Module 3 Basics of Growing Up- Understanding Adolescence
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Novel Ways of Assessing Puberty
NOVEL WAYS OF ASSESSING PUBERTY Findings from the Adolescent Rural Cohort Study of Hormones, Health, Education, Environments and Relationships Ben W.R. Balzer B.Med.Sc., M.B., B.S. (Syd.) A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy Discipline of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney Primary Supervisor: Professor Katharine S. Steinbeck Medical Foundation Chair in Adolescent Medicine, The University of Sydney 2019 STATEMENT OF AUTHENTICATION This thesis is submitted to the University of Sydney in fulfilment of the requirement is for the Degree of Doctor of Philosophy. The work presented in this thesis is, to the best of my knowledge and belief, original except as acknowledged in the text. I hereby declare that I have not submitted this material, either in full or in part, for a degree at this or any other institution. Signature: Ben W.R. Balzer Date: 3 June 2019 i ACKNOWLEDGEMENTS I would like to thank Professor Kate Steinbeck for her role as my primary supervisor. I have worked with Kate since 2010, when I first joined the Academic Department of Adolescent Medicine as a Summer Research Scholar. Her expertise, supervision and support have been inspiring and have brought this thesis to fruition. Thank you also to my associate supervisors, Professor David Handelsman and Associate Professor Catherine Hawke, whose time and input have benefitted me greatly and been vital to this project’s success. I wish to acknowledge the National Health and Medical Research Council Project Grant awarded to Professor SteinbecK and I am grateful for personal support from the University of Sydney Faculty of Medicine through the Postgraduate Research Support Scheme and the Dean’s Scholarship Fund Conference Grant. -
Clinical Potential and Putative Risks of Fertility Preservation in Children Utilizing Gonadal Tissue Or Germline Stem Cells
0031-3998/06/5904-0040R PEDIATRIC RESEARCH Vol. 59, No. 4, Pt 2, 2006 Copyright © 2006 International Pediatric Research Foundation, Inc. Printed in U.S.A. Clinical Potential and Putative Risks of Fertility Preservation in Children Utilizing Gonadal Tissue or Germline Stem Cells KIRSI JAHNUKAINEN, JENS EHMCKE, OLLE SO¨ DER, AND STEFAN SCHLATT Department of Cell Biology and Physiology [K.J., J.E., S.S.], Center for Research in Reproductive Physiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261; Department of Pediatrics [K.J], University of Turku, FIN-20520 Turku, Finland; Department of Woman and Child Health [K.J., O.S], Pediatric Endocrinology Unit, Karolinska Institute and University Hospital, SE-171 76 Stockholm, Sweden ABSTRACT: Rapid progress in the development of novel experi- a finite stock of oocytes at birth. Only a few oocytes will be mental strategies to generate fertile gametes from cryo-preserved released during ovulation during reproductive life. The ma- ovarian and testicular tissue motivates oncologists to investigate jority will be lost due to atretic degeneration, and replenish- ways in which gonadal tissue might be preserved. Childhood cancer ment of the oocyte pool from germline stem cells does not patients remain the major pediatric group which can benefit from occur (3–5) (Fig. 1). However, recent reports have challenged these techniques. Other potential candidates include patients with this concept. It has been shown that primordial germ cells in systemic diseases, which require gonadotoxic chemotherapy, patients undergoing gonadectomy, patients with Turner or Kleinefelter’s syn- culture dishes are capable of forming oogonia and follicle-like drome, and boys with cryptorchid testes. -
A Review of the Incidence and Survival of Childhood and Adolescent Cancer and the Effects of Treatment on Future Fertility and Endocrine Development
REVIEW A review of the incidence and survival of childhood and adolescent cancer and the effects of treatment on future fertility and endocrine development M H Botha, MMed (O&G), PhD Unit for Gynaecological Oncology, Department of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Academic Hospital, Tygerberg, Western Cape T F Kruger, MB ChB, MPharmMed (Clin Pharm), MMed (O&G), FCOG (SA), FRCOG (Lond), MD Unit for Reproductive Biology, Department of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Academic Hospital Cancer is not uncommon in children. The reproductive system is an important site for late effects of cancer treatment, and normal pubertal development depends on an undamaged hypothalamic-pituitary-gonadal axis. Fertility compromise can occur due to chemotherapy, radiotherapy to the hypothalamic-pituitary-gonadal axis, or surgery. Cryopreservation techniques of germ cells are improving and may offer hope for fertility preservation. S Afr J OG 2012;18(2):48-53. Cancer is not an uncommon diagnosis in children. The incidence Older children and young adults have historically not been of childhood cancer (generally referring to children up to the age of studied to the same extent as young children with regard to 15) is 110 - 130 per million children per annum.1 It is estimated that cancer incidence. The age range for adolescence for the purpose the cumulative risk of a child being diagnosed with cancer is slightly of scientific reporting has been set at 15 - 19 years.6 More recently higher in boys (1:444) compared with girls (1:594).2 In South Africa the concept of ‘young adult oncology’ has referred to a larger group accurate figures for childhood cancer are not available. -
Preservation of Fertility in Patients with Cancer (Review)
ONCOLOGY REPORTS 41: 2607-2614, 2019 Preservation of fertility in patients with cancer (Review) SOFÍA DEL-POZO-LÉRIDA1, CRISTINA SALVADOR2, FINA MARTÍNEZ-SOLER3, AVELINA TORTOSA3, MANUEL PERUCHO4,5 and PEPITA GIMÉNEZ-BONAFÉ1 1Department of Physiological Sciences, Physiology Unit, Faculty of Medicine and Health Sciences, Bellvitge Campus, Universitat de Barcelona, IDIBELL, L'Hospitalet del Llobregat, 08907 Barcelona; 2Department of Gynecology, Gynecological Endocrinology and Reproduction Unit, Hospital Universitari Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona; 3Department of Basic Nursing, Faculty of Medicine and Health Sciences, Universitat de Barcelona, IDIBELL, L' Hospital et del Llobregat, 08907 Barcelona, Spain; 4Sanford Burnham Prebys Medical Discovery Institute (SBP), La Jolla, CA 92037, USA; 5Program of Predictive and Personalized Medicine of Cancer (PMPPC), of the Research Institute Germans Trias i Pujol (IGTP), Badalona, 08916 Barcelona, Spain Received January 18, 2019; Accepted March 6, 2019 DOI: 10.3892/or.2019.7063 Abstract. Survival rates in oncological patients have been techniques evaluated. Emerging techniques are promising, steadily increasing in recent years due to the greater effec- such as the cryopreservation in orthotopic models of ovarian tiveness of novel oncological treatments, such as radio- and or testicle tissues, artificial ovaries, or in vitro culture prior chemotherapy. However, these treatments impair the reproduc- to the autotransplantation of cryopreserved tissues. However, tive ability of patients, and may cause premature ovarian failure oocyte vitrification for female patients and sperm banking for in females and azoospermia in males. Fertility preservation male patients are considered the first line fertility preserva- in both female and male oncological patients is nowadays tion option at the present time for cancer patients undergoing possible and should be integrated as part of the oncological treatment. -
A Guide for Teaching About Adolescent Sexuality and Reproductive Health
CHRISTIAN FAMILY LIFE EDUCATION: A Guide for Teaching about Adolescent Sexuality and Reproductive Health Written by Shirley Miller for Margaret Sanger Center International © 2001 ~ This guide was written especially for Christians and others who value the importance of talking comfortably and effectively with young people and adults about issues related to healthy sexuality and reproductive health. It provides state of the art information on a variety of topics related to human sexuality, gender, adolescents, growth and development, parenting, domestic violence, STIs, HIV/AIDS, sexual abuse, substance abuse, conflict resolution, goal setting and other important life issues. ~ Margaret Sanger Center International, Copyright 2001 2 CONTENTS Page PREFACE..............................................................................................9 INTRODUCTION: Why Christian Family Life Education? .............10 Important Issues Concerning Adolescents.....................................13 PART ONE: CHRISTIAN FAMILY LIFE EDUCATION About This Guide..................................................................................16 Objectives of the Christian Family Life Education Programme............18 Characteristics of an Effective Christian Family Life Educator ...........20 Providing Support for Parents ..............................................................22 Communicating with Young People about Sex....................................23 Clarifying Values ..................................................................................25 -
Assessment of Skeletal and Sexual Maturity: Theoretical and Practical Aspects
Clin Pediatr Endocrinol 1993; (Suppl 3):15-33 Copyright (C)1993 by The Japanese Society for Pediatric Endocrinology Assessment of Skeletal and Sexual Maturity: Theoretical and Practical Aspects Milo Zachmann Department of Pediatrics, University of Zurich, Kinderspital, Ziirich, Switzerland Abstract. Physical changes of sexual maturation and their clinical relevance are discussed in the first part, and the timetable of development in Swiss girls and boys as established from the Zurich longitudinal study is presented. The second part deals with changes in body size and shape and aspects of skeletal maturation. Prepubertal height is nearly identical in both sexes. During puberty important sex differences become evident and maturation is faster in girls by about 2 years. Puberty bigins at the same stage of skeletal maturation (sesamoid bone) in both sexes, and milestones (e.g. peak height velocity) are reached at the same degree of maturation. For bone age estimation, the Greulich and Pyle method is frequently used, but depending on the situation, that of Tanner et al. may be more useful. For height prediction, the methods of Bayley and Pinneau, Roche et al. and Tanner et al. are most widely used. None of them is always the most accurate one, but depending on the condition and relation between bone and chronologic age, the criteria for selection are discussed. Sex hormones modulate body proportions but have no influence on adult height. Adult height and velocity of maturation are independent multifactorial variables. The sex difference in adult height (12.5cm in Switzerland) is due to several components. Puberty is also characterized by changes in body composition. -
Kristen Cain, MD, FACOG Reproductive Medicine Institute Sanford Health, Fargo, ND
Kristen Cain, MD, FACOG Reproductive Medicine Institute Sanford Health, Fargo, ND s Nothing to Disclose s Reproductive age patients value their fertility Survival of childhood and adult cancers is increasing Treatment and preservation options continue to evolve Failure to discuss fertility issues with young cancer patients can have lasting negative consequences Duffy C et al, Cancer J 2009, 15;27-33. Simon B et al CA Cancer J Clin 2005 55;211-228 Annually more than 130,000 cancer patients are diagnosed in their reproductive years (up to 45) 1 More than 11,000 breast cancer patients are diagnosed under the age of 40 each year 2 21% of gynecologic cancer patients are diagnosed under the age of 45 3 12,000 children (0-19) are diagnosed with cancer each year 4 5-7% invasive breast cancer cases occur in women under the age of 40 (www.seer.cancer.gov.2008 ) 1 American Cancer Society & U.S. Census Bureau 2 Young Survival Coalition 3 Liou WS, Yap S, et al., Fertility and Sterility, 2005. 4 Goodwin T, Ooosterhuis BE, et al., Pediatric Blood Cancer,s 2007. Increasing Cancer Survival Rates Increased Emphasis on Quality of Life + Many Successful Fertility Preservation & Post-treatment Parenthood Options = Patients Need Information About Fertility Risks & Options s Cancer Survivorship Rates are High 77% percent of patients under 45 survive at least five years 1 US Trend: Delayed Childbearing Average age for first child is 25.2 – an all time high 2 More patients have not had children when diagnosed Nearly ¼ of first-time live births occur to women over the age of 30 1 SEER Cancer Statistics Review, 1997-2004. -
Onset of the Release of Spermatozoa (Spermarche) in Chinese Male Youth
AMERICAN JOURNAL OF HUMAN BIOLOGY 12:577–587 (2000) Onset of the Release of Spermatozoa (Spermarche) in Chinese Male Youth CHENG-YE JI1* AND SEIJI OHSAWA2 1Department of Health Care Epidemiology, Beijing Medical University, Beijing, China 2Institute of Human Living Sciences, Otsuma Women’s University, Tokyo, Japan ABSTRACT Data on the prevalence of the first ejaculating emission for 83,902 Chinese boys 9 through 18 years were collected using interviews. Median spermarcheal ages (MSAs) were calculated by using the status quo data and probit analysis. Subjects consisted of 61,812 Han boys from urban and rural areas in 29 provinces, and 22,090 minority boys from 17 minority ethnic groups. Median spermarcheal ages were 14.24 years for urban Han boys and 14.85 years for rural Han boys, and ranged from 13.46 to 16.32 years for the 17 minority ethnic groups. The differences in MSAs between urban and rural Han boys in each province were significant and the correlation ,0.83 ס between MSA of urban and rural boys in each province was high (r P < 0.001). For both urban and rural Han boys, there were significant geo- graphic variations. MSAs of boys living in north China were generally higher than those living in the south, while those living in the west were higher than those living in the east. Variation in MSA may be related to ecological con- ditions in the Chinese Han populations. The different estimates of spermar- cheal ages with two approaches, periodical urine sample analysis vs. inter- view, and their effect on estimating male puberty are discussed. -
Figure 3-7. Exposure-Response Array of Female Reproductive Effects, Maternal Weight and Toxicity, Following Oral Exposure to DIBP
EPA/635/R-14/333 Preliminary Materials www.epa.gov/iris Preliminary Materials for the Integrated Risk Information System (IRIS) Toxicological Review of Diisobutyl Phthalate (DIBP) (CASRN No. 84-69-5) September 2014 NOTICE This document is comprised of preliminary materials. This information is distributed solely for the purpose of pre-dissemination review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. It is being circulated for review of its technical accuracy and science policy implications. National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Washington, DC Preliminary Materials for the IRIS Toxicological Review of Diisobutyl Phthalate DISCLAIMER This document is comprised of preliminary materials for review purposes only. This information is distributed solely for the purpose of pre-dissemination review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This document is a draft for review purposes only and does not constitute Agency policy. ii DRAFT—DO NOT CITE OR QUOTE Preliminary Materials for the IRIS Toxicological Review of Diisobutyl Phthalate CONTENTS PREFACE ..................................................................................................................................................... -
The Teen Years Explained: a Guide to Healthy Adolescent Development
T HE T EEN Y THE TEEN YEARS EARS EXPLAINED EXPLAINED A GUIDE TO THE TEEN YEARS EXPLAINED: HEALTHY A GUIDE TO HEALTHY ADOLESCENT DEVELOPMENT ADOLESCENT : By Clea McNeely, MA, DrPH and Jayne Blanchard ADOLESCENT DEVELOPMENT A GUIDE TO HEALTHY DEVELOPMENT The teen years are a time of opportunity, not turmoil. The Teen Years Explained: A Guide to Healthy Adolescent Development describes the normal physical, cognitive, emotional and social, sexual, identity formation, and spiritual changes that happen during adolescence and how adults can promote healthy development. Understanding these changes—developmentally, what is happening and why—can help both adults and teens enjoy the second decade of life. The Guide is an essential resource for all people who work with young people. © 2009 Center for Adolescent Health at Johns Hopkins Bloomberg School of Public Health All rights reserved. No part of this book may be used or reproduced in any manner whatsoever without written permission except in the case of brief quotations embodied in critical articles and reviews. Printed in the United States of America. Printed and distributed by the Center for Adolescent Health at the Johns Hopkins Bloomberg School of Public Health. Clea McNeely & Jayne Blanchard For additional information about the Guide and to order additional copies, please contact: Center for Adolescent Health Johns Hopkins Bloomberg School of Public Health 615 N. Wolfe St., E-4543 Baltimore, MD 21205 www.jhsph.edu/adolescenthealth 410-614-3953 ISBN 978-0-615-30246-1 Designed by Denise Dalton of Zota Creative Group Clea McNeely, MA, DrPH and Jayne Blanchard THE TEEN YEARS EXPLAINED A GUIDE TO HEALTHY ADOLESCENT DEVELOPMENT Clea McNeely, MA, DrPH and Jayne Blanchard THE TEEN YEARS EXPLAINED A GUIDE TO HEALTHY ADOLESCENT DEVELOPMENT By Clea McNeely, MA, DrPH Jayne Blanchard With a foreword by Nicole Yohalem Karen Pittman iv THE TEEN YEARS EXPLAINED CONTENTS About the Center for Adolescent Health ........................................ -
Physical Growth and Development During Adolescence
10/14/14 Overview • Context Physical Growth and Development • Features of puberty during Adolescence • Evaluation of pubertal development • Adolescent brain development • Resources Annie Hoopes Adolescent Medicine Fellow/LEAH Senior Fellow November 8, 2013 Puberty Basics • Outcomes of puberty • Adult size and appearance • Clear distinction between sexes Features of • Ability to reproduce • Physical changes reflect hormonal changes Puberty • Onset • Girls: Age 7 to 13 years • Boys: 9 to 14 years • Rate • 5 years for girls • 6 years for boys • Differences in timing and rate by gender/ethnicity 1 10/14/14 Definitions Hormones of puberty • Adrenarche – adrenal cortex starts producing • Hypothalamic-pituitary-gonadal axis androgens • Adrenal system • Gonadarche – gonads activated by follicle-stimulating hormone (FSH) and luteinizing hormone (LH) • Pubarche – appearance of pubic hair • Thelarche – appearance of breast tissue • Menarche – age of onset of first menstrual period • Spermarche – age at first ejaculation Hypothalamic-Pituitary-Gonadal (HPG) Axis HPG Axis: After Puberty 2 10/14/14 LH and FSH Testosterone and Estrogen Testosterone Estrogen LH FSH Growth of penis and scrotum **Peripheral conversion Growth of pubic/facial hair Testosterone production Sperm production Low levels: pubertal growth MALES Deepening of voice spurt, accrual of peak bone from Leydig cells from Sertoli cells MALES Increased libido mass Increased muscle mass High levels: closure of Androgen production Acne epiphyses from theca cells Ovarian follicle Thickening -
Understanding the Physical Changes of Puberty Maria R
G1701 Understanding the Physical Changes of Puberty Maria R. de Guzman, Extension Adolescent Specialist 1) Maturation of secondary sex characteristics. Secondary Understanding the Physical Changes of Puberty sex characteristics are those that are related to, but not explains what puberty is and why it occurs, how a directly involved in reproduction. For instance, young body changes and strategies to help youth • As early as age 8, girls experience “breast budding” or through puberty. the emergence of breasts. Hair growth under the arms and pubic areas also begin. Physical changes during the adolescent years are dra- • As early as age 11, boys experience growth in the testicular matic — with teens seemingly growing inches overnight, area, and start facial, underarm and pubic hair growth. their bodies re-shaping and voices changing all at once. This 2) The growth spurt. During puberty, hormones signal the transformation is complex, sometimes confusing, and even body to grow faster. This hastened growth is called “the anxiety provoking. Understanding this process of change, growth spurt.” Some things to note: and knowing what to expect can help prepare youth and their • The growth spurt starts at around age 11 for girls and parents for the transitions ahead. This NebGuide provides read- 13 for boys. Thus, girls become generally taller than ers with basic facts about the changes that teens go through boys during these years, though boys often catch up during puberty. It also provides parents with suggestions on and generally end up taller. how to help their developing adolescent through this period • At the peak of the spurt, boys can increase their height of physical transitions.