aysu N. Uygur Evolution of Morphology: Modifications to Size and Pattern Abstract A remarkable property of developing organisms is the consistency and robustness within the formation of the body plan. In many animals, morphological pattern formation is orchestrated by conserved signaling pathways, through a process of strict spatio-temporal regulation of cell fate specification. Although morphological patterns have been the focus of both classical and recent studies, little is known about how this robust process is modified throughout evolution to accomodate different morphological adaptations. In this dissertation, I first examine how morphological patterns are conserved throughout the enourmous diversity of size in animal kingdom.
    [Show full text]
  • Four Unusual Cases of Congenital Forelimb Malformations in Dogs
    animals Article Four Unusual Cases of Congenital Forelimb Malformations in Dogs Simona Di Pietro 1 , Giuseppe Santi Rapisarda 2, Luca Cicero 3,* , Vito Angileri 4, Simona Morabito 5, Giovanni Cassata 3 and Francesco Macrì 1 1 Department of Veterinary Sciences, University of Messina, Viale Palatucci, 98168 Messina, Italy; [email protected] (S.D.P.); [email protected] (F.M.) 2 Department of Veterinary Prevention, Provincial Health Authority of Catania, 95030 Gravina di Catania, Italy; [email protected] 3 Institute Zooprofilattico Sperimentale of Sicily, Via G. Marinuzzi, 3, 90129 Palermo, Italy; [email protected] 4 Veterinary Practitioner, 91025 Marsala, Italy; [email protected] 5 Ospedale Veterinario I Portoni Rossi, Via Roma, 57/a, 40069 Zola Predosa (BO), Italy; [email protected] * Correspondence: [email protected] Simple Summary: Congenital limb defects are sporadically encountered in dogs during normal clinical practice. Literature concerning their diagnosis and management in canine species is poor. Sometimes, the diagnosis and description of congenital limb abnormalities are complicated by the concurrent presence of different malformations in the same limb and the lack of widely accepted classification schemes. In order to improve the knowledge about congenital limb anomalies in dogs, this report describes the clinical and radiographic findings in four dogs affected by unusual congenital forelimb defects, underlying also the importance of reviewing current terminology. Citation: Di Pietro, S.; Rapisarda, G.S.; Cicero, L.; Angileri, V.; Morabito, Abstract: Four dogs were presented with thoracic limb deformity. After clinical and radiographic S.; Cassata, G.; Macrì, F. Four Unusual examinations, a diagnosis of congenital malformations was performed for each of them.
    [Show full text]
  • Wo 2009/039966 A2
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date PCT (10) International Publication Number 2 April 2009 (02.04.2009) WO 2009/039966 A2 (51) International Patent Classification: (74) Agent: ARTH, Hans-Lothar; ABK Patent Attorneys, Jas- A61K 38/17 (2006.01) A61P 11/00 (2006.01) minweg 9, 14052 Berlin (DE). A61K 38/08 (2006.01) A61P 25/28 (2006.01) A61P 31/20 (2006.01) A61P 31/00 (2006.01) (81) Designated States (unless otherwise indicated, for every A61P 3/00 (2006.01) A61P 35/00 (2006.01) kind of national protection available): AE, AG, AL, AM, A61P 9/00 (2006.01) A61P 37/00 (2006.01) AO, AT,AU, AZ, BA, BB, BG, BH, BR, BW, BY,BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, (21) International Application Number: EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, PCT/EP2008/007500 IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY,MA, MD, ME, MG, MK, MN, MW, (22) International Filing Date: MX, MY,MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, 9 September 2008 (09.09.2008) RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY,TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (25) Filing Language: English ZW (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, 07017754.8 11 September 2007 (11.09.2007) EP ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European (AT,BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, (71) Applicant (for all designated States except US): MONDO- FR, GB, GR, HR, HU, IE, IS, IT, LT,LU, LV,MC, MT, NL, BIOTECH LABORATORIES AG [LLLI]; Herrengasse NO, PL, PT, RO, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, 21, FL-9490 Vaduz (LI).
    [Show full text]
  • Appendix 3.1 Birth Defects Descriptions for NBDPN Core, Recommended, and Extended Conditions Updated March 2017
    Appendix 3.1 Birth Defects Descriptions for NBDPN Core, Recommended, and Extended Conditions Updated March 2017 Participating members of the Birth Defects Definitions Group: Lorenzo Botto (UT) John Carey (UT) Cynthia Cassell (CDC) Tiffany Colarusso (CDC) Janet Cragan (CDC) Marcia Feldkamp (UT) Jamie Frias (CDC) Angela Lin (MA) Cara Mai (CDC) Richard Olney (CDC) Carol Stanton (CO) Csaba Siffel (GA) Table of Contents LIST OF BIRTH DEFECTS ................................................................................................................................................. I DETAILED DESCRIPTIONS OF BIRTH DEFECTS ...................................................................................................... 1 FORMAT FOR BIRTH DEFECT DESCRIPTIONS ................................................................................................................................. 1 CENTRAL NERVOUS SYSTEM ....................................................................................................................................... 2 ANENCEPHALY ........................................................................................................................................................................ 2 ENCEPHALOCELE ..................................................................................................................................................................... 3 HOLOPROSENCEPHALY.............................................................................................................................................................
    [Show full text]
  • Appendix 3.1 Birth Defects Descriptions for NBDPN Core, Recommended, and Extended Conditions Updated March 2021
    Appendix 3.1 Birth Defects Descriptions for NBDPN Core, Recommended, and Extended Conditions Updated March 2021 Participating members of the Birth Defects Definitions Group: Lorenzo Botto (UT) John Carey (UT) Cynthia Cassell (CDC) Tiffany Colarusso (CDC) Janet Cragan (CDC) Marcia Feldkamp (UT) Jamie Frias (CDC) Angela Lin (MA) Cara Mai (CDC) Richard Olney (CDC) Carol Stanton (CO) Csaba Siffel (GA) Appendix 3.1 A3.1-1 Case Definition Table of Contents LIST OF BIRTH DEFECTS ................................................................................................................................. I DETAILED DESCRIPTIONS OF BIRTH DEFECTS ....................................................................................... 1 FORMAT FOR BIRTH DEFECT DESCRIPTIONS ......................................................................................................................... 1 CENTRAL NERVOUS SYSTEM ........................................................................................................................ 2 ANENCEPHALY ............................................................................................................................................................... 2 ENCEPHALOCELE ............................................................................................................................................................ 3 HOLOPROSENCEPHALY .................................................................................................................................................... 4
    [Show full text]
  • Treatment Posibilities in Ectromelia
    PRIKAZI BOLESNIKA BIBLID: 0370-8179, 135(2007) 5-6, p. 346-351 UDC: 616.7-089:615.8 TREATMENT POSIBILITIES IN ECTROMELIA Dan NEMEŞ, Dan POENARU, Oana BERETEU, Roxana ONOFREI, Elena AMARICAI, Alina TOTOREAN 1”Victor Babeş” University of Medicine and Pharmacology, Timisoara, Romania; 2City Universitary and Emergency Hospital-Rehabilitation and Rheumatology Department, Timisoara, Romania; 3Timis County Universitary and Emergency Hospital-II Orthopaedic and Traumatology Department, Timisoara, Romania; 4Timis County Universitary and Emergency Hospital-II Orthopaedic and Traumatology Department, Rehabilitation Department, Timisoara, Romania SUMMARY Introduction Ectromelia is a congenital abnormality characterised by limb growth disturbances (aplasia or hypoplasia) dur- ing the period from 4th to 8th gestation week. Case outline We present a case of hemimezomelic longitudinal ectromelia of the right upper limb associated with other skel- etal abnormalities, surgically treated. An important role in the management of this case is attributed to the complex rehabili- tation programme done before and after each surgical intervention. Conclusion The aim of the complex therapy is to diminish the permanent invalidity of these patients. Key words: ectromelia; surgical treatment; functional rehabilitation INTRODUCTION months of pregnancy. At the age of two, the patient was admitted to the Children’s Clinic with bronchopneumo- Ectromelia is defined as a congenital development nia, anaemia, nutritional dystrophy and plurimalforma- anomaly characterised by limb growth disturbances tive syndrome, treated for a long period with intramus- (aplasia or hypoplasia) or by limb amputations due to cular antibiotics. amniotic liquid insufficiency [1]. This report describes Examination showed growth retardation (height – a case of ectromelia and tries to analyse the efficiency of 125 centimetres, weight – 32 kilogrammes); macrotia, a complex treatment.
    [Show full text]
  • XI. COMPLICATIONS of PREGNANCY, Childbffith and the PUERPERIUM 630 Hydatidiform Mole Trophoblastic Disease NOS Vesicular Mole Ex
    XI. COMPLICATIONS OF PREGNANCY, CHILDBffiTH AND THE PUERPERIUM PREGNANCY WITH ABORTIVE OUTCOME (630-639) 630 Hydatidiform mole Trophoblastic disease NOS Vesicular mole Excludes: chorionepithelioma (181) 631 Other abnormal product of conception Blighted ovum Mole: NOS carneous fleshy Excludes: with mention of conditions in 630 (630) 632 Missed abortion Early fetal death with retention of dead fetus Retained products of conception, not following spontaneous or induced abortion or delivery Excludes: failed induced abortion (638) missed delivery (656.4) with abnormal product of conception (630, 631) 633 Ectopic pregnancy Includes: ruptured ectopic pregnancy 633.0 Abdominal pregnancy 633.1 Tubalpregnancy Fallopian pregnancy Rupture of (fallopian) tube due to pregnancy Tubal abortion 633.2 Ovarian pregnancy 633.8 Other ectopic pregnancy Pregnancy: Pregnancy: cervical intraligamentous combined mesometric cornual mural - 355- 356 TABULAR LIST 633.9 Unspecified The following fourth-digit subdivisions are for use with categories 634-638: .0 Complicated by genital tract and pelvic infection [any condition listed in 639.0] .1 Complicated by delayed or excessive haemorrhage [any condition listed in 639.1] .2 Complicated by damage to pelvic organs and tissues [any condi- tion listed in 639.2] .3 Complicated by renal failure [any condition listed in 639.3] .4 Complicated by metabolic disorder [any condition listed in 639.4] .5 Complicated by shock [any condition listed in 639.5] .6 Complicated by embolism [any condition listed in 639.6] .7 With other
    [Show full text]