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Dr. Wei-Shuo Fang W.-S. Fang Curriculum Vitae Weishuo Fang, Ph.D. Professor of Medicinal Chemistry State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica, Chinese Academy of Medical Sciences 2A Nan Wei Road, Beijing, China Tel: +86(10)63165229 (office) Email: [email protected] Web: http://www.imm.ac.cn/groups/fangws LinkedIn: linkedin.com/in/weishuo-fang-a8654118/ EDUCATION Ph. D. in Medicinal Chemistry (1993-1997), Peking Union Medical College (mentors: Profs. Xiao-tian Liang and Qicheng Fang) B. S. in Pharmaceutical Sciences (1984-1989), College of Pharmaceutical Sciences, Beijing Medical University (currently Peking University Medical Center) PROFESSIONAL EXPERIENCE Professor (2016 – present) Institute of Materia Medica, Chinese Academy of Medical Sciences (IMM/CAMS), China Visiting Scholar (2015 – 2016) Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA (advisor: Prof. Kuo-Hsiung Lee) Chief Executive Officer (2012 – present) Nanjing Tasai Biotech Co. Ltd., China Professor (2006-2015) Department of Natural Products Chemistry, IMM/CAMS, China Associate Professor (2002 – 2006) Department of Natural Products Chemistry, IMM/CAMS, China Visiting Scholar (2001-2002) Department of Biochemistry, University of Illinois at Urbana-Champaign, USA (advisor: Prof. Lowell P. Hager) Associate Professor (1999 - 2001) Department of Natural Products Chemistry, IMM/CAMS, China Postdoctoral Research Associate (1997 – 1999) Department of Chemistry, Florida State University, USA (advisor: Prof. Robert A. Holton) W.-S. Fang Curriculum Vitae Research Assistant (1989-1993) IMM/CAMS RESEARCH ACCOMPLISHMENTS Metabolic Disease Therapy Research (2010 – Present) • Studied farnesoid X receptor (FXR) interacting agents for the therapy of various metabolic diseases, with an emphasis on diabetes and nonalcoholic steatohepatisis (NASH). Two chemotypes of FXR ligands found and patented, currently under preclinical investigations. Translational and Drug Development in Cancer Therapy (2006 – Present) • Studied semi-synthetic taxanes for cancer chemotherapy effective against paclitaxel (Taxol)-resistant tumors. Several patented analogs are at preclinical stage, and antibody drug conjugate (ADC) technology has been applied to tumor-targeting delivery. • Discovered new agents modulating protein-protein interaction(s) between microtubule (MT) and microtubule associated protein (MAP) for selective, low to non- toxic cancer and neurodegenerative disease therapy. Alzheimer’s Disease Therapy Research (2011 – 2018) • Researched beta-secretase (BACE) inhibitors for Alzheimer’s disease therapy. Series of conjugates, based on fragment-based drug discovery (FBDD) strategy and assisted by saturated transfer difference (STD)-NMR technique, was found effective in neuronal cells. Photodynamic Therapy-based Antitumor Drug Development (2010 – 2015) • Involved in the development of porphyrin-based photodynamic therapeutic agents, including “Hua Bu Lin Na” which has been approved by China Food and Drug Administration (CFDA, currently NMPA) for Phase I clinical trial. • Explored the potential of porphyrin and porphyrin-like molecules to facilitate antitumor drug delivery to tumors. HONORS AND AWARDS 4. Second-grade Award for Natural Science Research by Ministry of Education of China, 2014 3. Servier Young Investigator Award in Medicinal Chemistry by Chinese Pharmaceutical Association (sponsor: Servier Laboratories, France), 2004 2. Certificate for Excellent Doctoral Thesis of Universities and Research Institutions of China by Ministry of Education of China, 1999 1. First-grade Award for Science and Technology Progress by Ministry of Health of China, 1996 LECTURES AND SCIENTIFIC MEETING CONTRIBUTIONS Invited lectures, conferences speeches & chairs: 23. Co-chair, the 4nd Workshop on Chemistry and Biology of Microtubules and Microtubule-interacting Agents, Beijing, China, September 18-19, 2018 22. Invited talk, Dr. Tim Mitchison’s lab, Harvard Medical School, October 23, 2017. W.-S. Fang Curriculum Vitae 21. Conference speaker, 2nd International Conference and Exhibition on Marine Drugs and Natural Products. London, UK. June 15 – 17, 2017. 20. Invited lecture, the 2nd meeting of COST Action CM1407 “Challenging organic synthesis inspired by nature - from natural products chemistry to drug discovery”, Madrid, Spain, April 4 – 5, 2016 19. Invited lecture, Beijing Institute of Technology, Beijing, China, 19 Oct 2015 18. Invited lecture, School of Pharmacy, Tsinghua University, Beijing, China, October 29, 2014 17. Chair, the 2nd Workshop on Chemistry and Biology of Microtubules and Microtubule- interacting Agents, Beijing, China, September 10 – 11, 2013 16. Invited lecture, Department of Chemistry, Emory University, Atlanta, GA, USA, April 13, 2013 15. Invited lecture, Department of Biology, Hong Kong Baptist University, Hong Kong SAR, February 4, 2013 14. Invited lecture, College of Pharmacy, Henan University, Henan, China, November 5, 2012 13. Invited speech, Sino-Europe International Conference on Pharmaceuticals 2012, Hubei, China, May 22 – 25, 2012 12. Invited lecture, Department of Molecular and Cell Biology, University of Guelph, Guelph, Canada, February 13, 2012 11. International Conference on Global Challenges for New Drug Discovery Against Tropical Parasitic Diseases, Xcaret, Mexico, December 11-15, 2011 10. Co-Chair, the 1st Workshop on Chemistry and Biology of Microtubules and Microtubule-interacting Agents, Beijing, China, November 8-9, 2011 9. Invited lecture, College of Pharmacy, Yantai University, Shangdong, China, October 23, 2011 8. Invited speech, The 3rd Chinese Taxols (Docetaxel) 360 Industrial Forum, Shanghai, China, August 11-12, 2011 7. Conference speaker, National Symposium for Medicinal Chemistry of China. Wuhan, China, October 10-13, 2009 6. Conference speaker, the 7th National Natural Organic Chemistry Symposium of China. Chengdu, China, September 19-21, 2008 5. Invited lecture, College of Pharmacy, Wuhan University, Wuhan, China, September 22, 2008 4. Invited lecture, Tianjin University of Science and Technology, Tianjin, China, January 16, 2008 3. Co-Chair of Session 11, Annual Congress of Innovative Drug Discovery Science & Technology (IDDST), Xian, China, November 7-13, 2007 2. Conference speaker, Annual Congress of IDDST, Beijing, China, 7-13 Nov 2004 1. the 3rd International Symposium on Natural Drugs, Naples, Italy, October 2 -4, 2003 Abstracts and posters: 35. AACR annual meeting, Atlanta, GA, USA, March 29 – April 3, 2019 34. The 3rd RSC BMCS Medicinal Chemistry Symposium on Macrocycles, Stevenage, UK, October 8 – 9, 2018 33. European Federation of Medicinal Chemsitry – International Symposium on Medicinal W.-S. Fang Curriculum Vitae Chemistry (EFMC-ISMC) 2018, Ljubljana, Slovenia, September 2-6, 2018 32. International Symposium for Chinese Medicinal Chemists (ISCMC), Zhengzhou, China, August 24 2-6, 2018 31. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Philadelphia, PA, USA, October 27 - 30, 2017 30. Chinese Medicinal Chemistry Symposium, Beijing, China, August 27 – 30, 2017 29. AACR annual meeting, New Orleans, LA, USA, April 15 -20, 2016 28. European Pharma Summit, May 5-8, 2015, Berlin, Germany 27. EACR-AACR-SIC Special Conference on Anticancer Drug Action and Drug Resistance, June 20 -23, 2015, Florence, Italy 26. EFMC-ISMC 2014 Lisbon, Portugal, September 7-11, 2014 25. AACR annual meeting, San Diego, CA, USA, April 5 -9, 2014 24. CCS 8th National Organic Chemistry Conference, Chongqing, China, October 17 -20, 2013 23. The 8th National Conference on Chemical Biology, Shanghai, China, September 15 - 18, 2013 22. The 245th ACS National Meeting & Expo, New Orleans, LA, USA, April 7-11, 2013 21. The 33rd National Medicinal Chemistry Symposium, Tucson, AZ, May 20 - 23, 2012 20. The 19th EuroQSAR, Vienna, Austria, August 26-30, 2012 19. AACR special conference on Chemical Systems Biology, Boston, MA, USA, June 27- 30, 2012 18. AAAS Annual Meeting, Vancouver, BC, Canada, February 16-20, 2012 17. Chinese Medicinal Chemistry Symposium, Guangzhou, China, November 17 -20, 2011 16. The 70th Annual Meeting of the Japanese Cancer Association (JCA), Nagoya, Japan, October 3 - 5, 2011 15. The 9th Tetrahedron Symposium, Beijing, China, June 22 – 25, 2010 14. EFMC-ISMC 2010, Brussels, Belgium, September 5-9, 2010 13. The 240th ACS National Meeting & Expo, Washington, DC, USA, August 22 - 26, 2010 12. AACR annual meeting, Philadelphia, PA, USA, April 17 -21, 2010 11. The 2nd International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials, Beijing, China, September 19-23, 2009 10. The 9th AD/PD International Conference, Prague, Czech Republic, March 11 -15, 2009 9. The 5th Modern Drug Discovery and Development Summit (M3D), San Diego, CA, USA, October 14-16, 2009 8. The 7th National Natural Organic Chemistry Symposium, Chengdu, China, September 17 – 19, 2008 7. The 5th National Conference on Chemical Biology, Kunming, China, August 9 -13, 2007 6. The 7th Tetrahedron Symposium, Kyoto, Japan, May 24 – 27, 2006 5. EFMC-ISMC 2010, Istanbul, Turkey, August 29 - September 2, 2006 4. The 25th Chinese Chemistry Society Congress, Changchun, China, July 11 – 15, 2006 3. The 4th National Conference on Chemical Biology, Wuhan, China, October 9 - 12, 2005 2. FEBS Summer School on Science at the Interface of Chemistry, Biology and Medicine, Spetses Island, Greece, July 17 - 29, 2005 1. International Symposium for Chinese Inorganic Chemists (ISCIC)-5
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