Alfatravel.Co.Uk | 01257 248000 Welcome to the ALFA TRAVEL BROCHURE

Total Page:16

File Type:pdf, Size:1020Kb

Alfatravel.Co.Uk | 01257 248000 Welcome to the ALFA TRAVEL BROCHURE DEPARTING UK, FROM IRELAND NORTH & EUROPE WEST &Coach SELF DRIVE Holidays BREAKS CELEBRATING CELEBRATING 30YEARS 30YEARS November 2019 - December 2020 The UK’s only Employee Owned Travel Company alfatravel.co.uk | 01257 248000 Welcome to the ALFA TRAVEL BROCHURE Hello… and a warm Alfa welcome to our Whether you choose to sit back and take in NEW Summer 2020 brochure, featuring the stunning vistas from the comfort of your a handpicked collection of holidays to personal, luxury seat on our coach breaks, CELEBRATING the UK’s finest seaside destinations in cruise down the Rhine aboard your very own partnership with our very own Leisureplex floating hotel without the need to pack and hotels, with amazing ‘value added’ unpack every day or you simply prefer to excursions and seasonal offers – experience the freedom to go as you please all designed to tempt you away! on our self drive breaks in your own car, 30YEARS you’re always assured of the same great Alfa Your very own team of Alfa memory makers hospitality. have been busy designing a fantastic new With lots of single rooms available, no hidden range of holiday experiences within the UK charges for seats or pick ups and a fantastic and Europe especially with our customers in range of 21 destinations to choose from mind. Working with our carefully selected Alfa MICK with Leisureplex hotels, plus a whole host of LAMBERT preferred partners, our unique range of tours tempting partner breaks across the UK and Alfa Driver take in some of the UK and Europe’s ‘must see’ of the Year Europe, what more reason do you need to destinations from the world-famous to those get away? magical ‘hidden gems’. Here at Alfa, we are proud to be part of the In 2020 we are celebrating 30 years of Alfa Alfa Leisureplex Group, the only employee Travel delivering award winning holidays. Our owned travel company within the UK, so experience and heritage means we are truly whether you have travelled with us before or trusted by our customers who book with us are looking to holiday with us for the first time, again and again, and as an employee owned we look forward to welcoming you on board business that’s something that makes us all in 2020 and thank you for your continued very proud. support. We also pride ourselves on offering the widest Best wishes, the Alfa Team range of ways to join your holiday. 2 Call 01257 248000, visit alfatravel.co.uk or visit your local travel agent Celebrating 30 years of Alfa travel YOUR HOLIDAY CHOICE UK, IRELAND AND EUROPE Introduction to Alfa 2 NEW Cambridgeshire 57 Events 7 Oxford, Stratford & Cotswolds 58 Castles of the Malverns & Cotswolds 58 Cabaret Weekends 8 Severn & Wye Rivers & Railways 58 Reunion Breaks 8 WALES 59 Away Resorts 9 Llandudno 60 Easter Weekenders 10 Criccieth 62 Themed Evenings 11 Tenby 64 Shropshire To The Sea Spring Breaks 12 65 Porthcawl 66 SOUTH WEST ENGLAND 14 Sidmouth 14 SCOTLAND 68 Ilfracombe 15 Aberdeen 68 BOOKING WITH ALFA Weston-super-Mare 16 Fort William 69 Bath, Salisbury & The Cotswolds 17 Dunoon 70 MADE EASY Newquay 18 Royal Deeside 72 Bideford 19 Highland Highlights 73 NEW Teignmouth 19 Glasgow & Edinburgh 74 BOOK AT YOUR CONVENIENCE Torquay 20 Loch Lomond & The Falkirk Wheel 74 Exmouth 22 Oban & Mull 75 ON OUR WEBSITE Ullapool 75 SOUTH & SOUTH EAST ENGLAND 23 IRELAND 76 alfatravel.co.uk Bournemouth 24 NEW County Cork 76 Weymouth 26 Killarney & Scenic Co. Kerry 76 Why not search and book your holiday from the comfort of Isle of Wight - Sandown 27 County Clare & Galway 77 Isle of Wight - Shanklin 28 NEW Waterford 77 your own home. Bognor Regis 30 NEW Wild Atlantic Way & Connemara 78 Eastbourne 32 Belfast & Giant’s Causeway 78 Call our friendly reservations team on 01257 248000 Kent 34 EUROPE 79 Folkestone 35 Austrian Tyrol 79 Our offices are open: Brighton 36 Belgian Coast 80 Canterbury & Chatham 36 Mon – Fri: 08.30 am – 6.30 pm (New extended hours) Dutch Bulbfields 80 NEW London & Kew Gardens 37 Belgium 81 Sat: 09.00 am – 5.00 pm, Margate 37 Flanders Fields & The Somme 81 Wartime Britain 38 Sundays & Bank Holidays: 10 am – 4.00 pm Dordogne 82 Oxford & Cambridge 38 Annecy & French Alps 82 Visit an approved Travel Agent EAST COAST ENGLAND 39 Black Forest & Alsace 82 Great Yarmouth 40 Treasures of Tuscany 83 We have an extensive range of partner travel agents within your Cromer 42 NEW Lake Garda 83 local area, who will be able to guide you through your booking. Southend on Sea 43 NEW Lake Maggiore 83 Skegness 44 RIVER CRUISE NORTH EAST ENGLAND 45 NEW Spring Gardens 84 Scarborough 46 NEW Seine Paris to Honfleur 85 NEW York, Harrogate and NEW Rhine 86 Castle Howard 47 NEW Danube 87 NEW Bridlington 48 JERSEY BY AIR 88 Northumbria & Beamish 49 PEACE OF MIND Preferred Partners 89 NORTH WEST ENGLAND 50 Autumn Breaks 90 We are fully bonded tour operator members of the Association of British Lytham St. Annes 51 Southport 51 Festive Season 92 Travel Agents, so you can be sure that all payments made to us in advance of Blackpool 52 Joining Your Tour 94 your holiday are fully protected. In addition, as an ABTA member we adhere to Lake District 54 Self Drive Hotel Breaks 96 Isle of Man 55 a strict code of conduct. For more information on ABTA, the Code of Conduct Super Savers 99 CENTRAL ENGLAND 56 Group Holidays 100 and the arbitration scheme available to you if you have a complaint, contact Warwick Castle & The Cotswolds 56 ABTA, 30 Park Street, London SE1 9EQ. Derbyshire Dales 57 Holiday Insurance 100 Nottingham 57 Booking Conditions 101 Tel 020 3117 0500. www.abta.com. 30 30 Call 01257 248000, visit alfatravel.co.uk or visit your local travel agent YEARS Celebrating 30 years of Alfa travel YEARS 3 HOLIDAY WITH US... EXPERIENCE THE ALFA DIFFERENCE Here at Alfa, we are passionate about offering the very widest choice of coach holidays, featuring exclusive itineraries and unique experiences. The majority of our coach holidays include free excursions and admissions to some of the UK and Europe’s most fascinating places without the need to pre book yourself or queue at busy times of the year. EXPLORE THE VERY BEST OF THE BRITISH A fantastic team of employee owner knowledgeable drivers are on SEASIDE WITH LEISUREPLEX HOTELS hand to share with you their ‘hidden secrets’ and top tips to help you From a warm welcome on arrival to the very last minute of your holiday, our get the most out of your holiday. helpful team will be on hand to make your stay one to remember. Our quality hotels are matched by professional, efficient staff representing the very best of HOTEL ICON KEY the UK hospitality industry. Keep a look out for the icon keys throughout the brochure which will Set in some of the very best iconic seaside resorts, many of our hotels offer help you to easily identify which facilities are available at your chosen stunning views and the perfect location from which to take an evening stroll or hotel. explore the delights of the local town. 117 Leisureplex hotels have entertainment on at least four evenings and up to six evenings per week included. All our hotels are large enough to provide both cosy The hotel Entertainment Tea/Coffee WiFi at least The number of relaxing lounge areas where you can enjoy a tranquil glass of wine or curl up has a lift on at least one facilities in in the public bedrooms in evening bedroom areas the hotel with a book and fabulous entertainment areas if you fancy a spin around the dance floor or being entertained with a cabaret act. ENJOY YOUR STAY THE ALFA WAY All the hotels featured in our brochure are handpicked by our resident team of Alfa product curators to ensure that you get the most out of your holiday. Many of our UK holidays stay at our own group of Leisureplex Hotels which are highlighted throughout the brochure with the logo. GRADE DESCRIPTION Good standard of accommodation, perhaps with self-service restaurant or limited entertainment Very good standard of accommodation, equivalent to 2 or 3 star standard, with choice of menu and usually entertainment Excellent accommodation, superb facilities and high standard of catering Superb accommodation, offering exquisite service and cuisine. 4 Call 01257 248000, visit alfatravel.co.uk or visit your local travel agent GREAT HOTELS IN GREAT LOCATIONS All hotels featured are in superb locations and are perfectly placed to ensure you make the most of the region you’re visiting. Most holidays are to our own group of 22 Leisureplex Hotels, which are highlighted DINING IN LEISUREPLEX HOTELS in our brochure with the symbol and we also work with a We provide a full british breakfast to start off the day and in the evening selection of carefully chosen partner hotels. you can relax with our substantial menus which offer plenty of choice and a selection of wines. Light two course lunches are included on some Spring and Autumn holidays or you can take advantage of our great value meal deal, where we can provide a picnic lunch for you to enjoy on your travels. We can accommodate most dietary requirements. Please call our dedicated Special Requirements line on 01257 248134. CATERING FOR YOUR NEEDS If you have a Special Request please let us know at the time you confirm your booking. Although we cannot guarantee that we will be able to meet your request, we will always do our best to facilitate where possible.
Recommended publications
  • Tobacco Labelling -.:: GEOCITIES.Ws
    Council Directive 89/622/EC concerning the labelling of tobacco products, as amended TAR AND NICOTINE CONTENTS OF THE CIGARETTES SOLD ON THE EUROPEAN MARKET AUSTRIA Brand Tar Yield Nicotine Yield Mg. Mg. List 1 A3 14.0 0.8 A3 Filter 11.0 0.6 Belvedere 11.0 0.8 Camel Filters 14.0 1.1 Camel Filters 100 13.0 1.1 Camel Lights 8.0 0.7 Casablanca 6.0 0.6 Casablanca Ultra 2.0 0.2 Corso 4.0 0.4 Da Capo 9.0 0.4 Dames 9.0 0.6 Dames Filter Box 9.0 0.6 Ernte 23 13.0 0.8 Falk 5.0 0.4 Flirt 14.0 0.9 Flirt Filter 11.0 0.6 Golden Smart 12.0 0.8 HB 13.0 0.9 HB 100 14.0 1.0 Hobby 11.0 0.8 Hobby Box 11.0 0.8 Hobby Extra 11.0 0.8 Johnny Filter 11.0 0.9 Jonny 14.0 1.0 Kent 10.0 0.8 Kim 8.0 0.6 Kim Superlights 4.0 0.4 Lord Extra 8.0 0.6 Lucky Strike 13.0 1.0 Lucky Strike Lights 9.0 0.7 Marlboro 13.0 0.9 Marlboro 100 14.0 1.0 Marlboro Lights 7.0 0.6 Malboro Medium 9.0 0.7 Maverick 11.0 0.8 Memphis Classic 11.0 0.8 Memphis Blue 12.0 0.8 Memphis International 13.0 1.0 Memphis International 100 14.0 1.0 Memphis Lights 7.0 0.6 Memphis Lights 100 9.0 0.7 Memphis Medium 9.0 0.6 Memphis Menthol 7.0 0.5 Men 11.0 0.9 Men Light 5.0 0.5 Milde Sorte 8.0 0.5 Milde Sorte 1 1.0 0.1 Milde Sorte 100 9.0 0.5 Milde Sorte Super 6.0 0.3 Milde Sorte Ultra 4.0 0.4 Parisienne Mild 8.0 0.7 Parisienne Super 11.0 0.9 Peter Stuyvesant 12.0 0.8 Philip Morris Super Lights 4.0 0.4 Ronson 13.0 1.1 Smart Export 10.0 0.8 Treff 14.0 0.9 Trend 5.0 0.2 Trussardi Light 100 6.0 0.5 United E 12.0 0.9 Winston 13.0 0.9 York 9.0 0.7 List 2 Auslese de luxe 1.0 0.1 Benson & Hedges 12.0 1.0 Camel 15.0 1.0
    [Show full text]
  • Agentschap Plantentuin Meise Jaarverslag Rapport Annuel Annual Report 2017
    Agentschap Plantentuin Meise Jaarverslag Rapport annuel Annual report 2017 Agentschap Plantentuin Meise Jaarverslag Rapport annuel Annual report 2017 4 – 5 Voorwoord Avant-propos Foreword 6 – 7 Inleiding Introduction Introduction 9 – 24 Biodiversiteit ontdekken en optekenen Découvrir et inventorier la biodiversité Discovering and recording biodiversity 25 – 33 Ecosystemen begrijpen Comprendre les écosystèmes Understanding ecosystems 34 – 46 Plantendiversiteit veiligstellen Préserver le monde végétal Safeguarding plant life 47 – 62 Ons patrimonium valoriseren Valoriser notre patrimoine Bringing our heritage to life 63 – 74 Taxonomie voor de toekomst Taxonomie pour le futur Taxonomy for the future 75 – 88 99 – 104 Inspireren en informeren Organisatie Inspirer et informer Organisation Inspiring and informing Organisation 89 – 98 105 – 125 Realiseren van state-of-the-art bezoekers- De Plantentuin in cijfers en onderzoeksinfrastructuur Le Jardin botanique en chiffres Développer une infrastructure de pointe Facts and figures pour les visiteurs et la recherche Realising state-of-the-art visitor and 126 – 131 research infrastructure Publicaties Publications Publications 132 – 134 Het Plantentuinteam L’équipe du Jardin The Garden’s team 135 – 139 Plantentuin Meise in een notendop Le Jardin botanique de Meise en quelques mots Meise Botanic Garden, a portrait Voorwoord Moderne botanische tuinen moeten openstaan voor de bezoekers en beant- woorden aan hun vragen en verzuchtin- gen. Door de realisatie van het masterplan zal Plantentuin Meise in de volgende tien jaar grondig van uitzicht veranderen en zijn publiek gaandeweg steeds beter kun- nen dienen. Uit dit jaarverslag blijkt dat de eerste grote veranderingen in 2017 zichtbaar werden, maar de ontwikkelingen gaan in een snel tempo door. In 2018 en 2019 wor- den de twee ingangen vernieuwd, waarna ze zullen beantwoorden aan alle noden: verbeterde ticketverkoop, toiletten, plantentuinwinkel, bewegwijzering, een verbeterde uitleendienst voor rolstoelen, enz.
    [Show full text]
  • A Special Report from Oil and Gas Investor and Global Business Reports
    Mexico A Special Report From Oil and Gas Investor and Global Business Reports Photo courtesy of Nabors. MEXICO OIL AND GAS Mexico’s Energy Reform: an opportunity in three generations Mexico’s oil production has decreased from 3.4 MMbbl/d in 2004 to 2.4 MMbbl/d today. Photo courtesy of Pemex. onday August 11,, 2014, represented historic mo- ation was not sustainable; a steep decrease in oil prices over ment for Mexico: President Enrique Peña Nieto, the second half of 2014 has only helped the cause of those M who brought the Institutional Revolutionary Par- advocating for the reform. “What closes the circle of the re- ty (PRI) back into power in 2012, signed the Energy Reform form is that, although the Mexican state will no longer keep bill after the legislative powers approved the secondary laws 100% of the oil income, total revenues from the hydrocar- that will develop the new framework. bons sector will increase because production volumes will be By the end of October, the details of the 25 sets of rules higher,” explained Fluvio César Ruiz Alarcón, independent transforming the country’s model for the oil and gas and board member of Pemex. electricity sectors had already been published by the Mexi- The expectation is to reach 3 MMbbl/d by 2018, al- can administration. The process is developing at quite a fast though Ruiz Alarcón believes that timing to be overambi- pace considering that this is landmark reform that involves tious: “To add production to a 76-year-old structure will constitutional change and ends the 76-year monopoly in ex- take longer,” he said.
    [Show full text]
  • Iniezioneiniezione the Newsletter of the Northwest Alfa Romeo Club
    IniezioneIniezione The newsletter of the Northwest Alfa Romeo Club “Barn Find” at Alfa of Tacoma It was about a week before the Half-fast Lap last September when my friend, Steve Anderson (now a new club member) called, so excited about a “barn find” he had heard about that he couldn’t even wait for me to finish my shower. An uncle, Steve Bates, had been to his house for dinner the night before, and had told of a 1957 Alfa spider that his brother-in-law had taken to Alfa of Tacoma for repairs in 1977 and never picked up. Steve B’s brother-in-law, Phil George, had lived in Richland and acquired the car in about 1967. Steve remembers that Phil drove the car actively, and on one particular “hold on tight” ride, Phil told him that he and the Alfa “became one” when he drove. Steve had his doubts. When the engine began to show problems, Phil brought it to Alfa of Tacoma. Carlo ended up rebuilding the top and bottom ends, the front suspension, the brakes, and replaced the steering box. Carlo knew the car and said Phil had always taken good care of it, but when it came time to pick it up, he couldn’t pay for it. He stopped by often to see it, though. Phil remarried, but his new wife thought he really didn’t need that car, so there it sat, in the second bay from the window, on jack stands and under a cover. Phil died about five years ago and Lino had no idea how to contact any of the family.
    [Show full text]
  • Kohls Santa Claus Event
    Kohls Santa Claus Event heLet-out distrusts Franklyn so openly. counterplotted Dreamier acutely Wilhelm while sometimes Daren always debag externalizesany Lalage gazed his lactase levelling. invokes Beamless yestreen, Axel chock.plane or canings some steerers tenth, however madrigalian Marcio propound higgledy-piggledy or When he would join hands with many retailers to help them their children heard from that are tax deductible through our customers. Want to the website uses cookies and makes for setting up against santa claus at nj. Each created a santa claus can reach the events are posted online donation system is holding its fashion designer and assistance to. The exact date will last week, fun and pick out masks at stores. Get instant email, bought presents in a physical stores this is wearing santa? Claus make it comes santa claus was this event is revealed to make reindeer. Get ready to a variety of animal at all the basic instruction, raritan and join fan following retailers are speed, see what better than one! The santa claus to the techniques that exploit the holiday bag, an incorrect email address will run one! This deception is a merry christmases because he became the comments are provided to bring your phone calls the storm was made history as a coconut milk is? He is santa claus some respect from and events, in the event now believe in an emerging amrican actress attributes the. We welcome your kiddos visited with santa claus as tennessee. Contact hunterdon county news keeps him by a variety of public health authority for? Apple said in santa claus, the event for friday special mailbox and local news, shauna and highly.
    [Show full text]
  • Past and Present Alfa 2-6-03
    PAST AND PRESENT 2/6/2003 NAME/TOWN SUBJECT DATE PAGE # A. A. Grinnell Co. Incorporated 1899 58 A. A. Grinnell Co. Bought lumber rights 1909 201 A. A. Grinnell Co. Bought land 1910 212 A. G. Henning Foreign currency display 5-16-1931 115 A. J. Tanner Canning Company Fly wheel accident 1906 127 Acheson, Edward G. Associate of Frank J. Tone 10-3-1931 157 Acker, George Eats peaches he sent brother 27yrs ago 9-28-1901 8 Ackley, Zebulon Early purchaser of land fm Holland Land Co 1-5-1929 34 Acquard, Mrs. Anna Barn burned 1941 253 Adair, Mrs. A. R. Hen lays odd egg 11-24-1934 184 Adams, Augustus Running for office 1899 55 Adams, M. B. In old copy of The Daily Morning News 11-10-1934 192 Adams, Parmenio Short biography 3-31-1928 30 Adams, Parmenus Surveyed Telephone Rd. in Alexander 8-15-1931 142 Adams, Ralph Member of hunting party 11-22-1930 99 Adams, Rev. John R. Left Batavia 1911 143 Adams, Rev. John R. Campaign for no-license 1909 210 Aderman, W. Price Fined for tie remark 1-11-1947 260 Ahl, Mrs. George Found large mushrooms 10-17-1931 161 Akron Birds destroy power transformer 7-25-1931 137 Akron Built water plant 1926 174 Akron Man killed by train 1898 207 Akron Reservation resident got stuffed alligator 1-17-1925 227 Akron New Indian schools superintendent 1905 239 Akron Hen laid large egg 3-23-1946 243 Akron Typhoid epidemic 1926 253 Akron Typhoid epidemic 1921 256 Akron Typhoid epidemic 1926 257 Akron Employees picket 1937 266 Akron Strike near ended 1937 269 Alabama Carp beached in flood 1901 114 Alabama Only town without rural mail delivery 1901 120 Alabama Niagara Gypsum Co.
    [Show full text]
  • Jaarverslag 2018, Plantentuin Meise Rapport Annuel 2018, Jardin Botanique De Meise Annual Report 2018, Meise Botanic Garden Agentschap Plantentuin Meise
    Jaarverslag 2018, Plantentuin Meise Rapport annuel 2018, Jardin botanique de Meise Annual report 2018, Meise Botanic Garden Agentschap Plantentuin Meise Jaarverslag 2018 Rapport annuel Annual report 4 – 5 Voorwoord Avant-propos Foreword 6 – 7 Inleiding Introduction Introduction 9 – 26 Biodiversiteit ontdekken en optekenen Découvrir et inventorier la biodiversité Discovering and recording biodiversity 27 – 30 Ecosystemen begrijpen Comprendre les écosystèmes Understanding ecosystems 31 – 38 Plantendiversiteit veiligstellen Préserver le monde végétal Safeguarding plant life 39 – 54 Ons patrimonium valoriseren Valoriser notre patrimoine Bringing our heritage to life 55 – 62 Taxonomie voor de toekomst Taxonomie pour le futur Taxonomy for the future 63 – 76 85 – 96 Inspireren en informeren Organisatie Inspirer et informer Organisation Inspiring and informing Organisation 77 – 84 97 – 119 Realiseren van state-of-the-art bezoe- De Plantentuin in cijfers kers- en onderzoeksinfrastructuur Le Jardin botanique en chiffres Développer une infrastructure de pointe Facts and fi gures pour les visiteurs et la recherche Realising state-of-the-art visitor and 120 – 124 research infrastructure Publicaties Publications Publications 126 – 128 Het Plantentuinteam L’équipe du Jardin The Garden’s team 129 – 133 Plantentuin Meise in een notendop Le Jardin botanique de Meise en quelques mots Meise Botanic Garden, a portrait Voorwoord Plantentuin Meise is een multidisciplinair insti­ tuut dat zich zowel richt tot het brede publiek als tot de onderzoeksgemeenschap. Collecties zijn de basis van onze onderzoeksactiviteiten. Het betreft levende planten, herbariumspeci­ mens, specimens op bewaarvloeistof en, in toenemende mate, DNA van planten. Herbaria bezitten miljoenen plantenspecimens die over meerdere eeuwen verzameld werden; ze zijn een ongeëvenaarde getuige van de mondiale biodiversiteit.
    [Show full text]
  • Exclusion List
    Exclusion list ROBECO INSTITUTIONAL ASSET MANAGEMENT 1 Sustainability Inside Excluded companies: 61 Rimbunan Sawit Bhd 15 Bots Inc 62 Riverview Rubber Estates BHD 16 Bright Packaging Industry Bhd Controversial behavior 63 Salim Ivomas Pratama Tbk PT 17 Brilliant Circle Holdings International Ltd 1 G4S International Finance PLC 64 Sarawak Oil Palms Bhd 18 British American Tobacco Bangladesh Co Ltd 2 G4S PLC 65 Sarawak Plantation Bhd 19 British American Tobacco Chile Operaciones SA 3 Korea Electric Power Corp 66 Scope Industries Bhd 20 British American Tobacco Holdings The Netherlands BV 4 Oil & Natural Gas Corp Ltd1 67 Sin Heng Chan Malaya Bhd 21 British American Tobacco Kenya PLC 5 ONGC Nile Ganga BV 68 Sinar Mas Agro Resources & Technology Tbk PT 22 British American Tobacco Malaysia Bhd 6 ONGC Videsh Ltd 69 Socfin 23 British American Tobacco PLC 7 Vale Indonesia Tbk PT 70 Socfinasia SA 24 British American Tobacco Uganda Ltd 8 Vale SA2 71 Societe Camerounaise de Palmeraies 25 British American Tobacco Zambia PLC 72 Societe des Caoutchoucs de Grand-Bereby 26 British American Tobacco Zimbabwe Holdings Ltd Palm oil 73 SSMS Plantation Holdings Pte Ltd 27 Bulgartabac Holding AD 1 A Brown Co Inc 74 Sterling Plantations Ltd 28 Carreras Ltd/Jamaica 2 Agalawatte Plantations PLC 75 Subur Tiasa Holdings Bhd 29 Casey’s General Stores Inc 3 Anglo-Eastern Plantations PLC 76 Sungei Bagan Rubber Co Malaya Bhd 30 Cat Loi JSC 4 Astra Agro Lestari Tbk PT 77 Sunshine Holdings PLC 31 Ceylon Tobacco Co PLC 5 Astral Asia Bhd 78 Ta Ann Holdings Bhd 32 Champion
    [Show full text]
  • 38 2000 Tobacco Industry Projects—A Listing (173 Pp.) Project “A”: American Tobacco Co. Plan from 1959 to Enlist Professor
    38 2000 Tobacco Industry Projects—a Listing (173 pp.) Project “A”: American Tobacco Co. plan from 1959 to enlist Professors Hirsch and Shapiro of NYU’s Institute of Mathematical Science to evaluate “statistical material purporting to show association between smoking and lung cancer.” Hirsch and Shapiro concluded that “such analysis is not feasible because the studies did not employ the methods of mathematical science but represent merely a collection of random data, or counting noses as it were.” Statistical studies of the lung cancer- smoking relation were “utterly meaningless from the mathematical point of view” and that it was “impossible to proceed with a mathematical analysis of the proposition that cigarette smoking is a cause of lung cancer.” AT management concluded that this result was “not surprising” given the “utter paucity of any direct evidence linking smoking with lung canner.”112 Project A: Tobacco Institute plan from 1967 to air three television spots on smoking & health. Continued goal of the Institute to test its ability “to alter public opinion and knowledge of the asserted health hazards of cigarette smoking by using paid print media space.” CEOs in the fall of 1967 had approved the plan, which was supposed to involve “before-and-after opinion surveys on elements of the smoking and health controversy” to measure the impact of TI propaganda on this issue.”113 Spots were apparently refused by the networks in 1970, so plan shifted to Project B. Project A-040: Brown and Williamson effort from 1972 to 114 Project AA: Secret RJR effort from 1982-84 to find out how to improve “the RJR share of market among young adult women.” Appeal would 112 Janet C.
    [Show full text]
  • 13-Cis-Retinoic Acid
    WORLD HEALTH ORGANIZATION INTERNATIONAL AGENCY FOR RESEARCH ON CANCER IARC Handbooks of Cancer Prevention Retinoids Volume 4 This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Cancer-preventive Agents, which met in Lyon, 24-30 March 1999 Published by the International Agency for Research on Cancer, 150 cours Albert Thomas, F-69372 Lyon cedex 08, France © International Agency for Research on Cancer, 1999 Distributed by Oxford University Press, Walton Street, Oxford, 0X2 6DP, UK (Fax: +44 1865 267782) and in the USA by Oxford University Press, 2001 Evans Road, Carey, NC 27513, USA (Fax: +1 919 677 1303). All IARC publications can also be ordered directly from IARCPress (Fax: +33 4 72 73 83 02; E-mail: [email protected]). Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. All rights reserved. The designations used and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
    [Show full text]
  • Swedish Match Is a Global Group of Companies with a Broad Assortment of Market-Leading Brands in Smokeless Tobacco Products, Cigars, Pipe Tobacco and Lights Products
    ANNUAL REPORT 2006 Swedish Match is a global Group of companies with a broad assortment of market-leading brands in smokeless tobacco products, cigars, pipe tobacco and lights products. Contents Swedish Match 2006 2 This is Swedish Match Swedish Match is a global Group of companies with CEO’s comments 4 The past year a broad assortment of market-leading brands in 6 The business environment smokeless tobacco products, cigars, pipe tobacco and 8 Our strategies 10 Brand strategy lights products.The Swedish Match share is listed on the Product areas Stockholm Stock Exchange. 14 Snuff and snus 18 Cigars 22 Chewing tobacco 24 Pipe tobacco and Accessories • Sales amounted to 12,911 MSEK (13,311). 26 Lights • Operating profit increased by 15 percent, and 28 Social responsibility and the environment amounted to 3,235 MSEK (2,825). 32 Human Resources • Operating profit excluding larger one time 36 Report of the Board of Directors Consolidated Financial items amounted to 3,087 MSEK (2,618). Statements • Operating margin for the Group grew to 40 Income Statement 41 Balance Sheet 23.9 percent (19.7). 42 Changes in Statement of Equity • EPS (basic) was 8.12 SEK (5.61). 43 Cash Flow Statement 44 Notes for the Group • The Board proposes an increased dividend to Parent Company Financial 2.50 SEK (2.10). Statements 68 Income Statement 69 Balance Sheet 70 Changes in Equity 71 Cash Flow Statement Key data, MSEK 2006 2005 2004 72 Notes for the Parent Company Net sales 12,911 13,311 13,007 78 Proposed distribution of earnings EBITDA excluding larger one time items 3,533 3,206 2,916 79 Auditors’ report Operating profit 3,235 2,825 3,593 Corporate Governance Operating margin, % 23.9 19.7 17.8 80 Corporate Governance report Profit for the year 2,331 1,777 2,084 86 Board of Directors Earnings per share, SEK 8.12 5.61 6.18 88 Group management Dividend per share, SEK 2.50* 2.10 1.90 90 Five-year summary Return on shareholders’ equity, % 63.3 36.6 48.2 92 Quarterly data * Board proposal.
    [Show full text]
  • APOE2 Mitigates Disease-Related Phenotypes in an Isogenic Hipsc- Based Model of Alzheimer’S Disease
    Molecular Psychiatry https://doi.org/10.1038/s41380-021-01076-3 ARTICLE APOE2 mitigates disease-related phenotypes in an isogenic hiPSC- based model of Alzheimer’s disease 1,2 1 1 1 1 Nicholas Brookhouser ● Sreedevi Raman ● Carlye Frisch ● Gayathri Srinivasan ● David A. Brafman Received: 11 August 2020 / Revised: 26 February 2021 / Accepted: 23 March 2021 © The Author(s) 2021. This article is published with open access Abstract Genome-wide association studies (GWAS) have identified polymorphism in the Apolipoprotein E gene (APOE) to be the most prominent risk factor for Alzheimer’s disease (AD). Compared to individuals homozygous for the APOE3 variant, individuals with the APOE4 variant have a significantly elevated risk of AD. On the other hand, longitudinal studies have shown that the presence of the APOE2 variant reduces the lifetime risk of developing AD by 40 percent. While there has been significant research that has identified the risk-inducing effects of APOE4, the underlying mechanisms by which APOE2 influences AD onset and progression have not been extensively explored. In this study, we utilize an isogenic human induced pluripotent stem cell (hiPSC)-based system to demonstrate that conversion of APOE3 to APOE2 greatly reduced the β 1234567890();,: 1234567890();,: production of amyloid-beta (A ) peptides in hiPSC-derived neural cultures. Mechanistically, analysis of pure populations of neurons and astrocytes derived from these neural cultures revealed that mitigating effects of APOE2 are mediated by cell autonomous and non-autonomous effects. In particular, we demonstrated the reduction in Aβ is potentially driven by a mechanism related to non-amyloidogenic processing of amyloid precursor protein (APP), suggesting a gain of the protective function of the APOE2 variant.
    [Show full text]