ANNUAL REPORT
NATIONAL INSTITUTE OF MENTAL HEALTH AND NEURO SCIENCES Institute of National Importance Bengaluru - 560 029 2015 - 2016 NIMHANS
ANNUAL REPORT | 2015 - 2016 Vasudeva Manja A K. Manjunath NIMHANS Re-dedicated to the service of the nation
An enduring vision, an indomitable spirit and an industrious multi-disciplinary team, these possibly best exemplify the character of the National Institute of Mental Health and Neuro Sciences or NIMHANS.
Spread over an area of nearly 135 acres, NIMHANS is a unique institution that combines mental health and neurosciences under one roof. Such a unique approach has made NIMHANS a premier institute not just in the country but also in the world and its three pillars include service delivery, training and research. Although intended to be a tertiary care referral centre for mental, neurological and neurosurgical disorders, the reputation of its quality care attracts people from all parts of India and from the region. There is always a balanced focus on both curative as well as promotive aspects of mental and neurological health. The therapeutic modalities blend the modern systems of medicine with traditional systems of care and management making it an undisputed leader in the area of mental health and neuro sciences.
NIMHANS is the leading post-graduate training centre in the country particularly in mental health and neuro-sciences,. Occupying a pre-eminent position, it currently runs 53 courses (with many more in the pipeline) and the register includes post-doc fellowships, doctoral studies, superspecialty MCh and DM courses, MPhil, Master’s degree, diplomas and recently undergraduate courses in select disciplines. In addition to the courses run by NIMHANS, thousands of trainees from all over the country come to NIMHANS each year for specialized training in basic sciences as well as in the clinical disciplines.
NIMHANS, over the decades, has emerged as a leader in research in both behavioural sciences and neurosciences. At NIMHANS research occurs in a seamless manner from the bench to the bedside and from the bedside to the community. The institute has made signal contributions in a multitude of areas: from addiction to Alzheimer’s; from mental hospital history to the historical contributions of its forbears; from imaging to intensive care; from brain injury to interventional neuroradiology; from disaster relief to deep brain stimulation; from stroke research to signalling in the brain; from rabies to retroviral infections; from youth mental health to yoga research; from molecular genetics to mindfulness research; from restoration to rehabilitation .....the contributions are vast and varied.
NIMHANS plays a pivotal role in national policy and programming and as a premier institution dedicated for brain, mind and behaviour, historically has always been in the forefront of setting the agenda for mental health in India. The flagship District Mental Health Program of the Government of India emerged out of the Bellary model of care for mentally ill in a primary care set up within the decentralised District health care system. NIMHANS continues to provide the larger impetus to strategise, improvise and bring in innovation in both institutional and community based mental health care services across the country. It has contributed to the National Mental Health Policy and also promotes / supports rights-based mental health care. It actively collaborates and networks with several governmental, quasi governmental and non-governmental agencies / bodies.
The year 2016 was a witness to a historical milestone in the annals of the institute- Honourable President Shri Pranab Mukherjee re-dedicated the institute to the nation as an Institute of National Importance. To commemorate the event, he declared open the Heritage museum and released ‘Landscapes and mindscapes’, a coffee table book; both of which outline the rich and variegated history of NIMHANS. ‘Landscapes and mindscapes’ chronicles growth of NIMHANS from the lunatic asylum in the nineteenth century to the Mysore Government Mental Hospital in 1934, the All India Institute of Mental Health in 1954 and NIMHANS in 1974 to acquiring the status of a Deemed University in 1994 and being bestowed the status of Institute of National Importance through a separate act of Parliament in 2013.
The re-dedication of NIMHANS to the nation has placed a greater responsibility upon the institute, not just to sustain the tremendous strides it has made over the decades, but to raise the bar for clinical care, training, research and policy in the area of mental health and neuro sciences. Vision
To be a world leader in the area of Mental Health and Neurosciences and evolve state-of-the-art approaches to patient care through translational research Mission
Establish the highest standards of evidence-based care for of society and ages including the vulnerable population. psychiatric and neurological disorders and rehabilitation. Evolve and monitor the strategies for disaster management Develop expertise and set standards of care for diseases of and psycho-social rehabilitation in different cultural and public health relevance in the developing world. ethnic groups.
Work with the government and provide consultancy services Promote Mental Health literacy and eliminate the stigma for policy planning and monitoring strategies in the field of attached to the Mental and Neurological illnesses by taking Mental Health and Neurosciences and facilitate execution the measures and the delivery system to the centres of of national health programme. primary health care honouring the human rights and dignity.
Human resource capacity building by training in diverse Integrate allopathic and oriental medicine into health care fields related to Mental Health and Neurosciences. delivery and promote evidence-based research.
Develop and strengthen inter-disciplinary, inter-institutional Integrate physical and metaphysical aspects of Neuroscience and international collaboration with universities and research to promote yoga and its application to positive research institutes across the globe to foster scientific mental health. research, training in advanced technology and exchange of ideas in the areas of Mental Health and Neurosciences. Participate in broad field of Neuroscience and Behavioral Research applicable to human ethics, organ transplantation, Strive to enhance equitable accessibility of primary care in stem cell research, space science, and nuclear science. Mental Health and Neurological Disorders to all sections Organogram
PRESIDENT, NIMHANS
VICE-PRESIDENT, NIMHANS
DIRECTOR
Administration Academics Hospital Services Finance & Internal Accounts Audit Registrar Deans Medical AO Superintendent DFA & CAO AO (A&E)
Basic Sciences Behavioural Neuro Sciences Resident AO Accounts Sciences Medical Officer (Hospital) Officers
Special AAO AAO AAO AAO AAO AAO AAO Casualty AAO AAO Officer (Stores) (Personnel) (Coordination) (Claims) (Hospital) (DP&NR) (OPD) Medical (Accounts) (Projects) Officer
Biophysics Biostatistics Human Genetics Neurochemistry Clinical Neurosciences Epidemiology Neuroanaesthesia Neuro Imaging & Interventional Radiology Neurology Neuropathology Neuromicrobiology Neurophysiology Neurovirology Psychopharmacology Neurosurgery Speech Pathology & Audiology Transfusion Medicine & Haematology
Child & Adolescent Psychiatry Clinical Psychology Health Education Neurological Rehabilitation Nursing Psychiatry Psychiatric Social Work
Psychiatric Rehabilitation Services
Special Centres (Academic & Research) • Centre for Addiction Medicine • Neurobiology Research Centre • NIMHANS Centre for Well Being • Free Legal Aid Clinic • Centre for Public Health • NIMHANS Integrated Centre for Yoga • Sakalawara Community Mental Health Centre
Contents
From the Director’s Desk...... 9
Awards, Honours and Key Assignments...... 31
Visitors to Nimhans...... 44
Patient Care Activities...... 51
Human Resource Development...... 75
Conferences/Symposia/Workshops I. Scientific Programs Organised at NIMHANS...... 86 A. International...... 86 B. National...... 86
II. Scientific Programs Organised Outside NIMHANS...... 95 A. International...... 95 B. National...... 96
III. Specific Training Underwent by Faculty/Staff...... 101
Central Facilities...... 104
Research Activities Biophysics...... 120 Biostatistics...... 128 Child and Adolescent Psychiatry...... 128 Clinical Neurosciences...... 131 Clinical Psychology...... 135 Epidemiology...... 147 Human Genetics...... 149 Mental Health Education...... 152 Neuroanaesthesia...... 153 Neurochemistry...... 155 Neuro Imaging and Interventional Radiology...... 161 Neurological Rehabilitation...... 163 Neurology...... 164 Neuromicrobiology...... 169 Neuropathology...... 171 Neurophysiology...... 175 Neurosurgery...... 197 Neurovirology...... 200 Nursing...... 203 Psychiatry...... 205 Psychiatric Rehabilitation...... 214 Psychiatric Social Work...... 216 Psychopharmacology...... 221 Speech Pathology and Audiology...... 222 Transfusion Medicine & Haematology...... 222 Ayurveda ...... 223
Publications A. International Journals...... 227 B. National Journals...... 248 C. Book Chapters/Conference Proceedings...... 257 D. Monographs/Manuals/Reports...... 262 E. Newsletters/Souvenirs...... 264 F. Articles for General Public/IEC Materials...... 264 G. Books Published...... 266
Contributions to Scientific Deliberations A. Presentations in International Conferences...... 267 B. Presentations in National Conferences...... 280 C. Resource Persons...... 308 D. Radio/TV/Phone-in Programmes...... 314
Public Lectures...... 315
Statutory Bodies...... 320
Faculty and Staff...... 331
Finance and Accounts...... 341
Homage ...... 369 Dr. K. S. Meena From the Director’s Desk
It gives me distinct pleasure to present the Annual Report of National Institute of Mental Health & Neuro Sciences (NIMHANS) along with the audited statement of accounts for the period from 1st April 2015 to 31st March 2016.
I would like to take this opportunity to congratulate and also place on record our immense thanks to Prof. P. Satishchandra, who as the Director/Vice-Chancellor demonstrated steadfast leadership and brought accolades to the Institution. The five plus years of his service (as Director/Vice-Chancellor from 29th June 2010 to 28th June 2015 and In-Charge Director from 22nd August 2015 to 11th January 2016) will be remembered for the several patient friendly initiatives, proactive measures and key milestones achieved. The dynamism and team-work he brought into the system helped us grow and will enable to scale new heights. I place on record our heartfelt compliments to Prof. N. Pradhan (29th June 2015 to 31st July 2015) and Prof. G. S. Umamaheswara Rao (1st to 21st August 2015) for their valuable services as In-Charge Directors.
NIMHANS ranks among the nation’s leading institutes for high standards of clinical care, quality training and research in mental health and neurosciences, and is fast emerging as a destination centre for specialized services. It is acclaimed globally for cutting edge research in frontier areas. In the past year, NIMHANS opened the doors to new facilities and advanced technology for delivering better patient care and promoting high-impact research. We have also forged valuable partnerships with prominent institutions and organisations in India and globally to promote collaborative research and academic programmes for mutual benefit. All of these progressive and quality-focused initiatives will help to ensure that NIMHANS maintains its outstanding reputation in the future as well, and it continues to develop unfettered.
It is with great pride that I share this overview of significant progress and achievements during the year. NIMHANS has made major strides towards realizing its vision and mission. I would like to take this opportunity to thank all the faculty, staff and students of the Institute for their inspirational commitment and dedication.
Prof. B. N. Gangadhar Director Annual Report 2015-2016
1. Patient Care Services 2. Human Resources Development
Clinical services offered by NIMHANS have consistently 2.1 Academic programmes demonstrated quality outcomes that positively impact the patients, their families and the entire community. By adopting A vibrant culture of initiative and innovation, dedicated faculty holistic and multi-disciplinary approach, the Institute and interdisciplinary scholarship set the training ground for continued to provide evidence-driven models of clinical care the next generation of professionals in the field of mental for individuals, across all age groups, affected by various neuro- health and neurosciences at the Institute. psychiatric disorders. During the review period, 19 professionals completed Post- Comprehensive patient care services, benchmarked for high Doctoral Fellowship (one each in Child & Adolescent Psychiatry, quality, primarily reach out to the less privileged sections of Acute Care and Emergency Psychiatry, Consultation Liaison the society. During the year 2015-16, about 5.2 lakh patients Psychiatry, Geriatric Psychiatry, Obsessive Compulsive Disorder & from various parts of the country and across the globe received Related Disorders, Neuroinfections, Neurological Rehabilitation, specialised medical care for psychiatric and neurological Transfusion Medicine, Community Mental Health, Clinical problems. About 75 per cent of the patients received the Neuro Sciences & Therapeutics; two each in Addiction Medicine, treatment at no cost or at highly subsidized costs. Neuroanaesthesia, and Neuropathology; and three in Neurocritical Care). A total of 22 completed PhD (one each in Neurosurgery, Particulars 2014-15 2015-16 Neurophysiology, Neurology, Neuromicrobiology, Human Screening 1,13,135 1,17,478 Genetics, Speech Pathology & Audiology and Nursing; two each Registrations 54,710 58,219 in Neurophysiology and Psychiatry; four in Clinical Psychology; Extension Services* 25,397 23,662 and seven in Psychiatric Social Work); 202 candidates were Follow-ups 2,42,110 2,55,479 declared qualified to receive degrees in various specialties: DM Emergency Care 44,543 49,742 (Neurology), DM Neuroimaging & Interventional Radiology, Admissions 17,227 16,325 DM (Child & Adolescent Psychiatry), DM (Neuroanaesthesia), Discharges 14,801 14,857 MD (Psychiatry), M.Ch (Neurosurgery), Diploma (Psychiatry), Deaths 689 921 MPhil, MSc, BSc Degrees, Post-Basic Diploma and Diploma in *at seven places: Gunjur, Gowribidanur, Maddur, Kanakapura, Madhugiri, Sakalawara, and Turuvekere Nursing. A total of 5110 students from various other institutes - from India and abroad - visited NIMHANS and underwent The Department of Psychiatry runs various specialty clinics training during the year. and services including Centre for Addiction Medicine Sl. Total No. of (CAM), Family Psychiatry Centre, Geriatric Clinic & Course No. Students Services, Obsessive Compulsive Disorder (OCD) Clinic, 1 Postgraduate degree/diploma and undergraduate Electro Convulsive Therapy (ECT) Services, Transcranial a) Joined the Institute during the year 2015-16 233 Magnetic Stimulation Laboratory, Transcranial Direct Current b) Completed and declared qualified during the year 202 2015-16 Stimulation (tDCS), Schizophrenia Clinic & Metabolic 2 PhD Clinic, Genetic Counselling and Testing (GCAT) Clinic, a) Joined the Institute during the year 2015-16 33 b) Completed and declared qualified during the year 22 Emergency Psychiatry and Acute Care (EPAC), Community 2015-16 Psychiatry Services, Perinatal Psychiatry Services, Molecular 3 Post-Doctoral Fellows 19 Genetics Laboratory, Consultation Liaison Services, 4 Short-term training (from outside institutions) 5110 Telemedicine Services, and Free Legal Aid Services to facilitate comprehensive care. 2.2 Capacity building and strengthening human resource development The Department of Neurology in association with other departments of the institute also extends specialty services NIMHANS promotes innovative, academically-led working through Neuromuscular, Epilepsy, Movement Disorder, environment to advance knowledge, leverage expertise and Dementia and Geriatric Clinics. enhance health care delivery. Facilitating capacity building and
10 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 strengthening human resource development in different health Research activities at the Institute take place in a wide care delivery systems form the prime mandates of NIMHANS. range of departments, programmes, and centres, through The institute is actively involved in imparting advanced technical active collaborations with various prominent regional, knowledge to medical, para-medical and nursing professionals national and international agencies. The thrust areas of to promote skills and evolve employable manpower to meet the research continue to be: a) unraveling the molecular and needs of the nation. Training is also extended to caregivers, police sub-cellular mechanisms for disease process, b) linking personnel, media persons, administrative medical officers among clinical status with structural, biochemical, immunological others. In addition to the short-term training programmes, and serological abnormalities searching for biomarkers, c) faculty, staff and students of NIMHANS routinely conduct exploring genetic basis for disease causation, d) developing and participate in various seminars, workshops, conferences and prognostic and clinical predictors and diagnostic inventory/ other academic endeavours both within and outside the Institute. checklists.
During the year 2015-16, NIMHANS, hosted several During the period 2015-16, a total of 840 scientific articles/ international and national scientific deliberations. The faculty communications were published (430 articles in International of the Institute organised 318 educational/ resourceful events Journals, 204 in National Journals, and 206 other publications (workshops / symposia / conferences: 173 at NIMHANS and including monographs, manuals, chapters in books, articles in 145 outside the Institute). A total of 21 faculty and staff members newspapers, etc.). underwent specific training to expand their knowledge and skills. RESEARCH PUBLICATIONS The second TS Srinivasan NIMHANS Knowledge Conclave 2016 Internaonl.Journals Naonal Journals Other Publicaons Total 900 840 900 with contemporary theme “Cognition & Dementia” was jointly 767 800 742 800 723 organised by NIMHANS and NEUROKRISH, Neurosciences 700 626 700 600 430 600 India Group on 12-13 February 2016. Lead by Prof. Ron Petersen 340 357 404 of the Mayo Clinic, Rochester, who has developed the concept of 500 269 500 400 400 Mild Cognitive Impairment, the conclave featured international 300 194 216 204 300 183 and Indian faculty of eminence in this field. 200 191 200
100 174 208 194 206 100 128 0 0 Dr. Ramachandra N Moorthy Foundation for Mental Health and 2011-12 2012-13 2013-14 2014-15 2015-16 Neurological Sciences at NIMHANS funded 33 events to promote training and academic activities in the field of mental health. RESEARCH PROJECTS
Total amount (INR in crores) th 100 327 350 Neurotrauma 2015, the 24 Annual National Conference of Amount Per annum (INR in crores) 322 90 289 Neurotrauma Society of India, was organised at NIMHANS. Total no. of projects 300 80
The event was attended by 340 delegates and 130 nurses. The 70 250 199 60 conference highlighted the recent advances in management of 200 50 94 head injury and catered to a wide audience extending beyond 150 40 115 78 69 neurosurgery. A parallel event was conducted exclusively for 30 60 100 48 20 neuro-nurses. The details of the other scientific deliberations 34 26 29 50 21 10 16 and conferences organised by the Institute are provided 0 0 separately in the respective section. 11-1212-13 13-1414-15 15-16
Magnetoencephalography (MEG) Research Centre, the 3. Research first of its kind in the country, was formally inaugurated by Shri. Pranab Mukherjee, Hon’ble President of India, on 22 NIMHANS is synonymous with cutting-edge research December 2015. The centre has been started with a mission that is both interdisciplinary and translational, facilitating of providing state-of-the-art support to research in the field of practical applications for human and societal benefit. neurosciences and in diagnosis of clinical conditions.
National Institute of Mental Health and Neuro Sciences 11 Annual Report 2015-2016
4. New Initiatives – New Facilities 3-3 protein in human CSF samples with a turnaround time of 15 days. 4.1 Enhanced Patient Care Services 8. Multi-Sensory Unit, which is a part of the Occupational 1. A new Neuro-Ophthalmic Unit has been established to Therapy Section, has been made functional, catering to offer dedicated services for evaluation of patients with the needs of patients with developmental disorders. neuro-ophthalmic conditions. The unit has state-of-the- art facilities for refractive errors assessment, perimetry, 9. Structured Social Skills Training Sessions for day slit-lamp examination and fundal photography. boarders and in-patient referrals have been started by Psychiatric Rehabilitation Services from the month of 2. The EEG/ENMG Unit has been expanded with six September 2015. These are delivered either in the group new laboratories which house latest EEG and ENMG format or through individual sessions depending on the facilities and an elaborate reporting station. suitability for the client. Assessment was done using the Social Skills Assessment Screening Scale developed at 3. The Department of Neuroanaesthesiology has expanded Psychiatric Rehabilitation Services. its intensive care facilities with the procurement of Transoesophageal Echo Probes and Intraoperative- 10. Enhancing OPD Services’ programme has been initiated evoked Potential Monitoring equipment. Portable by NIMHANS, based on the observations and advices ultrasound is also made available in all the ICUs and is of the Chairman, NIMHANS Hospital Management being regularly used by the physicians to diagnose various Committee. Under the programme, various initiatives conditions in the intensive care. such as segregation of OPD registration from clinical work, mandatory appointments for all patients, 4. An advanced slide digitizer has now been installed in the distribution of patient flow (into three time slots), Department of Neuropathology. The process of digitizing remodelling screening block services, improving the public the histopathology slides has also been initiated. Digitized canteen facility, etc. have been planned. The core team images not only help in analyses, but also archiving all cases. is headed by the Medical Superintendent, NIMHANS. Prof. Akhilesh KB, Professor of Management Sciences, 5. New specimens depicting various pathological lesions have Indian Institute of Science (IISc), Bengaluru; Prof. Amit been included in the Neuropathology Brain Museum. Prakash and Prof. Srikanth, from International Institute Brain fiber dissection technique has been incorporated of Information Technology, Bengaluru (IIIT-B) are the with tractography correlation in collaboration with Dept. external consultants for the programme. of Neurosurgery. Mulligan and Ashton’s brain slice staining techniques have been employed to differentiate grey from 11. Neurosurgery Skills Lab, a unique facility, has been started white matter. The Human Brain Bank has completed for expanding education spectrum and enhancing skills. sorting of fresh brain samples and digitalization of the bank The lab is equipped with state-of-the-art equipment has been started for the management of sample inventory. including operating microscopes, endoscope sets, drills etc.
6. Neuromuscular Lab & Neuro-oncology Lab, Neurobiology Research Centre, has introduced two new 4.2 Outreach / Public Education and Extension tests as part of the Self-Sustaining Diagnostic Facility, Activities / Awareness Programmes which include Myositis Panel/Profile for characterizing inflammatory myopathies and Molecular Tests for Centre for Public Health (CPH): During the year 2015-16, molecular subtyping of medulloblastoma (WNT, SHH, CPH initiated systematic capacity strengthening activities to non-WNT/non-SHH groups). improve service delivery for mental, behavioral and substance use disorders. Training programmes were conducted for all 7. The Department of Neurochemistry has developed new cadres of health personnel in Kolar district. During the year, 54 test (immunoblot assay method) for quantification of 14- specialists, 97 medical officers, 50 private practitioners and 878
12 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
ASHA workers were trained in recognizing and management The visitor footfall has been increasing every year owing to of common mental health problems including epilepsy. The the wide dissemination of information about the facility in the training programme was a collaborative effort of the local print, electronic and social media. branches of the Indian Medical Association and the Kolar Chapter of the Karnataka Government Medical Officer’s NIMHANS Integrated Centre for Yoga (NICY): The centre Association. facilitates services, training and research activities related to yoga in mental health and neurosciences. NICY has a Yuva Spandana Kendras (YSKs) were established in 20 districts multidisciplinary working group of faculty members, from 13 of Karnataka for facilitating youth health promotion and departments, interested in yoga and allied activities. empowerment, under the Yuva Spandana programme. This programme has now been expanded to all districts in the state. During 2015-16 a total of 14238 patients and caregivers At present, about 90 Yuva Parivarthakas are actively involved availed yoga services. Separate sessions were held for patients in providing various services to the youth including organizing with different neuro-psychiatric disorders and caregivers by sensitization programmes (reaching about 2.32 lakh youths in expert yoga therapists using validated yoga modules. state). A set of 10 training modules has been developed, as part of the programme. Training programmes: Apart from the regular services, NICY conducted four Yoga Appreciation Courses, each spanning NIMHANS Centre for Well-Being (NCWB): The urban one-month, for the staff and students of NIMHANS from community centre, which aims at working on preventive and April 2015-March 2016. More than 60 persons participated promotive aspects of mental health centre, conducted about 75 in the courses and received appropriate training in yoga. interactive workshops and health education programmes for The Centre has also developed a video CD containing yoga various groups – students, parents, teachers, elderly, general public, modules for patients with schizophrenia and depressive mental health professionals and medical professionals, during disorders. The videos are being used in the sessions conducted 2015-16. The centre has trained more than 2000 people in the at the centre as well as at homes of the patients. Similar video community on different aspects of mental health, which includes tools are being developed for other disorders. The centre has both in-house and outreach services in the last one year. Various also received requests for training/ internship from different outreach programmes on mental health education were organised countries. for Anganwadi children, adolescent girls and teachers of a few government schools, and young mothers in Primary Health Centre. In 2015-16, two psychologists from France and Germany were trained in Yoga for mental disorders. Four editions of The centre brought out five IEC leaflets on mental health the quarterly newsletter, Samatvam, were brought out by related topics: (a) Protecting children from sexual abuse (b) NICY. The newsletters received wide appreciation from the IPV – First-hand Information (c) Nurse: Nurses Recovery target audience. The staff and faculty of the centre delivered from Stress & Exhaustion (d) Self Injurious Behaviour (e) more than 10 invited lectures at various conferences/ Psychological Trauma: The Invisible Scars. Three issues of seminars. e-Samatvam, an e-newsletter ( June 2015 edition) ‘The Loudspeaker – Amplifying the Voice of Mental Health’, complementing the print edition was released in collaboration a mental health magazine for general public were published with the White Swan Foundation on their online portal. with support from Dr. Ramachandra N Moorthy Foundation Various information brochures on yoga and mental health for Mental Health & Neurological Sciences. were also brought out. A number of distinguished guests from various parts of India and abroad visited the centre during the Neuropathology Brain Museum: The Neuropathology Brain review period. Museum (Human Brain Museum), which houses normal and pathological brains, serves as a core resource for students and 4.3 Academic & Capacity Building visitors interested in neurosciences. It exists to support medical/ allied-health trainees and professionals in their study of human 1. A new super specialty degree, DM in Addiction brain anatomy and pathology. The museum received 5183 visitors Psychiatry (three-year duration) has been introduced during the year 2015-16, in contrast to 4184 the previous year. (from July 2015).
National Institute of Mental Health and Neuro Sciences 13 Annual Report 2015-2016
2. After successfully conducting the PDF programme in This programme will be held once in three months. Neuropathology for more than a decade, the Department of Neuropathology has initiated the course of DM in 8. The Emergency Psychiatry and Acute Care (EPAC) Neuropathology — for the first time in the country — to services unit with the support of the Department of enhance capacity building and manpower development. Neuroanesthesia has started annual training programme The course has started from July 2015 and the first DM in Basic Life Support (BLS) for residents and faculty student has enrolled for the programme. (about 180 members) from the Department of Psychiatry.
3. Approval has been granted to start three new Post- 4.4 Building & Infrastructure Doctoral Fellowship (PDF) programmes in the areas of Women’s Mental Health, Forensic Psychiatry and Brain 1. Eight consultation rooms have been added to the Adult Stimulation from the next academic year. Psychiatry OPD (G.15 Ground Floor). The additional facilities were inaugurated on 29 April 2015. 4. The Department of Psychopharmacology conducted about 75 separate academic activities under the aegis 2. Disaster Recovery Centre (located behind the Library of eJCIndia (e-Journal Club of India), a national and Information Centre at the Administrative Block) platform that conducts regular teaching activities and was inaugurated by Dr. Arun Kumar Panda, Additional provides education and guidance on aspects of research Secretary, Ministry of Health & Family Welfare, methodology to postgraduate students and academic Government of India on 15 May 2015. The centre has psychiatrists in India. The eJCIndia platform is an been set up to protect critical data of patients in the initiative of the Department that is supported by the event of a natural disaster or other emergency that causes Indian Psychiatric Society. downtime of the Data Centre. The centre runs on 10 Gbps bandwidth connectivity to critical departments like 5. The Department of Epidemiology has initiated Open Emergency, OPD, Neurocentre and other laboratories Academic Programmes for public health post graduates. which are patient data intensive. The centre is equipped During the year, two programmes— ‘Overview of with Modular Safe, a state-of-the-art technology of IP56 mental, neurological and substance use disorders’ and and F90 standard, to ensure protection from fire, water ‘Application of census data in epidemiology’— were and dust in a cost effective manner. conducted as part of the initiative. New training workshops in advanced epidemiology and prevention and management of MNSUDs for industrial medical officers were also conducted.
6. The Virtual Knowledge Network (VKN), the online capacity building facility, has now been extended to Rehabilitation Psychiatry and Perinatal Psychiatry, in addition to Addiction Psychiatry. The academic programmes based on these areas are beamed across the country through VKN, and are made available on the web portal too. Dr. Arun Kumar Panda, Additional Secretary, Ministry of Health & Family Welfare, Government of India, inaugurating the Disaster Recovery Centre 7. The Department of Mental Health Education has initiated a training programme namely ‘First Aid for 3. A spacious Seminar Hall, with a seating capacity of 200, Mental Health Problems’, targeting college students, on the fourth floor of Dr. MV Govindaswamy Centre was teachers and lay counselors. It is designed to equip inaugurated on 5 June 2015. The air-conditioned hall, built people with a set of skills to assess people at risk for on modern standards is suitable for holding both national developing mental illness and provide initial assistance. and international seminars and other educational events.
14 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
4. Foundation stone was laid for the construction of Dr. Ramachandra, Additional Professor & Head, Department NIMHANS Sub-Specialty Block—to be named after of Nursing, received the prestigious National Florence Prof. RM Varma, Founder-Director of NIMHANS— Nightingale Award from the Hon’ble President of India Shri. within the Neuro Centre premises on 24 September Pranab Mukherjee on the occasion of International Nurses 2015. The seven-floor centre, with a built-up area of Day, Rashtrapati Bhavan, New Delhi. The Award carries Rs. 9600 sq. meters, will have 125 beds, 25 ICU beds, two 50, 000/- cash, a certificate, a citation certificate and a medal. operation theatres and advanced laboratory facilities. Dr. G. Venkatasubramanian, Professor, Department of 5. Foundation stone for the Cyclotron project was laid Psychiatry, received the prestigious ‘Swarna Jayanthi Fellowship on 22 October 2015 in the state-of-the-art MR-PET Award’ for the year 2014-15 by the Department of Science and Scan Centre. The advanced centre, with the addition Technology, New Delhi. of Cyclotron for the production of ultra-short-lived radiopharmaceuticals, would enhance diagnoses of Dr. K. Thennarasu, Professor, Department of Biostatistics, various complex neurological and psychiatric disorders received Fellow of Society for Medical Statistics (FSMS) in its entirety, giving information about both anatomical award by the Indian Society for Medical Statistics at the 33rd and functional details in real time. Annual Conference of Indian Society for Medical Statistics, KLE University, Belagavi, 14-16 October 2015. 6. NIMHANS Heritage Museum, established to commemorate NIMHANS becoming an Institute of Dr. Shripad A Patil, Professor and Head, Department National Importance, was thrown open to public on 22 of Neuromicrobiology, was honoured with Rajiv Gandhi December 2015. The museum illustrates the history of Education Excellence Award, International Education NIMHANS from its origins in the middle of 19th century Institute, New Delhi, 8 October 2015. as a lunatic asylum through its journey as the Mysore Government mental Hospital, the All India Institute of Dr. P Marimuthu, Additional Professor, Department of Mental Health, till it became NIMHANS. The museum Biostatistics, received first prize for presenting a paper has been established in the building the earlier housed titled ‘Effect of socio-economic differentials on growth and the Children’s Pavilion. development of children from five metropolitan cities of India’, at the Conference on ‘Demographics – Dividend or Disaster’, Jain University, Bangalore, January 29-30, 2016. 5. Recognition for NIMHANS Dr. K John Vijay Sagar, Additional Professor, Department ontributions C of Child And Adolescent Psychiatry, received Best Poster Presentation (co-author) award for the poster titled, ‘Efficacy 5.1 Awards of an Indian indicated program for adolescents at-risk for depression’, at the 1st International Congress of Clinical and Health Psychology with Children and Adolescents, University of Miguel Hernández, Spain, 19-22 November 2015.
Dr. M. Thomas Kishore, Associate Professor, Department of Clinical Psychology, received Best Paper Award, title: ‘Efficacy of DASII Screen in Assessing the Development of Infants in Perinatal Psychiatry Setting’, at the National Conference on Motherhood and Mental Health, NIMHANS Bengaluru, 31 October 2015.
Dr. Sathyaprabha TN, Professor, Department of Dr. Ramachandra Additional Professor & Head, Department of Nursing, Neurophysiology, received Best Poster Presentation Award, title: receiving the prestigious National Florence Nightingale Award from the Effect of carbamazepine monotherapy on electrocardiogram in Hon’ble President of India Shri. Pranab Mukherjee
National Institute of Mental Health and Neuro Sciences 15 Annual Report 2015-2016 patient with complex partial seizure, ECON 2016, Vizag, 13- 1st Conference of the Movement Disorders Society of India 14 February 2016 (MDSICON), Chennai, January 2016.
Dr. Chandra SR, Professor, Department of Neurology, (i) Dr. Rajalakshmi P, PDF, Department of Neuropathology, received Master Teacher Award, for the work done to promote received Best Poster Award (Miscellaneous Category), neurological education in India, SHINE 2016, Chennai, 28 ‘Neuropathological spectrum of drug resistant epilepsy over February 2016 (ii) received Second Best Poster Award, title: a decade – an audit from a tertiary care centre’, NPSICON, ‘Mirror agnosia and mirror image agnosia in patients with Hyderabad, 19-20 December 2015. dementia’, TSS-NIMHANS, Knowledge Conclave 2016, 12-13 February 2016 (iii) Best Poster Award in Movement Dr. Satyakam Baruah, Sr. Resident, Department of Disorders category, title: Catatonia in children following Neurosurgery (i) was chosen as a Prime Minister’s Guest at systemic illness, IANCON 2015, Agra, 1-4 October 2015 (iv) Republic Day parade at New Delhi 2016 as one of the 100 Best Poster Award (co-author), title: The role of T2 perfusion meritorious students for academic excellence in Neurosurgery in therapeutic response assessment of CNS Tuberculosis, (ii) received the Best Paper Award (Neurosurgery) for ‘Can IANCON 2015, Agra, 1-4 October 2015. Cortical Reorganisation Explain the Cause and Relief of Dysesthetic Pain: An fMRI Study’, NSI 2015. Dr. Bindu PS, Additional Professor, Department of Neurology, received the Silver Award for poster presentation, title: Mrs. Deepa Jose, Staff Nurse (Pavilion IV, Psychiatry Wing), ‘Targeted next generation sequencing in children with epileptic received Best Nurse Award, International Nurses Day 2015, encephalopathy: A study from a tertiary care university hospital NIMHANS, Bangalore, 15 May 2015. in South India’, 17th Annual Conference of Infantile Seizure Society, Tokyo, Japan, 25-26 September 2015. Smt. Jayalakshmi Antharaj, Staff Nurse (Neuro Surgical Intensive Care Unit, Neuro Centre) received Best Nurse Award, Mr. Ravi G S, PhD Scholar, Department of Biostatistics, International Nurses Day 2015, NIMHANS, Bangalore, 15 May received Best Paper Award, ‘Censored Quantile Regression 2015. based gene signature for prognosis of Glioblastoma’, 33rd Annual Conference of Indian Society for Medical Statistics, Smt. Tejeswini, Staff Nurse (Casualty Block) received Best KLE University, Belagavi, 14-16 October, 2015. Nurse Award, International Nurses Day 2015, NIMHANS, Bangalore, 15 May 2015. Dr. Shilpa Rao, Sr. Resident, Department of Neuropathology, received Best Poster Award (2nd Prize, Infections Category), 5.2 Oration by NIMHANS Faculty ‘Neuropathological correlation of neuroimaging features in human rabies encephalitis’, NPSICON, Hyderabad, 19-20 Dr. Satish Chandra P, Senior Professor, Ex Director/Vice- December 2015. Chancellor, NIMHANS (i) Padmshree Thruvengangadam Oration on Translational research in Epilepsy: Indian Dr. Chetan S Nayak, Sr. Resident, Department of Clinical Perspective, Savitha Medical College, Chennai, 10 October Neurosciences, received International League Against Epilepsy 2015 (ii) delivered 2nd SDIN Oration on Translational research (ILAE) ‘Young Investigator’s Award’ & ‘Best Poster’ Award in Epilepsy, Jaipur, 8 February 2016. presentation of a poster titled ‘Effect of valproate on the sleep microstructure of patients with juvenile myoclonic epilepsy’ at Prof. Shankar SK, Emeritus Professor, 9th Dr. RM Varma Oration, the 31st International Epilepsy Congress (IEC) 2015, Istanbul, Lessons in the Pathogenesis of CNS Tuberculosis and Drug Turkey. Resistance, Neurological Society, Bengaluru, 26 March 2016.
Dr. Ragasudha Botta, PhD Fellow, Department of Clinical Dr. Pratima Murthy, Professor, Department of Psychiatry, Dr. Neurosciences, received Best Poster Award, title: ‘Study of Mangalvedhe Memorial Oration, ‘Alcohol Dependence - The Sleep Architecture, Cognition and Neurochemical Correlates how and why?’, IMA Hubli, 4 April 2015 (v) Maurice Bloch in Parkinson’s Disease and other Atypical Parkinsonism’, at the Lecture, ‘Addiction treatment in India-bridging chasms, not
16 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 just gaps,’ University of Glasgow, November 2015. Chief Guest. Shri. M. Lakshminarayana, Principal Secretary, Department of Medical Education, Government of Karnataka Dr. Manoj Kumar Sharma, Additional Professor, Department was the Guest of Honour. of Clinical Psychology, Psycho Oration Award, National Annual Conference of Indian Association of Clinical Dr. K. Lalitha, Professor & Head, Dept. of Nursing, who Psychologists, RIMS, Imphal, 27 March 1.6 received the prestigious National Florence Nightingale Award for the year 2014-15 from the Hon’ble President of India at Dr. Naveen Kumar C, Associate Professor, Department the Rashtrapati Bhavan, New Delhi for her contribution to of Psychiatry, Tilak Venkoba Rao Oration Award-2015, the field of nursing as an educator and administrator, was ANCIPS-2016, Bhopal, 21-24 January 2016. felicitated on the occasion.
Awards for Best Staff Nurse and Best Wards (psychiatric 6. Activities and Events at Nimhans and neuro wings) were also presented on the occasion. Staff Nurses Mrs. Deepa Jose (Pavilion IV, Psychiatry Wing), Smt. Dr. B.R. Ambedkar Jayanti and Buddha Jayanti Celebrations Jayalakshmi Antharaj (Neuro Surgical Intensive Care Unit, Neuro Centre) and Smt. Tejeswini (Casualty Block) bagged Bharat Ratna Dr. B.R. Ambedkar’s 124th Birth Anniversary and the Best Nurses Award for 2013-14. The Best Ward Awards Buddha Jayanti were celebrated on 6 May 2015 at NIMHANS. were presented to Pavilion III (Psychiatry wing) and Female Dr. L. Hanumanthaiah, Chairman, Kannada Development Neuro Surgical Ward (Neuro Centre). Authority, and noted litterateur was the Chief Guest. Venerable Manorakhita Bhanteji, Chief Abbot, Jetavana Buddha Vihar, A poster exhibition based on the Nurses Day Theme was also Kollegal, Chamarajanagar was the Guest of Honour. organized by students from the College of Nursing.
Prof. P. Satish Chandra, Director/Vice-Chancellor, NIMHANS, presided over the function. Folk artistes from Drama & Arts Division of Kendriya Sadan, Bangalore presented a cultural programme on the occasion.
International Nurses Day 2015
International Day of Yoga
The first International Day of Yoga was celebrated on 21 June 2015. Refresher course, yoga competition and various other Bharat Ratna Dr. B.R. Ambedkar’s 124th Birth Anniversary and Buddha Jayanti celebrations important programmes were held as part of the weeklong celebrations. The mass yoga sessions witnessed more than 500 International Nurses Day 2015 participants. ‘Yoga Sandesha - An Exhibition on Yoga’ was held at the Visvesvaraya Industrial and Technological Museum The International Nurses Day was celebrated on 15 May 2015 and NIMHANS simultaneously. The celebrations culminated under the theme “Nurses: A Force for Change: Care Effective, on 29 June 2015, with a public function graced by Dr. Dilip Cost Effective”. Jeste, ex-President, American Psychiatric Association, as the chief guest. Information brochures on yoga and mental health Dr. Arun Kumar Panda, Additional Secretary, Ministry of and the print version of ‘Samatvam’ newsletter, brought out by Health & Family Welfare, Government of India was the Integrated Centre for Yoga, were released on the occasion.
National Institute of Mental Health and Neuro Sciences 17 Annual Report 2015-2016
World Mental Health Day
World Mental Health Day celebration, under the theme ‘Dignity in Mental Health’, was held on 12 October 2015. The event was organised by NIMHANS in collaboration with Dharwad Institute of Mental Health and Neuro Sciences (DIMHANS) and Indian Psychiatric Society, Karnataka Chapter.
Shri. J. Arun Chakravarthy, Inspector General of Police, Central Range – Karnataka was the Chief Guest. Prof. Raveesh B.N., Director, DIMHANS, Dharwad and President, Indian Psychiatric Society, Karnataka Chapter (IPS-KC) was the Guest of Honour.
DIMHANS had organised a bike rally to spread awareness on mental health, as part of the celebrations. A 30-member team from DIMHANS rode from Dharwad on 11 October 2015 and reached NIMHANS campus in Bengaluru on 12 October 2015. An exhibition in which students presented International Day of Yoga charts showing the importance of care to persons with mental illnesses was also held. Teachers’ Day
Teachers’ Day was celebrated on 5 September 2015. Dr. NS Various information materials on mental health were also Viswanath, Director, Bhavan’s Management Research Center released on the occasion. and Dean, M.P. Birla Institute of Management, Bengaluru was the chief guest of the event.
Dr. Viswanath delivered a special talk on ‘Health Care Professionals—Management Perspectives’. Keeping with the Teachers’ Day tradition, senior faculty members of NIMHANS were honoured for their contributions to the growth of the Institute.
World Mental Health Day 2015
Children’s Day
Children’s Day was celebrated with enthusiasm by the Department of Child and Adolescent Psychiatry on 18 November 2015. Children from Psychiatry Ward actively took part in the various cultural events and showcased their talent.
NIMHANS Gymkhana celebrated Children’s Day on 14 November 2015. Prizes were handed over to the winners Dr. NS Viswanath, Director, Bhavan’s Management Research Center and Dean, M.P. Birla Institute of Management being felicitated at the Teachers’ Day of various competitions held as part of the Children’s Day celebrations programme celebrations on the occasion.
18 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Hegde, Former Judge of Supreme Court of India & Former Lokayukta of Karnataka was the Chief Guest of the event.
Justice Hegde conferred the degrees on the successful candidates and delivered the Graduation Day Address. Meritorious students received awards from the Chief Guest and other dignitaries.
As part of the Lamp Lighting Ceremony celebrations, students and trainees lit the lamp symbolising their dedication to the profession, and took an oath to serve humanity with Children’s Day celebrations at the Department of Child and Adolescent compassion and empathy. Psychiatry
Dr. Anisya Vasanth Memorial Oration Karnataka Rajyotsava
Dr. Anisya Vasanth Memorial Oration was delivered by Dr. Karnataka Rajyotsava was celebrated with great zeal on 30 Carsten Bonnemann, Professor of Neurology & Director, November 2015. Prof. Siddalingaiah, eminent poet and Shri. Neuro Muscular Center, National Institutes of Health (NIH), Janagere Venkataramaiah, noted litterateur and journalist, were USA on 27 November 2015. The topic of the oration was the Chief Guests at the function. ‘Travel in the Lands of Childhood Neuromuscular Disease: Where are We Heading?’ Shadow play, magic and ventriloquism show by renowned magician Shri. Prahlad Acharya held the audience spellbound.
Dr. Carsten Bonnemann, Professor of Neurology & Director, Neuro Muscular Center, National Institutes of Health (NIH), USA delivering the oration Karnataka Rajyotsava celebrations
th Graduation Day and Lamp Lighting Ceremony His Holiness the 14 Dalai Lama’s Visit to NIMHANS (and NIMHANS Integrated Centre for Yoga)
His Holiness the 14th Dalai Lama visited NIMHANS on 7 December 2015 and unveiled the foundation plaque of the Institute’s Integrated Centre for Yoga.
The Nobel Peace Laureate delivered a special address in the packed auditorium at the NIMHANS Convention Centre. The spiritual leader interacted with the audience and answered questions about modern psychology, life after death, serving Hon’ble Justice N. Santosh Hegde addressing the gathering humanity, etc.
The 2nd Graduation Day and 9th Lamp Lighting Ceremony A report on the symposium titled ‘Integrating Scientific and were held on 28 November 2015. Hon’ble Justice N. Santosh Contemplative Approaches to Explore the Mind’ (ISCAEM
National Institute of Mental Health and Neuro Sciences 19 Annual Report 2015-2016
2015) held in association with the Garden of Samadhi Mind Clinic in its outpatient block, Centre for Well Being, Centre Centre, Bengaluru—the previous day (6 December 2015) of for Public Health and Centre for Addiction Medicine, etc. The Dalai Lama’s visit— was presented by Dr. Shivarama He stated that these innovations as well as the NIMHANS Varambally, Additional Professor of Psychiatry. Community Mental Health and Rehabilitation Centre and Neuro-biology Research Centre (NRC) are successful models that could be replicated in other parts of the country. Magneto Encephalography Research Centre and NIMHANS Heritage Museum were also inaugurated by the President on the occasion.
The book titled “Mindscape and Landscape: An Illustrated History of NIMHANS, was released by Shri Vajubhai Vala, Hon’ble Governor of Karnataka. The book traces the history of NIMHANS from its origins in the middle of the 19th century as a lunatic asylum through its journey as the Mysore Government Mental Hospital, the All India Institute of His Holiness the 14th Dalai Lama Mental Health, till it became NIMHANS. NIMHANS Dedication Ceremony The event was also graced by Smt. Pramoda Devi Wadiyar, Hon’ble President of India Shri Pranab Mukherjee dedicated wife of the late scion of Mysore Srikantadatta Narasimharaja NIMHANS, Bengaluru as an Institute of National Importance Wadiyar, and titular head Yaduveer Krishnadatta Chamaraja. to the nation the 22nd of December 2015. Shri Vajubhai Vala, The royal family members visited the NIMHANS Heritage Hon’ble Governor of Karnataka; Shri Siddaramaiah, Hon’ble Museum and other parts of the NIMHANS campus, which Chief Minister of Karnataka; Shri HN Ananth Kumar, capture the rich legacy of the country’s first-ever comprehensive Hon’ble Minister for Chemicals & Fertilizers, Government mental health care institute. of India; Shri Jagat Prakash Nadda, Hon’ble Minister for Health & Family Welfare, Government of India & President, Hindi Week Valedictory NIMHANS; Dr. Sharanprakash R Patil, Hon’ble Minister of State for Medical Education, Government of Karnataka & Valedictory Function of the Hindi Week Celebrations 2015 Vice-President, NIMHANS and Shri BP Sharma, Hon’ble was held on 31 December 2015. Shri. P. Vijay Kumar, Deputy Secretary, Ministry of Health & Family Welfare, Government Director (Implementation), Regional Implementation Office of India were the guests of honour at the historical event. (Ministry of Home Affairs, Govt. of India), Kendriya Sadan, Bengaluru was the Chief Guest.
Valedictory Function of the Hindi Week Celebrations 2015
The Chief Guest, in his address, said Hindi is an important Dedication Ceremony – NIMHANS as an Institute of National Importance medium of communication for exchange of views between the government and the public and wide propagation of the official The President, in his speech, commended various initiatives of language is responsibility of each and every employee of the NIMHANS such as setting up of Brain Bank, Free Legal Aid central government.
20 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Prizes to the winners of various competitions held as part of the predecessors and complimented them for their firm resolve and Hindi Week Celebrations and certificates (of attendance) to guidance in taking the Institute to greater heights. the participants of the Hindi Workshop 2014 were distributed on the occasion. Distinguished service awards were presented to selected staff members of the Institute by the Chief Guest. Diploma courses 20th Convocation and post-doctoral fellowship certificates were also presented to successful candidates on the occasion. The 20th Convocation of NIMHANS was held on 13 February 2016. 162 students were awarded various degrees (post-graduate degrees, doctoral and post-doctoral degrees, diplomas and fellowships) on successful completion of their academic programmes.
Shri Venkaiah Naidu, Hon’ble Minister for Urban Development and Parliamentary Affairs, Government of India graced the occasion as the Chief Guest and delivered the Convocation Address. Shri Jagat Prakash Nadda, Hon’ble Minister for Health & Family Welfare, Government of India 42nd Institute Day celebrations on 15 February 2016 and President, NIMHANS presided over the ceremony in the august presence of the Special Guest Dr. K Radhakrishnan, noted scientist and former Chairman of ISRO. 7. Donations
Prof. BN Gangadhar, Director, NIMHANS delivered the 1. Rs. 1.00 lakh from Mrs. Vanitha Ramaswamy towards welcome address and highlighted the various developments patient care and US$40,000 from Dr. Jayashree and achievements of the Institute during the past year. Sundararajan, Neurologist, The University of Kansas Hospital, towards the visit of two students (from the Dept. of Neurology) to Kansas for short-term training.
2. Dr. Sriram Sonty, Ophthalmologist, USA, donated Rs. 1,00,000 (US$1,700) towards the Brain Museum Research Fund.
3. Shri. Mohammed Moshin, IAS, Bengaluru donated Rs. 25,00,000 for the installation of ventilators.
The 20th Convocation of NIMHANS held on 13 February 2016 4. Mrs. K.S. Srimathi, Bengaluru donated Rs. 5,00,000 for Institute Day Schizophrenia research.
NIMHANS celebrated its 42nd Institute Day on 15 February 5. Justice N. Santosh Hegde, former Lokayukta of 2016. Shri S. Gopalakrishnan, Co-founder of Infosys and Karnataka, donated Rs. 2,50,000 for the benefit of poor Chairman, Axilor Ventures, Bengaluru was the Chief Guest. patients.
Shri S. Gopalakrishnan, in his address, stressed the need 8. Policy Implementation for intensive research in neurosciences and allied areas, and expounded on his collaborative initiatives centred on brain 8.1 Implementation of Right to Information Act and stem cell research and technology. Prof. B.N. Gangadhar, who presided over the function, shared the several initiatives NIMHANS has implemented the Right to Information taken up during the past year, exemplary contributions of his Act 2005 as per the directions of Central Information
National Institute of Mental Health and Neuro Sciences 21 Annual Report 2015-2016
Commission, Government of India, and the Ministry 8.3 Persons with Disabilities Act of Health and Family Welfare, Government of India. Reservation to Persons with Disabilities is provided by A team of Central Public Information Officers headed NIMHANS in line with the provisions of the Persons with by the Registrar of the Institute—who is the Appellate Disabilities (Equal Opportunities, Protection of Rights and Authority—is responsible for providing information to a Full Participation) Act, 1995 in various posts and services of person who seeks information under the RTI Act. The Public the Institute. NIMHANS is also involved in various activities Relations Officer serves as the liaison officer and handles initiated to remedy the exclusion of persons with disabilities correspondence with the authorities concerned. Quarterly by focusing on promoting accessibility, as well as removing returns pertaining to RTI are filed and submitted to Central different types of barriers in the society. Information Commission online as per the prescribed guidelines. During 2015-16, the Institute received about 70 8.4 Official Language olicyP RTI applications, and replies to the queries were sent within the stipulated time. The Official Language Implementation policies and Constitutional provisions (Official Languages Act, 1963 8.2 Government of India Reservation Policy and the Official Languages Rule, 1976) are being strictly implemented at NIMHANS under the guidance of the NIMHANS functions under the Ministry of Health and Department of Official Language, Union Ministry of Health Family Welfare, Government of India and follows the and Family Welfare, Government of India. Advertisements, reservation policy as laid down by the Central Government for notifications, name boards, and sign boards are in Hindi and faculty recruitment and student admission. English. Hindi courses/classes, Hindi typing and stenography training are conducted regularly.
Kayakalp: Clean Hospital Initiative Swachh Bharat Abhiyan (Clean India Mission), the ambitious cleanliness drive, was launched by the Hon’ble Prime Minister of India Shri. Narendra Modi on 2nd October 2014. As part of this vital mission, the Union Ministry of Health and Family Welfare has now come up with a new initiative, ‘Kayakalp’ to encourage public health facilities to work towards standards of excellence in cleanliness and hygiene. Awards are given to those public health facilities that demonstrate high levels of cleanliness, hygiene and infection control, under the initiative. The primary objectives of the award scheme are: to promote cleanliness, hygiene and infection control practices in public health care facilities; to incentivize and recognize such public healthcare facilities that show exemplary performance in adhering to standard protocols of cleanliness and infection control; to inculcate a culture of ongoing assessment and peer review of performance related to hygiene, cleanliness and sanitation; to create and share sustainable practices related to improved cleanliness in public health facilities linked to positive health outcomes. NIMHANS strictly adheres to the guidelines and standard protocols set by the Union Ministry of Health & Family Welfare as part of the initiative. A monthly review of Kayakalp programme at various service zones of the hospital and departments are being regularly conducted. The Medical Superintendent coordinates and evaluates the actions initiated by the various zonal monitoring committees. As a part of Kayakalp program, Green Campus Committee has been set up for better environmental stewardship. Working towards attaining a low carbon, resource efficient and greener campus forms the key objectives of this committee. A significant change in the entire hospital, utility premises, residential campus and hostels has been noticed, garnering appreciation from patients, caregivers and the hospital community. In recognition of the initiatives taken up under the Kayakalp programme, NIMHANS received “Certificate of Commendation” from the Ministry of Health and Family Welfare, Government of India for the year 2015 at the First National Kayakalp Award Ceremony held on 16th March 2016 at New Delhi.
22 National Institute of Mental Health and Neuro Sciences The Road Ahead...
NIMHANS is the Varanasi for Mental Health and Neurosciences education and Human Resource Development. I feel honoured to serve as the Director of this prestigious Institute. NIMHANS has been recognised globally for its quality patient services, comprehensive and integrated clinical care which include a range of interventions from micro-vascular surgical procedures to behaviour therapy to life style modification (Yoga and life skills education) which has resulted in demonstrating models of care in both hospital and community settings; the buzz word being translational research. The infrastructure at NIMHANS is built on a very solid footing. The state-of-art imaging facilities with PET-MRI, Cyclotron and MEG have the potential to let us understand the neural substrates for different neurological disorders and behaviours of clinical significance. These, if employed optimally in clinical care could help make safer and precise ‘surgical procedures’ to obtain relief/cure from the disease / disability. The basic science labs have mastered the advanced techniques to understand the molecular basis of several conditions that have posed challenges to neurologists and psychiatrists; biological marker proteins for a disorder and the gene(s) responsible for it, can now be identified. These results could lead to discovery of novel bio-molecules and drugs against such diseases. Such basic laboratory science technologies will also help to understand molecular and biological mechanisms of the action of traditional treatments like Yoga. NIMHANS recently completed a large national survey using scientific methods and examined nearly 40,000 adults who were 18 years or older. The results revealed that we have over 15 crore population that needs mental health care services. In the light of the new mental health policy and the mental health care bill (that could soon become an Act), amidst the severe shortage of mental health human resources, providing services for this population indeed poses a huge challenge. In this context, NIMHANS wishes to re-dedicate its role at the national level. With advances in tele-communication, NIMHANS wishes to exploit this technology to make a pan-India virtual presence and be able to meet the huge challenge of bridging the gap in human resources by collaborating with health departments both at State and Central Governments. NIMHANS constantly endeavours to keep pace with growing knowledge and demands to set up speciality areas in service, training and research. Therefore, there is the need to quickly complete the establishment of the speciality service wards and the laboratories. Likewise expansion of PG degree courses in such areas including geriatrics is an urgent need. NIMHANS proposes to develop a model plan for comprehensive urban mental health care in the coming years. Blending the modern with traditional approaches to alleviate suffering has been a priority area. Yoga is already an integrated intervention in the services at NIMHANS. Ayurveda is the next one we should attempt. Integrated mental health and neurological care using these as well as modern medicine deserves a systematic and dedicated exploration. This year’s World Mental Health Day had the theme of Psychological First Aid. This is very timely. Our work at NIMHANS amongst disaster survivors is illustrative. There is a definite and immense scope for expanding this to other areas as well. Every family faces a ‘disaster’ event sometime or the other; there is a need to rush mental health services to mitigate the effects of such ‘micro-disaster’. We should strengthen the network of volunteers with more structured ‘training’, who could deliver ‘psychological first aid’. The work of the Centre for Well-Being at NIMHANS which looks beyond the clinical case management merits expansion across the country. The role of paramedical staff deserves to be optimally harnessed. The public ‘mental’ health observatory experiences need to be discussed and deliberated. Given the extraordinary strides NIMHANS has made in the last decade, the future is very bright and at the same time, challenging. With an army of talented faculty, dedicated technical staff and very supportive administrative staff, it is possible to meet these challenges and make the future even brighter not only to NIMHANS but also to patient and student community at large. NIMHANS is positioned at a critical juncture in the time – space and wishes to re-dedicate its role at the national level. While, preparing to meet the challenges related to service, research and training, it comprehends and foresees a role for integrating traditional interventions with modern medical systems and promote mental health for the families and the community as a whole
Prof. B.N. Gangadhar Director Staff who Served NIMHANS (Retired / Superannuated)
Dr. V.L. Sateesh Dr. Ravi Shankar Pandey Medical Superintendent Professor of Psychiatry DOJ: 02.04.1988 DOJ: 30.01.1979 DOR: 30.04.2015 DOR: 30.04.2015 (VRS)
Sri. D. Rajendran Smt. C. Indira Smt. B.S Padma Administrative Officer Nursing Tutor Teacher for MR Children DOJ: 02.04.1979 DOJ: 24.04.1983 DOJ: 21.03.1984 DOR: 30.04.2015 DOR: 30.04.2015 DOR: 30.04.2015
DOJ: Date of Joining; DOR: Date of Retirement Sri. Subramaniam Smt. A. Leema Rosemary Sri. B.G. Balarama Hospital Assistant Nursing Tutor Accounts Officer DOJ: 16.01.1980 DOJ: 29.05.1986 DOJ: 02.03.1979 DOR: 30.04.2015 DOR: 31.05.2015 DOR: 31.05.2015
Smt. D. Susheelamma Smt. N. Vedavathi Manager Sr. Instructor in Leather Goods DOJ: 31.08.1985 DOJ: 10.09.1982 DOR: 31.05.2015 DOR: 31.05.2015
Sri. Abdul Rahman Smt. A. Leelavathi Sri. Ramasingaraiah Manager Steno Gr I UDC DOJ: 26.08.1985 DOJ: 28.04.1983 DOJ: 21.10.1982 DOR: 31.05.2015 DOR: 31.05.2015 DOR: 31.05.2015
Sri. G.N. Siddaraju Sri. Nagaiah UDC (Adhoc) MTS DOJ: 20.02.1989 DOJ: 14.11.1979 DOR: 31.05.2015 DOR: 31.05.2015
Sri. Srinivas Sri. Anjanappa Smt. Bhagyavathi B Office Assistant Hospital Assistant Office Assistant DOJ: 15.03.1979 DOJ: 21.09.1981 DOJ: 19.12.1981 DOR: 31.05.2015 DOR: 31.05.2015 DOR: 31.05.2015 Sri. Chidambara Rao K. Sri. Munishama Rao D.M. Smt. M. Jhansi Rani Hospital Assistant MTS Ward Supervisor DOJ: 16.01.1985 DOJ: 20.02.1989 DOJ: 29.05.1986 DOR: 31.05.2015 DOR: 31.05.2015 DOR: 30.06.2015
Sri. Shivaji Rao Sri. G. Narasimhalu Computer Programmer Chief Technician DOJ: 15.07.1981 DOJ: 08.03.1978 DOR: 30.06.2015 DOR: 30.06.2015
Sri. S. Subramanyam Sri. N. Shankaracharya Sri. Bala Ankaiah Office Assistant MTS Hospital Assistant DOJ: 15.03.1979 DOJ: 27.01.1982 DOJ: 20.09.1982 DOR: 30.06.2015 DOR: 30.06.2015 DOR: 30.06.2015
Sri. R. Raghunath Singh Sri. V. Narayanaswamy Office Assistant Hospital Assistant DOJ: 14.02.1983 DOJ: 21.02.1983 DOR: 30.06.2015 DOR: 30.06.2015
Sri. Munishamappa Dr. N. Pradhan Smt. H. Prema Chinnayya Hospital Assistant Sr. Prof. of Psychopharmacology Ward Supervisor DOJ: 09.01.1985 Director, NIMHANS (29.06.2015 to 31.07.2015) DOJ: 01.09.1979 DOR: 30.06.2015 DOJ: 02.07.1979 DOR: 31.07.2015 DOR: 31.07.2015 Smt. J. Tripti Kalpalatha Sri. J. Theodore Smt. P. Chinnaraju Mavillas Senior Technician Office Assistant Ward Supervisor DOJ: 04.05.1984 DOJ: 21.09.1984 DOJ: 29.05.1986 DOR: 31.07.2015 DOR: 31.07.2015 DOR: 31.07.2015
Smt. J.S. Kalavathy Dr. D.K. Subbakrishna UDC Prof. of Biostatistics DOJ: 07.01.2000 DOJ: 15.01.1979 DOR: 31.08.2015 DOR: 31.08.2015
Sri. Rama Sri. H.K.Veerabhdraiah Sri. S.Bore Gowda Hospital Assistant Office Assistant Office Assistant DOJ: 17.02.1982 DOJ: 10.10.1983 DOJ: 17.10.1984 DOR: 31.08.2015 DOR:31.08.2015 DOR:31.08.2015
Smt. R. Santha Kumari Dr. R. Parthasarathy Hospital Assistant Sr. Prof. of PSW DOJ: 23.07.1993 DOJ: 30.06.1978 DOR: 31.08.2015 DOR: 30.09.2015
Sri. Parameswara Sri. P. Shankarappa Smt. P. Indira Devi Rebecca AAO AAO Ward Supervisor DOJ: 02.04.1980 DOJ: 15.03.1979 DOJ: 17.12.1979 DOR: 30.09.2015 DOR: 30.09.2015 DOR: 30.09.2015 Sri. P.K. Louis Smt. P. Prasanna Kumari Sri. Ramaiah Driver Grade - I LDC Hospital Assistant DOJ: 22.04.1985 DOJ: 22.05.1995 DOJ: 15.05.1982 DOR: 30.09.2015 DOR: 30.09.2015 DOR: 30.09.2015
Sri. K.Bettaswamy Sri. S.Ramachandra Rao Office Assistant Hospital Assistant DOJ: 16.02.1983 DOJ: 16.02.1983 DOR: 30.09.2015 DOR: 30.09.2015
Sri. Malakondaiah Sri. H.N.Anantharaju Smt. Savitha Rao Office Assistant Hospital Assistant Ward Supervisor DOJ: 14.05.1986 DOJ: 23.05.1984 DOJ: 29.05.1986 DOR: 30.09.2015 DOR: 30.09.2015 DOR: 31.10.2015
Dr. Vijay Kumar Kalia Sri. B. Vivekappa Prof. of Biophysics Office Assistant DOJ: 17.03.1986 DOJ: 15.03.1979 DOR: 30.11.2015 DOR: 30.11.2015
Sri. B.L. Sreerangaswamy Sri. P. Malakondaiah Sri. Ananthaiah AAO (Adhoc) Office Assistant Hospital Assistant DOJ: 30.04.1984 DOJ: 01.09.1983 DOJ: 08.06.1987 DOR: 31.12.2015 DOR: 31.12.2015 DOR: 31.12.2015 Smt. Obalamma Sri. Begure Gowda Smt. B.N. Vijayalakshmi Hospital Assistant Hospital Assistant Steno Gr I DOJ: 08.06.1987 DOJ: 17.01.1985 DOJ: 05.05.1983 DOR: 31.01.2016 DOR: 31.01.2016 DOR: 31.01.2016
Smt. Sukumari. K Sri. Loganathan. K Jr. MRO Asst. Instructor (Mechanic) DOJ: 02.09.1985 DOJ: 27.10.1975 DOR: 29.02.2016 DOR: 29.02.2016
Sri. Nanjundappa Sri. R.Ramachandra Sri. B.N. Deshpande Hospital Assistant Office Assistant Senior Radiographer DOJ: 15.03.1979 DOJ: 23.02.1989 DOJ: 29.05.1992 DOR: 29.02.2016 DOR: 29.02.2016 DOR: 31.03.2016
Sri. S. Srinivas Sri. B.M. Veeranna Asst. Inst. (Mechanic) UDC DOJ: 25.09.1982 DOJ: 15.03.1979 DOR: 31.03.2016 DOR: 31.03.2016
Smt. Navarathnamma Sri. L.Venkoba Rao Smt. J. Mary Josephine Hospital Assistant Hospital Assistant Hospital Assistant DOJ: 20.01.1975 DOJ: 14.05.1986 DOJ: 11.10.1995 DOR: 31.03.2016 DOR: 31.03.2016 DOR: 31.03.2016 Research Collaborations
National
International
Lifting The Burden in Official Relation with the World Health Organization The Global Campaign against Headache
30 National Institute of Mental Health and Neuro Sciences Awards, Honours and Key Assignments
Biostatistics Scientific Meeting of the International Epidemiological Association 2015 (IEA-SEACON 2015), Bangkok, Thailand, 24-26 November, 2015 (ii) Best Paper Award, ‘Censored Quantile Regression based gene Dr. DK Subbakrishna, Professor, Executive Council Member, Indian signature for prognosis of Glioblastoma’, 33rd Annual Conference of Society for Medical Statistics. Indian Society for Medical Statistics, KLE University, Belagavi, 14- 16 October, 2015. Dr. K Thennarasu, Professor (i) received Fellow of Society for Medical Statistics (FSMS) award by the Indian Society for Medical Statistics, 33rd Annual Conference of Indian Society for Medical Statistics, KLE University, Belagavi, 14-16 October 2015 (ii) Member, Data Safety and Monitoring Board (DSMB) for NIH study on ‘Mental Health Integration with Primary Care in Rural Karnataka’ (iii) External expert, JIPMER Scientific Advisory Committee ( JSAC)
Mr. Ravi GS, PhD Scholar, receiving Best Paper Award at 33rd Annual Conference of Indian Society for Medical Statistics
Child and Adolescent Psychiatry
Dr. Shoba Srinath, Senior Professor, (i) Member (a) NIMHANS Governing Body and Institute body (b) Advisory Body, Jyothy Kendriya Vidyalaya (c) Governing Council, Dr. SR Chandrashekar Dr. K Thennarasu, Professor, receiving FSMS award by the Indian Society for Medical Statistics Institute of Speech and Hearing, Bengaluru (d) Board of Studies, Karnataka Parents Association of Mentally Retarded Citizens, Dr. P Marimuthu, Additional Professor, (i) received first prize for Bengaluru (e) Technical Evaluation Committee (TEC), Department presenting a paper titled ‘Effect of socio-economic differentials on of Health Research (DHR), New Delhi (f ) Visiting Professor, The growth and development of children from five metropolitan cities of Institute of Psychiatry – A Centre of Excellence, Kolkata. India’, Conference on ‘Demographics – Dividend or Disaster’, Jain University, Bangalore, January 29-30, 2016 (ii) Executive Council Dr. Satish Chandra Girimaji, Professor and Head, (i) Resource Member, International Biometric society (Indian Region) person, White Swan Foundation, Bengaluru (ii) Forum Member, World Innovation Summit Health (WISH) on Autism (iii) Member, Dr. Mariamma Philip, Assistant Professor, Chairperson, Research Core Committee, National Mental Health Survey of India. & Ethics Committee, College of Nursing, Narayana Hrudayalaya, Bangalore. Dr. Shekhar Seshadri, Professor (i) Member (a) Advisory Board for CCL NISIU (b) UGC Expert Committee on Ragging (c) Advisory Dr. B Binukumar, Assistant Professor, Life Member, International Board, Emotional Safety in Schools, Teachers Foundation (d) Biometric Society Management Committee, Richmond Fellowship- PG College (e) Governing Council, Richmond Fellowship Society, Bengaluru Branch Mr. Ravi GS, PhD Scholar, received (i) international travel grant, from (f ) Adoption Recommendation Committee, Department of Women ICMR, for attending and presenting a paper at 12th SEA Regional and Child Development, Govt. of Karnataka (g) Board of Directors,
National Institute of Mental Health and Neuro Sciences 31 Annual Report 2015-2016
Christel House Learning Centre, Bengaluru (h) Advisory Board, International Family Therapy Association (b) Society for Exploration Cambridge School, HSR Layout, Bengaluru (i) Advisory Board, of Psychotherapy Integration (c) National Board, The Richmond RAHI Delhi (ii) Secretary General, Richmond Fellowship Society, Fellowship Society (India) and attended meetings on 18 July, 2015, National Board (iii) Chairperson, House Committee and Admission 7 November 2015, 28 March 2016 (iii) scholarly affiliate, Theoretical Committee, Asha House, Richmond Fellowship Society, Bengaluru. and Philosophical Psychology, American Psychological Association (iv) International affiliate, American Psychological Association and its Dr. K John Vijay Sagar, Additional Professor, (i) received International divisions of International Psychology, Family Psychology, Personality Society for Autism Research Travel Grant to attend 1st Asia Pacific & Social Psychology, Society for Counseling Psychology, Society for Regional International Meeting for Autism Research (IMFAR), Humanistic Psychology, and Psychology of Women (v) Fellow, IACP Shanghai, China, 5-7 November 2015 (ii) Best Poster Presentation and IASP, WAPR. (co-author), title: ‘Efficacy of an Indian indicated program for adolescents at-risk for depression’, 1st International Congress of Dr. Suman LN, Professor (i) Member (a) Editorial Board, Clinical and Health Psychology with Children and Adolescents, International Journal of Psychology and Neuroscience (b) Editorial University of Miguel Hernández, Spain , 19-22 November 2015 Board, Women’s Health-Open Journal (ii) Board of Studies in (iii) Member (a) Technical Advisory Group on Adolescent Mental Psychology, National College Jayanagar, Bengaluru. Health, Ministry of Health & Family Welfare, Govt. of India (b) Editorial Board, Andhra Pradesh Journal of Psychological Medicine Dr. Paulomi M Sudhir, Additional Professor, (i) Member (a) (iv) Associate Editor, Frontiers in Child and Neurodevelopmental Data Monitoring and Safety Committee (DMSC), PREMIUM Psychiatry. randomized controlled trials of lay counsellor delivered psychological treatments for depressive disorders and harmful Dr. Sowmyashree, PhD scholar, received (i) Beacon Club Scholarship drinking in primary care, trial conducted through a partnership by World Association of Infant Mental Health 2015 (ii) International of the London School of Hygiene & Tropical Medicine, UK Society for Autism Research Travel Award to attend the International (the trial sponsor), Sangath, Goa and the Directorate of Health Meeting for Autism Research (IMFAR) 2016, Baltimore, USA. Services, Government of Goa (b) Advisory Board, PRIDE trial for psychological interventions for adolescents, a Wellcome Trust Senior Research Fellowship, conducted through a partnership of Clinical Psychology the London School of Hygiene & Tropical Medicine, UK (the trial sponsor), Sangath, Goa and the Public Health Foundation, New Dr. Mahendra P Sharma, Professor and Head, (i) Honorary President, Delhi (c) Curriculum Enhancement Board, UG and PG syllabus, Karnataka Association of Clinical Psychologists (ii) Honorary Mount Carmel College, Bengaluru. Member, Advisory Board of Resurge Academy Pvt. Ltd., Chennai (iii) Member (a) Expert Committee of Rehabilitation Council of Dr. Jamuna Rajeswaran, Additional Professor, (i) Adjunct Faculty, India (RCI) (b) Special Board of Studies in Clinical Psychology and National Institute of Advanced Studies, IISc, Bengaluru (ii) Panellist, Education Technology Programme, Pondicherry University (iv) Chief represented India and delivered a talk on the topic ‘Overcoming Guest, Hindi Workshop, Advanced Centre for Ayurveda in Mental Challenges in Developing Psychological Services in South Asia’, Health & Neuro Sciences (CCRAS), NIMHANS, Bengaluru, 7 July International Conference on Applied Psychology held at Colombo, 2015. Sri Lanka, 28-30 August 2015 (iii) Visiting Professor, RAK Medical & Health Sciences University, UAE, 29 April 2015. Dr. Ahalya Raguram, Professor, (i) Fellow of the Indian Association of Clinical Psychologists and Indian Association of Social Psychiatry Dr. Manoj Kumar Sharma, Additional Professor, (i) Psycho Oration (ii) Editorial Board Member, Telangana Journal of Psychological Award, National Annual Conference of Indian Association of Clinical Medicine. Psychologists, RIMS, Imphal, 27 March 16 (ii) Member, Ethics Committee, Advanced Centre for Yoga, NIMHANS, Bengaluru. Dr. Uma Hirisave, Professor, Member (i) Project Monitoring Committee of the project titled ‘Establishing a gifted education centre’ Dr. Manjula M, Additional Professor, (i) received Best International at NIAS, Bengaluru (ii) Project Monitoring Committee, Department Research Award (with Dr. Meghna Singhal and Dr. John Vijayasagar) of Psychology, Christ University, Bengaluru. at 1st International Congress of Clinical and Health Psychology with Children and Adolescents, University of Miguel Hernández, Madrid, Dr. Anisha Shah, Professor, (i) received best paper award for oral Spain, 19-22 November 2015 (ii) Best Paper Award (co-author), session (with Ms. Garima Srimal-Achalia), Centenary Conference 42nd National Annual Conference of IACP, Imphal, Manipur, 25- on Psychology, Kolkata, 9-11 October 2015 (ii) Member (a) 27 February 2016. (iii) Member (a) Board of Studies, Department
32 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 of Applied Psychology, Pondicherry University (b) Advisory Board Epidemiology for the project ‘PRIDE- Premium for Adolescents, Public Health Foundation of India. Dr. Gururaj G, Professor and Head, (i) Invited Member (a) International Scholarship Committee for the 13th World Conference Dr. Poornima Bhola, Associate Professor, (i) Coordinator, All- of Injury Prevention and Safety promotion, Finland, 2016 (b) Expert India Collaborative Research Network Study Group, International Group on Emergency Medical Care, National Human Rights Society for Psychotherapy Research Collaborative Research Network, Commission, Government of India, 2015 (c) Technical Resource USA (ii) Member (a) Doctoral Committee, KU Leuven University, Group in Adolescent Health, Ministry of Health and Family Belgium (b) Ethics Committee, Karunashraya Trust, Bengaluru (c) Welfare, Government of India, New Delhi (d) Technical Advisory Doctoral Committee, Tata Institute of Social Sciences, Mumbai (d) group of NCD monitoring, Indian Council of Medical Research, Ethics Sub-Committee, Indian Association of Clinical Psychologists New Delhi (e) International Editorial Board of the Journal of (e) Editorial Committee, The Journal of Psychosocial Rehabilitation Non-communicable diseases (ii) Advisor, Journal of Public Health, and Mental Health Rajiv Gandhi University of Health Sciences, Bengaluru, 2015 (iii) Conferred with Fellow of Academy of Medical Sciences (FAMS), Dr. Roopesh BN, Associate Professor, (i) Treasurer, Indian National Academy of Medical Sciences Meeting 2015, Patna, 17 Association of Clinical Psychologists (ii) Executive Secretary, October 2015. Cognitive Neuroscience Society of India (iii) Executive Member, Neuropsychological Society of India. Dr. Pradeep BS, Associate Professor, Member, Editorial Board, Journal of Public Health, Rajiv Gandhi University of Health Sciences, Dr. M Thomas Kishore, Associate Professor, (i) received Best Paper Bengaluru, 2015 Award, title: ‘Efficacy of DASII Screen in Assessing the Development of Infants in Perinatal Psychiatry Setting’, National Conference Dr. Gautham MS, Assistant Professor, (i) Chairman, Scientific on Motherhood and Mental Health, NIMHANS Bengaluru, 31 Committee, 66th Annual National Conference of Indian Association of October 2015 (ii) Member (a) International Advisory Board, Journal Occupational Health- OCCUCON-2016, NIMHANS, Bengaluru, of Intellectual Disabilities, UK (b) Expert committee on Clinical 18-20 February 2016 (ii) Mohanmal Award for Best Scientific Psychology, Rehabilitation Council of India, New Delhi. Paper presentation, Association of Occupational Health Karnataka (AOHK) State conference, Bengaluru, 4-5 July, 2015 Dr. Shantala Hegde, Assistant Professor, (i) Member, Scientific Board, International Journal of Psychology and Neuroscience (ii) awarded £1340 by the Society for Education, Music and Psychology Research (Sempre), UK.) for Music based intervention to target stress Human Genetics and cognitive dysfunction in type 2 diabetes at the Ninth Triennial Conference of the European Society for the Cognitive Sciences of Dr. Rajalakshmi Gope, Professor and Head, Member, Board Music, Manchester, UK, 17-22 August 2015 (iii) Consultant, team of Undergraduate and Postgraduate Studies in Allied Health working towards Psychological and Neurocognitive Evaluation of Sciences, Sri Devaraj Urs Academy of Higher Education and the Metro train drivers, Bangalore Metro Rail Corporation Limited Research, Kolar. (BMRCL). Dr. GK Chetan, Additional Professor, (i) Member (a) Board of Dr. Nitin Anand, Assistant Professor, Consultant, team working on Studies and Examinations, Dept. of Genetics, Bangalore University Psychological and Neurocognitive Evaluation of the Metro Train (b) Board of Studies and Examinations, Dept. of Genetics and Drivers, Bangalore Metro Rail Corporation Limited (BMRCL). Genomics, Mysore University (c) Board of Studies and Examinations, Dept. of Biochemistry, Nitte University (ii) Editorial Board Member Dr. Gitanjali Narayanan, Assistant Professor, Editorial Committee (a) Biomedical Journal, OMICS group (b) Medical Science Monitor Member, Joint Conference with Gulbenkian Global Mental Health (c) Cytotechnology. Foundation, Lisbon Portugal, and World Health Foundation, Geneva on ‘Integrating mental health care and chronic non-communicable Dr. Monojit Debnath, Assistant Professor, (i) Editorial Board disorders’, NIMHANS, Bengaluru 13-15 November 2015. Member (a) Journal of Genetics and Genome Research, ClinMed International Library, Newark, USA (b) Journal of Immunology Dr. Jyotsna Agrawal, Assistant Professor, Member, Academic and Vaccine Technology, Open Science Publications, Hyderabad (ii) Committee, Department of Clinical Psychology, LGB Regional Grant Reviewer (a) The Israel Science Foundation (b) DST-SERB, Institute of Mental Health, Tezpur. New Delhi.
National Institute of Mental Health and Neuro Sciences 33 Annual Report 2015-2016
Neuroanaesthesia Committee, Karunashraya, Hospice Trust, Bengaluru (c) Institutional Biosafety Committee, Kemwell BioPharma Pvt. Ltd., Bengaluru (d) Board of Studies, Biochemistry and Molecular Biology, Department Dr. Ramesh VJ, Professor and Head, Secretary, Indian Society of of Biochemistry, University of Mysore. Neuroanaesthesiology and Critical Care (ISNACC).
Dr. Nanda Kumar DN, Additional Professor, (i) Medical Officer and Dr. Radhakrishnan M, Additional Professor, Treasurer, Indian Society Member, Institutional Biosafety Committee (IBSC), NIMHANS (ii) of Neuroanaesthesiology and Critical Care (ISNACC). Member (a) Advisory Committee, National Urban Health Mission (b) Doctoral Committee, Department of Biotechnology, Dayanand Dr. Sriganesh K, Associate Professor, (i) Awarded ICMR International Sagar College of Engineering, Bengaluru. Fellowship (Young Scientist) 2015-16 (ii) as Hon. Secretary, Indian Society of Anaesthesiologists, Bengaluru received the Best Metro Ms. Rajini NM, PhD Scholar, received international travel grant from Branch Award 2015 and Highest Membership Drive Award 2015, IAPRD, 21st Congress on Parkinson’s disease and related disorders, National Conference of ISA, Jaipur, 29 December 2015 (iii) Secretary, Milan, Italy, December 2015. Indian Society of Anaesthesiologists, Bengaluru Branch.
Dr. Pandareesh, PDF, received a travel award from the International Dr. Sudhir V, Assistant Professor, Awarded KOPS award for the Society for Neurochemistry (ISN), for attending 25th Biennial Meeting best paper under Trauma and Critical care Retrospective study of of ISN jointly with the 13th Meeting of the Asia-Pacific Society for perioperative factors affecting neurological outcome in surgically Neurochemistry (APSN) and 35th Meeting of the Australian Society treated traumatic extradural hematoma. ISACON 2015 63rd Annual for Neurochemistry (ASN), Cairns, Queensland, Australia, 23-27 Conference of the Indian Society of Anesthesiologists, Jaipur, 25-29 August 2015. December 2015.
Dr. Sonia Bansal, Assistant Professor, received the NTSI-The Alfred Trauma Research Development Award, 24th Annual Conference of Neuro Imaging & Interventional Neurotrauma Society of India, Bengaluru, 21-23 August 2015. Radiology
Dr. Chakrabarti D, DM Student, received First Prize for poster Dr. Arun Kumar Gupta, Professor and Head, (i) Member, presentation, title: ‘Intraoperative aberrant bispectral index values due Expert Group, constituted by Medical Council of India for DM to facial nerve monitoring’, ISACON 2015, Bagalkot, October 2015. (Neuroradiology) (ii) Expert (a) Medical College Inspection for Radiology/Radiodiagnosis for MCI (b) DST to review projects (iii) Expert Assessor, National Board of Examination for Radiology/ Neurochemistry Radiodiagnosis course.
Dr. Rose Dawn Bharath, Associate Professor, Best Paper Award, Dr. Rita Christopher, Professor and Head, (i) Member (a) PhD National Conference of Indian Academy of Neurology, Agra, October Registration Committee, Rajiv Gandhi University of Health 2015 Sciences, Bengaluru (b) Board of Studies, Dayananda Sagar University, Bengaluru (c) Doctoral Committee, School of Life Sciences, Pondicherry University, Puducherry (d) Newborn Screening Committee, Ministry of Health and Family Welfare, Neurological Rehabilitation Child Heath Division (e) Institutional Biosafety Committee, Institute of Bioinformatics, Bengaluru (ii) Expert Member, review Dr. Anupam Gupta, Additional Professor, (i) Member, IFNR (Indian meeting on Newborn Screening Programme, Vani Vilas Children Federation of Neurological Rehabilitation) National Executive Hospital, Bengaluru, 19 January 2016. Committee (ii) Convener, Neurorehabilitation Sub-Section of Indian Academy of Neurology (IAN), September 2015. Dr. Sarada Subramanian, Additional Professor, Member (a) Executive Committee, Society for Neurochemists of India (SNCI) (b) Doctoral Dr. Maitreyi Patil, Senior Resident (PDF), received IAPMR Committee, VIT University, Vellore. Dadhichi Award, 44th National Conference, ‘Quality of life, cognition and functional recovery in patients with acquired brain Dr. Srinivas Bharath MM, Additional Professor, Member (a) Ethics injury following inpatient rehabilitation, Imphal, Manipur, 12-14 Committee, Rangadore Memorial Hospital, Bangalore (b) Ethics February 2016.
34 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Neurology Delhi, March 2014 (c) Governing Body, JSS Medical College, Mysore (d) Institute Body, Postgraduate Institute of Medical Education and Research, Chandigarh (vi) Expert Member, Advisory Dr. Satish Chandra P, Sr. Professor, Ex Director/Vice-Chancellor, Panel, National Academy of Medical Sciences, New Delhi (vii) Co- NIMHANS (i) Honorary Professor, Clinical Infection, Chairman, Screening Committee on Initiative of Neuroclinical Microbiology and Immunology, University of Liverpool, United Research Education (INCRE), Department of Biotechnology, Kingdom, 2015 - 2018 (ii) delivered Padmshree Thruvengangadam Government of India, New Delhi (viii) Chairman, Academic Oration on Translational research in Epilepsy: Indian Perspective, Committee, AIIMS, Bhubaneshwar (ix) Founder Member, Brain Savitha Medical College, Chennai, 10 October 2015 (iii) delivered Research Centre, Indian Institute of Science, Bangalore. 2nd SDIN Oration on Translational research in Epilepsy, Jaipur, 8 February 2016 (iv) Member (a) Board of Management, MGM Dr. Chandra SR, Professor, (i) awarded Master Teacher Award, Institute of Health Sciences, Navi Mumbai (b) Working Group on for the work done to promote neurological education in India, Equivalence, Medical Council of India, Delhi (c) Finance Committee, SHINE 2016, Chennai, 28 February 2016 (ii) received Second Best Jayadeva Institute of Cardiology, Bangalore (d) Scientific Advisory Poster Award, title: ‘Mirror agnosia and mirror image agnosia in Group(SAG), Division of Non Communicable Disease, ICMR, patients with dementia’, TSS-NIMHANS, Knowledge Conclave New Delhi (e) Governing Council, Sri Venkateshwara Institute 2016, 12-13 February 2016 (iv) Best Poster Award in Movement of Medical Sciences, Tirupathi (f ) Task Force, Indian Council for Disorders category, title: Catatonia in children following systemic Medical Research ( ICMR) (g) Advisory Board for the National illness, IANCON 2015, Agra, 1-4 October 2015 (v) Best Poster Dementia Summit, New Delhi 2010 (h) Advisory Group on Sealing Award (co-author), title: The role of T2 perfusion in therapeutic Up Mental Health, supported by World Health Organization response assessment of CNS Tuberculosis, IANCON 2015, Agra, and World Bank (i) Advisory Committee, Gulbenkian Global 1-4 October 2015. Mental Health Platform, Lisboa, Portugal (j) Scientific Advisory Committee, National Centre for Disease Informatics and Research, Dr. Pramod Kumar Pal, Professor, (i) Secretary, Movement Disorders National Cancer Registry Programme, Department of Health Society of India (ii) Editorial Board Member (a) Movement Disorders Research, Ministry of Health and Family Welfare, Government Journal (b) Hyperkinetic Movement Journal (iii) Member (a) The of India (k) Research Advisory Council, AIIMS, New Delhi (l) Education Committee of Association of Parkinsonism and Related National Advisory Board, JAPI (m) Executive Council, Institute Disorders (b) The Education Committee of Asia-Oceanic Subsection of Human Behaviour and Allied Sciences, New Delhi (n) Indian of International Parkinson and Movement Disorder Society. Council for Cultural Relations (ICCR), New Delhi (o) Academic Council, Swami Vivekananda Yoga Anusandhana Samasthana, Dr. Bindu PS, Additional Professor, received the Silver Award for Bangalore (p) Advisory Committee, Bhopal Memorial Hospital and poster presentation, title: ‘Targeted next generation sequencing in Research Centre, Bhopal (q) National Advisory Group, Ministry children with epileptic encephalopathy: A study from a tertiary of Health and Family Welfare, Government of India, New Delhi care university hospital in South India’, 17th Annual Conference of (r) MGM Journal of Medical Sciences, MGM Institute of Health Infantile Seizure Society, Tokyo, Japan, 25-26 September 2015. Sciences, Navi Mumbai (s) Genetics Commission, International League Against Epilepsy, (ILAE) USA (t) Advisory Committee, Bhopal Memorial Hospital and Research Centre, Bhopal (u) National Advisory Group, Ministry of Health and Family Welfare, Neuromicrobiology Government of India, New Delhi (v) Special Expert Committee, Department of Health Research, Delhi (w) Scientific Advisory Dr. Shripad A Patil, Professor and Head, (i) Honoured with Rajiv Committee - Partnership Programme established by DBT, New Gandhi Education Excellence Award, International Education Delhi for Advance Research in Biological Science and Engineering, Institute, New Delhi, 8 October 2015 (ii) Vice President, Department of Biological Sciences (DBS), IISc, Bangalore (x) National Indian Immunology Society (iii) Chaired meeting of (a) National Think Tank (India Backbone Implementation Network – International Infectious Disease Society, Bengaluru (b) Indian IBIN)- Planning Commission, Government of India (Secretariat, Immunology Society, Patna (c) Indian Parasitology Society, Hindu Bangalore Baptist Hospital) (y) Standing Finance Committee, All University, Banaras (d) Federation of Immunology Society of Asia India Institute of Medical Sciences, Bhubaneswar (v) Member (a) Oceania, PGI Chandigarh. Editorial Board, International Journal of Epilepsy (IJEP) (b) The High Level Advisory Committee on National Policy on Universal Dr. Ravikumar R, Professor, (i) Assessment of HIV testing laboratory Electronic accessibility constituted by Government of India, (SRL and ICTC), Kasturba Medical College, Manipal, 7 June 2015 Ministry of Communications and Information Technology, New (ii) Chaired a session on Pan India distribution of Pneumococcal
National Institute of Mental Health and Neuro Sciences 35 Annual Report 2015-2016 serotype and laboratory based pneumococcal surveillance network, 2015 (iii) Expert Member, ICMR for Neurology and Physiology (iv) ISWP-III meeting, Goa, 25-26 September 2015 (iii) Assessor, NABL Chairman, Ethics Committee of NCBS and Instem (v) President, SFN quality assessment program, HIV laboratory, JIPMER, Pondicherry, and IAN Bangalore Chapters (vi) Editorial Board Member, Journal of 27 December 2015 (iv) Member, Organizing Committee, 6th Chemical Neuroanatomy (vii) Member, Governing Body, NIMHANS. International Conference and Expo on Proteomics, Atlanta, USA 29-31 March 2016. Dr. Bindu Kutty, Professor, (i) General Secretary, ISSR (ii) Teaching faculty, National Sleep Medicine Course (iii) Adjunct faculty, NIAS (iv) Member, Expert Committee, ICMR (Translational Neuroscience Committee), and PDF Expert Committee, Cognitive Science europathology N Research Initiative (CSRI-PDF).
Prof. Shankar SK, Emeritus Professor, delivered 9th Dr. RM Varma Dr. Sathyaprabha TN, Professor, received Best Poster Presentation Oration, Lessons in the Pathogenesis of CNS Tuberculosis and Drug Award, title: Effect of carbamazepine monotherapy on electrocardiogram Resistance, Neurological Society, Bengaluru, 26 March 2016. in patient with complex partial seizure, ECON 2016, Vizag, 13-14 February 2016 (ii) Chairperson (a) MPhil Neurosciences Course, Dr. Vani Santosh, Professor and Head, (i) Fellow of the National NIMHANS (b) NIMHANS GYMKHANA Committee. Academy of Medical Sciences, New Delhi, 2015 (ii) Nominated by WHO committee to contribute to the Chapter on Subependymal Dr. Shankaranarayana Rao BS, Professor, (i) Member (a) Expert Giant Cell Astrocytoma’ in the upcoming WHO CNS4 Plus committee, Developmental Brain Disorders Program by Government edition of Tumours of Nervous system (iii) President (a) Karnataka of Kerala (b) Executive Committee, The Association of Physiologists Neuroscience Academy (b) Indian Society of Neuro-Oncology (iv) of India (c) Advisory Committee, Ministry of Communications External member, Board of Studies, Sree Chitra Tirunal Institute and Information Technology, Government of India, New Delhi for Medical Sciences and Technology, Thiruvananthapuram, 2015- (d) Institutional Human Ethics Committee, Institute of Trans- 2016 (v) Member, Committee for Stem Cell Research and Therapy disciplinary Health Sciences and Technology, Bangalore (e) Board (IC-SCRT), Indian Institute of Science, Bangalore, 2015-2016 (vi) of Studies, Dr. Ambedkar Institute of Technology, Bengaluru Treasurer, Neuropathology Society of India. (f ) Planning Committee, DST-SERB Neuroscience Schools, Department of Science and Technology, Government of India Dr. Gayathri N, Professor, (i) Member, Doctoral Committee, VIT, (g) The Indian National Node for Neuroinformatics, India (h) Vellore (ii) Member, Board of Studies, Mount Carmel College, Technical Expert Committee for the purchase of equipments for Bengaluru. Centre for Applied Genetics and Department of Zoology, Bangalore University, Bengaluru (i) Organizing Committee and Chairperson, Dr. Anita Mahadevan, Additional Professor, (i) Joint Secretary, National Symposium on Neuroscience on Recent Adavances in Neuropathology Society of India (ii) Member, Executive Committee, Neuroscience and its Application in Medical Sciences, Ravenshaw Karnataka Neurosciences Academy. University, Cuttack, Odisha, 13-14 November 2015 (j) Sectional Committee, 103rd Indian Science Congress for Medical Sciences Dr. Shilpa Rao, Sr. Resident, received Best Poster Award (2nd Prize, (including Physiology), 2015-2016 (k) Organizing Committee, Infections Category), ‘Neuropathological correlation of neuroimaging Symposium on Integrating scientific and contemplative approaches features in human rabies encephalitis’, NPSICON, Hyderabad, 19-20 to explore the mind, NIMHANS, Bengaluru, 6 December 2015 (l) December 2015. Organizing Committee, 21st International Conference on Frontiers in Yoga Research and its Applications (INCOFYRA), S-VYASA Dr. Rajalakshmi P, PDF, received Best Poster Award (Miscellaneous Yoga University, Prashanti Kutiram, Bengaluru, 3-7 January 2016 Category), ‘Neuropathological spectrum of drug resistant epilepsy (m) National Advisory Committee, and Judge for Young Scientists over a decade – an audit from a tertiary care centre’, NPSICON, Colloquium, 2nd National Conference of Association of Physiologists Hyderabad, 19-20 December 2015. of India, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, 26-29 October 2015 (ii) Chairperson (a) CME on ‘Developing skills to write a postgraduate dissertation’, Neurophysiology Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, 26 October 2015 (b) Symposium cum workshop on Dr. Raju TR, Senior Professor and Head, (i) Attended the PRC Autonomic and vascular function testing, Shri Ram Murti Smarak meeting in Physiology, ICMR, New Delhi, April 2015 (ii) Attended Institute of Medical Sciences, Bareilly, Uttar Pradesh, 26 October the PRC Meeting in Neurology, ICMR, New Delhi, 28 August 2015 (d) Distinguished Lecture and Symposium on ‘Stem Cells and
36 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Regenerative Medicine’, 5th Annual meeting of Indian Academy of Association of Physiologists and Pharmacologists of India, 24 Biomedical Sciences. Theme: Biomedical Sciences in 21st Century August 2015. and Beyond, Medanta – The Medicity, New Delhi, 26-28 February 2016 (iii) Secretary, Indian Academy of Neurosciences, Bengaluru Ms. Pooja Shree Mishra, PhD Scholar, received travel grant from (a) Branch (iv) Treasurer, Society for Neuroscience, Bengaluru Chapter the Department of Biotechnology, Govt. of India and FENS-SfN (v) Served in the editorial boards of the following journals (a) stipend for registration to attend FENS-SfN Summer School 2015, Executive Editor, Neuroscience Research Letters (b) Editor, Shared mechanisms and specificity in neurodegenerative diseases, Prudence Journal of Medicine and Medical Sciences (c) Member, Bertinoro, Training Center of the University of Bologna, Italy, May Metabolic Brain Disease (d) Member, Journal of Natural Science, 2015 (b) Indian Council of Medical Research, Govt. of India to attend Biology and Medicine (e) Member, International Journal of Modern 45th Annual Meeting – Neuroscience 2015, Society for Neuroscience and Alternative Medicine Research (f ) Member, Journal of Krishna (SfN), Chicago, October 2015. Institute of Medical Sciences University (g) Advisory Board Member, Bioinfo Publications (h) Editorial Advisory Board Member, Journal Ms. Suwarna Chakraborty, PhD Scholar, received Dr. DM Kar Prize, of Pharmaceutical and Biological Sciences (i) Member, Trends in 33rd Annual Conference of Indian Academy of Neurosciences (IAN), Biotechnology Research (j) Member, Science Discovery (k) Member, Panjab University, Chandigarh, 31 October - 2 November 2015. International Journal of Molecular Biology and Biochemistry (l) Member, Journal of Cell and Tissue Research (m) Member, The ASSOPI Journal of Physiology.
Dr. Laxmi T Rao, Additional Professor, (i) Secretary, APPI Bengaluru Chapter—received Best Branch Award, 61st Annual Conference of APPI, AIIMS, Jodhpur, 26-28 November 2015 (ii) Member (a) Editorial Advisory Board, Annals of Neuroscience, Karger Publications (b) Life Science Research Board (LSRB), DRDO, New Delhi (c) University Grants Commission (UGC), Advisory Committee of Center with Potential for Excellence in a Particular Area (CPEPA) of University of Calcutta (d) Life Science Research Board (LSRB)- Ms. Suwarna Chakraborty receiving Dr. D.M. Kar Prize from Dr. Girish Sahni, DRDO, New Delhi (e) Society for Neuroscience (SfN), USA (iii) Director General, Council of Scientific and Industrial Research (CSIR) and Secretary, APPI-Bengaluru Chapter (iv) Executive Member (a) Indian Secretary, Department for Scientific & Industrial Research (DSIR) Academy of Neuroscience (IAN) (b) Society for Neuroscience (SFN) – Bengaluru Chapter (v) Life Member, The Indian Society for Sleep Mr. Vidyadhara DJ, PhD Scholar, received travel grant from the Research (ISSR) and Asian Society for Sleep Research. Department of Science and Technology, Govt. of India to attend the 45th Annual Meeting of Society for Neuroscience, Chicago, USA, 17- Dr. Vijayalakshmi K, Assistant Professor, Reviewer, the Indian Journal 21 October 2015. of Physiology and Pharmacology.
Dr. Srikumar BN, Assistant Professor, Expert-Referee, Science and Neurosurgery Engineering Research Board, DST, Government of India. Dr. Indira Devi B, Professor, (i) Organising Secretary, Neurotrauma Dr. Phalguni Anand Alladi, SSO, (i) received international travel 2015 (ii) Member (a) WFNS Committee on Peripheral Nerves (b) support from Science and Engineering Research Board, DST, Govt. Library Committee, NIMHANS (c) Animal Ethics Committee, of India to attend the 19th International Congress of Parkinson’s NIMHANS. Disease and Movement Disorders, San Diego, California, USA, 14- 18 June 2015 (ii) received registration fees award of US$600 from Dr. Malla Bhaskara Rao, Professor, (i) Member (a) Executive the International Parkinson’s and Movement Disorder Society, USA Committee, Neurological Society of India (NSI) (b) Executive to attend the 19th International Congress of Parkinson’s Disease and Committee, Indian Epilepsy Society (IES) (ii) Secretary, Indian Movement Disorders, San Diego, California, USA, 14-18 June 2015 Society for Stereotactic and Functional Neurosurgery (ISSFN). (iii) Expert, Neuroscience Task Force of the DBT, India. Dr. Dhananjay Bhat I, Additional Professor, Faculty (a) 8th NSI Ms. Jyothi HJ, JRF and Mr. Vidyadhara DJ, PhD Scholar, received Educational Course, Lucknow, August 2015 (b) 9th NSI Educational BK Anand Award for Best Paper in Physiology for the year 2015, Course, Mumbai, January 2016.
National Institute of Mental Health and Neuro Sciences 37 Annual Report 2015-2016
Dr. Dwarakanath D, Additional Professor, Executive Committee Puducherry (b) Academic Committee, AIIMS, Raipur (c) Standing Member (a) Indian Society of Paediatric Neurosurgery (b) Indian Finance Committee, AIIMS, Raipur (d) Institute Body, AIIMS, Society of Stereotactic and Functional Neurosurgery. Raipur (e) Academic Committee, NIMHANS (f ) Standing Finance Committee, NIMHANS (g) Institute Body, NIMHANS Dr. Narasinga Rao KVL, Additional Professor, Member, Executive (v) Registrar, NIMHANS (until 31 July 2015) (vi) Dean of Basic Committee, APNSA, India. Sciences and Controller of Examinations, NIMHANS (vii) NABL Assessor- carried out two assessments for NABL in 2015-16. Dr. Dhaval Shukla, Additional Professor, (i) received (a) Best Poster Award, Annual Conference of Neurotrauma Society of India, Dr. Anita Desai, Professor, (i) WHO Consultant, WHO-SEARO, Bengaluru, 2015 (b) Best Poster Award, Conference of Indian Society to provide training to strengthen laboratory capacity for cell culture of Neurosanesthesiology and Critical Care, Bengaluru, 2016. of Influenza laboratory at Medical Research Institute, Colombo, Sri Lanka (ii) Member, Expert Group on Communicable Diseases Dr. Vikas V, Associate Professor, (i) Member (a) Karnataka State to review fellowship proposals and reports, ICMR, New Delhi (iii) Board, IMA (b) Election Commission, Karnataka State Board, IMA CDC nominated assessor of laboratories for Sexually Transmitted (c) Executive Committee, NIMHANS Faculty Association. Diseases (assessed RSSTI laboratory, PGIMER, Chandigarh and RSSTI, MS Medical College, Gujarat). Dr. Prabhuraj AR, Assistant Professor, received Best Poster Award, NSICON 2015, Hyderabad. Dr. Reeta Mani, Associate Professor, participated in the Rabies WHO Collaborating Centres Meeting, WHO Headquarters, Geneva, Dr. Amey S, Assistant Professor, Awarded, Best Paper Award, Skull Switzerland, 9 December 2015. Base Conference 2016, Bangalore.
Dr. Satyakam Baruah, Sr. Resident, (i) was chosen as a Prime Nursing Minister’s Guest at Republic Day parade at New Delhi 2016 as one of the 100 meritorious students for academic excellence in Neurosurgery Dr. K. Lalitha, Professor, (i) NAAC Member (a) inspected Homi (ii) received the Best Paper Award (Neurosurgery) for ‘Can Cortical Bhabha National Institute, Mumbai, for accreditation, 25 April - Reorganisation Explain the Cause and Relief of Dysesthetic Pain: An 2nd May 2015 (b) inspected Sri Balaji Vidyapeeth, Pondicherry for fMRI Study’, NSI 2015. accreditation, 2-5 November, 2015 (c) inspected Colleges of Nursing, affiliated to Pondicherry University, Puducherry for accreditation, 21- Dr. Kislay Kishore, Sr. Resident, awarded ICMR Travel Fellowship to 23 March 2016 (ii) Member Fhi360 Team, for preparing a video on Prague, Czech Republic to present a paper titled ‘Hemangiopericytoma: Teaching Methodologies (iii) IGNOU Doctoral Committee meeting, Analysis of Series of 41 Patients to Determine Best Management New Delhi (a) 29-30 June 2015 (b) 4 January 2016 (iv) Guest of Strategy’. Honor, LUCEAT 2015, Lamp Lighting and Graduation ceremony, Universal College & School of Nursing, Bengaluru, 19 December Dr. Harsh Deora, MCh, received Best Paper Award, Neurovascon 2015 (v) Chief Guest, ‘GRADUATIE 2016’, St. Philomena’s College 2015, Bengaluru. of Nursing, Bengaluru, 27 February 2016 (vi) Special Online Adviser /subject expert for UPSC Empanelment.
Neurovirology Dr. Ramachandra, Additional Professor and Head, Moderator, Curriculum Convention, Manipal College of Nursing, Manipal, 24 Dr. V Ravi, Professor and Head, (i) received the prestigious September 2015. international Global Health Security Agenda grant of US$ 1.6 million per year for three years from CDC, USA (title: Providing Dr. Sailaxmi Gandhi, Associate Professor, (i) Invited expert (a) laboratory support for surveillance of Japanese encephalitis in India) stakeholders event to discuss continuing professional development (ii) Invited Expert, WHO Bi-Regional Workshop on Strengthening needs of nurses working in the periphery at St Johns Medical College the Capacity of Japanese Encephalitis ( JE) Laboratory Network in Research Center, 22 July 2015 (b) Advisory Board Meeting of IJCNE, the WHO South-East Asia and Western Pacific Region, Bangkok, CMC College of Nursing, Vellore, 31 October 2015 (ii) Invited judge Thailand, 17-21 August 2015 (iii) invited to participate in the First (a) poster presentation, National Conference on Motherhood and Global health Security Agenda Meeting, CDC, Atlanta, USA, 10- Mental Health, MMH 2015, NIMHANS, Bengaluru, 31 October 12 February 2016 (iv) Member (a) Academic Council, JIPMER, 2015 (b) poster presentation, Satellite Conference of Neurotrauma
38 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Nursing 2015 and the 24th Annual Conference of NTSI 2015, Sciences (NIAS), Bengaluru, (iv) Co-editor, Asian Journal of NIMHANS Convention Centre, Bengaluru, 21-23 August 2015 (iii) Psychiatry (v) Organising Committee Member, International Member, editorial board (local), Journal of Psychosocial Rehabilitation Conference on Yoga Research and Applications, SVYASA, Bengaluru and Mental Health (iv) Member, Doctoral Committee, SRM College and delivered Keynote Address on Yoga and Psychiatric Disorders, of Nursing, Chennai. (vi) Dean, SVYASA University (till 11 January 2016).
Mrs. Deepa Jose, Staff Nurse (Pavilion IV, Psychiatry Wing), received Dr. Prabha S Chandra, Professor, (i) Fellow of the Academy of Best Nurse Award, International Nurses Day 2015, NIMHANS, Medical Sciences, India (ii) Secretary, International Association Bengaluru, 15 May 2015. of Women’s Mental Health (iii) Nominated member, Publications Committee, World Psychiatric Association (iv) Chairperson (a) Smt. Jayalakshmi Antharaj, Staff Nurse (Neuro Surgical Intensive Ethics Committee, Centre for Public Policy, IIM, Bengaluru (b) Care Unit, Neuro Centre) received Best Nurse Award, International Specialty Sections on Perinatal Psychiatry of Indian Psychiatric Nurses Day 2015, NIMHANS, Bengaluru, 15 May 2015. Society (v) Member (a) Advisory Board, White Swan Foundation for Mental Health (b) Advisory Group, PreVAiL Research Network: Smt. Tejeswini, Staff Nurse (Casualty Block) received Best Nurse A Canadian Institute of Health Research Centre for Research Award, International Nurses Day 2015, NIMHANS, Bengaluru, 15 Development on Gender, Mental Health and Violence Across the May 2015. Lifespan, Toronto, Canada
Dr. Pratima Murthy, Professor, (i) Fellow of the Indian Academy College of Nursing of Medical Sciences, April 2015 (ii) Fellow of the Royal College of Physicians, Glasgow, June 2015 (iii) Member (a) National Human Rights Commission, Advisory Group on Health, January 2015 (b) Dr. BV Kathyayani, Principal, Member (a) Board of Studies, Texila National Human Rights Commission, Technical Group to advise American University (b) National Indian Pharmacopoeia Commission on mental health in India to appraise the Hon’ble Supreme Court (c) Alzheimer’s and Related Disorders Society of India (ARDSI). regarding the deficiencies prevailing in the area of mental health in the country, June 2015 (c) TRG Resource Group on adolescent health Dr. Pratibha Swamy, Associate Professor, Editorial Board Member sub-thematic specialty for addiction, Ministry of Health and Family (a) International Journal of Oncological Nursing (b) International Welfare, Govt. of India, September 2015 (iv) Dr. Mangalvedhe Journal of Critical Care Nursing. Memorial Oration, ‘Alcohol Dependence - The how and why?’, IMA Hubli, 4 April 2015 (v) Maurice Bloch Lecture, ‘Addiction treatment Mrs. P Vijayalakshmi, Clinical Instructor, (i) Mental Health Nurse in India-bridging chasms, not just gaps,’ University of Glasgow, of the Year Award (II Place) by British journal of Nursing, March November 2015. 2016 (ii) Associate Editor, Indian Journal of Psychiatric Nursing (iii) Member (a) Advisory Board, Canadian Journal of Nursing Research Dr. Srikala Bharath, Professor, Vice Chair - South Asian Division, (b) Editorial Board, International Archives of Nursing and Health Royal College of Psychiatrists (UK). Care Journal
Dr. YC Janardhan Reddy, Professor, (i) Scholar, International Society of Bipolar Disorders (ISBD), 2015 (ii) Member, WHO International Psychiatry Advisory Group for Revision of ICD-10 Mental and Behavioral Disorders: Working Group on the Classification of Obsessive- Dr. BN Gangadhar, Director, NIMHANS and Professor of Compulsive and Related Disorders. Psychiatry, (i) Chairman (a) UGC, Psychology Syllabus Revision Committee, Government of India, New Delhi (b) Yoga Meditation Dr. Vivek Benegal, Professor, (i) WHO – ISAM Fellowship For Section of Indian Psychiatric Society (ii) Member (a) CSIR Sathyam Physicians 2015 (ii) Newton Bhabha Award (2015) of the Medical Program, Government of India, New Delhi (b) DST- Cognitive Research Council UK and ICMR India (iii) Advisor, Expert Scientific Science Initiative (CSI) Program Committee, Government of India, meeting on the Harms to Health due to Cannabis Use, Stockholm, New Delhi (c) ICMR - Advisory Committee on Mental Health, Sweden, April 2015 (iv) Member (a) Scientific Committee, Government of India, New Delhi (d) Selection Committee, Sri Momentum for change: research and advocacy reducing alcohol harm: Sri University, Bhubaneswar, Orissa (e) Ethics Committee, IISc, Global Alcohol Policy Conference (GAPC 2015), Edinburgh (b) Bengaluru (f ) Advisory Committee of Centre for Brain Research, Review Panel, Researcher Training Fellowship for Clinicians scheme, IISc, Bengaluru (iii) Adjunct Faculty, National Institute of Advanced The Wellcome Trust DBT India Alliance Fellowship.
National Institute of Mental Health and Neuro Sciences 39 Annual Report 2015-2016
Dr. Jagadisha Thirthalli, Professor, attended the meeting convened by Dr. T Sivakumar, Assistant Professor, (i) Initiated Virtual Knowledge the Director General of Health Services to examine the report of the Network NIMHANS ECHO: Road to recovery with teams from ‘Technical Committee on Mental Health’ constituted by NHRC to Psychiatric Rehabilitation Services, Centre for Addiction Medicine evaluate mental health services in India’ New Delhi, 8 March 2016. and VKN NIMHANS ECHO (ii) attended meetings at Directorate for Empowerment of Differently Abled and Senior Citizens, Dr. G Venkatasubramanian, Additional Professor, received the Government of Karnataka for identification of posts for persons prestigious ‘Swarna Jayanthi Fellowship Award (Life Sciences)’ by the with disability (iii) Coordinator (a) Art Competition, World Mental Department of Science and Technology, New Delhi. Health Day 2015, 4 November 2015 (b) Participation of NIMHANS team in Bangalore Rehabilitation Cricket League organized by Dr. P T Sivakumar, Additional Professor, (i) Vice President, Alzheimer’s Medico-Pastoral Association, 15 October 2015 (iv) Member, Medical and Related Disorders Society of India- Bangalore Chapter (ii) Direct Authority, NIMHANS, Bengaluru (v) Associate Editor and Editorial Member, Executive Committee, Indian Association for Geriatric Board (Local) Member, Journal of Psychosocial Rehabilitation & Mental Health (iii) Convenor, Indian Association for Geriatric Mental Health. Mental Health Task force for Position statement on Geriatric Mental Health policy in India. Dr. Aarti Jagannathan, Assistant Professor, Department of Psychiatric Social Work, (i) Participant in the online discussion organized by Dr. Prabhat Kumar Chand, Additional Professor, (i) received 1st Prize UNESCO on ‘Inclusive Technical and Vocational Education and for Oral Paper Presentation, International Congress of Telemedicine Training (TVET) in the context of Lifelong learning skills for work 2015, Telemedicine Society of India, Kolkata, 27-29 November 2015 and life: Empowering people with disabilities, 29 October 2015 – (ii) Member, Substance Use Specialty Section, Indian Psychiatric 18 November 2015 (ii) Knowledge Expert, Task Force for creating Society (iii) Founder Member and Co-ordinator, Virtual Knowledge advisory note for the different qualification packs (job roles) for Network NIMHANS ECHO. Skill Council for Persons with Disability (SCPwD), National Skill Development Corporation (NSDC), New Delhi (iii) Networking Dr. Santosh Loganathan, Associate Professor, Supervision of trainers with corporate for vocational rehabilitation: Teamlease, Star bazaar, in the State of Rajasthan for National Mental Health Survey Big Bazaar, Enable India, SAP Labs, Delhi Freight Couriers (iv) (NMHS), November 2015. Preparation of proposal for skills empanelment, Ministry of Social Justice and Empowerment, Government of India (v) attended Dr. V Senthil Kumar Reddi, Associate Professor, received the Fogarty meetings of Directorate of Disability, Government of Karnataka on Fellowship for the study on Functional Imaging in Psychiatric and job reservation for the disabled, May 2015 – March 2016. Behavioural Disorders from the University of Florida, Gainesville, US Dr. Hareesh Angothu, Assistant Professor, attending meetings Dr. Naveen Kumar C, Associate Professor received the Tilak Venkoba of Department of Disabled and Senior Citizens, Government of Rao Oration Award-2015, ANCIPS-2016, Bhopal, 21-24 January 2016. Karnataka on identification of posts to be reserved for persons with mental illness and mental retardation. Dr. TS Jaisoorya, Assistant Professor, Technical Consultant, DISHA, the Kerala State 24-hour Telephone Helpline Psychiatric Social Work
Psychiatric Rehabilitation Dr. K Sekar, Professor & Registrar, NIMHANS, (i) Member (a) Functioning and Disability Reference Group (FDRG), CBHI, Dr. SK Chaturvedi, Professor, (i) appointed Dean, Behavioural India Country Coordinating Centre, Directorate General of Health Sciences, NIMHANS January 2016 (ii) Editor-in-Chief, Journal of Services for WHO-ICF and FIC (b) Development of Manual for Psychosocial Rehabilitation & Mental Health, Springer Publications, Social Workers under NMHP 2016, Ministry of Health & Family 2015 (iii) Member Secretary, Dr. Ramachandra N Moorthy Welfare, Govt. of India (c) Academic Council, National Institute Foundation for Mental Health & Neurological Sciences, NIMHANS, of Locomotor Disability, Hyderabad (d) Academic Committee, Bengaluru. Central University of Kerala, Kannur (ii) Trustee, Child Rights and Sustainability Trust, Bengaluru. Dr. Krishna Prasad, Associate Professor, Reviewer, training of FDCs of National Mental Health Survey in the state of Madhya Pradesh, Dr. Muralidhar D, Professor, (i) Honorary President, Indian AIIMS Bhopal, 4-10 October 2015. Professional Social Work Association, 2016-2018 (ii) Board Member,
40 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Jeeva, an NGO working for Transgender Community (iii) Member, Coordinator, SCARF, Role of Psychiatric Social Workers in a Jeevodaya Hospice, Chennai. Rehabilitation Setting, Chennai, 14 March-19 March 2016 (vii) Networking with Tata Institute of Social Sciences (TISS), School Dr. Krishna Reddy N, Additional Professor, (i) Vice President, of Social Work, and Disability Studies for exchange of learning, Indian Society of Professional Work (ISPSW), 34th Annual knowledge and projects (viii) Assistant Editor, Editorial Board (a) Conference, Central University Rajasthan (ii) Member (a) BOS, Yoga Sudha (Sep 2013 onwards) (b) Austin Journal of Psychiatry Department of Social Work, Kuvempu University, Karnataka and and Behavioral Sciences (2015 onwards) (c) Samathvam (d) National Department of Social Work, Sri Krishnadevaraya University, Andhra Journal of Professional Social Work (2016 onwards) (ix) participated Pradesh (b) Doctoral Committee, Department of Social Work, Sri in the online discussion organized by the United Nations Educational, Krishnadevaraya University, Andhra Pradesh. Scientific & Cultural Organization (UNESCO) on building Inclusive Societies for Persons with disabilities, titled: ‘Inclusive Technical and Dr. R Dhanasekara Pandian, Additional Professor, (i) Chairperson, Vocational Education and Training (TVET) in the context of lifelong Scientific Session, 3rd Indian Social Work Congress-2015, Jain Vishva learning skills for work and life: Empowering people with disabilities’, Bharati Institute, Rajasthan, 24-26 October 2015 (ii) Special Guest, 29 October-18 November 2015 (ii) World Social Work Day: Promoting the dignity and worth of people, Department of Social Work, Sri Padmavati Mahila Visvavidyalayam, Dr. Vranda, Assistant Professor, (i) Executive Member, Indian Society Tirupati, 15 March 2016 (iii) Chairperson, Scientific Session, 34th of Professional Social Workers (ISPSWs) 2016 (ii) Member, joint Annual National Conference of the Indian Society of Professional visit to Ranchi Institute of Mental Health & Neuro Sciences, Ranchi, Social Work (ISPSW), Central University, Rajasthan, 24-26 February along with National Commission for Women, New Delhi to address 2016 (iv) Expert Working Group Member, National Mental Health the concerns of women admitted to psychiatric institutions of India, Program (NMHP), New Delhi, 2016 to formulate a draft of training 21-22 January 2016. module in psychiatry for social workers posted at the peripheral public health centres in India (v) Honorary Treasurer, India Network of Professional Social Workers Associations (INPSWA) (vi) Honorary Psychopharmacology General Secretary, Indian Society of Professional Social Work (ISPSW) (vii) Member (a) Academic Council, Madurai Institute of Dr. Chittaranjan Andrade, Professor, Chairman, Indian Psychiatric Social Sciences, Madurai (b) Dr. Ramachandra Moorthy Foundation, Society Task Force on Psychopharmacology NIMHANS, Bengaluru (c) National Mental Health Survey (NMHS).
Dr. Ameer Hamza, Additional Professor, (i) Member (a) Institutional Speech Pathology and Audiology Ethics Committee for Bio-Medical Research, National Institute of Unani Medicine, Bangalore (b) National Mental Health Survey Dr. Jayaram, Sr. Professor, Chairman, Expert Group on Speech and (NMHS), in-charge of two states (Gujarat and Rajasthan) (ii) Vice- Hearing: Rehabilitation Council of India. president, Indian Society of Professional Social Work (ISPSW). Dr. N Shivashankar, Professor, Chairman, Seva-in-Action, Bengaluru. Dr. Nirmala BP, Additional Professor, Executive Member, Indian Society of Professional Social Work (ISPSW). Dr. Meera SS, Speech Therapist, (i) Member, Advisory Committee, Latika Roy Foundation, Dehradun, India. (ii) received travel award Dr. Aarti Jaganathan, Assistant Professor, (i) Knowledge Expert, Task from the International Society for Autism Research (INSAR) to Force for creating advisory note for the different qualification packs attend the International Meeting for Autism Research (IMFAR) - (job roles) for Skill Council for Persons with Disability (SCPwD), 2015, Salt Lake City, Utah, USA. National Skill Development Corporation (NSDC), New Delhi (ii) Coordinator, Volunteers e-groups and connecting volunteers for various activities in PRS (iii) Preparation of proposal for skills Clinical Neurosciences empanelment to Ministry of Social Justice and Empowerment (iv) Member, committee from NIMHANS to attend meetings convened Dr. Soundarya S, Jr. Resident (i) received Travel fellowship from by the Directorate of Disability, Govt. of Karnataka with regard to Science and Engineering Research Board (SERB) to attend Gordon reservation schemes for disabled meeting, May 2015 - March 2016 Research conference – Texas USA (ii) Co-Editor, background (v) Member, Board of the Information Centre (NIMHANS) – Seva document prepared for the symposium ‘Integrating Mental Health in Action – Directorate of Disability, Govt. of Karnataka, Committee Care and Non-communicable Disorders’, The Gulbenkian Mental Meeting, 19 & 30 March 2016 (vi) Mentoring of Observer/Project Health Platform and NIMHANS, November 2015 .
National Institute of Mental Health and Neuro Sciences 41 Annual Report 2015-2016
Dr. Sowmyashree Mayur Kaku, Sr. Resident, (i) Beacon Club the University of Freiburg for participating in the 2nd International Scholarship by World Association of Infant Mental Health 2015 (ii) Workshop on High Frequency Oscillations in Epilepsy, Germany, received travel award from International Society for Autism Research March 2016. to attend the International Meeting for Autism Research (IMFAR) 2016, Baltimore, USA Dr. Mrunal Bandawar, Dual PhD Fellow, received conference bursary for (a) attending United Kingdom Society of Behavioral Medicine Dr. Chetan S Nayak, Sr. Resident (i) awarded International League Annual Meeting, New Castle, UK, December, 2015 (b) attending Against Epilepsy (ILAE) educational bursary to participate in the UKCTAS Early Carrier Conference, Bristol, September, 2015 (c) Virtual Epilepsy Academy (VIREPA) online course on ‘EEG in the UKCRC Conference, Edinburgh, Scotland, November, 2015. diagnosis and management of epilepsy, 2nd Edition 2015-2016 (ii) received ACIAN Trust travel bursary for attending 31st International Dr. Abhishek Lenka, PhD Fellow, received travel grant from Epilepsy Congress (IEC), Istanbul, Turkey, September 2015 (iii) International Association of Parkinsonism and Related Disorders International League Against Epilepsy (ILAE) ‘Young Investigator’s (IAPARD) to attend the XXI World Congress on Parkinson’s Disease Award’ and ‘Best Poster’ at the ‘31st International Epilepsy Congress and Movement Disorders, Milan, Italy, December 2015 (IEC) – September 2015’ at Istanbul, Turkey for presentation of a poster titled ‘Effect of valproate on the sleep microstructure of Dr. Ragasudha Botta, PhD Fellow, (i) Travel grant from International patients with juvenile myoclonic epilepsy’ (iv) International travel Parkinson and Movement Disorder Society – Asia Oceania Section, grant from Department of Science & Technology (DST), Ministry Dubai, UAE, November, 2015 (ii) Best Poster Award, title: ‘Study of Health & Family Welfare, Govt. of India to attend Neuroscience of Sleep Architecture, Cognition and Neurochemical Correlates in 2015, the 45th Annual Meeting of the Society for Neuroscience at Parkinson’s Disease and other Atypical Parkinsonism’, 1st Conference Chicago, Illinois. of the Movement Disorders Society of India (MDSICON), Chennai, January 2016. Dr. Velmurugan Jayabal, Sr. Resident, received (a) international travel grant from CSIR (Council of Scientific & Industrial Dr. Albert Stezin, PhD Fellow, (i) received travel grant from Research) for participating in Human Brain Mapping Conference, International Association of Parkinsonism and Related Disorders Miami, USA, June 2015 (b) ILAE (International League against (IAPARD) to attend the XXI World Congress on Parkinson’s Disease Epilepsy) bursary award for participating in advanced EEG and Movement Disorders, Milan, Italy, December 2015 VIREPA (Virtual Epilepsy Academy) course, September 2015 (c) Suzanne and Peter Berry international travel award for participating Dr. Preethish Kumar V, Jr. Resident, received ICMR Travel Award and presenting research work in American Epilepsy Society Annual to attend 67th Annual Meet of American Academy of Neurology, Meeting, Philadelphia, USA, December 2015 (d) Travel grant from Washington DC, USA, 18-25 April 2015.
42 National Institute of Mental Health and Neuro Sciences Jasmine Mary John Visitors to NIMHANS
Dr. Lokesh B, Sr. Consultant, Dept. of Neurology, BGS Hospital, visited NIMHANS and delivered a lecture, ‘Decision making in cerebrovascular disorders: Role of transcranial sonography’, 7 April 2015
Mr. Hanuman Marur, PE, Trans Environmental Engineers, Michigan, visited the Psychiatric Rehabilitation Services unit, 10 April 2015.
Dr. SK Kiran Kumar, Professor, University of Mysore, visited the Dept. of Clinical Psychology and delivered a lecture, ‘Indian Psychology’, 15-18 April 2015.
Prof. CV Vishveshwara, renowned scientist and one of the pioneers in black hole physics, visited NIMHANS and delivered a talk, ‘Subtle is the Lord… The Legacy of Albert Einstein’ as a part of Wellcome Shri. SC Sinha, Member, National Human Rights Commission (NHRC) Project, 20 April 2015. Dr. T Mohan, Deputy Director (Rehabilitation), Vocational Rehabilitation Centre, and team, visited the Psychiatric Rehabilitation Services unit, 3 June 2015.
Dr. Huu Kim Le, Child Psychiatrist, Sydney, Australia, visited the NCWB and SHUT Clinic, 6 June 2015.
Dr. Sunil Anand, Executive Director, Project ECHO, and team visited the Virtual Learning Centre, Centre for Addiction Medicine, and the Dept. of Psychiatry, and delivered a lecture, ‘ECHO model of health care connecting academic centre to community, 16 June 2015.
Renowned scientist Prof. CV Vishveshwara Prof. Hayden Mc Robbie, Adjunct Professor, Faculty of Health and Dr. Sanjeeva, Assistant Professor, Indira Gandhi Institute of Child Environmental Sciences, Auckland University of Technology, New Health, Bangalore, visited the Dept. of Child and Adolescent Zealand, visited the Dept. of Psychiatry and delivered a lecture, Psychiatry and delivered a lecture, ‘PEP Prophylaxis following Non- ‘Pharmacological intervention in Tobacco Cessation’, 17 June 2015. Occupational Exposure’, 21 April 2015. Dr. Dilip V Jeste, Distinguished Professor of Psychiatry and Ms. Chetna Duggal, Assistant Professor, Centre for Human Ecology, Neurosciences, University of California, San Diego, USA, visited the Tata Institute of Social Sciences, Mumbai, visited the Dept. of Clinical Dept. of Psychiatry and NIMHANS Integrated Centre for Yoga, Psychology and delivered a talk, ‘Creating a niche for psychologists in and delivered a talk, ‘Importance of Yoga in Healthy Aging and varied contexts: Perspective of a trainer/supervisor’, 1 May 2015. Wellbeing’, 29 June 2015.
Shri. SC Sinha, Member, National Human Rights Commission Prof. Emiliop Perucca, Epileptologist and Professor, University of (NHRC), visited the Psychiatric Rehabilitation Services unit, 22 May Pavia, Italy, visited the Dept. of Neurology and delivered a lecture, 2015. ‘Challenges in the treatment of epilepsy’, 6 July 2015.
44 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Prof. Emiliop Perucca, Epileptologist and Professor, University of Pavia, Italy Dr. Lawrence Cohen, Professor of Anthropology and South & Southeast Asian Studies, University of California, Berkeley, USA. Dr. Sarah Pinto, Associate Professor, Department of Anthropology, Tufts University, USA, visited the Dept. of Psychiatry and delivered Prof. Pierre Genton, Centre Saint Paul, Marseille, France, visited the a lecture, ‘History of hysteria in India: The transnational history of a Dept. of Neurology and delivered a lecture, ‘Epileptic encephalopathies: medical idea’, 6 July 2015. From childhood to adulthood’, 31 July 2015.
Dr. Sarah Pinto, Associate Professor, Department of Anthropology, Tufts University, USA Prof. Pierre Genton, Centre Saint Paul, Marseille, France
Dr. Mayank Goyal, Calgary, Canada, visited the Dept. of Dr. Scott A Vota, Associate Professor, Interim-Chair, Department Neuroimaging and Interventional Radiology and delivered a talk, of Neurology, Virginia Commonwealth University Medical Center, ‘Acute stroke interventions’, 14 July 2015. Virginia, visited the Dept. of Neurology and delivered a lecture, ‘Ultrasonography in Neuromuscular Disorders’, 4 August 2015. Dr. Preeti Singh, Senior Consultant Clinical Psychologist, Paras Hospitals, Gurgaon, visited the Dept. of Clinical Psychology, 17 July Dr. N Sreekumaran Nair, Professor & Head, Department of Statistics, 2015. Manipal University, Manipal, visited the Dept. of Biostatistics and delivered a lecture, ‘Biostatistics in medical and behavioral research: Dr. Lawrence Cohen, Professor of Anthropology and South & Career opportunities’, 10 August 2015. Southeast Asian Studies, University of California, Berkeley, USA; Dr. Andrew C Willford, Professor of Anthropology, Cornell University, Prof. Krishna Misra, NASI-Reliance Platinum Jubilee Senior Scientist USA; Lucinda Ramberg, Assistant Professor of Anthropology and and Honorary Professor, Center of Biomedical Research, Lucknow, Feminist, Gender, and Sexuality Studies at Cornell University, USA; and Coordinator, Indo-Russian Center for Biotechnology, IIIT-A, and Dr. Vandana Gopikumar, Professor, Social Work Practice, Tata Jhalwa Campus, Allahabad, visited the Dept. of Neurochemistry and Institute of Social Sciences (TISS) visited the Dept. of Psychiatry and delivered a lecture, ‘Enhancing therapeutic potential and bioavailability took part in the discussion/seminar, ‘Anthropological Perspective in of curcumin through chemical modification, a computation based Health Care’, 23 July 2015. approach’, 12 August 2015.
National Institute of Mental Health and Neuro Sciences 45 Annual Report 2015-2016
Dr. Manjunath Prasad, Consultant Neurosurgery, South Tees Hospitals Lt. Col. Dr. Sameer Mehrotra, Associate Professor, AFMC, Pune Trust, NHS, UK, visited the Dept. of Neuroanaesthesia, 23 August 2015. visited the Psychiatric Rehabilitation Services unit, 13 October 2015. Prof. Suptendra Nath Sarbadhikari, Project Director, National Health Dr. Savithri Rangarajan, Business Development and Support, Portal, Centre for Health Informatics (CHI), National Institute of PamGene International B.V., The Netherlands, visited the Dept. of Health and Family Welfare, Government of India, New Delhi, visited Neurochemistry and delivered a lecture, ‘Applications of PamGene’s the Dept. of Psychiatry and delivered a lecture, ‘Scope of e-Learning novel, multiplex kinase activity profiling technology in neurobiology’, and Clinical Decision Support System (CDSS) in Mental Health’, 25 August 2015. 16-17 October 2015.
Dr. Sangeetha Nath, Senior Research Engineer, Division of Geriatrics, Dr. Jane Fisher, Jean Hailes Professor of Women’s Health and Director Linköping University Sweden, visited the Dept. of Neurophysiology Jean Hailes Research Unit, Monash University, Australia, visited the and delivered a lecture, ‘Lysosomal accumulation and subsequent cell- Dept. of Psychiatry and delivered a lecture, ‘What were we thinking: to-cell pathology progression in Alzheimer’s disease’, 26 August 2015. A new psycho-educational program for couples and their first babies Prof. Mitchell G Weiss, Professor Emeritus, Swiss Tropical and to prevent postpartum common mental disorders’, 31 October 2015. Public Health Institute, Switzerland, visited the Dept. of Mental Health Education 26-28 August 2015. Dr. Helen Herrman, Professor of Psychiatry, the Centre for Youth Mental Health, The University of Melbourne, Australia, visited the Dr. Sanjay Pai, Columbia Asia Hospital, Bangalore, visited the Dept. Dept. of Psychiatry and delivered a lecture, ‘Improving mental health of Neurovirology and delivered lectures, ‘How to write a paper’ and and resilience in perinatal mental health’, 31 October 2015. ‘How to deliver a lecture’, 28 August 2015. Shri. Jayakar Jerome, former Indian Ambassador to Republic of Dr. Patricia Torres, University of San Luis Potosí, Mexico, visited Slovenia, former commissioner of Bangalore Development Authority the Dept. of Psychiatry and delivered a lecture, ‘Possible research (BDA), visited NIMHANS and delivered a public lecture, 6 collaboration on adolescent risk behaviors’, 9 September 2015. November 2015.
Prof. Tom Solomon, University of Liverpool, U.K and team of faculty visited NIMHANS, 20 September 2015.
Dr. Martin Webber, Director, International Centre for Mental Health Social Research, Department of Social Policy and Social Work, University of York, UK visited Psychiatric Rehabilitation Services unit and the Dept. of Psychiatric Social Work and delivered a lecture, ‘Mind the Gap: Developing Social Interventions to Fill the Global Mental Health Treatment Gap’, 21 September 2015.
Prof. Dinesh Bhugra, President, World Psychiatric Association & Visiting Professor, NIMHANS, Bangalore, visited the Dept. of Psychiatry and delivered a lecture, ‘How Indian psychiatrists can Shri. Jayakar Jerome, former Indian Ambassador to Republic of Slovenia, former commissioner of Bangalore Development Authority (BDA) contribute to the World Psychiatric Association (WPA) Action Plan?’, 22 September 2015. Dr. Veeranna, Scientist, Nathan S. Kline Institute for Psychiatric Research (NKI), New York, USA, visited the Dept. of Neurophysiology Dr. Helen Sharp, Reader in Clinical Psychology, Institute of and delivered a lecture, ‘Neurofilament Phosphorylation and Their Psychology Health and Society, Liverpool University, UK, visited the Role at the Synapse: Implications for Psychiatric Disorders’, 9 Dept. of Biostatistics, 1 October 2015. November 2015.
Dr. Kristina Hofberg, Consultant Perinatal Psychiatrist, Brockington Dr. David Austin, Associate Professor, Faculty of Health, Deakin MBU, Stafford, UK, visited the Dept. of Psychiatry and NIMHANS University, Australia, visited the Dept. of Clinical Psychology and Centre of Well-Being (NCWB), and delivered a lecture, ‘Psychodrama delivered a lecture, ‘eHealth Platforms and its Implications for Psychotherapy’, 8-20 October 2015. Prevention of Health Problems’, 17 November 2015.
46 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Prof. Malavika Kapur, Indian Institute of Advanced Studies, Bengaluru Dr. David Austin, Associate Professor, Faculty of Health, Deakin University, Australia Dr. Vinod D Deshmukh, Neurologist, Florida, USA visited the Dept. of Psychiatry and NIMHANS Integrated Centre for Yoga, and also Dr. Rex Haigh, Consultant Medical Psychotherapist, Royal took part in the symposium, ‘Integrating Scientific and Contemplative College of Psychiatrists, and Anando Chatterji, CEO, Therapeutic Approaches to Explore the Mind’, 6 December 2015. Community Psychotherapist, Hank Nunn Institute, visited the Psychiatric Rehabilitation Services unit and took part in the deliberation on Therapeutic Community Concept, 24 November 2015.
Dr. Carsten Bonnemann, Professor of Neurology, and Director of the Neuro Muscular Unit, NIH, USA, visited the Dept. of Neurology and delivered a lecture, ‘The Congenital Myopathies in the Age of Next Generation Genetics: The Impact So Far’, 27 November 2015.
Dr. Vinod D Deshmukh, Neurologist, Florida, USA
Dr. Narendranath V, Chief Administrative Officer, MS Ramaiah Medical Teaching Hospital, visited the Dept. of Epidemiology and delivered a lecture, ‘Management Techniques’, Bengaluru, 8 December 2015.
Ms. Bharthi, Clinical Psychologist, Sydney Hospital, visited the Dept. of Clinical Psychology, 10 December 2015.
Dr. Sankar Mitra, Professor and Full Member, Department of Radiation Oncology, Houston Methodist Research Institute, Houston, Texas, USA, visited the Dept. of Neurochemistry and Dr. Carsten Bonnemann, Professor of Neurology, and Director of the Neuro Dept. of Neurophysiology, and delivered a lecture, ‘Implications Muscular Unit, NIH, USA of genome damage and repair in diseases ranging from cancer to neurodegeneration’, 11 December 2015. Prof. Malavika Kapur, Indian Institute of Advanced Studies, Bengaluru, visited the Dept. of Psychiatry and delivered a lecture, Justice Gururajan, Chairperson, Fee Regulatory Committee, ‘Being a humane doctor: What are the qualities required of a health Karnataka Examinations Authority, visited NIMHANS, 15 professional?’, 30 November 2015. December 2015.
National Institute of Mental Health and Neuro Sciences 47 Annual Report 2015-2016
Prof. Edward V Quadros, Research Professor, SUNY –Downstate Dr. Eleanor Brindle, NFHS-4, USA, and Dr. Anil Mishra, NFHS-4, Medical Centre, New York, USA, visited the Dept. of Child and USA, visited the Dept. of Neurovirology, 12 January 2016. Adolescent Psychiatry and delivered a lecture, ‘Folate Receptor Autoimmune Disorder: Implications in the diagnosis and treatment Dr. Dana Gross, Professor of Psychology, St Olaf College, USA, and of autism’, 15 December 2015. team, visited the NCWB and Psychiatric Rehabilitation Services unit, 18 January 2016. Dr. David J Titus, Research Scientist, Department of Neurosurgery, University of Miami, Miller School of Medicine, Florida, USA, visited Dr. Priya Handa, Senior Scientist, Organ Care Research Program, the Dept. of Neurophysiology and delivered a lecture, ‘Therapeutic Swedish Medical Center, Seattle, WA, USA, visited the Dept. of Strategies to improve Cognitive Functions after Traumatic Brain Neurochemistry and delivered a lecture, ‘Iron overload, obesity and Injury’, 17 December 2015. NASH (nonalcoholic steatohepatitis): A dangerous nexus’, 19 January 2016. Dr. S Sinha, Advisor Medical Biotechnology Division, Department of Biotechnology, visited the Dept. of Neurovirology, 18 December Dr. John Cottrell, Psychiatrist, Sydney, Australia, visited the Dept. of 2015. Psychiatry and NIMHANS Integrated Centre for Yoga, 22 January 2016 Prof. Sunil Pandya, Consultant Neuro-Surgeon, Jaslok Hospital and Research Centre, Mumbai, visited the Dept. of Psychiatry and Dr. Suresh Kumar Balasubramanian, Associate Professor, School delivered a lecture, ‘The life and work of Major- General S.L. Bhatia’, of Biological Sciences, Faculty of Science, Monash University, 21 December 2015. Melbourne, Australia, visited the Dept. of Neurochemistry and delivered a talk, ‘Planting ideas for medicine: Translation genetics for Friedreich’s ataxia’, 23 January 2016.
Prof. Srikanth, Professor, Dr. Amit Prakash, Assistant Professor, International Institute of Information Technology, Bengaluru, visited the Dept. of Epidemiology and delivered a talk, ‘Health Management Information Systems’ 29 January 2016.
Prof. John Cox, University of Gloucestershire; and Institute of Psychiatry, London, UK, visited the Dept. of Psychiatry and delivered a lecture, ‘Use of Edinburgh Perinatal Depression Rating Scale Prof. Sunil Pandya, Consultant Neuro-Surgeon, Jaslok Hospital and Research (EPDS) in different settings’, 2 February 2016. Centre, Mumbai Dr. Rajappa S Kenchappa, Scientist and Assistant Professor, Depts. of Dr. Sat Bir S Khalsa, Assistant Professor of Medicine, Harvard Neuro-Oncology and Oncological Sciences, Moffitt Cancer Centre Medical School, USA visited the Dept. of Psychiatry and NIMHANS and Research Institute, USF- College of Medicine, Tampa, FL, Integrated Centre for Yoga, and delivered a talk, ‘Psychophysiology of USA, visited the Dept. of Neurochemistry and delivered a lecture Yoga Practice’, 7 January 2016. on ‘Myxoma Oncolytic Viral Therapy for Malignant Gliomas’, 10 February 2016.
Mr. Gopalkrishnan S, Co-founder, Infosys and Chairman, Axilor Ventures, Bengaluru visited the Psychiatric Rehabilitation Services unit, 15 February 2016.
Dr. Avdesh Sharma, Consultant, Parivartan Center for Mental Health, RAHAT Charitable and Medical Research Trust, New Delhi, visited the Dept. of Mental Health Education, 23 February 2016.
Mr. Amrith Bakhshy, President, Schizophrenia Awareness Association, visited the Psychiatric Rehabilitation Services unit, 4 Dr. Sat Bir S Khalsa, Assistant Professor of Medicine, Harvard Medical School, USA March 2016.
48 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Dr. Zul Merali, President/CEO, Royal’s Institute of Mental Health Dr. Alex Hankey, Distinguished Professor of Yoga and Physical Research (IMHR), University of Ottawa, Canada, visited the Science, SVYASA University, Swamy Vivekananda Yoga Anusandhana Psychiatric Rehabilitation Services unit, March 2016. Samsthana, Bengaluru, visited the Dept. of Neurophysiology and delivered a lecture, ‘The Mystery of Self-Awareness: A Possible Dr. Matcheri S Keshavan, Stanley Cobb Professor of Psychiatry, Solution’, 22 March 2016. Harvard Medical School, Boston visited the Dept. of Psychiatry and delivered a lecture, ‘Etiology and pathophysiology of schizophrenia: Prof. David A Bennett, Professor of Neurological Sciences, and Latest updates’, 7 March 2016. Director of the Rush Alzheimer’s Disease Center, Chicago, visited the Dept. of Neurology and delivered a lecture, ‘Biological Architecture of Prof. Eve Johnstone, Prof. Andrew Stanfield, Prof. David Owens and Age-Related Cognitive Decline’, 23 March 2016. Prof. Peter Kind, Division of Psychiatry, University of Edinburgh, UK, visited the Dept. of Psychiatry and Dept. of Child and Adolescent Psychiatry. Prof. Eve Johnstone delivered a lecture, ‘Forty years of research in schizophrenia’, 10 March 2016.
Prof. David A Bennett, Professor of Neurological Sciences, and Director of the Rush Alzheimer’s Disease Center, Chicago
Dr. Vinod Chaugule, National Health Trust (NHS), United Kingdom (UK), visited the Psychiatric Rehabilitation Services unit, 23 March Prof. Eve Johnstone, University of Edinburgh, UK. 2016. Dr. Mohan Isaac, Professor of Psychiatry (Population Mental Health) The University of Western Australia, Perth, visited the Psychiatric Dr. Karthik Sharma, Neurointensivist, Virginia University, USA, Rehabilitation Services unit and delivered a lecture, ‘Psychiatric visited the Dept. of Neuroanaesthesia, 28-31 March 2016. Rehabilitation-Indian and Australian Perspective’, 11 March 2016. Mr. Aashu Calapa, Director, The Live Love Laugh Foundation, Dr. Alan C Jackson, Professor of Neurology, University of Manitoba Bengaluru, visited the Dept. of Mental Health Education, 29 March Canada, visited the Dept. of Neuropathology, 14 March 2016. 2016.
National Institute of Mental Health and Neuro Sciences 49 K. Manjunath Patient Care Activities
Registraons 25000
20000
15000
10000 Screening 5000 140000
0 120000 10-11 11-12 12-1313-14 14-15 15-16 100000 PSYCHIATRY CHILD PSYCHIATRY NEUROLOGY NEUROSURGERY 80000 60000 40000 20000 0 10-11 11-12 12-1313-14 14-15 15-16
Emergencies (Casualty) 25000
20000
15000
10000 Admissions 5000 7000 6000 0 10-11 11-12 12-1313-14 14-15 15-16 5000 PSYCHIATRY CHILD PSYCHIATRY 4000 NEUROLOGY NEUROSURGERY 3000 2000 1000 0 10-11 11-12 12-1313-14 14-15 15-16 PSYCHIATRY CHILD PSYCHIATRY NEUROLOGY NEUROSURGERY
National Institute of Mental Health and Neuro Sciences 51 Annual Report 2015-2016
Discharges 7000 6000 5000 4000 3000 2000 Follow-ups 140000 1000 120000 0 10-11 11-12 12-13 13-14 14-15 15-16 100000 PSYCHIATRY CHILD PSYCHIATRY 80000 NEUROLOGY NEUROSURGERY 60000 40000 20000 0 10-11 11-12 12-13 13-14 14-15 15-16 PSYCHIATRY CHILD PSYCHIATRY NEUROLOGY NEUROSURGERY
Deaths 800 700 600 500 400 300 200 Extension Services 100 14000 0 12000 10-11 11-12 12-13 13-14 14-15 15-16 10000 PSYCHIATRY CHILD PSYCHIATRY 8000 NEUROLOGY NEUROSURGERY 6000 4000 2000 0 10-1111-12 12-1313-14 14-1515-16 GUNJUR GOWRIBIDANUR MADDUR KANAKAPURA MADHUGIRI SAKALAWARA TURUVEKERE
52 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
I. Mental Health Services B. Diagnostic Services
Psychiatry No. of patients / Facilities provided cases A. Clinical Services 2014-15 2015-16 Toxicology services (Centre for Addiction Medicine) 6203 18462 No. of patients / HPTLC-based tests Facilities provided cases GC-MS-based tests 2014-15 2015-16 Cassette-based tests General Adult Psychiatry Services Screening 113135 117478 C. Specialty Services Registrations 14016 16428 Emergency Services 7445 11031 Follow-ups 102439 119769 I. Centre for Addiction Medicine (CAM) Admissions 5565 5292 Extension Services The Centre for Addiction Medicine (CAM) continued to provide Sakalawara 9398 5694 comprehensive inpatient programme consisting of individual Gunjur 2394 2158 and family assessments. Individually tailored treatments involved Gowribidanur 5772 6135 Maddur 2740 2848 pharmacological interventions for withdrawal and long-term Kanakapura 2456 3341 prevention of relapse, individual and group counseling, family Madhugiri 2175 3486 counseling and intensive aftercare. Centre for Addiction Medicine New cases 3215 3183 Drug-Toxicology Laboratory: During 2015-16, the state-of-the- Follow-ups 12257 13717 Admissions 1070 1215 art laboratory tested around 18,000 samples for drugs like cannabis, Tele-consultations 8158 15561 cocaine, amphetamine and alcohol in urine and blood by using Gas Home visits 140 315 Chromatography and Mass Spectroscopy (GC MS) as well as Liquid Emergency - 1364 Chromatography method. The lab has been receiving requests from Electro-convulsive therapy (ECT) services: outside agencies for tests to be done, since it is the only facility for New cases 752 919 Total number of sessions 6636 7189 such testing in the region. Obsessive-Compulsive Disorder (OCD) Clinic: 394 495 Opioid Treatment Clinic: An exclusive Opioid Treatment Clinic has New cases 2061 1860 been started in the Centre for Addiction Medicine (CAM) complex Follow-ups to facilitate comprehensive treatment for the patients addicted to Schizophrenia and Metabolic Clinic different opioids. The buprenorphine maintenance treatment (BMT) Total cases 2373 2714 was provided to 100 patients during this period. Geriatric Clinic No. of elderly screened 3457 7110 No. of new cases 850 204 Community Outreach Services: Community social workers Perinatal Psychiatry Clinic: conducted addiction awareness and prevention programs in New registrations 104 238 Anganwadi centres, community (Bhovi Colony, BTM Layout, Follow-ups 672 799 Bengaluru), PHC’s, high schools/colleges, ITI, and workplaces Mother-Baby Unit inpatient admissions 74 58 (like BHEL, Bommasandra Industrial Area, etc.). They have been Telemedicine services: 957 818 successful in educating communities about addiction and setting up Family Psychiatry 381 700 prevention strategies for drug and alcohol related problems. Legal Aid 272 276 EPAC 254 376 Women Inpatient Facility: This exclusive 20-bed facility, opened NIMHANS Integrated Centre for Yoga 9729 14238 in 2014, offers specialized treatment to women with substance use (NICY) disorders. In 2015-16, a total of 92 patients received treatment in this Total 321341 367009 facility.
During 2015-16, the number of discharges stood at 5039 (compared Tobacco Cessation Centre (TCC): The multidisciplinary to 4872 in 2014-15) and deaths at 5 (as compared to 11 in 2014-15). TCC team conducted awareness programme on tobacco related
National Institute of Mental Health and Neuro Sciences 53 Annual Report 2015-2016 problems, behavioral counseling and treatment in collaboration Facilities/Services 2014-15 2015-16 with Central Board for Workers Education (CBWE), Ministry Number of elderly screened 3457 7110 of Labour & Employment, Government of India. A workshop on Number of new cases 646 850 Tobacco Use and Related Harm (Assessment, Brief Intervention Number of follow-up 2503 2454 and Pharmacological Management) was also organized at Number of admissions 256 250 Mathrusri Ramabai Ambedkar Dental College & Hospital by the team. The Geriatric Clinic and Services in association with Alzheimer’s and Related Disorders Society of India (ARDSI)—Bangalore Chapter Aftercare Services & Vocational Rehab: CAM has dedicated and Nightingales Medical Trust organized various programmes manpower for aftercare and vocational rehabilitation. During the to mark World Alzheimer’s Day 2015 based on the annual theme review period, 15561 telephone calls were made to the patients “Remember Me”. who were expected to come for follow-up and 315 home visits were conducted to facilitate effective treatment and enhance follow-up A ‘Reverse-Walk’ was organized on 20 September 2015 at the Freedom compliance of the patients. Unemployed patients who secured job Park in which over 500 people including senior citizens and caregivers placements were facilitated. Online automated software is being used participated. The event was flagged off by former test cricketers by the aftercare team to maintain the database and send reminders to Mr.Javagal Srinath and Mr.Venkatesh Prasad. Students of NIMHANS the patients about the follow-up. College of Nursing actively took part in the exhibition and other events held to raise awareness about Alzheimer’s and dementia. II. Family Psychiatry Centre IV. Obsessive Compulsive Disorder (OCD) Clinic The Family Psychiatry Centre offers both outpatient and inpatient family therapy services. The major services include family therapy, The OCD Clinic offers outpatient services every Tuesday from marital therapy, and family intervention for different psychiatric 9am to 1pm at the OPD block of NIMHANS. Severely ill and/or disorders. The centre conducts training programmes for trainees treatment resistant patients with OCD are routinely admitted to the from NIMHANS and other institutes across the country in wards for intensive pharmacological and psychosocial intervention. the field of psychiatry, psychology, psychiatry social work and The clinic actively collaborates with other departments/services nursing. Trainees from the Departments Clinical Psychology such as neuropsychology, molecular genetics, behavior therapy, and and Psychiatric Social Work and residents from the Department neuro imaging in research and clinical works. The clinic has a website of Psychiatry received training for three months and one month intended for public to know about OCD and services rendered at the respectively. Basic orientation course and advanced course in clinic (http://www.nimhans.kar.nic.in/ocdclinic/home.html). family therapy are also offered by the centre. During the year under review, faculty members associated with the centre were involved V. Electro Convulsive Therapy (ECT) Services in organising various programmes on family therapy in different parts of the country. Electroconvulsive Therapy (ECT) is one of the most effective treatment options for patients who are diagnosed with a range of III. Geriatric Clinic & Services mental illnesses. The procedures are conducted by the multidisciplinary ECT team including professionals from the Departments of Psychiatry, Geriatric Clinic and Services, run on Saturdays every week (barring Neuroanesthesia and Nursing. A dedicated ECT suite housed in the closed holidays), offer multidisciplinary care to the elderly, aged Psychiatry Open General Ward is made use of for this purpose. Apart 60 years and above. The elderly who register with the screening from the ECT facility, the suite has a pre-ECT preparation room, a outpatient service unit are screened by the Geriatric Psychiatry post ECT recovery room and a separate waiting hall for patients and Services team for various neuropsychiatric disorders. This process their attendants. Modified ECTs are administered with or without facilitates easier identification of mental health problems in the EEG monitoring. On an average, about 25 patients receive ECTs elderly—avoiding delay in referrals and enabling initiation of every day. Students from the departments of psychiatry and nursing appropriate intervention. are trained in all aspects of the ECT. Adult Psychiatry Units devote a complete day (the pre-OPD day) exclusively to carry out ECT The multidisciplinary group/team comprises psychiatrists, activities; wherein two-three junior residents are posted for the purpose neurologists, neuropsychologists, social workers, residents and under direct supervision of a dedicated senior resident. Apart from the trainees. On average, 12-15 new cases go through brief evaluation, clinical services, research is also actively pursued on various aspects of and 8-10 elderly are evaluated in detail—and about 20-30 follow-up ECT. During the period under review, 919 new patients were registered patients are seen— every week. for ECTs and a total of 7189 ECT sessions were conducted.
54 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
VI. Transcranial Magnetic Stimulation Laboratory and Services overarching goal of the InSTAR program to effect an “inclusive” transformation with an emphasis on “individualization” of treatment The state-of-the-art Transcranial Magnetic Stimulation (TMS) approaches in schizophrenia. laboratory has been carrying out a number of investigational and therapeutic trials of TMS. The TMS lab also provides clinical IX. Genetic Counselling and Testing (GCAT) Clinic services in the treatment of resistant neuropsychiatric disorders that include depression, OCD, tic disorder, auditory hallucinations in The purpose of this facility is to conduct evaluation for known schizophrenia, dissociative disorders, tinnitus, somatization disorders mutations in subjects clinically diagnosed as Huntington’s disease, and motor aphasia. The lab has two repetitive pulse delivery enabled spinocerebellar ataxia. Patients and relatives are counseled prior to systems, one of which can perform investigational paradigms to assess collecting the blood sample for diagnosis of Huntington’s disease and cortical motor physiology using paired pulse paradigms supported autosomal dominant disorders/conditions. GCAT team is involved by an electromyography system. An advanced MRI-guided neuro- in the pre-genetic counseling, genetic testing and post-genetic navigation system has also been acquired and is in use for both counseling of the patients whose neurological examination has been research and clinical applications. In 2015-16, a total of 864 TMS done by a neurologist and confirmed to show symptoms of the disease. sessions were delivered (407 as a part of the research application Pre- Genetic Counseling involves educating and counseling about and 457 as clinical). Among these, 510 sessions were delivered using the implications of the testing. Genetic testing undertaken in the lab neuro-navigation. MD psychiatry residents are trained in basic is accurate and reliable. Most people get a result which is definitely principles, therapeutic procedure, and selection of potential patients normal or definitely abnormal. However, a small number of people for treatment by appropriate screening procedures and monitoring of fall into a “grey area”, between the normal and the abnormal range. adverse effects during treatment. The TMS lab, in collaboration with Post-genetic counseling involves disclosure of results by the clinician other brain stimulation services like ECT and tDCS, organized the 1st keeping in mind the sensitive nature of the issue. Symposium on Non-invasive Brain Stimulation in Psychiatry on 20 September 2015, which drew about 200 participants. X. Emergency Psychiatry and Acute Care (EPAC) Services
VII. Transcranial Direct Current Stimulation (tDCS) Emergency Psychiatry and Acute Care (EPAC) services provide round-the-clock consultation and care for patients presenting with Transcranial Direct Current stimulation (tDCS) is a neuromodulatory psychiatric emergencies. technique that delivers low intensity, direct current to cortical areas facilitating or inhibiting spontaneous neuronal activity. tDCS has The EPAC team also manages specialized wards such as PRIORITY adaptive neuroplastic effects and it is a safe procedure. So far, tDCS (to manage patients with high risk to self and others in POGW for Lab at the Department of Psychiatry has completed more than males), SAFER (Safety and Facilitate Early Recovery) and ASIST 2300 sessions of tDCS administration safely without any significant (Applied Suicide Intervention, Support and Treatment). adverse effects. In the recent past, substantial background works on tDCS, supported by extramural research grants, have been taken The EPAC team has formulated several standard operating procedures up and several peer-reviewed research articles published. Ongoing for sexual assault victims, and designed new treatment chart and works at the lab has been incorporated in International Regulatory priority ward guidelines for staff and residents. Guidelines for tDCS. Increasingly, faculties from all specialty clinics (Schizophrenia, Obsessive Compulsive Disorder, Geriatric Psychiatry, The EPAC team in association with the NIMHANS Center for Well Center for Addiction Medicine, Perinatal Psychiatry Clinic and Mood Being (NCWB) has also been conducting the gate keeper training Disorders) are in the process of initiating clinical research studies in program for suicide prevention since 2013. More than 600 community- tDCS with an aim to integrate this with regular clinical practice. based gatekeepers from diverse backgrounds have been trained till date.
VIII. Schizophrenia Clinic & Metabolic Clinic XI. Community Psychiatry Services
The special clinical services of the Schizophrenia Clinic and the Community Psychiatry Services are delivered by a multidisciplinary Metabolic Clinic have been integrated to formulate a comprehensive team consisting of psychiatrists, psychiatric nursing, psychiatric social program – Individualized Schizophrenia Treatment and Reintegration work, clinical psychology, and vocational trainers. Outpatient services (InSTAR). The mission of InSTAR programme is to ensure a are extended to the population of surrounding catchment areas on a personalized clinical approach towards understanding and treating thrice-weekly basis (on Monday, Wednesday and Friday). The clinical individuals with schizophrenia and related psychoses. The acronym services focus predominantly on epilepsy, alcohol disorders and severe InSTAR (“instar”) also means a “stage of change” reflecting the mental disorders.
National Institute of Mental Health and Neuro Sciences 55 Annual Report 2015-2016
The Sakalawara Community Mental Health Centre (SCMHC) has Perinatal psychiatry services also focuses on training the postgraduate been the hub of all community mental health activities at NIMHANS. residents of psychiatry, psychology and psychiatric social work in Residential rehabilitation services are made available in 22 cottages for clinical assessment of perinatal psychiatric syndromes, pre-pregnancy short-term (~ 3 months) stay of persons with chronic mental illness. counselling for women with preexisting psychiatric illnesses and Such patients referred by adult psychiatry units of NIMHANS can post history of postpartum psychiatric illnesses, risk assessment for stay with their family members. Common group activities as well as infant harm and self-harm, mother infant bonding assessment and personalized activities — depending on the initial assessment and the interventions, use of psychotropic medication in perinatal period, nature of the patients — are conducted under supervision. In-house infant assessment. It conducts regular workshops and training activities for re-establishment of work habits for the chronically ill programs for doctors, nurses, mental health professionals, pediatricians include classes/training in craft, tailoring, computer skills, etc. at the and obstetrician to provide education and to increase the awareness Mahobodhi building of SCMHC. regarding perinatal psychiatry.
Telemedicine services for the benefit of inmates ofNirashritara First national conference on Motherhood and Mental Health was Parihara Kendra (erstwhile Beggars Colony, Magadi Road), held on 31 October 2015. A video-enabled training kit for health Bangalore are run thrice in a month (on Wednesdays). On an professionals working in the area of maternal mental health was average, 10 patients per session availed these services during 2014- released. Virtual Knowledge Network sessions for perinatal psychiatry 15. Extension clinics/camps were held at two primary health centres have been initiated. Sessions included assessment and management (in Gunjur and Nirashritara Parihara Kendra, Magadi Road) and of various mental health problems occurring during pregnancy and taluk hospitals at Kanakapura, Gouribidanur, Madhugiri, Maddur, postpartum period. Visit the website of perinatal psychiatry http:// and Anekal. www.perinatalpsynimhans.org/ for latest updates.
“Manochaitanya Super-Tuesday” programme was launched by the XIII. Molecular Genetics Laboratory Government of Karnataka to provide free treatment, counselling and medicines to people suffering from mental disabilities in rural to semi- Molecular Genetics Laboratory carries out research projects and urban areas. As part of this ambitious programme, extension services diagnostic work in neuropsychiatric conditions (schizophrenia, were in collaboration with primary care doctors posted rotationally to bipolar affective disorder, obsessive compulsive disorder, dementia, respective camps. Huntington’s disease, spino-cerebellar ataxia, Duchene’s/Beckers muscular dystrophy and spino-muscular atrophy). Till date, over The Community Psychiatry Team conducted 40 home visits for the 15000 DNA samples from neuropsychiatric conditions and 1050 benefit of dropped out patients to ensure adherence and compliance. control samples have been stored at the laboratory to facilitate research Schools (25) and industry (6) visits were also conducted to create with candidate-gene and epigenetic approach. awareness about mental health issues and find job placements of inmates of the residential centre. The protocols for leukocyte isolation from peripheral blood (PBMC), Epstein Barr virus supernatant generation and lymphoblastoid cell XII. Perinatal Psychiatry Services line establishment (LCLs) were established and samples processed appropriately. A total of 150 samples with various neuropsychiatric The Perinatal Psychiatric Services at NIMHANS is dedicated conditions (dementia, bipolar affective disorder, obsessive compulsive to helping the mother, the mother-infant dyad, husbands and disorder, Huntington’s disease and spino-cerebellar ataxia) were families who need treatment, support and guidance for any mental examined. health problem related to pregnancy or child birth. Perinatal service provides both inpatient and outpatient care to the mothers XIV Consultation Liaison Services and baby. Outpatient services include medication, psychotherapy, counselling and education, family counselling, marital counselling, The Consultation Liaison Psychiatry (CLP) services have seen and interventions for mother-infant bonding problems including increase in the referrals from critical care ICU and other departments video enabled interventions. Inpatient services of perinatal psychiatry including neurology, neurosurgery, etc. Outpatient services were also have Mother-Baby Ward with five beds and dedicated staff. Mothers provided by the CLP team, mainly by providing referrals to neurology needing inpatient care are admitted here along with her baby. Apart and neurosurgery departments. from usual treatment, specific focus is to facilitate mother-infant bonding and education on postpartum psychiatric disorders for The CLP services have grown beyond the campus, extending to mothers, spouses and family members. four outreach centres including palliative care in Kidwai Memorial
56 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Institute of Oncology, at SDS TRC & Rajiv Gandhi Institute of XVI. Free Legal Aid Services Chest Diseases, Bangalore, NGO-funded Jnana Sanjeevani Medical Centre (Diabetic and Endocrinology Clinics) and NIMHANS Free Legal Aid Clinic is held two days a week, on Tuesdays and Centre for Well Being. After 20 years, CLP has again collaborated Fridays (from 3.00pm to 5.00pm). The prime objective of the clinic— with Palliative Department of Kidwai Memorial Institute of established in 2011 under the Legal Services Authorities Act, 1987— Oncology, for providing a platform to meet psychological needs is to provide services such as legal advice, legal representation and of their patients and facilitate clinical learning and research legal adjudication free of cost as persons with mental illness are often opportunities. the weaker sections of the society and their human rights are many a time subject to violation. Patients availing treatment at the hospital In addition to routine pre and post-surgical psychiatric evaluations can utilize free legal aid services. Persons with disabilities can assert of patients undergoing epilepsy surgery, various new initiatives their rights using such clinics in matters such as disability certification, were taken up in collaboration with the departments of neurology, employment and pension. They can also defend their rights regarding neurosurgery and neuroradiology. The team was involved in admission to mental hospitals, human rights violation, treatment, various academic programs and workshops both within and outside property issues and marital issues. Women can also seek help in issues NIMHANS. such as sexual violence, domestic violence, property related issues, etc. Additionally, these kinds of services could help in making patients CLP team has successfully prepared various assessment forms to aware of their rights and equip them to avail the benefits of the meet the needs of the variety of patients across different specialties— different social welfare activities sponsored by the State and Central including forms for pre-surgical evaluation in epilepsy (surgery), Government. Though the majority of clients are persons with mental evaluating psychiatric morbidity in cancer, chest diseases and diabetes, illnesses, the clinic is providing services to patients with neurological and collusion interview questionnaire. In addition, the team is also as well as neurosurgical disorders. involved in the development of current health assessment scale for general hospital setting. Nimhans Centre for Well Being (Ncwb) XV. Telemedicine Services A. Clinical Services Telemedicine is the delivery of healthcare services, where distance is a critical factor, by all healthcare professionals using information No. of patients/ and communication technologies for the exchange of valid Facilities provided cases information for diagnosis, treatment and prevention of disease and 2014-15 2015-16 injuries, research and evaluation, and for the continuing education Telephonic Enquiries 1435 1280 of healthcare providers, all in the interests of advancing the health of individuals and their communities. The Telemedicine Network Total New Registrations 587 500 Project in Karnataka state was introduced with a hope to bridge Consultation Liaison Psychiatry 206 202 this gap and make specialist health-care reach populations in remote Marital Enrichment Services 51 33 underserved villages. Right Choice Clinic (CAM) 21 13 Aaraike and Child Parent Well Being 86 82 Telemedicine in Karnataka is currently a public sector initiative Stress Management and Lifestyle Clinic 72 36 with special focus on tele-consultation, where the district hospital Flourish Clinic (Positive Mental Health 31 28 doctors initiates the consultation from the tertiary hospital on Clinic) difficult cases for opinion on diagnosis and obtains the line of Psychology Care Clinic 44 49 management. There are 11 tertiary hospitals providing tele- Aasare (Parent Support group) 59 32 consultation service at present. The tertiary hospitals, after Trauma Recovery Clinic 27 15 receiving requests, review the history and investigations and gives suggestions for further management. NIMHANS is one such SHUT Clinic (Services for Healthy Use of 24 40 Technology) tertiary institute providing the telemedicine services to 26 district hospitals and two taluk hospitals of the Karnataka State. The tele- Awake 12 4 consultation is carried out on appointment basis and is free for the Window to Well Being 13 end-user (patient). Total 2655 2327
National Institute of Mental Health and Neuro Sciences 57 Annual Report 2015-2016
Child and Adolescent Psychiatry Marital enrichment therapy 35 57 CAM therapies - 166 A. Clinical Services Neuropsychological rehabilitation 81 67 (cognitive retraining), Neuropsychology No. of patients/ Unit Facilities provided cases EEG neurofeedback training 86 92 2014-15 2015-16 Neuropsychological rehabilitation at the - 36 Child and Adol. Psychiatry cases screened 7461 6959 Dept. of Neurorehabilitation New files registered 2561 3851 Music-based neuropsychological rehabili- - 4 tation at the Dept. of Neurorehabilitation Follow-up 18078 14580 Adult psychotherapy and counseling at of - 150 Admissions 639 590 cases at Psychiatric Rehabilitation Services Casualty & emergency 99 108 General hospital intake - 117 Total 28838 26088 General hospital therapy - 89 New Services SHUT clinic (service for healthy use of - 40 Clinical Psychology technology) Follow-up camps (Sakalawara Community 151 153 A. Clinical Services Mental Health Centre) Therapy at Sakalawara Community Mental 21 30 Health Centre –IP No. of patients/ Facilities provided cases Therapy at Sakalawara Community Mental 76 129 Health Centre –OP 2014-15 2015-16 Evaluation of cases in camps 30 17 Evaluation of adult cases 1571 1139 New cases, Stress and Lifestyle Clinic 72 32 Adult psychiatry follow-up cases 8361 6225 Follow-ups, Stress and Lifestyle Clinic 152 Evaluation of addiction cases 75 32 Psychological Care Clinic, NCWB - 49 Follow-up of addiction cases 410 486 Window to Wellbeing, NCWB - 13 Evaluation of child and adolescent 554 244 psychiatry cases Developmental Perinatal Services - 140 Evaluation of mentally-handicapped 368 100 Total 15613 14136 children and adolescents Evaluation of cases at Psychiatric - 198 B. Diagnostic Services Rehabilitation Services
Follow-ups at Psychiatric Rehabilitation - 40 No. of patients/ Services Facilities provided cases TBI-Cognitive Disability (evidence in the 7 12 2014-15 2015-16 Small Cause Courts) Psychological Assessment TBI-Cognitive Disability (evidence in the 0 1 High Court) CAM assessment - 45 Therapy / Intervention Assessment of intellectual functions of mentally challenged children and 335 472 Behavioural medicine intakes 871 860 adolescents Behavioural medicine therapy 396 415 Assessment of intellectual functions at 40 30 Counseling, remediation and therapy of 402 494 IMRC (JHMRC) child and adolescent psychiatry cases Psychological assessment of Child and 435 484 Developmental therapies - 140 Adolescent psychiatry Parental counseling (for parents of 218 135 Assessment at Adhar camp for mentally 63 70 children with intellectual disability/mental challenged children and adolescents retardation) Neuropsychological Assessments 1867 2115 Adult psychotherapy and counseling 1358 1665 Neuropsychological assessment, - 53 Family and marital therapy 470 417 Neurological Rehabilitation
58 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Assessment of intellectual functioning, - 3 Service for Healthy Use of Technology (SHUT) Clinic: NCWB Neurological rehabilitation through SHUT Clinic offers psychological intervention and Intellectual assessment of adult cases, - 20 other vital services for persons with problematic or addictive Psychiatric Rehabilitation Services use of information technologies (video game, internet browsing, Psychodiagnostic assessment of adult - 14 e-reading, social networking sites, pornography, etc.).The majority cases , Psychiatric Rehabilitation Services of the treatment seekers are in the age group/range 16-19 years. Neuropsychological assessment of adult - 4 During the year under review, 40 users sought consultation from cases, Psychiatric Rehabilitation Services the SHUT clinic for issues related to tech dependency and abuse. Social Skills Assessment Psychiatric - 19 Continuous efforts are being made to raise awareness about the Rehabilitation Services consequences of technology overuse and addiction through Neuropsychological assessment, - 4 informative articles in print/visual media. Caregiver issues are Psychiatric Rehabilitation Services handled through individual and group sessions held on last Sakalawara Community Mental Health 4 8 Saturday of every month. Centre -IP Sakalawara Community Mental Health 35 37 Structured Social Skills Training Sessions: Structured Social Skills Centre -OP Training Sessions have been initiated for day boarders and in-patient Camps 145 119 referrals in Psychiatric Rehabilitation Services (from September Sakalawara Community Mental Health 111 96 2015). The services are delivered either in group format or through Centre – Certificate issued for disability individual sessions depending on the client’s convenience and General hospital Assessment - 5 suitability. Assessments were done using the Social skills Assessment Total 3035 3598 Screening Scale developed by Psychiatric Rehabilitation Services. A total of 19 patients were provided with social skills training during the period September 2015- March 2016. C. Specialist Clinic Services Flourish Clinic: This one-to-one consultation service is run Community Mental Health Centre: Group therapy sessions tailored on a weekly basis on all Saturdays (except second Saturdays and to the needs of in-patients and their caregivers are held as part of holidays) by the Positive Psychology Unit at NCWB. It caters to the in-patient rehabilitation services at the Sakalawara Community the concerns of adults with felt needs for professional consultation Mental Health Centre. Social skills training in group format was for maintaining/ enhancing their wellbeing and functioning and provided to about 60 patients, through sessions conducted once a self-development. During 2015-16, a total of 32 new clients week. Approximately, 65 caregivers participated in the group therapy registered for receiving consultation services at the clinic. The sessions held once in two weeks, primarily focusing on areas such typical number of sessions per client in this year ranged between as caring for self, relaxation training, effective communication and 3 and 10. expressed emotion. Cognitive remediation in a group format has been introduced (from April 2015) and about 60 patients took in The Trauma Recovery Clinic: The consultants of the clinic (Dr. LN these sessions. ‘Cognitive Remediation/Enhancement Services’ for Suman and Dr. AS Veena) were inducted as members of a special individual patients have been started (from March 2016) and one unit at NIMHANS for specialized care for women subjected to patient has utilized this service so far. Dance and Movement Therapy domestic violence. The Ministry of Health, Government of Punjab, has also been introduced (from October 2015) and nearly 35 patients sought the services of the consultants of the clinic for designing a participated in these sessions, held twice a week. one-week training programme for counsellors to address trauma related to sexual assaults. Consultation was provided to NGO ‘IT Aasare: A parent’s support group, Aasare, at NIMHANS Centre for Change’ (ITfC) for a prevention programme on gender based for Well Being (NCWB) began its services in 2013 with an aim at violence in Karnataka, in collaboration with the Department of offering parenting skills and group based intervention for parents State Education, Research and Training (DSERT), Government of children with behavioral, emotional and learning difficulties. The of Karnataka. The consultants of the clinic were also approached services are run by the Department of Clinical Psychology in liaison for consultation by Swasti, an NGO, for initiating a sexual with the Department of Child and Adolescent Psychiatry. The clinic abuse prevention programme in academic settings in Bangalore. is operational on Saturdays (forenoon). The purpose is to facilitate Five workshops were conducted for counsellors by the clinic at interaction among parents to understand parental issues and give NCWB and IEC material on ‘Psychological Trauma’ was prepared suggestions. It follows a single session format. A total of 5 group for dissemination of information. A total of 15 clients sought sessions were held in which 22 parents were seen. consultation at the clinic during the year under review.
National Institute of Mental Health and Neuro Sciences 59 Annual Report 2015-2016
Stress Management and Lifestyle Clinic: This clinic, which was Psychiatric Social Work started in 2011, is run by the Behavioral Medicine Unit at NCWB and is operational on all Friday afternoons. It is aimed at offering A. Diagnostic Services stress management services to people from different walks of life as well as for those who require help in maintaining or achieving No. of patients/ healthier lifestyles. The services are being carried out by faculty Facilities provided cases members and PhD scholars of the Behavioural Medicine Unit, Dept. 2014-15 2015-16 of Clinical Psychology. Since last year MPhil Clinical Psychology Detailed work-up 4794 3639 trainees are posted to Stress Management and Lifestyle Clinic on rotation basis (as part of their behavioural medicine posting). A Follow-ups 10611 11599 series of workshops were conducted on academic stress, managing IP 2621 2603 interpersonal relationships, understanding social anxiety and work OP 289 260 stress for the urban community at the NCWB. Disability assessment 303 325 Group therapy 69 505 Window to Wellbeing: A special clinic for youth, Window to School mental Health 15 25 Wellbeing, was initiated a year ago at NCWB. It is run on second Individual & Family assessment 186 1244 and fourth Tuesdays, every month, between 2pm and 4pm. The clinic Screening 689 284 aims to address the developmental challenges faced by youth (16 to 24 years), which make them vulnerable to stress and psychological Home visits 12 30 difficulties. These include stress related to academics, relationships, Industrial visits 05 10 emotional problems (depression, anxiety, adjustment problems), Family get-together 12 59 self-esteem issues, self-harming behaviours, and suicidal thoughts Psychosocial services 397 402 or acts. The clinic also liaises with the parents to improve their Supportive therapy 20 10 communication and relationships with children, and bridge the Collateral contacts 31 692 generation gap. Counsellors and teachers working with youth on Day-out 04 24 psychological problems and building their skills were trained. Rehab counselling - 105
Developmental Intervention Services: These services have Agency visits - 23 been started as part of the weekly Perinatal Psychiatry Services NCWB activities - 56 to facilitate developmental assessments and related therapies. Total 20058 21895 The clinic receives four patients on average at the OP level. The facility provides early intervention to the infants of women with AWAKE Clinic: The clinic for women with intimate partner mental health problems, who are at high risk for developmental violence is held every second and fourth Wednesdays between 2.00 delay and behavioural problems. Similar services are also provided pm and 4.30 pm at NIMHANS Centre for Wellbeing (NCWB). to the infants admitted to mother-baby unit on need-to-serve The clinic offers various services such as: (a) tailor-made mental basis. During the year under review, services were provided to140 health intervention and counselling for women with intimate partner mother-infant dyads. violence/domestic violence (b) trauma care for the victims of violence (c) supportive therapy and individual therapy to build self-esteem, Psychological Care Clinic: This service is being provided at NCWB self-confidence, coping skills, problem solving and communication for clients experiencing stressors, difficulties in coping with day- skills (d) telephone counselling; providing referral services and to-day demands of their work or personal lives, emotional distress information regarding available resources, legal rights, shelter, care, and interpersonal difficulties. A detailed evaluation is carried out etc. (e) support group services to women survivors of intimate partner to determine the nature of the problems, particularly to identify if violence f ) community based awareness programme to prevent they require a psychiatric evaluation, in which case they are referred gender based violence. to the Psychiatric Out-Patient Services of NIMHANS. The other clients are offered one-to-one counseling and therapeutic services as The services are being carried out by faculty members and PhD required. Interventions are usually brief, ranging from 2 to 8 sessions. Scholars of the Department of Psychiatric Social Work. Follow-up services for these clients are also provided. The services are provided by consultants, clinical psychologists and research scholars Aaraike: The psychosocial care clinic for general public at NCWB from the Dept. of Clinical Psychology. offers: (a) Family Enrichment Programme to strengthen the
60 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 families to enhance quality of life (b) Pre-marital counseling for C. Magnetoencephalography (MEG) Procedures : couple to prepare them to take the responsibilities of marriage and family life, (c) Industrial Mental Health services for the employees No. of patients/ to deal with the occupational stress and promotion of positive Facilities provided cases mental health (d) Martial Enrichment Services for the couple to 2014-15 2015-16 enhance their marital quality and their wellbeing. The clinic is Epilepsy (Temporal & Extra - Temporal) 155 278 run by faculty members of the Departments of Psychiatric Social Absence & JME 36 6 Work and Clinical Psychology on every first and third Wednesdays between 2 pm and 4.30 pm. Wilson’s disease 41 13 Alzheimer’s disease 11 4 Control (test) 5 - II. Neurosciences Services Total 248 301
Neurology D. Specialist Clinic Services A. Clinical Services No. of patients / cases No. of patients/ Facilities provided Facilities provided cases 2014-15 2015-16 2014-15 2015-16 Neuro Muscular 797 960 Registrations 20101 18083 Epilepsy 576 480 Follow-ups 74906 75956 Movement Disorder 370 815 Admissions 4461 3913 Dementia (Geriatric OPD of Psychiatry) 1961 2914 Casualty (Emergency) 19460 20395 Stroke ward numbers 19 30 Telemedicine services 37 21 Total 3723 5199 Total 118965 118368 Neuromuscular Disorders Clinic: This is a multidisciplinary During 2015-16, the number of discharges stood at 3594 specialty clinic, conducted on fourth Saturdays of every month. About (compared to 3845 in 2014-15) and deaths at 248 (compared to 60-80 patients with various Neuromuscular disorders attended this 168 in 2014-15). clinic every month during the year under review. Genetic analysis for Duchenne Muscular Dystrophy and Spinal Muscular Atrophy with B. Diagnostic Services genetic counseling is also offered at the clinic.
No. of patients/ Movement Disorders Clinic: The clinic is held on the first and the Facilities provided cases third Saturdays of every month and approximately 25-40 patients were 2014-15 2015-16 seen in each OPD session. Hundreds were treated with Botulinum Digital Electroencephalography (EEG) 3926 4016 Toxin and DBS was also offered, during the period under review. Visual Evoked Potential (VEP) 1431 1286 Epilepsy Clinic: About 30-50 patients with refractory epilepsy were Brain Stem Auditory Evoked Response (BAER) 1349 1270 seen in the Epilepsy Clinic, held on first and third Saturday of every Somato Sensory Evoked Potential (SSEP) 1435 1254 month. Patient-centred treatment plans were developed and free Video EEG (VEEG) 515 602 drugs were distributed to deserving patients. Free legal aid services Polysomnography (PSG) 85 09 were also provided by the clinic. Research activities are also carried out Electroneuromyography (ENMG) 2350 1984 in the above clinics through various funded/non-funded projects and Electrocardiogram (ECG) 2077 2516 DM & PhD Clinical Neurosciences courses. Intra Operative Monitoring (Video EEG) 05 05 Stroke Ward: The Stroke Ward encompasses five ICUs, five step- Total 13173 12942 down and three special wards. Patients with arterial, venous stroke
National Institute of Mental Health and Neuro Sciences 61 Annual Report 2015-2016 are admitted and managed. Sizeable numbers of patients have been Functional Surgery DBS and 19 42 managed through thrombolysis, decompressive craniotomy and thalamotomy other procedures. A protocol for acute ischemic stroke thrombolysis Epilepsy Surgery 45 42 and venous stroke management has been prepared and is being MVD for trigeminal 41 21 utilized. Patient education related activities and training of neuralgia paramedical staff regarding triage of acute stroke is carried out on Endoscopic Surgery 117 149 a regular basis. Biopsy Stereotactic Biopsy 66 77 Brain Biopsy 12 7 Neurosurgery Shunt 697 506 Craniotomy for 191 134 A. Clinical Services stroke Spinal Degenerative 246 283 Disorder No. of patients/ Gamma Knife 242 272 cases Facilities provided Radiosurgery 2014-15 2015-16 Miscellaneous 1792 1761 Registrations 18032 19857 Total 7114 7163
Follow-ups 46687 45174
Admissions 6562 6530 euroanaesthesia Casualty (Emergency) 17539 18208 N Total 88820 89769 A. Clinical Services
During 2015-16, the number of discharges was 5749 (compared to No. of patients/ 5669 in 2014-15) and deaths 668 (compared to 510 in 2014-15). Facilities provided cases 2014-15 2015-16 Anaesthesia in Operation Theatres OT CENSUS a) Elective operations 1778 1789 Type of surgery No. of Cases 2014-15 2015-16 b) Emergency operations 3257 3490
Vascular Cranial 405 357 5035 5279 Spinal 3 2 Intensive Care Units Congenital Cranial 46 20 Medical ICU 108 106 anomalies CVJ 57 49 Surgical ICU 367 419 Emergency ICU 599 607 Spinal 46 17 Tumours Supratentorial 748 673 1074 1132 Infratentorial 333 294 Total 6109 6411
Spine 157 101 Infection 197 99 B. Diagnostic Services Trauma Cranial acute 1188 1836 CVJ 15 29 No. of patients/ Spinal 109 75 Facilities provided cases Peripheral Nerve Brachial Plexus 43 34 2014-15 2015-16 Surgery Injury Neuroradiological procedure done under 1886 2440 Entrapment 16 25 sedation/GA Neuropathy Modified ECT 6696 7189 Chronic Subdural 307 258 Hematoma Total 8512 9629
62 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
C. Specialist Clinic Services B. Diagnostic Services
Pain Clinic, which was started in 2014, conducts various procedures No. of patients/cases Service to treat patients with RSD, trigeminal neuralgia, post-dural puncture 2015-16 headache, etc. During the year under review, 17 cases of RFA for Speech Language Pathology 3675 trigeminal neuralgia were handled, 12 TFES injections for back and neck Audiology 1592 pains were adminsitered and five epidural blood patch procedures for two patients for refractory orthostatic headache (from SIH) were carried out. Follow-up 645 Total 5912
Neuro Imaging & Interventional C. Specialist Clinic Services Radiology Stuttering Group Therapy: The Department of Speech Pathology and Audiology continued to hold group therapy sessions on Saturdays A. Clinical Services for stutterers. Forty sessions were conducted in the reporting year with an average attendance of 5-8 persons per session. The group therapy No. of patients/ aimed at building confidence, enhancing interaction with other Facilities provided cases members of the group and adopting strategies for easy flow of speech. 2014-15 2015-16 These interactive sessions have helped persons with stuttering face the Neuro-interventions 145 151 communication challenges more effectively.
B. Diagnostic Services III. Rehabilitation Services No. of patients/ Facilities provided cases 2014-15 2015-16 Psychiatric Rehabilitation Services Routine X-ray examinations 26950 33604 Ultrasound examinations 3348 3600 The Psychiatric Rehabilitation Services (PRS) are provided by a Computed Tomography Scans 45665 56651 multidisciplinary team comprising faculty from the Departments of Magnetic Resonance Imaging 14021 15750 Psychiatry, Clinical Psychology, Psychiatric Social Work, Nursing; junior consultants; senior residents and post graduate students from Digital Subtraction Angiography 1298 1604 both within and outside the Institute. SPECT CT 68 16 MR-PET MR alone - 2033 PRS caters to rehabilitation needs of patients in various settings: MR PET - 32 Day-care, inpatient, outpatient and referrals from psychiatry inpatient units. PRS has various vocational sections including baking, Total 91350 113290 printing, computer, candle making, weaving, crafts, plastic-moulding, carpentry, horticulture, tailoring, leather, etc. Patients are trained in these vocations for varying periods of time and efforts Speech Pathology & Audiology A. Clinical Services A. Clinical Services
No. of patients/ No. of patients/cases Facilities provided cases Facilities provided 2015-16 2014-15 2015-16 Number of therapy sessions 2463 New day boarders enrolled 49 98 Number of patients who attended group 22 Day Boarders discharged 66 100 therapy sessions for stuttering In-patient referrals to PRS 1040 1318 Number of group therapy sessions 123 SERWICE patients consultations (out- 872 1249 Total 2608 patient services)
National Institute of Mental Health and Neuro Sciences 63 Annual Report 2015-2016
In-patient admissions specifically for 16 26 assistance. During the year under review, as part of the vocational rehabilitation purposes (unit 4b admission) placement by PRS team, 5 clients were placed at different agencies/ Psychotherapy 66 150 companies including Delhi Freight Couriers (1 as Data Operator), Star Bazaar (2 as Store Assistants), Sap Labs/ Enable India (1) and Special Initiative Social skill training - 19 Swachhata Agency (1). Eight persons received vocational counselling Total 2109 2960 and they got recruited at different places after attending interviews on their own. Details of referrals to PRS from 1st April 2015 to 31th March 2016
Field liaison visits to various government and non-profit organizations No. of patients/ for facilitating effective networking were conducted on first Thursday cases Facilities provided of every month. 2014-15 2015-16 New day boarder enrollment 49 98 Caregiver Education and Support Programmes Day boarder discharges 66 100 Out-patient services- Services for Enhanced 872 1249 No. of Date Theme Recovery with Intensive and Comprehen- Participants sive Engagement (SERWICE) Evaluation 16-05-2015 Handling The Stigma Of Person With 42 In-patient referrals to PRS 1040 1318 Mental Illness In-patient admissions specifically for 16 26 19-06-2015 Physical health issues in persons with 60 rehabilitation purposes mental illness Total 1977 2791 21-07-2015 Yoga for Better Health 45 19-08-2015 What After Me? 40 B. Diagnostic Services 15-09-2015 Handling Side effects of medications 72 for Mental Illness No. of patients/ 20-10-2015 Dignity in Mental Health 42 cases Facilities provided 17-11-2015 Managing Caregivers Mental Health 34 2014-15 2015-16 29-12-2015 Dealing with Alcohol and Tobacco 35 IQ/ Neuropsychological Assessments/ others 39 53 use 19-01-2016 Positive Aspects of Caregiving 34 Disability certificates: Disability certificates issued by various units 23-02-2016 Swavlamban Health Insurance 45 of Adult Psychiatry and the Department of Child and Adolescent Scheme Psychiatry are as follows: 15-03-2016 Managing Financial burden of 25 caregivers Type of certificates 2015-16 Total 474 Disability as per IDEAS 436 Intellectual disability certificates 680 Sanjeevani Vedike Programmes Total 1116
No of D. Specialist Clinic Services Date Theme Participants 27-04-2015 Management of MR Patients at Home 28 SERWICE: Services for Enhanced Recovery with Intensive and Comprehensive Engagement (SERWICE) caters to the rehabilitation 25-05-2015 Importance of Rehabilitation in 21 Mentally ill Persons needs of patients with severe mental disorders (schizophrenia, bipolar disorder, severe obsessive compulsive disorder) and mental retardation. 15-06-2015 Handling Difficult Situations 16 In the year 2015-16, a total of 20 cases were enrolled and 133 patients 20-07-2015 Marriage and Mental Illness 27 were followed up by MD/DPM residents under SERWICE. 17-08-2015 Communication with Patients 8 21-09-2015 Caregiver Burden and Coping with 12 Vocational Training: Various vocational rehabilitation programmes Mental Illness have been developed and implemented by PRS. The unit provides 19-10-2015 How to Engage with clients after 18 services such as counselling and guidance and job placement discharge at home
64 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
16-11-2015 Welfare Benefits for persons with 18 psychiatric disability 21-12-2015 Psychiatric Emergencies 6 18-01-2016 Family Support in Mental Illness 23 15-02-2016 Importance of Psychiatric 10 Rehabilitation Total 187
Engagement and recreational activities
No. of Activities Sessions Rangoli competition Domestic skills workshops 24 Recreational activities for patients and caregivers 47 Music and dance therapy sessions 51 Neurological Rehabilitation Art therapy sessions 78 Indoor games 6 A. Clinical Services Picnics for patients to Lalbagh Botanical Garden 2 Celebration of festivals and national days 5 1) Medical services Sales counters at workshops 2 Total 215 No. of patients / Consultations and ward-admissions in cases Dept. of Neuro-Rehabilitation As part of the World Mental Health Day celebrations, various indoor/ 2014-15 2015-16 outdoor games and competitions in music, rangoli, art, etc. were held Number of new referrals 9332 10122 on 4 November 2015 for patients and staff. Number of follow-ups 1447 1288 Number of admissions 228 217 Number of discharges 227 216 Number of health education sessions 70 70 conducted Classes for trainees 11 12 Neuro-muscular Clinic 419 420 Total 11734 12345
2) Para-medical services (Physiotherapy, Occupational Therapy and Orthotics) Art competition
Services provided by Occupational Therapy Total no. of patients Sessions 2014-15 2015-16 No. of new patients 3069 3354 Follow-up sessions 13514 16770 Treatments provided 54056 67080 ADL sessions 1714 2947 Treatment provided 3428 5894 No. of sessions 620 867 Cricket match for day-boarders
National Institute of Mental Health and Neuro Sciences 65 Annual Report 2015-2016
Neuro-muscular Clinic 519 492 orthotists) take care of rehabilitation needs of the patients with neuromuscular disorders. More than 400 patients benefitted from Robotic hand Rehabilitation 35 58 these services, during 2015-16. Total 76955 97462
aboratory ervices No. of patients/ IV. L S Services provided by orthotic section cases Appliances 2014-15 2015-16 Neurochemistry Total number of beneficiaries 175 207 Total no. of appliances made 352 394 Diagnostic Services Number of repairs and follow-ups done 12 09 No. of follow-up 03 11 Blood, urine and CSF investigations No. of patient from NR ward - 156 No of patient from OPD - 43 Parameters 2014-15 2015-16 No of patient from ICU & other wards - 8 Albumin, Serum 41741 45573 No of patient benefited under CMMRF and - 72 Alkaline Phosphatase (ALP),Serum 42820 45936 RAN scheme Ammonia, Plasma 4281 5460 Total 542 900 Angiotensin Converting Enzyme (ACE), 673 724 Serum Psychiatric Social work Anti-thrombin, Plasma 56 142 Anti-cardiolipin Antibodies-IgA, Screening, 15 90 1. Detailed assessments: 172 cases Serum 2. Follow up sessions: 516 Anti-cardiolipin Antibodies-IgG, Screening, 30 139 3. Wheelchair referral: 92 Serum 4. BPL and Income reassessments: 72 Anti-cardiolipin Antibodies-IgM, Screening, 31 120 5. Caregivers support group: 26 Serum 6. Family recreation activity: 16 Antiphospholipid Antibodies IgG, 664 303 Screening, Serum Antiphospholipid Antibodies IgM, B. Diagnostic Services 651 301 Screening, Serum
No. of patients/ aPTT 7024 9061 Facilities provided cases Aryl Sulfatase A , Serum 322 292 2014-15 2015-16 Abnormal metabolites Screening , Urine 2151 2588 Urodynamic Study 64 110 Bence Jones protein Screening, Urine 535 451 No. of educational material: Clean 10 46 Bilirubin Total, Serum 43071 46327 Intermittent Catheterization (CIC Brochure) given to the patients Calcium, Serum 5536 5277 No. of Clean Intermittent Catheterization 10 46 Carbamazepine (CBZ), Serum 266 387 (CIC) taught to the patients Ceruloplasmin, Serum 589 708 Total 84 202 Cholesterol Total, Serum 8754 10275 Copper 24 hours, Urine 278 316 C. Specialist Clinic Services Copper, Serum 661 709 Creatine Kinase (CK),Serum 4265 4132 The Department of Neurological Rehabilitation is running Creatinine, Serum 55642 60446 Neuromuscular Clinic in association with the Department of Neurology on fourth Saturday, every month in the main OPD CSF Glucose 6296 6760 building. A team consisting of consultants, resident doctors and CSF Lactate 1488 1720 paramedical staff (physiotherapists and occupational therapists/ CSF Protein 6303 6840
66 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Electrolytes - Serum, Urine (Na/K/Cl),CSF Neuromicrobiology 70291 76872 (Cl) Fibrinogen, Plasma 54 15 Folate, Serum 2639 5024 Diagnostic Services Gamma Glutamyl Transferase(GGT), Serum 2534 2827 No. of patients/cases Glucose, Serum 55339 61017 Facilities provided 2014-15 2015-16 HbA1c (Glycated Haemoglobin) 2296 3591 CSF cell count 6439 6483 Hexosaminidase Total A & B, Serum 335 267 CSF cytology 953 2077 High Density Lipoprotein (HDL) Cholesterol, 8740 10238 Serum CSF cultures 3463 3262 Homocysteine, Serum 3860 5001 Pus cultures 120 161 Homocystinuria Screening, Urine 45 56 Routine cultures 7230 8272 Lactate Dehydrogenase (LDH), Serum 987 555 Fungal cultures 2977 3232 Lactate, Plasma 3766 4626 AFB cultures 2433 3558 Lithium, Serum 4725 5174 Serum ASLO determinations 356 97 Lupus Anticoagulant (LA) Screening, Serum 7 - CRP determinations 169 246 Micro-albumin, Urine 17 23 Serum Widal test 408 543 MPS Spot Test, Urine 25 24 Serum rheumatic factor test 2906 2984 Myoglobinuria Qualitative, Urine 48 37 Blood VDRL 3859 3743 Osmolality ,Urine 2919 3563 CSF VDRL 2925 2809 Osmolality, Serum 3019 3924 CSF – antimycobacterial antibody test by 2679 2303 ELISA (MTSE) Phenobarbitone (PB), Serum 44 74 CSF - mycobacterial immune complex of 2679 2303 Phenytoin, Serum 262 595 IgG type Phosphorus Inorganic, Serum 2599 2441 CSF – mycobacterial immune complex of 2679 2303 Porphobilinogen Qualitative, Urine 282 317 IgM type Protein 24 Hours, Urine 27 27 CSF - anticysticercal antibody using 2679 2303 Protein-C, Plasma 73 169 Antigen-B Protein-S, Plasma 73 173 India ink for Cryptococci 2854 3060 Prothrombin Time (PT) 8282 10605 Mantoux test 157 127 Screening for IEM by Tandem Mass Serum antinuclear antibody test 2892 2983 4602 5400 Spectrometry(TMS) CSF latex agglutination test for 326 181 SGOT (AST), Serum 43000 46007 Cryptococcal antigen SGPT (ALT), Serum 42998 46001 Serum/CSF Toxoplasma test by latex 88 34 agglutination T3 (Triiodothyronine), Serum 9361 11965 Koch’s spine 18 24 T4 (Thyroxin), Serum 9338 11877 Blood cultures 143 * Total protein, Serum 41771 45348 Oligoclonal band and monoclonal Triglycerides, Serum 8733 10249 gammopathy: 546 375 TSH (Thyroid Stimulating Hormone), Serum 9954 12704 IgG 546 375 IgA 546 375 Urea, Serum 55239 60030 IgM Uric Acid, Serum 1114 1571 Anti-acetylcholine receptor antibodies: 205 237 Urobilinogen Qualitative, Urine 24 49 Direct Valproate, Serum 910 1417 Vitek-2 Compact-60 1004 4268 Vitamin B 12, Serum 6553 9539 BACTEC MGIT 269 346 Total 641028 714776 BACT ALERT 956 1064
National Institute of Mental Health and Neuro Sciences 67 Annual Report 2015-2016
Electron Microscopy Investigations – Hospital Infections Surveillance System Blood bank sterility check - NIMHANS 516 840 No. of cases Facilities provided CSSD sterility check 30 26 2014-15 2015-16 610 608 OT sterility 26 65 Ultrastructural studies Water analysis 51 50 NIMHANS REFERRAL NIMHANS REFERRAL Diagnostic Electron 229 145 178 68 Screening of other sites: Throat, Axilla, Groin 314 104 Microscopy MRSA screening 1861 1086 Research 141 69 135 87 Red Cross Blood bag sterility 884 660 Total 60421 63817 Summary of tests done
Section Number Histopathology 8120 Neuropathology Electron microscopy 608 A. Clinical Services Total 8728
Autopsies 2014-2015 2015-2016 Neurovirology Clinical autopsies 26 20 Medico legal autopsies 368 370 Diagnostic Services Total 394 390
No. of patients/ B. Diagnostic Services Facilities provided cases 2014-15 2015-16 2015-2016 TOTAL Laboratory diagnosis of: Diagnostic Work Japanese Encephalitis 292 308 NIMHANS REFERRALS 2014-15 2015-16 Dengue 982 243 No. of Biopsies 3011 5109 7712 8120 Chikungunya 582 243 Rabies 302 304 Neurosurgical 2101 2683 4171 4784 Measles 278 289 Neurology 905 2428 3376 3333 Herpes encephalitis 468 498 Stereotactic Biopsy 30 7 28 37 Enterovirus 51 19 H1N1 2820 802 Muscle 577 861 1565 1438 HIV 4194 4008 Nerve 146 1344 1450 1490 CD4 17666 16408 Early infantile diagnosis (EID) 1951 2031 Skin 136 112 225 248 HIV viral load 165 1411 Liver - 6 7 06 Hepatitis B 1292 1489 Brain biopsy 26 44 81 70 FNAC 03 - - 03 Lip Biopsy 08 - - 08 Neurophysiology Artery - 15 - 15 Diagnostic Services Muscle - Enzyme 577 427 - 1004 Histochemistry No. of patients/ Immunohistochemistry 1216* 1855* - 3071* cases for Tumour Diagnosis (3762)# (6544)# (10306)# Facilities provided 2014-15 2015-16 Muscle 206* 96* - 302* Immunohistochemistry (1146)# (485)# (1631)# Autonomic Function Test 983 1241 Total 8942 15376 18616 23929 Pulmonary Function Test 257 355 [* - total number of cases, #- total number of tests] Total 1240 1596
68 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Transfusion Medicine & Haematology Research Project 215 91 Prothrombin Time - 4779 A. Diagnostic Services Activated Partial Thromboplastin Time - 4779 Protein S - 47 Therapeutic plasma exchanges: 2398 large volume and 214 small volumes procedures were done for patients suffering from various Protein C - 48 neurological diseases, and 81 therapeutic phlebotomies were Antithrombin III - 27 performed for patients suffering from Polycythemia. Total 71780 83993
B. Diagnostic Services V. Supportive Services
Transfusion Medicine Centre Nursing
No. of patients/ A. Clinical Services Facilities provided services 2014-15 2015-16 No. of patients/ ABO grouping and Rh typing 47361 56557 Facilities provided cases Haemoglobin estimation done for blood donors 7714 7938 2014-15 2015-16 Blood donation (Donors) 6886 7297 Acute nursing care given 11033 10563 Blood and blood components collected 13977 18390 Intensive Nursing Care given 11225 10781 Blood Donation Camps attended 66 81 ECTs given 6705 5243 Blood and blood components issued 13390 17621 Emergency Nursing care given Blood and blood components issued to 4431 6738 Neurology 28733 29888 other Hospitals Neurosurgery 26337 26961 Psychiatry 10333 12215 Phlebotomies done for the Patients 108 81 Chronic patient care 19720 19619 Small volume Plasmapheresis 318 214 No. of surgeries assisted 5096 5324 Large volume Plasmapheresis 1890 2398 Community Mental Health Total 96141 117315 Services provided at Sakalawara Centre New cases (OP) 305 411 Clinical Pathology Old cases (OP) 4898 3283 Inpatients 51 No. of samples Home visits 24 27 Facilities provided 2014-15 2015-16 Extension Clinics (New & Old cases) 16595 16320 Complete Blood Count 46963 51746 Total 141004 140686 Urine Examination 4050 4922 Peripheral Smear 9027 10030 B. Diagnostic Services Peripheral Smear for MP 378 599 ESR 10693 9709 No. of patients/ cases Absolute Eosinophil Count 66 186 Facilities provided 2014-15 2015-16 Absolute Neutrophil Count 67 171 Samples sent to different laboratories for Reticulocyte Count 55 62 various investigations from the following: Sickling Test 97 133 Neuro Center Wards 119225 107027 Bone Marrow Study 12 14 Psychiatric wards including 133614 163298 Saline Dilution Test 61 200 Casualty and Emergency Services Stool Examination 96 97 Total 252839 270325
National Institute of Mental Health and Neuro Sciences 69 Annual Report 2015-2016
C. Specialist Clinic Services New Follow-Ups Admissions Discharges Death Emergencies
Others 3923 4447 283 289 00 00
Number of picnics arranged for inpatients: 13 Domestic skills workshops: 18 SPECIAL CLINICS (OPDs) & SERVICES Sanjeevini Vedike program: 12 Caregivers Support program: 10 1. A special clinic is held on fourth Saturday of every month in association with the Department of Neurology. Ayurvedic medications are provided and improvements in health conditions of patients are assessed through regular follow-ups. During the reporting year, 1115 patients with neuro-muscular disorders (muscular dystrophy patients) were treated at the OPD level.
NEW OLD DISEASE/ TOTAL Adult Child Total Adult Child Total DISORDER M F MC FC M F M F MC FC M F M F
Becker muscular Distribution of clothes to patients on the occasion of Ugadi festival by Friends dystrophy of NIMHANS Trust (organized by the Dept. of Nursing, NIMHANS) (BMD) 12 0 0 0 12 0 25 0 2 0 27 0 39 0 Duchenne muscular In-service Education Programme: dystrophy (DMD) 17 5 100 5 117 10 61 16 314 15 375 31 492 41
In order to equip the newly joined staff nurses with the necessary Limb-girdle muscular skills for providing efficient patient care by following all standard dystrophy procedures, an In-service Education Programme (ISEP) was (LGMD) 18 14 6 5 24 19 49 39 8 16 57 55 81 74 conducted in three batches, with a total of 51 hours of teaching. Motor neurone Faculty members from the Dept. of Nursing, as well as other disease (MND) 2 0 0 0 2 0 20 2 0 2 20 4 22 4 Departments at NIMHANS (viz. Neuro Anesthesia, Neuro Spinal Microbiology, Interventional Radiology, Neuro Virology, and muscular Transfusion Medicine) were involved in the teaching programme. A atrophy (SMA) 4 2 5 0 9 2 12 1 13 3 25 4 34 6 pre-post evaluation showed that there was a significant improvement Other in knowledge scores of the staff, following the ISEP. disorders (unspecified) 77 26 50 3 127 29 78 45 38 5 116 50 243 79
Total 130 47 161 13 291 60 245 103 375 41 620 144 911 204 VI. Ayush Services
2. A special Geriatric OPD services are run by the Department, yurveda A every Tuesdays. The data of patients who attended the Geriatric OPD during the reporting year is as follows: HOSPITAL SERVICES
Outpatient services are offered on a regular basis at the main OPD Number of Patients Attended block of NIMHANS. Patients with various neurological and New Old Grand Total psychiatric disorders are provided with specialized consultations and Male Female Male Female Male Female treatment. Number of patients treated during the reporting period at OPD and IPD are as follows: 318 193 615 366 933 559
70 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
NIMHANS VII. Other Services Integrated Centre for Yoga (NICY) Human Genetics NIMHANS Integrated Centre for Yoga (NICY) was established in July 2014 to facilitate services, training and research activities A. Clinical Services related to yoga in mental health and neurosciences. The centre has a multidisciplinary working group of faculty members from 13 No. of patients/ departments, who are interested in yoga and allied activities. Facilities provided cases 2014-15 2015-16 During 2015-16 a total of 14238 patients and caregivers availed yoga services. Separate sessions were held for patients with different neuro- Genetic counselling 34 42 psychiatric disorders and caregivers by expert yoga therapists using validated yoga modules. B. Diagnostic Services Facilities provided 2014-15 2015-16 Patients/ caregivers who availed services 9729 14238 No. of patients/ Facilities provided cases New registrations 1270 1671 2014-15 2015-16 Sessions held 2128 2936 Karyotyping 12 8
Training programmes: C. Specialist Clinic Services
Apart from the regular services, NICY conducted four Yoga The Department of Human Genetics provides genetic counselling Appreciation Courses, each spanning one-month, for the staff and services (online and in person) for patients and their family members students of NIMHANS from April 2015-March 2016. More than 60 with various genetic, psychiatric and neurological disorders. persons participated in the courses and received appropriate training in yoga. The Centre has also developed a video CD containing yoga During the year under review, counselling services were extended modules for patients with schizophrenia and depressive disorders. to patients with sporadic and familial brain and nervous system The videos are being used in the sessions conducted at the centre tumors, and families with congenital malformation syndromes as well as at homes of the patients. Similar video tools are being like Down syndrome and other trisomies. Genetic counselling was developed for other disorders. The centre has also received requests also provided to families with balanced translocations as well as for training/ internship from different countries. In 2015-16, two for subjects seeking premarital counselling. A total of 42 patients psychologists from France and Germany were trained in Yoga for and their family members benefited from the genetic counselling mental disorders. services.
IEC activities: Karyotype data of two families, suffering from familial mental retardation for two generations, were examined. Based on the During 2015-16, four editions of the quarterly newsletter, Samatvam, information gathered, the individuals from these families were advised were brought out by NICY. The newsletters received wide appreciation on their reproductive choices. from the target audience. The staff and faculty of the centre delivered more than 10 invited lectures at various conferences/ seminars. e-Samatvam, an e-newsletter ( June 2015 edition) complementing Mental Health Education the print edition was released in collaboration with the White Swan Foundation on their online portal. Various information brochures on Digital Display: A customizable digital display system has been yoga and mental health were also brought out. installed at the OPD and Casualty. This system is programmed for specific content needs of the clients through a computer connected A number of distinguished guests from various parts of India and to LAN (Local Area Network) and real time data such as hospital abroad visited the centre during the review period. statistics, inpatient strength, availability of beds, laboratory charges,
National Institute of Mental Health and Neuro Sciences 71 Annual Report 2015-2016 etc. are displayed. Display contents at various outpatient waiting halls project “Outcome of a School Based Health Education Program are customized to the requirement of the patients and caretakers. for Epilepsy Awareness among Teachers and School Children” by Dr. KS Meena, Assistant Professor, Department of Mental Health Education and Teaching /Training Materials: Educational/ Health Education, NIMHANS. A video titled “Mathina Maddhu” informational brochures for people with various mental and portraying positive communication and interaction patterns in a neurological disorders were developed in collaboration with the other family where one of its member is mentally ill was developed (in departments of the Institute including Psychiatry, Neurosurgery, association with Departments of Nursing and Psychiatry) in the Nursing, Psychiatric Social Work, and Clinical Psychology. context of World Mental Health Day for the patients and their primary caregivers at NIMHANS. A set of posters on suicide prevention and tobacco use was also developed for World No Tobacco Day. These posters are being used A documentary/video titled “Nannu Thambaku Bitte”, showcasing by the faculty and students of various departments to educate the the harmful use of tobacco among youth and how they can quit, public and community about the above specified topics. was made in collaboration with Centre for Addiction Medicine and Department of Nursing, NIMHANS. Photographic and Video Services: Photographic and video requests continued to show an upward trend. During the year under review, A set of eight videos was produced for Perinatal Psychiatry Services a total of 28542 digital images were taken of the 656 requests. as part of the video-assisted psycho-education module on “Maternal Psychiatry topped with 3108 digital images from 57 requests, followed and Infant Mental Health”. This was used during the National by Neurology 3030 images from 159 requests, and Neurosurgery Conference on Motherhood and Mental Health. A set of seven 2044 images from 128 requests. A total 5118 digital images of videos of all the scientific sessions of “Integrating Scientific and vital functions and administration/documentation programmes of Contemplative Approached to Explore the Mind” was made for the the institute were taken. Digital images of all the important events Department of Psychiatry (NIMHANS Integrated Centre for Yoga) and functions were selected and provided for documentation and and Garden of Samadhi as a prelude to H.H. Dalai Lama’s visit on presented during the Institute Day. Expenditure on printing of colour 7 December, 2015 photographs has been greatly reduced with the shift from analogue to digital photography. However, 300 photographs were printed for Posters, Brochures, Graphics & Illustrations documentation purpose. The variety and quantum of tasks and services in graphic design has Digital Images Numbers increased tremendously. The artists have honed their skills and have undertaken the production of increasingly complex products. Documentation 20328
Training images 3998 Particulars Numbers Clinical 4216 Graphics 744
Total 28542 Posters 27
Brochures 4 Video Numbers Images for manuals 361 Clinical Cases 265 Certificates, captions and nameplates 409 Training 51 Cover page /CD cover designs 2 Documentation 44 Lamination of posters 166 Total 360 Education materials issued 664
Training Videos: A training video on “First Aid for Epilepsy in Total 2377 Children” was developed as a part of the NIMHANS-funded
72 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Video clips for Digital Signage:
1. Awareness on Alzheimer’s Disease – College of Nursing 6. Dignity in Mental Health– Department of Mental Health 2. Extension Clinics- Department of Psychiatry Education 3. Geriatric services- Department of Psychiatry and Mental 7. Passive smoking– Department of Mental Health Education Health Education English 8. Special Clinics– Department of Psychiatry 4. Geriatric services- Department of Psychiatry and Mental 9. Services at Sakalawara Community Mental Health Centre- Health Education Kannada Department of Psychiatry 5. World No Tobacco Day 2015 – Department of Mental Health Education
Art therapeutic activity in Psychiatric Rehabilitation Services, NIMHANS, Bengaluru
National Institute of Mental Health and Neuro Sciences 73
Human Resource Development
A. Postdoctoral Fellows Ms.Elizabeth Joseph T Kerala Ms.Faseela Jaleel Kerala Ms.R Shobitha Shanthakumari Tamil Nadu 1. Dr. Rani Jancy AR, Child & Adolescent Psychiatry Ms.Upasana Baruah Assam 2. Dr. S Swathik, Acute Care and Emergency Psychiatry 3. Dr. Bharath Holla, Addiction Medicine Psychiatry: 2 4. Dr. Abhinav Nahar, Consultation Liaison Psychiatry Dr. Geetha Desai Karnataka 5. Dr. Saranya D, Geriatric Psychiatry Dr. Shivakumar V Karnataka 6. Dr. Aditya Hegde, Obsessive Compulsive Disorder & Related Disorders Neurology: 1 7. Dr. Deepali Garg, Neuroanaesthesia Dr. Ketaki Swapnil Bhalsing Maharashtra 8. Dr. Shekar Babu, Neuroanaesthesia 9. Dr. Deepti BS, Neurocritical Care Speech Pathology & Audiology: 1 10. Dr. Sarasa Kumar Sahoo, Neurocritical Care Ms. SS Meera Karnataka 11. Dr. Nadeem, Neurocritical Care 12. Dr. Kirtilaxmi Benachinmardi, Neuroinfections 13 Dr. H Sankaranarayanan, Neurological Rehabilitation II. DM (Neurology): 7 Dr. Kulkarni Advait Prakash Maharashtra 14. Dr. Sukanya Baruah, Transfusion Medicine Dr. Manjunath M Karnataka 15. Dr. Rajalakshmi P, Neuropathology Dr. Nitish Kamble Karnataka 16. Dr. Shilpa Rao, Neuropathology Dr. Raghavendra K Karnataka Dr. Rakesh Kumar Uttar Pradesh B. Qualifications Awarded Dr. Shantanu Shubham Bihar Dr. Suresh Kumar Korada Andhra Pradesh I. PhD III. DM (Child & Adolescent Psychiatry): 1 Clinical Psychology: 3 Dr. Sowmya Bhaskaran TS Tamil Nadu Ms. Divya Sadana Haryana Mr. Jereesh K Elias Kerala IV. DM (Neuroanaesthesia): 3 Ms. Megha Rupa Karnataka Dr. Mohit Mittal Punjab Dr. Shweta S Naik Karnataka Human Genetics: 1 Dr. Tanmay Ashok Jadhav Maharashtra Mr. Sibin MK Kerala V. MCh (Neurosurgery): 6 Neurophysiology: 2 Dr. Arunkumar S Pondicherry Ms. Anu Mary Varghese Kerala Dr. Borde Tushar Deepak Maharashtra Dr. Arun Kerala Dr. Chirag N Solanki Gujarat Dr. Nagarjun MN Karnataka Neuromicrobiology: 1 Dr. Pragyan Sarma Assam Ms. Jyothi EK Kerala Dr. Satyakam Baruah Assam
Nursing: 1 VI. MD (Psychiatry): 20 Ms. R Sumathi Karnataka Dr. Abhilash Balakrishnan Kerala Dr. Arun Vijay Gadad Karnataka Psychiatric Social Work: 6 Dr. Dhruva Ithal Karnataka Mr. Anvar Sadath V Kerala Dr. Guru S Karnataka Mr.Birudu Raju Andhra Pradesh Dr. Kiran BR Karnataka
National Institute of Mental Health and Neuro Sciences 75 Annual Report 2015-2016
Dr. M Lakshmi Prabha Tamil Nadu Ms. Preethi Anne Ninan Karnataka Dr. Nithin Ambekar Karnataka Ms. Priyanka Mittal Uttar Pradesh Dr. Rakshathi B Karnataka Ms. Radhika K Kerala Dr. Ramesh Jagarapu Andhra Pradesh Ms. Saima Saleem Uttar Pradesh Dr. Sathish Kumar SV Karnataka Ms. Shahanaz Aboobacker Ahmed Kerala Dr. Shere Siddhesh Sanjeev Maharashtra Ms. Shalini Mathew Karnataka Dr. Shilpa VS Kerala Dr. SK Altaf Hossien West Bengal XI. MPhil (Psychiatric Social Work): 15 Dr. Sowmyashree CN Karnataka Ms. Baseema K Kerala Dr. Sridatta Rajur Karnataka Ms. Dhanya P Kerala Dr. Suhas G Karnataka Mr. Fahim Ul Hassan Jammu & Kashmir Dr. Sutar Roshan Fakirchand Maharashtra Ms. Joice Steffi Y Karnataka Dr. Vinay Saini Haryana Mr. Nithyananda S Karnataka Dr. Virupakshappa Irappa Bagewadi Karnataka Ms. Reshma Karnataka Dr. Rajesh Suryabhan Dhakne Maharashtra Ms. Rupa Sanadi Karnataka Ms. Sabana Aboobaker Kerala VII. MPH: 4 Ms. Shari Tess Mathew Kerala Dr. Jagadeesh M Karnataka Ms. Shari M Kerala Dr. Kumar M V Karnataka Ms. Sherin Yohannan Kerala Dr. Smita Rawat Madhya Pradesh Ms. Suhara RH Kerala Dr. Vasanth Kumar DE Karnataka Ms. Tecie Lalduhzuali Mizoram Ms. Vidya Karnataka VIII. DIPLOMA (Psychiatry): 8 Ms. Yachna Pradhan West Bengal Dr. Chaitra VHM Karnataka Dr. Chetan Kumar KS Karnataka XII. Fellowship (Psychiatric Rehabilitation): 2 Dr. Manasa S Seshadri Karnataka Mr. Ashfak Ahamed PC Kerala Dr. Nithin Kondapuram Andhra Pradesh Dr. Chethan B Karnataka Dr. Pavithra N Karnataka Dr. Pramod HL Karnataka XIII. Fellowship (Psychosocial Support in Disaster Dr. Shweta Umakant Biradar Karnataka Management): 1 Dr. Umesh Karnataka Ms. Paramita Bhowmick West Bengal
IX. MPhil (Neurophysiology): 2 XIX. MSc (Psychiatric Nursing): 7 Ms. Kala P Nair Kerala Ms. Amrita Kuriakose Kerala Dr. UD Kumaresan Tamil Nadu Ms. D Lavanya Tamil Nadu Ms. Rebecca K Tamil Nadu X. MPhil (Neurosciences): 3 Ms. Rituparna Samanta West Bengal Mr. Arvind R Karnataka Ms. Sheeba Sara Daniel Kerala Ms. Chetna Sharma Madhya Pradesh Ms. Usha SN Karnataka Ms. Safoora Naaz Maharashtra Ms. Arpitha Elizabeth Jolly New Delhi
XI. MPhil (Clinical Psychology): 16 C. Degrees Awarded (In-Person) Ms. Aakriti Malik New Delhi nd Ms. Aswathy Das Kerala at the 2 Graduation Day Ms. Atulya Gurha New Delhi Ms. Cassandra Shruti Sundaraja Tamil Nadu I. BSc (Nursing): 61 Ms. Haleemunnissa S Karnataka Ms. Akhila Augustin Kerala Mr. Harishankar Vasudevan Moosath Kerala Ms. Akhila Prasad Kerala Ms. Kangkana Bhuyan Uttarakhand Ms. Aleena George Kerala Ms. Meenakshi Banerjee New Delhi Ms. Aleenamol Joy Kerala Ms. Mridul Kataria New Delhi Ms. Anjana Anilkumar Kerala Ms. Nisha C Tamil Nadu Ms. Anju Antony Kerala
76 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Ms. Anju Johny Kerala Ms. Spandana Yadav Uttar Pradesh Ms. Anju M Joseph Kerala Ms. Tintu Mathai Kerala Ms. Ashly Clara Cyriac Kerala Ms.Twinkle Shaji Kerala Ms. Ashly Tomy Kerala Ms. Anu Mol Stephen Kerala II. BSc (Radiography): 8 Mr. Bharath S Karnataka Mr. Abdul Basith.P. Kerala Ms. Chinchu Varghese Kerala Ms. Amitha Raj S Kerala Ms. Chinju Baby Kerala Ms. Amrutha Issac Kerala Ms. Chippy Kuriakose Kerala Mr. Jamsheer M Kerala Ms. Chippy Thankachan Kerala Ms. Nayana Murali Kerala Ms. Chippy Tomy Kerala Mr. Subhra Prakash Mallick West Bengal Ms. Dalphiya Jose Kerala Mr. Vinod T Thomas Kerala Ms. Dayana PK Kerala Mr. Mahesh S Uppar Karnataka Ms. Delna George Kerala Ms. Devika Raj Kerala III. BSc (Anaesthesia Technology): 4 Ms. Dhanya Mol.A.S. Kerala Ms. Anusha Subakumar Andhra Pradesh Ms. Dona P Kuriakose Kerala Ms. Lourembam Keeranbala Devi Manipur Ms. Ebenezer Sweetlin.R. Tamil Nadu Mr. Nune Vidheya Tamil Nadu Ms. Fincy M.Sunny Kerala Ms. Shilpa Johnson Kerala Ms. Greeshma Saji Kerala Ms. Jerin Jacob Kerala Ms. Jimcy George Kerala D. Qualifications Awarded Ms. Jithu George Kerala Th Ms. Linda Eldhose Kerala In-Absentia at the 20 Convocation Ms. Lintu Mathew Kerala Ms. Lisma Paul Kerala I. Post-Doctoral Fellows Ms. Maria James Kerala 1. Dr. Lekhansh Shukla, Addiction Medicine Ms. Maria Sunny Kerala 2. Dr. Gaurav Singh, Community Mental Health Ms. Mathu Dayanandan Kerala 3. Dr. Sonia Shenoy, (Clinical Neuro Sciences & Therapeutics in Ms. Meenu Maria James Kerala Schizophrenia) Ms. Merin Joy Kerala Ms. Merlien Anna Kurien Kerala II. Fellowship (Psychosocial Support in Disaster Ms. TT Milly Mizoram Management) Ms. Namitha Sebastian Kerala Mr. Palash Mandal Ms. Nebi Mole Kerala Ms. Nikitha Robin Karnataka III. PhD Ms. Nimishamol Joseph Kerala Ms. Nivya George Kerala Clinical Psychology: 1 Ms. M.Panjima Tamil Nadu Ms. Reji Mohan Kerala Ms. Pavithra.K. Karnataka Ms. Penini Syhly Mizoram Neurophysiology: 1 Ms. Prinu Jose Kerala Ms. Shilpa BM Karnataka Ms. Priyanka Prasad Rajasthan Ms. D.Raveena Tamil Nadu Psychiatric Social Work: 1 Ms. Reshma Baby Kerala Mr. Dharma Reddy Pashapu Andhra Pradesh Ms. Sheena Thomas Kerala Ms. Shimi Thomas Kerala Neurosurgery: 1 Ms. M.Showmi Tamil Nadu Dr. Ashok M Karnataka Ms. Sinu Thomas Kerala Ms. Sneha.C. Kerala IV. DM (Child & Adolescent Psychiatry): 2 Ms. Snehamol James Kerala Dr. Preeti K Tamil Nadu Ms. Sony Benny Kerala Dr. Raghu Nandan Mani Punjab
National Institute of Mental Health and Neuro Sciences 77 Annual Report 2015-2016
V. DM (Neurology): 3 II. Post-Basic Diploma (Neuro Science Nursing): 2 Dr. Devaraddi Navalli Karnataka Lt .Col. Sandhya S Kerala Dr. Pooja M Karnataka Lt. Col. Sartaj Sharma Andhra Pradesh Dr. Vinod Varghese Kerala III. Diploma in Clinical Neurophysiology VI. DM (Neuroanaesthesia): 1 Technology (DCNT): 6 Dr. Sritam Swarup Jena Odisha Mr. Bibin George Kerala Mr. Joby Jose Kerala VII. DM (Neuroimaging & Interventional Radiology): 1 Mr. N Livingston Tamil Nadu Dr. Subhendu Parida Odisha Ms. E Muthu Rajeshwari Tamil Nadu Mr. VR Prabhu Das Andhra Pradesh VIII. MCh (Neurosurgery): 1 Mr. Sagadevan M Tamil Nadu Dr. (Lt.Col.) Subir Dey New Delhi Ph.D Candidates under External Fellowships on 31.03.2016 IX. MD (Psychiatry): 2 WELL- DST-In- OTH- TO- Department CSIR UGC ICMR DST COME Dr. Swati Netam Madhya Pradesh spire ERS TAL Dr. Vishal V Karnataka GRANT Basic Sciences X. DIPLOMA (Psychiatry): 1 Biophysics 1 - - - 1 - 3 5 Biostatistics - - 1 - - - 4 5 Dr. Sandeep A Karnataka Human Ge- - 3 - - 1 - 2 6 netics XI. MPhil (Biophysics): 1 Neurochem- 3 2 - 1 - - 4 10 Ms. K Thangameenakshi Tamil Nadu istry Neuromicrobi- 2 6 - - - - - 8 XII. MPhil (Neurosciences): 1 ology Dr. Purba Basu West Bengal Neurophysi- 2 7 1 - - - 3 13 ology Neurovirology 1 - - - - - 1 2 XIII. MPhil (Clinical Psychology): 1 Psychopharma- - - 1 - 1 - - 2 Ms. Apoorva B Kerala cology Behavioural Sciences XIX. MPhil (Psychiatric Social Work): 1 Clinical Psychol- - 8 9 - - - 2 19 Ms. Monisha L Tamil Nadu ogy Psychiatric - 11 1 - - - 7 19 XX. MSc (PSYCHIATRIC NURSING): 2 Social Work Ms. Alphy Thomas Kerala Psychiatry 1 - 2 - - 3 15 21 Ms. Keerthini J Karnataka Neuro Sciences Neurology ------1 1 Clinical Neuro- -- 19 ---- 19 E. Qualifications Awarded at the sciences Neuropathol- 1 1 1 - - - 2 5 Institute Day Celebrations ogy Total 11 38 35 01 03 3 44 135 I. Post-Basic Diploma (Psychiatric/ Mental Health Nursing): 8 2011 2012 2013 2014 2015 Total Capt. Aparna NR Kerala CSIR 03 03 03 - 01 10 Ms. Ashadevi Shrirang Davare Maharashtra UGC 04 06 08 13 07 38 Ms. Mallika TK Kerala ICMR 06 08 09 06 06 35 Ms. P. Sindhu Lekha Kerala DST - 01 - - - 01 Mrs. Shobhana Surendra Palav Maharashtra DST-Inspire 01 01 01 - - 03 Maj. Susan Skariah Kerala WELLCOME GRANT - - 01 01 01 03 Ms. Vibhavari Vilas Jadhav Maharashtra OTHERS 05 08 12 08 06 39 Ms. P. Vishalakshmi Karnataka Total 19 27 34 28 21 129
78 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
F. Other Training Centre for Addiction Medicine (CAM)
I. Courses offered at NIMHANS The treatment gap for mental disorders is large in our country. To bridge this gap, Virtual Knowledge Network (VKN) NIMHANS— part of the Centre for Addiction Medicine (CAM) —in collaboration Sl. Number of Candidates Name of the Course with The Project ECHO is running weekly online NIMHANS- No. Passed Ongoing ECHO sessions. The heart of the NIMHANS ECHO model is its 1. Neuroanaesthesia hub-and-spoke knowledge-sharing networks, led by expert teams BSc (Anaesthesia technology) - 13 who use multi-point videoconferencing facilities to conduct virtual BSc (Anaesthesia technology) - 4 clinics with community health care providers (doctors and others). In internship this way, doctors, nurses, and other clinicians learn to provide excellent 2. NIIR specialty care to patients in their own communities. BSc Radiography 7 36 Radiography Trainee Course 12 - The ongoing weekly VKN NIMHANS ECHO telehealth session, 3. Neurology encompasses components of case based learning i.e. case presentation Diploma in Clinical Neurophysiology - 9 and Didactic sessions by experts. The aim of this weekly training Technology (DCNT) is to develop a learning loop and a knowledge-sharing network to 4. Nursing create in-depth knowledge, skills and self-efficacy among healthcare Diploma in Psychiatric Nursing (DPN) 8 10 practitioners. This guided practice helps in the process of reducing Diploma in Neuro Nursing (DNN) 2 2 disparity in the standard of treatment in the country. The partner College of Nursing health professionals also present cases for discussions and learning. BSc Nursing 61 (Passed 297 The live (synchronous) sessions are integrated with an e-learning in July 2015) module certification for participants. 5. Psychiatry Diploma (Psychiatry) 2014-16 - 9
II. Other training and capacity building programmes
Neuropathology
During the period 2015-16, a total of 659 students and consultants/ professionals from NIMHANS and outside Institutions obtained training in Neuropathology.
Transfusion Medicine & Haematology VKN session in progress
Students pursuing BSc courses in Nursing and Anesthesia at So far, over 900 healthcare professionals from medical colleges and NIMHANS were imparted training in Hematology and Clinical other health centres have partnered with this free-of-cost knowledge Pathology. A total of 18 students from NIMHANS and other institutes sharing platform. About 15 classrooms are made available for this attended training programme in Blood Component Separation, purpose and 50 individual health professionals participate in these Plasmaphereses and Blood Banking at Transfusion Medicine Centre. weekly, videoconference-based, sessions. In the year under review, A 10-day Induction Training Programme on Blood Storage Center, 600 participated in this programme and 300 received certificates upon sponsored by National Health Mission (NHM), was organised for successful completion of the training module. For details, visit http:// medical officers and lab technicians in separate batches. Induction vlc.nimhans.ac.in/ Training Programme The multidisciplinary team from Tobacco Cessation Centre (TCC) A series of Induction Training Programmes, sponsored by National organized three-day training programme for state and district Aids Control Organization (NACO), were conducted in association officers of National Tobacco Control Programme, Assam and dental with Karnataka State Aids Prevention Society (KSAPS) for medical professionals from Bangalore Institute of Dental Science. The team officers, nursing staff and lab technicians in batches throughout the also conducted an awareness programme on tobacco cessation for period under review. employees of Jindal Power Plant, Bellary.
National Institute of Mental Health and Neuro Sciences 79 Annual Report 2015-2016
As in previous years, post-graduate trainees from the departments of DM 2 Psychiatry, Clinical Psychology, Psychiatric Social Work, and Nursing DPM 1 received hands-on training in the management of persons with DM (Child & Adolescent Psychiatry) 2 addiction. MCh (Neurosurgery) 1 PDF (Child & Adolescent Psychiatry) 3 PDF (Neurological Rehabilitation) 2 III. Training for Students from Other Institutions at PhD (Computer Science) 1 NIMHANS MTech (Integrated MTech Program in 2 Cognitive Neuroscience) Sl. Number of MPhil 12 Stream Total No. Candidates MPhil (Clinical Psychology) 14 A. INTERNATIONAL MPhil/ PhD (Diploma in Clinical 23 Clinical Psychology 28 Psychology) Master’s Degree MSc (Electronics) 2 (1) Nina Dittmer, Rosenheim, 1 MA (Psychology) 2 Germany BNSY 3 (2) Ms. Jessica Notermans, University 1 MSc 3 of Psychology & Neurosciences, Internal (MSc Nursing/ DPM/MD/DM/ MCh) 7 University of Maastricht Certificate Course in CBT 5 (3) Marion Wellington, Brown 1 Asst. Professor in Psychiatry 1 University One-month certificate course, Positive 6 (4) Psychology Unit, Faculty of Arts, 25 Psychology Perspective: Research, Maldives National University, Education and Communication for Maldives Health (P3REACH) BTech (Mathematics) 1 Short Visit 127 Sl. Number of Name of the Stream Total MA 33 No. Candidates I Year 90 NATIONAL ECE 4 01. Biophysics 6 05. Epidemiology 9 PhD 1 MD (Community Medicine) 8 BE (Biotechnology) 3 MPH 1 MSc (Regenerative Medicine) 1 06. Human Genetics 143 MSc (Biological Sciences) 1 MD/ MS 1 02. Biostatistics 2 MBBS 1 MSc (Biostatistics) 2 MSc/PhD 38 03. Child & Adolescent Psychiatry 149 BSc/BTech 103 MD (Psychiatry) 108 07. Neuroanasthesia 150 MD (Pediatrics) 9 MD/MS 136 DM (Neurology) 2 BSc 8 DNB (Psychiatry) 10 PhD 6 DNB (Pediatrics) 1 08. Neurochemistry 11 DPM (Psychiatry) 08 MD/MS 1 DCH 4 PhD 1 PSW 5 MSc 4 PhD 2 BS-MS 1 04. Clinical Psychology 290 BE (Biotechnology) 3 External MD/DPM/DM/MBBS/MS 163 B Pharma 1 MD 65 09. Neuro Imaging & Interventional 159 MD(Community Medicine) 1 Radiology DNB 1 MD/ DNB/ Diploma / MCh / DM 159 DM (Neurology) 3 Neurology
80 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
10. Neurological Rehabilitation 6 17. Nursing 866 MD/MS 2 MSc (Nursing) 419 DM 2 PC BSc (Nursing) 118 BSc/ BPT/ BOT 2 (BOT)- Oc- Basic BSc (Nursing) 204 cupational BSc (Nursing) 75 therapy DPN 9 11. Neurology 341 Post Basic Diploma (Nursing) 41 MD 340 College of Nursing 135 MSc 1 MSc (Nursing) students 34 12. Neuromicrobiology 20 MD (Pediatrics) 1 BSc (Nursing) students 48 MD (Microbiology) 1 Post. Basic (Nursing) students 15 MSc (Microbiology) 11 GNM (interns) 38 BE (Biotech/MTech) 7 18. Psychiatry 555 13. Neuropathology 659 MD (Psychiatry) 230 MD (Dental) 6 DM 35 DM/M.Ch/MD/MS (Pathology, DPM 20 Microbiology, Neurology, Neurosurgery, 239 DNB (Psychiatry) 5 Radiology, Psychiatry & various other MBBS 36 disciplines) Internship 229 MPhil/PhD (Clinical Psychology) 23 Psychiatric Rehabilitation 970 MPhil/PhD Scholars-(various disciplines) 48 MD/MS (Psychiatry, Ayurveda, 15 MSc (Life Sciences). 1 Community medicine) BSc (Biotechnology) 2 MSc (Nursing) Externals 432 Bachelors of Physiotherapy (2 batches) 21 BSc External (Nursing) 349 Bachelors/Masters in Home Sciences (2 38 batches) Post Basic BSc (Nursing)- Externals 80 Bachelors of Ayurveda Medical Sciences GNM 38 9 (Interns) DPN Externals 14 Paramedical courses (4 batches) 123 Short course Psychiatric nursing 4 Special Education Students (class 8th -10th) 25 External MSW Trainees Posted in PRS 24 Senior Citizens (2 batches) 80 MPhil Trainees Posted in PRS for one 14 Parents of Mentally Retarded & Autistic Month Posting 20 children 19. Psychiatric Social Work 127 PUC & Degree 24 Block Placement Training Programme (BPTP) 127 14. Neurophysiology 37 20. Psychopharmacology 8 PhD 1 BE (Biotechnology) 4 MD/MS 14 MBBS 2 MTech 2 MPharm 2 MTech (Biotechnology) 1 21. Speech Pathology & Audiology 175 BTech (Biotechnology) 2 MS (ENT) 22 BTech 1 BSc (Speech & Hearing) 138 MBBS 1 DM/PDF-CAP 4 MSc 6 Bio-Medical & others 11 MSc (Life Sciences) 2 Others 15 Integrated BS.-MS course 1 MSc (Biotechnology) 1 Total 5082 BNYS 5 15. Neurosurgery 202 MCh (Neurosurgery) 35 Number of trainees who underwent training at NIMHANS MD/MS 167 16. Neurovirology 62 A total of 2945 students from various government/private institutions MD 58 across the country visited and underwent training at NIMHANS MPhil 3 during the period 1 April 2015-31 March 2016.
National Institute of Mental Health and Neuro Sciences 81 20th Convocation
20th Convocation Awardees
Golden Jubilee Award for the Best Outgoing Silver Jubilee Award for the Student in DM Neuroimaging Best Outgoing Student in MD & Interventional Radiology – Psychiatry – 2015 2015 Dr. Suhas G Dr. Subhendu Parida
Dr. D.L.N. Murthy Rao Memorial Prize for the Best Outgoing Student in Diploma in Psychiatry – 2015 Dr. Manasa S Seshadri
Dr. M.V. Govindaswamy Dr. M.V. Govindaswamy Memorial Prize for Scoring Memorial Prize for Scoring the the Highest Marks in MPhil Highest Marks in MPhil Clinical Psychiatric Social Work – 2015 Psychology – 2015 Ms. Joice Steffi Y Ms. Cassandra Shruti Sundaraja
Dr. R.N. Moorthy Award for Scoring the Highest Marks in MPhil Neurophysiology – 2015 Ms. Kala P Nair Dr. R.N. Moorthy Dr. R.N. Moorthy Award for Scoring the Award for Scoring the Highest Marks in MSc Highest Marks in MPhil Psychiatric Nursing –2015 Biophysics – 2015 Ms. Arpitha Elizabeth Ms. K Thangameenakshi Jolly
Dr. Anisya Vasanth Memorial Dr. Usha Punja Award for the Best Award for the Best Post-Graduate Resident in Outgoing Student in DM Neurology–2015 Neuroanaesthesia – 2015 Dr. Manjunath M Dr. Mohit Mittal Dr. Nitish Kamble
Institute Day Awardees
Best Out-Going Student in Diploma in Clinical Neurophysiology Technology (DCNT)—2015 Mr. Joby Jose
Dr. M.V. Infosys Foundation Govindaswamy & Dr. D.L.N. Murthy Rao Memorial Award for Excellence and Prize and Infosys Foundation Award Mukund Memorial Award for for Excellence for securing the highest Securing Distinction in Post-Basic marks in Post-Basic Diploma in Diploma in Neuro Science Nursing Psychiatric/Mental Health Nursing Examination held in July 2015 Examination held in July 2015 Capt. Aparna NR Lt .Col. Sandhya S Conferences/Symposia/ Workshops
Scientific Programs B. NATIONAL Organised at NIMHANS Biophysics A. INTERNATIONAL Dr. B Padmanabhan, Additional Professor, Dr. S Ramaswamy, inStem/ Neuroanaesthesia C-CAMP, Bengaluru, Dr. B Gopal, IISc, Bengaluru, workshop on Structural Biology: Introduction to Protein Crystallography, 15-18 Dr. GS Umamaheswara Rao, Professor, (i) Second Liverpool- April 2015. 35 members participated. NIMHANS Scientific Meeting, 29 September-1 October 2015 (ii) Third Liverpool- NIMHANS Scientific Meeting, 1-2 March 2016 Dr. B Padmanabhan, Additional Professor, Dr. S Ramaswamy, (iii) NIMHANS and United States India Education Foundation inStem/C-CAMP, Bengaluru, Dr. B Gopal, IISc, Bengaluru, (USIEF) Meeting, 15 March 2016. conducted 15th National Program Advisory Committee (PAC) BBMM Meeting, DST, Government of India, 25 -27 June 2015, 50 members participated. Neuro Imaging & Interventional Radiology Biostatistics Dr. Rose Dawn Bharath, Associate Professor, Mr. Rajanikant Panda, Scientific Officer, hands-on workshop on fMRI- Basic Methods, Dr. K Thennarasu, Professor and Head, Dr. Mariamma Philip, Ara Damansara Medical Centre, Malaysia, 18-22 February 2016. 20 Assistant Professor, national workshop on Statistical Methods in members participated. Medical Research and Introduction to SPSS, 10-12 July 2015. 60 members participated. Psychiatry
Dr. Mathew Varghese, Professor and Head, Dr. Arun Kandasamy, Assistant Professor, International Conference on Integrating Mental Health Care & Chronic Non-Communicable Disorders (organised by Gulbenkian Mental Health Platform, Portugal, in association with WHO and NIMHANS), 13-15 November 2015. 200 members participated.
Dr. T Sivakumar, Assistant Professor of Psychiatry, Dr. Krishna Prasad, National Workshop on Statistical Methods in Medical Research and Associate Professor of Psychiatry, Dr. Hareesh Angothu, Assistant Introduction to SPSS Professor of Nursing, Dr. Aarti Jagannathan, Assistant Professor of Dr. P Marimuthu, Additional Professor, Dr. Mariamma Philip, Psychiatric Social Work, Dr. Deepak Jayarajan, Assistant Professor Assistant Professor, national workshop on Statistical Methods in of Psychiatry, Dr. Jagadisha Thirthalli, Professor of Psychiatry, Dr. Behavioral Research, 28 -30 September 2015. 30 members participated. Geetha Desai, Additional Professor of Psychiatry, Dr. Devvarta Kumar, Additional Professor of Clinical Psychology, Dr. Poornima Dr. K Thennarasu, Professor and Head, Dr. P Marimuthu, Bhola, Associate Professor of Clinical Psychology, Dr. Radhakrishnan Additional Professor, Dr. Mariamma Philip, Assistant Professor, G, Assistant Professor of Nursing, Dr. Naveen Kumar, Additional Dr. B Binukumar, Assistant Professor, Ms. Prathyusha PV, Research Professor of Psychiatry, Dr. SK Chaturvedi, Professor of Psychiatry, Assistant, Mr. Ravi GS, Computer Programmer, national workshop international workshop on Learning from Best Practices of Disability on Research Methodology in Psychosocial Issues, 8 -10 February Sector: Implications for Psychiatric Rehabilitation, 19 September 2016. 20 members participated. 2015. 105 members participated.
86 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Families, 8-9 February 2016. 28 members participated.
Dr. Anisha Shah, Professor, Dr. Thomas Kishore, Associate Professor, Dr. Roopesh BN, Associate Professor, Dr. Veena AS, Assistant Professor, national workshop on Counselling Skills for Working with Children, Adults and Families, 8-9 February 2016. 43 members participated.
Dr. LN Suman, Professor, Dr. Veena AS, Assistant Professor, Dr. Kavita Jangam, Assistant Professor of Psychiatric Social Work, (i) CODE: National Workshop on Statistical Methods in Behavioral Research Conforming to Directives and Ethics- A Workshop on Ethical Issues in Trauma Informed Care, 10 June 2015. 20 members participated (ii) HOME: Handling and Overcoming Marital Estrangement- Child and Adolescent Psychiatry A Workshop on Managing Marital Trauma, 1 August 2015. 22 members participated (iii) AGED: Acquiring Greater Empowerment Dr. Satish C Girimaji, Professor and Head, Dr. Gururaj, Professor and Dignity - A Workshop on Managing Psychological Trauma due and Head of Epidemiology, interdepartmental workshop on Child to Elder Abuse, 3 October 2015. 22 members participated (iv) PACT: Mental Health in India: Catalyzing the Public Health Response, 20 Parent Awareness of Child Trauma- An Orientation Workshop on January 2016. Childhood Trauma, 30 January 2016, 18 members participated (v) HURT: Home Upbringing for Recovery from Trauma- A Workshop Dr. Shekar P Seshadri, Professor, conducted (i) Seminar on Kalikeya on Managing Child Exposure to Domestic Violence (CEDV), 30 Kale- for school teachers on Emotional and Behavioural Problems January 2016. 10 members participated. in Children with Learning Issues, 4 August, 2015. 100 members participated (ii) Seminar on Arambhikeya Arambha- for anganwadi Dr. Seema Mehrotra, Professor, Dr. Jyotsna Agrawal, Assistant teachers, 11 August 2015. 50 members participated. Professor, Feeling Good & Doing Well Trainers Workshop, 11-15 January 2016. 42 members participated. Dr. K John Vijay Sagar, Dr. SK Chaturvedi, Professor of Psychiatry, Dr. Harish T, Associate Professor of Psychiatry and Dr. Veena Dr. Seema Mehrotra, Professor Dr. Paulomi M Sudhir, Additional Satyanarayana, Assistant Professor of Clinical Psychology, Professor, Dr. Manoj K Sharma, Additional Professor, Dr. Manjula interdepartmental workshop on Ethics in Research for PhD scholars, M, Additional Professor, Stakeholders’ Meet: Enabling Excellence, 13 August 2015. 50 members participated. Mental Health and Wellbeing in Sportspersons, 29 January 2016. 60 members participated.
Clinical Psychology Dr. Seema Mehrotra, Professor, Strength Based Mentoring (SBM) Workshop (a) 20 June 2015. 16 members participated (b) 26 June Dr. Anisha Shah, Professor, workshop on (i) Emotion Focused 2015. 20 members participated Therapy with Adult Female Client, 27 July 2015, 4 August 2015, 5 August 2015, 28 December 2015. 17 members participated Dr. Seema Mehrotra, Professor, Fr. Rajeev, PhD Scholar, Ms. Janhavi (ii) Adult Psychotherapies: Constructivist Approach, 31 August Devdutt, PhD Scholar, Mr. Noufal TH, PhD Scholar, (i) Youth- 2015. 29 members participated (iii) Adult Psychotherapies: Three Pro Workshop (a) 25 July 2015. 40 members participated (b) 21 Approaches to Psychotherapy (Emotionally Focused/Cognitive/ August 2015. 35 members participated (c) 18 September 2015. 35- Psychodynamic), 4, 11, 21 and 23 September 2015. 25 members 40 members participated (d) 40 members participated (ii) SMART participated (iv) Orientation to Psychotherapies: From Theories Riders Trainer’s Workshop, 19 September 2015. 17 members to Practice, 5-6 October 2015. 32 members participated (v) Adult participated (iii) Workshop on Personal Growth Series – Postpone Psychotherapies: Constructivist, Emotionally Focused, Cognitive No More, 6-20 February 2016. 20 members participated and Psychodynamic Approaches, 19 October 2015. 6 members participated (vi) Orientation to Psychotherapies: From Theories Dr. Seema Mehrotra, Professor, workshop on Engage-to-Change (P3 to Practice, 29-30 October 2015. 43 members participated (vii) REACH Certificate Course), 14 August 2015. 25 members participated. Emotion Focused Therapy with Adult Female Client: Illustration of chair dialogue technique and discussion with reference to Dr. Seema Mehrotra, Professor, Dr. Jyotsna Agarwal, Assistant NIMHANS experiences, 6 January 2016. 6 members participated Professor, workshop on Self-Compassion, 19 December 2015. 23 (viii) Counseling Skills for Working with Children, Adults and members participated
National Institute of Mental Health and Neuro Sciences 87 Annual Report 2015-2016
Dr. Jamuna Rajeswaran, Additional Professor, Dr. Keshav Kumar, Dr. M Manjula, Additional Professor, Dr. Paulomi M Sudhir, Additional Professor, Dr. Rajakumari P Reddy, Assistant Professor, Additional Professor, Dr. Mahendra P Sharma, Professor and Head, (i) Continuing Education in Neuropsychology (CEN-2015), 5th National Workshop on Cognitive Behaviour Therapy: Principles and National Workshop on Neuropsychological Assessment and applications, 9-10 July 2015. 40 members participated. (ii) National Neuropsychological Rehabilitation: Roots to Fruits (NANR-RF Workshop on Cognitive Behaviour Therapy in Sexual Dysfunctions, 2015), 16-18 July 2015. 58 members participated. 7-8 January 2016. 38 members participated.
Dr. Paulomi M. Sudhir, Additional Professor, Ms. Lakshmi J, PhD Dr. M Manjula, Additional Professor, Ms. Seema P Nambiar, PhD Scholar, Mr. Vidhya Sagar, PhD Scholar, workshop on Understanding Scholar, Maintaining Healthy Relationships – A Workshop for Youth, and Managing Anxiety in Social Situations, 31 July 2015. 36 members 21 July 2015. 21 members participated. participated. Dr. M Manjula, Additional Professor, Ms. Seema P Nambiar, Dr. Paulomi M Sudhir, Additional Professor, Ms. Systla Rukmini, PhD Scholar, Ms. Lavanya TP, PhD Scholar, Maintaining Healthy PhD Scholar, workshop on Anxiety Disorders in the Perinatal Period Relationship – A Workshop for Youth, 28 July 2015. 34 members in the National Conference on Motherhood, 31 October 2015. 12 participated. members participated. Dr. M Manjula, Additional Professor, Ms. Lavanya TP, PhD Scholar, Dr. Paulomi M. Sudhir, Additional Professor, Dr. Mahendra P Ms. Ananya Sinha, PhD Scholar, Orientation to Mental Health Sharma, Professor and Head, Dr. Manjula M, Additional Professor, Problems in Youth, 29 August 2015. 18 members participated. conducted workshop on Cognitive Behaviour therapy for social anxiety disorder, 27-28 November 2015. 31 members participated. Dr. M Manjula, Additional Professor, Dr. Poornima Bhola, Associate Professor, workshop on Basic Skills for Counseling Youth, 7 November Dr. Paulomi M. Sudhir, Additional Professor, Dr. Seema Mehrotra, 2015. 23 members participated. Professor, workshop on Work Stress and Mental Health, NIMHANS Centre for Well Being (NCWB), Bengaluru, 11 September 2016. 6 Dr. Poornima Bhola, Associate Professor, Dr. SK Chaturvedi, members participated. Professor of Psychiatry, Leadership Skills & Team-building in Nursing, 30 September 2015. 40 members participated. Dr. Paulomi M. Sudhir, Additional Professor, Ms. Janhavi Devdutt, PhD Scholar, Ms. Anisha Khanna, Clinical Psychologist, Dr. Seema Dr. Roopesh BN, Associate Professor, (i) seminar on Behavioral Mehrotra, Professor, workshop on Work Stress and Mental Health, Management of Children in School, 13 April 2015. 22 members NCWB, Bengaluru, 14 March 2016. 7 members participated. participated (ii) national workshop on Behavioral Intervention in Autism Spectrum Disorder, 30 June 2015. 40 members participated. Dr. Manoj Kumar Sharma, Additional Professor, Dr. Nitin Anand, Assistant Professor, Mr. Prasad Reddy, PhD Scholar, Ms. Ashwini B, Dr. M Thomas Kishore, Associate Professor, Infants of mothers with Clinical Psychologist, Ms. Poornima Mahendru, Clinical Psychologist, mental health problems: Understanding bonding and attachment workshop on Screening Technology Addiction, NCWB, Bengaluru, through social-emotional developmental tasks, National Workshop 27 November 2015. 27 members participated. on Motherhood Mental Health, 31 October 2015. 20 members participated. Dr. Manoj Kumar Sharma, Additional Professor, Dr. Nitin Anand, Assistant Professor, workshop on (i) Exner Scoring System of Dr. M Thomas Kishore, Associate Professor, Dr. Devvarta Kumar, Rorschach Inkblot Test, 4, 10 and 11 September 2015. 21 members Additional Professor, Dr. Nitin Anand, Assistant Professor, national participated (ii) Wechsler Intelligence Scale for Children, Fourth workshop on Clinical Psychology: Promoting Mental Health, 5-6 Edition with India Norms (WISC-IV), 18, 21 and 26 of September February 2016. 63 members participated. 2015. 15 members participated. Dr. Veena Satyanarayana, Assistant Professor, Ms. Poornima Dr. M Manjula, Additional Professor, Mr. Vidhyasagar, PhD Scholar, Mahendru, Clinical Psychologist, national workshop on Mothers Ms. Seema P Nambiar, PhD Scholar, (i) Maintaining Healthy with Borderline Personality Disorder and Their Infants, 31 October Relationship – A Workshop for Youth, NCWB, Bengaluru, 4 July 2015. 18 members participated. 2015. 27 members participated (ii) national workshop on Emotional Regulation for Healthy Living, 27 October 2015. 17 members Dr. Aruna Rose Mary Kapanee, Assistant Professor, national participated. workshop on Dance/Movement & Drama Therapy: Creative Mental
88 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Health Approaches to Growth and Healing, 19 March 2016. 30 in Mental, Neurological Disorders and Injuries, 23 September 2015. members participated. 35 members participated.
Dr. Shantala Hegde, Assistant Professor, Dr. Mahendra P Sharma, Dr. Girish N, Additional Professor, Dr. Senthil Amudhan, Professor and Head, Dr. Shivaram Varambally, Additional Assistant Professor, interdepartmental workshop on Research Professor of Psychiatry, Dr. Aarti Jagannathan, Assistant Professor Methodology-2015, 10-12 December 2015. 49 members participated. of Psychiatric Social Work, Dr. Sneha J.Karmani, Sr. Resident of Psychiatry, Dr. Vinod Kumar, Jr. Research Fellow, NIMHANS Centre for Yoga, National Symposium on Understanding Cognition and Consciousness through Meditation and Music, 8 February 2016. 115 members participated.
Dr. Gitanjali Narayanan, Assistant Professor, Mr. Ashfak Ahamad, PDF in Psychiatric Rehabilitation, workshop on Psychological Interventions in Addictive Behaviours, 21 November 2015. 38 Workshop on Research Methodology members participated Dr. Girish N, Additional Professor, interdepartmental Training Dr. Jyotsna Agrawal, Assistant Professor, Dr. Nithya Poornima, Programme for Counsellors under NPCDCS, 29-30 March 2016. 29 Assistant Professor, Dr. Seema Mehrotra, Professor, Workshop on counselors from different districts of Karnataka participated. Essential Enrichment: Self-care for Women, NCWB, 18 March 2016. 8 members participated. Dr. Pradeep B S, Associate Professor, workshop on Advanced Epidemiology, 22-26 June 2015. 37 members participated. Dr. Jyotsna, Assistant Professor of Clinical Psychology, Dr. Seema Mehrotra, Professor of Clinical Psychology, workshop on Self- Dr. Pradeep BS, Associate Professor, Dr. G Gururaj, Professor and Compassion, NCWB, 19 December 2015. 20 members participated. Head, Training of Yuva Parivarthakas under Yuva Spandana, April 2015-March 2016 (four training sessions/programmes). 65 members Ms. Janhavi Devdutt, PhD Scholar, departmental workshop on participated. Youth-Pro, 15 May 2015. 45 students from City College participated. Dr. Pradeep BS, Associate Professor, Dr. Gautham MS, Assistant Professor, Open Academic Programme-2: Epidemiology and Epidemiology Application of Census Data, 5 December 2015. 35 members participated. Dr. Gururaj G, Professor and Head, Dr. Senthil Amudhan, Assistant Professor, Symposium on Child Mental Health in India: Catalysing the Public Health Response, 20 January 2016. 212 participants from different public, private and NGO sector organizations working for child mental health participated.
Inauguration of preconference professional development course: by Dr. BN Gangadhar, Director, NIMHANS, Dr. Prabhu, National President, IAOH, Dr. Jayaram, Dean (Neurosciences), NIMHANS, Dr Sekar K, Registrar, NIMHANS, Dr. Gururaj G, Professor & Head, Dept. of Epidemiology.
Dr. Gautham MS, Assistant Professor, Dr. Gururaj G, Professor Symposium on Child Mental Health in India: Catalysing the Public Health and Head, (i) interdepartmental workshop on Capacity Building Response of Industrial Medical Officers in Prevention and Management of Dr. Girish N, Additional Professor, Dr. Gautham MS, Assistant NCDs and MSUDs, 7-10 July 2015. 34 members participated (ii) Professor, Open Academic Programme-1: Public Health Perspectives Preconference Professional Development Courses on (a) Mental
National Institute of Mental Health and Neuro Sciences 89 Annual Report 2015-2016 and Substance Use Disorders in Workplaces (b) Injury Prevention Realtime PCR training Course, 29-30 October 2015. 15 members in Workplaces (c) Making Sense of Occupational Health Data. participated. OCCUON-2016, 17 February 2016. 183 members participated. Dr. MM Srinivas Bharath, Additional Professor, Dr. N Gayathri, Dr. Gautham MS, Assistant Professor, Sensitization of Industrial Professor of Neuropathology, Dr. BK Chandra Shekhar Sagar, Stakeholders from Kolar District to MNSUDs and NCD Control in Additional Professor of Neuropathology, Mito Symposium 2015, 22 Workplaces, 8 May 2015. 20 members participated August 2015. 67 members participated.
Dr. Mahamood Sharriff, MPH student, Sensitization of government stakeholders from Kolar district in COTPA, Office of the Deputy Commissioner, Kolar, 24 March 2016.
Mental Health Education
Dr. KS Meena, Assistant Professor, workshop on Promoting Dignity through Cognizance of Facts about Mental Illness, 8 October 2015.
50 members participated. Mito Symposium 2015
Dr. KS Meena, Assistant Professor, Dr. Prasanthi Nattala, Associate Dr. Nandakumar DN, Additional Professor, (i) workshop on Bio- Professor of Nursing, Dr. Pratima Murthy, Professor of Psychiatry, Dr. medical Waste Management, 24 August 2015. 28 members participated Jagannath, Consultant, Anti-Tobacco Cell, Government of Karnataka, (ii) workshop on Pre-analytical Errors in Clinical Laboratories, 29 one-day workshop on Recognizing Harmful Use of Tobacco and How August 2015. 17 members participated (iii) training in Initialization, to Quit, 5 March 2016. 55 members participated. Operation, Daily Maintenance, Quality Control and Analysis of Sample in Access2 Immunoassay System, 30 September 2015. 10 members participated (iv) workshop on Sample Collection Using Vacuum Neuroanaesthesia System of Collection, Biosafety and Pre-Analytical Errors, 13 October 2015. 151 members participated (v) workshop on Daily Internal Quality The Department of Neuroanaesthesia, 17th Annual Conference Evaluation, 22 December 2015. 11 members participated (vi) training of Indian Society of Neuroanaesthesiology and Critical Care, 5-7 in Initialization, Operation, Daily Maintenance, Quality Control and February 2016. 450 members participated. Analysis of Sample in AU640 & AU680, 27 January 2016. 13 members participated (vii) workshop on Quality Indicators as per NABL112, 29 Dr. Ramesh VJ, Professor and Head, Symposium on Neuro-Critical February 2016. 13 members participated (viii) workshop on Preventive, Care, 24th Annual National Conference of Neurotrauma Society of Corrective Actions and Resolution of Non-Conformities, 30 March India, 21-23 August 2015. 350 members participated. 2016. 9 members participated.
Dr. Radhakrishnan M, Additional Professor, Dr. Ramesh VJ, Professor and Head, ENLS preconference workshop, 4 February Neuro Imaging & Interventional 2016. 125 members participated. Radiology
Dr. M Radhakrishnan, Additional Professor, National Trauma Life Dr. AK Gupta, Professor and Head, National Workshop, ISVIR-2016, Support, preconference workshop, National Neuro-trauma Society 18-21 February 2016. 300 members participated. Conference, 21 August 2015. 75 members participated.
Neurological Rehabilitation Neurochemistry Dr. Anupam Gupta, Additional Professor, Dr. Meeka Khanna, Dr. Rita Christopher, Professor and Head, (i) Training in liquid Assistant Professor, Dr. Rashmi Krishnan, Assistant Professor, Dr. chromatography-tandem mass spectrometry, 17-19 August 2015. Abhishek Srivastava, National Symposium on Bladder, Bowel & 10 members participated (ii) Hands-on training in Neobase Sexual Dysfunction following Spinal Cord Injuries, Neurotrauma LC MS-MS, 12 September 2015. 10 members participated (iii) Conference 2015, 21-23 August 2015. 350 doctors participated.
90 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Neuromicrobiology Anastamosis and Brain Dissection Workshop, 1-3 January 2016. 30 members participated. Dr. R Ravikumar, Professor, Dr. Shripad A Patil, Professor and Head, hands-on training in Polymerase Chain Reaction Techniques, 1-15 February 2016. 6 members participated.
Neuropathology
Human Brain Bank and the Department of Neurosurgery, 1st NIMHANS Microvascular Anastomosis and Brain Dissection Workshop, 1-3 January 2016.
Neurophysiology
Dr. Bindu M Kutty, Professor, national workshop on Mind Science, Faculty and participants of the st1 NIMHANS Neurovascular Anastamosis and 11 May 2015. 30 members participated. Brain Dissection Workshop
Dr. Bindu M Kutty, Professor, Dr. John P John, Professor of Psychiatry, Neurovirology inaugural symposium, Cognitive Neuroscience Society of India, 21 June 2015. 75 members participated. Dr. Ravi Vasanthapuram, Professor and Head, Dr. Anita Desai, Professor, Dr. Reeta Mani, Associate Professor, (i) Hands-on training in Good Laboratory Practices, Reporting and Quality Assurance in JE eurosurgery N Testing, as part of CDC, USA funded project entitled Strengthening Surveillance for Japanese Encephalitis in India, 11-14 August 2015. Dr. Indira Devi, Professor, Organising Secretary, 24th Annual National 30 members participated (ii) Hands-on training in Diagnosis and Conference of Neurotrauma Society of India, 21-23 August 2015. Detection of Non-JE AES Pathogens, 7-10 September 2015. 12 340 delegates participated. members participated (iii) training workshop for project coordinators, lab coordinator and Data Managers, as part of CDC, USA funded Dr. Indira Devi, Professor, Dr. Nishanth Sadashiva, Assistant project entitled Strengthening Surveillance for Japanese Encephalitis Professor, in association with Indian Society for Emergency Medicine, in India (a) 22-24 September 2015. 16 members participated. (b) 9-11 workshop on National Trauma Life Support, 20 August 2015. 100 February 2016. 24 members participated. members participated.
Nursing
Dr. Ramachandra, Additional Professor and Head, workshop on Nurses’ Role in Disaster Management, 21 November 2015. 65 members participated.
Dr. K Lalitha, Professor, (i) half-day workshop on Critique of Mental Health Bill-2013, 15 October 2015. 110 members participated (ii) half-day workshop on Psychosocial Perspectives of Patients towards Technological Advances, 26 October 2015. 43 members participated.
Dr. Sailaxmi Gandhi, Associate Professor, Mrs. Rosamma Chacko, Prof. Shobini Rao delivering the AK Banerjee Oration at the 24th Annual National Conference of Neurotrauma Society of India Focus group discussion on suicide prevention with family members of persons with mental illness, 11 sessions, between April 2015 and Dr. Nupur Pruthi, Additional Professor, 1st NIMHANS Microvascular March 2016. 12 members participated.
National Institute of Mental Health and Neuro Sciences 91 Annual Report 2015-2016
Dr. Sailaxmi Gandhi, Associate Professor, Dr. Ramachandra, Professor, Symposium on Schizophrenia, 18 November 2015. 30 Additional Professor and Head, Dr. K Lalitha, Professor, Dr. Prasanthi members participated. Nattala, Associate Professor, Dr. Radhakrishnan G, Assistant Professor, (i) workshop on Stress Management for Caregivers Ms. Leela Savio, Ms. Kalaivani PL, Dr. Prasanthi Nattala, Associate of Persons with Mental Illness, 9 October 2015. 12 members Professor, workshop on Psychopharmacology and basic Psychiatric participated (ii) workshop on Management of Caregiver Burden for Nursing skills, 16-17 April 2015. 25 members participated. Family Members of Persons with Chronic Neurological and Neuro- Surgical Conditions, 19 October 2015. 50 members participated (iii) workshop on Critique on Mental Health Care Bill, 2013, 15 October College of Nursing 2015. 110 members participated. Dr. Ramachandra, Additional Professor and Head of Nursing, Peace Dr. Sailaxmi Gandhi, Associate Professor, Satellite Conference of Education Programme, 16 April 2015. 320 members participated. Neurotrauma Nursing 2015, 24th Annual National Neurotrauma Conference 2015, 21-23 August 2015. 124 members participated. Dr. BV Kathyayani, Principal, Dr. Pratibha Swamy, Associate Professor and Vice Principal, Dr. KN Jayanthi, Lecturer, Mr. K Kannan, Clinical Instructor, workshop on Team Building in Nursing: Bridges to the Future, 30 September 2015. 40 members participated.
Dr. BV Kathyayani, Principal, Dr. Priya Baby, Lecturer, Mrs. P Vijayalakshmi, Clinical Instructor, national workshop on Transforming Care at Bedside: Ameliorates Patient Care and Improves Vitality of Health Care Team, 11 January 2016. 135 members participated.
Dr. BV Kathyayani, Principal, Dr. S Valliammal, Lecturer, Mrs. HN Poornima, Lecturer, Mrs. Sathyavathy, Clinical Instructor, Mrs. T Suseela, Clinical Instructor, Mrs. Bingi Rajeswari, Clinical Instructor, national workshop on Psychosocial Issues and Role of a Nurse in Child Adoption, 11 March 2016. 116 members participated. 24th Annual National Neurotrauma Conference 2015
Dr. Prasanthi Nattala, Associate Professor, Dr. Meena KS, Assistant Professor of Mental Health Education, Dr. Harish T, Associate Psychiatry Professor of Psychiatry, Dr. Sundarnag, Mrs. Kalaivani PL, Mrs. Emily Veena, Mrs. Lydia Jeevan, workshop on Promoting Dignity Dr. BN Gangadhar, Professor and Director, NIMHANS, Dr. through Cognizance of Facts about Mental Illness, 8 October 2015. Shivarama Varambally, Additional Professor, Dr. Bindu M Kutty, 50 members participated. Professor of Neurophysiology, Dr. Mahendra Sharma, Professor and Head of Clinical Psychology, Mr. Dipnkar Khanna, Garden of Dr. Radhakrishnan, Assistant Professor, workshop on Role of Samadi, Yelahanka, Bengaluru, Dr. Aarti Jagannathan, Assistant Nurses in Disaster Management, 21 November 2015. 65 members Professor of Psychiatric Social Work, Dr. Shantala Hegde, Assistant participated. Professor of Clinical Psychology, Dr. Sneha J Karmani, Sr. Resident, National Symposium on Integrating Scientific and Contemplative Approaches to Explore the Mind, 6 December 2015. 134 members participated.
Dr. Prabha S Chandra, Professor, Orientation to NCWB services for medical officers across India, 7 July 2015. 35 members participated.
Dr. Prabha S Chandra, Professor, Dr. Senthil Kumar Reddi, Associate Professor, Smt. D Padmavathy, Staff Nurse, Gatekeeper Training in Suicide Prevention, 24 June 2015. 10 members participated. Workshop on Role of Nurses in Disaster Management
Ms. Emily Veena, Ms. Lydia Jeevan, Dr. Prasanthi Nattala, Associate Dr. Srikala Bharath, Professor, national workshops on Empowering
92 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Adolescents using Life Skills Education, 2-4 April 2015, 24-26 June for Central Institute of Home Science College students, Bengaluru, 2015, 29-31 October 2015. 29-35 members participated. NCWB, 22 May 2015. 40 members participated.
Dr. Srikala Bharath, Professor, Dr. N Manjunatha, Assistant Professor, CME- Relapse prevention in schizophrenia, 11 July 2015. Psychiatric Rehabilitation 96 members participated. Faculty and students associated with Psychiatric Rehabilitation Dr. SK Chaturvedi, Professor, Prof. Norman Sartorius, former Director Services, Dept. of Psychiatry organised two major workshops and of the Department of Mental Health, World Health Organization symposia: Nuts and Bolts of Starting and Running Psychiatric (WHO), interdepartmental 4th Leadership & Professional Skills Rehabilitation Services on 4 April 2015 and Quality of Life in Workshop for Early Career Psychiatrists, 14-16 January 2016. 16 Chronic Mental Illness: Exploring New Frontiers on 30 January 2016. members participated. About 100 members took part in both the events. The Psychiatric Rehabilitation Services team, on the occasion of International Day Dr. Geetha Desai, Additional Professor, Dr. Harish, Associate Professor, for persons with Disability 2016, also organised workshop on Mental Dr. Prabha S Chandra, Professor, National Conference on Motherhood Illness Being a Disability for the District Disabled Welfare Officers and Mental Health, 31 October 2015. 150 members participated. (DDWOs) in Karnataka State, in collaboration with the Directorate of Disability, Government of Karnataka on 15 December 2015. Dr. Geetha Desai, Additional Professor, Dr. Ashlesha Bagadia, national workshop on Decision Making for Psychotropic Use in Pregnant Dr. Sailaxmi Gandhi, Associate Professor of Nursing, Dr. SK Women with Mental Illness, National Conference on Motherhood and Chaturvedi, Professor of Psychiatry, Dr. Jagadisha T, Professor of Mental Health, 31 October 2015. 40 members participated. Psychiatry, Dr. Sivakumar T, Assistant Professor, Dr. Poornima Bhola, Associate Professor of Clinical Psychology, Dr. Nirmala Dr. Harish T, Associate Professor, Mr. Ragesh, national workshop on BP, Additional Professor of Psychiatric Social Work, Dr. Naveen Mother Infant Bonding in Postpartum Psychiatric Illness, National Kumar C, Associate Professor, Dr. Devvarta K, Additional Professor Conference on Motherhood and Mental Health, 31 October 2015. of Clinical Psychology, et al., Domestic Skills: A workshop for the 40 members participated. People, by the People, of the People, (a) 15 April 2015. 25 members participated (b) 22 April 2015. 34 members participated. Dr. Harish T, Associate Professor, workshop on Mental Health of Women in Pre/Post-Natal Mothers, National Conference on Dr. Poornima Bhola, Associate Professor of Clinical Psychology, Motherhood and Mental Health, 31 October 2015. 50 members National VKN Programme: Social Skills Assessment and Training, participated. 29 January 2016. 40 members participated.
Dr. Krishna Prasad M, Associate Professor, Dr. Abhishek Pathak, Dr. Dr. Deepak Jayarajan, Assistant Professor of Psychiatry, Dr. Poornima SK Chaturvedi, Professor, national workshop on Quality of Life in Bhola, Associate Professor of Clinical Psychology, Dr. Hareesh Chronic Mental Illness: Exploring New Frontiers, 30 January 2016. Angothu, Assistant Professor of Psychiatry, Ms. Vidhi Tyagi, Clinical 80 members participated. Psychologist, Dr. Sivakumar Thanapal, Assistant Professor of Psychiatry, Dr. Krishna Prasad, Associate Professor of Psychiatry, Dr. Dr. Urvakhsh M Mehta, Assistant Professor, 1st National Symposium Abhishek Pathak, Sr. Resident, workshop on Cross-Cultural Issues on Non-invasive Brain Stimulation, 20 September 2015. 180 members and the Assessment & Measurement of Quality of Life in Mental participated. Illnesses, Symposium on Quality of Life in Chronic Mental Illness: Exploring New Frontiers, 30 January 2016. 80 members participated. Dr. N Manjunatha, Assistant Professor, (i) workshop on Mental Health at Primary Care, 27 February 2016 (ii) National CME- Essentials of Psychiatry for all Medical Doctors, 19 March 2016. 24 members participated.
Smt. D Padmavathy, Staff Nurse, Ms Taranum Taj, Assistant Coordinator, Orientation to NCWB services for NGO-Sochara, NCWB, 8 September 2015. 21 members participated. Workshop on Cross-Cultural Issues and the Assessment & Measurement of Smt. D Padmavathy, Staff Nurse, Orientation to NCWB Services Quality of Life in Mental Illnesses
National Institute of Mental Health and Neuro Sciences 93 Annual Report 2015-2016
Dr. Radhakrishnan G, Assistant Professor of Nursing, Dr. and staff of Madurai Institute of Social Sciences, Madurai, 23-26 Sailaxmi Gandhi, Associate Professor of Nursing, Dr. Poornima September 2015 (iv) Workshop on Advanced Training Programme on Bhola, Associate Professor of Clinical Psychology, Dr. Jagadisha Mental Health, for members of ActionAid, Kashmir, 28 September Thirthalli, Professor of Psychiatry, Dr. SK Chaturvedi, Professor of - 9 October 2015 (v) Workshop on Psychosocial Care in Disaster Psychiatry, Dr. Krishna Prasad, Associate Professor of Psychiatry, Management, for faculty and staff of Kristhu Jayanthi College, 9-11 Dr Sivakumar T, Assistant Professor of Psychiatry, Dr. Hareesh December 2015 (vi) Workshop on Recent Trends in Psychiatric Angothu, Assistant Professor of Nursing, Dr. Deepak Jayarajan, Social Work, for participants from St. Ambrose University School of Assistant Professor of Psychiatry, Dr. Aarti Jagannathan, Assistant Social Work, Davenport, Lowa, USA, 5-6 January 2016 (vii) TOT Professor of Psychiatric Social Work, national workshop on Workshop on Psychosocial Care for Children in Conflict with Law Nurses’ Role in Psychiatric Rehabilitation Services, 5 March 2016. in Kerala, 18-23 January 2016 (viii) Workshop on Recent Trends 45 members participated. in Psychiatric Social Work, participants from Zurich University of Applied Sciences, Zurich, Germany, 30 January 2016
Dr. D Muralidhar, Professor, Dr. Gobinda Mahji, Assistant Professor, national workshop on Research Methodology in Psychosocial Issues, 8-10 February 2016. 27 members participated.
Dr. R Dhanasekara Pandian, Additional Professor, (i) interdepartmental symposium on Clinical Social Work Practice in Mental Health- An Update, 29 July 2015. 80 members participated (ii) workshop on Psychiatric Social Work in Child, Family and Community Mental Health, 29 September 2015. 150 members participated.
Dr. A Thirumoorthy, Additional Professor, (i) national workshop on Mental Health Enrichment Training for TNPVP, Chennai, National Workshop on Nurses’ Role in Psychiatric Rehabilitation Services (a) 16-17 April 2015. 40-45 members participated (b) 20-21 May 2015. 35 members participated (c) 29-30 May 2015. 40-42 members Dr. T Sivakumar, Assistant Professor, (i) national workshops on participated (d) 17-18 June 2015. 40 members participated (ii) Caregivers support and education programme, 21 April 2015, 19 May national workshop on Solution Focused Therapy, 29 February 2016. 2015, 16 June 2015, 21 July 2015, 18 August 2015, 15 September 37 members participated 2015, 20 October 2015. 41-72 members participated (ii) national workshop on Caregivers support and education programme on Dr. BP Nirmala, Additional Professor, Interdepartmental Quiz Swavlamban Health Insurance Scheme, 23 February 2016. 64 Competition (DNR), 3 December 2015. 22 members participated. members participated (iii) sensitization programme for staff of The Association of People with Disability (APD), 16-25 July 2015. 5 Dr. N Janardhana, Associate Professor, workshop on Mental Illness members participated (iv) national workshop on Ageing and Mental and Disability for the Field Staff of APD, 15-18 February 2016. 24 Health Issues in Down Syndrome, 20 June 2015. 40 members members participated. participated (v) interdepartmental workshop on Virtual Knowledge Network NIMHANS ECHO: Road to Recovery, 26 June 2015, 24 Dr. Aarti Jaganathan, Assistant Professor, (i) Inclusion Matters: July 2015, 28 August 2015, 29 January 2016, 26 February 2016. 20 A Symposium on Disability and Inclusion, 3 December 2015. 50 members participated in each session. members participated (ii) Sensitization Programme for Volunteers, NCWB, 1 August 2015. 36 members participated.
Psychiatric Social Work Dr. Vranda, Assistant Professor, (i) workshop on Mental Health Issues of Women with Intimate Partner Violence/Domestic Violence, Dr. K Sekar, Professor and Head, (i) Regional Consultative Workshop NCWB, 22 June 2015. 50 members participated (ii) workshop on Psychosocial Care for Children in Difficult Circumstances for on Promotion of Mental Health and Psychological Well-being of practitioners, academicians, researchers and members of INGOs, Adolescents using Life Skills Approach, 7-8 September 2015. 41 NGOs, UNO , 8-10 April 2015 (ii) Sensitisation Programme on members participated. School Mental Health for SCARF Chennai, 16-17 April 2015 (iii) Workshop on Recent Trends in Psychiatric Social Work, for faculty Dr. E Senu, Assistant Professor, sensitization programme on Handling
94 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Difficult Patients for support staff and security personnel of Centre Scientific Programs for Addiction Medicine, 2 September 2015. Organised Outside NIMHANS Dr. Harish T, Associate Professor of Psychiatry, Dr. Aarti Jagannathan, A. International Assistant Professor, interdepartmental workshop on Mental Illness being a Disability, International Day of Persons with Disability, 15 December 2015. 46 members participated. Child & Adolescent Psychiatry
Dr. Bino Thomas, Assistant Professor, (i) workshop on Recent Trends Dr. Shekhar P Seshadri, Professor, workshop on (i) Psychological and in Psychiatric Social Work (a) 9-12 December 2015. 30 members Developmental Needs of Children, Visthar, Bengaluru, 25-27 August participated (b) 30 January 2016. 12 members participated (ii) 2015. 40 members participated (ii) Life Skills, Faizabad, UP, 4-5 Orientation to NCWB Services for representatives from St. Thomas September 2015. 80 members participated Church, 17 March 2016. 5 members participated. Dr. K John Vijay Sagar, Additional Professor, workshop on (i) Child Dr. C Jaya Kumar, Assistant Professor, Dr. Sekar, Professor and Head, Sexual Abuse and Disruptive Behaviour Disorders, WPA Regional workshop on Psychosocial Care in Disaster Management, 21- 25 Congress, Kochi, 27 September 2015. 35 members participated (ii) March 2016. 33 members participated. workshop on Management of Child Sexual Abuse for mental health professionals, chairpersons of the child welfare committees, and others Dr. Kavita Jangam, Assistant Professor, Dr Bino Thomas, Assistant working, Kerala IPS, Cochin Branch, 7 February 2016. 30 members Professor and NCWB Team, workshop on Positive Parenting, (a) participated. 28 November 2015. 25 members participated. (b) 5 March 2016. 21 members participated. Clinical Psychology Dr. E Aravind Raj, Assistant Professor, workshop on (i) School Mental Health for Volunteers of Corporate Sector – A CSR Initiative, Dr. Keshav Kumar, Additional Professor, workshop on Tweaking 5-7 January 2016. 20 members participated (ii) Psychosocial Care in Neural Networks to Improve Cognitive Functions: Neuropsychological Disaster Management, 21-25 March 2016. 34 members participated. Rehabilitation Revisited, Symposium at the Centenary Conference on Psychology: An International Event, University of Calcutta, Kolkata, Psychopharmacology 9-11 October 2015.
Dr. Chittaranjan Andrade, Professor and Head, workshop on Meta- Dr. Poornima Bhola, Associate Professor, Dr. Pallavi Banerjee, Analysis, Part 1 and Part 2, 30 October 2015 and 6 November 2015. Assistant Professor, Ms. Chetna Duggal, Assistant Professor, 50 members participated in each session. international symposium on Trainees, Therapists and Clients: A Confluence of Participant Voices in Psychotherapy, Centenary Conference on Psychology- An International Event, Kolkata, 9-11 Speech Pathology & Audiology October 2015. 200 members participated.
Dr. Y Pradeep, Speech Therapist, Dr. R Aravind Kumar, Speech Therapist, Dr. Yamini, Assistant Professor, in collaboration with Neuro Imaging & Interventional ISHA-Bengaluru Chapter, half-day seminar on Meaning: Where is Radiology it?, 17 October 2015. 140 members participated. Dr. AK Gupta, Professor and Head, International Symposium on Photonics Applications and Nanomaterials, Trivandrum, 28-30 Transfusion Medicine & October 2015. 250 members participated. Haematology Neurology The Department of Transfusion Medicine & Haematology (i) technical seminar in association with Affymetrix USA, on Genomic Dr. Pramod Kumar Pal, Professor, 1st International Annual Conference Perspective in Medical Oncology, 25 May 2015 (ii) Bone Marrow of the Movement Disorders Society of India (MDSICON-2016), Awareness Program Cum Donor Registration, 6 June 2016. Chennai, 8-10 January 2016. 400 members participated
National Institute of Mental Health and Neuro Sciences 95 Annual Report 2015-2016
Neuromicrobiology Dr. K Thennarasu, Professor and Head, Dr. Jashobanta Mahapatra, MHI, Cuttack, training programme on Biostatistics and Research Methodology, Mental Health Institute, Cuttack, Orissa, 28 March-2 Dr. R Ravikumar, Professor, workshop on Proteogenomics, Does April 2016. 12 members participated. Proteogenomics Study Give Answer to the Diagnosis of Infectious and Non-Infectious Diseases of Nervous System, 6th International Dr. K Thennarasu, Professor and Head, Dr. Mariamma Philip, Conference and Expo on Proteomics, Atlanta, USA, 29-31 March Assistant Professor, regional workshop on Application of Statistical 2016. 25 members participated. Techniques in Biological Research, ICAR-National Dairy Research Institute (NDRI), Bengaluru, 2-4 March 2016. 20 members Neurovirology participated.
Dr. Mariamma Philip, Assistant Professor, (i) interdepartmental Dr. V Ravi, Professor and Head, international bi-regional workshop on workshop on Data Analysis & Statistical Inference, Raja Rajeshwari Strengthening the Capacity of Japanese Encephalitis ( JE) Laboratory Medical College, Bengaluru, 5-9 October 2015. 40 members Network in the WHO South-East Asia and Western Pacific Region, participated (ii) national workshop on Statistical Methods in Bangkok, Thailand, 17-21 August 2015. 24 members participated. Nutritional Research, Indian Dietetic Association, Bengaluru, 19-20 November 2015. 200 members participated (iii) workshop on Data Psychiatry Analysis using SPSS, Government College of Nursing, Bengaluru, 29 February 2016. 25 members participated. Dr. Prabha S Chandra, Professor, (i) MRC-DBT workshop on RCT Dr. Mariamma Philip, Assistant Professor, Ms. PV Prathyusha, for Reducing Second Hand Smoke Exposure in Pregnant Women, Research Assistant, Mr. Ravi GS, Computer Programmer, national Liverpool, UK, 9-12 September 2015. 10 members participated workshop on Statistical Analysis of Data - Nursing Consortium, (ii) workshop on MRC-DBT Qualitative Methods, Dhaka, 21-23 St. John’s Medical College, Bengaluru, 7-12 December 2015. 20 February 2016. 10 members participated. members participated. Dr. Pratima Murthy, Professor, (i) international training programme Dr. B Binukumar, Assistant Professor, regional pre-conference on Tobacco Cessation Intervention, Timor Leste, August 2015 (ii) workshop on Biostatistics, KEM Medical College, Mumbai, 11 International Conference on Tobacco M-Cessation, WHO, Geneva, February 2016. 80 members participated. 9-11 December 2015 (iii) International Conference on mHealth for TB-Tobacco: Advancing Efforts Towards Prevention and Dr. B Binukumar, Assistant Professor, Dr. Anil C Mathew, Management of Tuberculosis and Tobacco Consumption, WHO, Coimbatore, departmental workshop on Bio-statistical Methods in Geneva, American University, Cairo, Egypt, 24-25 February 2016. Clinical Research, St. Thomas College, Pala, Kerala, 26-27 February 2016. 30 members participated. B. NaTIONAL
Biostatistics Clinical Psychology
Dr. K Thennarasu, Professor and Head, (i) national workshop on Dr. Mahendra P Sharma, Professor and Head, Ms. Lakshmi, Ms. Research Methodology, Hassan Institute of Medical Sciences, Sonal Mathur, workshop on Cognitive Behaviour Therapy: Principles Hassan, Karnataka, 12-14 August 2015. 70 members participated and Applications, Department of Psychiatry, Gitanjali Medical (ii) workshop on SPSS Online Training Portal (SOTP), Mysore College and Hospital, Udaipur, 18-19 April 2015. 50 members Medical College, Mysore, Karnataka, 18 August 2015. 50 members participated. participated (iii) CME on Research Methodology and Dissertation Writing, Tanjavur Medical College, Thanjavur, Tamil Nadu, 19-20 Dr. Mahendra P Sharma, Professor and Head, Dr. Paulomi M December 2015. 110 members participated. Sudhir, Additional Professor, Dr. M Manjula, Additional Professor, Symposium on Contemporary Cognitive Behaviour Therapies for Dr. K Thennarasu, Professor and Head, Dr. B Binukumar, Emotional Disorders: Application of Transdiagnostic Approaches, Assistant Professor, national workshop on Statistical Data Analysis 42nd National Annual Conference of Indian Association of Clinical in Healthcare-2015, National Institute of Technology, Raipur, Psychologists, RIMS, Imphal, Manipur, 25-27 February 2016. 70 Chhattisgarh, 31 October 2015. 100 members participated. members participated.
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Dr. Uma Hirisave, Professor, workshop on Addressing and Handling Dr. M Manjula, Additional Professor, Dr. Ashish Srivastava, Mental Health Issues of Adolescents, St. Joseph’s PU College, workshop on Management of Social Anxiety using Cognitive Bengaluru, 29 July 2015. 40 teachers participated. Behaviour Therapy, Psychiatric Society of Goa, Goa, 13 March 2016. 50 members participated. Dr. Anisha Shah, Professor, workshop on Recent Advances in Couple and Family Therapy, Bengaluru, 23 July 2015. 25 members Dr. Devvarta Kumar, Additional Professor, workshop on CBT for participated. Delusions and Hallucinations in IPS South Zone PG Training Program, Kottayam, 8-9 August 2015. 50 members participated. Dr. LN Suman, Professor, TEACH: Trauma, Emergency and Crises Help-A Workshop on Crisis Management in Academic Settings, Dr. Poornima Bhola, Associate Professor, Dr. Paulomi M Sudhir, Thrissur, Kerala, 22 September 2015. 30 members participated. Additional Professor, workshop on (i) Behavioral Wellness for employees of GE, Gurgaon, 5 February 2016. 19 members participated Dr. Seema Mehrotra, Professor, (i) workshop on Mind Matters, (ii) Behavioral Wellness, Bangalore, 11-12 August 2015. 25 members City College, Bengaluru, 15 May 2015. 30 members participated (ii) participated. Engage-to-Change (E2C), City College, Bengaluru, 28 May 2015. 30 members participated (iii) Orientation regarding Positive Psychology Dr. Poornima Bhola, Associate Professor, Ms. Ananya Sinha, PhD Unit (PPU) programmes and initiatives, City College, Bengaluru, 29 Scholar, workshop on Non-suicidal Self-injury: Assessment and September 2015. 30 members participated. Intervention Frameworks, 13th Biennial Conference of Indian Association of Child and Adolescent Mental Health (IACAMCON), Dr. Paulomi M Sudhir, Additional Professor, Dr. Poornima Bhola, Pune, 19-21 November 2015. 30 members participated. Associate Professor, workshop on Behavioral Wellness for Employees of GE, Noida, 4 February 2016. 25 members participated. Dr. Poornima Bhola, Associate Professor, Ms. Dharani Devi, PhD Scholar, national workshop on Psychotherapy Process and Research; Dr. Manoj Kumar Sharma, Additional Professor, conducted (i) Process Variables in Practice, Manipal University, Manipal, 21-22 workshop on Outreach Workshop- Substance Use and Addiction August, 2015. 30 members participated. to Other Behaviors, Bishop Cotton Women’s Christian College, Bengaluru, 6 August 2015 (ii) outreach workshop on Addiction to Dr. Roopesh BN, Associate Professor, (i) seminar on Technology, Kendriya Vidyalaya, ASC Centre, Bengaluru, (a) 19 Neuropsychological Rehabilitation, Central University Karnataka, September 2015 (b) 31October 2015 (c) 28 November 2015 (iii) Gulbarga, 8 April 2015. 30 members participated (ii) seminar on outreach workshop on Internet Addiction & Its Prevention, Dayanand Identification of Specific Learning Disability, Chinmaya Vidyalaya, Sagar College of Engineering, Bengaluru, 3 March 2016. Koramangala, Bengaluru, 26 Mat 2015. 110 members participated (iii) seminar on The Adolescents Factors & Parental Responsibilities, Dr. M Manjula, Additional Professor, Mr. Vidhyasagar K, PhD Shantiniketan School, Bengaluru, 4 August 2015. 50 members Scholar, workshop on (i) Handling Academic Stress Effectively, participated (iv) workshop on Identification of Autism Spectrum SSMRV College, Bengaluru, 9 April 2015. 100 members participated Disorder, LGB Regional Institute of Mental Health, Tezpur, Assam, (ii) Managing Stress and Enhancing Wellness, ABB Global, 9-10 September 2015 (v) workshop on Study Skills for the Middle Bengaluru, 11 February 2016. 130 members participated School Children, Aradhana Academy, Bengaluru, 18 January 2016. 160 members participated (vi) workshop on The Study Skills for the Dr. M Manjula, Additional Professor, workshop on (i) Study Skills High School Children, Aradhana Academy, Bengaluru, 18 January and Handling Examination Anxiety, Sanjay Gandhi College of 2016. 150 members participated (vii) workshop on Neuropsychological Education, Bengaluru, 1 June 2015. 80 members participated (ii) Assessment and Cognitive Rehabilitation, Chennai, 21 January 2016. Cognitive Behavioural Strategies for Emotional and Psychological 40 members participated (viii) seminar on Help to Correct Juvenile Trauma, 16th Annual Conference of Catholic Psychologists of India Problems in India, GFSU, Gandhinagar, Gujarat, 30 January 2016. (CCPI), Sampurna Montfort College, Bengaluru, 9-10 October 50 members participated 2015. 50 members participated. Dr. Jyotsna Agrawal, Assistant Professor, (i) pre-conference national Dr. M Manjula, Additional Professor, Ms. Lavanya, PhD Scholar, workshop on Promoting Mental Health through Positive Psychology, workshop on (i) Understanding Self, Counseling Centre, SSMRV UGC-sponsored National Seminar, MS University, Baroda, 3 March College, Bengaluru, 18 September 2015. 100 members participated 2016. 50 members participated (ii) national workshop on Positive (ii) Developing Resilience, Counseling Centre, SSMRV College, Psychology and Indian Psychology, Indian Psychology Institute, Bengaluru, 28 September 2015. 50 members participated. Pondicherry, 29 February 2016. 11 members participated.
National Institute of Mental Health and Neuro Sciences 97 Annual Report 2015-2016
Epidemiology Mental Health Education
Dr. Girish N, Additional Professor, Dr. Senthil Amudhan, Assistant Dr. KS Meena, Assistant Professor, Dr. Prasanthi Nattala, Associate Professor, (i) Training of ASHA and ANM on MNSUDs, Kolar, Professor of Nursing, Dr. Aruna Rose Kapanee, Assistant Professor Karnataka, 3- 27 November 2015. 978 Community Health Workers of Clinical Psychology, Dr. Mathew Varghese, Professor and Head (ASHAs/MPHW) participated (ii) National Symposium on of Psychiatry, Dr. Santhosh Loganathan, Associate Professor of Research Methodology for Multi-Centre Epidemiological Study in Psychiatry, interdepartmental symposium on Harnessing the Potential Cerebral Palsy, 10th IACP Conference 2015, Odisha, 19 December of Audio Visual Media for Mental Health Care, Bhopal, 21-24 2015. 300 members participated. January 2016. 10 members participated.
Neuroanaesthesia
Dr. M Radhakrishnan, Additional Professor, national workshop on Neuromonitoring, Neurovascon 2015, Ludhiana, 18 September 2015. 50 members participated
Dr. Sriganesh, Associate Professor, interdepartmental CME on Venous Thrombo-Embolism, Bengaluru, 20 September 2015. 135 Release of Asha training manual in Kolar members participated. Dr. Pradeep BS, Associate Professor, Dr. G Gururaj, Professor and Head, in collaboration with the Department of Youth Empowerment and Sports, Government of Karnataka (i) State Training of Yuva Neuro Imaging and Interventional Parivarthakas under Yuva Spandana, Bellary, 29 February- 4 March Radiology 2016. 41 members participated (ii) 1220 Sensitization programmes for youth in different districts of Karnataka – Project Yuva Spandana, Dr Rose Dawn Bharath, Associate Professor, Mr Rajanikant Panda, all over Karnataka, April 2015-March 2016. About 2,25,000 youths conducted Hands on workshop fMRI- Basic to Advanced Methods, participated. CMC, Vellore, 20-23 August 2015. 20 members participated.
Dr. Gautham MS, Assistant Professor, sensitization programme in NCDs and MNSUDs for Occupational Health Nurses and Neurological Rehabilitation Paramedics, Narasapura Industrial Region, Kolar, 2-3 December 2016. 15 staff members from various companies in Narasapura region Dr. Anupam Gupta, Additional Professor, national workshop on participated. Post Stroke Spasticity in Upper Limb, ISTART 2015, Mumbai, Maharashtra, 25-26 July 2015. 50 Psychiatrists & Neurologists participated.
Neurology
Dr. SR Chandra, Professor, (i) Neuroscience workshop on Survival Brain to Super Brain, Satya Sai Institute of Higher Medical Sciences, Puttaparthi, Andhra Pradesh, 11 April 2015. 100 members Training of industrial health staff at Honda participated (ii) national workshop on Approach to Patients with Dr. Senthil Amudhan, Assistant Professor, (i) training programme for Memory Complaint, API Kalaburagi Chapter, MR Medical College, school teachers on Cerebral Palsy & Epilepsy, Sarva Siksha Abhiyan, Kalaburagi, Karnataka, 28 June 2015. 500 members participated (iii) Kolar, Karnataka, 11 March 2016. 67 primary and secondary school Annual Psychiatry CME on Symptom Analysis in Neuropsychiatry, teachers of Kolar district participated (ii) training programme for Department of Psychiatry, KIMS Hubballi, 14 June 2015. 500 school teachers on Autism Spectrum Disorders & Epilepsy, Sarva members participated (iv) Annual CME on Perception-Normal Shiksha Abhiyan, Kolar District, 18 March 2016. 50 primary and and Abnormal, IAN, Agra, Uttar Pradesh, 1 October 2015. 2000 secondary school teachers of Kolar district participated. members participated (v) Case discussion on Spinal Cord Disorders,
98 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
MERT, API Karnataka Chapter, 30 October 2015. 2000 members Dr. TN Sathyaprabha, Professor, Dr. Om Latha Bhagat, Dr. KK participated (vi) Ageing and dementia, World Elders day celebration, Deepak, conducted APPI Pre conference workshop on Cardiovascular Senior Citizens association, Karnataka chapter, 14 November 2015. Autonomic Reactivity Tests, AIMS, Jodhpur, 25 November 2015. 70 200 members participated (vii) workshop on Parietal Lobe and members participated. Non-compressive Myelopathy, SHINE 2016, National Training Programme in Neurology and Neurosurgery for postgraduates in Dr. Laxmi T Rao, Additional Professor, Dr. Akshay Anand, Additional India, Chennai, 28 February 2016. 3000 members participated (viii) Professor of Neurology, PGIMER, Chandigarh, conducted CME on Investigations in Psychiatry –General Introduction to Panel Discussion, 33rd Annual conference of Indian Academy of EEG and its Role in Psychiatry, S. Nijalingappa Medical College Neurosciences, Gandhi Bhawan of Panjab University, Chandigarh, 31 and HSK Hospital and Research Centre, Navanagar, Bagalkot, 20 October-2 November 2015. 50 members participated. February 2016. 300 members participated (ix) Clinical CME on Ataxia- Case Discussion, Kasturba Medical College, Manipal, 17 Dr. Laxmi T Rao, Additional Professor, Dr. KN Narasimha Murthy, January 2016. 500 members participated (x) International Congress Adichunchanagiri Institute of Medical Sciences (AIMS), BG Nagar, on Child Neurology, Pyridoxine Dependent Convulsions among National CME on E=M4- Rediscovered Formula of Well-Being, Children with Refractory Seizures, Chennai, 22-24 January 2016. Mandya, Karnataka, 19 August 2015. 150 members participated. 2000 members participated Dr. Laxmi T Rao, Additional Professor, outreach programme on Dr. Chandra SR, Professor, Dr. Anita Mahadevan, Additional Healthy Brain is Healthy Life, Widia Poorna Prajna School, Peenya, Professor of Neuropathology, Dr. Thomas Gregor Issac, PhD Scholar, Bengaluru, 31 January 2016. 150 members participated. Dr. Krishnan Ayappan, Resident, Annual CME on Refractory Psychosis as the First Manifestation of Neuropsychiatric Lupus, IAN, Agra, Uttar Pradesh, 1 October 2015. 2000 members participated. Neurovirology
Dr. Ravi Vasanthapuram, Professor and Head, Dr. Reeta Mani, Associate Neuropathology Professor, national workshop and hands-on training in Good Laboratory Practices, Reporting and Quality Assurance in JE Testing, Assam Human Brain Tissue Repository (Human Brain Bank), NIMHANS Medical College And Hospital, Dibrugarh, Assam (as part of CDC, and Army Hospital (R&R) Delhi Cant., New Delhi conducted USA funded project entitled-Strengthening Surveillance for Japanese Neuroanatomy and Basic Neurophysiology Training Programme, 8th Encephalitis in India), 22-25 June 2015. 23 members participated. National Indian Brain Bee Championship, 9 May 2015. 12 members participated. Dr. V Ravi, Professor and Head, Early Career Mentorship National Workshop for Junior Faculty in Medical Microbiology, Annual Human Brain Tissue Repository (Human Brain Bank), NIMHANS Congress of Indian Association of Medical Microbiologists and Department of Molecular Reproduction, Development and (MICROCON 2015), JIPMER, Puducherry, 25 November 2015. 25 Genetics, IISc, organised Open Day and held exhibition of human members participated. brain specimens to bring awareness about brain in health and disease, IISc, Bengaluru, 4 March 2016. 5000 members participated. Psychiatry Dr. Anita Mahadevan, Additional Professor, 1stAnnual Conference of Neuropathology Society of India, NPSICON 2015, Hyderabad, 19- Dr. SK Chaturvedi, Professor, National IAPC Course Workshop on 20 December 2015. 160 members participated. Communication Skills, National Conference of Indian Association for Social Psychiatry 2015, Agra (a) 13-14 June. 45 members participated Neurophysiology (b) 14-15 December 2015. 40 members participated.
Dr. Bindu M Kutty, Professor, one-day faculty refreshment national Dr. Pratima Murthy, Professor, Wellcome Trust Funding Horizons workshop on Living Different: The Art and Science of Flourishing, National Workshop, Chennai, 12 February 2016. PESIT, 30 May 2015. 25 members participated. Dr. Naveen Kumar C, Associate Professor, conducted national Dr. TN Sathyaprabha, Professor, (i) national workshop on interdepartmental deliberations on Care Delivery (DECADE) Psychophysiology Relevant to Yoga Research, SVYASA, Bengaluru, for Mental Health in Rural Communities, Thirthalli, Shimoga, 12 19 March 2016. 60 members participated. December 2015. 120 members participated.
National Institute of Mental Health and Neuro Sciences 99 Annual Report 2015-2016
Psychiatric Rehabilitation (iii) Community Based Rehabilitation for the Disabled, Bijapur University, 6 December 2015. 60 members participated (iv) Sexuality among Adolescents with Disabilities, Fame India, 29 January 2016. Dr. T Sivakumar, Assistant Professor, Dr. Aarti Jagannathan, Assistant 15 members participated (v) Stress Management for the Employees Professor of Psychiatric Social Work, Dr. Avinash Waghmare, Senior of Revenue Department, Bangalore Urban and Rural, DC Office, Resident, national interdepartmental symposium on Caregiver 4 March 2016. 40 members participated (vi) Mental Illness and Educational and Support Groups: NIMHANS Initiatives and Disability, Bengaluru, 31 March 2016. 42 members participated. Experiences, National Conference of Indian Association for Social Psychiatry 2015, Agra, 6-8 November 2015. 15 members participated. Dr. C Jaya Kumar, Assistant Professor, national workshop on Psychosocial Care in Disaster Management, Civil Defense College, Dr. T Sivakumar, Assistant Professor, Dr. Krishna Prasad M, Associate Nagpur, 5 February 2016. 27 members participated. Professor, Dr. Dheeraj Kattula, Assistant Professor of Psychiatry, CMC, Vellore, Dr. AK Agarwal, Professor and Head of Psychiatry, Dr. Kavita Jangam, Assistant Professor, Dr. Shekhar P Seshadri, King George’s Medical University, Lucknow, National Symposium Professor of Child and Adolescent Psychiatry, sensitization workshop on Daycare as Rehabilitation Tool in Psychiatry, Annual National on Psycho-Social Issues of Sportsperson and Coaches/Officials, Conference of Indian Psychiatric Society, Bhopal, 24 January 2016. Sports Authority of India, Bengaluru, 15-16 September 2015. 200 15 members participated members participated.
Psychiatric Social Work Dr. E Aravind Raj, Assistant Professor, workshop on (i) Harmonizing Personal, Professional and Familial Life, Cipla Pharmaceuticals, Bengaluru, 28 May 2015. 45 members participated (ii) Stress Dr. K Sekar, Professor and Head, (i) Colloquium on Children in conflict Management, Accenture, Bengaluru, 18 June 2015. 100 members with law in Kerala, Trivandrum, 25 November 15 (ii) Workshop on participated (iii) Life Skills Education Program, Directorate of Psychosocial Care in Disaster Management, Department of Social Higher Secondary Education, Government of Kerala, Kozhikode, Work, Amrita Vishwa Vidyapaeetham Ettimadai, Coimbatore, 21-25 27-31 July 2015. 40 members participated (iv) Life Skills Education March 2016 (iii) TOT on Life Skill for teachers/faculty of Women’s Program, Directorate of Higher Secondary Education, Government University, Sri Padmavathi Mahila Vishwa Vidhyalayam, Tirupathi, of Kerala, Thiruvananthapuram, 3-7 August 2015. 40 members 28 March 16 participated (v) Life Skills Program, SEESHA Transformation Center, Coimbatore, 7-8 August 2015. 40 members participated (vi) Dr. D Muralidhar, Professor, workshop on (i) Mental Illness and Stigma Psychosocial Interventions for Persons with Mental Illness, Iswar Reduction Strategies, Dept. of Psychiatric Social Work , RINPAS, Sankalpa, Kolkata, 2-5 September 2015. 40 members participated (vii) Ranchi, 3 September 2015 (ii) Teaching Methodologies for mental Care for Caregivers, Iswar Sankalpa, Kolkata, 23-24 September 2015. health professionals, Dept. of Psychiatric Social Work, RINPAS, 40 members participated (viii) Mental Health, Action Aid India, Ranchi, 5 September 2015 (iii) Skills in Research Methodology for Srinagar, 28 September - 8 October 2015. 10 members participated post-graduate and doctoral students, Sri Padmavathi Mahila Viswa (ix) Psychosocial Care in Disaster Management, NIDM, New Delhi, Vidyalaya, Tirupathi, 9 October 2015 (iii) Practice of Counselling 26- 30 October 2015. 28 members participated (x) Psychosocial Care in Traditional and Modern India, Sri Padmvathi Mahila Viswa in Disaster Management, Department of Social Work, Pondicherry Vidyalaya, Tirupathi, 7 October 2015 (iv) Practice of Life Skills for University, 25 November 2015. 41 members participated (xi) Teachers Social Workers, Sri Padmvathi Mahila Viswa Vidyalaya, Tirupathi, 5 on Psychosocial Care in Disaster Management, Stella Maris College, October 2015 (iv) Group Therapy in Mental Health Setting, Dept. of Chennai, 10 December 2015. 35 members participated (xii) Statistics Psychiatry, CIP, Ranchi, 3 November 2015. in Social Work Research, Christ University, 22 December 2015. 40 members participated (xiii) School Mental Health for Volunteers of Dr. Md. Ameer Hamza, Additional Professor, Dr. Priya Treesa Corporate Sector- A CSR Initiative, Sanseera Engineering private Thomas, Assistant Professor, Mr. G Ragesh, PhD Scholar, Ms. Sajitha limited, 5-7 January 2016. 21 members participated (xiv) Counselling K, Psychiatric Social Worker, workshop on Common Mental Illness Skills for Teachers, Manipal University, Manipal, 8-10 January for legal professionals, Bengaluru, 20 August 2015. 53 members 2016. 20 members participated (xv) Psychosocial Competence for participated. Rural Schoolchildren, Sansera Engineering Pvt. Ltd, Bangalore, 22 January 2016. 19 members participated (xvi) Psychosocial Care in Dr. N Janardhana, Associate Professor, workshop on (i) Community- Disaster Management, Mahatma Gandhi State Institute of Public based Rehabilitation, Mobility India, Bengaluru, 24 May 2015 (ii) Administration, Chandigarh and NIDM, New Delhi, 14-18 March Psychosocial Wellbeing for the employees retiring from HPCL, 2016. 21 members participated. HPCL, Bengaluru, 7 September 2015. 40 members participated
100 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Psychopharmacology Dr. Meera SS, Speech Therapist, (i) programme on Speech-Language and Communication Needs for Children with Developmental Disabilities, for the Commanding Officer and Head of the ASHA Dr Chittaranjan Andrade, Professor and Head, (i) workshop on Special School, affiliated to the Armed Forces, Jabalpur, Bengaluru, 18- (a) Management of Chronic Schizophrenia, Indian Psychiatric 19 March 2016. 15 members participated (ii) Assessments of Speech- Society, Bangalore, 25 April 2015. 100 members participated (b) Language Disorders for Children with Developmental Disorders, Treatment Options in Chronic Schizophrenia, Indian Psychiatric Latika Roy Foundation, Dehradun, Bengaluru, 23 September 2016. Society, Madurai, 30 May 2015. 100 members participated (c) 50 members participated. Psychopharmacology of Chronic Schizophrenia, Calicut Psychiatrists’ Guild, Calicut, 6 June 2015. 100 members participated (d) Current Treatments in Schizophrenia, Guntur Psychiatric Society, Guntur, 27 June 2015. 100 members participated (e) Psychopharmacology of NIMHANS Centre for Well Being Schizophrenia: Update, Chandigarh Psychiatric Society, Chandigarh, (NCWB) 25 July 2015. 100 members participated (f ) Measures of Effect Size and 95% Confidence Intervals in Research, State Board of Medical Smt. D Padmavathy, Staff Nurse and Project Staff, Health Education Research, Government of Kerala, Trivandrum, 4 September 2015. Programme on (i) Postpartum Psychosis, 9 April 2015. 42 members 100 members participated (g) Understanding Meta-Analysis, State participated (ii) Prevention of Breast Cancer, 23 April 2015. 50 Board of Medical Research, Government of Kerala, Trivandrum, members participated (iii) Swine Flu, 7 May 2015. 42 members 5 September 2015. 100 members participated (h) How to Write a participated (iv) How to Quit Tobacco, 11 June 2015. 32 members Research Paper, State Board of Medical Research, Government of participated (v) Healthy Food Habits, 25 June 2015. 27 children of Kerala, Trivandrum, 5 September 2015 (i) SPARI Antidepressants, Tavarekere Anganwadi participated (vi) Handwashing, 30 July 2015. Indian Psychiatric Society, Jaipur, 16 September 2015. 100 63 children participated (vii) Return Demonstration of Handwashing members participated (j) Depression and its Treatment: Update, Procedure, by Tavarekere Anganwadi children, 6 August 2015. 65 Indian Association of Private Psychiatry, Gujarat, Ahmedabad, 18 children participated. September 2015. 100 members participated (k) Depression and its Management, Indian Psychiatric Society, Bihar, Patna, 16 October Smt. D Padmavathy, Staff Nurse, Ms Taranum Taj, Assistant 2015. 100 members participated (l) Antidepressants for Clinical Coordinator, Health Talk on (i) Post-Natal Depression, Practice, Delhi Psychiatric Society, Delhi, 17 October 2015. 100 Tavarekere PHC, 5 November 2015. 47 members participated (ii) members participated (m) Psychopharmacology and Cognitive Breast Self-Examination, Tavarekere PHC,19 November 2016. Therapy in Psychiatric Practice, Melmaruvathur Adhi Parasakthi 47 members participated (iii) Healthy Food Habits, Tavarekere Institute of Medical Sciences and Research, Melmaruvathur, 29 Anganwadi, 17 December 2016. 40 children participated (iv) October 2015. 100 members participated members participated (n) Post Natal Psychosis, Tavarekere PHC, 14 January 2016. 52 Intranasal Ketamine in Depression, Bombay Psychiatric Society, members participated. Thane, Bombay, 13 February 2016. 100 members participated (ii) CME on (a) Treatment of Psychosis, Manas Foundation, Ludhiana, 26 July 2015. 100 members participated (b) CME on Dealing with Newer Antidepressants, Indian Psychiatric Society, West Bengal, SPECIFIC TRAINING UNDERWENT Calcutta, 1 November 2015 (c) CME on Intranasal Treatments in BY FACULTY/STAFF Neuropsychiatry, DY Patil University, New Bombay, 13 February 2016. 100 members participated. Clinical Neurosciences
Speech Pathology & Audiology Dr. Velmurugan Jayabal, Resident, one-week Clinical Magnetoencephalography (MEG) training, Overlook Medical Dr. Vandana VP, Assistant Professor, (i) interdepartmental seminar Center, New Jersey, USA, August 2015. on Inspire to Aspire: An Interaction with the Stakeholders of Autism at Work, SAP Labs and Enable India, Bengaluru, 3 August 2015. Dr. Kiran Polavarapu, Resident, underwent two-day training in 25 members participated (ii) interdepartmental expert meeting Application of NGS in Clinical Diagnostics, Dhiti Omics, Bengaluru, on Indigenous AAC Technology, on the prototypes developed (a) 4-5 December 2015. KAVI-PTS (b) ADITI, Mindtree, Bengaluru, 17 December 2015. 7 members participated. Dr. Ragasudha Botta, Resident, three- day training, International Parkinson and Movement Disorder Society- Asia Oceania Section
National Institute of Mental Health and Neuro Sciences 101 Annual Report 2015-2016
nd (M DS-AOS) Course, 2 Middle East Camp for Parkinson’s, Neuropathology Movement Disorders and Neuromodulation, Dubai, UAE, 19-21 November 2015. Dr. Gayathri N, Professor, two-day training in Laboratory Quality Management Systems & Internal Audit as per ISO 15189-2012, Foundation for Quality (India), 16-17 May 2015. Clinical Psychology Dr. Yasha TC, Professor, Dr. Anita Mahadevan, Additional Professor, Dr. LN Suman, Professor, four-day Basic Training (Part I) in EMDR two-day training in Laboratory quality management systems & Technique, Indian Social Institute, Bengaluru, 18-21 June 2015. internal audit as per ISO 15189-2012, Foundation for Quality (India), 27-28 August 2015. Dr. Devvarta Kumar, Associate Professor, six-month training programme, Liverpool-India Fellowship, Institute of Health and Mr. Suresh Parmar, Scientist ‘B’, five-day training at 1st International Psychology, University of Liverpool, Liverpool, 23 September 2015 3D Neuroanatomical Workshop- Fiber Track Dissection Technique, – 16 March 2016. ICMR-DHR Project, Jaipur, 28 October- 1 November 2015.
Dr. M Thomas Kishore, Professor, six-day training in workshop on Developmental Assessment Scales for Indian Infants and Follow-Up Neurovirology of High Risk Newborns and Neurodevelopmental Tests, Department of Pediatrics and TDH Morris Child Development Centre, KEM Dr. Anita Desai, Professor, Dr. R Vijayalakshmi, Post-Doctoral Hospital, Pune, 1-6 June 2015. Associate, training in CDC, Fort Collins, Colorado, USA, 14-25 September 2015. Dr. Veena Satyanarayana, Assistant Professor, (i) five-day EMDR Training, Indian Social Institute, Bengaluru, 18-21 June 2015 (ii) three-day training in Framework Analysis (NVivo), Dhaka, Transfusion Medicine & Bangladesh, 17-19 February 2016. Haematology
Dr. Sangeetha Seshagiri K, Clinical Pathologist- Specialist Grade, Neuroanaesthesia two-day training in Internal Audit and Quality Management System- Refresher Course as per ISO: 15189 2012, Foundation of Quality Dr. M Radhakrishnan, Additional Professor, (i) two-day training in (India), Anand Diagnostic Laboratory, Bengaluru, 26-27 November Intraoperative Neurophysiology Workshop, ASNACC Conference, 2015. South Korea, 3-4 April 2015 (ii) Observership, National University Hospital, Busan, South Korea, 5-11 April 2015. College of Nursing
Neurochemistry Dr. C Rajeswari, Lecturer, two-day 12th MDRF-UAB-FIU Intensive Interactive Training Program on Clinical Research Methods, Madras Ms. Archana Natarajan, Jr. Research Fellow, Ms. Roopa, Junior diabetes Research Foundation, Chennai, 6-7 February 2016. Technician, Mr. Harish, Junior Technician, one-day training in mass spectrometry, Waters India (Pvt) Ltd, Bengaluru, 2 March 2016. Mrs. A Shamala, Clinical Instructor, Mrs. Annie John, Clinical Instructor, seven-day training programme for National Social Service Programme Officers, Mysore, 10-16 July 2015. Neurology
Dr. Sanjib Sinha, Professor, five-day MEG Training Programme, Overlook Hospital, New Jersey, USA, 30 August- 3 September 2015.
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Activities of Dr. Ramachandra N Moorthy Foundation for Mental Health and Neurological Sciences Dr. Ramachandra N Moorthy Foundation for Mental Health and 2. Symposium on Nuts and Bolts of Starting and Running Neurological Sciences, established to promote training and academic Psychiatric Rehabilitation Services (April 2015). activities in the field of mental health in India, funded 33 training, 3. Symposium to enable the professional social workers to update capacity building and other vital educational activities/programme, their knowledge and skills in the areas of clinical social work during the year 2015-2016, practices in mental health, July 2015. 4. Learning from best practices in disability sector: Implications Training and capacity building for Psychiatric Rehabilitation, September 2015. 1. Workshop to assess and manage medically unexplained 5. An unconference on perinatal psychiatry by the next generation symptoms (MUS), May 2015. of Indian mental health professionals’ activity October 2015. 2. Caregivers Support & Education Programme, Psychiatric 6. Integrating Scientific and Contemplative Approaches to Rehabilitation Services (May 2015 to March 2016). Explore the Mind, a one day conference (December 2015). 3. Workshop on Team Building in Nursing: Bridges to the Future, 7. Symposium on Child Mental Health in India: Catalysing the September 2015. public health response ( January 2016) 4. One day capacity building workshop on psychological 8. Symposium on Quality of Life in Chronic Mental Illnesses: approaches to addictive behaviours November 2015. Exploring New Frontiers ( January 2016). 5. Workshop to educate patients and family members about the 9. How to start and run psychiatric rehabilitation services in medical basis of mental illness and its management. October various setups like OPD, inpatient, stay facilities, community? 2015. A one day symposium 6. Promoting Dignity through Cognizance of Medical Facts associated with Mental Illness, October 2015. IEC materials 7. A one-day conference titled Deliberations on Care Delivery 1. Printing and publishing ‘The Loudspeaker’ mental health (DECADE) for Mental Illness in Rural Communities, magazine for general public, NIMHANS Centre for Well Thirthahalli, Shimoga (12 December 2015). Being. 8. Fourth Early Career Mental Health Professionals Workshop by 2. Printing of booklets on Social Skills Training for teachers. Prof. Norman Sartorius and Dr. Mohan Isaac ( January 2016). 3. Developing videos and educational materials on maternal 9. Transforming Care at Bedside (T-CAB) for patient care and mental health for skill building among healthcare professionals vitality of healthcare team ( January 2016). caring for women during her childbearing period. 10. Solution focused brief therapy (February 2016). 4. Promoting internet-based e Health programme 11. Practical tips and hands on training on different aspects of 5. Information, Education and Communication (IEC) materials scientific publication (March 2016). related to preventive and promotive aspects of mental health 12. Training medical officers in mental health, at Anekal taluk, 6. Dissemination of neuro-psychiatric information, education and Bengaluru (February & March 2016). communication material to related public. 13. Workshop on Psychosocial Issues and Role of Nurse in Child Adoption (March 2016). Dr. Ramachandra N Moorthy Foundation for Mental Health 14. Dance/Movement & Drama Therapy: Creative mental health and Neurological Sciences at NIMHANS was created through a approaches to growth and healing (March 2016). generous donation by Dr. Ramachandra N Moorthy, an Indian-born 15. Orientation programme for nurses on Psychiatric Rehabilitation Psychiatrist in Vancouver, Canada. The total donation was about Services (March 2016). Rs. 3.35 crore, and it has been decided to use the annual interests 16. Trainer workshop on Technology Addiction for NIMHANS generated (of about Rs. 30 lakh) for various academic activities. trainees. 17. Workshop on educating college students about harmful effects of tobacco use and how to quit, as well as to empower them to disseminate the knowledge and skills learnt, and help harmful users to quit tobacco. 18. Capacity building for NGOs staff to acquire essential skills in the management of rehabilitated persons with mental illness.
Conferences/Symposia 1. Symposium to critically evaluate the current status of the The Fourth Leadership and Professional Skills Workshop for Early Career neuroscience research on music and meditation to understand Psychiatrists saw participants from Sri Lanka, Nepal and Bangladesh (SAARC countries), and from various parts of India. cognition and consciousness.
National Institute of Mental Health and Neuro Sciences 103 Central Facilities
Neurobiology Research Awards and Publications Total Laboratory Awards Centre (NRC) Publications Translational Psychiatry Laboratory 4 25 Neurobiology Research Center (NRC), one of the most sophisticated Multi-modal Brain Image Analysis Laboratory 5 8 common research facilities, provides a platform to promote Advanced Flow Cytometry Laboratory - 1 interdisciplinary collaborative research at NIMHANS. The Metabolic Laboratory 5 22 centre provides infrastructure to support translational research Neuro-Oncology Lab - 11 and development of cutting-edge technology in frontier areas of Molecular Genetics Laboratory - - neuroscience. NRC houses 15 research laboratories and four central Bioinformatics Laboratory 1 10 facilities. Most of the laboratories continue to receive extramural grants Cell Culture and Stem Cell Biology 3 3 for their research work from DBT, DST, ICMR, CSIR among others. Electrophysiology Laboratory 5 6 During the year 2015-16, a total of 79 projects were funded by these Optical Imaging Lab - 2 funding agencies to the different research laboratories. The mandate Neuromuscular laboratory 1 8 of NRC is that all the central facilities and research laboratories are Neurotoxicology laboratory 1 2 common facilities, to be shared and used by scientists, research scholars Cognitive Psychology & Cognitive 3 3 and students at NIMHANS. There has been an increase in the number Neurosciences Laboratory of students/researchers using this facility in 2015-2016, compared to Total 28 101 the previous year (178 in 2015-16 against 171 in 2014-15). A total of 88 students and two faculty members from outside institutions also used the facilities extended by various research laboratories of the centre. Common Facilities
Research projects Human Brain Tissue repository (Human Brain Bank; Funded projects Non-funded Faculty In-charge: Dr. SK Shankar) Laboratory Com- On Com- On pleted going pleted going The Brain Bank has actively continued its mandate of (a) collection Translational Psychiatry Laboratory - 8 - 2 of donated brains from cases of neurodegenerative and infective Multi-modal Brain Image Analysis 4 4 - - conditions (b) collection of brains from victims of road traffic Laboratory accidents (RTA) as relatively normal controls (c) distribution of the Advanced Flow Cytometry Laboratory - 4 1 3 brain tissue, CSF and serum to research to scientists from all over the Metabolic Laboratory 3 9 1 9 country. The brain specimens and CSF/serum have been collected Neuro-Oncology Laboratory 2 3 5 4 following written informed consent from close relatives. During Molecular Biology Laboratories- 1 1 1 2 the review period, 11 fresh brains were collected from cases of RTA Communicable and Non- and diseased states including stroke, CNS infections encompassing Communicable HIV and neuropsychiatric disorders. A total of 148 blood samples Cell Culture and Stem Cell Biology 1 3 1 3 were collected and stored for DNA studies. In addition, 36 fresh Electrophysiology Laboratory 4 5 4 8 brain biopsy samples following epilepsy surgeries were collected Optical Imaging Laboratory 1 4 2 6 and stored. These samples were stored at -86oC. Apart from this, Molecular Genetics Laboratory 2 2 6 7 30 cadaver hearts from RTA victims were collected and provided Bioinformatics Laboratory 8 4 10 22 for homograft transplantation to Jayadeva Institute of Cardiology Neuromuscular Laboratory 2 3 2 5 and Research Centre, Manipal Hospital and Narayana Hrudayalaya, Neurotoxicology Laboratory - 3 - 2 Bangalore. Required brain tissues from various anatomical areas, Cognitive Psychology & Cognitive - - 1 2 CSF samples from normal controls and diseased states were Neurosciences Laboratory distributed to 24 scientists/PhD scholars throughout India for their Total 27 52 33 73 research work.
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many foreign scientists and clinicians, who came to NIMHANS for scientific collaboration, visited the Brain Museum and greatly appreciated the unique collection and the means of display. The Brain Museum was also widely reported in print and electronic media. The total number of visitors to the Neuropathology Brain Museum was 5300 during 2015-2016 in contrast to 4184 during the year (2014-2015). The visitor footfall has been increasing every year owing to the wide dissemination of information about the facility in the print, electronic and social media. The staff of Human Brain Bank regularly conducts guided tour for the visitors explaining the nature and importance of the exhibited specimens including the human brain, spinal cord and other organs. The museum permits the visitors to touch and feel the organs, providing unique experience to them. The museum has prepared/distributed/ donated nearly 41 posters (3ft X 3ft) as a public awareness initiative and these are being used regularly in the local exhibitions organized by schools/colleges and Indian Epilepsy Association. To accommodate the increasing number of specimens, the museum is being expanded. The co-ordinator of the Brain Bank has been conducting classes in Neuroanatomy and Neuropathology as a part of the Ph.D. Neuroscience module and to the DM/M.Ch./MD Pathology students posted in Department of Neuropathology.
Students from Edify School and Christ University during their visit to the New facilities/initiatives Human Brain Bank • LED lights have been installed at the Neuropathology Brain Museum to reduce power consumption and make it environmental friendly. Human Brain Bank is actively involved in the promotion of neuroscience and public awareness programmes about cadaver organ • Sorting of fresh brain samples completed and digitalization donation and brain donation. This has led to an increase in the of Human Brain Bank have been started for the management number of donors who pledge their brain for research after death— of sample inventory with the procurement of bar code printer, five citizens registered as donors this year. Families of eight individuals scanner and labels. donated their brains after death for research purposes.
• CCTV cameras have been installed in the Human Brain To promote public awareness and education amongst Museum for specimen safety and general surveillance. schoolchildren, six outreach programs were conducted in schools and colleges, where more than 16,000 students enthusiastically • Mulligan and Ashton’s brain slice staining techniques have been participated to gain knowledge about the human brain and brain employed to differentiate grey from white matter to enhance disorders. teaching experience.
Neuropathology Brain Museum (Dept. of Neuropathology; • Brain fibre dissection technique incorporated with tractography Head: Dr. Vani Santosh; Faculty In-charge-Prof. SK co-relation has been initiated in collaboration with Dept. Shankar) of Neurosurgery, NIMHANS. Dissected specimens are photographed and mounted and are displayed in the museum. The Neuropathology Brain Museum (Human Brain Museum) is the only one of its kind in the country. This unique facility has Central facility for Millipore Water Purification system, become a centre of attraction for the students of various colleges Liquid nitrogen and Waste Disposal and schools and the tourists alike to have a look at the diverse collection of specimens/samples of human brains and other vital The high capacity Millipore (ELIX 70 Ltr/hr and Synergy) water organs. During 2015-2016, students from 36 schools and 48 purification system provides more than 2000 litres/month of purified colleges (3266 students) visited the Brain Museum. In addition, water used for multiple laboratory and hospital applications including
National Institute of Mental Health and Neuro Sciences 105 Annual Report 2015-2016 ultrapure water required for molecular biology research. The NRC & advanced computational research techniques to examine the is also provided with a dedicated central waste disposal facility in “Neuroimmunopathogenetic Model for Schizophrenia”. the ground floor which is equipped with a large volume autoclave and a shredder for hospital / lab waste disposal. The liquid nitrogen Completed research activities:
(LN2) storage tank of capacity 900 litres is a source of supply for Research activities completed during the year 2015-2016 include liquid nitrogen which is being used regularly by several laboratories studies on immuno-genetic and neuroplasticity correlates white at NRC and other laboratories in the administrative block such as matter abnormalities in schizophrenia, relationship between glutamate Departments of Neurovirology, Neuropathology, Neurochemistry, levels as assessed by magnetic resonance spectroscopy and mismatch Neurophysiology and Biophysics. negativity in schizophrenia, genetic and eye tracking correlates of the effect of transcranial Direct Current Stimulation (tDCS) in ICMR Centre for Advanced Research for Innovation in schizophrenia and pilot studies on tDCS in OCD. Mental Health and Neurosciences Ongoing research activities: Ongoing projects include: Ongoing research activities focus on examining the 1. Development of Neuroscience Educational Materials for neuroimmunogenetic and neuroplastic correlates of brain popularizing Neuroscience under Human Brain Bank (In abnormalities in schizophrenia, neuromodulatory effects of tDCS keeping with the mandate of developing Neuroscience in schizophrenia, eye movement abnormalities in schizophrenia Educational Material, a Histological Atlas of the Common and OCD, EEG/ERP abnormalities in schizophrenia and OCD, Infections of the CNS, along with a set of histological slides, neurohemodynamic abnormalities in schizophrenia using functional depicting the pathological features and a CD containing the Text Near Infrared Spectroscopy and imaging-genetics studies in OCD. and Photographs in the Atlas has been prepared. During year 51 histological sets and more than 320 booklets with CDs are Patient care services: distributed among the medical colleges and pathology residents.) TransPsych Lab facilitates provision of transcranial direct current stimulation for schizophrenia patients, OCD and several other 2. Translational Research in Amyotrophic Lateral Sclerosis (ALS) psychiatric disorders. Research staff in the lab contributes to the – Development of Biomarkers for diagnosis, monitoring disease clinical services of the schizophrenia clinic as well as the metabolic progression and evaluation of toxicity. clinic.
3. Development of ELISA and evaluation of the potential of 14- Multi-modal Brain Image Analysis Laboratory (Faculty In- 3-3 protein as a biomarker of neural injury / Neurodegeneration charge: Prof. John P. John) with special reference to Creutzfeldt –Jakob disease. This laboratory aims at integrating the acquisition and analysis of multiple modalities of brain imaging for a more comprehensive Research Laboratories understanding of brain structure, function and signalling in various neuropsychiatric disorders. This facility aims at employing an Translational Psychiatry Laboratory (Faculty In-charge: integrated multi-disciplinary approach to examine brain structure and Prof. G Venkatasubramanian) function in health and disease through active collaborations between various departments both within and outside the institute. Research projects being undertaken at MBIAL include multi-modal imaging- The Translational Psychiatry Laboratory (TransPsych Lab) facilities genomics studies in schizophrenia and dementia, as well as of certain have been created towards initiation of an integrated clinical research cognitive processes; these projects are funded by the Department of facility with focus on translational applications in psychiatry. This Science and Technology (DST) and Department of Biotechnology research facility is supported by research grants from Welcome (DBT). Many PhD scholars, MD (Psychiatry) post-graduates as well Trust / DBT India Alliance Senior Fellowship Award as well as as trainees from other departments of NIMHANS as well as external from the Department of Biotechnology. The goal of the TransPsych trainees have also utilized the facility for obtaining training in various Lab is to evaluate and establish composite biomarkers involving aspects of multi-modal image acquisition and analysis. neuroimmunobiological abnormalities in Schizophrenia and other disorders like Obsessive Compulsive Disorder, Bipolar Affective Completed research activities: Disorder and Alzheimer’s disease. The vision of this centre is to create During 2015-16, the following DST-funded collaborative projects an international calibre translational research facility integrating were completed: (i) A Multimodal Imaging-Genomics Approach clinical, neuroimmunological, neuropathological, neuroimaging to Investigating the Link between Impaired Word Generation and
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Aberrant Glutamatergic Function in Schizophrenia; (ii) Network Ongoing research activities: Connectivity in Elderly with Minimal Cognitive Impairment or (i) Immune Signatures of Responses to Dengue Virus Infection Early Dementia – a functional MRI study; (iii) Default Mode (Indo-US DBT-NIH funded Vaccine Action Program Grant, Network and Cognition in Healthy Ageing; (iv) Neural Correlates collaboration between Department of Neurovirology, NIMHANS of Well-being Associated with Mindfulness Meditation: A Neuro- and Yale University, USA); (ii) Role of immune dysregulation in post- psychophysiological and Neuro-imaging Study. The imaging partum psychosis (NIMHANS Intramural Research Grant); (iii) components of the above projects were carried out at MBIAL. T-cell responses in Japanese encephalitis and original antigenic sin (part of dual PhD program between Department of Neurovirology, Ongoing research activities: NIMHANS and University of Liverpool, UK); (iv) Study on The lab is involved in the neuroimaging/electrophysiology core of Vitamin D and its association with immune function in Autism the recently initiated multi-institutional DBT-funded project titled Spectrum Disorder (Department of Psychiatry); (v) Immunobiology “Accelerator program for Discovery in Brain disorders using Stem cells of Neuromyelitis Optica (Department of Neurology); (vi) RNA (ADBS). Some of the other major thrust areas of research at MBIAL interference mediated downregulation of human telomerase reverse include: (i) Utilizing multi-modal imaging methods in conjunction with transcriptase (hTERT) in LN18 cells (Department of Human molecular genetics, neurochemical and neurophysiological approaches Genetics); (vii) Immune abnormalities in Schizophrenia (Department to investigate the neurobiology of schizophrenia, dementia as well as of Neuromicrobiology) consciousness (meditation as well as aberrations of consciousness in psychiatric disorders) in collaboration with researchers from Geriatric Metabolic Laboratory (Faculty In-charge: Prof. Rita Clinic and Services, Molecular Genetics Laboratory, as well as Christopher) departments of Neurophysiology and Neurochemistry; (ii) Resting and task-based functional connectivity analyses in mild cognitive The focus of this laboratory is to provide diagnostic services for the impairment and dementia; (iii) Mathematical modelling of gene- identification of neurometabolic disorders and to carry out translational gene and protein-protein interactions affecting brain morphometry in research in neurometabolic and cerebrovascular disorders. In a 3-mm schizophrenia in collaboration with faculty from Molecular Genetics spot of blood collected on filter paper, 10 amino acids, free carnitine Laboratory, NIMHANS and Department of Computational and and 30 acylcarnitines are measured using a triple quadrupole liquid Data Sciences, Indian Institute of Sciences; (iv) Brain functional chromatography-mass spectrometer, and based on the characteristic connectivity underlying conscious awareness and its aberrations profiles, inborn errors of amino acid metabolism, fatty acid oxidation in schizophrenia, in collaboration with the Consciousness Studies defects and organic acidemias are identified. This facility, which is the Programme at National Institute of Advanced Sciences (NIAS), first of its kind in a government set-up in the country, attracts samples Bengaluru; (v) Machine learning approaches using multimodal from all over India as well as from other neighbouring countries. neuroimaging metrics in schizophrenia in collaboration with Indian Since 2008, the lab has been participating and obtaining 100 percent Statistical Institute, Bangalore; (vi) Study of the neural correlates of satisfactory results for amino acid and acylcarnitine testing in the prospective memory, an important brain function mediated by the Newborn Screening Quality Assurance Program, conducted by the rostral prefrontal cortex; (vii) Development of computerized cognitive Center for Disease Control and Prevention (CDC), Atlanta, USA. intervention programs in collaboration with departments of Clinical Psychology and Department of Speech Pathology and Audiology. Completed research activities: During the year under review, studies were conducted to identify a Advanced Flow Cytometry Laboratory (Officer In-charge: microRNA signature in the plasma of patients with cerebral small Prof. Ravi V) vessel disease which could serve as a molecular biomarker of this disease. This work has been selected for the award of “Centre of The flow cytometry lab is equipped with an advanced four laser Excellence in Science Engineering and Medicine-2014-15” by the BD FACS Aria III cell sorter and a three laser FACS Verse Vision Group on Science and Technology, Government of Karnataka. analyzer, which enable sorting and analysis of single cells based on multiple parameters respectively. Students/researchers from several In the previous year, a high-throughput, multiplexed, mass departments at NIMHANS use this machine for their research work spectrometry-based method was established for the simultaneous under the supervision of a Senior Scientific Officer. estimation of 5 lysosomal enzymes in 3mm-dried blood spots for the identification of Gaucher, Pompe, Niemann-Pick type A and B, Completed research activities: Krabbe and Fabry diseases. The reference ranges of these enzymes in Project on comparative study of innate and cell mediated immune blood spots were established for the Indian population. The role of responses in human-immunodeficiency virus infected individuals with various pre-analytical factors which can affect enzyme activity and and without neuro-tuberculosis was completed. result in false positive results was determined. Blood spots from 9105
National Institute of Mental Health and Neuro Sciences 107 Annual Report 2015-2016 new-borns and 4703 symptomatic patients were tested to determine in Glioblastoma and its effect on glioblastoma pathogenesis; (iii) the prevalence of these disorders in the Indian population. A cost- Molecular profiling of Gliosarcoma; (iv) Prognostic relevance of benefit analysis for conducting new-born screening for these disorders clinically relevant genetic and epigenetic molecular biomarkers in was carried out. glioblastoma; (v) Molecular alterations in paediatric glioblastoma.
A study to determine the role of vitamin D status and vitamin D Molecular Biology Laboratories — Communicable and receptor gene variants on vascular risk in patients with ischemic stroke Non-communicable (Faculty In-charge: Prof. Ravi V) was completed. The Molecular Biology labs (Communicable and Non- Ongoing research activities: Communicable Disease labs) are being used routinely by students Presently, studies are being conducted to identify differentially from various departments at NIMHANS namely Human expressed microRNAs in the plasma and ruptured aneurysm tissue Genetics, Molecular Genetics, Biophysics, Bioinformatics, of patients with aneurysmal subarachnoid haemorrhage to determine Neuropathology, Neurochemistry, Neurovirology, Neurophysiology, their utility as diagnostic biomarkers and to elucidate their possible role Neuromicrobiology, etc. either for performing Real Time PCR in the formation and rupture of intracranial aneurysms. The possible / Conventional PCR assays or for analysis of gels / blots on the role of estradiol and estrogen receptors in the patho-mechanism of chemiluminescence enabled Gel Documentation system. Two rooms cerebral aneurysm rupture is also being explored in this facility are being used for Cell culture work by the Molecular Genetics Lab. A study to determine whether vitamin D insufficiency is associated with increased risk for severe vascular cognitive impairment in the Completed research activities: elderly, establish whether the gene variants of the vitamin D metabolic Immune responses in patients with mild, moderate and severe pathway could predict the risk for cognitive decline and elucidate the infection by influenza virus (H1N1) infection. possible mechanism by which low vitamin D status could increase risk for vascular cognitive impairment, is being carried out. Ongoing research activities: Faculty and students in the two laboratories are carrying out a Several collaborative projects with the faculty of the Institute and of comparative study of innate and Cell Mediated Immune Responses Jayadeva Institute of Cardiovascular Sciences and Research, are also in Human Immunodeficiency virus infected individuals with and being conducted. without Neurotuberculosis, studying the molecular aspects of the pandemic Influenza A 2009 (H1N1) virus with special reference to Patient care services: host immune factors, offering molecular diagnosis for Dengue and 5400 samples were screened for IEM using tandem mass spectrometry. studying the epidemiology of Dengue virus and immune signatures during responses to dengue virus infection. Neuro-Oncology Lab (Faculty In charge: Prof. Vani Santosh) Molecular Genetics Laboratory (Faculty In-charge: Prof. The Neuro-Oncology Lab was established in September 2011 with a Sanjeev Jain) prime objective of translational research in Neuro-Oncology. The lab focusses on tissue based research along with collaborations with core Molecular genetics laboratory carries out research projects and biological research institutes. This has paved way in understanding diagnostic work in neuropsychiatric conditions (schizophrenia, the pathogenesis of several adult and pediatric brain tumors with bipolar affective disorder, obsessive compulsive disorder, dementia, emphasis on gliomas, medulloblastomas and meningiomas. Huntington’s disease, spino-cerebellar ataxia, Duchene’s/Beckers muscular dystrophy and spino-muscular atrophy). Till date over 15000 Completed research activities: DNA samples from neuropsychiatric conditions and 1050 control (i) Anaplastic grade III gliomas: Histomolecular characterisation samples are stored at laboratory to facilitate research on candidate (ii) Role of IGFBP isoforms in glioblastoma pathogenes (iii) genes and epigenetic work for the purpose of research projects, PhD Chromosomal aberrations in atypical and anaplastic meningiomas (iv) thesis, MD thesis and diagnostic work. 10 PhD, 8 MD students and 9 Molecular characterisation of medulloblastoma (v) Proteomic profiling BE/MSc students were, or are being, trained during this period. One of medulloblastoma (vi) Molecular profiling of ependymomas. SRF, 2 JRFs and 1 PhD scholar were trained in PBMC isolation and lymphoblastoid cell line generation during this period. Ongoing research activities: (i) Histo-molecular characterization of Peritumoural Brain Zone Completed research activities: in Glioblastoma; (ii) Mitochondrial DNA copy number variation Genetics of movement disorder.
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Ongoing research activities: Cell Culture and Stem Cell Biology (Faculty In-charge: The protocols for leukocyte isolation from peripheral blood (PBMC), Prof. TR Raju) Epstein Barr virus supernatant generation and lymphoblastoid cell line establishment (LCLs) are established and samples are processed Current focus of this laboratory is to investigate the pathomechanisms appropriately. Till date 280 PBMC’s were isolated and stored during of neurodegenerative diseases such as ALS and PD using in-vitro the period 2015-16. LCLs were established for 150 samples with model systems. Additionally, research on miRNA regulation of neuropsychiatric conditions till date (Dementia, bipolar affective Müller glial cell inflammasome during HIV infection in the retina as disorder, obsessive compulsive disorder, Huntington’s disease and well as the regenerative mechanisms activated following an insult in spino-cerebellar ataxia). Using lymphoblastoid cell line as model an animal model are being studied. system, thesis works are carried out on Alzheimer’s disease, bipolar affective disorder and obsessive compulsive disorder samples. The The laboratory is well equipped with the essential infrastructure for CoE grant under the DBT is making progress. Candidate gene and successful functioning of the lab. Currently primary cultures of motor epigenetic work are carried out in alcohol dependence samples. neurons, astrocytes, microglia, olfactory bulb; cell lines of motor neurons (NSC-34), dopaminergic neurons (N27), neuroblastoma The lab has several ongoing research projects. Accelerator program for (SHSY5Y) and glioblastoma (U251MG, U87MG) as well as the discovery in brain disorders using stem cells (ADBS) project initiated human embryonic Human Embryonic Stem Cells (BJNhem20) are from January 2016. grown in this laboratory. Several funded projects are being executed in this laboratory. Research scholars (PhD. and MPhil Scholars as well Patient care services: as DM neurology residents) from other departments of the institute Genetic testing for DMD/BMD and SMA is carried out by MLPA and several external trainees are utilizing the available facilities. and PCR-RFLP method respectively. The diagnostic work was initiated as self-sustaining project from April 2015. A total of 332 Completed research activities: individuals and their families utilized the diagnostic services (101 (i) A study on the glia-NSC-34 co-cultures in response to ALS-CSF; clinically suspected SMA samples and 231 clinically suspected DMD (ii) A study on the electrophysiology properties of NSC-34 motor samples). neuronal cell line.
Molecular diagnosis was positive for 56 SMA samples and 121 Ongoing research activities: DMD samples. A total of 204 individuals and their families availed (i) Directed differentiation of human embryonic stem cells into motor the services for genetic counselling and testing for the movement neurons, their characterization & use as a cellular model for sporadic disorders (HD/FRDA/SCA) of which 78 individuals were confirmed amyotrophic lateral sclerosis; (ii) Functional impairment of motor by genetic testing. neurons in a rat model of Sporadic Amyotrophic Lateral Sclerosis (iii) miRNA mediated regulation of Müller glial cells innate immunity Bioinformatics Laboratory (Faculty in Charge: Prof. V Ravi) under inflammation.
The Bioinformatics and Proteomics Laboratory at Neurobiology Electrophysiology Laboratory (Faculty In-charge: Prof. BS Research Centre is actively involved in genomic, proteomic, Shankaranarayana Rao) phospoproteomic and glycoproteomic analysis of various human tissues, body fluids and cell lines to understand the cellular biology. The electrophysiology laboratory is engaged in evaluating the synaptic The main areas of thrust at this laboratory are study of proteomic plasticity mechanisms in various animal models of neurological and map of human brain; chronic meningitis including tuberculous psychiatric disorders. Activity-dependent synaptic modulation and meningitis, cryptococcal meningitis, and toxoplasma encephalitis; information processing in live brain slices of the hippocampus and infections including rabies encephalitis, pathogenic fungi and medial prefrontal cortex are being studied. cerebral malaria and neurological disorders such as stroke, ALS, schizophrenia, muscle dystrophy, traumatic brain injury, and The researchers are also studying plasticity mechanisms in the X-linked intellectual disability. hippocampus, cortex and amygdala in animal models of stress, anxiety, depression and epilepsy. Several strategies to restore cognitive deficits and The centre is involved in the execution of several projects abnormal synaptic plasticity in the above mentioned disease conditions in collaboration with the scientists from the departments of by rewiring and remodelling of neural circuits including pharmacological Neuropathology, Neuromicrobiology, Neurovirology, Neurooncology, and non-pharmacological approaches have been developed. In addition, Neurophysiology and Neurochemistry. As many as 18 projects have the researchers have used microelectrode array technology for in vitro been completed so far and 22 projects are in progress. recording of electrophysiological activity of neurons.
National Institute of Mental Health and Neuro Sciences 109 Annual Report 2015-2016
Completed research activities: Completed research activities: Researchers in this laboratory have studied: (i) the effect of To understand the mechanisms of ATP induced hyperalgesia the inactivation of amygdala in amelioration of stress-induced expression and functional characteristics of several purinergic receptors cognitive deficits by restoring abnormal synaptic plasticity in the in dorsal root ganglion (DRG) neurons and surrounding satellite glial hippocampus and prefrontal cortex, (ii) role of chronic exposure to cells (SGC) were studied. It was observed that some metabotropic enriched environment and antidepressants treatment on restoration purinergic receptors are exclusively expressed in satellite glial cells but of hippocampal structural and functional plasticity in endogenous contribute in pain signalling via neuron-glia interaction. animal model of depression, (iii) the cellular and molecular basis of temporal lobe epilepsy-induced cognitive deficits and Ongoing research activities: abnormal synaptic plasticity, (iv), role of enriched environment The focus of the research was to understand the neuron- and antidepressants on depression-induced cognitive deficits and glia interaction in neurological disorders. Role of glial cells in (v) and protective effect of chronic treatment with medicinal plant epileptogenesis was investigated. The morphological and functional extracts oil on stress-induced cognitive impairments and diminished changes in hippocampal astrocytes were studied in and animal model hippocampal synaptic plasticity. of temporal lobe epilepsy. Further the association of such astroglial changes with neuronal hyperactivity were investigated in different Ongoing research activities: phases of epileptogenesis. Researchers in this laboratory are currently focusing on (i) studying the cellular and molecular basis of endogenous depression induced Glutamate induced excitotoxicity is a major contributory factor in abnormal synaptic plasticity in the hippocampus interms of pathogenesis of Amyotrophic lateral sclerosis. High extracellular evaluating altered long-term potentiation (LTP) and long-term glutamate leads to excitotoxicity in neurons. Since astrocytes play a depression (LTD); (ii) evaluation of antiepileptic activity of both crucial role in glutamate homeostasis, the investigators studied the crude and active components of medicinal plants; (iii) the cellular and glutamate handling capability of astrocytes in the dorsal and ventral electrophysiological basis of restoration of stress-induced cognitive horns of spinal cord. There was drastic decline in the expression of deficits and altered synaptic plasticity by chronic treatment with glutamate transporters and transporter currents in the old animals. Celestrus paniculatus; (iv) the synergestic action of short-duration enriched environment with sub-effective doses of antidepressant Another study explored the role of cytosolic HDACs in the pre treatment on depression induced cognitive deficits; (v) role of and post synaptic functions of excitatory hippocampal neurons. enriched environment and antidepressants on chronic stress-induced The HDAC isoforms under study include Type II class of HDACs depression and cognitive deficits; (vi) modulation of amygdalar (HDAC4, 5, 6, 7, 9, and 10) and few isoforms of the Types I class. activity and its impact on stress-induced cortical plasticity; (vii) evaluating the role of enriched environment and antiepileptic drugs Neuromuscular Laboratory (Faculty In-charge: on epilepsy-induced abnormal electric activity on the hippocampus, Prof. AB Taly) cortex and amygdala; (viii) effect of modulation of glutamatergic The Neuromuscular Laboratory in keeping with its mandate has transmission and brain stimulation rewarding experience on anxiety continued to provide advanced diagnostics and promote research in and depression; and (ix) Epilepsy-induced synaptic remodelling in neuromuscular disorders. The Self Sustaining Diagnostic Facility the hippocampus. initiated last year to provide advanced diagnostic tests for immune mediated disorders and muscle disorders is successfully running. This Optical Imaging Laboratory (Faculty In-charge: Prof. Preeti facility was initiated with a seed grant from the Institute with primary Joshi) objective of providing expensive and sophisticated tests available to patients admitted at NIMHANS at affordable price as well as other This laboratory is an advanced facility for conducting real time hospitals in and around Bangalore. This has been running successfully recording of signalling events in cells and tissue. The laboratory is and new tests have been introduced expanding the scope of tests. In equipped with confocal microscope, epifluorescence systems for the last year, 4713 tests for autoimmune diseases and 225 cases (868 imaging and patch clamp setup for electrical recording from cells. tests) of muscle diseases (mitochondrial assays 808, Western blot for These techniques are being used by the researchers to unravel LGMD 60) was carried out. Availability of these tests has greatly the cellular and molecular basis of physiological and pathological benefited patient care by assisted in precise diagnosis, and taking signalling in the nervous system. The long term objective of the therapeutic decisions and timely institution of therapy. research is to identify the defective signalling modules and its origin at molecular level (ion channels/receptors etc.) in neuro-psychiatric Research in the last year has focussed on analysis of respiratory disorders. This can be translated in to targeted therapy by developing chain complexes in muscle tissue of patients with clinical diagnosis drugs against the identified molecular targets. of mitochondrial disorders and its correlation with the phenotype
110 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 and genotype. Complete mitochondrial gene sequencing, clinical Ongoing research activities: exome sequencing to identify nuclear gene mutations and nuclear- (i) Analysis of the epigenetic regulation of red/ox mechanisms mitochondrial intercommunication disorders is under study. in neurotoxic models of Parkinson’s disease involving investigation of the role of chromatin modifications; (ii) Neuroprotective effects Research in peripheral neuropathy has focused on determining the of nano-assisted C60-pyrimidine derivatives in neurotoxic models immunological mechanisms of GB Syndrome with specific reference of Parkinson’s disease; (iii) Analysis of natural products and their to Th17-mediated immune response. The role of several nuclear derivatives in experimental models of Parkinson’s diseases; (iv) genes, mitofusin-2 in particular will be evaluated in hereditary axonal Analysis of transcriptomic and epigenetic mechanisms associated neuropathies and mitochondrial neuropathies. Immunopathogenetic with 3-nitropropionic acid neurotoxicity; (v) Comparison of differences between paralytic rabies and GB syndrome is under study Manganese and MPTP toxicity: Implication for movement with emphasis on proteomics in CSF between the two diseases to disorders. determine potential biomarkers, if any to differentiate between the two disorders that closely mimic each other. Two projects to study the Patient care services: presence and role of antibodies against novel ganglioside complexes The laboratory contributes to the five mitochondrial assays and five are underway. Systematic analysis of antibody profile in patients with western-blot based diagnostic tests, carried out by the Neuromuscular myasthenia gravis has been done and is nearing completion. Laboratory.
Availability of testing facility for Neuromyelitis optica and autoimmune Cognitive Psychology & Cognitive Neurosciences encephalitis has helped diagnose several patients and provided an Laboratory (Faculty In-charge: Prof. Mahendra P Sharma opportunity to learn about these emerging entities. The clinical, and Dr. Shantala Hegde) electroencephalographic findings and response to treatment in children diagnosed to have anti-NMDAR Encephalitis is being evaluated. The focus of this laboratory is to carry out research in the area cognition and cognitive neuroscience with special interest in the area Diagnostic services: of neuromusicology and music cognition. The research work aims (i) Autoimmune tests include ANA (1742 tests), ANCA (1401 to examine the neural correlates and cognitive processes involved in tests), NMO (aquaporin 4 antibodies, 582 tests); encephalitis mosaic music perception, production and cognition from both basic science (NMDA and VGKC complex, 657 tests) and paraneoplastic neuronal approach and application of the findings to clinical set up. antibodies (326 tests) are being offered. It has also been offered as a referral service for benefit of patients in hospitals in and around Ongoing research activities include: (i) Musical Improvisation in Bangalore. Total of 4713 tests have been performed this year. Jazz and Hindustani Musicians: a Cross-Cultural EEG Study; (ii) Influence of drone induced tonic on emotive response to melody on a Testing for myositis profile has been initiated and the panel of diatonic scale; (iii) Development of a CNS based paradigm to detect paraneoplastic antineuyronal antibodies has been expanded to include deception (DST Project). 12 antigens.
(ii) The laboratory continues to provide five mitochondrial assays and The Virtual Department of four western-blots based diagnostic tests. Clinical Neurosciences The research staff members of Neuromuscular Laboratory have assisted the Department of Neuropathology in performing muscle The Virtual Department of Clinical Neurosciences has been created immunohistochemistry for muscular dystrophies 312 cases (1631 tests). to foster research temperament amongst medical graduates with brilliant academic records. The long-term objective of creation of the Neurotoxicology Laboratory (Faculty In-charge: Dr. discipline of Clinical neurosciences is to boost capacity at the national Srinivas Bharath) level in the emerging field of Translational Medicine, specifically as it applies to Neuroscience. The Institute envisages that the newly set-up The Neurotoxicology Laboratory focuses on investigating the department would succeed in bringing out clinician-neuroscientists, mechanistic and therapeutic aspects of neurotoxic models with who are equally adept in both clinical and research aspects, unlike implications for degenerative diseases. To understand the toxicological the dichotomy that seems to exist at present. This new enterprise, basis of disease, the laboratory employs biochemical, proteomic and therefore expects to bridge the wide gap that exists between the epigenetic methods. The laboratory focuses on the role of oxidative “bench and the bed-side”, thereby leading to translational research stress and mitochondrial damage in neurotoxicity. that will have more direct clinical applications.
National Institute of Mental Health and Neuro Sciences 111 Annual Report 2015-2016
The Department has three adjunct faculty members: Dr. John P. including letter writing (Write a letter to a person experiencing John (HoD and Professor of Psychiatry), Dr. Srinivas Bharath suicidal thoughts) and poster (on the theme ‘Look out for each other’) (Additional Professor of Neurochemistry), and Dr. A. Arivazhagan competitions to mark World Suicide Prevention Day 2015. A team (Additional Professor of Neurosurgery). Dr. Vani Santosh (Professor event, ‘Conduct a campaign in your campus’, based on mental health of Neuropathology) served as the Head of the Department for a promotion and suicide promotion was also held. Thirteen educational period of three years (2013-2016). The Department currently has 25 institutes from different parts of the country (Bangalore, Trivandrum, PhD scholars (5 candidates per year) who are selected and provided Coimbatore, Rajkot (Gujarat), New Delhi) took part in this event. financial support under the Indian Council of Medical Research About 130 youth with their supporting faculty actively took part (ICMR) Talent Search Scheme (TSS). Five candidates who have in conducting the campaigns, reaching out to the masses of people, completed MBBS with brilliant academic records are selected each inside and outside their respective campuses. year on the basis of a competitive national-level entrance examination and personal interview, conducted along with the annual entrance As a part of the outreach programmes, SHUT services conducted examinations for all courses at NIMHANS. workshops at Bishop Cotton Women Christian College (6 August 2015) and Kendriya Vidhyalaya (31 October 2015), Bengaluru to raise awareness about technology addiction. 65 students participated Nimhans Centre for Well Being in the program.
NIMHANS Centre for Well Being (NCWB), an urban community centre, aims at working on preventive and promotive aspects of mental Centre for Public Health health. NCWB offers clinical services and organizes various training and outreach programs. The clinical services include psychological The Centre for Public Health (CPH), established at NIMHANS interventions and psychiatric help for minor mental health issues. The in November 2012, provides inputs for strengthening public health centre runs 13 clinics and a parent support group (Aasare). response to Mental, Neurological, and Substance Use Disorders, Injuries and other Non-Communicable Diseases. The main areas During the year under review, about 75 interactive workshops and of work include human resource development, strengthening public health education programmes were conducted for various groups – health research, policies, programmes and advocacy. students, parents, teachers, elderly, general public, mental health professionals and medical professionals—on topics related to mental CPH has identified Kolar district, about 72 km from Bengaluru, health promotion and prevention. The centre has trained more than as its public health observatory and formal activities in this regard 2000 people in the community on different aspects of mental health, were launched in 2014. During the year 2015-16, the centre initiated which includes both in-house and outreach services in the last one systematic capacity strengthening activities to improve service delivery year. Various outreach programmes on mental health education were for mental, behavioral and substance use disorders, and integrate organised for Anganwadi children, adolescent girls and teachers of mental health services into NCD care. Training programmes were a few government schools, and young mothers in Primary Health conducted for all cadres of health personnel in Kolar district. During Centre. the year, 54 specialists, 97 medical officers, 50 private practitioners and 878 ASHA workers were trained in recognizing and management IEC Activities and Outreach Programmes of common mental health problems including epilepsy. The training programme was a collaborative effort of the local branches of the During 2015-16, the centre brought out five IEC leaflets on mental Indian Medical Association and the Kolar Chapter of the Karnataka health related topics: (a) Protecting children from sexual abuse (b) Government Medical Officer’s Association. IPV – Firsthand Information (c) Nurse: Nurses Recovery from Stress & Exhaustion (d) Self Injurious Behavior (e) Psychological Trauma: Continuing its commitment to strengthening public health capacity The Invisible Scars. and services, the first batch of Masters in Public Health (MPH) programme students were awarded MPH degrees at the 20th Annual Three issues of ‘The Loudspeaker – Amplifying the Voice of Mental Convocation of NIMHANS. Health’, a mental health magazine for general public were published with support from Dr. Ramachandra N Moorthy Foundation for The centre has initiated Open Academic Programme for public Mental Health & Neurological Sciences. health post graduates. In 2015-16, two such programs (Overview of Mental, Neurological and Substance Use Disorders, and Application Positive Psychology Team of the NCWB organised various activities of Census Data in Epidemiology) were planned and conducted. New
112 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 training workshops in Advanced Epidemiology and Prevention and January 2016. This report is mandatory for renewal of license to Management of MNSUDs for industrial medical officers were also conduct animal experiments at the Institute. conducted. During the year 2015-16, the CARF housed and maintained a total of Yuva Spandana Kendras (YSKs) were established in 20 districts of 85,877 animals (mice: 25,228; rats: 60,087, rabbits: 322, guinea pigs: 240). Karnataka for facilitating youth health promotion and empowerment, under the Yuva Spandana programme,. This programme has now Training Programmes been expanded to all districts in the state. At present, about 90 Yuva Parivarthakas are actively involved in providing various services to the CARF was also involved in manpower development activities youth including organizing sensitization programmes (reaching about including organizing IAEC meetings and conducting training 2.32 lakh youths in state). A set of 10 training modules has been programmes in handling laboratory animals and legislation on the use developed, as part of the programme. of animals for experiment and animal welfare. A total of 49 students and researchers from NIMHANS (26), as well as from outside To strengthen setting-based approaches in public healthcare, with institutes (19 from National Institute of Unani Medicine, Bangalore, special focus on mental health, development courses and symposium two from Kuvempu University Shimoga, and two private candidates), were organised. A Pre-conference Professional Development Course attended and successfully completed the course on Care, Breeding and on mental health, substance use disorders and injuries was conducted Management of Laboratory Animals. during the 66th Annual National Conference of IAOH at NIMHANS where 180 industrial doctors participated. Sessions held as part of the Institutional Animal Ethics Committee (IAEC) course included Injury Prevention in Workplaces, Control of Alcohol Use in Workplaces and Making Sense of Occupational Health Data. During the year the Institutional Animal Ethics Committee (IAEC) A symposium on ‘Child mental health in India: Catalyzing the met four times and a total of 42 research projects were placed before public health response’ was organised jointly with Dept. of Child the IAEC for consideration to conduct research-using animals. Out & Adolescent Psychiatry with an objective to review the ongoing of the 42 projects, 13 were new, 16 submitted for renewal, seven for activities/programmes in health and health-related sectors and catalyse extension and six referred to Institutional Biosafety committee (IBC) the public health response in promoting better implementation of for clearance to conduct experiments by IAEC. child mental health services in the Indian scenario. Following is the list of a few new projects approved by the IAEC in the year 2015-16, for which CARF has extended its facility. Central Animal Research Facility Neurophysiology The Central Animal Research Facility (CARF) was started in the 1. Implication of ventral subicular lesion on circadian behaviors in year 1979 for pursuing and conducting research and training in rodents. neurobiological sciences. At CARF, adequate care is taken to follow rules and regulations, and humane care of laboratory animals, as 2. Modulation of glutamatergic transmission in epileptogenesis proposed by the Ministry of Social Justice and Empowerment, and epilepsy-induced cognitive deficits. Government of India, the Committee for the Purpose of Control and Supervision of Experiments on Animals and the Breeding of and 3. Cellular and molecular basis of temporal lobe epilepsy Experiments on Animals (Control and Supervision) Rules 1998 and induced cognitive deficits: Role of enriched environment and 2001. levetiracetam treatment.
The CARF maintains good standards in husbandry practices, uses 4. Evaluation of electrophysiological changes in primary spinal laboratory animals for research responsibly and is deeply committed cord cultures exposed to ALS-CSF using Micro electric array. to the principle of 3 R’s: Reduction, Replacement and Refinement of use of animal for research. 5. Pathophysiology of sleep in rats prenatally treated with valproic acid. Control and Supervision of Experiments on Animals (CPCSEA) nominee inspected CARF on 12 January 2016 and submitted the Biophysics inspection report to the Ministry of Environment, Forest & Climate 1. Generation and characterization of induced pluripotent stem Change (Animal Welfare Division), Government of India on 16 cells from peripheral blood cells of schizophrenic patients.
National Institute of Mental Health and Neuro Sciences 113 Annual Report 2015-2016
Neurosurgery Biomedical Engineering 1. Comparison of two techniques of handling vessel ends during micro-vascular anastomoses. The Biomedical Engineering (BME) Section of NIMHANS provides technology management and supports equipment planning, 2. Neuroprotective role of Triphala Churna in Blast Induced acquisition and integration. It is also responsible for testing, repairing, Neurotrauma. and maintenance of medical (diagnostic and therapeutic) equipment in the Institute. The section’s efforts are directed towards biomedical 3. The role of stem cells in sciatic nerve regeneration in rat with and radiographic devices and systems used in a variety of patient care cold preserved allografts: Functional and histological outcome. and care-support services. It focuses on improving patient care through maximizing operational availability of technology, minimizing risk to patients, visitors, and care providers. Neurochemistry 1. Evaluation of neuroprotective properties of Emblica officinalis NIMHANS Data Centre (Indian gooseberry) and Zingiber officinale (dry ginger) in non- transgenic Alzheimer disease (AD) rat model: A biochemical NIMHANS has setup a data centre to accommodate different and Behavioural study. facilities required to run various hospital applications smoothly. This data centre is equipped with more than 19 servers, storage 2. Immunotherapeutic potential of N-terminal fragments of Tau infrastructure and high speed network connectivity. Now more than (NTF-Tau) in tauopathy model rats. five applications, related to different areas like project, salary, etc. are running successfully from this data centre. New-generation-higher- end network devices like firewall, layer-3 switches are also included. Neuroanaesthesia 1. Effect of pentoxyphylline on microvascular flow pattern in One new mini data centre using very advanced integrated infrastructure experimental cerebral vasospasm model. is almost ready. This will act as a near Disaster Recovery (DR) centre. Both these data centres are connected by 10gbs links incorporating high redundancy feature. IBC cleared projects and approved by IAEC The power and cooling infrastructure has also been upgraded by installation Neuropathology of additional high capacity generators, precision AC units and UPS. 1. Development of zebrafish as model system to study the etiology and patho-physiology of actin mutations that causes nemaline Disaster Recovery Centre has been set up to provide business rod myopathies in human. continuity and protect the critical patient data in the event of a natural disaster or other emergency that causes downtime of the Data Neurophysiology center. It is running on 10 Gbps bandwidth connectivity to critical 1. Evaluation of efficacy of nutritional preparations and specific departments like Emergency, OPD, Neuro Center and laboratories nutritive ingredients in the management of cognition in suitable which are patient data intensive. animal models. With storage-to-storage replication and virtualization technologies 2. The role of glia in aging and in determining the differential between sites, the DR is having very short recovery time by susceptibility of two mice strains to 1-methyl-4-phenyl-1, considering the Recovery Point Objective and Recovery Time 2,3,6-tetrahydropyridine(MPTP). Objective as 15 minutes to make high availability of data. The DR is setup with Modular Safe, a state-of-the-art technology with IP56 and 3. Modulation of neuronal cytokines (IL-2 and TNF-a), and F90 standard which ensure the fire, water and dust protection in a cost cytokine receptor expression due to Benzo[a] Pyrene exposure effective manner. Virtualization environment for hosting application in rat brain. with site recovery feature has been enabled.
NIMHANS Network Neurochemistry 1. Analysis of transcriptomic and epigenetic changes in the Initial phase of network implementation has facilitated connection 3-nitropropionic acid (3-NPA) neurotoxic model: Focus on to various departments of NIMHANS with 10G or 1G single mode mitochondrial function.
114 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 fibre in redundant manner to boost the performance in accessing the Equipment maintenance entire applications across the campus. In addition to preventive maintenance, calibration and installation A local ring connecting Institute’s existing Data Centre with different of multiple equipment(s), the section offers services for clinical building has been established for redundancy purposes. Installation equipment owned and used within the hospital, in compliance with of another level of network link redundancy is in process to facilitate regulatory agencies. Pre-purchase evaluations of new technology access to critical applications during the time of disaster through and equipment and assistance to clinical departments in service disaster recovery setup. contract analysis, negotiations and management are also provided. Coordinating clinical equipment installations and conducting New generation L3 switches have been installed in each building device incident investigations form the other services extended by along with 1gbps new access switches to enhance the performance. the section. Wireless network has also been upgraded by installing new APs along with facilities for differentiating the guest and normal users’ traffic Heavy duty steam sterilizers, ETO gas sterilizer, glove washing and giving individual password to users. machines, air blowers & ultrasonic cleaning machines at the Central Sterile Supply Department (CSSD) are regularly maintained by the Wireless network has now been extended to the entire campus by BME section to ensure smooth functioning. installing new APs with building-wise VLANs for enhanced security along with facilities for differentiating the guest and normal users’ A range of cooking equipments (in the Dietary Section) operated traffic by giving individual password to users binding their devices. through both steam and electricity including bulk ovens, wet grinders, cooking gas line, food distribution trolleys, exhaust hood system, Audio-Video Integration & Presentation Systems etc. are being maintained and preventive maintenance carried out regularly by the BME section. NIMHANS is equipped with the latest audio and video integration systems with wireless presentation facility in major conference rooms The mechansied laundry section consists of heavy duty washing and virtual classrooms. Hardware and associated software support machines, hydro extractors, steam boilers and calendering, ironing, for these facilities are provided by the BME section. Digital Signage dry-cleaning machines. Approximately 1000 kg of wet linen is being System is made available in the OPD and Emergency Services units washed every day by passing high pressure steam to kill bacteria. The as a centralized content delivery system. up-keeping, repair and maintenance of the above equipment are being carried out by the BME section. Cyber Security In order to cater for the requirements of medical gases to the patient NIMHANS has taken necessary security protection for network, care in the neuro and psychiatry wards, centralized medical gas servers, applications and client systems by using network firewalls, system equipment have been installed at two different blocks. The Intrusion Detection Systems/Intrusion Prevention Systems, system consists of heavy duty air compressors, vacuum pumps, liquid Application Firewalls, etc. Putting servers in DMZ zone, oxygen plant and nitrous oxide manifold. The plant is being operated implementing client-server antivirus infrastructure, restructuring round the clock and BME is responsible for the maintenance works. of the network, log analysis, security incident monitoring, etc. have The pipeline is provided in all the wards up to the patient bed and ensured better protection. The Web Security Gateway solutions have continuous monitoring is carried out for leaks, ensuring smooth been implemented for secured Internet access. SSL encryptions are functioning of the system. made for critical web applications. Video Conferencing Services Central Telephone Exchange Multipoint Video Conferencing (VC) hardware is being used for NIMHANS Exchange is running on Ericsson Digital EPABX conference purposes at NIMHANS. Any user connected through with 1000-line capacity. The entire Institute’s and resident quarters’ National Knowledge Network (NKN) or Internet can conduct high telephone distribution and maintenance are handled by the BME definition quality VC in point-to-point or multipoint conference by section. In addition to the telephone lines, the Closed User Group using their VC devices. Virtual Class Room has been setup through (CUG) mobile services provided through BSNL scheme has been NKN and weekly training programmes has also been started using integrated into the EPABX for mobile communication among custom third party software, where users can take part in a programme by users of the Institute. using their laptops, smart phones, tabs, etc.
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Projects and Training Usage statistics of library resources
The BME section offers various training programmes to Books and journals circulated 5592 undergraduate and graduate-level students and encourages them No. of pages of photocopying 25200 to undertake projects in the area of Biomedical Engineering. The No. of internal users of the library 29348 students can take up interdisciplinary projects for a (minimum) No. of external users of the library 4506 duration of three to 10 months. To register for short term and long Literature searches 170 term projects, enquiries can be sent to [email protected]. or No. of cyber hall users 2886 [email protected] Full text article downloads 232561
Subscription of resources Engineering The library subscribed to a large number of journals, books and The Engineering Department caters for the maintenance of databases. The journals and books included both print and electronic hospital infrastructure, administrative building, staff quarters, roads, resources. machinery and equipment like air-conditioners, lifts, generators, etc. The activities are covered under plan and non-plan head of account. E-journals Some of the major civil and electrical works completed in the year 2015-16 include: (a) Construction of additional first and Sl. No. of Full Articles List E-Journal database second floors in the Child and Adolescent Psychiatry block (b) No. Journals Downloaded construction of concrete solid block masonry compound wall with EBSCO: Psychology & Behavioural 1 539 15681 barbed wire fencing at NIMHANS Northern Campus, KR Puram, Collection Bengaluru (c) construction of bus/car shed/garages BRC campus, 2 Elsevier Health/ Clinics 21 23728 Administrative Block (d) upgradation and renovation of the ground 3 Elsevier/ Science Direct 148 76720 and first floors of staff hostel, NIMHANS campus, Administrative Block (e) conversion of existing vacant room adjacent to Neuro 4 JAMA 6 1097 Infection Ward into deluxe rooms at first floor of Ashwini Block 5 Karger 23 1992 (f ) modernization of water supply system at LMRH, OPD, etc., 6 Maney Pub. 3 3609 NIMHANS Byrasandra campus (g) construction of the first floor of Ayurveda block/building (h) providing 100 KVA HT power 7 Nature 13 10690 and 11 KVA substation with transformer centre at Sakalwara 8 Ovid 26 8417 Community Mental Health Centre campus (i) construction of MR 9 Oxford Uni. Press 10 890 PET building (j) construction of canteen for the staff and students at Administrative block. 10 PAIN® 1 209 Proquest Collections (APA, Med. 11 3035 12504 Construction of NIMHANS Sub-specialty Block in Neuro Centre, Complete, Psycharticles, Nursing) Cyclotron and intraoperative buildings among other projects are in 12 Psychiatry Online 4 3090 brisk progress. 13 RCNi 3 1824
14 RSNA 2 976 Library and Information Centre 15 Sage 74 3036 16 Science 1 1498 The Library & Information Centre strived to make more and more 17 Society/ Single Jls - SGM 30 34150 user services to be computer based. As a result more number of data bases and e-books were subscribed to in the year as also applications 18 Springer 105 3130 like anti-plagiarism software. The entire library complex is Wi-Fi 19 Taylor and Francis 186 3102 enabled now and there are more than 200 points for charging laptops. 20 Thieme Neurosurgery 3 103 A large number of external users from different institutions in the country continued to use the library resources at the institute. 21 Wiley Blackwell 42 10165 Total 4275 216611
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E-books Circumstances: A Handbook (in Kannada); Proceedings of the Symposium on ‘Integrating Scientific and Contemplative Approaches to Explore the Mind; Epilepsy: A Guide for Teachers; Nuts and Bolts No. of Book Sl. No. of E Publishers / Aggregators Chapters of Starting and Running Psychiatric Rehabilitation Services; Quality No. - Books Downloaded of Life in Chronic Mental Illness: Exploring New Frontiers. 1 Access Neurology Collections (2015) 103 995 Institute Reports: The Annual Report 2014-15 (both in English and Springer - 2 378 9444 Hindi) was successfully brought out by the department, under the Behavioural Science Collection aegis of the Co-ordinating Committee formed by the Director. The Psychiatry Online - 3 22 1489 Institute Activity Reports—which present comprehensive information American Psychiatric Association of the Institute’s activities, developments and achievements—were also 4 Theime - eNeurosurgery 144 4022 generated for Governing Body and Academic Committee Meetings Total 544 15950 held during the period under review.
Information Materials: Copyediting/proofreading of leaflets, flyers, Print journals subscribed to include Elsevier Collections (27) prospectus and other vital information materials were carried out. and Karger Neuro Mental Health Collections, and other online Printing and publishing of Convocation materials were also handled bibliographic database include Access Neurology Collections (103), by the department. Thieme E-Neurosurgery database (144), API/American Psychiatry Online (22), Springer Behavioural Science Collection (378), EBSCO Language Classes: The Department organised Kannada classes in Host: Psychology & Behavioural Sciences Collection, and Proquest association with the Kannada and Culture Department, Government collection of online databases. of Karnataka, for the benefit of non-Kannada speaking faculty and staff. English classes for BSc Nursing (I year) students were also A total of 111 books were added to the collection, during the year. coordinated by the Department. New software services/facilities—Turnitin for plagiarism check, EZProxy for off-campus access and LibSoft for library maintenance Other Activities: Certificates for consent forms (to be presented have been made available. to the Ethics Committee) of various research activities were issued after comparing/checking the veracity and correctness of the Further automation of library operations and starting of an translated forms with the original version(s). Publications storage and institute repository will continue to be pursued in the coming year. inventory management, translation of notices and vital administrative Development of consortia of medical libraries related to mental communications into regional language, coordinating translation health and neurosciences, at least in Karnataka, will be pursued. works with the Institute of Translation Studies, checking name Optimization of the usage of library space will be taken up along with boards/signboards, rubber stamps, etc. were the other activities carried the development of a boardroom with a facility for video conference out on a regular basis. on the library premises. Hindi Cell
Publication Department Hindi Cell, functioning under the Publication Department, undertook various activities under the guidance of the Department The Department of Publication continued to provide an efficient of Official Language, Union Ministry of Health and Family Welfare, system for disseminating knowledge about mental health and Government of India with a view to ensure compliance with the neurosciences through various specialised services and other important Official Language Implementation policies and Constitutional activities during the review period. It facilitated publication of books, provisions, and to promote progressive use of Hindi for the official teaching manuals, technical reports and other important documents purposes. for academic and administrative purposes. Translation Activities: Consent forms for research/academic Manuals/Handbooks/Scientific publications: In 2015-16, activities, tender notifications, and other important correspondences the department undertook copyediting and proofreading—and were translated into Hindi, on a regular basis. coordinating the printing—of the following publications: Activities of Daily Living for Persons with Mental Illness—A Book for Caregivers; Correspondence in Hindi: Letters to offices of the Central Handbook of ECT; Psychosocial Care for Children in Difficult Government, located in regions ‘A’, ‘B’ and ‘C’, as classified by the
National Institute of Mental Health and Neuro Sciences 117 Annual Report 2015-2016
Ministry, were issued in Hindi to the extent possible. Official government. Prizes to the winners of various competitions held as documents pertaining to the Ministry were being signed by the part of the Hindi Week Celebrations and certificates (of attendance) Director and Registrar in Hindi. to the participants of the Hindi Workshop were distributed on the occasion. All name boards and sign boards of the Institute have been displayed in trilingual format (English, Hindi and Kannada). Thought for the Day was written in Hindi and English, every day, on the display boards NIMHANS Gymkhana at Ashwini Block and Neuro Centre for the benefit of employees/ hospital staff and to facilitate learning of Hindi. The NIMHANS Gymkhana is a recreational and sports facility provided exclusively to the staff, students and their families. Situated Hindi Training: Hindi course/classes (Probodh, Praveen and Pragya), on Byrasandra campus of NIMHANS, Gymkhana has been built in under the Hindi Teaching Scheme, were conducted regularly to an area of 2,535 sqm with a plinth area of 10,320 sqm. The Gymkhana impart training of Hindi to the employees of the Institute who do not has the state-of-the-art facilities and equipment for sports, physical possess the working knowledge of Hindi. Hindi Typing and Hindi activities and recreation. It has multiple facilities for various indoor Stenography training was also provided under the scheme. games like badminton, table tennis, carom, chess and basketball. It also has crèche, library, men and women gymnasium wings, locker Hindi Week Celebrations: rooms, utility/yoga room, amphitheater, and a community hall.
Hindi Week was celebrated at NIMHANS in the month of December Indoor/outdoor sports and cultural competitions were held for the 2015. A three-day official language workshop (by Shri. M.P. staff and students of NIMHANS, between 4 January 2016 and Damodharan, Hindi Teaching Scheme, Kendriya Sadan, Bengaluru) 5 February 2016. The events evoked overwhelming response and and various other competitions such as essay writing, debate, noting saw participation from large number of staff and students. Prizes and drafting, singing, etc. were organised as part of the Hindi Week to winners of the competition were presented at the Institute Day celebrations. Celebrations function.
Valedictory Function of the Hindi Week Celebrations 2015 was Apart from holding sports and cultural activities, Gymkhana, in an held on 31 December 2015. Shri. P. Vijay Kumar, Deputy Director effort to encourage academic excellence, presents cash awards to (Implementation), Regional Implementation Office (Ministry of meritorious students by presenting and distributes free note books to Home Affairs, Govt. of India), Kendriya Sadan, Bengaluru was the the children of the staff. Chief Guest. During the year under review, CCTV surveillance system with 10 The Chief Guest, in his address, said Hindi is an important cameras, covering the whole of the Gymkhana premises, was installed. medium of communication for exchange of views between the Art classes for children above five years of age and training in Zumba government and the public and wide propagation of the official and Mixed Martial Arts (MMA) for both adults and children of the language is responsibility of each and every employee of the central staff and students of the Institute have been initiated.
118 National Institute of Mental Health and Neuro Sciences Research Activities Research Activities
2+ Biophysics Ca signaling profile of lymphoblastoid cell lines (LCL) isolated from dementia patients and controls were studied. The lymphoblasts isolated from dementia patients showed higher basal Ca2+ level as compared to 1. Purinergic signaling in astrocytes: Implications in normal group. Within these groups the samples possessing ApoE 3/4 pathophysiology of epilepsy. (National Initiative on Glial genotype exhibited higher basal Ca2+. The Ca2+ sequestration capacity Cells in Health and Disease, DBT). Investigator: Dr. Preeti of endoplasmic reticulum and mitochondria also differed between G Joshi (Funding by DBT, New Delhi) ApoE 3/3 and ApoE 3/4 groups. Thus, the Ca2+ homeostasis appears to have altered in ApoE 3/4 group. Astrocytes have emerged as important partners of neurons in physiological as well as pathological signaling events. Majority of the past research on epilepsy has been neuron centric. The investigators have assessed the role of astrocytes in epileptogenesis and/or in sustenance of seizure activity. The study was performed in pilocarpine rat model of temporal lobe epilepsy. Purinergic receptors are the major players in astrocyte- astrocyte communication and in neuron- astrocyte signaling. The investigators examined whether there is any change in the expression and functional activity of astrocytic purinergic receptors in epileptic animals. The study was focused on initial injury phase Stimulus induced Ca2+ release from ER and mitochondria in lymphoblastoid of epileptogenesis i.e. status epilepticus (SE). Within two hours of cell lines isolated from control and dementia patients carrying different ApoE genotypes. seizure, induction significant astrogliosis occurred in specific regions of hippocampus of SE rats. The expression of metabotropic purinergic 3. Purinergic signaling in dorsal root ganglia. Investigator: Dr. receptors P2Y1 and P2Y2 was enhanced and the Ca2+ signals mediated Preethi G Joshi by these receptors were also significantly enhanced in SE rats. The neuronal activity was measured by whole cell patch clamp recording. Dorsal root ganglia play a central role in transmission of pain Activation of astrocytic P2Y2 receptor with its agonist UTP drastically signals from periphery to the brain. They are the first relay point in enhanced of neuronal activity in control rats. In SE rats the frequency the somatosensory pathway. The neuronal soma in the dorsal root of action potentials was three-four folds higher as compared to control ganglia are enwrapped by satellite glial cells (SGCs). Recent studies but there was no further increase by addition of UTP. Activation of suggest dynamic interaction between neurons and SGC may regulate astrocytic P2Y1 receptors significantly reduced the neuronal activity and pain signaling. ATP is known to be an important neurotransmitter the inhibitory effect was more pronounced in SE rats. Thus, the data contributing in pain signaling however very little is known about the suggest that the purinergic receptors in astrocytes can play a protective receptor subtypes involved in neuron-SGC interaction in DRG. The role in controlling the hyperactivity of neurons in epilepsy. investigators have investigated the expression and characterization of purinergic receptors in DRG neurons and glial cells. It was 2. Calcium signaling, mitochondrial and ER function in observed that DRG neurons possess ionotropic P2X3 receptor where lymphoblastoid cells with different ApoE genotypes. as SGC possess several metabotropic P2Y receptors. Activation of Investigator: Dr. Preeti G Joshi (Funding by DBT, New Delhi) metabotropic receptors induces Ca2+ signals specifically in SGC which in turn can modify the neuronal signal. The data suggest that Apolipoprotein E gene is considered a genetic risk factor for Alzheimer’s ATP/UTP induced hyperalgesia is most likely mediated by glial cells. disease (AD) but the biological factors linking the risk factor gene with disease are not known. Ca2+ is a ubiquitous second messenger 4. Identification of potential inhibitor against BRD2-BD2 molecule that plays a pivotal role in physiological as well as pathological using structure-based approach. Investigator: Dr. B processes. Alterations in cellular signaling can be a crucial factor Padmanabhan (Funding by DBT) contributing to pathophysiology of AD. The investigators are studying the Ca2+ signaling events in a peripheral model of a lymphoblastoid cell Bromodomains are modules conserved in several nuclear proteins lines derived from patients which differ in the ApoE genotype. The that recognize acetylated lysine residues in histone cores and regulate
120 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 epigenetically controlled processes like gene transcription and histone simulations in GROMACS for 10ns resulted in a potential list of hits. modification. Dysfunction of BRD proteins—one of the family of The recent crystal structure determination of a Brd2-BD2 complex six BET (Bromodomain and extra-terminal) domain family member with one of these hits has confirmed the findings. The investigators proteins—has been linked with development of several forms have performed structure-based pharmacophore modeling technique disease including cancer and neurodegenerative disorders. Inhibitors to develop an insilico model to incorporate the cues obtained from selectively targeting BRDs can pave path for new drug discovery the crystal structure. Cues from established inhibitors (ligand based against several forms of cancer. pharmacophore mapping) were also taken into account. Both pharmacophore modeling approaches were performed using Phase The investigators have successfully applied in-silico docking and module (Schrödinger software). It resulted in ‘targeted pharmacophore co-crystallization experiment to identify a novel phenanthridinone queries’ that sufficiently capture the necessary 3D chemical features based scaffold as potential inhibitor of BRD2-BD2. For this, the for a ligand to show Brd2-BD2 inhibition. Using this pharmacophore investigators have successfully cloned, expressed, purified and query, screening of commercially available compounds from databases crystallized BRD2-BD2. They also obtained co-crystals of BRD2- was performed. Additionally, shape similarity filter was used to take BD2 with these potential inhibitors. The X-ray diffraction data were advantage of the shape complementarity of the ligand in the binding collected on the synchrotron beamline BM14, ESRF, Grenoble, site to determine best in-class compounds. Eventually, new ‘scaffolds’ France. The structures are at the highest known resolution so far (0.91 possessing Brd2-BD2 inhibitory activity will be used to develop and 0.94 Å, respectively for complex and apo- form). These discoveries chemical libraries of compounds, to be used in future. To validate the will help designing new phenanthridinone based library as potential findings, invitro binding characterization (Kd) of these compounds BRD2-BD2 inhibitors. New structural features observed in this study using SPR analysis will be performed. will also help in better docking studies to identify novel inhibitors against BRD2-BD2.
BRD-BD2 crystals and X-ray diffraction data. A typical experimental set-up to get diffraction data from protein crystals. (A) Pharmacophore query developed based on the crystal structure. (B) Pharmacophore query designed using Structrue based Pharmacophore mapping (Schrödinger).
6. Structure-function analysis of HDAC domain of human SIRT1 and discovery of pharmaceutically acceptable SIRT1 inhibitors by rational drug design approach. Investigator: Dr. B Padmanabhan (Funding by DST)
The sirtuins are the conserved family of NAD-dependent class III HDACs, and they are an integrative link between metabolic control Crystal structure of BRD2-BD2 bromodomain complex with an inhibitor, and transcriptional regulation. Sirtuins support the longevity by L10. The2Fo-Fc electron density map of L10 contoured at 1.0σ in the binding pocket of BD2. increasing lifespan of the organism. They act as the metabolic sensors; hence regulate the pathways involved in age-related neurodegenerative 5. Drug discovery of potent inhibitors for epigenetic marker, diseases. There are seven sirtuin proteins in the family (SIRT1-7), BRD2 bromodomains by rational structure based approach. which are localized in cytoplasm, nucleus and mitochondria according Investigator: Dr. B Padmanabhan (Funding by DBT) to their functions, all possessing a highly conserved NAD-binding site and catalytic domain. The dysfunction of sirtuins may lead to diseases The investigators are developing selective inhibitors for Brd2-BD2, such as cancer and various NDs and hence, identifying potential a BET family member protein. In this effort, insilico screening of small molecule modulators to regulate sirtuins is imminent for the NCI database using AutoDockVina followed by molecular dynamics treatment of these diseases.
National Institute of Mental Health and Neuro Sciences 121 Annual Report 2015-2016
To discover new inhibitor compounds, the investigators performed phenotypes: obesity, retinal degeneration, and hearing loss. To study virtual screening for hSIRT1 against DrugBank library containing the structure of TULP3 deleted gene construction was done and 1,716 compounds and subsequently performed binding-energy cloned using pET vector and expression of protein was checked in analysis for the selected compounds. Two chemical classes, namely BL21 strain. The recombinant protein was purified using Ni-NTA dipheynyl and oxycoumarin derivatives, have emerged from affinity purification. The final purified TULP3 protein with His this study. The inhibitory activity of the predicted compounds tag was obtained from the ion-exchange chromatography. Next, is confirmed by anin-vitro deacetylase assay against four the purified protein (10mg/ml) was taken for protein crystallization commercially available drugs containing the predicted compounds. screening and is in progress. The investigators propose that the discovered hits may be potential molecules to develop new chemical libraries for inhibiting the 8. Drug discovery of novel inhibitors for human Superoxide enzyme activity of hSIRT1. Dismutase 1 (hSOD1). Investigators: Dr. B Padmanabhan, Dr. Richard Strange, Liverpool University, UK
SOD1 is an enzyme involved in detoxification, such as removal of charged oxygen molecules called superoxide radicals. The mutation in the gene causes amyotrophic lateral sclerosis (ALS). The SOD1 toxic gain-of-function is mainly due to the mutation in SOD1 gene; hence, protein gets aggregated. Since both aggregation propensity and protein stability strongly influences patient survival time after onset of symptoms, working on protein stability could be an important step Binding of predicted compounds in the catalytic binding site. to improve patient survival rate. Stabilization of the SOD1 dimer can increase the protein’s thermostability and thus, preventing monomerization and inhibit aggregation. Hence, identifying and developing potential library compounds to stabilize the functional SOD1 dimerization are needed for the treatment of ALS.
The hSOD1 cDNA was cloned in to a pET vector, expressed in the E.coli bacterial system, and the His-tag hSOD1 protein was purified by using multiple chromatography techniques. The highly purified hSOD1 protein was concentrated to 9mg/ In-vitro deacetylase activity for the compounds. (a) Deacetylase activity of hSIRT1 with and without compounds. (b) Illustrating the percentage of ml concentration and used for protein crystallizations. hSOD1 inhibition of tested compounds. was checked for its intact mass analysis and its purity by Mass spectrometry analysis. The X-ray diffraction data for the apo- 7. Cloning, expression and protein purification of TULP3 form of hSOD1 and hSOD1-ligand complexes were collected (Tubby-Like Protein 3) as a SIRT1 Interactor. Investigator: on the beamline BM14 at European Synchrotron Radiation Dr. B Padmanabhan Facility (ESRF), Grenoble, France. The structures of protein- ligand complexes and apo hSOD1 were determined and refined The TULP3 gene encodes a member of the tubby gene family of to 1.9A resolution. In addition, the SPR binding analysis was also bipartite transcription factors. Members of this family have been performed using BiacoreT100 instrument. identified in plants, vertebrates, and invertebrates and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function.
Tub-like proteins are present in all multicellular organisms. The A representative diffraction pattern of the hSOD1 complex with the genetic mutation of TULPs can result in one or more of three disease compound #44.
122 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
10. Tryptophan oxidation in myogenic proteins in neuromuscular diseases. Investigators: Dr. B Padmanabhan, Dr. Srinivas Bharath
A mass spectroscopic study carried out in mouse models and human clinical samples revealed the oxidation of tryptophan residues in cases of neuromuscular diseases (NMD). Glycerol-3-phosphate dehydrogenase (GPD1) is a peripheral membrane protein that is Crystal structure of the hSOD1 complex with ligand #44. involved the glycerol 3-phosphate shuttle, essential for the provision ATPs in oxidative phosphorylation taking place in the mitochondria. 9. Structure based and ligand based pharmacophoric drug The NAD molecule is important in the conversion of dihydroxyacetone designing approach for the Keap1 protein. Investigator: Dr. to glycerol-3-phosphate in the cytoplasm. B Padmanabhan (Funding by ICMR) Tryptophan oxidation delivers many kinds of products of which the Keap1 is a protein regulator in the cellular cytoplasm that controls MS analysis revealed the presence of kynurenine (+4), oxindolylalanine the concentration of the oxidative stress sensor protein, Nrf2. Latest (+16) and N-formylkyunurenine (+32). Such modifications may research addresses the importance of functional deactivation of introduce structural and functional changes to the oxidized protein. Keap1 in neuropathology involving oxidative stresses that demands The investigators have studied the effect of GPD1 oxidations on expression of cellular antioxidant defense mechanism. tryptophan using MD simulations. The simulation studies revealed the neighborhood effects on the oxidized amino acid along with Based on the interaction pattern of a previously published complex its extended effects on the substrate recognition and sequestration of Keap1 with an inhibitor, structure based pharmacophore was strength. All the mutant proteins are exhibit better per residue developed using the DrugBank database. Another methodology fluctuations and hence confirm the stability of the substrate in its involving consideration of the structural and spatial arrangements of binding pocket induced on the account of oxidation. Also, the overall chemical entities based on previously published predicted inhibitors of structural deviation shows that the structural stability is onset much Keap1 was used for the development of ligand based pharmacophore. before the control protein structure. Other structural differences Both the pharmacophoric fingerprints were utilized for screening include the loss of secondary structure by some residues over the the database for similar entity containing compounds. The screened simulation. These results, point out to a significant study in protein compounds were docked using AutoDockVina and analyzed for structure in cases of neuromuscular pathologies. Nrf2 mimicking interactions. A total of 9 and 10 compounds were shortlisted for structure based and ligand based pharmacophore based screening, respectively (Figure 1). MD simulations were performed using Desmond of the Schrodinger software to study the detailed stability and interaction analysis of the predicted complexes. Most of the complexes showed better or at par stability in comparison to both, the apo enzyme and known inhibitor complex. The β-propeller protein maintained its structure throughout the 10 ns simulation with negligent minor structural fluctuations. The predicted compounds are to be procured for in-vitrobinding studies.
Various regions on the GPD1 protein where stability is noticed due to tryptophan oxidation.
11. Recombinant phage lysin as anti-infective therapy against multi- drug resistant Pathogens. Investigators: Dr. B Padmanabhan, Dr. KR Chandrkanth, Gulbarga University, Gulbarga
The interaction of screened representative hits with the Kelch domain of Staphylococcus aureus, a gram-positive spherical bacterium that occurs Keap1.
National Institute of Mental Health and Neuro Sciences 123 Annual Report 2015-2016
in microscopic clusters resembling grapes. Infections caused by S. 12. Crystal structure of the thiolase-like protein, ST0096 from S. aureus include superficial infections like boils, styes and furunculosis; tokodaii DSM 16993. Investigators: Dr. B Padmanabhan, Dr. serious infections like pneumonia, mastitis; and deep seated Yoshitako Bessho, RIKEN, Japan infections like osteomyelitis, endocarditis and bacteremia. The wide spread appearance of drug resistant strains of S. aureus especially Thiolases are CoA dependent enzymes that are involved in to methicillin and vancomycin is a major issue in combating biosynthetic and degradative pathway of lipid metabolism. The these pathogens. Resistance to antimicrobial agents is not a new primary structure of ST0096 from Sulfolobustokodaii suggests that phenomenon in bacteria, S. aureus isolates showing resistant to ST0096 is closely related to the thiolase superfamily. The crystal multiple antibiotics. structure of the ST0096 protein was solved by the MAD procedure
and refined to finalfac R and Rfree values of 16.2 % and 19.4 %, There has been a renewed interest in alternative antimicrobial respectively, at 1.7 Åresolution. The asymmetric unit contains two treatments, including bacteriophages, antimicrobial peptides, intact dimer molecules. The overall tertiary structure and dimer proteins and Nanoparticles. Bacteriophages specifically infect arrangement of ST0096 suggest that ST0096 falls under the bacterial cells and disrupt bacterial metabolism and lyse the SCP2-thiolase subfamily. The putative substrate binding site and bacterium. Bacteriophage has bio-agents for the treatment of the probable interacting residues in ST0096 are almost conserved bacterial infectious diseases. The clinical use of phage lysin in compared to Z. ramigera and L. Mexicana thiolases. However, controlling virulent bacterial infection would be a better strategy to the critical catalytic cysteine residues are replaced with Ser76 and treat diseases. In this aspect, two lysin genes (endolysin and putative Met272 in ST0096. The putative function of ST0096 is discussed amidase) were isolated, expressed and the proteins purified. The based on structural homology. proteins were checked for its activity on bacterial lysis. The activity of endolysin and putative amidase was checked using turbidity reduction assay and Antimicrobial susceptibility assay. Protein crystallization is in progress for structural studies.
SDS-Page analysis of purified putative amidase and endolysin
Ribbon diagram of the tertiary structure of ST0096. It possesses two dimers (A & B and C & D)
13. Development of an in vitro model to assess the role of endogenous astrocytes and adult stem cell-derived supportive cells on the survival of midbrain dopaminergic neurons. Investigator: Dr. Indrani Datta (Finding by DBT)
Parkinson’s disease is characterized by selective loss of dopaminergic (DA) neurons in the substantia-nigra (SN) of the midbrain-region and not in the ventral-tegmental area and other catecholaminergic cell-group areas. Post-mortem analysis suggests that the main difference between these two regions of the brain having DA Turbidity reduction assay using recombinant endolysin protein neurons is the density of astrocytes. Although astrocytes throughout
124 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 the central nervous system (CNS) share many common traits, iPSCs have been developed from human fibroblast cells but recent reports suggest heterogeneity in terms of expression of membrane studies have reported iPSCs from other somatic cell types including transporters, channels, neuropeptides and gap junctions. The lymphocytes, mesenchymal stem cells, and mobilized CD34+ cells. significance of region specificity and optimum density of astrocytes Due to their commercial availability and ease of gene delivery, in constituting the endogenous microenvironment of DA neurons fibroblasts are the preferred cellular choice for reprogramming, is yet not elucidated. In the present study, the investigators first aim but the need for invasive biopsies and the difficulty of establishing to understand the role of astrocytes in the survival of DA neurons stable cell lines from primary culture limit their utility. Moreover, using an in vitro primary midbrain DA neuron culture model and skin cells harbor more mutations than cells from inside the body, further elucidate the role of undifferentiated and differentiated due to environmental insults such as UV radiation (Abyzov et al., MSCs in mimicking the supportive action of astrocytes on the 2012). Considering these limitations, cells obtained from peripheral survival of DA neurons. The investigators have isolated, purified blood are currently accepted as the best choice. Peripheral blood and differentiated astrocytes from three different regions of neonatal mononuclear cells (PB-MNCs) can be used to generate iPSCs by brain and characterized for glial markers through flow cytometry. reprogramming them with Yamanaka’s pluripotent factors Oct3/4, Moreover, a sequential culture technique is established by changing Sox2, Klf4, and cMyc. In the present proposal, the investigators dimensionality to generate neuron-glial ratio akin to in vivo adult aim to use integration-free reprogramming methods containing midbrain. At present, work is focused on unravelling the mechanism reprogramming factors Oct3/4, Sox2, Klf4, and cMyc to generate of neuroprotection of astrocytes on dopaminergic neurons under iPSCs from lymphoblastoid cells. At present PB-MNCs from stress. The survival of TH neurons, vesicular resting pool of healthy individuals are isolated and put for reprogramming. dopamine and functional release of dopamine will be investigated using a combinatorial approach involving biophysical, biochemical 15. Development and assessment of human embryonic stem and molecular biology techniques. cell derived neural progenitors as a model for hypoxic- ischemic like injury - Implications for Hypoxic Ischemic Encephalopathy (HIE). Investigators: Dr. Indrani Datta, Dr. Ramesh Bhonde (Funding by CSIR)
Hypoxic-ischemic encephalopathy (HIE) is a condition where severe brain injury occurs in neonates due to birth asphyxia (American Academy of Pediatrics). This condition can arise due to variety of perinatal causes that interrupts uterine and fetal blood flow and/ or hypoxia. There are practically no therapies other than supportive Representative immunofluorescence images of midbrain outgrowth obtained measures for perinatal HIE. The investigators propose to use neural by sequential culture technique and 2D culture. A) Represents TH (FITC, progenitors (NPs) derived from human embryonic stem cells (hESCs) green) expression co-labeled with b tubulin III (TRITC, red). Arrows indicate the TH expression. to generate an in vitro model for HIE. hESCs are unique since in being essentially derived from the inner cell mass of preimplantation 14. Generation and characterization of induced pluripotent stem embryos, are thus capable of self-renewal and differentiation to all cells from peripheral blood cells of Schizophrenia patients – three derm layer lineages. Consequently, hESCs are considered a a cell-resource to derive neural progenitors. Investigators: good reserve model for developmental events and the generation Investigators: Dr. Indrani Datta, Dr. G Venkatasubramanian of terminally differentiated cells in therapeutic strategies. The (Intramural NIMHANS seed money grant) investigators established simple and reproducible protocol to routinely produce highly homogeneous cultures of neural progenitors, Induced pluripotent stem cells (iPSCs) can provide a platform as an which organize into neural tube-like rosettes when they are plated in vitro patient-specific disease model to understand etiology of rare on appropriate ECM for terminal differentiation. The cell survival, and/or complex diseases and develop novel therapeutic interventions. proliferation, ROS generation and basal Ca2+ and intracellular Ca2+ Schizophrenia (SZ) is one such disease where the clinical disposition influx under stimulation were estimated for both OGD phase and is diagnosed during late adolescence but the predisposition and reperfusion phase of hypoxic-ischemic injury. Further experiments initiation is believed to be earlier during childhood due to an are in progress to assess the effect of HIE on oligodendroglial aberrant neurodevelopmental condition. Therefore, an individual, differentiation of the NPs obtained. patient-specific, cell-based disease model is critically needed for high throughput screening that may help in identifying new Cell survival of the NPs was measured through flow cytometry using therapeutic strategies for treatment of the disorder. Conventionally, Annexin/PI assay.
National Institute of Mental Health and Neuro Sciences 125 Annual Report 2015-2016
decrease in resting vesicles (VMAT2) and vesicular dopamine release are not attributable to apoptotic cell death and occur concomitantly with the phosphorylation of α-synuclein. The neuro-regulatory role of dental pulp stem cells (DPSCs) in the cellular pathogenesis of this disease is under investigation. Experiments related to evaluate the neuroprotection through DPSCs are in progress.
17. Hereditary spastic paraplegia: An enigma from clinical-
Represents the scatter plot analysis through FACS for live cells, necrotic genetic signatures to patient-derived cellular models for cells, and early and late apoptotic cell population at different time points of disease mechanisms. Investigator: Dr. Bhupesh Mehta reperfusion. The control for each time point is also provided. The percentage (Funding by DST) of cells for each quadrant is mentioned in each plot.
Hereditary Spastic Paraplegia (HSP) is a group of clinically and 16. Establishing link between 6-hydroxydopamine, α-synuclein genetically heterogeneous neurological disorders characterized by and vesicular dopamine release in an in vitro Parkinson’s pathophysiological hallmark of length-dependent distal axonal disease modelto evaluate the protective effect of human degeneration of the corticospinal tracts. In this project, the HSP patient’s dental pulp stem cells. Investigators: Dr. Indrani Datta, Dr. derived cellular material will be induced to yield lymphoblastoid cells Ramesh Bhonde (Funding by ICMR) lines (LCLs) and induced pluripotent stem cells (iPS).
Using single cell patch clamp technique, the LCLs and the iPSare characterized for their Ca2+ conductance, measurement of Ca2+ activated K+ channels and the voltage gated K+ channels.
A) Representative immunofluorescence imagesof control and 6-OHDA treated SH-SY5Y cells immune-labelled with a-synuclein and ubiquitin. Nucleus was counter stained with DAPI. The inset shows a higher magnification of the cell indicated by an arrow. B&C) Representative immunoblots showing the expression of a-synuclein and b tubulin III bands for control and treated cells. D&E) Represents the densitometric analysis of 419kDa and 424kDa bands of a-synuclein for control and treated cells, normalized for their respective b tubulin III expression. Relative density are shown as mean ± SEM for n=3. Significant differences from control and different 6-OHDA treatments is denoted as (*P<0.05) and (**P<0.001).
The relevance of the endogenous neurotoxin 6-hydroxydopamine Patient derived LCL cell in serum free culture media for electrophysiological (6-OHDA) in the pathogenesis of Parkinson’s disease (PD) is recordings. The LCL cell patched with a glass electrode for whole cell voltage clamp recordings. established through post-mortem analysis of PD patient’s brain- tissue and urine sample of Parkinsonian patients under levodopa 18. Roles of cytosolic HDACs in the synaptic physiology of medication. Till date findings on the effect of 6-OHDA has been excitatory neurons. Investigators: Dr. Bhupesh Mehta, Dr. confined to the reports of increase in ROS and mitochondrial damage Preeti G Joshi leading to apoptosis. But its effect on the key clinical features like α-synuclein aggregation and phosphorylation, resting vesicular Histone deacetylases (HDACs) are a group of enzymes that pool and vesicular dopamine release is still not reported. Here, the deacetylate nuclear histones. HDACs also regulate more than 50 investigators aim to find the influence of 6-OHDA on α-synuclein non-histone proteins that include proteins known to be important for phosphorylation, resting vesicles and vesicular dopamine release. The signal transduction and neurotransmitter release. Of the known 18 relative distribution of phospho α-synuclein129+ cells in apoptotic isoforms of HDACs, several isoforms show cytosolic and dendritic and non-apoptotic populations at different 6-OHDA concentrations expression and few of these isoforms have been reported to shuttle was further assessed along with changes in oxidant-antioxidant between the cytosol and the nucleus in response to physiological cues, system, mitochondrial membrane-potential and intracellular-Ca2+. like calcium signaling. In recent years, HDAC inhibitors have shown The data suggest that at sub-lethal 6-OHDA concentrations, the
126 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 therapeutic potential for the treatment of severe leukemia, and have from rats of different postnatal ages (15-30D, 2-3M and 10-12M). also been explored as novel therapeutics for the treatment of several The investigators found age and region specific differences in neurological disorders. With the ubiquitous expression of HDACs glutamate induced calcium signaling in astrocytes. These data indicate in all body tissues, its inhibitors bring in several deleterious effects. that the properties of astrocytes in dorsal and ventral horn differ. It To reduce the non-specificity of the HDAC inhibitors activity, it is appears that the astrocytes in the ventral horn have a weaker glutamate important to understand the function of independent HDAC isoform. handling capacity which may contribute to greater excitotoxicity in motor neurons. In this project, the focus is on the role of cytosolic HDACs in the pre and post synaptic functions of excitatory hippocampal neurons. 20. Structural and functional analysis of therapeutic proteins, The HDAC isoforms under study include Type II class of HDACs Sirtuins and SOD1 associated with neurodegenerative (HDAC4, 5, 6, 7, 9, and 10) and few isoforms of the Types I class. diseases. Ms. Manjula Ramu (CSIR SRF Fellow). Guides: Dr. B Padmanabhan, Dr. Srinivas Bharath MM (Funding by DST)
Neurodegeneration is the progressive loss of structure and function of neurons, leading to the death of neurons. Neurodegeneration results in development of Parkinson’s, Alzheimer’s, and Huntington’s diseases. Different neurodegenerative disorders (ND) include atypical protein assemblies and oxidative stress which lead to cell death. Since Representative immunofluorescence image of HDAC isoforms (HDAC 4, 5, the proteins such as Sirtuins and Superoxide dismutase 1 (SOD1) are and 6) in primary hippocampal mixed neuron astrocyte culture. directly or indirectly involved in the abovementioned disorders they have grabbed the global attention in drug targeting. 19. Neuron-astrocyte interaction in relation to excitotoxicity in spinal neurons. Ms. Shiksha Sharan (DST Inspire Fellow). The increased expression of SIRT1 in ND helps in treating the Guides: Dr. Preeti G Joshi, Dr. A Nalini, Dr. Bhupesh Mehta symptoms. The regulation of SIRT1 activity can be achieved by its (Funding by DST) interacting proteins such as DBC1, USP22, AROS and etc. The understanding of interaction mechanism would help in developing Glutamate induced excitotoxicity has been recognized as a major a better strategy to treat ND. In this regard interactors of SIRT1 factor contributing to progressive degeneration of motor neurons are cloned and expressed in a bacterial system to get pure protein in Amyotrophic lateral sclerosis (ALS). L-Glutamate effectuates its for structure-function analysis. Various clones of SIRT1 and SIRT2 actions by 3 subtypes of glutamate receptors i.e., AMPA, NMDA, proteins were expressed in E-coli and purified protein was used kainate receptors. The extracellular level of glutamate is maintained for crystal screening. In-silico analysis was performed and virtually with high fidelity via glutamate transporters viz. EAAT1, EAAT2 screened few drug molecules that can inhibit the SIRT1 activity. The and EAAT3. Astrocytes actively participate in neuro-modulation validation of these small molecules for its inhibition will be done by and excitability by special transporters and receptors present on deacetylation assay. their membrane; they play a role in glutamate homeostasis at synapse by synthesis, release and uptake of glutamate. In the spinal In addition, SOD1 was also produced in large scale for the structural cord the motor neurons are located exclusively in the ventral horn. analysis. Since the dimerization stabilization plays a major role in ALS, To understand the selective vulnerability of motor neurons in ALS some of the small molecules will be checked for SOD1 stabilization. the glutamate handling properties of astrocytes in the ventral and SOD1 apo crystals that were obtained from pure protein were used for dorsal horns of rat spinal cord have been investigated. The results X-ray diffraction and structural analysis. with immunohistochemical staining demonstrate that the expression of glial glutamate transporters EAAT1 and EAAT2 in the ventral 21. Structure based approach to discover and develop potential horn is much less compared to dorsal horn and it further reduces in inhibitors for the BRD2 bromodomains and delineate their higher age groups. On the other hand neuronal glutamate transporter effects in neurodegenerative models. Ms. Shruti Mathur EAAT3 exhibited higher expression in ventral horn neurons as (DST-WoS Fellow). Guide: Dr. B Padmanabhan (Funding compared to the dorsal horn except in 2-3 month old animal. The by DST and DBT) expression of GluR2 subunit of AMPA receptors which renders glutamate receptors calcium impermeability was also less in ventral The BRD2 protein, which belongs to the BET Family, is a potential horn. The region and age specific differences in functional activity therapeutic target for neurological disorders. The aim of the of glutamate receptors was investigated in astrocyte cultures prepared investigators is to obtain small molecule inhibitors for BD1 and
National Institute of Mental Health and Neuro Sciences 127 Annual Report 2015-2016
BD2 bromodomains of BRD2 by rational drug discovery approach. 3. Statistical analysis to study the factors of co-dependency. Ms. They have obtained initial hits from the NCI Diversity III library. Anju Jacob. Guide: Dr. Mariamma Philip The selected compounds were validated by molecular dynamics (MD) simulation studies. Co-dependency is an emotional and behavioural condition that affects an individual. In the current study, researcher attempted to 22. Structure based drug discovery of potent keap1 inhibitors: compare the factors of codependency between women living with A new therapeutic target in neurodegenerative disease. Mr. alcoholic and non-alcoholic husbands, to correlate the various factors Prashant Deshmukh, JRF. Guide: Dr. B Padmanabhan of codependency and to employ multiple linear regression analysis to (Funding by DST and ICMR) predict self-esteem-a major factor of codependency. It was seen that factors of codependency differed significantly among women living The maintenance of cellular homeostasis is vital for the cells to with alcoholic and non-alcoholic husbands. Factors such as setting function normally and efficiently. Disturbance of this balance leads personal boundaries, self-concept, acknowledging ones needs and to various pathophysiological states. The transcription factor Nrf2 wants and compulsivity were found to be significant predictors of self- is an essential part in cells cytoprotective mechanism and its level esteem among wives of alcoholic husbands. is maintained by an adaptor protein Keap1, which is a negative regulator of Nrf2. Thus, Keap1-Nrf2 interaction inhibition is important drug targetin many diseases including neurodegenerative Child and Adolescent Psychiatry diseases. In this contest, the investigators expressed and purified both Chitin-tag Keap1 and His-tag Keap1 to obtain highly purified 1. Neuro-anatomical and cognitive correlates of short-term Keap1. By using rational drug design approach, they discovered course and outcome of childhood and adolescent psychoses small molecule inhibitors of Keap1-Nrf2 interaction. From virtual and bipolar disorder. Investigators: Dr. Shoba Srinath, Dr. screening and docking studies, some potential hit compounds Mariamma Philip (Funding by CEIB) from the NCI Diversity Set 3 have been obtained.The selected compounds were tested by fluorescence polarization (FP) assay, to 2. Autism and epilepsy – an exploration of a relationship. find their inhibition effect on the mKeap1-Nrf2 complex. From this Investigators: Dr. Shoba Srinath, Dr. Satish Girimaji, Dr. study, the investigators have identified some potential inhibitors of Shekhar Seshadri, Dr. John Vijay Sagar, Dr. Preeti Jacob, Dr. Keap1-Nrf2 system. Keap1 crystal structure determination and co- P. Satish Chandra, Dr. Sanjib Sinha, Dr. Shivshankar, Dr. crystallization studies are in progress. Yamini, Dr. SS Meera, Dr. Mariamma Philip (Funding by ICMR)
Biostatistics The project was initiated on 25th March 2015. The initial few weeks were invested in training of the staffs and procurement of materials. 1. Structural equations modeling approach to study A proforma for the study was also finalized during this period. The latent relations among clinical, immunological and recruitment process started in July 2015. The initial 10 cases were Neuroimaging parameters in Schizophrenia. Investigators: taken as a pilot study. A total of 120 patients were contacted, out of Dr. DK Subbakrishna, Dr. Mariamma Philip, Dr. G which 55 cases have been recruited into the study, which included 43 Venkatasubramanian (Funding by DBT) cases of ASD without epilepsy and 12 cases of ASD with epilepsy. A total of 31 cases have been fully completed. A total of 40 EEG, 49 2. Applications of multilevel modelling in health research. Ms. speech and language assessments and 45 psychological assessments Nidhi Menon. Guide: Dr. B Binukumar have been completed so far. Patient recruitment process is in progress.
Multilevel modelling is a statistical technique that extends ordinary 3. Imaging and biochemical correlates in children with autism regression analysis to the situation where the data is hierarchical. It with and without epilepsy. Investigator: Dr. K John Vijay takes into account the dependency of the observations. Evoking the Sagar, Dr. Satish Girimaji, Dr. Shekhar Seshadri, Dr. Shoba independence assumption for such data leads to invalid inferences Srinath, Dr. Preeti Jacob, Dr. John P John, Dr. Chandrajit as the precision for the effects are often under estimated. This study Prasad, Dr. Mariamma Philip, Dr. Sonia Bansal, Dr. Rita aims to illustrate the importance of using multilevel modelling by Christopher (Funding by ICMR) identifying the factors influencing human immune virus (HIV) infection in India by means of the National Family Health Survey-3 The recruitment process started in July 2015. The initial ten (10) cases data. Further the estimation of Intra-cluster correlation coefficients were taken as pilot study. Currently, the investigators have assessed for factors influencing prevalence of HIV in India 70 cases for eligibility. Out of which, 47 cases have been recruited.
128 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Eleven subjects among the 47 cases have ASD with epilepsy and the Dr. K John Vijay Sagar, Dr. Shoba Srinath, Dr. Satish remaining 36 have ASD without epilepsy. Overall, a total of 37 cases Girimaji, Dr. Shekhar Seshadri have been fully completed. A total of 37 MRIs and 41 biochemical investigations which include Serum Ammonia, Serum Lactate, A total of 78 children were screened initially and 50 children out of Tandem Mass Spectroscopy and Urine for abnormal metabolites have them were included in the study at baseline and were diagnosed to been completed so far. have ODD as per DSM-IV-TR diagnostic criteria. The follow-up rates were 92% (N=46) for the sixth week assessment and 90% (N=45) 4. Community child and adolescent mental health service for 12th week assessment. projects. Investigator: Dr. Shekhar P Seshadri (Funding by Department of Women & Child Development, Govt. of Of the sample, 87% of children continued to have ODD at 12 weeks and Karnataka) 13% remitted. Treatment as usual in clinical setting showed significant improvement in children and adolescent with ODD over 12 weeks. With a view to addressing child and adolescent mental health service needs and gaps, the project aims to extend child and adolescent 9. A clinical study and short term outcome of children and mental health service coverage, particularly to cover those who are adolescents with history of child sexual abuse. Dr. Sowmya most vulnerable. Project implementation entails a comprehensive Bhaskaran T S., DM. Guides: Dr. Shekhar P Seshadri, Dr. plan to provide community-based child and adolescent mental Shoba Srinath, Dr. Satish C Girimaji, Dr. K John Vijay Sagar health promotive, preventive, and curative care in urban and later in rural sites through direct service delivery and training and capacity The primary aim of the study was to examine the clinical characteristics building of child care workers from community-based governmental and course, outcome of children with history of CSA over 12 weeks. and non-governmental agencies/institutions and professionals, Twenty nine children with history of CSA were compared to 29 including schools, NGOs, anganwadis and health workers. The controls without history of CSA. The commonest diagnosis in specific objectives of the project include: (i) Establishment of children with history of CSA was Depressive Disorder followed community-based child and adolescent services; (ii) Training by Post-Traumatic Stress Disorder. Older age, male gender, longer and capacity building of childcare workers and staff from various duration of abuse, abuse by multiple persons, threats during abuse was governmental and non-governmental agencies, including associated with higher baseline severity. The course and outcome has schools; (iii) Draw from implementation experiences to develop been favourable and the condition of the children with history of CSA a comprehensive community child and adolescent mental health improved significantly in all measures. service model that may be replicated elsewhere in the country. The first year of the Community Child and Adolescent Mental Health 10. Brief in-patient intervention study of children with Autism Service Project has ended. Spectrum Disorder: Formalizing an intervention package. Dr. Pooja Panchal. Guides: Dr. Shoba Srinath, Dr. Satish 5. Role of genetics in autism spectrum disorder with or without Girimaji, Dr. Shekhar Seshadri, Dr. John Vijay Sagar epilepsy. Investigators: Dr. Satish C Girimaji, Dr. Shoba Srinath, Dr. John Vijay Sagar, Dr. Sanjiv Jain, Dr. Meera Autism spectrum disorder (ASD) refers to neuro-developmental Purushothaman, Dr. Subbakrishna (Funding by ICMR) disorder characterized by persistent deficits in social communication and social interaction and repetitive pattern of interests and behaviour. Most 6. Study of neural development in a human induced successful programs for ASD include a parent training component. Pluripotent Stem cell (hiPS) model of primary microcephaly There has been significant increase in the number of cases diagnosed (Collaborative Project). Investigators: Dr. Shyamala Mani, of ASD in NIMHANS. In this context, the present study has been Centre for Neurosciences, IISc., Bangalore, Dr. Satish undertaken to formalize the already existing interventions into a package Girimaji (Funding by IRHPA, DST) for children and adolescents with ASD and to examine the effect of the package by implementing it on 20 families of children with ASD. 7. Whole exome sequence analysis to identify novel causative genes for primary microcephaly in Indian families 11. A study of eye movements in Juvenile-onset obsessive (Collaborative Project). Investigators: Dr. Arun Kumar, compulsive disorder. Dr. Anirban Ray. Guides: Dr. K John Dept of MRDG, IISc., Bangalore, Dr. Satish Girimaji Vijay Sagar, Dr. Satish Girimaji, Dr. Shoba Srinath, Dr. (Funding by SERB, DST) Sekhar Sheshadri, Dr. G Venkatasubramanian
8. Factors affecting outcome in oppositional defiant disorders: a This study examined eye movements in pro-saccade and anti-saccade 3 month prospective study. Mr. Raghunandan Mani. Guides: tasks in pediatric OCD through noninvasive, non-contact state of
National Institute of Mental Health and Neuro Sciences 129 Annual Report 2015-2016 art machine in a laboratory setting through a camera and computer. 15. Life skill based intervention for children and adolescents in A total of 36 cases and 31 controls were recruited for this study. school bullying. Ms. Megha Mahajan. Guides: Dr. Shekhar Eye movement parameters were not different in cases compared to P Seshadri, Dr. Shoba Srinath, Dr. Satish Girimaji, Dr. John controls. Age related trends in parameters were different in cases VS, Dr. Preeti Jacob and controls in ‘gain’ and ‘velocity’ related parameters. ‘Gain’ related parameters also varied with severity. Secondary analysis showed School bullying is increasingly being reported in children and uncorrected errors in anti-saccade task, inversely proportional with adolescents in school. It has significant impact on their psychological school and academics related performance. health and overall development. Victims of school bullying have been seen to lack certain basic life skills making them more susceptible to 12. Follow up study of children and adolescents diagnosed with school bullying. Hence the study has been planned to empower them attention deficit hyperactivity disorder. Ms. Rani Jancy AR. with life skills over six sessions. Also their experiences and changes Guides: Dr. Shobha Srinath, Dr. Satish C Girimaji, Dr. would be studied and analysed. Shekhar P Seshadri, Dr. John Vijaya Sagar 16. A qualitative study of self-cutting in shelter homes for The study evaluated the clinical status and functionality of children children. Dr. Rajendra KM. Guides: Dr. Shekhar P Seshadri, and adolescents diagnosed with ADHD as a part of an earlier study Dr. ShobaSrinath, Dr. Satish Chandra Girimaji, Dr. K John done 24-42 months ago. Information on 77.8 % of subjects from Vijay Sagar, Dr. Preeti Jacob, the original study sample was obtained. Of them 67.4% came for a face-to-face interview, 30.6% were interviewed on telephone and The study aims at understanding self-cutting behaviour in shelter in 2% information was extracted from a recent file entry. 17.8 % of home children, which tends to occur at high rate in this population the subjects did not meet the clinical diagnosis of ADHD in the and consequently care-takers in shelter home face difficulty in follow-up. Global functioning of subjects improved significantly providing help and care for these children. The investigators are in the follow-up irrespective of medication adherence and type of aiming at understanding the behaviour from three different subjective management. perspectives, that is, from children who engage in self-cutting, from children who are living in shelter homes but do not engage in any 13. Use of transcranial direct current stimulation (tDCS) in form of self-Injurious behaviour and from care-takers of shelter home child and adolescent onset Psychotic disorders: Evaluation of who take care of the children. They are also hoping to develop a model tolerability and clinical utility. Dr. Vinayak Koparde. Guides: to understand the self-cutting and a manual to deal this problem at an Dr. Satish Chandra Girimaji, Dr. G. Venkatasubramanian, individual and a systemic level. Dr. Shoba Srinath, Dr. Shekhar P Seshadri, Dr. K. John Vijay Sagar, Dr. Preeti Jacob 17. A comparative study of children diagnosed with autism spectrum disorder with and without regression. Dr. Siddeswara In this prospective study, the investigators attempt to measure the BL. Guides: Dr. Shobha Srinath, Dr. Preeti Jacob, Dr. Satish C tolerability and effect of tDCS on overall psychopathology of children Girimaji, Dr. Shekar P Sheshadri, Dr. John K Vijaysagar and adolescents with Schizophrenia and other Psychotic disorders in an open label design. Twenty subjects, aged 6-18 years, with ICD-10 Autism spectrum disorder is a neurodevelopmental disorder. A diagnosis of Psychosis and related disorders with partial response or no smaller group of ASD children lose skills overtime. The goal of this response to at least one antipsychotic treatment will be administered study is to compare children diagnosed Autism Spectrum Disorder 10 sessions of tDCS for five days. (ASD) with history of regression to children without regression. Children diagnosed with ASD at CAP services at NIMHANS were 14. Study of factors affecting short term outcome of depression taken after scrutinizing through the predefined criteria. The children in children and adolescents. Dr. Syed Karar Hussain. Guides: are being screened for regression and then moved into either group of Dr. K John Vijay Sagar, Dr. Shoba Srinath, Dr. Shekhar P ASD with or without regression, followed by assessments of different Seshadri, Dr. Satish Girimaji, Dr. Preeti Jacob variables. Study is currently ongoing.
The study will look into the factors affecting short-term outcome 18. A follow up study of treatment emergent side effects in children of depression in children and adolescents. It will be a prospective and adolescents started on SSRI. Dr. Arul Jayendra Pradeep V. study wherein subjects fulfilling inclusion criteria shall be recruited Guides: Dr. Preeti Jacob, Dr. Satish C Girimaji, Dr. Shekar P and assessment carried out at base-line and after 6, 12 and 24 weeks Seshadiri, Dr. Shoba Srinath, Dr. Jhon Vijay Sagar interval under naturalistic treatment at usual settings. Data will be statistically analyzed to meet the objectives of the study. This study aims at identifying treatment emergent side effects
130 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 in children and adolescents on SSRI with focus on studying 3. Study of functional connectivity in early Alzheimer’s suicidality, behavior activation profile and general side effects with Dementia. Dr. Rakesh B. Guides: Dr. Srikala Bharath, Dr. a baseline assessment and follow-up assessment every two weeks Sanjeev Jain, Dr. John P John, Dr. Keshav K till 12 weeks. 4. Respiratory chain disorders in children – Genotypic, 19. Clinical profile and development of intervention package for phenotypic and functional correlation. Dr. Sonam Kothari. children and adolescents with primary headache syndromes. Guides: Dr. PS Bindu, Dr. Gayathri N, Dr. MM Srinivas Dr. Sreyoshi Ghosh. Guides: Dr. Satish Girimaji, Dr. Shoba Bharath, Dr. K Thangaraj Srinath, Dr. Shekhar P Shesadri, Dr. John K Vijay Sagar, Dr. Preeti Jacob This study analyzed the phenotypic spectrum and their correlation with respiratory chain enzyme deficiency and genotype in a cohort In this study, children presenting with migraine and tension type headache of 85 children. Respiratory chain assay by spectrophotometry was (TTH) between the ages of 8-15 years who are not on prophylactic standardized. The most common deficiency was complex 1 (60%) medication will be included. The purpose of this study is to assess the followed by multiple complex deficiencies (27%), complex IV(9%) quality of life and associated conditions in children and adolescents and complex III deficiency (4%). Children with complex1 deficiency presenting with migraine and TTH. Additionally, the investigators will exhibited a wide variety of phenotypes and disease course. Leigh’s be designing and offering a psychological and behavioral intervention syndrome with COX deficiency and SURF1 mutation formed package without any medication for these children. the major group among patients with complex IV deficiency. Genotypic phenotypic and functional correlations suggested that the respiratory chain enzyme assays improved the diagnostic Clinical Neurosciences certainty in a large number of patients especially those with non- syndromic presentations in comparison to histopathological and 1. A study of inflammatory markers and heart rate variability in genetic studies. severe head injury. Dr. Akhil Deepika. Guides: Dr. B Indira Devi, Dr. Dhaval P Shukla, Dr. Rita Christopher, Dr. TN 5. Adenosine signaling pathway in medically refractory epilepsy Sathyaprabha due to mesial temporal sclerosis (MTS) lesions. Dr. Vikas Dhiman. Guides: Dr. Sanjib Sinha, Dr. Satishchandra, Dr. A prospective exploratory study was done with a sample size of 89 Anuranjan Anand, Dr. Anita Mahadevan, Dr. Arivazhagan severe traumatic brain injury patients. The Heart rate variability of A (Partial funding by ICMR) these patients was recorded using a telemetric device BioHarness (Zephyr technologies). The recordings were made on day one of the The aim of the present study was to understand the role of adenosine patients’ admission into the ICU followed by serial recordings on day signaling pathway in medically refractory epilepsy due to mesial three and day 10. Serum samples of the patients were also collected temporal sclerosis. A comprehensive analysis of this pathway was on these days. They were analyzed for the IL-1β, IL-6, IL-10 and conducted by studying 10 most critical genes involved in this pathway TNF-α using ELISA kits. The outcome assessment was done based in the surgically resected hippocampal tissues and age and gender on Disability Rating Scale (DRS) values at discharge and Glasgow matched control tissues (autopsy tissues). In the present study, both Outcome Scale Extended (GOSE) values observed at the sixth month pre- and post-surgery blood samples were studied and compared with post trauma. The data set was analysed by grouping the patients on the control blood samples. This is said to be the first such study, which the basis of mortality and their outcome. In the present study, it was has comprehensively evaluated various steps in adenosine signaling evidenced that there was significant subclinical autonomic dysfunction pathway in MTS. in patients with severe TBI. Among the serum cytokines, the levels of IL-10 had significant impact on the outcome. An increase in its levels This study conclusively demonstrated that all the ten genes correlated with the unfavorable outcome. This study highlights the contribute to the pathogenesis of MTS by either up regulating or association between the HRV parameters and the immune response. down regulating their expression. More targeted inferences could be The timely management of both autonomic and immune dysfunction obtained from adenosine specific genes (ADK, ADORA, NT5E and in the patients of severe TBI can have a greater impact in preventing ADARB1) as compared to genes like c-myc, c-ju, CREB1, NF-kB1 the secondary injury process. and MAPK1, which could be influenced a number of non-specific pathways in the neuron. Comparing the gene expression analysis 2. Molecular genetic basis of radiation resistance in in the blood highlighted various molecules, which could be used as glioblastoma. Dr. Arun HS. Guides: Dr. SS Sampath, Dr. potential biomarker of epilepsy in the blood. One of the key aspects Vani Santosh, Dr. Arivazhagan A of the present study was the analysis of gene expression during the
National Institute of Mental Health and Neuro Sciences 131 Annual Report 2015-2016 pre-surgery and post-surgery seizure free period. This unique strategy activity demonstrates an increased neuronal coupling in epileptic gave novel results, which could be further translated in to biomarkers foci and is thought to be a manifestation of the perpetual synaptic with potential translational clinical applications. Correlation of gene remodeling occurring within these brain networks. expression findings with various clinical features of the patients revealed interesting observations that enhance the understanding of This study evaluates the macro and microstructural sleep pathogenesis of drug resistant epilepsy and various co-morbidities characteristics of PWE, which are reliable biomarkers of sleep associated with it. quality and arousal fluctuations in sleep, respectively. Further, the investigators use background electroencephalography (EEG) epochs and IEDs during wake and different stages of sleep in PWE and healthy controls as paradigms to understand neo-cortical dynamics involved in synchronization during the various states of vigilance in neuronal ensembles. This can in turn improve the understanding of the sleep and epilepsy interrelationship.
8. Role of renin-angiotensin aldosterone system in cognitive deterioration in patients with cerebral small vessel disease. A: Western blot of NF-kB1 in control (CT23) and tests (PT9, PT25) Dr. Thomas Gregor Issac. Guides: Dr. SR Chandra, Dr. Rita B-D (C control – CT23): Localization of NF-kB1 was seen in neurons of dentate Christopher, Dr. Jamuna, Dr. Mariamma gyrus (DG) (B) and temporal cortex (C) in the temporal cortex with labelling of few glia cell nuclei (D). E-H (Test – PT25): Whole mount of hippocampus shows intense labelling of Cerebral small vessel disease is a term which encompasses white hippocampal Ammons horn and diffuse labelling of temporal cortex (E). Close up view(PT3) revealed intense neuropil labelling of the dentate gyrus and few matter hyper intensities, lacunar infarcts and micro bleeds which are Ammons horn neurons (F) while the dentate granule neurons are spared. In seen in MR imaging. The Renin-Angiotensin-Aldosterone System the temporal cortex, pyramidal cortical neurons (G) and glial cells in white matter (H) showed intense cytoplasmic localization in addition to labelling (RAAS) is an important auto regulatory system maintaining Blood the neuropil pressure homeostasis. RAAS in cerebral small vessel disease, which is the most important cause of Vascular dementia and vascular 6. Exploring subclinical cerebellar dysfunction in patients depression has not yet been fully studied. The rationale behind with essential tremor, primary writing tremor and writer’s this study is to identify the role of the RAAS system in progression cramp by quantitative characterization of ocular movements of benign SVD to Vascular dementia as almost 94% of the healthy and eye-hand coordination and advanced neuroimaging population above 60 years of age have cerebral small vessel changes techniques. Dr. Ketan Jhunjhunwala. Guides: Dr. Pramod in MR imaging while only one third of them progress into cognitive Kumar Pal, Dr. AK Gupta, Dr. K Thennarasu, Dr. Jitender decline. The aim is to characterize the phenotypic aspects of this Saini, Dr. Ravi Yadav disease, to assess the gene polymorphisms in the pathway, to correlate with serum aldosterone levels and to determine the pattern 7. Macro and microstructural video-polysomnographic signal of cognitive involvement in the illness. The levels of Aldosterone, analysis: sleep and epilepsy correlation. Dr. Chetan S Nayak. ACE activity as well as the 5 polymorphisms described in RAAS Guides: Dr. Sanjib Sinha, Dr. AB Taly, Dr. K Thennarasu, axis will be studied and the cognitive deterioration will be assessed Dr. Kaushik Majumdar by appropriate neuropsychological tests prior and a year later. This will help in ascertaining the role of these polymorphisms in the Patients with epilepsy (PWE) have several disturbances in sleep natural course of the illness as well as throw a light on the role of architecture that occur despite the absence of daytime-seizures drugs especially antihypertensives acting on this pathway which and antiepileptic drugs (AEDs). This is suggestive of inherent may have potential to prevent this cognitive deterioration in the sleep instability in the epileptic brain. Arousal instability during long run. sleep not only contributes to sleep disorganization but also acts as a potential trigger to activate of epileptiform activity. Consequently, 9. Simultaneous EEG FMRI to study phase synchronization the occurrence of epileptiform activity during sleep can further hinder and functional connectivity in symptomatic localization sleep continuity and worsen arousal instability, causing a vicious cycle related epilepsy. Dr. Ganne Chaitanya. Guides: Dr. Satish of poor sleep quality and intractable seizures. On the other hand, Chandra, Dr. Sanjib Sinha, Dr. Rose Dawn Bharath the changes in the strength of cortical synchronization gives us an overview regarding the nature of coupling in the brain during sleep 10. Austism Spectrum Disorders – Role of oxytocin and imaging and wake periods alongside the occurrence of inter-ictal epileptiform analysis. Dr. Sowmyashree. Guides: Dr. Shoba Srinath, Dr. discharges (IEDs). The rise in cortical synchronization during seizure Satish Chandra Girimaji, Dr. Rose Dawn Bharath
132 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
There are two major parts in this study: The first part involves them to cut down drinking and improve clinical outcome in patients. estimation of oxytocin levels in blood and salivary samples of children The study would help in providing answers to the ambiguous questions with ASD and salivary samples from their mothers. The second part about inhibitory control training influencing the alcoholism by use of involves finding structural and metabolite abnormalities in the brain, experience sampling method with smart phones. focusing on anterior cingulate cortex, and looking for correlation with oxytocin levels. The investigators will also be trying to study the 15. Neural oscillations as biomarkers of epileptogenic zone. Dr. correlation of the neurodevelopmental factors and neuropsychiatric Velmurugan J. Guides: Dr. Sinha S, Prof. Satishchandra P, symptoms, severity of the disease and comorbidities with the oxytocin Prof. Srikantan Nagarajan levels and imaging findings. 16. Identification of biomarkers for psychosis in Parkinson’s 11. Vitamin D and immune dysfunction in Autism Spectrum disease by advanced neuroimaging retinal imaging, Disorder. Dr. Salah Basheer. Guides: Dr. Satish C Girimaji, neuropsychological profile and genetic polymorphism studies. Dr. Ravi V Dr. Abhishek Lenka. Guides: Dr. Pramod Kumar Pal, Dr. Rita Christopher, Dr. A Shyamsundar, Dr. Jitender Saini, Dr. 12. Nuclear mitochondrial intergenomic communication Shantala Hegde disorders - a phenotypic, pathological, biochemical and genotypic study. Dr. Shwetha Chiplunkar. Guides: Dr. PS Parkinson’s disease (PD) is a progressive neurologic disorder Bindu, Dr. AB Taly, Dr. Gayathri N, Dr. Meera Purushottam characterized by tremor at rest, bradykinesia, postural instability and rigidity. In addition, patients with PD may also develop non- Mutations in genes involved in mitochondrial replication and motor symptoms. Psychosis is one of the debilitating non-motor maintenance can disrupt the integrity of the mitochondrial genome symptoms of PD and is an independent risk factor for nursing causing nuclear-mitochondrial intercommunication disorders. home placements, caregiver burden and mortality in patients with Multiple deletions and depletions of the mtDNA or a combination PD. Hence identification of patients who are prone to develop of both phenomena in critical tissues are the hallmarks of these psychosis is of paramount importance. This study aims at identifying disorders. As part of this ongoing study, multiple deletions such patients using a multimodal approach using advanced in the muscle mitochondrial DNA was analyzed in a cohort of neuroimaging, retinal imaging using optical coherence tomography, 330 patients. Large single deletions and multiple deletions were genetic polymorphism studies (IL-6, COMT, HOMER1) and identified in 60 patients suggesting that defective mitochondrial neuropsychological evaluations. DNA maintenance may be the underlying cause of mitochondrial dysfunction in large number of patients with mitochondrial 17. Clinical spectrum and immunobiology of Neuromyelitis disorders. optica. Dr. Harikrishna B. Guides: Dr. P Satish Chandra, Dr. V. Ravi, Dr. Nethravati, Dr. Manjunatha, Dr. Anita 13. Epigenetic study in alcohol dependence. Dr. Soundarya. Mahadevan, Guides: Dr. Pratima Murthy, Dr. Meera Purushottam, Dr. Arpana Agrawal The study aims to understand clinical profile and immunological basis of demyelinating diseases especially multiple sclerosis and The investigator aims to study the gene-environment interactions in neuromyelitis optica. The patients suffering from demyelinating chronic alcohol use; DNA methylation and gene expression changes autoimmune diseases will be evaluated clinically to establish the associated with chronic alcoholism and its interactions with one diagnosis with proper investigative procedures, subsequently their carbon metabolism genes will also be studied. The study will provide blood parameters for immune cells which are believed to cause of insight on epigenetic changes associated with chronic alcoholism and disease will be studied. This study will help in understanding and its association with relapse mechanisms. management of autoimmune diseases which are increasing in our country. 14. Inhibition training and electrophysiology in alcohol use disorder. Dr. Mrunal Bandawar. Guides: Dr. Vivek Benegal, 18. Exploratory study- In search of retinal neurovascular unit Prof. Matt Field, Dr. J Keshav Kumar, Dr. Paul Christianson markers in AD. Dr. Ravi Teja. Guides: Dr. Mathuranath, Dr. (Dual PhD programme, NIMHANS-University of Hima Pendharkar, Dr. Praveen R Murthy, Dr. Keshav, Dr. Liverpool) Tos Berendschot
The aim of the study is to develop a smart phone training game to The study aims to identify new retinal neurovascular unit markers improve inhibitory control in alcohol affected population, helping in Alzheimer’s disease, using automated software (Lie Analysis)
National Institute of Mental Health and Neuro Sciences 133 Annual Report 2015-2016 for objective estimation. As retina is the window to the brain, the The study focusses on using genetic, proteomics and advanced investigators are focusing on development of new noninvasive retinal neuroimaging techniques such as voxel-based morphometry, diffusion markers. tensor imaging and resting state functional MRI to examine genotype phenotype correlation in SCA2 and variability in SCA2 19. Quantitative magnetic resonance imaging of brain in duchenne muscular dystrophy. Dr. Preethish Kumar 23. Study of sleep architecture, cognition and neurochemical V. Guides: Dr. Nalini A, Dr. Jamuna Rajeshwaran, Dr. correlates in Parkinson’s disease and other atypical Jitender Saini parkinsonism. Dr. Ragasudha Botta. Guides: Dr. Ravi Yadav, Dr. Pramod K Pal, Dr. Anita Mahadevan, Dr. Bindu Kutty, 20. Mitochondrial DNA copy number variation in Dr. Keshav Kumar Glioblastoma and its effect on sensitivity to radiation and chemotherapy- a clinical-molecular characterization. The study attempts to evaluate the changes in macro and micro Dr. Sravya Palavalasa. Guides: Dr. Sampath S, Dr. Vani sleep architecture in patients with Parkinson’s disease (alpha Santhosh, Dr. Arivazhagan A synucleinopathy) and Atypical Parkinsonism (progressive supranuclear palsy/corticobasal syndrome-tau pathology), compare and correlate Mitochondrial DNA copy number has been studied and incriminated the sleep parameters in Parkinson’s disease (alpha synucleinopathy), in various cancers, but not in Glioblastoma. Mitochondria contain Progressive Supranuclear Palsy/Corticobasal syndrome (taupathy) multiple circular double stranded DNA (mtDNA) which code for with neuropsychological scores and alpha synuclein and tau markers 13 proteins of Electron Transport Chain. Certain nuclear genes are and explore the utility of skin biopsy in differentiating between clinical known to control the replication of mtDNA. Since altered metabolism subtypes of Parkinsonism. (Warburg effect), a hallmark of cancer cells, could result from abnormal intergenomic crosstalk, this will be investigated in Glioblastoma 24. Identification of Lithium induced molecular network by studying: (i) mtDNA copy number in Glioblastoma and its changes in Huntington’s disease. Dr. Nikhil Ratna. Guides: variation with Chemo-radiotherapy, using qRT-PCR (ii) The role of Dr. Mathew Varghese, Dr. Pramod K Pal, Ramakrishnan nuclear gene/s regulating mtDNA copy number in Glioblastoma by Kannan, Keshava Prasad studying protein expression using Immunohistochemistry (iii) The effect of mtDNA copy number on resistance to therapy by studying Using proteomic and phosphoproteomic profiling of Huntington’s sensitivity of differentially depleted (using Ethidium bromide) clones disease patient derived cell lines and tissue specifically expressed of established Glioblastoma cell lines to radiation and chemotherapy. transgenic mutant Huntington flies, the investigators aim to delineate the putative targets and the related pathways induced by mutant 21. Mutational analysis in duchenne and becker muscular Huntingtin and lithium in the disease models. dystrophy – A next generation sequencing based study with genotype-phenotype correlation. Dr. Kiran Polavarapu. 25. Immunotherapeutic potential of N-terminal fragments Guides: Dr. Nalini A, Dr. Monojit Debnath, Dr. Jamuna of Tau (NTF-Tau) in tauopathy model rats. Mr. Ganesh Rajeshwaran. Savanur. Guide: Dr. Sarada Subramanian
The study consists of three main aspects (i) application of Next Gen Presence of neurofibrillary tangles containing hyperphosphorylated Sequencing technology for identifying mutations in DMD/BMD tau is characteristic of the Alzheimer’s disease neuropathology. As patients previously undetected by MLPA technique (ii) comparing cognitive functions correlate well with the degree of tau pathology, MLPA and NGS in detecting copy number variations in DMD gene (iii) clearing these aggregates is a promising therapeutic approach. carrier status analysis in all the available mothers and sisters of probands. The aim of the proposed study was to evaluate the influence of active immunization with pathology specific phospho-tau Based on the NGS profiling of DMD gene mutations, a phenotypic epitopes on prevention of tauopathy in healthy animals and passive - genotypic correlation as well as correlation to neuropsychological immunoneutralization studies on restoration of neuronal function in parameters will be performed. the animal models of tauopathy. The results indicated that antibodies directed against N-terminal region of Tau can significantly improve 22. Genetic, proteomic and advanced neuroimaging correlates the cognitive functions in tauopathy model rats. of spinocerebellar ataxia 2. Dr. Albert Stezin Sunny. Guides: Dr. Pramod Kumar Pal, Dr. Sanjeev Jain, Dr. Rose Dawn 26. The quantitative analysis of pro-inflammatory cytokines in Bharath, Dr. Jitender Saini, Dr. Shantala Hegde, Dr. Harsh Guillain Barre Syndrome. Ms. Geetanjali M. Guides: Dr. Gowda Monojit Debnath, Dr. Taly AB, Dr. Madhu Nagappa
134 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
27. Mitochondrial DNA copy number variation in Glioblastoma Guides: Dr. Rita Christopher (Funding by DBT) and its effect on glioblastoma pathogenesis. Dr. Sravya P. Guides: Dr. Sampath S, Dr. Arivazhagan A, Dr. Vani Santosh Traumatic brain injury (TBI) is a complex injury with a broad (Funding by DST) spectrum of symptoms and disabilities. The impact on a person and his or her family can be devastating. Cognitive difficulties are very common in people with TBI. Studies have shown Neuropsychological Clinical Psychology rehabilitation to be usefulness in improving the cognitive functions and day to day functioning. Neurofeedback training is an operant 1. Developmental outcomes of children born to mothers with conditioning procedure whereby an individual modifies the amplitude, mental illnesses during pregnancy and postpartum period: frequency or coherence of the electrical activity of his/her own brain. A longitudinal study in a Perinatal Psychiatry Clinic. The aim of the present study is to examine the biochemical correlates Investigators: Dr. Thomas Kishore, Dr. Geeta Desai, Dr. T pre, post neurofeedback training (NFT) in patients with TBI. Sixty Harish, Dr. B Binukumar (Funding by ICMR) patients diagnosed with TBI according to ICD-10 (WHO, 1992) will be recruited to one of the two groups within a month of injury into 2. Mindfulness based stress reduction (MBSR) program for intervention group (neurofeedback training) and treatment as usual. type-2 diabetes: A randomized controlled trial. Investigators: The serum levels of the above will be compared before and after NFT Dr. Paulomi M Sudhir, Dr. Thennarasu K, et al. (Funding by in both groups to elucidate the biochemical mechanisms which may a Extra mural research projects in AYUSH) possible role in the recovery. The study will be helpful in administering the NFT in the early stages of TBI, indicating that along with neural 3. Parenting and socialization processes in the development of plasticity NFT augments improvement cognition and QOL. perfectionism: An inter-generational perspective of Indian youth. Investigators: Dr. Paulomi M Sudhir, Dr. Mariamma 7. A Comparative study of cognitive retraining and EEG Philip (Funding by DBT) neuro feedback training in TBI- clinical, cognitive, EEG, Biochemical, fMRI and cerebral blood flow correlates. 4. Strengthening the pyramid of mental health care in India: Investigators: Dr. Jamuna Rajeswaran, Dr. Dhaval Shukla, Development and pilot testing of a self-care intervention for Dr. Sharada Subramanian (Funding by DST- CSIR) depression. Investigators: Dr. Seema Mehrotra, Dr. Paulomi M Sudhir, Dr. Jagadisha Thirthalli, Dr. Girish N Rao Traumatic brain injury (TBI) often results in cognitive impairment. The underlying pathophysiology of this impairment The project involves development of a self-care intervention is uncertain. Neuroimaging studies have shown that TBI results e-module for those dealing with mild levels of depression. This self- in abnormalities of functional connectivity within key cognitive care interactive module would be hosted on a web-based browser. networks. These changes are correlated with cognitive performance. It would also entail telephonic assistance and mobile prompts. The Neuropsychological rehabilitation in form of neuro feedback based development phase is nearing completion. The next phase would cognitive retraining results in significant improvement in cognitive involve pilot testing of the self-care intervention program using a pre- functions resulting in better functional outcome. The investigators post follow up design. hypothesize that the improvement in cognitive function will result in improvement in structural and reorganization of cognitive 5. Achieving and maintaining excellence in sports: A positive networks demonstrated by functional magnetic resonance imaging psychological perspective. Investigators: Dr. Seema (fMRI). Patients of moderate and severe TBI with imaging evidence Mehrotra, Dr. Paulomi M Sudhir, Dr. Manoj Sharma, Dr. of isolated diffuse axonal injury will be recruited. These patients Manjula M (Funding by Dept of Youth Empowerment and will undergo baseline neuropsychological assessment with structural Sports Govt of Karnataka) and fMRI after six months. After initial assessment the patients will undergo cognitive retraining comprising 20 sessions, spanned The project involves understanding felt needs of youth in competitive over 40 days. Repeat neuropsychological assessment and MRI will sports and coaches for psychological training to enhance performance be done immediately and after six months of completion of the and maintain well-being. In addition, it aims at documenting their retraining. psychosocial concerns and perspectives in order to develop a promotive group intervention module for enabling excellence and mental health. 8. Parenting styles, Perfectionism and self-conscious emotions in young adults: A socio cultural perspective. Investigators: 6. A study of cognitive functions and biochemical correlates in Dr. Paulomi M Sudhir, Dr. Seema Mehrotra, Dr. DK traumatic brain injury. Investigators: Dr. Jamuna Rajeswaran. Subbakrishna (Funding by ICSSR)
National Institute of Mental Health and Neuro Sciences 135 Annual Report 2015-2016
The study is aimed at understanding parenting styles and domains of attention, working memory, verbal and visual learning perfectionism as contributors to self-conscious emotions such as and memory in both healthy normals as well as clinical population shame and guilt. The study was carried out on young adults aged (MCI and mild dementia patients). The finding from phase I between 18-30 using paper pencil and interview methods, which suggests that cognitive retraining programme is promising in were conducted on a sub-sample. The sample for the paper pencil improving cognitive function in healthy normals as well as clinical assessment included 300 young adults from various colleges and population including MCI and Mild Alzheimer’s disease. The work place settings. The data collection is nearing completion and Phase II of the study aims at computerising the cognitive retraining data entry is also in progress. programs loaded on a touch screen tablet for a randomised study in healthy normal population with cognitive decline as well as patients 9. Cognitive Behaviour Therapy (CBT) in partial responders with MCI and mild dementia. with OCD: A randomized controlled trial. Investigators: Dr. Paulomi M Sudhir, Dr. YC Janardhan Reddy, Dr. Suresh 12. Cell Tower Radiation: Psychosocial implications. Bada Math, Dr. K Thennarasu (Funding by ICMR) Investigator: Dr. Manoj Kumar Sharma (Funding by Science & Engineering Research Board, DST, Delhi) The study is aimed at examining the efficacy of CBT for partial responders with OCD. A sample of 100 patients will be randomized Available evidences indicate a trend toward presence of cognitive and to either CBT with pill placebo or augmentation with Risperidone and psychosocial effects associated with cell tower radiation as well as stress management. Ratings at baseline, post and follow-up sessions addictive use of cell phone. According to a recent study, 13% in the age will be carried out on symptom ratings, mood, and quality of life. It is group of 18-60 years had excessive use of mobile phones. There is a need proposed that at least 2-25 session of intervention will be delivered. to develop evidence for psychosocial correlates of cell tower radiation The study has commenced, and data collection is in progress. as well as development of screening tool for mobile phone usages. Mapping of cell towers in a residential community (sites identified in 10. Teasing experiences, interpersonal sensitivity and body east, west, north and south regions) attached to Urban Health Center image in patients with emotional disorders. Investigators: will be carried out. Radiation in each household /apartment taken for Dr. Paulomi M Sudhir, Dr. Manjula M, Dr. MP Sharma, Dr. the study will be assessed. About 2000 subjects (males/females above Mariamma P 18 years of age) staying in radiation area facing the antenna and the ground levels will be approached through door-to-door survey to assess The study is aimed at understanding the impact of teasing and the psychosocial implication of residing in cell tower radiation areas. interpersonal sensitivity on the development of body schema—such as avoidance and dysfunctional attitudes and psychological symptoms 13. Psychometric properties of difficulties in emotion regulation of anxiety, stress and depression. The study is being carried out on 70 scale in Indian population. Investigators: Dr. M Manjula, adult patients seeking treatment at the Behavioural Medicine Unit Dr. K Thennarasu. with emotional disorders. Assessments are being carried out using both paper and pencil measures. The pilot phase of the study has been The main aim of the study is to establish the psychometric properties completed and the data collection for the main phase is in progress. of Difficulties in Emotion Regulation Scale (DERS) in Indian sample. The objectives of the proposed study are to examine the factor 11. Computer assisted retraining programme to improve structure, establish the reliability, validity, and assess the emotion cognitive functions for elderly. Investigator: Dr. Keshav regulation difficulties in community sample. Sample consists of Kumar (Funding by DST) 350 subjects (aged between 18 and 50 years) from the community population selected using snow ball technique. The participants will be Normal aging is associated with cognitive decline in the domains of assessed using socio-demographic data sheet, Difficulties in emotion memory, speed of processing and executive function. Mild Cognitive regulation scale, depression, anxiety and stress scale and PANAS. The Impairments (MCI) is known to be a transition stage between data collection and coding for analysis has been completed. Analysis normal aging and dementia. About 10 to 15% of individuals with of data and report writing is in progress. MCI will develop dementia, placing a demand on caregivers and medical treatment. Specifically designed cognitive training 14. Stress management in youth: A preventive intervention. programmes are known to reduce the risk of rapid cognitive decline Investigators: Dr. M Manjula, Dr. Roopesh BN, Dr. in healthy normal elderly, individuals with MCI and dementia. Mariamma Philip (Funding by ICSSR) Improvement in cognitive function improves the quality of life; possibly delay dementia and decreases dependence. The phase I The aim of the study was to assess the prevalence of depression of the study indicated improvement in cognitive functions in the and suicidal risk and examine the efficacy of stress management
136 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 prevention programme for the youth. The sample comprised of school The objectives of the study are to carry out the mental health literacy and college students belonging to private and government schools program on depression and suicidal behaviours for teachers and to and colleges (13-19 years). The sample was selected using stratified assess the impact of the same on knowledge, attitudes and facilitating random sampling. The sample included for the exploratory study was support and help seeking among teachers. The sample would include 1428 (650 school and 778 college sample. The sample for intervention 100 teachers teaching in high schools (8-12th standard) from private was taken from three schools and three colleges (n=379). and government institutions in Bangalore. Stratified sampling with pre-post assessment single group design with a follow-up after three About 15 such sessions were carried out for the intervention group months would be adopted. in a group format at their institutions and the size of each group varied from 20-50. Post assessment was carried out in a gap of about The study will be carried out in the following phases: The questionnaires a month. The results showed that academics and family relationships for assessing knowledge and attitudes, and feedback forms to evaluate were the major areas of stress both in school and college. About the utility of the test will be developed, validated and pilot tested. The 2.8% of the adolescents in the study attempted suicide and the sessions for assessment and orientation programme will be carried most frequently used method being medication overdose. About out in group format. Each group will have approximately six-eight 30% of the sample had moderate to severe depression. After the teachers. The session duration will range from two-three hours each. brief preventive intervention there was significant reduction in Two sessions will be held for each group. Approximately about 15 suicidal ideas and attempts. Significant reduction was also seen on such group sessions will be carried out. Pre and post assessment and a depression, suicidal probability scores and improvement in coping follow up after three months will be carried out to examine the impact strategies used. of the program on knowledge, attitude and facilitating support on part of the teachers. 15. Family relationships, Marriage related beliefs and expectations and its association with mental health in 17. Neural effects of cognitive remediation in schizophrenia: An New Indian Middle Class: A Transgenerational approach. ERP and fMRI study. Investigators: Dr. Devvarta Kumar, Investigators: Dr. M Manjula, Dr. Pradeep BS, Dr. Dr. BN Gangadhar, Dr. Ganeshan Venkat Subramanian, Dr. Mariamma Philip (Funding by ICSSR) Shivrama Varambally, Dr. Rose D (Funding by DBT)
The study is being carried with the aim of understanding the gamut This study aims to see the neural effects of cognitive retraining (specifically of family relationships, interactions, marital relationships, beliefs home-based training) in patients with schizophrenia. The schizophrenia and attitudes about marriage, the nature of changes in this context patients are being placed in one of the three groups – home-based over the time, across the different age groups. Population based cross remediation group, clinic-based remediation group and the wait-list sectional mixed methods will be adopted for the study. The study control group. Pre- and post-neuropsychological and neurophysiological sample would be drawn from Bengaluru and Kolar, urban, semi urban (fMRI and eeg based ERP) changes will be assessed to determine the and rural areas adopting a representative stratified clustered random effects of remediation. Data collection process is in progress. sampling technique with stratification based on urban and rural families. Approximate sample size would be around 3600. Those in 18. Determining sensitivity and specificity of Event Related the age range of 18-60, who can read write English or Kannada and Potentials for its use as cognitive function biomarker in belonging to middle class economic status will be included. Those Schizophrenia. Investigators: Dr. Devvarta Kumar, Dr. with history of or current diagnosis of mental illnesses (psychosis, Shivrama Varambally (Funding by DBT) bipolar disorder, schizophrenia) and with conditions which comes in the way of interviewing (mental retardation, organic conditions), This study is intended to see the sensitivity and specificity of various people suffering with chronic medical conditions will be excluded. EEG based event-related potentials in schizophrenia. The ERP The study will be carried out in three phases: (i) finalizing the semi- paradigms have been developed and data collection started. structured interview by carrying out brain storming sessions with experts (ii) pilot phase: training of project staff and familiarizing with 19. Collaborative eyewitness memory. Investigators: Dr. Craig data collection and analysis (iii) data collection from urban and rural Thorley (University of Liverpool), Dr. Devvarta Kumar samples of two districts. Though past incidences are usually recalled alone it is not uncommon 16. Mental health literacy on youth depression and suicides to do so in collaboration with others (for example, recalling various for teachers: Impact on knowledge, attitudes, facilitating incidences of school in a get-together of old class mates). The support and help seeking. Investigator: Dr. M Manjula, Dr. present laboratory based experiment aims to examine the impact of Roopesh BN, Dr. B Binukumar (Funding by ICSSR) collaboration on eyewitness recall. Data collection is going on.
National Institute of Mental Health and Neuro Sciences 137 Annual Report 2015-2016
20. Rorschach ‘Comprehensive system’: Preliminary norm for health of pregnant women and their infants, a recently completed Indian adults. Investigators: Dr. Devvarta Kumar, Dr. Manoj pilot study of the US-Indo collaborators have demonstrated K Sharma successful improvement in ART adherence, CD4 levels and physical and mental health among women supported by grant- 21. Professional development of clinical psychology trainee trained HIV Ashas. The investigators will evaluate the effects of therapists. Investigators: Dr. Poornima Bhola, Dr. Ahalya different combinations of Asha support on the health of WLA and Raguram (NIMHANS Intramural Research Grant ) their oldest child (ages 3-8). In addition, the investigators will take advantage of rural India’s excellent mobile phone and computer The study aimed to assess therapist characteristics, positive and technology coverage for both data collection and data transfer. negative aspects of work experience and professional development Following a formative phase, four groups in a 2x2 factorial design among Clinical Psychology trainee therapists in India. This included will be tested and will include Asha support for WLA alone, vs Asha theoretical orientation, sources of learning, therapeutic skill, perceived support plus nutrition training (Asha + Training) vs Asha support progress, therapeutic difficulties ad coping strategies, cultural aspects for WLA plus food supplementation (Asha support + food), vs of psychotherapeutic practice, interpersonal manner, personal both (Asha support + Training + food) to determine the effect of functioning and satisfaction with supervision and the training setting. the Asha-delivered support and nutrition interventions primarily Eighty six trainee therapists from the Department of Clinical on nutritional parameters, ART adherence and mental health Psychology and select M.Phil Clinical Psychology training institutes of the WLA and secondarily on mental health, and psychomotor across the country, completed the assessment at the end of their development. Baseline data on the participants have been collected training. A two-point assessment was completed for a sub-sample of and the study intervention and follow-ups are ongoing. 37 trainee therapists; at mid-point and at the end of training to assess changes in various domains of professional development. 24. Development and evaluation of a brief psychoeducational -interventional training video on depression for Accredited 22. Effectiveness of a mental health intervention in protecting Social Health Activists (ASHA). Investigators: Dr. Aruna oneself against gender based violence and enhancing Rose Mary Kapanee, Dr. KS Meena, Dr. Paulomi Sudhir, Dr. resilience in young adult women. Investigators: Dr. Veena Prasanthi Nattala, Dr. N Manjunatha Satyanarayana, Dr. Chandra PS (Funding by SBR/ICMR) The project aims to develop and evaluate a brief psychoeducational- The aim of the present study is to examine the effectiveness of a interventional training video on depression for Accredited Social peer delivered group mental health intervention in protecting oneself Health Activists (ASHAs). It has a pretest-posttest (one group) quasi- against GBV and enhancing resilience in young adult women from experimental design. The sample will comprise 80 ASHAs (age range: socio economically disadvantaged backgrounds in Bangalore. The 25-45 years) from Bangalore Urban District. They will be administered effectiveness of a peer delivered group mental health intervention semi-structured and structured questionnaires. Based on inputs from on: (a) endorsing equitable gender norms (b) increased perceived focus group discussions with the ASHAs, the video is currently under self-efficacy in protecting oneself against GBV (c) increased development. The video will have inputs to the ASHAs regarding the resilience (d) reduced symptoms of depression, anxiety and stress nature, causes, and impact of depression, followed by interventional (e) increased gender and mental health literacy will be assessed. A components with regard to motivating the individuals to engage in group randomized trial will be conducted using a mixed methods positive health behaviors and problem solving. There will be two post- (qualitative and quantitative) design. Phase I, the formative phase, test measurements after the interventional training. The pilot phase of has been completed. Data through focus group discussion has been the study is ongoing. obtained from 30 participants which are currently being transcribed and translated for analysis. 25. Musical improvisation in jazz and Hindustani musicians: a cross-cultural EEG study (A pilot study). Investigator: Dr. 23. Asha improving health and nutrition of Indian women Shantala Hegde with AIDS and their children. Investigators: Dr. Veena Satyanarayana (Senior Key Personnel: Consultant), Improvisation is a unique form of music-making that has shown Nyamathi Adeline, Mr. Sinha Sanjeev, Ekstrand Maria tangible health benefits. The study of improvisation from a (Funding by NIH R01) neuroscientific perspective has become increasingly popular, from studies of jazz pianists to classical musicians and their audiences, Utilizing the successful model employed by the Indian Government’s freestyle rap artists, and non-musicians. However, the majority of these National Rural Health Mission to address the health needs of the studies (not unlike the rest of music cognition studies) are Western- rural population by training Ashas, village women, to enhance centric; they focus on improvisation purely in the context of the
138 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Western tonal system. Additionally, these results will have an impact and fMRI study. Mr. Mohd Afsar. Guides: Dr. Jamuna on the usage of improvisation to improve health not just within the Rajeswaran, Dr. Dhaval Shukla, Dr. Sarada Subramanian, Western context, but hopefully on a more universal scale. The Emotiv Dr. Rose Dawn Thomas, Dr. B Binukumar system is a research-quality system with fourteen channels and two CMS/DRL references. Four of the channels rest on the forehead. Traumatic brain injury (TBI) is a condition which is rapidly growing The electrodes are dry contact, treated in saline solution to minimize and a great source of concern worldwide. TBI leads to several clinical, impedance. Audio and video data was recorded with a Zoom H4N cognitive, electrophysiological, biochemical and functional alterations. microphone and a Canon Vixia HF S21 HD Camcorder, respectively. Assessment and evaluations of these alterations are vital in planning Consenting Five highly trained professional musicians (vocalists) future neuropsychological rehabilitation. NFT and cognitive retraining were the participants of this study. The findings point towards the both have been used as effective methods of neuropsychological fact that improvisers may back the idea of “flow state,” in that the rehabilitations in TBI. The investigators propose to elucidate improviser does not need to focus, and thus can let their mind wander the underlying mechanism of their actions by clinical, cognitive, as they ‘organically’ produce novel musical sequences with automated electrophysiological, biochemical and functional MRI studies. motor, memory retrieval, and decision processes. Detailed analysis of this data is ongoing. 28. Sexuality and quality of life in women survivors of breast cancer. Ms. Michelle Sangeeta Barthakur. Guides: Dr. 26. Influence of drone induced tonic on emotive response to Mahendra P Sharma, Dr. SK Chaturvedi, Dr. Suraj melody on a diatonic scale (A pilot study). Investigator: Dr. Manjunath Shantala Hegde The objectives of the study is to examine the pattern of body The diatonic scales are those heptatonic scales that can be played on image issues, sexuality, marital satisfaction, anxiety, depression white keys of the keyboard, assuming equal temperament tuning. and overall quality of life in women survivors of breast cancer and They comprise the seven modern western modes. These correspond to examine the relationship between these variables. Quantitative to the seven ‘Shudha Jatis’ in the ancient Indian music theory. In data has been collected from 50 women and qualitative interviews Bhatkhande’s classification of Raagas, six of the 10 Thaats are diatonic with 15 women for those meeting criteria of study. Results reveal scales. The notes used in a diatonic scale occupy seven consecutive depression as predictor of quality of life; qualitative data suggests places in a circle of fifths. Restricting to the white keys without any trends of good coping skills, difficulties encountered with health loss of generality, the a mode can be identified with the tonic that has care system, good social support and post-traumatic growth. Based to be chosen among C,D,E,F,G,A,B. Since each mode is believed on findings of the study contents of an intervention module have to have a distinct emotional perception, it is natural to ask if a piece been offered. of melody conveys different emotion based on the choice of tonic. In homophonic tonal music, the tonic is a property of melody line 29. Efficacy of mindfulness integrated cognitive therapy itself. This study aimed to examine whether a piece of music just by in patients with OCD. Ms. Sonal Mathur. Guides: Dr. qualifying as having a particular tonic automatically has an emotional Mahendra P Sharma, Dr. YC Janardhan Reddy connotation associated with it. A total of 14 half-second tones from two octaves violin in C major scale were taken. In order to realize The aim of the study is to evaluate the efficacy of Mindfulness the circularity of pitches in real sense, they were pairwise combined Integrated Cognitive Therapy (MICT) in the treatment of OCD. to produce a Shepard-scale of seven tones. A sequence of tones is Sixty patients with OCD were randomly allocated to MICT group generated using transition probability matrix. Ten musically untrained or Stress Management Training (SMT) and underwent 12 sessions of participants were made to listen to a 40 second long extract of the therapy. Data was collected on measures of OCD, anxiety, depression, generated melody, seven times with varying drone(viola), randomly quality of life, mindfulness, quality of life and illness severity. between C,D,E,F,G,A,B. They were asked to rate the emotion Preliminary analysis of data shows that MICT has been efficacious perceived between extremely sad (-10) and extremely happy(+10). in treatment of OCD, in comparison to SMT. Participants in MICT They were also asked to verbally describe the closest scenario that is group have significantly higher number of treatment responders evoked, and what in their view would correspond to the two extremes and higher degree of improvement in illness severity compared to of the scale, and asked to choose from given set of adjectives. Detailed participants in SMT group. analysis of this data is ongoing. 30. Effectiveness of acceptance and commitment therapy 27. A randomized controlled trial of cognitive retraining and in patients with somatic symptom disorder. Ms. Fatema EEG neurofeedback training in traumatic brain injury: Khanam. Guides: Dr. Mahendra P Sharma, Dr. SK A clinical, cognitive, electrophysiological, biochemical Chaturvedi
National Institute of Mental Health and Neuro Sciences 139 Annual Report 2015-2016
The aim of the study is to examine the effectiveness of Acceptance setting. The study will explore feasibility, effect in terms of reduction and Commitment Therapy (ACT) on somatic symptoms, anxiety and in symptoms of anxiety and/or depression and improvement in depression, global functioning, psychological well-being and improving overall levels of functioning, in addition to also exploring processes acceptance, mindfulness and valued-living in patients with somatic of group intervention sessions and changes in parents’ knowledge symptom disorder. A two group design with baseline, post and follow- about the nature of the adolescent’s emotional problems. A single- up assessments will be adopted. Forty patients with primary diagnosis group pre-post design will be employed for the study, with three of somatic symptom disorder will be randomly assigned to either ACT points of assessment: pre-intervention, post-intervention and follow- intervention group or treatment-as-usual group and ACT group will up assessment. The study will involve a minimum of five groups of have 8-10 sessions of intervention. Appropriate statistical measures will adolescents aged 12-17 years (in groups of 4-8 boys/girls). Measures be used to assess the improvement and compare the two groups. to assess aspects of feasibility, as well as assessments to assess anxiety, depression and functioning, will be used. The data will be analysed 31. Cognitions, metacognitions, neuropsychological functioning using both qualitative and quantitative methods of analysis. and symptom dimensionality in Obsessive Compulsive Disorder. Ms. Manpreet Kaur. Guides: Dr. Mahendra P This study could point the way towards future clinical services with Sharma, Dr. Keshav Kumar, Dr. YC Janardhan Reddy regard to utilising groups as a means of intervention with adolescents.
Obsessive Compulsive Disorder (OCD) is a heterogeneous 34. Development of a scale to assess experiences in children and condition. Recent research shows one such method used to reduce adolescents. Ms. Snigdhasree Bhattacharyya. Guides: Dr. this heterogeneity is to examine symptom dimensions in OCD. It has Uma Hirisave, Dr. N Janardhana been shown that symptom dimensions have distinct but overlapping brain substrates. There are also some early indications that symptom The aim of the current study is to develop a scale to assess experiences dimensions might have distinct neuropsychological correlates. in children and adolescents. The study would explore how children However, it is unknown that whether symptom dimensions in OCD and adolescents conceptualize experiences in their day to day life and are associated with specific dysfunctional beliefs and metacognitions. various experiences in children and adolescents. Following which a scale Hence, the present study aims to examine obsessive beliefs and will be developed to assess experiences in children and adolescents and metacognitions in OCD symptom dimensions and their relationship psychometric properties of the scale will be established. The sample with neuropsychological functions. will include school going students between 8-16 years of age from English/Kannada medium of instruction. Qualitative and quantitative 32. Development and preliminary evaluation of mindfulness methods will be used for analysis of data. The study will contribute to integrated cognitive behavioural intervention for understanding the construct of experience from the child’s perspective. professional care providers at Cancer Palliative Care Centres. Ms. Amanpreet Kaur. Guides: Dr. Mahendra P Sharma, Dr. 35. Differentiation of self, attachment and marital quality SK Chaturvedi in married persons. Ms. Madhurini Vallikad. Guide: Dr. Anisha Shah The aim of the study is to explore felt needs, professional quality of life and well-being and examine the effects of Mindfulness Integrated The aim of the study was to examine differentiation of self, attachment Cognitive Behavioural Intervention (MICBI) for professional care and marital quality in married persons. Tools used were Beck’s providers at cancer palliative care centres. A mixed-methods cross- Depression Inventory, Marital Quality Scale, Differentiation of Self sectional approach will be adopted in the first phase with a sample of 50 Inventory, and Attachment Style Questionnaire. Analysis of data, from participants. Based on the felt needs obtained from the qualitative data, a clinical sample of 105 married persons, shows that differentiation of contents of MICBI program will be formulated. In the second phase, self is associated with secure attachment and emotional reactivity is a single group study design will be adopted with pre-, post- and three- linked with insecure attachment. In those with marital distress, higher month follow-up assessment with a sub-sample of 25 participants. emotional cut-off is associated with higher avoidant attachment and lower overall marital quality. 33. Outpatient group intervention for adolescents with emotional problems: Feasibility and effect. Ms. Preethi 36. An exploratory study on gender, migration and mental health Anne Ninan. Guides: Dr. Uma Hirisave, Dr. Satish Chandra in persons from the Khasi community. Ms. Ila Lyngksiar Girimaji Rynjah. Guide: Dr. Anisha Shah (Funding by ICMR)
The aim of the study is to explore the feasibility and effect of group The aim of the study was to examine the experience of migration and intervention for adolescents with emotional problems in an outpatient mental health of persons from the Khasi community. A structured
140 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 interview, the Bem’s Sex Role Inventory, the psychological well-being resolution is poorer in couple therapy group whereas identified scale, coping checklist, depression-anxiety stress scales-21, the revised patienthood is problem in family therapy group. This systematically multiphasic questionnaire, a semi-structured interview, as well as a derived knowledge of different types of psychotherapies can help in three-generation cultural genogram were used. Quantitative measures the training of beginning therapists. were used with 148 participants and the interview and genogram were used with a subgroup of 30. Results show that there is gender difference 40. Depression, relationship attributions and automatic in migration experience for persons from the Khasi community, but thoughts in married individuals. Mr. Kiran Kumar CTL. no gender difference on mental health variables. Guides: Dr. Anisha Shah, Dr. Nitin Anand (Funding by NIMHANS) 37. Client experiences in combined couples therapy. Ms. Ashmeet Nagpal. Guides: Dr. Anisha Shah, Dr. Veena AS The aim of the study is to explore depression, relationship attributions (Funding by NIMHANS) and automatic thoughts in married individuals. Participants were married individuals/couples with dysthymia or mild/moderate The study uses a mixed-method design with 40 married individuals depressive episode provided data on MINI Inventory 6, Becks to explore client experiences of helpful and unhelpful aspects, change Depression Inventory, Automatic Thoughts Questionnaire, Marital moments/processes, therapy techniques, goals, themes, therapeutic Attitude Survey and Relationship Attribution Measure. Pilot study on alliance, and satisfaction in individual and conjoint session in five cases helped familiarize the researcher with the study measures and combined couple therapy. Other variables like psychopathology, sample features. Data collection for the main study has been completed marital quality, and differentiation are also examined using the for 40 cases. Analysis of data, interpretation and discussion is in progress. M.I.N.I Neuropsychiatric Interview, the Marital Quality Scale, and the Differentiation of Self Inventory-Revised. Analysis has been 41. Life Adversities, Relational Experiences & Self-Esteem completed using transcription, domain coding, extraction of categories among Women with Alcohol Use Disorders. Ms. Kanika and themes, as well as means and correlation. Interpretation of results Malik. Guides: Dr. LN Suman, Dr. Prabath K Chand, Dr. P and discussion is in progress. Marimuthu
38. Marital therapy for couples with marital distress and sexual The aim of the study is to examine the sociodemographic and clinical dysfunction. Ms. Manjula V. Guides: Dr. Anisha Shah, Dr. profile of women with alcohol use disorders (AUDs). It also aims Manjula M. (Funding by NIMHANS) to explore adverse life experiences, relational factors, self-image and perceived social support among women with alcohol use disorders. The study aims to explore sexual interaction, sexual communication, The study used both quantitative measures and interview techniques marital intimacy and marital quality in 200 married individuals with to collect data. The sample consisted of 35 women with a primary sexual dysfunction and also develop a format for couple therapy. The diagnosis of alcohol use disorder. A sample of 60 women without Sexual Interaction Inventory, the Dyadic Sexual Communication psychoactive substance use drawn from the community was used as Scale, the Marital Intimacy Questionnaire, the Marital Quality Scale, a comparative group. Analysis of data is in progress. The findings and M.I.N.I Neuropsychiatric Interview are being used towards these will contribute to better understanding of the treatment needs of this objectives. Currently, 97 married persons have participated in the clinical population. cross-sectional study and 19 couples have been recruited for couple therapy for whom 97 psychotherapy session have been completed. 42. Feasibility of cognitive behaviour therapy among women with Data collection is in progress. substance use disorders. Ms. Hargun Ahluwalia. Guides: Dr. LN Suman, Dr. Prabath K Chand 39. A study on characteristics of couple and family therapy. Ms. Vasudha KG. Guides: Dr. Anisha Shah, Dr. Mathew The aim of the proposed study is to examine the feasibility of cognitive Varghese (Funding by NIMHANS) behavior therapy among women with substance use disorders. The objectives are to reduce severity of substance dependence, enhance The study objectives were to explore the characteristics of couples in self-esteem and coping self-efficacy and to improve distress tolerance, couple and family therapies. The data included 87 therapy files of 30, emotion regulation and quality of life. The sample will consist of 30 38 and 19 in couple therapy, family therapy and combined couple/ women with a diagnosis of substance use disorder in the age range family therapy respectively. Comparison was made using psychiatric of 18 to 50 years. A CBT framework will be used to plan 12-15 morbidity, presenting problems, therapy structure and the structural sessions of psychotherapy and pre-post assessments will be used to family systems scale. Results showed family therapy group seeks examine the effectiveness of the intervention. Follow-up assessment help for adult personality/behavior issues. Flexibility and conflict one month after completion of the treatment has also been envisaged.
National Institute of Mental Health and Neuro Sciences 141 Annual Report 2015-2016
43. Perceptions of self, recovery and future among men with early 46. Exploration of technology addiction among user with onset substance use disorders. Ms. Tanya Anand. Guides: Dr. psychiatric morbidity. Ms. Aswathy Das. Guide: Mr. Manoj LN Suman, Dr. Arun K Kumar Sharma
The aim of the study was to examine self-stigma, self-regulation, self- Seventy five users with comorbid psychological problems approached for efficacy as well as perceptions of recovery and future among men with assessment of technology addiction using internet addiction test, video early onset substance use disorders. Early onset was defined as onset game addiction questionnaire, pornography addiction screening test and of substance use before 25 years of age. The sample consisted of 40 ADHSD rating scale. Results indicated mobile phone (14/75,18.67%), patients divided into two groups: 20 men with Alcohol Use Disorders internet addiction (21/75(28%), pornography (14/75(18.67%) and and 20 men with Drug Use Disorders. Quantitative measures as well video games (11/75, 14.67%) among subjects with psychiatric problems. as a semi-structured interview schedule were used to collect data. 55.6% (5/9) people, from the group of having total friends 200<400 on Analysis of data is in progress. The findings have implications for Facebook are reported as having an average use of IT and individuals treatment planning. who are having more than 400 friends on Facebook. 2.7% of the sample consulted for management of problems associated with internet use, 44. A randomized controlled trial of cognitive retraining and whereas problematic internet use showed the correlation of 75% with EEG-neurofeedback training in traumatic brain injury: depression; 57% with anxiety, 100% with symptoms of ADHD— A clinical, cognitive, electrophysiological, biochemical indicating implication for screening the technology addiction among and fMRI Study. Mr. Mohd Afsar, Guides: Dr. Jamuna patient seeking treatment for psychological problems. Rajeswaran, Dr. Dhaval Shukla, Dr. Sarada Subramanian, Dr Rose Dawn Bharath, Dr. B Binukumar 47. Efficacy of Metacognitive therapy in patients with social anxiety disorder. Ms. Lakshmi J. Guides: Dr. Paulomi M The present study aims at comparing the effectiveness of CR and Sudhir, Dr. Mahendra P Sharma, Dr. Suresh Bada Math NFT in TBI. It also aims at understanding the underlying processes of these interventions. The study is a randomized controlled trial with The study examined the efficacy of Metacognitive therapy (MCT) three groups i.e. CR, NFT, and Treatment as Usual groups with 30 in patients with social anxiety, comparing it with a control group that patients in each group. Before randomization each participant will received Applied Relaxation on post event processing (PEP) and have to undergo a series of assessments including paper pencil tasks, anxiety. Fifty patients were recruited from the OPD. They received neuropsychological assessment, quantitative EEG, fMRI, serum 10-12 sessions of therapy and were assessed at pre, post and three- cortisol levels and serum tau protein levels. Patients will be given 20 month follow up. Results indicate that MCT and AR were both sessions of allotted intervention and the outcome assessment will be effective in improving PEP, anxiety, depression, while MCT was completed after that. A paper pencil assessment and neuropsychological marginally more effective in improving metacognitions. assessment will be repeated after three months. 48. Process of change in cognitive behaviour therapy (CBT) 45. Schema modes and cognitive distortions in borderline and exposure therapy for social anxiety disorder. Ms. Systla personality disorder: An exploratory study. Ms. Priya Puri. Rukmini. Guides: Dr. Paulomi M Sudhir, Dr. A Shyam Sundar Guides: Dr. Devvarta Kumar, Dr. Thomas Kishore, Dr. Muralidharan K (Funding by UGC JRF) The aim of the study is to examine the role of estimated social cost, perceived social self-efficacy and perceived emotional control as Various studies stress the role of cognitions in psychopathology. mediators in Cognitive Behaviour Therapy (CBT) and Exposure Change in the behaviours of individuals who are resistant to therapy (ET) in patients with Social Anxiety Disorder. change, such as those with personality disorders, can be brought about only by understanding their underlying cognitive processes. Fifty patients with diagnosis of social anxiety will be randomized to Schema modes and cognitive distortions are two such important either CBT or ET. Pilot phase has been completed and main phase has cognitive processes. However, these are not well explored in commenced. Analysis will involve mediational analysis to examine the Borderline Personality Disorder. Since individuals with BPD have changes in mediator variables across sessions of therapy. Weekly assessment dysregulation in a multitude of areas of psychopathology, it can be on mediator variables will be carried out. The main study is in progress. assumed that they may also have a multitude of dysfunctional schema modes and cognitive distortions. Understanding the cognitive 49. Psychosocial correlates of body image perception and processes of BPD shall not only give a better understanding into psychological functioning in young adults. Ms. Athulya their psychopathology, but it shall also be helpful in planning their Jayakumar. Guides: Dr. Paulomi M Sudhir, Dr. Prabha S. treatment better. Chandra
142 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
The study is aimed at examining body image perception and its of Negative Symptoms (SANS), Tool for Recognition of Emotions psychosocial correlates namely perfectionism, teasing experiences, in Neuropsychiatric Disorders (TRENDS), Toronto Alexithymia media and peer influences, interpersonal sensitivity and coping Scale (TAS), abbreviated version of Metacognitive Assessment behaviours, while psychological distress and self-esteem are also Scale, self-reflectivity of Beck’s Cognitive Insight Scale (BCI) and being examined. The sample includes 300 young adults drawn Groningen’s Social Dysfunction Scale (GSDS). Patients with SZ from the community, using a stratified random sampling. The pilot had greater emotion recognition deficits. Emotion recognition, study has been completed along with a try out on 30 community awareness, metacognition were not significantly correlated with participants. The findings have been incorporated and the main each other. Marital status was a significant predictor of social study is in progress. functioning.
50. Psychosocial and Clinical correlates of suicidal behaviour in 53. Emotion regulation therapy in anxiety disorders: an outcome persons with Bipolar Affective disorder, currently euthymic. study. Ms. Vidhya Sagar K. Gudides: Dr. Manjula M, Dr. Ms. Vaisnvy NM. Guides: Dr. Paulomi M Sudhir, Dr. Mahendra P Sharma, Dr. Suresh BM (Funding by ICMR- JRF) Muralidharan K The study aims to examine the efficacy of emotion regulation The study is aimed at examining the clinical and psychosocial therapy in anxiety disorders (GAD, SAD & PD) in improving correlates of suicidal behaviour in patients who are diagnosed emotion regulation and reducing symptoms. In addition, mediating with Bipolar Affective disorder, currently euthymic. The sample role of mindful awareness and homework compliance and role of includes 240 patients with BPAD, screened for their euthymic moderators such as anxiety sensitivity and trait anxiety in outcome status and assessed on various measures such as cognitive felixibility, will be examined. Sample consists of 60 participants (Intervention internalized stigma, and hopelessness. A sub sample of patients who Group, 30 and Treatment as Usual Group, 30). The ERT Group report an attempt will also be interviewed in detail. The pilot study underwent 16 sessions of therapy. Intervention and assessments is nearing completion and will include both paper pencil measures were completed in 22 ERT group and 20 individuals in control and interviews. group. Analysis of the data is completed and the thesis is under preparation. 51. Self-conscious emotions, cognitive emotion regulation and interpersonal sensitivity in emotional disorders. Ms. Preethi 54. Cognitive styles, psychosocial and clinical determinants of A Ninan. Guide: Dr. Paulomi M Sudhir functioning in patients with bipolar disorder. Ms. Mareena Susan Wesley. Guides: Dr. M Manjula, Dr. Jagadisha T Study examined shame, guilt interpersonal sensitivity, cognitive (Funding by UGC-JRF) emotion regulation strategies self-esteem and depression, in 32 patients with emotional disorders and 32 non-clinical participants. The study aimed to examine the cognitive styles, clinical and Participants were assessed on Personal Feelings Questionnaire -2, Test psychosocial determinants of functioning and subjective experiences of Self-Conscious Affect – 3 (TOSCA -3) Interpersonal Sensitivity in patients with bipolar disorder. A sample of 150 patients diagnosed Measure, Cognitive Emotion Regulation Questionnaire, Rosenberg with bipolar disorder, fulfilling the inclusion and exclusion criteria Self-Esteem Scale, Beck Depression Inventory – II. Clinical group were selected for the quantitative study of which a sub-sample of had higher levels of proneness to shame, significantly greater levels 10 were drawn for in-depth interviews. A cross sectional, mixed of interpersonal awareness, separation anxiety, fragile inner self, method exploratory design was used. The study is completed and greater depression and lower self-esteem. They used more self-blame, thesis submitted for evaluation. The findings of the study highlight rumination, catastrophizing, other-blame, less of refocus on planning, the significance of the various clinical, psychosocial and cognitive positive reappraisal, putting into perspective. Guilt, interpersonal variables that affect functioning of patients with bipolar disorder even sensitivity predicted self-esteem. in remission.
52. Emotion recognition, emotion awareness, metacognition 55. Brief cognitive behavior therapy in remitted bipolar disorder. and social functioning in schizophrenia. Ms. Radhika K. Ms. Seema P Nambiar. Guides: Dr. M Manjula, Dr. Shyam Guides: Dr. Paulomi M Sudhir, Dr. Jagadisha Sundar A (Funding by ICMR-JRF)
The study examined emotion recognition, awareness, metacognitive The study is being undertaken to examine the effect of brief CBT processes, social functioning in 27 patients with schizophrenia (SZ), on inter-episodic symptoms, dysfunctional cognitions, adherence to and 26 non-clinical controls. Patients were assessed on Scale for treatment, emotional regulation, functioning and quality of life in Assessment of Positive Symptoms (SAPS), Scale for Assessment remitted bipolar disorder. A two-group randomized control design
National Institute of Mental Health and Neuro Sciences 143 Annual Report 2015-2016 with multiple assessments (pre, post & follow-up at three months) is study and 34 control group individuals. The data analysis and report planned. The sample would consist of 30 patients in the intervention writing is in progress. group and 30 patients in the TAU (treatment as usual) condition in the age-range of 18-55 years. Eight to 10 individual sessions will 59. Adverse childhood experiences, interpersonal functioning be held on a weekly basis for the study group. The pilot study was and emotion regulation in patients with major depression. completed and main study is in progress. Ms. Swathi TP. Guide: Dr. M Manjula
56. Effectiveness of emotional competence skills programme for To explore adverse childhood experiences, interpersonal functioning adolescents. Ms. Lavanya TP. Guides: Dr. M Manjula, Dr and emotion regulation in patients with major depression. The study John Vijay Sagar, Dr. Mariamma Philip used two-group comparison exploratory study design. The sample consisted of two groups; study group comprised of 30 patients The aim of the study is to explore emotional competence and assess with major depression and the control group consisted of 30 never the effectiveness of an emotional competence skills programme for depressed adults matched for age and gender with study group. The adolescents. The sample would consist of 250-300 high school and tools used were Beck’s Depression Inventory II, MINI, Early Trauma pre-university students in the first phase and 200 students in the Inventory –Short Form, Inventory of Interpersonal Problems, and second (study group=100 and control group = 100). The study would Emotion Regulation Questionnaires (DERS and ERQ). The data adopt a prospective design (pre, post and three-month follow up). The collection is completed and analysis of the data and report writing is exploratory phase was completed with 260 samples, the focus group in progress. discussions to finalize the content of intervention, validation of the intervention and pilot testing of the intervention has been completed. 60. Defensive pessimism, perceived stress, coping and The main study is in progress. psychological functioning in youth. Ms. Asha Ravi. Guide: Dr. M Manjula 57. Impact of child sexual abuse on mental health, trauma and attachment beliefs and interpersonal functioning in The aim of the present study was to examine defensive pessimism, young adults. Ms. Radhika K. Guides: Dr. M Manjula, Dr. coping and psychological functioning among youth and examine Jaisoorya, Dr. Binu Kumar (Funding by UGC-JRF) the relationship between the variables. The sample consisted of 200 students. The study was conducted in two phases. Phase 1 aimed at The aim of the study is to understand the impact of child sexual finding out the reliability and validity of defensive pessimism scale and abuse on mental health, trauma and attachment beliefs, interpersonal phase 2 included the main study. The participants were assessed on functioning in young adults. Phase 1 would adopt an exploratory Defensive Pessimism Questionnaire, Cohen’s Perceived Stress Scale, cross sectional design with multistage sampling. The exploratory Proactive Coping Inventory, Rosenberg Self Esteem Scale and Adult phase would involve examining the above said variables on a sample Self Report. The DPQ has significantly high test retest reliability of college students (n=650) in Bangalore and patients attending (0.834). Defensive pessimism had high correlation with perceived psychiatric services in NIMHANS (n=120) of 18-25 years. Phase stress and proactive, preventive, reflective, and strategic coping. 2 would include in-depth interviews with 20 individuals forming community and clinical samples with history of child sexual abuse. 61. Romantic relationships, self-schemas and differentiation The protocol is under review for clearance from the Institute Ethics of self in relation with future time orientation in romantic Committee. relationships of young adults. Ms. Priyanka Mittal. Guide: Dr. M Manjula 58. Early trauma experiences, parental bonding and emotion regulation in borderline personality disorder. Ms. Alafia The aim of the study was to explore experiences of romantic Jeelani. Guides: Dr. M. Manjula relationships, self-schemas and differentiation of self in relation with future time orientation in romantic relationships of young The aim of the study is to explore early trauma experiences, parental adults. With a cross-sectional mixed method exploratory design bonding and emotion regulation in patients with borderline and purposive sampling, the study was conducted in two phases. In personality disorder. Sample would comprise of 30 subjects consisting the first phase, semi-structured interviews were used to prepare a of young adults diagnosed with BPD and 30 subjects consisting of checklist for exploring experiences in romantic relationships. In the young adults who have no psychiatric diagnoses. A cross-sectional second phase, 344 unmarried participants responded to the socio- exploratory research designed will be adopted for the study. The demographic data sheet, the checklist, Young Schema Questionnaire- subjects in the control group were matched for age and gender with S3, Differentiation of Self Inventory- R and Future Time Orientation the study group. The data collection has been completed with 34 in Romantic Relationships. Content analysis, descriptive statistics,
144 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 chi-square, t-tests, ANOVA, correlation coefficients and multiple The study aims to examine individual and relational predictors of regressions were employed for analysis. couple functioning in women with Borderline Personality Disorder and their spouse. The objectives will be to (i) examine individual 62. Experiences of Bullying, body self-esteem and psychological factors such as early trauma, differentiation of self and emotion functioning in young adults. Kangkana Bhuyan. Guide: Dr. regulation in couples where one partner has BPD (ii) examine M Manjula relational factors such as attachment style, intimate partner violence, marital communication, and marital adjustment in couples where The aim of the present study was to explore experiences of bullying, one partner has BPD (iii) compare individual factors such as early body esteem and psychological functioning in young adults. The trauma, differentiation of self and emotion regulation in clinical and sample consisted of 311 students, both males and females. They non-clinical control couples (iv) compare relational factors such as were assessed on Body Esteem Scale, Retrospective Bullying attachment style, intimate partner violence, marital communication, Questionnaire and Adult Self Report. Overall findings suggest that and marital adjustment in clinical and non-clinical control couples, people with bullying experiences tend to have more psychological and (v) explore in-depth subjective experiences of patients with BPD problems compared to people who have no experiences of bullying. and their spouse regarding interpersonal and family functioning, and No statistically significant difference was seen in Body Esteem Scores secondary trauma. The study will use a mixed methods design. A with respect to prior experiences of bullying. On the other hand sample of 40 clinical and non-clinical couples will be recruited. Study people who were in the clinical and borderline level of psychological measures will be individually administered to the patients and their symptoms had lower scores for body esteem. spouses (and to spouses in the non-clinical control group).
63. Mother-child interaction: relationship with wellbeing 67. Dating violence in young adults: An exploratory study. Ms. in mothers with psychiatric illness and child’s cognitive Cassandra Sundaraja. Guide: Dr. Veena Satyanarayana development. Ms. Padmaja Mushahary. Guides: Dr. M Thomas Kishore, Dr. Harish T, Dr. Veena Satyanarayan The current study explored dating violence in the Indian context, and its relationship to attachment styles and mental health. A mixed- 64. Development of a scale to assess the determinants of coping method research design was adopted, integrating both quantitative in parents of individuals with intellectual disability. Ms. and qualitative methods of investigation. Seventy-five undergraduate Vasudha Hande Guides: Dr. M Thomas Kishore, Dr. B and post-graduate students of a Bangalore-based university, who were Binukumar, Dr. K John Viajay Sagar in a heterosexual romantic relationship that had lasted a minimum of three months, participated in the quantitative study (Part I). The 65. Ethical beliefs and practices in psychotherapy and qualitative study (Parts II and III) was carried out concurrently, where counselling: An exploratory study among mental health five women from Part I who either reported no violence on the CTS2 practitioners and development of a training module. Ms. participated in a focus group discussion (Part II), and ten individuals Ananya Sinha. Guides: Dr. Poornima Bhola, Dr. Ahalya who reported dating violence on the CTS2 were interviewed in-depth Raguram, Dr. Prabha S. Chandra (Funding by UGC-SRF) about their experiences (Part III). Results indicated that the rates of dating violence in India are comparable to those reported by Western The study aims to explore the ethical beliefs and practices in literature, with a predominance of bidirectional violence across all psychotherapy and counselling among mental health Practitioners types of violence. Regression analysis implicated childhood emotional and to develop a training module. The first phase includes a survey abuse, younger age, perpetration of bullying, having been away from with a sample of 265 participants including 25 practicing Clinical home during childhood and current substance use as predictors Psychologists, 25 Psychiatrists, 25 Psychiatric Social Workers, 50 accounting for about 41 percent of the variability in the scores of trainees each from Clinical Psychology, Psychiatry trainees and dating violence. Psychiatric Social Work trainees and 40 counsellors. The second phase involves in-depth interviews with 28 selected participants, including 68. Attachment style, mother infant bonding and social support in four from each group. A training module on ethics in psychotherapy women with postpartum onset of common mental disorders. and counseling will be developed based on the findings in the two Ms. Resna Sadan. Guides: Dr. Veena Satyanarayana, Dr. phases. The data collection is ongoing. Thomas Kishore, Dr. Prabha S Chandra.
66. Individual and relational predictors of couple functioning The current study examined the relationship among attachment style, in women with borderline personality disorder and their social support, mother-infant bonding in postpartum women. The spouse. Ms. Fasli Sidheek. Guides: Dr. Veena Satyanarayana, objectives will be to examine the relationship between (i) attachment Dr. Geetha Desai style and mother-infant bonding (ii) attachment style and social
National Institute of Mental Health and Neuro Sciences 145 Annual Report 2015-2016 support (iii) attachment style and mental health and (iv) social support The study aims to explore users’, carers’, mental health trainees’ and and mental health in postpartum women. A single group cross- mental health professionals’ perceptions of recovery from severe sectional design will be used. Adult married women fluent in English mental illness in a rehabilitation centre. The specific objective is to and Tamil, meeting ICD 10 criteria for CMDs will be recruited examine the differences in the perceptions of recovery across the four from outpatient adult psychiatry units and the perinatal clinic. Study groups. The study utilizes a cross sectional design using qualitative measures will be individually administered to women. Relationships method of semi-structured interviews done on a sample of 16; four among the key study variables will be examined using correlational users, four carers, four mental health trainees and four mental health analysis. Data collection for this study is currently ongoing. professionals. Analysis of data is being done by the method of Directed Content Analysis of the interview transcripts of the four groups. 69. Evaluation of facial, musical and prosody emotion recognition in patients with Parkinson’s disease. Ms. Babina 72. A psychosocial exploration of persons seeking divorce. Ms. Asem. Guides: Dr. Shantala Hegde, Dr. Pramod Kumar Pal Suruchi Sonkar. Guides: Dr. Ahalya Raguram, Dr. BM Suresh
The study aimed to study the deficits in facial, prosody and musical Divorce is one of the most stressful life events an individual can emotion recognition and discrimination and to examine the experience. Evidence suggests that marital distress, conflict and correlation between deficits in emotion perception and cognitive disruption are associated with a wide range of deleterious effects functions in patients with Parkinson’s disease (PD). The sample on both adults and children, on physical health and mental health consisted of patients with PD (n=30) and age, education and gender and well-being. The aim of the study is to explore the perceived matched Healthy Controls (32). Participants were subjected to causes of divorce among persons seeking divorce and examine their NIMHANS emotion perception test, musical emotion test and a set mental health and psychological characteristics. These include of neurocognitive tests to measure attention and executive functions. communication, conflict resolution, social support, well-being and Results showed that patients with PD performed poorly in recognizing emotional status. The study is being carried out on persons seeking and discriminating facial as well as prosodic emotion (p<0.01) and in divorce who have been referred for mediation by the family courts. recognizing happy emotion in music (p<0.01). Perception of sadness Data collection has been completed and is being analyzed. in musical domain was observed to correlate with cognitive functions of focused attention, verbal working memory and response inhibition. 73. Integrative systemic therapy for families of youth with mental Facial emotion recognition and discrimination correlated with visual disorders. Ms. Suvarna Joshi. Guides: Dr. Ahalya Raguram, working memory and prosody identification correlated with verbal Dr. Mathew Varghese and visual working memory. The findings of this study are important for future studies aiming to develop intervention programs to target Family therapy attempts to understand human behavior as shaped emotion deficits in PD. by its context. Family functioning has significant implications for the development and well-being of individual members and 70. Development and evaluation of a psychoeducational video includes the individual, marital and the overall family levels for male industrial workers on hazardous use of alcohol. Ms. However, the relative contributions of individual or dyadic factors R Vijayalakshmi. Guides: Dr. Aruna Rose Mary Kapanee, to overall family functioning are not clear and have not been Dr. KS Meena, Dr. Prasanthi Nattala examined in clinical samples. This study aims to examine the impact of systemic family therapy in families of youth with mental The study aims to develop and evaluate a psychoeducational video for disorders on well-being, emotional adjustment, dyadic adjustment male industrial workers on hazardous use of alcohol. The objective and overall family satisfaction and identify predictors of the same. of the study is to examine the impact of the psychoeducational video Data collection is ongoing. on male industrial workers’ level of knowledge regarding hazardous use of alcohol in terms of its causes, effects and management. Sample 74. Effectiveness of an Integrated Intervention Program for would comprise of 50 male industrial workers from a manufacturing Alcoholism (IIPA): To enhance executive functions, affect company in Bangalore. They will be administered the ‘Knowledge regulation, and quality of life. Mr. Rajesh Kumar. Guides: questionnaire on hazardous use of alcohol’. The research will be a Dr. Keshav Kumar J, Dr. Vivek Benegal, Dr. Roopesh BN pretest-posttest (one group) quasi-experimental design. The pilot (Funding by ICMR- JRF) phase of the study is ongoing. The aim of the study was to develop an Integrated Intervention 71. Stakeholders’ perceptions of recovery from severe mental Program for alcoholism (IIPA): IIPA includes 2-3 sessions of illness: perspectives from a rehabilitation centre. Ms. Shini VS. psychoeducation, 18 sessions of cognitive remediation to enhance Guides: Dr. Aruna Rose Mary Kapanee, Dr. Srikala Bharath executive functions and promote executive/cognitive control and
146 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Qigong and Tai-chi Chuan exercise to enhance Self-regulation/affect the estimates of prevalence of different mental health problems in the regulation ability. Qigong and Tai chi chuan also has health benefits. district of Kolar and also regarding feasibility of using a handheld device Behavioral scale, neuropsychological test and electrophysiological for data collection. As of April 2016, data collection was completed for measures were included in this study for baseline and outcome 21000 individuals and seven states had completed data collection. assessment. Follow-up assessment also done. IIPA applied on 25 participants with 25 Treatment as usual group (received routine 2. Analysis of highway crashes and determinants in Kolar treatment, yoga and group therapy on MET and relapse prevention). district. Investigator: Dr. G Gururaj (Funding by Road Results showed IIPA is more effective than routine treatment. Traffic Injury Network (RTIN))
75. Effect of cognitive retraining in stroke patients. Mr. Mohit This project is undertaken with support from Road Traffic Injury Gothwal. Guides: Dr. Keshav Kumar J, Dr. Anupam Gupta Research Network of the World Bank Global Road Safety Facility to identify and analyze the characteristics, patterns and determinants Neuropsychological sequelae of stroke include impairments of road crashes on highways in an Indian district viz. Kolar. During in a wide range of cognitive domains. These deficits include the year, data collection was undertaken from police and hospital attention, concentration, language, memory, executive functions sources in the district to understand the crash patterns and outcomes and behavioral problems in the forms of irritability, disinhibition, on highways traversing through the district. impaired judgment and low motivation. These deficits were found to be debilitating for future social, occupational functioning and 3. Advancing Road Safety in India -2016. Investigators: Dr. employment. Several studies on identifying cognitive deficits in Gururaj G, Dr. Gautham MS (Funding by UL India Pvt. stroke patients have been carried out, but there are very few cognitive Limited) retraining programmes to improve the debilitating cognitive deficits. This study aimed at modifying the existing cognitive retraining The project seeks to develop a national report on the situation of road programme used in TBI pats to suit patients with stroke. The study safety related activities in India with focus on changes since year 2000. used a single case experimental design on five patients. All the Report will be developed by review of available data sources, national patients were assessed on a comprehensive neuropsychological test reports and interaction with stakeholders. The project will throw light battery and WHO quality of life scale (WHOQOL-BREF) before on decadal change in burden of road traffic injuries (RTI), road safety and after cognitive retraining comprising 18 one-hour sessions on interventions, care and response systems to RTIs, surveillance mechanisms a daily basis. The results revealed that patient after undergoing and advocacy endeavours. This report will serve as a useful resource for multi-domain based cognitive retraining demonstrated clinically policymakers, road safety professionals and healthcare providers. significant improvement in terms of neuropsychological functions as well as quality of life. 4. Developing and implementing mental health promotion services for youth in Karnataka – project Yuva Spandana. Epidemiology Investigators: Dr. G Gururaj, Dr. Pradeep BS (Funding by Department of Youth Empowerment and Sports, 1. National Mental Health Survey. Investigators: Dr. Gururaj Government of Karnataka) G, Dr. Girish N Rao, Dr. Pradeep BS ( Kerala, Uttar Pradesh, Gujarat), Dr. Gautham MS (Assam, Manipur), Dr. The project seeks to bridge the gap between youth, their families and Senthil Amudhan (Tamil Nadu, Rajasthan), Dr. Arvind BA the ever changing society and enable a smooth transition of youth ( Jharkand, Chattisgarh, Punjab) (Funding by Ministry of from childhood to adulthood. The aim is to develop and implement an Health and Family Welfare, Govt. of India) integrated behavioural, mental and psychosocial support service for the youth through the district youth empowerment centres in Karnataka. Mental, neurological and substance use disorders (MNS) are increasing Key activities of the project Yuva Spandana include: (i) developing a in India. The number of Indians affected with MNS disorders is not certified training module in behavioural, mental, physical, emotional, clearly known and the available estimates are based on data that is more environmental, educational, personality, family and relational issues of than two decades old. The national survey proposes to estimate true youth and their parents throughout the state of Karnataka (ii) training burden of mental health problems in a representative population and 150 potential Yuva Parivarthakas and about 750 Yuva Mithras as support provide a framework for evaluating the impact of DMHP. The objectives service providers and establishing guidance centres (Yuva Spandana of the pilot study in Kolar district are to understand the feasibility of Kendras) to provide these supports services in 10 districts of Karnataka. the sampling design adopted for the National Mental Health Survey, and identify challenges and operational feasibility of the proposed study 5. Developing and implementing life skills and counselling methodology including use of MINI instrument. It would provide services for youth through NSS co-ordinators in Karnataka.
National Institute of Mental Health and Neuro Sciences 147 Annual Report 2015-2016
Investigators. Dr Pradeep B S, Dr G Gururaj (NSS networks and advocacy. The study also highlights the need to Wing, Department of Youth Empowerment and Sports, extend the anti-stigma interventions to community through Government of Karnataka) information, dissemination and media advocacy to reduce stigma, to improve mental health care service utilization and promote 6. Health and work productivity: A retrospective record analysis positive mechanisms for better recovery. in TKMPL limited. Investigators: Dr. Gautham MS, Dr. Pradeep BS, Dr. Kowshik Kupatira, Dr. Gururaj G (Funding 9. Development of questionnaire to assess the Barriers by Toyota Kirloskar Motor Private Limited) for Childhood Disability Care (BCDC) for the service providers. (Supported by Indian Academy of Cerebral Palsy). The aim of the project was to assess relationship between health Investigators: Dr. Senthil Amudhan, Dr. G Shashikala, status and productivity among workers in TKML, Bidadi. The study President, Indian Academy of Cerebral Palsy, Dr. Meenakshi analysed serial data pertaining to 6102 employees from different Girish, Associate Professor, NKP Salve Institute of Medical sources like annual medical examination, clinic visits, health insurance Sciences and Research Centre, Nagpur, Dr. Maria Lewin, claims, sickness absence and cars produced, during the period 2010- Associate Professor, Department of Pediatrics, St. John’s 2014. Respiratory symptoms formed the predominant reason for Medical College, Bangalore. clinic visit while enteric fever was the major reason for insurance claims among the employees. Overweight and elevated BP is on the Early diagnosis with a multidisciplinary approach is the key for rise since 2010. There is much scope for health promotion regarding effective management of childhood developmental disorders. NCDs and mental health as it is expected to impact productivity in However, the condition poses considerable diagnostic and TKML. therapeutic challenges not only to the individuals and their families but also to health care providers. A study instrument “Barriers 7. Health promotion in workplaces - A scoping study. for Childhood Disability Care (BCDC) - Provider Version” was Investigators: Dr. Gautham MS, Dr. Gururaj G (Funding by developed by the inter-disciplinary research team though desk WHO-INDIA) review, focused discussions, and expert inputs to assess the physician barriers in providing early childhood disability care. The self- The present scoping study is being initiated to develop a report to administered questionnaire had six parts, focusing on Clinico-Social document ongoing healthy workplace initiatives for health promotion Details, Screening Barriers, Management Barriers, Referral Issues, in the organized and unorganized labour sectors in India. Review of Early Intervention for Childhood Disabilities, Needs and Support literature and key informant interviews will be conducted to prepare Issues of physicians in providing early childhood disability care. the report. The project will help in the process of understanding health promotion models in various workplace settings and provide 10. Barriers for Childhood Disability Care (BCDC) - A clues for integrating mental health into the same. multi-centric pilot survey. (Supported by Indian Academy of Cerebral Palsy). Investigators: Dr. G Shashikala, 8. Stigma experience and related barriers of help-seeking in President, Indian Academy of Cerebral Palsy, Dr. Senthil psychosis, depressive disorders and alcohol use disorders: A Amudhan, Dr. R Premlatha, Professor and Head, hospital based exploratory study. Investigators: Dr. Senthil Department of Pediatrics, Bangalore Medical College Amudhan R, Dr. Girish N, Dr. Santosh Loganathan, Dr. and Research Institute, Dr. Meenakshi Girish, Associate Arun K (Funding by NIMHANS) Professor, N.K.P. Salve Institute of Medical Sciences and Research Centre, Nagpur, Dr. Maria Lewin, Associate The study found that patients with alcohol dependence and Professor, Department of Pediatrics, St. John’s Medical caregivers also experience significant stigma which were College, Bangalore, Dr. Gayatri Devi, Assistant Professor, comparable and sometimes even higher than psychosis and Department of Pediatrics, Bangalore Medical College and depression. Thus anti-stigma interventions must be considered Research Institute for patients with alcohol dependence and caregivers to overcome stigma related barriers to treatment seeking, and to enhance A pilot survey was undertaken by researchers from Indian their acceptance in the community. Overall, the study highlights Academy of Cerebral palsy (IACP) and NIMHANS, Bengaluru that stigma and related barriers to treatment seeking should be to assess the acceptability and feasibility of administering “Barriers reduced not only by increasing the accessibility, affordability for Childhood Disability Care (BCDC) - Provider Version” and to and availability of mental healthcare services, but also urges the provide insights into the physician barriers to childhood disability health systems to focus on the integrated model with multifaceted care for developing early diagnosis guidelines for childhood approach involving education, strengthening of support system developmental disability in India.
148 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
The study was conducted among the physicians treating children 2003 were undertaken to assess awareness about the act. Majority of in three cities in India Nagpur (Maharashtra), Bangalore and Kolar the Public Places (91.41%), Educational Institutions (74.43%), Mass districts (Karnataka). The study identified lack of confidence and Media Entertainment Sites (75.46%) and Point of Sales (95%) were non-availability of convenient screening tool as the greatest challenge shown to have partial compliance with their respective sections of the in diagnosing the childhood disabilities in their clinical practice. This act. No or complete compliance with the sections were very minimal. pilot survey has thrown light on the major barriers and needs of early This shows that efforts to achieve complete compliance among all childhood disability care and has provided necessary evidence to carry those with partial compliance will go a long way in achieving the out the main study. objectives of the COTPA 2003.
11. Barriers for Childhood Disability Care in the community. 14. Assessment of mental health stigma among health assistants Investigators: Dr. Girish N, Dr. Senthil Amudhan R in Kolar District, Karnataka. Dr. Ramesh Babu E. Guide: Dr. Senthil Amudhan R (Funding by CPH) A survey was undertaken in Kolar town, Karnataka to assess the various barriers involved in providing childhood disability care in the A cross-sectional survey was undertaken among 291 health assistants community. The survey was carried out among 17 disabled children in Kolar District to assess the stigma related knowledge, attitudes and (identified through government reports and key informants) using behavior. The study reported a higher knowledge but less favourable embedded multiple case design. Each embedded units (consisting of a behaviour and attitude. This finding highlights that policies or disabled child, their parents, ASHAs, School teachers and Anganwadi programmes should aim at attitude enhancing anti-stigma campaigns workers) were interviewed using separate semi-structured interview that will include a universal approach and structured training course schedule. The study identified key gaps and barriers in providing and for health care providers with focus on social contact and mental accessing disability care in the community. health care. This will not only improve the attitude and behaviour of health care providers towards people with mental illness but also 12. Performance assessment of Yuva Spandana Project in reduce the treatment gap. Karnataka. Dr. Chandan Kumar S. Guides: Dr. Gautham MS, Dr. Pradeep BS (Funding by Funded by Youth Empowerment and Sports Department, Government of Karnataka) Human Genetics
This is a cross-sectional study conducted to assess the performance 1. Effect of small molecules on the survival of human brain of Yuva Spandana Project in 10 districts of Karnataka, enumerate all and nervous system tumor cells in vitro. Investigator: Dr. project sites (Yuva Spandana Kendras), project staff (4), stakeholders Rajalakshmi Gope (38 Yuva Parivarthakas, 10 DYES officers), 10% of the beneficiaries and 10% of the referral institutions by adopting a mixed methodology The study is aimed at exploring the effect of small molecules on approach. A Logical Framework Analysis and tool kit (Sections the modulation of the level and post-translational modification(s) A,B,C) containing study instruments for assessing the performance of RB1 and p53 gene products in human intracranial tumors in of each stated project activity was prepared. Overall, Yuva Spandana vitro. The human intracranial tumor samples were exposed to small Project is progressing in the right direction but needs improvement molecules and their effects were analysed on tumor cell survival/ cell in the areas of record maintenance, service utilisation and training of death in vitro. The data indicates that the small molecules modulate Yuva Mithras. the post-translational modifications such as phosphorylation of pRb and p53 proteins. The small molecules also affect the expressions 13. Compliance to Cigarettes and Other Tobacco Products of other cell survival/cell death genes in the treated samples as Act (COTPA) 2003 Section 4,5,6 and 7 in Kolar District. compared to the untreated ones. The data shows that the small Investigators: Dr. Mahamood Shariff. Guide: Dr. Pradeep molecules mediate cell death pathway in the brain tumor cells in a BS (Funding by CPH) p53 dependent or p53 independent manner based on the brain tumor type. The results could lead to development of small molecules such A study was undertaken to evaluate the compliance with COTPA as sodium butyrate as possible therapeutics to manage the human sections 4, 5, 6 and 7 in 489 randomly selected public places, 489 brain and nervous system tumors. retail stores, 284 educational institutions, 18 theatres and 226 households with televisions in Kolar district. In addition, interviews 2. Effect of growth factors and small molecules on wound with the Persons Responsible for Compliance (PRC) with the act and healing in diabetic animal model. Investigator : Dr. Authorized Officers (AO) responsible for enforcement of COTPA Rajalakshmi Gope
National Institute of Mental Health and Neuro Sciences 149 Annual Report 2015-2016
The study is aimed at understanding the effects of growth factors 5. Understanding the Th17 cytokine-mediated pathogenesis in cutaneous wound healing process in diabetic mouse model. of Guillain Barré Syndrome: An integrative biochemical, Various growth factors plus a variety of small molecules alone or in genetic and gene expression study. Investigators: Dr. Monojit combinations were tested for their possible beneficial effects, if any, Debnath, Dr. Madhu Nagappa, Dr. Arun B Taly (Funding by on the quality and rate of wound healing process. Application of DST-SERB, New Delhi) growth factors PDGF-BB and EGF along with sodium butyrate in a sequential, time-bound manner enhanced the diabetic wound Guillain Barré Syndrome (GBS) is an immune mediated acute healing in mice model. The growth factors plus sodium butyrate inflammatory disorder in the peripheral nervous system. The roles of also modulated the gene expression patterns in the treated wounds activating, antagonizing and effector cytokines of Th17 pathway are as compared to the untreated controls. The data also shows that being examined in an integrative approach in GBS. In addition, genetic this combination also improved the quality of the healed wound. variation of the genes related to Th17-signaling is being studied to The combination of growth factors plus sodium butyrate could be understand whether such genes play any role in determining genetic developed into therapeutic option to manage human diabetic wound. predisposition to GBS. Functional genetic polymorphisms within IL-17, IL-10 and IL-27 genes have been investigated in 125 GBS 3. Effect of aluminium chloride on the p53 gene expression in patients and 75 healthy controls. The findings of this study suggest mouse brain. Investigator: Dr. Rajalakshmi Gope the influence of genetic determinants of Th17 pathway on GBS progression and severity. IL-10 genotype was found to be significantly The study is aimed at understanding the effects of aluminum chloride associated with MRC score and the presence of antecedent event in on the p53 gene expression in mice model. Aluminum has been GBS patients. previously shown to affect expression of genes involved in neuronal function and signaling. The p53 gene is one of the important genes Genotyping of three polymorphic variants: IL-10 (rs1800872), IL- with multiple functions such as cell cycle, cell differentiation, apoptosis, 17 (rs2273915) and IL-27 (rs153109) was done by PCR-RFLP aging, etc. The data from this study shows that oral administration of in 125 GBS patients and 75 healthy subjects, recruited during aluminum chloride affects the cell survival/cell death pathway in the 2014-2016. IL-27 genotype was observed to be associated with brain cells in mice model. These data could help in understanding inexcitable pattern and abnormal Creatinine Kinase levels in GBS similar aluminum chloride induced patho-physiological conditions in patients. GBS patients carrying GG genotype of IL-17 was found human. to require ventilation.
4. Expression and regulation of p16 and Bmi1 genes in Human 6. The Immuno-Psychiatry in South India Study (IPS)- Glioma Progression. Investigators: Dr. Chetan GK, Dr. Immunogenetic and Immuno-phenotype Characterization Dhananjaya I Bhat (Funding by SERB, DST, India) of Major Psychoses. Investigators: Prof. Vir Singh Negi, JIPMER, Prof. MA Vijayalakshmi, VIT, Dr. Monojit Glioma is a broad category of brain tumors that come from glial cells, Debnath (Funding by Indo-French Centre for the Promotion are the most common primary malignant neoplasms of the central of Advanced Research) nervous system. So many mutations occur frequently in genes that control cell cycle and proliferation leading to tumor progression. Comparison of immune dysregulation in schizophrenia and bipolar The understanding of the role of bmi1 and p16 tumor suppressor disorder in two geographically distinct population groups (French gene in diagnosis of glioma, especially at the transcriptional level is Caucasians and South Indians) encountering distinct environmental in infant stage. Gene alteration studies of both genes will be helpful factors are being examined in this study. This will provide insights for the diagnostic and therapeutic purposes. Main alterations in p16 into the genetic and biological heterogeneity of these disorders within gene include mutations and transcriptional regulations and deletions and across the studied population-groups, immunogenetic basis of in one of the exons. Aberrant methylation of p16 in gene in serum associated auto-immunity, and environmental influences on human can be an early diagnostic tool in glioma. Analysis of p16 SNPs in Human Endogenous Retroviruses-W family in establishing the Indian population may help to develop personalized medicine. Bmi1 disease and in relapsing the episodes. gene amplification and transcriptional and post transcriptional modification will be useful in prognosis of glioma. In this project, 7. Understanding the prenatal infection induced the investigators are considering the correlation of alterations in immune mediated risk of schizophrenia in a rat model. both genes with the clinical data. So these genes can be considered Investigators: Ms. Pinku Mani Talukdar, Dr. Monojit as good prognostic and diagnostic markers in glioma especially in Debnath (Funding by DST, New Delhi under WOS-A the Indian population. scheme)
150 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Schizophrenia is a complex and debilitating neuropsychiatric were found to be associated with early age at onset and CGI severity disorder whose etiology is yet to be ascertained. Multiple in patients with schizophrenia. epidemiological and translational studies over the last few years have suggested a significant role of neurodevelopmental abnormality in the risk and progression of schizophrenia. Although a number of environmental factors are known to impair crucial phases of early brain development, maternal infection has been established to be a significant risk factor in the neurodevelopmental origin of schizophrenia. Emerging evidence suggests that maternal infection enhances the risk of the schizophrenia-like behavior in the offspring not by directly affecting fetal brain but through maternal immune activation/inflammatory responses. However, the precise mechanism of maternal infection induced immune-mediated risk of schizophrenia is poorly understood.
To understand the risk and mechanisms of schizophrenia-like behavioral changes in the offspring of mothers exposed to prenatal infection, the investigators propose to study how prenatal infection 1A: Impact of sHLA-G levels on age at onset of Schizophrenia. elicits Maternal Immune Activation (MIA) and subsequently alters feto-maternal immune balance and leads to fetal neuroinflammation in a rat model.
8. Study on the influence of O-6-methylguanine-DNA methyltransferase (MGMT) gene on downstream DNA mismatch repair genes in Human high grade malignant Glioma. Mr. Jeru Manoj. Guides: Dr. Chetan GK, Dr. Narasinga Rao (Funding by UGC- Maulana Azad National Foundation, UGC, India)
9. Study on the regulation of human telomerase in glioblastoma cell lines using knockdown approaches. Ms. Lavanya Ch, Guides: Dr. Chetan GK, Dr. Srinivas Bharath MM (Funding by UGC-Rajiv Gandhi National Fellowship, India) 1B: Impact of sHLA-G levels on CGI severity of Schizophrenia patients.
10. Evaluation of immuno-inflammatory pathways of 11. Immunogenetic investigations of Interleukin-6 (IL-6) schizophrenia: Study of potential interactions between abnormalities in Schizophrenia. Ms. Deepthi Venugopal. HLA-G, NRG-1 and cytokines. Ms. R Ashwini. Guides: Dr. Guides: Dr. Monojit Debnath, Dr. Venkatasubramanian Monojit Debnath, Dr. G Venkatasubramanian (Funding by Ganesan, Dr. Moinak Banerjee (RGCB, Trivandrum) NIMHANS intra-mural grant and DST-INSPIRE) (Funding by UGC)
Immunopathogenesis of schizophrenia has become a predominant A spectrum of immunological abnormalities has been implicated research paradigm in recent times. The investigators examined the in schizophrenia. Interleukin-6 (IL-6), a pleiotropic cytokine, is an functional role of HLA-G molecules that play a vital role during important candidate locus in neuropsychiatric disorders because of its early neurodevelopment and pro- and anti-inflammatory cytokines in significant role not only in immuno-inflammatory pathways but also schizophrenia. In addition, influence of feto-maternal compatibility at in neurodevelopment and central nervous system functions. In this the HLA-G locus in schizophrenia was analyzed. Functional variants study, the influence of genetic, gene expression and epigenetic changes of HLA-G confer significant risk to schizophrenia and are also of IL-6 gene on the risk and progression of schizophrenia are being associated with psychopathological features like third person auditory examined. In addition, the status of anti-alpha7 nicotinic acetylcholine hallucinations and first-rank symptoms. Further, levels of sHLA-G receptor (alpha7nAChR) antibody and the interaction between IL-6
National Institute of Mental Health and Neuro Sciences 151 Annual Report 2015-2016 mediated inflammatory and cholinergic anti-inflammatory pathway desirable change in the knowledge, attitude and practice domains are being investigated in schizophrenia patients. among children.
12. The role of Th17-mediated Immuno-Inflammatory pathway in Schizophrenia. Ms. Manjula S. Guides: Dr. Monojit Debnath, Dr. Shivarama Varambally (Funding by UGC- RGNF)
Schizophrenia is a heterogeneous neuropsychiatric disorder with an unknown etiopathology. Studies have linked schizophrenia to chronic low grade inflammation. Emerging research suggests newly identified Th17 cells as the crucial mediators of inflammation. This is achieved by producing an array of inflammatory cytokines (e.g., IL-17, IL-21, IL-22). Responses to the regulation of Th17 are dependent on various differentiation (TGF-β, IL-6), growth and stabilization (IL-23) and transcription (STAT3, RORγt) factors. In this study, an integrated biochemical, genetic and gene expression approach will be adopted to delineate the roles of the activators, attenuators and effectors cytokines of Th17 pathway in schizophrenia.
Mental Health Education
1. Outcome of a school based health education program for DVD on First Aid for Children during a seizure epilepsy awareness among teachers and school children. Investigators: Dr. KS Meena, Dr. Prakashi Rajaram, Dr. P Marimuthu, Mr. Kanappa Setty (Funding by NIMHANS)
A diagnosis of epilepsy has a major effect on children; especially among school children. Studies have shown that a significant proportion of teachers and students have negative attitude and misunderstanding of epilepsy making it difficult for a Child with epilepsy. At the same time, there is dearth of literature regarding interventions to bring about a change in the attitudes of children. The aim of the present study was to study the outcome of a school based health education program for epilepsy awareness among school children. The objectives were to assess the level of knowledge, attitude, and practices about epilepsy and relationship among these variables. A total of 70 children, from 8th-10th standard were selected randomly for the study. For the study purpose knowledge, attitude, and practices of epilepsy instrument was developed and face validated by experts.
Results show that the mean, median, mode age of the respondents in the study was found to be 14.55 (±1.33), 15 and 14 years respectively. The gender distribution of the respondents shows that 54.9% are boys and 45.1% are girls. With regards to knowledge, attitude and practices Epilepsy a guide for teachers in English in epilepsy, Correlation shows that knowledge is having strong positive correlation with attitude (p=0.001, r=.423) and practice domains 2. Development and evaluation of a brief health education (p=0.001, r=.486). Post attitude and practice have positive correlation training video on cerebral venous thrombosis for Accredited (p=0.001, r=.338), which shows that positive attitude brings positive Social Health Activists (ASHA). Investigators: Dr. Meena practice. Hence, it is concluded that the training program brings KS, Dr. Girish Kulkarni, Dr. Priya Treesa Thomas
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Developing interventional video and resource materials for educating 3. A multicenter, prospective, observational registry for the community health workers with regard to preventing cerebral assessment of clinical outcomes in Indian adult (≥18-40 years, venous thrombosis among postpartum mothers is the need of the ≥41-65 and >65 years) in patients undergoing surgery ≥2 hour. The present study, being the first of its kind in India, attempts to hours duration during Suprane ® Anaesthesia. Investigators: fill this need by developing a brief educational-interventional training Dr. VJ Ramesh, Dr. M Radhakrishnan (Funding by Baxter video for stroke affecting postpartum woman. The advantages of (India) Ltd.) training by using a video method are: (a) it facilitates audio-visual learning (ii) a standard format can be retained for training across It is a multi-institutional study. The primary objective is to obtain various regions with dubbing of the video into local languages as information on practice and usage patterns of Desflurane when required, and can be easily disseminated. administered in a real-world setting to adult inpatients in India. Secondary objectives are to evaluate the length of time for recovery Tool to assess the knowledge of cerebral venous thrombosis among from anesthesia and the quality of recovery from anesthesia with the ASHA workers is being formulated by the investigators usage of desflurane. Data has to be collected and uploaded online. After pooling data from all the centres, analysis will be carried out with respect to various recovery parameters. Neuroanaesthesia 4. Non-invasive bedside optic nerve sheath diameter assessment 1. Heart rate variability as a tool to assess autonomic using ocular ultrasonography in neurological/neurosurgical nervous system in patients with neurosurgical disorders. patients. Investigators: Dr. Sriganesh K, Dr. Gopalakrishna Investigators: Dr. M Radhakrishnan, Dr. VJ Ramesh, Dr. KN, Dr. Sudhir V Nupur Pruthi (Funding by DST) 5. Non-invasive assessment of cardiac function and cerebral The higher centres of control of autonomic nervous system (ANS) oxygenation in patients with neurovascular diseases. lie within the brain. Lesions involving the brain structures have Investigators: Dr. Sriganesh K, Dr. Sudhir V (Funding by the potential to alter the functioning of ANS which controls ISNACC) cardiovascular and respiratory systems. In this observational study, heart rate variability (HRV) was used to assess ANS before and after 6. Upper airway morphology and hemodynamic changes during the neurosurgical procedure to see the pattern of ANS involvement. sedation with dexmedetomidine and propofol for neuro- Also, its influence on the intraoperative hemodynamic changes was diagnostic procedures. Investigators: Dr. Sriganesh K, Dr. recorded. The study was designed to include 300 patients from five Jitender Saini types of neurosurgical disorders. Data collection has been completed and analysis is in progress. 7. Intraoperative cardiac output monitoring and its impact on neurological outcome in patients undergoing emergency 2. Production and biocompatibility testing of indigenous craniotomy for Traumatic brain injury. Investigator: Dr. Intracranial Pressure Sensor (ICP Sensor) and monitor. Sudhir Venkataramaiah (Funding by NIMHANS) Investigators: Dr. VJ Ramesh, Dr. GS Umamaheswara Rao. (Funding by Society for Biomedical Technology (SBMT). 8. Comparision of propofol and midazolam in refractory status epilepticus. Dr. Dheeraj Masapu. Guides: Dr. GS The intracranial pressure increases in several neurological and Umamaheswara Rao, Dr. Sanjibsinha, Dr. Gopalakrishna KN neurosurgical conditions, most serious among them being severe traumatic brain injury. Monitoring this pressure and prompt treatment Refractory status epilepticus (RSE) is defined as SE that fails to respond improves the outcome in subjects with head injury. Routinely, it is not to first- and any two drugs in the second-line therapy. Twenty three being done due to high cost. A reliable and cheaper ICP monitoring patients of diagnosed RSE were recruited prospectively and randomized sensor can be made in India. This will enable more number of patients to receive either propofol or midazolam infusion for seizure control, in whom the ICP can be monitored and thus improving the outcomes under EEG monitoring according to standardized protocol. of severe brain injured patients. The technology was developed in the earlier project with Indian Institute of Science (sponsored by There was significant difference between the groups in terms of the SBMT), which involves manufacturing sensors and testing their duration of mechanical ventilation [Propofol vs Midaolam: Median biocompatibility. A company by name SITAR is packaging and (interquartile range) 9 (4.5-12.5) vs 15 (14-23) days, p=0.006], manufacturing the sensors. At present, they are in the advanced stage duration of ICU stay [11 (6-13.5) vs 15 (14.25-23) days, p=0.006] of production. and duration of hospital stay [11 (7-13.5) vs 22 (15.75-43.25) days,
National Institute of Mental Health and Neuro Sciences 153 Annual Report 2015-2016 p=0.006]. Termination of infusions due to successful seizure control arterial pressures, heart rates and total peripheral resistance did not show any significant difference (p=0.609). decreased significantly from baseline to post prone positioning in the study group. Cardiac output and cardiac index, stroke volume Despite the limitation of small sample size, outcomes seem to be and stroke volume variation remained stable through induction better with propofol infusion rather than midazolam. Future studies and prone positioning. Hypotension can occur commonly during with larger sample sizes are likely to validate this finding prone position surgeries in cervical myelopathy patients as seen in our study and this can compromise spinal cord perfusion in these 9. A comparative study of postoperative pain following general patients. From the findings, it can be concluded that it is better to anaesthesia with isoflurane and sevoflurane in spine surgery. treat this hypotension with vasopressors rather than inotropes. Dr. Vivek Rayadurg. Guides: Prof. Bhadrinarayan V, Dr. Sudhir V 11. Evaluation of dexmedetomidine as an anaesthetic adjunct to propofol during bispectral index guided anaesthesia Volatile anaesthetics have a biphasic effect on pain sensitivity in for cerebello-pontine angle surgeries. Dr. Dhritiman animal models. Several volatile anaesthetics increase sensitivity to pain Chakrabarti. Guides: Dr. KR Madhusudan Reddy, Dr. at low concentrations but relieve pain at higher concentrations. This Sriganesh K prospective, observational study involving 100 patients was designed to identify whether the volatile anaesthetic agents commonly used Cerebello-pontine angle (CPA) surgeries tend to carry the surgeon’s (isoflurane and sevoflurane) had any bearing on the severity of knife uncomfortably close to the brainstem, putting various cranial acute postoperative pain. We found that patients anaesthetised nerves at risk for damage. Total Intravenous Anaesthesia technique with isoflurane have significantly less pain and are pain-free earlier with propofol is considered as the anesthetic technique of choice for as compared to those anaesthetised with sevoflurane (p<0.05). Also, such surgeries. High dose propofol can result in undesirable effects lumbar spine surgical procedures are significantly more painful than like delayed awakening and metabolic acidosis with increased lactate surgical procedures of cervical and dorsal spine (p<0.05). levels. Dexmedetomidine has been used as an anaesthetic adjunct to propofol and has been shown to reduce propofol requirements. 10. Cardiac output and other hemodynamic changes with prone The aim of this study is to compare the anaesthetic technique of position in cervical myelopathy patients undergoing surgery. dexmedetomidine as an adjunct to propofol with propofol alone Dr. Nitin M. Guides: Dr. VJ Ramesh, Dr. M Radhakrishnan during Bispectral Index guided anaesthesia for CPA surgeries using cranial nerve monitoring. Prone position under anaesthesia significantly alters cardiovascular physiology. Cervical myelopathy patients are known to have 12. Observational study of body temperature changes in autonomic dysfunction and when positioned in prone position under patients undergoing interventional procedures in the anaesthesia, they carry a higher risk of developing hemodynamic neuroradiological suite. Dr. Uttarwar Akshay Jayant. Guides: changes and this can compromise spinal cord perfusion. This Dr. V Bhadrinarayan, Dr. KN Gopalakrishna prospective observational study was conducted on 15 patients with cervical myelopathy who underwent surgery in prone position at our Exposure to low ambient temperature in neuroradiological suite (20- hospital .The non-invasive cardiac output monitor (NICOM) of 22°C) in patients undergoing intervention under general anesthesia cheetah medicals was used to record the hemodynamic parameters. makes them susceptible to inadvertent spontaneous hypothermia; use After taking baseline readings in the pre-op holding area, patients of air warmer is not possible. Temperature change in them and their were induced with inj. fentanyl 2mcg/kg i.v + inj. Thiopentone recovery characteristics will be observed by the investigators. Patients 3-5mg/kg i.v + inj vecuronium 0.1mg/kg i.v and the patient aged 18-60 years, undergoing elective endovascular procedure under was ventilated with 100 % oxygen. After two minutes of induction, general anaesthesia for more than two hours are included. a post induction reading of all hemodynamic parameters was recorded. Xylocard 1mg/kg i.v was given and after one minute, the Pre-induction axillary temperature will be measured. Every 15 min patients were intubated. After two minutes of intubation, a post axillary and nasopharyngeal temperature will be measured till the end intubation reading of all the hemodynamic parameters was recorded. of intervention. Postoperatively emergence and extubation time with After intubation, anaesthesia was maintained with O2+air(50:50) Aldrete score at 5 and 10 minutes will be noted. and 1 MAC Sevoflurane with hourly supplementation of 1mcg/ kg fentanylthereafter hemodynamic parameters were recorded 13. Evaluation of analgesia nociception index monitor in before prone positioning and there after every 5 min, till 20 min. managing Intraoperative pain during neurosurgery. Dr. In this study, investigators found that hypotension was common Kaushik A. Guides: Dr. Madhusudhan Reddy, Dr. Sriganesh with anaesthesia induction and after prone positioning. Mean Kamath
154 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Analgesia Nociceptive Index monitor (ANI) (Metrodoloris, France) 16. Effect of anaesthetics on Glioblastoma cell line migration, based on parasympathetic component of heart rate variability may proliferation and matrix metalloproteinase-2. Dr. provide objective information about the degree of pain noninvasively. Mohit Mittal. Guides: Dr. Umamaheswara Rao GS, Dr. In this study, the investigators will compare requirements of fentanyl Nandakumar DN during elective neurosurgery in patients who receive scalp block using local anaesthetic with those who receive scalp block using Tumour metastasis is a complex process that includes cellular normal saline aided by ANI monitoring. All patients under American separation from the primary tumour, migration through surrounding Society of Anaesthesiologists (ASA) class I and II undergoing tissues, invasion of the intravascular space, cellular transport in the elective craniotomy (supratentorial or infratentorial surgery) and bloodstream, and subsequent extravasation and proliferation in the spine procedures will be eligible for inclusion in this study during an target tissue or organ. Anaesthetics are widely used during brain 18-month study period. surgery. Anaesthetics and anaesthesia techniques have some impact on invasion and migration ability of tumor cells that can possibly 14. Incidence and impact of cardiac dysfunction in isolated affect long-term outcome of patients who have undergone cancer traumatic brain injury patients requiring surgical surgery. This study was planned to investigate the effect of inhalation intervention. Dr. Bharath S. Guides: Dr. G Umamaheshwara and intravenous anaesthetics on cell proliferation and migration of Rao, Dr. Radhakrishnan M glioblastoma cells.
Head injury victims are prone to cardiac dysfunction, secondary to head injury related sympathetic surge along with other mechanisms. Neurochemistry This leads to increased incidence of hypotension both in perioperative and postoperative periods. But the extent of contribution to this 1. Identification of circulating miRNA signature for diagnosis adverse event by cardiac dysfunction is not known and its effect on of cerebral small vessel disease. Investigators: Dr. Rita outcome is uncertain. Christopher, Dr. Chandra SR (Funding by Vision group on Science and Technology, Government of Karnataka) This study is intended to examine the incidence of cardiac dysfunction and its effect in adult head injury victims undergoing Cerebral Small Vessel Disease (SVD) is the leading cause of vascular surgery within 48 hours of insult. The investigators are collecting dementia in Asian population. Identification of SVD is challenging preoperative relevant history, neurological examination findings, primarily due to limited availability of clinical expertise and diagnostic vital signs, Electrocardiography, Echocardiography and Trop-I neuro-imaging facilities. Circulating microRNAs (miRNAs) have Enzyme levels. Intraoperatively these patients undergo monitoring been proposed as diagnostic biomarkers in various disorders. The of hemodynamic parameters with Flowtrac sensor via a radial investigators performed plasma miRNA profiling by qPCR in arterial line on Edwards EV1000 platform. Postoperatively patients cerebral SVD patients and age and gender-matched healthy subjects are followed up with ECG, ECHO and Trop I levels for seven days. and found that 44 miRNAs were differentially expressed in cerebral Data collected would be analyzed for association between head SVD (p < 0.05 with a fold change of <2 and >2). injury and cardiac dysfunction.
15. Effects of transfusion on neurological outcome in patients with moderate to severe traumatic brain injury. Dr. Suma Rabab Ahmad. Guides: Dr. Umamaheshwara Rao, Dr. Rohini M Surve
The aim of this retrospective cohort study is to determine the effect of transfusion and anemia on Glasgow Outcome Scale (GOS) at discharge of patients with traumatic brain injury from hospital. Patients aged >18 years with moderate to severe traumatic brain injury admitted to ICU between May 2012 and June 2015 will be included. Parameters noted will include demographic data, all available hemoglobin values done in the initial seven days of ICU stay and blood transfusion details, other ICU data and Glasgow Coma Scale
(GCS) and GOS at discharge from ICU and discharge from hospital. Significant cluster/Heat map for four differentially expressed miRNAs using SPSS software will be used to analyze the data. DIANA TOOLS mirPath v.2.0
National Institute of Mental Health and Neuro Sciences 155 Annual Report 2015-2016
Investigators further validated a set of seven highly differentially- to modulate the expression levels of survival genes, Bcl2 and Bcl-x. expressed miRNAs in a cohort of 115 patients and 122 controls. PI-3K/AKT pathway was elucidated to underlie the anti-apoptotic Receiver operating characteristic (ROC) curve analyses showed that and survival effects of Klotho in PC12 cells. four plasma miRNAs (409-3p, 486-5p, 451a and 502-3p) could be valuable biomarkers for identifying cerebral SVD. Sensitivity and 4. Influence of CYP2C9 andVKORC1 gene polymorphism specificity for these miRNAs was 85%, 90%, 75% & 79% and 89%, in patients on oral anticoagulant therapy presenting 84%, 81% & 89% respectively. Pathway analysis revealed that these with prosthetic valve thrombosis. Investigators: Dr. SR four differentially expressed miRNAs were significantly enriched Kalpana, Professor of Pathology, Sri. Jayadeva Institute of in several biological pathways, such as transforming growth factor Cardiovascular Sciences and Research, Bengaluru, Dr. Rita beta (TGF-ß) signaling, aldosterone regulated sodium re-absorption Christopher, Dr. Nagaraja Moorthy, Dr. CN Manjunath pathway and folate biosynthesis pathways. Further validation of their (Funding by Rajiv Gandhi University of Health Sciences, biomarker potential in a larger cohort is warranted. Bengaluru)
2. Vitamin D status and vascular cognitive impairment in the Valvular heart disease is a major public health concern in India. Majority elderly. Investigators: Dr. Rita Christopher, Dr. Chandra SR of the cases are due to Rheumatic Heart Disease and are treated with (Funding by ICMR, New Delhi) valve replacement surgery with mechanical prosthetic valves. This requires lifelong oral anticoagulation, to prevent thromboembolic In this study, vitamin D deficiency was found to be highly prevalent complications. However, in spite of chronic anticoagulation post- in the elderly, and associated with hypertension [SBP (r= -0.259, surgery, some patients present with thrombosis of the prosthethic valves. p=0.01)]. Serum levels of vitamin D [25(OH)D] <12ng/ml (severe The aims and objectives of this study are to explore the contribution deficiency) was associated with 2.13-fold increase in the odds for of CYP2C9 and VKORC1 gene polymorphism in patients on oral vascular cognitive impairment (VCI) which increased to 12.5-fold in anticoagulant therapy presenting with prosthetic valve thrombosis. vitamin D-deficient hypertensives. The cytokines, TNF-α , IL-10, IL- 1α and TGF-β were measured by ELISA and correlated with serum 5. Pharmacogenetics of oral anticoagulation therapy in patients 25(OH) D levels. Pro-inflammatory cytokines, IL-1α and TNF-alpha with cardiac valve replacement. Investigators: Dr. SR were found to be significantly elevated in patients when compared to Kalpana, Professor of Pathology, Sri. Jayadeva Institute of healthy controls. Serum 25(OH) D levels were found to be significantly Cardiovascular Sciences and Research, Dr. Rita Christopher, and inversely correlated with IL-1α in the vitamin D-deficient patient Dr. CN Manjunath (Funding by ICMR, New Delhi) group (Spearman correlations r= -0.406, p=0.0001*). Genotyping for the variants of the Vitamin D receptor (VDR) gene, 25-hydroxyvitamin Chronic rheumatic heart disease is treated by valve replacement surgery D 1a-hydroxylase gene (cytochrome P450 type 27B1 (CYP27B1) and mostly with prosthetic mechanical valves which requires lifelong 25-hydroxyvitamin D 24-hydroxylase gene (CYP24A1) were carried anticoagulation therapy to prevent thromboembolic complications. out by multiplexed PCR –RFLP. Among the VDR gene variants, Acenocoumarol the commonly prescribed oral anticoagulant has BsmI BB genotype was found to be associated with 1.87-fold increase narrow therapeutic range and a wide inter-individual variability. The in the odds for VCI. Genetic variations in other enzymes involved in aim of this study was to investigate the association of polymorphisms of vitamin D metabolism did not significantly increase the risk for VCI. VKORC1 and CYP2C9 genes and acenocoumarol dose requirement. Further analysis is being carried out. The investigators found that the VKORC1 genotype distribution in patients for GG/CC, GA/CT and AA/TT were 57.6%, 36.6% and 3. A study of neuroprotective aspects of Klotho biology. 5.8% respectively. The genotype distribution for CYP2C9 for variants Investigators: Dr. Vijaya Majumdar, Post-Doctoral Fellow, 1*1*, 1*3*, 1*2*, 2*2*, and 2*3* were 78.5%, 14.1 %, 6.3 %, 0.5% and Neurochemistry, NIMHANS, Dr. Rita Christopher 0.5% respectively. The wild type of both VKORC1 and CYP2C9 (Funding by DBT) genes required a higher acenocoumarol dose as compared to mutants (p 0.023 and 0.008 respectively). Patients (44.4%) having a combination This is the first study wherein neuroprotective (anti-apoptotic and of wild type of VKORC1 with wild type of CYP2C9 required a higher survival promoting) potential of Klotho was deciphered against various dose of acenocoumarol as compared to patients (30.2%) bearing neurotoxic stimuli like serum glucose deprivation and proteasomal heterozygous VKORC1 with wild type of CYP2C9 (p value 0.008). inhibition. Expression of Klotho was found to be downregulated by Bearing a mutant allele of VKORC1 and CYP2C9 genes increased the the studied toxic stimuli in a time and dose dependent manner. Two odds of requiring a low mean dosage of acenocoumarol. clones of Klotho overexpressing PC12 cells were successfully generated. Interestingly Klotho overexpression was found to significantly reduce 6. Elucidation of the role of estrogen in the etio-pathogenesis of PC12 cell death induced by these toxic stimuli. Klotho was also found aneurysmal subarachnoid hemorrhage (aSAH). Investigators:
156 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Dr. Shruthi Ramesh, PhD Scholar, Neurochemistry, in patients with AD is closely associated with loss of synapses NIMHANS, Dr. B Indiradevi, Dr. Rita Christopher, Dr. and the formation of neurofibrillary tangles (NFT) containing Dhananjay I Bhat (Funding by ICMR, New Delhi) hyperphosphorylated tau in the hippocampus. In an attempt to develop tau-focussed immunotherapeutic strategies for AD, in the The objectives of this study were to determine whether genetic present study, as a first step, tauopathy model rats were generated. variants of endothelial nitric oxide synthase (eNOS) and estrogen These rats showed marked impairment in cognitive functions with receptor (ER) genes are associated with increased risk for aSAH, a significant increase in p-Tau/ t-Tau levels in the hippocampal elucidate whether the gene variants alter the bioavailability of nitric homogenates. To carry out the immunoneutralization studies, oxide (NOx) in the vascular system and lead to vasospasm and to polyclonal antibodies were generated in rabbits against N-terminal identify whether the gene variants distinguish genetically between phosphopeptides of Tau. When passive immunization studies small and large ruptured aneurysms. A total of 250 aSAH patients were conducted with these three sets of phospho-tau antibodies, and 250 healthy age and gender-matched controls were genotyped for significant improvement in learning and memory functions were eNOS4ab, 894G>T, -786T>C and ER alpha and beta polymorphisms. noted in the tauopathy model rats. These results demonstrate that Although a positive association was observed between carriers of the targeting N-terminal region of tau would be beneficial and may eNOS-786T allele and the risk of aSAH, no significant association present an effective therapeutic opportunity for Alzheimer’s disease was observed in the other eNOS variants. There was a significant and other tauopathies. difference in the genotype and allelic distribution of ER alpha (Pvu II) polymorphism. The T allele was more prevalent in cases than 9. Centre for Advanced Research – Development of ELISA and in controls (P= 0.0381; OR, 1.373; 95% CI, 1.026 to 1.837). No evaluation of the potential of 14-3-3 protein as a biomarker of significant difference was found in genotype and allelic distribution neuronal injury/ neuro-degeneration with special reference of ER beta (Alu I) polymorphism between cases and controls. to Creutzfeldt-Jakob disease. Investigators: Dr. Sarada Plasma NOx levels were significantly decreased patients with aSAH Subramanian, Prof. P Satishchandra, Dr. Anita Mahadevan, and associated with development of vasospasm. Serum MDA was Prof. SK Shankar (Funding by ICMR, New Delhi) significantly higher in patients compared to controls (P= 0.0435). The main objective of this project was to develop an in house sensitive 7. Protective role of Withania somnifera against scopolamine- assay for quantitation of 14-3-3 protein, and, to evaluate its diagnostic induced memory impairment in Alzheimeric rats. potential to detect 14-3-3 proteins in CSF as a supportive biomarker Investigators: Dr. G Visweswari, DST-SERB Young to the clinical, imaging and EEG findings in suspected cases of Scientist, Neurochemistry, NIMHANS, Dr. Rita CJD. Towards this, a minigene expressing the ‘core’ 14-3-3 protein Christopher, Mentor (Funding by DST-SERB Fast Track) was synthesized by overlapping PCR and the recombinant protein was produced by employing bacterial expression system. Polyclonal The objective of this project was to study the effect of different antibodies raised in rabbit against the purified recombinant protein fractions isolated from the medicinal plant, Withania somnifera, on were used for developing a dot blot assay with avidin-biotin technology the pathophysiological neurotransmitter mechanisms in scopalamine- for signal amplification and quantitation of 14-3-3 protein in CSF. induced dementia. The investigators found that methanol, n-hexane The results suggest the diagnostic potential of the dot-blot method and aqueous extracts of Withania showed significant protection with about 10-fold difference (p<0.001) in the CSF levels of 14-3-3 against scopolamine-induced acetylcholine deficiency by inhibiting protein between the CJD cases (n=50) and disease controls (n=170). acetylcholine esterase and activating choline acetyl transferase. These For evaluating test utility, receiver operating characteristics analysis extracts also showed neuroprotection by decreasing the glutamate was carried out. The results suggested an optimal cut-off value of 2 excitotoxicity by activating the glutamate dehydrogenase and glutamine ng/ ml. Using the cut-off value, sensitivity of 100% for definite and synthetase. Recovery in norepinephrine and dopamine levels after probable cases, a specificity of 86% when other neurological disorders treatment with the extracts was observed. Histopathological studies were considered with a positive predictive score of 88% and a negative showed neuronal death in scopolamine-induced tissues and recovery predictive score of 100% was achieved. of neuronal loss with these extracts of Withania. 10. Nano assisted C60-pyrimidine derivatives: Their synthesis, 8. Tau-focused immunotherapeutic approaches to Alzheimer’s characterization, neuroprotective and antiviral activities. disease. Investigator: Dr. Sarada Subramanian (Funding by Investigators: Dr. Srinivas Bharath MM, Dr. Devashish CSIR, New Delhi) Sengupta, Assistant Professor, Assam University, (Collaborating Institute), Dr. Shaheed Jameel, Scientist-V, Alzheimer’s disease (AD) is the leading cause of dementia, affecting ICGEB, New Delhi, (North-Eastern Institute) (Funding by more than 40 million worldwide. The cognitive impairment DBT, New Delhi)
National Institute of Mental Health and Neuro Sciences 157 Annual Report 2015-2016
The project aimed to synthesize novel pyrimidine-C60 based data emphasizes the myoprotective role of curcumin with therapeutic nano compounds followed by testing of the compounds in cell and implications in muscle diseases. aqnimal models of Parkinson’s disease (PD). The synthesis and chemical characterization of the compounds were carried out at 13. Analysis of the epigenetic regulation of red/ox mechanisms in Assam University by the PI of the North-Eastern Institute, while neurotoxic models of Parkinson’s disease: Role of chromatin the neuroprotective analysis was carried out at NIMHANS. Till modifications. Investigators: Dr. Mythri R, Post-Doctoral date, 16 pyrimidine-based compounds (nano compound precursors) Fellow, Dr. Srinivas Bharath MM, Mentor (Funding by DST, have been tested in N27 dopaminergic neuronal cell line for New Delhi) their pharmacological dose. All the compounds were non-toxic upto 250 µM in vitro. However, none of the compounds offered This project aimed to compare the morphological, transcriptomic neuroprotection against rotenone-mediated neurotoxicity in the and epigenetic alterations in the cell and animal models of cell model of PD. The investigators are in the process of testing Parkinson’s disease (PD). The PD toxin MPP+ induced cell death, few more compounds and their nano-derivatives for potential oxidative damage, altered neurite length and cell morphology in neuroprotective effects. N27 dopaminergic neurons. cDNA Microarray analysis in N27 cells indicated 848 genes up-regulated and 516 genes down-regulated by 11. Analysis of neuroprotective properties of natural compounds MPP+ respectively and these constituted several neuronal processes and their derivatives/pro-drugs in experimental models of including signal transduction pathways, ion channels etc. Enzyme Parkinson’s disease with potential therapeutic implications. assays, western blot and qPCR based experiments were carried out to Investigators: Dr. Srinivas Bharath MM, Dr. Muralidhar and validate the microarray data. Analysis of histone acetylation dynamics Dr. PS Rajini (CFTRI, Mysore), Dr. Krishna Misra (CBMR, in the MPP+ cell model indicated altered acetylation of histones H3 Lucknow) (Funding by DBT, New Delhi) and H4 in a time and dose dependent manner. These data would be corroborated in the animal model of MPTP PD. This project is aimed at analyzing the neuroprotective effects of novel curcumin bioconjugates in experimental models of Parkinson’s disease 14. Role of glutamate excitotoxicity and cytokines in invasion (PD). Among the 13 curcumin derivatives synthesized and tested, of glioblastoma. Investigators: Dr. Nandakumar DN, Dr. curcumin monoglucoside (CMG) and diglucoside displayed significant Sampath S, Dr. Vani Santosh, (Funding by DBT, New Delhi) neuroprotection in N27 dopaminergic cells against rotenone toxicity. Between the two, CMG showed better protection and amelioration of Glioblastoma (GBM) is one of the most common malignant tumours oxidative stress, apoptosis, DNA damage and lowered activation of the of the central nervous system. Despite new diagnostic techniques signal transduction pathway. Interestingly, CMG displayed improved and combined modality therapy, prognosis remains dismal. Decades bioavailability in cells compared to curcumin alone. CMG also of surgical therapy, radiotherapy and chemotherapy have failed protected rotenone-treated flies against mortality, motor impairment to drastically change survival. The addition of temozolomide to and oxidative damage. The data highlight the potential therapeutic radiotherapy median overall survival has improved from 12.1 months application of CMG. to 14.6 months. They have exceptional ability to infiltrate normal brain, often along blood vessels or nerve fibres. This feature makes 12. Generation of experimental models of muscular dystrophy: complete radical surgical resection virtually impossible and leading analysis of molecular mechanisms and myoprotection. in almost all cases to tumor recurrence. Their genetic and metabolic Investigators: Dr. Srinivas Bharath MM, Dr. N. Gayathri characteristics affecting invasive ability, alteration of immune response (Funding by ICMR, New Delhi) and the development of treatment resistance must be understood in detail to address them in a meaningful fashion. This project aimed to characterize an acute cardiotoxin (CTX) model of muscle degeneration and compare its pathological features with One of the distinguishing features of the glioma tumors is their human muscular diseases. The characterization of the CTX model diffuse infiltrative nature. Several factors are thought to contribute to has been described in the previous reports. The project also aimed the invasive and migratory properties of GBM cells, interacting with to test the myoprotective effects of the dietary polyphenol curcumin. the microenvironment and enhancing motility and invasion. Curcumin treatment offered myoprotection, increased the total glutathione content and decreased the oxidative stress in C2C12 The investigators aim at understanding glutamate excitotoxicity in myoblasts and myotubes treated with CTX in culture. In vivo, GBM and the role of cytokines on invasiveness of tumour and by curcumin treatment in a CTX model hastened myoregeneration, doing so, perhaps contribute to the understanding of the complex improved the muscle function, based on grip strength analysis and biological interactions that regulate glioblastoma migration, invasion protected muscle cells by improving the antioxidant aqctivity. The and recurrence.
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15. To explore the interaction between IL-1β receptor pathway, Diagnosis and treatment of muscular dystrophies (MDs) such as activated glutamate receptors and angiogenic signaling in Duchenne Muscular Dystrophy (DMD) and Limb Girdle Muscular glioblastoma. Investigators: Dr. Nandakumar DN, Dr. Rita Dystrophy (LGMD) is a major healthcare challenge in India. Christopher, Dr. Sampath S, Dr. Vani Santosh (Funding by Although several factors downstream of genetic mutations, such as SERB, New Delhi) oxidative stress, mitochondrial damage, calcium dynamics, signal transduction pathways, etc. have been implicated in muscle pathology, Glioblastoma, which is classified into WHO grade IV, is the most the interplay and the chronology of these mechanisms have not common primary malignant brain tumor with mean survival of 15 been completely understood. Cardiotoxin-mediated simulation months after diagnosis. Angiogenesis is associated with progression of a muscular dystrophic pathology in vitro and in vivo offers an and poor prognosis of gliomas. VEGF, a key factor of angiogenesis, is experimental model to study the pathways involved in degeneration regulated by HIF-1. Its transcription is induced by IL-1β, IL-8, IL-6 and regeneration of muscle and to evolve novel therapy for a multitude and PDGF-B. However, targeting classic growth factor pathways in of muscular dystrophy and extrapolated to the human condition to glioma has had limited success. Inhibition of VEGFR has emerged understand the role of different pathways in MDs and how they can as a potential therapy method for cancers and it has been clinically be modulated for therapy. validated with FDA-approval of Bevacizumab. Bevacizumab treatment prolongs progression-free survival in a subset of patients, 18. Circulating microRNAs: Role as molecular biomarkers in only minimal improvements in overall survival are observed and cerebral small vessel disease. Mr. Prabhakar P. Guides: Dr. patients invariably relapse. One particularly problematic adaptive Rita Christopher, Dr. Chandra SR response documented during the treatment of GBM patients with Bevacizumab is the transition to a more invasive tumor phenotype. The diagnosis of cerebral small vessel disease (SVD), the most It alters the pattern of tumor recurrence, leading to infiltrative common cause of vascular dementia and age-related cognitive tumor spread. Proposed project is based on a novel concept and is decline, depends on clinical criteria and neuro-imaging findings. The the first study of its kind to explore the potential interaction between objectives of this study are to identify the differentially expressed glutamate receptor signaling, IL-1β receptor signaling and angiogenic miRNAs in the plasma of SVD patients by qPCR profiling and signaling. This is aimed at discovery of newer role of glutamate and to determine their utility as molecular biomarkers to diagnose its receptors in angiogenic signaling pathway and glioma biology. SVD. Three miRNAs 409-3p, 376-3p and 502-3p were found to Understanding the molecular mechanisms underlying activation of be significantly dysregulated. These miRNAs are known to target glutamate receptors, IL-1β and angiogenic signaling of glioma will major pathways involved in neuro vascular pathology. Validation provide valuable insights in glioma biology which will help in the study showed that these miRNAs can potentially be diagnostic design of new combinatorial therapies for patients with glioblastoma. biomarkers for cerebral SVD.
16. Genetic and biochemical profiling of patients with glutaric 19. Expression profiling of microRNAs and elucidation of their aciduria type 1. Investigator: Dr. Kruthika Vinod TP possible role in the formation and rupture of intracranial (Funding by SERB) aneurysms. Ms. Supriya M. Guides: Dr. Rita Christopher, Dr. Dhananjaya I Bhat, Dr. B Indira Devi Glutaric acidemia type 1 is an autosomal recessive disorder of amino acid metabolism and caused due to deficiency of the enzyme Currently, there are no established molecular biomarkers for glutaryl-CoA dehydrogenase, a mitochondrial enzyme located in identifying a cerebral aneurysm or predicting its rupture. Further, the degradative pathway of the amino acids lysine, hydroxylysine the patho-mechanism of aneurysm formation has not been and tryptophan. The aim of this study is to examine the correlation understood to any significant proportion. In the present study, between the biochemical phenotype and its respective genotype and the investigators propose to identify the differentially expressed to know the prevalence of low excretes and its genotype in Indian miRNAs in the aneurysm tissue and the circulating blood of patients population. The finding from this study, will improvise the diagnostic with ruptured aneurysm and detect possible targets of miRNAs for sensitivity and specificity of neonatal screening for GA-I and in further elucidating their exact roles in the formation and rupture of addition it also helps in acquiring accurate figures on its prevalence intracranial aneurysms. in the population. 20. Exploring the possible role of estradiol and estrogen receptors 17. Generation of experimental models of Muscular dystrophy: in the pathomechanism of aneurysmal subarachnoid Analysis of molecular mechanism and myoprotection. hemorrhage. Ms. Shruthi SR. Guides: Dr. Rita Christopher. Investigators: Dr. Srinivas Bharath MM, Dr. Gayathri N Dr. B Indira Devi, Dr. Dhananjaya I Bhat (Funding by (Funding by ICMR) ICMR, New Delhi)
National Institute of Mental Health and Neuro Sciences 159 Annual Report 2015-2016
Vascular homeostasis is maintained by estrogen. Drop in estradiol They were custom synthesized and the purity (>90%) ascertained by level during menopause may cause perturbation of homeostasis in the HPLC. Polyclonal antibodies to these peptides were raised in rabbits and cerebral blood vessel wall ultimately leading to intracranial aneurysm characterized. Isoform-specific ELISAs were developed using peptide (IA) development and progression. The investigators hypothesize that antibody for capture and anti-14-3-3 protein antibodies for detection. genetic predisposition along with estradiol deficiency may trigger the inflammation cascade and this in turn may cause in the vessel wall 23. Evaluation of the mechanisms associated with neurotoxicity degeneration, focal weakening and out pouching of the vessel wall in cell and animal models and neuroprotection by natural ultimately leading to aneurysm formation and making postmenopausal products: Implications for Parkinson’s disease. Mr. Raghunath women more vulnerable to anSAH. With this background, the N. Guide: Dr. Srinivas Bharath MM(Funding by CSIR-SRF) investigators aim to evaluate the possible role of estradiol and estrogen receptors in the pathomechanism of aSAH. This project aimed to understand the biochemical effects of neurotoxins such as manganese (Mn) and MPTP in experimental neurotoxic 21. Role of ghrelin-leptin (im)balance on Alzheimer’s disease. models of manganism and Parkinson’s disease (PD). Acute exposure Mrs. Madhavadas Sowmya. Guides: Dr. Sarada Subramanian, to Mn in vitro in dopaminergic neuronal cells caused neurotoxicity Prof. Bindu M Kutty and elevated oxidative damage in a dose dependent manner. Mn also induced ultrastructural changes in N27 cells and lowered the Neonatal monosodium glutamate administration led to imbalance mitochondrial membrane potential. Transcriptomic analysis based in ghrelin and leptin levels resulting in obesity. Chronic status of on cDNA microarray approach demonstrated significant alterations obesity coupled with hyperglycaemia precipitated Alzheimer disease in gene expression in N27 cells and these changes were different (AD) associated changes with cognitive deficits. Artificial ghrelin from the changes induced by MPP+. Experiments based on enzyme receptor analog ([D-Lys (3)] GHRP-6), natural products (spirulina, assays, western blot, Q PCR validated the microarray data. Analysis glycyrrhizin, dark chocolate, cinnamon extract) and enriched of histone acetylation dynamics in N27 dopaminergic cells exposed environment have effectively restored the ghrelin-leptin balance and to Mn and MPP+ showed distinct changes in acetylation on histones improved cognition in these non-transgenic animal models suggesting H3 and H4. their therapeutic potential for neurodegenerative disorders such as AD. 24. Glutathione depletion induced behavioural and epigenetic changes in an animal model of oxidative stress: Implications for psychiatric disorders. Ms. Vidya K. Guides: Dr. Srinivas Bharath MM, Dr. BS Shankaranarayana Rao (Funding by CSIR-SRF)
Research evidences have indicated that psychiatric diseases share common pathways including altered neurotransmitter systems, neuro-inflammation, oxidative damage, mitochondrial dysfunction and dysregulation of genetic and epigenetic mechanisms. Among these, oxidative damage and epigenetic mechanisms require further analysis. This project aims to understand the effect of glutathione (GSH) depletion mediated oxidative stress on learning, memory and cognition in young and old rats. Administration of diethyl maleate (DEM) caused significant GSH depletion in rats (both 4-week-old and 12-week-old male wistar rats) at 6 h post injection, and the GSH levels were restored at time points 24 h and 48 h after injection. At 6 22. Recombinant expression and characterization of core h time point, 12-week-old animals showed significant depressive-line sequence of the various isotypes of human 14-3-3 protein and and anxiety-like behavior indicating that oxidative stress could induce development of isoform specific immunoassays. Mrs. Udaya behavioural changes and cognitive deficits. Kumari HB. Guide: Dr. Sarada Subramanian 25. Comparative analysis of cellular changes in Duchenne In this study, bulk amounts of ‘core’ 14-3-3 protein was obtained by muscular dystrophy (DMD), sarcoglycanopathies and using bacterial expression system. The individual linear antigenic other muscle diseases: Focus on mitochondrial function. determinants specific to each isoform of the 14-3-3 protein with Debashree Bandopadhyay. Guides: Dr. Srinivas Bharath adjoining amphipathic segments in the close proximity were selected. MM, Dr. N Gayathri, Dr. A Nalini (Funding by ICMR-SRF)
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Previous work in the laboratory employing an acute cardiotoxin and IL-6 on glioma cells, as well as their interplay with glutamate model had established the role of mitochondrial damage in muscle receptors to mediate their action. injury and degeneration. As an extension of these data, the aim of this project is to compare the changes in mitochondrial function 28. Role of glutamate excitotoxicity, TNF-alpha and IL-13 in the in different human muscle diseases including dystrophies and invasion of high grade glioma. Mr. Palaniswamy R. Guides: other myopathies. This would be carried out by histopathological, Dr. Nandakumar DN, Dr. Dwarakanath (Funding by CSIR- ultrastructural and proteomic analysis of mitochondria from cases of JRF, and DBT) Duchenne Muscular Dystrophy, Sarcoglycanopathy, Calpainopathy, central nuclear myopathy etc. Preliminary data has indicated High grade gliomas can be lethal as it infiltrates surrounding brain significant loss of activities of mitochondrial respiratory chain tissue. Glutamate uptake is reduced and excitotoxic concentrations complexes in cases of DMD and sarcoglycanopathy, compared with of glutamate are released, leading to glioma growth. Eighty percent age-matched controls. of the high-grade gliomas are positive for TNF-α and the decoy receptor for IL-13, IL-13Rα2 protein is expressed at high levels 26. Analysis of the transcriptomic and epigenetic changes in only in high-grade glioma cells. No study is available on the role 3-nitropropionic acid (3-NPA) neurotoxic model: focus on of invasion mediated by glutamate excitotoxicity, TNF-α and IL- mitochondrial function. Ms. Ranganayaki S. Guides: Dr. 13. The investigators have planned to study direct role of these on Srinivas Bharath MM, Dr. B Padmanabhan (Funding by invasion and cross talk between these molecules and its signaling UGC-JRF) pathway.
The aim of the current study is to carry out genome-wide transcriptomic analysis in cell and animal models of 3-NPA Neuro Imaging and followed by correlation of gene expression with histone acetylation/ Interverntional Radiology deacetylation dynamics. The study showed that 3-NPA, a mitochondrial complex II inhibitor could induce dose and time- 1. Functional brain connectivity in the prognosis of acute spinal dependent neurotoxicity in N27 dopaminergic neuronal cell line. cord injury. Investigators: Dr. Shriram Varadharajan, Dr. This was associated with increased oxidative stress. Histochemical Rose Dawn Bharath, Dr. AK Gupta, Dr. Anupam Gupta, Dr. staining showed altered morphology, as indicated by loss of B Indira Devi neuronal process and flattening of cells. Ultrastructural analysis revealed cytoplasmic vacuolation, mitophagy, and other markers of Spinal Cord Injury (SCI) is devastating and usually results in autophagy, altered structure of cristae. Transcriptomic analysis of significant functional impairment. Recovery from SCI is limited 3-NPA treated cells revealed extensive changes in gene expression and unpredictable as it is dependent on severity and location with more than 100 genes to be differentially expressed. Analysis of of injury, other co morbid illnesses in the patient, rehabilitative histone acetylation revealed increased global acetylation of histone measures and brain and nerve plasticity. The investigators tested H4 in 3-NPA treated cells compared with control. Analysis of whether baseline Resting state functional connectivity analysis individual acetylation sites on histone H4 and H3 would provide of the brain can be used as a biomarker for prognostication of additional information about the epigenetic regulation of gene SCI patients. Fifty three uncomplicated acute spinal cord injury expression in the model. patients were evaluated within 48 hours of injury using resting state functional connectivity (RSFC). Group ROI to ROI connectivity 27. Role ofIL1beta, IL6 and glutamate receptors in invasion differences with healthy control and within group comparisons of glioblastoma. Ms. Hurmath Fathima K. Guides: Dr. were assessed with a threshold of FDR <0.05. When compared Nandakumar DN, Dr. Sampath S (Funding by CSIR-JRF/ to healthy controls, patients with acute spinal cord injury revealed part of a funded large project (DBT)) reduced connectivity of bilateral posterior cerebellum with bilateral cortical regions. Comparing patients with and without Glioblastoma multiforme (GBM) is one of the most common primary deficits unraveled an anterior cerebellar and right temporal hyper brain tumors with poor prognosis and highly invasive behavior. connectivity proportional to the severity of injury. Correlation Glutamate has been implicated as an important player in the growth with functional recovery found left fronto-temporal and posterior and invasion of gliomas. IL-1β has been implicated in glioblastoma cingulate hyperconnectivity to be predictive of a good recovery. invasiveness. Evidence has emerged on the interplay between IL-1β These changes were dynamic with increasing bilateral cortical and and excitotoxicity in case of ischemic brain damage. In gliomas, the subcortical connectivity predominantly involving the motor cortex level of IL-6 gene expression increases with the grade of malignancy. as demonstrated in small subset of our patients who underwent a The investigators aim to look at the effect of the interleukins IL-1β repeat imaging after one month.
National Institute of Mental Health and Neuro Sciences 161 Annual Report 2015-2016
differences were assessed with a threshold of FDR <0.05. Complex FS group shows increased connectivity of areas influencing seizure induction and spread (bilateral temporal lobe and thalamocortical connections) and decreased connectivity of other cortical (precuneus, post central gyrus and left occipital lobe) and basal ganglia areas as compared to simple FS group. These connectivity differences correlated linearly with recurrent episodes of febrile seizures, duration of febrile seizure episode and disease duration demonstrating for the first time the impact of these variables in children with febrile seizures using imaging.
Significant ROI-ROI connectivity between patients with motor complete (ASIA A, B) and incomplete (ASIA C, D) cord injuries with those with no deficits (ASIA E). Mean images of ASIA E are shown in left column, those of patients with motor deficits are shown in middle column and differences in connectivity are shown in right column. With seeds placed in bilateral anterior cerebellum (top 2 rows), patients with motor complete cord injury show increased bitemporal connectivity (R>L). With seeds placed in right superior parietal lobule (third row) and right inferior frontal gyrus (bottom row), patients with Brain connectivity differences between the Simple and Complex FS (Complex incomplete cord injury increased subcortical and right temporal connectivity > Simple) for seeds (a) left middle temporal pole and (b) right middle with no obvious cerebellar changes. temporal pole which reveals the temperothalamo cortical hyperconnectvity of these seeds in children with complex febrile seizure when compared to simple febrile seizure group. Resting state fMRI can visualize time and area dependent schedules of brain plasticity as the brain recovers from SCI. Several areas in Resting state fMRI can visualize the network abnormalities in cerebellum and temporal lobes transiently support recovery in the children with complex febrile seizures. Temporothalamo cortical hyper-acute phase of the illness. hyperconnectivity seen in complex FS group is proportional to the frequency and duration of febrile seizures. 2. Resting fMRI visualizes network abnormalities in children with febrile seizures. Investigators: Dr. Ullas V, Dr. Rose Dawn 3. Disrupted small world brain connectivity correlates with Bharath, Dr. AK Gupta, Dr Jitender Saini, Dr. PS Bindu. genetic polymorphisms in children at risk for alcoholism. Investigators: Dr. Ramesh, Dr. Bharath Holla, Mr. Rajanikant Febrile seizures is the most common cause for childhood seizures Panda, Dr. Meera Purushotam, Dr. Venakatasubraminan, Dr. occurring in approximately 2–5% of Caucasian and Indian children Rose Dawn Bharath, Dr. Bharath Biswal, Dr. Vivek Benegal within the age group of 6 months to 5 years and in the absence of any CNS infection. The investigators aimed to study and compare resting Susceptibility to alcoholism is likely to be linked to a state functional connectivity patterns between patients of simple neurodevelopmental lag phenomenon in individuals at high risk febrile seizures and complex febrile seizures. Twenty four subjects to develop alcoholism. The present study aimed to investigate pre- with febrile seizures (FS) in the age group of six months to five years existing brain dysfunction in high-risk offspring from multiplex were prospectively recruited and divided into age and sex matched alcohol dependence families in terms of global organization of brain groups consisting of 11 patients in the Simple FS group and 13 functional networks by using resting-state fMRI in the context of patients in the Complex FS group. Group seed to voxel connectivity brain maturation across the COMT gene polymorphism.
162 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Simultaneous EEG fMRI has provided complementary evidence for a widespread recruitment of identical brain regions in temporal lobe epilepsy which is the prototype of clinically localized epilepsy.
5. Non accidental injury (NAI): Imaging helps suspect and identify it in pediatric patients attending NIMHANS casualty. Investigators: Dr. Hima Pendharkar, Dr. SR Chandra (Funding by ICMR)
Neurological Rehabilitation
1. Study of Urodynamic profile in patients with ‘Parkinson’s Subjects who were homozygous for COMT gene showed significantly Disease’ and ‘Progressive Supra-nuclear Palsy’ with bladder reduced clustering (γ) between nodes, longer path length (λ) and reduced dysfunction. Investigators: Dr. Anupam Gupta, Prof. small-worldness (σ) in bilateral tempero-fronto-cingulate regions compared to those subjects who were heterozygous. The regions with significantly Pramod Pal, Dr. Meeka Khanna reduced clustering coefficient are depicted in the above figure. The aim of the study is to assess the prevalence of neurogenic 4. Simultaneous fMRI EEG visualizes network abnormalities bladder dysfunction in cases of Parkinson’s disease and Progressive in temporal lobe epilepsy. Investigators: Dr. Chaitanya, Dr. P Supranuclear Palsy. Their bladder dysfunction management will be Satish Chandra, Dr. Sanjib Sinha, Dr. Rose Dawn Bharath, based on the Urodynamic findings. So far 13 patients have been Dr. Kaushik Kumar Mazumdar assessed. The investigators aim to recruit 40 patients.
Once considered focal in nature temporal lobe, epilepsy is now beginning 2. Study of sexual dysfunction and sexual concerns among persons to be better understood as a network abnormality. The investigators with disability due to myelopathy; assessment of unmet need aimed to study and compare resting state functional connectivity using for rehabilitation services and development of a hospital fMRI and EEG in patients with temporal lobe epilepsy. Forty four based sexual rehabilitation package. Investigators: Dr. Meeka subjects with Temporal lobe epilepsy (TLE) in the mean age group of Khanna, Dr. Anupam Gupta, Dr. AB Taly (Funding by ICMR) 24.5 years were prospectively recruited and were compared with age and sex matched healthy controls. Graph theory analysis of resting Comprehensive neurological rehabilitation should address sexual state fMRI and of the EEG during the IED period were done with function of affected individual to allow them the highest level of a threshold of FDR <0.05. TLE had decreased Clustering coefficient function and quality of life. Sexuality of disabled people is not (CC), Path Length (PL), and small worldness (SW) and local considered important and few studies explored this issue in India. This efficiency (LE) compared to controls using fMRI in several regions in study aims to assess the sexual dysfunction and sexual concerns among bilateral frontal, occipital, temporal, and cerebellar regions. TLE during patients with myelopathy attending rehabilitation unit of a tertiary care Interictal discharges (IED) had increased CC, PL, SW and decreased hospital. At the end of study, the investigators expect to be able to LE compared to no IED period in EEG. F3, F4, F8, P3, O1, T7, Fz, describe (a) the type of sexual dysfunction in persons with disability Cz, CP1, TP10 were the regions that were significantly different. due to myelopathy (b) the various sexual concerns that these persons have and (c) the specific but unmet need for care for sexual dysfunction among these males and females. The investigators would also develop a rehabilitation package for Indian set-up, enlisting the above findings. This would help rehabilitation clinicians to address the sexual dysfunction needs of the persons with disability due to myelopathy.
3. Study of sexual functioning, sexual concerns and sexual satisfaction in patients with stroke: A non-interventional cross sectional study. Dr. Mahesh Kumar Talele. Guides: Dr. Meeka Khanna, Dr. Anupam Gupta
Measures of small worldness (SW) and local efficiency (LE) derived from fMRI Although stroke seriously affects sexual functions of patients, need for figure (a) and (c) and EEG (b) and (d), acquired simultaneously and analysed using similar methods reveals decreased SW and LE compared to controls in the counselling on the subject and studies remains limited. The aim fMRI and increased SW and LE during IED in EEG.
National Institute of Mental Health and Neuro Sciences 163 Annual Report 2015-2016 of the research project is to study the sexual functions, sexual concerns 3. Automated portable EEG system – along with Axxonet and sexual satisfaction in patients with stroke. System Technologies. Investigators: Dr. P Satishchandra, Dr. Sanjib Sinha, Mr. Chetan Mukundan, Axxonet System A cross-sectional study was completed with adults 6 to 18 months post Technologies, Bangalore (Funding by Biotechnology stroke (N = 40 men and 5 women with stroke). Participants completed Industry Research Council, a Government of India an assessment battery covering sexual functions in male and female that Enterprise) included the sexual desire activity and sexual satisfaction including their sexual concerns and unmet needs with their Barthal’s scale for activities 4. Role of CNS opportunistic infections in subsequent of daily living and hospital anxiety and depression scale. development of HIV encephalitis. Investigators: Dr. SK Shankar, Dr. P Satishchandra, Dr. Anita Mahadevan Statistics show a negative correlation between sexual functions in (Funding by NIH Funded Project Grant No:1 RO1 NSO male and female with their Barthal’s scale for activities of daily living 55628-01A2) and hospital anxiety and depression scale. 5. Development of intra-operative Electrocorticography The sample reported mild problems with sexual function. The recording electrodes for surgery for refractory epilepsy. findings suggest that individuals with mild stroke are experiencing Investigators: Dr. Sanjib Sinha, Dr. P Satishchandra, Dr. decreased participation in sexual activities post stroke and would like Arivazhagan A (DEBEL, DRDO, Bangalore and DBT) more information from the health care community on the potential for sexual changes. This project aims to develop indigenous electrodes which can be used for intra operative electrocorticography. The prototype electrodes have 4. Quality of life, cognition and functional outcome in patients been developed and are undergoing biosafety and technical accuracy with acquired brain injury following inpatient rehabilitation: studies. Once these processes are complete, these electrodes will be a prospective study. Dr. Maitreyi Patil. Guides: Dr. Anupam tested in clinical setting. Gupta, Dr. Keshav Kumar 6. Respiratory chain disorders: Phenotypic genotypic and A large number and proportion of patients suffering from acquired functional correlations. Investigators: Dr. Bindu PS, Dr. AB brain injury (including Stroke, Traumatic brain injuries and other Taly, Dr. Gayathri N, Dr. Srinivas Bharath MM, Dr. Meera Encephalopathies) have cognitive, physical and motor impairments Purushotham (Funding by Indian Council of Medical Research) depending on the severity and duration of the injury among many other factors, which adversely affect their quality of life and functional 7. TMS as a biomarker to differentiate cortical dementias. abilities including locomotion. The investigators aim to study the Investigator: Dr. SR Chandra effect of comprehensive inpatient rehabilitation in these patients in all domains. After the recruitment process, patients will undergo detailed Transcranial magnetic stimulation showed that central motor clinical evaluation and 14 physical, occupational and neuropsychology conduction time prolonged in fronto temporal dementias. There therapy sessions. Patients will be reassessed after 14 sessions with was evidence for increased cortical excitability and decreased cortical outcome measures and will be compared with initial scores to find the inhibition. This was evidenced by reduced silent period with escape effect of rehabilitation. discharges suggesting asymptomatic changes in the GABAergic system of the patients, highlighting the therapeutic role of GABA agonists in addition to serving as biomarkers in early diagnosis. In patients with Neurology AD, CMCT was normal but cortical inhibition was reduced.
1. Innovations in mental health and neurosceinces: Manpower 8. Factors determining cognitive impairment in development and translational research centre for advanced Neurocysticercosis. Investigator: Dr. SR Chandra research. Investigators: Dr. P Satishchandra, Dr. TR Raju, Dr. SK Shankar, Dr. Sharada Subramanian (Funding by 9. Role of the aldosterone synthase CYP11B2 T-344C Indian Council of Medical Research, New Delhi) polymorphism in vascular cognitive dysfunction associated with SVD. Investigator: Dr. SR Chandra 2. Towards identification of novel genes for reflex epilepsy (hot water epilepsy) triggered by tactile and temperature stimuli. 10. Genetic determinants of cognitive impairment in cerebral Investigators: Dr. A Anand, JNCASR, Dr. Sanjib Sinha, small vessel disease (SVD). Investigators: Dr. SR Chandra, Dr. P Satishchandra (Funding by ICMR) Dr. Rita Christopher (Funding by ICMR)
164 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
During the review period, 118 cases having SVD with cognitive 13. Yoga as a tool for management of FTD Questionnaire based impairment and 102 controls having SVD but with normal study on personality traits on first degree relatives of patients cognition were genotyped for the presence of SNPs in RAAS with FTD. Investigators: Dr. SR Chandra, Dr. Suresh renin-angiotensin-aldosterone system-associated and endothelial Kumar Korada nitric oxide synthase genes. The presence of SNPs ACE I/D, rs4343, rs4351, cyp11b2 -344t/C, AGT M235T and eNos (4b/4a, This study reveals that yoga has a definite role in delaying deterioration 786t/c, and 894g/t) were not significantly different in case-control in patients with behavioral variant of Frontotemporal dementia. The comparison. However, the presence of eNOS 894 TT genotype domains which remain stable compared to control are orientation, was associated with an odd ratio (95% CI, p value) of 10.79 (0.59- short term memory, and behaviour, personal care, eating pattern, 195.6). Increased ACE activity was observed in subjects with ACE outing and shopping, judgement, problem solving and personal care. DD genotype in comparison to II and ID genotype irrespective of cases and control (DD-33.16, ID-25.32, II-19.81U/L, p Value This advantage is sustained in spite of more familial cases in the yoga <0.05). Plasma NOx levels were not statistically significant in cases group, lack of deterioration in above domains considerably reduce care compared to controls. giver burden. It also delays the need for initiation of antipsychotics; therefore yoga should be added as non-pharmacological adjuvant in 11. Serial neuroimaging as a biomarker in patients with cerebral all patients with mild to moderate behavioral variant of FTD. small vessel disease showing genetic polymorphism in Renin Angiotensin Aldosterone system. Investigators: Dr. SR 14. Autonomic function testing as a measure of cholinergic Chandra, Dr. Rita Christopher, Dr. Jamuna Rajeswaran dysfunction in patients with Alzheimer’s disease. Dr. Thomas Gregor Issac, Research resident, Clinical Investigators: Dr. SR Chandra, Dr. Neelesh Gupta Neurosciences This study is the first of its kind performed in Indian population. 12. Elevated antimeasles antibody titre: An association in The study showed definite evidence for autonomic dysfunction in autoimmune encephalitis. Investigators: Dr. SR Chandra patients with Alzheimer’s disease. There is statistically significant abnormality in frequency domains parameters of HRV analysis Autoimmune encephalitis is a group of treatable non-infective suggestive of sympathetic predominance and suppression of encephalitic disorders with great clinical implications. They have a parasympathetic activity in Alzheimer’s disease group compared close resemblance to prion disease and some slow virus infections. to control group. This abnormality positively correlates with The investigators have reported the presence of significant titers disease severity. Evaluations of autonomic functions are helpful in of anti-measles antibody in some of the patients with autoimmune diagnosing early autonomic dysfunction in these patients. Specific encephalitis resulting in diagnostic and therapeutic problems. pattern of autonomic involvement favoring parasympathetic Patients with high titers (1:625 dilution) cerebrospinal fluid (CSF) involvement probably indicates additional involvement of anti-measles antibody positivity, seen in the last four years, were central parasympathetic system in addition to parietal - temporal reviewed retrospectively. The data collected were assessed using involvement. Pattern of involvement in other cortical dementias like SPSS- Statistical Package for Social Sciences Version 15.0 (IBM frontotemporal dementia where there is abnormality in sympathetic corporation) software. The groups which showed elevated anti- system was compared. measles antibody titers but did not have other parameters suggestive of subacute sclerosing panencephalitis (Group 2) were segregated 15. Neural substrates of mirror agnosia and mirror image agnosia. and compared with those who had the typical features (Group 1) Investigators: Dr. SR Chandra, Dr. Sumanth Sivaram using Fisher’s Exact Test. 16. The role of T2 perfusion in therapeutic response assessment There were 33 patients with antimeasles antibody in CSF. Group 1 of CNS Tuberculosis. Investigators: Dr. Anantharam, Dr. had 27 and Group 2 had 6 patients. Group 1 had lower age, cognitive Rose Dawn Thomas, Dr. AK Gupta, Dr. SR Chandra dysfunction, slow myoclonus, less generalized tonic-clonic seizures, and focal seizures. Group 2 patients belonged to the higher age, had 17. Long loop reflexes in evaluation of patients with FTD and significant psychosis P( = 0.02), incontinence of bowel and bladder AD. Investigators: Dr. SR Chandra, Dr. Mahesh (P = 0.0001). Slow myoclonus was significant in the first groupP ( = 0.028), and weakness was significant in the second group P( = 0.028) 18. Development of next generation sequencing based assay and double incontinence in the second group (P = 0.0001). Magnetic for mutation detection and carrier status identification in resonance imaging showed significant gray matter and cerebellar Duchenne and Becker muscular dystrophy. Investigator: Dr. involvement in Group 2 P = 0.005 and P = 0.028, respectively. A Nalini (Funding by DST)
National Institute of Mental Health and Neuro Sciences 165 Annual Report 2015-2016
19. Glucocerebrosidase mutation in Parkinson’s disease. 25. Modulation of clinical features and cortical excitability Investigators: Dr. Pramod Kumar Pal, Dr. Ravi Yadav following low frequency repetitive transcranial magnetic (Funding by DBT) stimulation in Writer’s Cramp and Primary Writing Tremor. Investigators: Dr. Pramod Kumar Pal, Dr. Ravi Yadav 20. Genetics of movement disorders: Genotype-phenotype correlates in ataxias and Huntington’s disease. Investigators: 26. Sleep characteristics of caregivers of patients in neurological Dr. Pramod Kumar Pal (Funding by ICMR) Intensive Care Unit. Investigators: Dr. Ravi Yadav, Dr. Girish B Kulkarni 21. Gray and white matter correlates of REM Sleep Behaviour Disorder and Psychosis in Parkinson’s Disease. Investigators: 27. A longitudinal/ Follow up comparative study of pattern Dr. Pramod Kumar Pal (Funding by ICMR) and correlations of Clinical, Imaging and Cortico-Spinal excitability changes between patients with Multiple Sclerosis 22. Assessment of brain plasticity induced by repeated Trans and Neuromyelitis Optica. Investigators: Dr. M Netravathi Cranial Magnetic Stimulation in patient with movement (Funding by ICMR) disorder using resting brain networks and connectivity. Investigators: Dr. Pramod Kumar Pal (Funding by DST) 28. Serial estimation of inflammatory markers in serum of Guillain Barre Syndrome patients to predict ongoing 23. PLA2G6 - associated neurodegeneration: A phenotypic and disease activity and recovery. Investigators: Dr. R Subasree, genotypic study. Investigators: Dr. Bindu PS, Dr. AB Taly, Dr. Rita Christopher, Dr. M Veerendrakumar (Funding by Dr. Madhu Nagappa, Dr. Sanjib Sinha, Dr. Arun Kumar NIMHANS Intramural Grant)
24. Paediatric anti-NMDAR encephalitis: A clinical, Guillain-Barre Syndrome (GBS), an acquired inflammatory electroencephalographic and follow up Study. Investigators: autoimmune neuropathy, is heterogeneous in its clinical presentation, Dr. Bindu PS, Dr. Madhu N, Dr. AB Taly, Dr. Sanjib Sinha, severity, weakness pattern, sensory dysfunction, respiratory and Dr. Anita Mahadevan autonomic involvement, electrophysiological subtypes, prognosis, recovery patterns, mortality, morbidity and outcome. The aims Anti-N-Methyl-D-Aspartate-Receptor encephalitis (NMDARE) and objectives of this project are to study markers of ongoing is an under-recognized cause of encephalopathy in children. Twenty inflammation and disease activity in serum of GBS patients by serially children (boys=3; mean age=10.25+4.7years), with monophasic/ estimating cytokines and to correlate their levels with clinical profile, relapsing-remitting neuropsychiatric illness and harbouring severity, recovery, disability scores, electrophysiology, prognosis and anti-NMDAR antibodies in serum/ cerebrospinal fluid (CSF) outcome and to investigate if ongoing disease activity as evidenced were prospectively evaluated. Mean duration of index episode by the inflammatory markers would help to decide on the number of was 36.9 ± 28.5days (range: 3-127days). Abnormal behaviour, cycles of plasmapheresis. global regression, hyperkinetic movements and seizures were universal. Salient lab observations were: abnormal EEG (20/20), 29. Role of anti-ganglioside complex antibodies in pathobiology abnormal brain MRI (3/20) and CSFpleocytosis (2/19). All of Guillain Barré syndrome: A clinical, electrophysiological received MP (30mg/kg/day, intravenous infusion, for five days). and immunological correlative study with longitudinal Plasmapheresis (n=11) or intravenous immunoglobulin (n=4) follow-up. Investigator: Dr. Madhu Nagappa (Funding by were given when symptoms were severe and therapeutic response DST) was suboptimal. Subsequently, monthly MP was administered to maintain remission. Nineteen patients were followed up for a Gangliosides of peripheral nerves are recognised antigens in Guillain mean duration of 16.68±9.5months (range: 4–39months). Three Barre Syndrome (GBS), but antibodies against gangliosides are had recurrence of partial syndrome, related to delay in pulsed MP. present in only a proportion of patients. Gangliosides that co- They maintained improvement with re-initiation of pulsed MP. localise on plasma membrane cis-interact and form novel epitopes All recovered significantly from encephalopathy and were able to called ‘Ganglioside Complexes’ (GSC) which may be antigenic resume schooling. Pre-treatment modified Rankin Score was five, targets in GBS. The studies done so far are cross-sectional, with which improved to 0 or 1 in 18 children followed-up for greater conflicting results and thus the cause-effect relation is not clear. than 6 months. The study highlights that intravenous pulsed MP This prospective study aims to determine serial expression of is effective in inducing and maintaining remission and obviates antibodies against various gangliosides and GSCs in GBS during the need for more toxic and expensive agents in Anti NMDA the acute phase and their resolution or persistence at three month encephalitis in children. follow-up. An attempt will also be made to estimate the expression
166 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 of these antibodies in cerebrospinal fluid (CSF). Their association exploring the role of Autonomic Nervous system and HWE, with a with specific clinico-electrophysiological subtypes, severity, and hope that this must be playing an important role in its causation. outcome will be drawn. This study will be a key step to establish the patho-biological link between GBS and anti-GSC antibodies. 34. CJD Registry. Investigator: Dr. P Satishchandra Further, the role of anti-GSC antibodies in governing the clinical improvement and response to currently available therapies viz This is an ongoing project in collaboration with the Department of plasmapheresis and intravenous immunoglobulins can be assessed. Neuropathology at NIMHANS. Initially it was funded but now it Based on these observations, one can envisage the development is a non-funded project. This registry includes probable and definite of bio-markers and specific targeted immunotherapy to hasten CJDs confirmed histopathologically. The investigators are also part of recovery, particularly in those with severe weakness resulting in ‘Surveillance of CJD in India’ under the Ministry of Health. respiratory muscle paralysis. 35. HIV and nervous system. Investigator: Dr. P Satishchandra 30. Genetics and Epilepsy. Investigator: Dr. P Satishchandra This is an ongoing project. So far, more than 1500 patients with Following projects are being undertaken in collaboration with the Neuro AIDS / HIV infection are being evaluated at NIMHANS. Molecular Genetics Department of Jawaharlal Nehru Center for Nearly 140 autopsies have been carried out in collaboration with the Advanced Studies at Bangalore: After getting two loci for this unique Department of Neuropathology. These materials are being processed type of reflex epilepsy; Hotwater Epilepsy – one Chromosone 10q21- and analyzed to understand various OIs. The data on Cryptococcal 23 and another at 4q 24-28. The investigators are continuing the next meningitis, and work on Toxoplasmosis, PML have already been phase of Gene hunting in these regions. They have recently identified published. CNS Tuberculosis associated with HIV infection is being gene – Glutamate Transporter gene for the causation of Hot-Water studied. The investigators have just completed a non-funded study epilepsy on chromosome 9q. Further work is going on this direction. of ‘An approach to focal brain lesions associated with HIV clade C infection’. Interesting association with HIV and Sino-Venous Pharamaco-genetics is an upcoming field in epilepsy. They have started thrombosis, Lymphoma and Neurosypilis has been established. the research work in looking at ‘Pharmaco Genetics of Intractable Seizures’ and ‘Genetics of Refractoriness of Epilepsy’ in collaboration Another interesting area is ‘Neuro IRIS’. This is a new area yet to with JNCASR, Bangalore and Institute of Bio Informatics, Bangalore. be understood among the scientific community. The investigators are finding cases of patients with their condition worsening on HAART 31. Pregnancy and Epilepsy. Investigator: Dr. P Satishchandra with very high CD4 cell count – a paradoxical reaction. Cases of TBM, Tuberculoma, Cryptococcus Meningitis, PML, etc. have been This is one of the commonly debated problems. Owing to the found. The project is being taken up this year as a new initiative for problems involved in this area, and sparse literature especially from further study. India, the investigators are looking at the teratogenicity of AEDs, and successful pregnancy among epileptics. 36. The role of iron in the etiopathogenesis of Parkinson’s disease. Ms. Rajini NM. Guides: Dr. Pramod Kumar Pal, Dr. 32. Reflex Epilepsy. Investigator: Dr. P Satishchandra Rita Christopher, Dr. AK Gupta, Dr. Rose Dawn Bharath
Reflex epilepsies are interesting variety of seizures/epilepsy classified This is an attempt to understand the role of iron in the pathophysiology as a separate group under the proposed International classification and molecular events underlying neurodegeneration in Parkinson of seizures/epilepsy. These could be used as a model for further disease (PD). This study aims at comparing possible disease markers understanding the mechanism of epilepsy in general. Hence a study (serum levels of iron, oxidative stress markers and advanced MRI has been undertaken to evaluate these reflex seizures by Autonomic for detection of iron) in a comprehensive way in a large cohort of function tests, Electrophysiological followed by Inter Ictal/ ictal PD patients in a case control manner, and further to correlate these SPECT scan. This would help in the process of understanding the findings with the clinical findings. pathophysiological mechanisms. 37. A study on the phenotypic and genotypic spectrum of POLG 33. Autonomic nervous system and Hot Water Epilepsy. related disorders. Dr. Chetan Kashinkunti. Guides: Dr. Investigator: Dr. P Satishchandra Bindu PS, Dr. Gayathri N
Hot water epilepsy an interesting variety of reflex seizures is being This study on POLG related disorders, first of its kind from India studied for more than two decades. Currently, the investigators are showed heterogeneous phenotypes in a cohort of patients with
National Institute of Mental Health and Neuro Sciences 167 Annual Report 2015-2016 mitochondrial disorders. Analysis of phenotypes associated with each, while BAER was abnormal in 15. Among MEFs, responses to two pathogenic mutant alleles showed chronic progressive external somatosensory stimuli were more consistently recorded compared ophthalmoplegia as the most frequent phenotype. The homozygous to visual and auditory evoked fields. Observations regarding p.L304R mutation in the exonuclease domain of POLG1 emerged amplitudes and latencies of visual, auditory and somatosensory as the most frequent mutation in this cohort as previously reported MEFs in patients differed variably from controls and abnormalities in patients of Asian origin. However, the most common mutation were more frequent in somatosensory evoked fields. Correlation reported in European population, the p.W748S mutation in cis with with disease severity was rather poor. This study opens new vista in p.E.1123G was identified only in a single patient. Interpretation of MEG technology. the heterozygous variants in POLG1 identified in the study remains a challenge and needs to be tested in Indian population to ascertain the pathogenicity.
38. Mutational analysis of mitofuscin gene (MFN2) in axonal charcot marie tooth disease. Dr. Ramesh Siram. Guides: Dr. Bindu PS, Dr. Yasha TC, Dr. Monojit Debnath, Dr. Madhu Nagappa
Isolated or predominant neuropathy due to mitochondrial cytopathy or ‘mitochondrial neropathies’ are emerging as an important subset of inherited neuropathies. Mutation in one gene Mitofucin-2 (MFN2) encoding a mitochondrial membrane protein that promotes membrane fusion has emerged as the most common genetic defect causing axonal Charcot-Marie Tooth disease. This study aims to explore the role of MFN2 mutations in patients with inherited axonal neuropathy from India.
39. Sleep profile in patients with idiopathic generalized and symptomatic partial epilepsies. Dr. Saraswati N. Guides: Dr. Sanjib Sinha, Dr. Taly AB, Dr. Madhu Nagappa
40. Sleep in drug resistant temporal lobe epilepsy: A questionnaire, EEG and polysomnography based study. Dr. Sai Deepak Y. Guides: Dr. Sanjib Sinha, Dr. Taly AB, Dr. Madhu Nagappa (‘Golden Jubilee Fund’ from the Department of Neurology, NIMHANS) Figure shows a patient of Wilson’s disease undergoing MEG recording in magnetically shielded room (A). Averaged Somatosensory evoked field (SSEF) 41. Inter-relationship of sleep and epilepsy using macro and in whole head plotter view from all magnetometers (B), butterfly plot of microstructural Polysomnographic signal analysis. Dr. averaged SSEF (C), spatial topography of magnetic field lines at M20 (D, arrow indicates the direction of dipole vector). E and F respectively represent the Chetan Nayak. Guides: Dr. Sanjib Sinha, Dr. Taly AB, Dr. dipole on the head template and patient’s MRI. Kaushik Majumdar 43. Anti-Ganglioside complex antibodies in Guillain 42. Multi-modal evoked responses and source localisation using Barré syndrome: A Clinical, Electrophysiological and Magnetoencephalograhy in Wilson’s disease. Dr. Aruna Immunological correlative study. Dr. Rahul Raosaheb Ramani K. Guides: Dr. Taly AB, Dr. Sanjib Sinha, Dr. Wahatule. Guides: Dr. Taly AB, Dr. Anita Mahadevan, Dr. Jitender Saini, Dr. Madhu Nagappa (‘Golden Jubilee Fund’ Monojit Debnath, Dr Madhu Nagappa ( ‘Golden Jubilee from the Department of Neurology, NIMHANS) Fund’ from the Department of Neurology, NIMHANS & ICMR Grant) This prospective exploratory study for the first time analysed magnetic evoked fields (MEFs) and conventional evoked responses This prospective study aims to understand the role of ‘Ganglioside in 28 patients with Wilson’s disease using Magnetoencephalography Complexes’ (GSCs), novel epitopes and antigenic targets, in patients (MEG). Conventional VEP and SSEP were abnormal in 6 patients of Guillain–Barré syndrome (GBS) and correlate clinically. One-
168 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 hundred-and-thirty patients (M:F 2:1, mean age: 37.5+17.9years, 2. Evaluation of Cysticercal kit for Immunodiagnosis of CNS mean symptom-duration: 8.45+6.2days) have been recruited. neurocysticercal infection. Investigator: Dr. Shripad A Patil Antecedent events were noted in 50, commonest being acute (Funding by DBT) gastroenteritis. A distinct surge in the number of cases and disease severity was noted during monsoon and winter. Ten patients 3. To study the immune markers in MS: Auto antibodies, required mechanical ventilation. ‘Primary demyelinating’ was the cytokines and cell culture studies. Investigator: Dr. Shripad commonest electrophysiological subtype. Analysis of expression A Patil (Funding by DST) patterns of anti-GSC antibodies and correlation with specific clinico- electrophysiological subtypes, severity, and outcome at hospital 4. Evaluation of cysticercal infection in North East Region. discharge is underway. Investigator: Dr. Shripad A Patil (Funding by ICMR)
44. Neuropsychological assessment, VBM and Quantitative 5. Whole genome sequencing analysis of Mycobacterium DTI in ALS. Dr. Gunjan Kumar. Guides: Dr. A Nalini, Dr. tuberculosis clinical isolates from extra pulmonary Chandrajit Prasad. tuberculosis patients. Investigators: Dr. R Ravikumar, Dr. P Satishchandra, Dr. Keshava Prasad, Dr. Akhilesh Pandey 45. Observational study of magneto encephalography (MEG) (Funding by DBT) in absences and juvenile myoclonic epilepsies. Dr. Veeranna MG. Guide: Dr. P Satishchandra (Funding by Golden Extra pulmonary tuberculosis, especially tubercular meningitis Jubilee Fund) is one of the chronic infections of central nervous system. Thorough study of Mycobacterium tuberculosisis is needed to 46. Characterization of autonomic function in Alzheimer, confirm the different types of strains causing infections in general Diseases _ an electrophysiology assessment. Dr. Neelesh population. As conventional and automated methods used to Gupta. Guide: Dr. SR Chandra identify this bacterium are not specific enough to give strain level identification, deep whole genome sequencing is required 47. Non-motor manifestations of genetically confirmed to identify these bacteria and also to study the drug resistance autosomal dominant spinocerbellar ataxia. Dr. Vinayakumar pattern of the same. S Mastammanavar. Guide: Dr. Pramod K Pal 6. Development of novel antimicrobial agents to overcome 48. Behavioral profiles of fronto-temporal Dementia and microbial resistance. Investigators: Dr. R Ravikumar, Dr. correlation with structural pattern of brain degeneration. Dr. Jayanth Haldar Bineesh C. Guide: Dr. PS Mathuranath Microbial pathogens are widely becoming resistant to the existing 49. Balance and gait impairment in subjects with Frontotemporal drugs and this has turned out to be a major global health problem. dementia-A case control study. Mr. Selvaganapathy. Guide: The aim of the study is to understand the mechanism of their Dr. SR Chandra, Dr. Srikala Bharath resistance and try developing novel strategy to increase the efficacy of the existing drug and developing new drugs, to tackle the infectious 50. Ocular myasthenia: A study of clinical profile, Facial muscle diseases caused by these pathogens. The investigators are working repetitive nerve stimulation test, SFEMG and disease towards the chemical modification of antibiotics such as penicillin, activity. Dr. A Krishnan. Guide: Dr. M Veerendra Kumar vancomycin, aminoglycosides to overcome the inherent resistance of the parent drugs and achieve enhanced efficacy against drug 51. Correlates of Motor disability and fatigue with alterations resistant bacteria. The group is also actively involved in developing of cortical excitability and gray and white matter changes in synthetic peptidomimetics as therapeutics and addressing the issues multiple sclerosis and neuromyelitis Optica. Dr. Sreevidya (such as toxicity, location specific delivery, in-vivo activity, and LK. Guide: Dr. Pramod Kumar Pal most importantly the cost of production) associated with natural antimicrobial peptides. Different classes of antimicrobial agents synthesized in the lab showed impressive antibacterial activity Neuromicrobiology against different bacteria (both Gram positive and Gram-negative) including the drug resistant species like MRSA and VRE etc. The 1. Evaluation of TB kit for Immunodiagnosis of CNS investigators will test their antibacterial efficacy against clinical tuberculosis infection. Investigator: Dr. Shripad A Patil isolates of different bacteria. The antimicrobial agents synthesized (Funding by DBT) in the lab is being analyzed for their in-vitro antibacterial activity
National Institute of Mental Health and Neuro Sciences 169 Annual Report 2015-2016 and the ones with impressive results will be tested in-vivo in mice complement factors and four immunoglobulins were identified. Four model with a hope of taking the drug to market. complement factors were identified to be among the top 10 most abundant proteins. 7. Phenotypic identification and molecular characterization of
blandm-1 gene in multidrug resistant Gram negative bacilli 9. Prospective study of TB meningitis to search biomarkers isolated from clinical and environmental samples in a tertiary for early diagnosis in CSF/Blood using Mass Spectrometry neuro-care centre. Investigator: Dr. R Ravikumar based Quantitative Proteomics. Investigators: Dr. R Ravikumar, Dr. Shripad A Patil, Dr. Suman Thakur Carbapenemase-producing enterobacteriaceae isolates have been increasingly identified worldwide. Though molecular data regarding Meningitis represents one of the common infectious based issues New Delhi metallo-beta-lactamase-1 (NDM-1) producers are under Central Nervous system diseases. Tuberculous and cryptococcal available, data regarding their rate of infection in a hospital setting meningitis form the predominant etiological basis of chronic and percentage among different clinical isolates are scarce. Hence, meningitis. Patient treated in early stages of the infectious are 5 this study was undertaken to determine the occurrence of blaNDM-1 times more likely to recover. Rapid identification and diagnosis is gene among clinical isolates of multidrug resistant Gram-negative thus helpful. Biomarker search can be targeted using differential bacilli (MDRGNB) in a tertiary care center in Bangalore, Karnataka, quantitative proteomics approach. The molecules found to be India. A total of 74 MDRGNB isolates were studied. These were differentially expressed can be independently validated and developed screened for MBL production by phenotypic assays such as double as a biomarker which can aid in faster diagnosis. disk synergy test (DDST) and Modified Hodge’s test (MHT). PCR was performed for the molecular detection of the gene and 10. Neurobrucellosis- microbiological and clinical correlation. antibiograms were confirmed by automated bacteriology system. Of Investigator: Dr. Nagarathna (Funding by ICMR) the 74 MDRGNB isolates, 34 were positive for blaNDM-1 gene. All isolates were resistant to aztreonam and two isolates were resistant to 11. Neuroleptospirosis-study of microbiological and clinical tigecycline. Complete resistance to the tested carbapenems was seen aspects. Investigator: Dr. Nagarathna (Funding by ICMR) in 28 (82.35%) of the positive isolates whereas variable carbapenem resistance was seen in six (17.64%) of the positive clinical isolates. Of 12. Title of project - Confirmation and molecular the total 34 PCR positive isolates, 33 (97.05%) NDM-1 producers characterization of hospital and community acquired were identified by DDST and 26 (76.47%) by MHT as producers Methicillin resistant Staphylococcus aureus (HA and CA of MBL. A high percentage of plasmid encoded NDM was noted in MRSA) by polymerase chain reaction (PCR). Investigator: MDRGNB. Phenotypic and molecular screening should be employed Dr. Veena Kumari (Funding by ICMR) along with routine antimicrobial susceptibility testing to reflect the true number of metallo-beta-lactamase producers. 13. Comparison between SACETT and SETT on the incidence of VAP in Neuro ICU. Co-investigator: Dr. Veena Kumari 8. Identification of mycobacterium tuberculosis antigens of diagnostic potential in body fluids using high resolution mass 14. The comparative evaluation of anti-nAChR, anti-MuSK and spectrometry. Investigators: Dr. R Ravikumar, Dr. Shripad A anti-LRP4 antibodies and the possible cellular mechanisms Patil, Dr. Keshav Prasad involved in the immunoregulation of human Myasthenia gravis. Mr. Suresh Chand Bokoliya. Guides: Dr. Shripad A A comprehensive analysis of serum samples for Immune complexome Patil, Dr. Taly AB (IC) from patients confirmed to have tuberculosis infection (2+ or more) has been attempted. The IC’s were enriched by using PEG 15. Etiopathogenesis of Chronic Meningitis: Biochemical extraction protocol. The final pellet was washed in PBS buffer and Analysis and Molecular Characterization of Mycobacterium was run in a SDS PAGE. Further the 13 in-gel bands were processed tuberculosis and Cryptococcus neoformans in Cerebrospinal for distaining, reduction, alkylation and digestion. All the fractions Fluid of Patients. Dr. Jyothi EK. Guide: Dr. R Ravikumar were analyzed using 120 minutes runtime on Orbitrap Fusion Tribrid mass spectrometer interfaced with Proxeon Easy-nLC 1000 Clinical diagnosis of chronic meningitis poses a dilemma and therefore, system (Thermo Scientific, Bremen, Germany). The investigators rapid and accurate laboratory diagnosis is essential to decrease the searched the data against combined human and Mycobacterium morbidity and mortality associated with the condition. TBM and protein database resulted in identification of 195 proteins. Though cryptococcal meningitis form the two leading definite causes they did not identify any peptide from Mycobacterium, 15 of chronic meningitis. For rapid diagnosis of TBM, a combination
170 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 of cell count and typing, liquid and solid culture, polymerase chain journals. NGS and TMA facilities have been established and research reaction and line probe assay are recommended. The techniques institutes across the country can make use of them. like the MALDI- TOF MS & LPA using direct CSF require further standardization and research. The MLST showed that the predominant molecular type of C. neoformans is VNI type. C. gattii is not very prevalent in the area and most of the infections are caused by C. neoformansvargrubii. The phosphoproteomics of C. neoformans was attempted for the first time in the world which revealed significant phosphorylation of many kinases required for cell cycle regulation and virulence. The knowledge derived from the study could further the understanding of signaling pathways in the organism.
16. Immunocharacterization of Cysticercal antigens with reference to cytokine production, apoptosis and antibody responses. Ms. Anupama Pai. Guides: Dr. Shripad A Patil, Dr. SR Chandra
Neuropathology
1. Genetic and protein biomarkers for epileptogenesis and pharmacoresistance in mesial temporal sclerosis and focal cortical dysplasia. Investigators: Dr. Shankar SK, Dr. Anita Mahadevan (in collabroation with Institute of Bioinfomatics)
2. Multi-institutional network programme in molecular neuro- oncology. Investigators: Prof. Vani Santosh, Prof. Yasha TC, Dr. Arivazhagan, Prof. Thennarasu, Dr. Rose Dawn (Funding by DBT) Ph TMA Facility established at NIMHANS Important findings of this multi-institutional project include: (i) identification of a 9-gene DNA methylation prognostic survival 3. Molecular profiling of Gliosarcoma. Investigators: Dr. Vani signature for GBM which can stratify patients into different risk Santosh, Dr. Arivzhagan A, (Funding by DBT) (Part of groups (ii) protein interaction studies identified activated NFkB Multiinstitutional project on molecular neurooncology) pathway to be associated with poor prognosis in high risk group (iii) identification of GBM downregulated miR219-5p as an EGFR The investigators attempted to identify distinct molecular alterations targeting miRNA in glioblastoma (iv) developing a 10 miRNA in gliosarcoma which delineate it from glioblastoma. Tumor samples GBM survival signature and (v) methylation silencing of upstream of 15 GBM and 2 gliosarcoma were utilised for the study. All the 17 autophagy inducer, ULK2, is essential for astrocyte transformation samples were subjected to whole genome gene expression microarray and tumor growth. to identify differentially expressed genes between GBMs and gliosarcomas. Unsupervised hierarchical clustering of gene expression In project 1, a tumor periphery specific gene expression signature data revealed distinct difference in the gene expression profile of has been identified. In project 2, a tissue microarray facility has been gliosarcoma and glioblastoma with 771 genes being differentially established and many novel markers have been validated. In addition, expressed between the two groups. Gliosarcomas were enriched a pro-tumorigenic function of IGBP3 and 4 has been identified. with genes of ECM-receptor interaction, metabolic, cell adhesion GBM prognostic signatures and chemo resistance pathways with molecule and focal adhesion pathways. The study demonstrates that translational potential were also identified. In the process, three gliosarcomas, while phenotypically different from glioblastomas, also patents were filed and 103 research articles/works (57 from brain have distinct molecular profile, different from glioblastomas. Novel tumor related and 46 from other work) published in peer reviewed genes in these pathways are being evaluated.
National Institute of Mental Health and Neuro Sciences 171 Annual Report 2015-2016
sets are provided only to the medical colleges teaching post graduate students of pathology and neurology. In addition, Human Brain Bank has prepared/distributed/donated nearly 41 posters (3ft X 3ft) as a public awareness initiative and these are being used regularly in the local exhibitions organized by schools and Indian Epilepsy Association and various other NGOs.
LED lights have been installed in the Human Brain Museum to conserve energy and reduce power consumption. In addition, the museum is under CCTV surveillance for security purposes. The museum has become a centre of attraction for school and college
Figure shows differences in molecular profiling on glioblastomavs gliosarcoma students and the general public.
4. Dysferlinopathies - Biochemical, morphological and Statistics of visitors to Human Brain Museum and participation in proteomic analysis. Investigators: Dr. Gayathri N, Dr. Nalini public awareness programmes is given below. A, Dr. MM Srinivas Bharath (Funding by ICMR)
5. Studies on the seasonal variation in the ultrastructure of the renal sex segment of the lizard, Mubuya carinata. Investigators: Dr. M Bhagya, Associate Professor, Dept. of Zoology, University of Mysore, Dr. BK Chandrasekhar Sagar (Funding by University Grant Commission, New Delhi)
The information on renal sex segment (RSS), which is an important accessory sexual organ of squamate reptiles, is scarce and fragmentary. The secretions of the RSS of the male lizard might have a role in the sustenance and maintenance of spermatozoa in the female genital tract. There is a need for understanding the structure and function of the renal sex segment and other organs including brain during breeding and non-breeding seasons in squamate reptiles. The present Activities carried out to promote & enhance neuroscience Numbers teaching experience study has been designed to examine ultrastructural seasonal variations Museum Specimens mounted & displayed 61 of the cells and sexual granules, in terms of development, maintenance Schools/colleges availed loaning Specimens facility 06 and regression correlated with plasma androgen concentration in the lizard Mubuya carinata. This study will provide comparative data that Mulligan Stained brain specimens 12 expand our knowledge of the ultrastructural variation of the RSS in White matter fiber dissected brain specimens 05 male squamates, particularly lizards. The chemical characterization of the RSS secretions will be of great evolutionary significance. Neuroanatomical Methods Initiated at Neuropathology Brain Museum: 6. Development of Neuroscience Educational Material for Popularizing Neuroscience under Human Brain Bank, A) Mulligan Staining Technique for better delineation of grey matter NIMHANS. Investigators: Dr. SK Shankar, Dr. Anita and nuclear areas. Potassium Ferrocyanide in acidic pH stained Mahadevan (Funding by ICMR) nuclear areas and cortical ribbon deep blue (Prussian blue colour) reflecting differential amount of ferrous/ferric ions. The delineation In keeping with the mandate of developing Neuroscience Educational of differential nuclei is brilliant and distinctly blue, while the white Material, a Histological Atlas of the Common Infections of the CNS, matter remained unstained. This technique enhances the boundaries along with a set of histological slides, depicting the pathological of neuroanatomical structures and useful for teaching. features and CD containing the text and photographs in the Atlas has been prepared. During the year, 51 histological sets and more B) White Matter Fiber Dissection Technique to trace the axonal pathways than 320, the booklet with CD were distributed among the medical and their association with different cortical and nuclear areas in colleges and pathology residents. As a policy, the histological slide formalin fixed human brains. This age old technique is followed to
172 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 sequentially dissect, photograph and mount the specimen for training preserve mitochondrial bio-energetic function, membrane excitability the Neuroscience students. This has been initiated with the guidance and receptors, as well as structures relevant for neurotransmitter of Dr. Nupur Pruthi, Additional Professor, Neurosurgery. During exocytosis and re-uptake. Synapse proteins correspond to many the year, Mr. Suresh Parmar, Scientist-B, ICMR project participated human disease genes and drug targets for therapeutics that modulate in dissections and also was a resource person during the workshop cognitive illnesses (Pocklington et al. 2006). Studying the loss or organized by the Department of Neurosurgery in collaboration with alterations of cerebral synaptosomal proteins can provide better Human Brain Bank. understanding of the molecular mechanisms underlying synaptic neurotransmission and plasticity of neurological disorders like 7. Mapping the protein expression of hippocampus, Amygdala Schizophrenia. Studying the proteins involved in this natural and temporal lobe in adult human brain. Investigators: Dr. process makes synaptic pruning an interesting target for therapeutic Keshava Prasad (Scientist, IOB), Dr. SK Shankar, Mrs. interventions in patients with schizophrenia. Praseeda Mol, PhD Scholar This study will help to measure the synaptosomal proteomic changes Hippocampus, an important limbic system structure located in the medial of different important areas of the normal brain and in schizophrenia. temporal lobe, plays an essential role in short and long-term memory, spatial navigation, and the regulation of emotional responses. Recent 9. Host response profile of human brain proteome in imaging studies provide substantial evidence of normal and different toxoplasma encephalitis co-infected with HIV. Investigators: neuropathological conditions of hippocampus (Kang et al, 2015). Dr. Keshava Prasad (Scientist, IOB), Dr. SK Shankar, Dr. However, proteome information using high throughput techniques can Anita Mahadevan, Mrs. Apeksha Sahu, PhD Scholar unveil thousands of novel proteins in hippocampus. Amygdala is known as a center for emotional processing, fear, motivation and memory Toxoplasma encephalitis, caused by the obligate intracellular consolidation (Mears et.al. 2016). Although a preliminary protein pathogen Toxoplasma gondii is present as a latent infection in an analysis has been reported in amygdala, detailed proteomic profile is still immunocompetent individual. In immunocompromised individuals, not explored. Temporal lobe, one of the four major lobes, is involved in reactivation of latent infection results in toxoplasma encephalitis. the processing and analysis of auditory information. It communicates Molecular changes at the protein level in the host central nervous with the hippocampus and plays a key role in the formation of system and proteins associated with the pathogenesis of toxoplasma explicit long-term memory modulated by the Amygdala. An extensive encephalitis are largely unexplored. The investigators used a proteomic study has been reported on temporal lobe associated global quantitative proteomic strategy to identify differentially neurological conditions. However, proteomic research on undiseased regulated proteins and affected molecular networks in the human temporal lobe is limited. Utilizing the advantage of mass spectrometry host during T. gondii infection with HIV co-infection. The based proteomic study the complex biochemical mechanisms involved investigators identified 3,496 proteins out of which 607 proteins in the development of these regions can be elucidated. were differentially expressed (≥1.5-fold) when frontal lobe of the brain from patients diagnosed with toxoplasma encephalitis was 8. A proteomic profile of human brain synaptosomes in compared to control brain tissues. 293 proteins were found to be Schizophrenia. Investigators: Dr. Keshava Prasad (Scientist, over-expressed, and 314 proteins under-expressed. Differential IOB), Dr. SK Shankar, Dr. Anita Mahadevan, Ms. Lathika expression of HLA-B, RHOG and SERPINA1 proteins through Gopalakrisha, Ph.D Scholar immunohistochemistry was validated, which confirmed to be consistent with mass spectrometry analysis. Differentially expressed Schizophrenia is a chronic neurological disorder. It is characterized proteins indicated deregulation of several significant processes by cognitive and emotional deterioration, with symptoms typically involved in antigen processing, immune response, neuronal growth, emerging during young adulthood. The human brain is composed of neurotransmitter transport, blood brain barrier, and myelination. estimated ∼1012 heterogeneous neurons that communicate by way of Several key modulators of Brain Derived Neurotrophic Factor were ∼1015 synapses (Pocklington et al. 2006). Synapses are characterized found to be deregulated. The global quantitative proteomic approach by a relatively simple organization of membrane structure and adopted in this study generated a comparative proteome profile of associated organelles. The basic element to study mechanisms of brain tissues from toxoplasma encephalitis patients co-infected with neuronal plasticity is the synapse. HIV. Altered processes identified in this study will enhance our understanding of pathogenesis in toxoplasma encephalitis. Synaptosomes isolated from the whole brain or certain brain regions are useful models for studying structure-function relationships 10. Proteome map of adult human pituitary glands. Investigators: in synaptic vesicle release, in response to neurotransmitters. Dr. Keshava Prasad (Scientist, IOB), Dr. SK Shankar, Dr. Synaptosomes are a particularly relevant model system as they Anita Mahadevan, Mrs. Soujanya, PhD Scholar
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The regulation of pituitary function via the hypothalamus and via intra- affecting about 1-2 person(s) per 100,000 worldwide. GBS can be pituitary connections represents a complex system. Though hormones electrophysiologically classified into three major types: (i) acute secreted from the anterior and posterior pituitary have been well inflammatory demyelinating polyradiculoneuropathy (AIDP) (ii) studied, overall information of proteins expressed in the anterior and axonal neuropathy which is further divided into acute motor axonal posterior pituitary gland is very limited. Protein expression profiling of neuropathy (AMAN) and acute motor sensory axonal neuropathy normal pituitary tissue may lead to discovery of novel proteins playing (AMSAN) and the less frequent subtype (iii) Miller Fisher an important role in the physiology of pituitary glands and can lead Syndrome (MFS). to better understanding of pituitary diseases. The investigators aimed to carry out systematic proteomic profiling of adenohypophysis and Viral and bacterial infections are frequently noted before the onset neurohypophysis from human pituitary glands using high-resolution of GBS. The frequently linked infections are due to Camplyobacter mass spectrometry. A total of 2,681 proteins, 1,001 of these are novel jejuni, Epstein Barr virus, Cytomegalovirus, Mycoplasma and Human pituitary proteins, were identified from the adult human pituitary Immunodeficiency virus. Early diagnosis of GBS and thereby early glands. 2,026 proteins were identified from adenohypophysis and treatment of the disease is required for better prognosis of the disease. 2,089 from neurohypophysis. 149 novel pituitary proteins contained GBS and paralytic rabies share common clinical symptoms such as a signal peptide. The investigators have also identified 3 proteins in symmetrical ascending paralysis, dysfunction of autonomic nervous this study which have never been reported previously in a human system, and elevated CSF protein with varying pleocytosis. Unlike tissue and 2 proteins which belong to the “missing proteins” group GB syndrome, rabies viral encephalitis is a fatal disease. Diagnosis of the neXtProt protein database. The comprehensive list of proteins of rabies requires examination of brain tissue obtained at autopsy or identified in the two pituitary lobes of the human pituitary, many for skin biopsy, antemortem confirmation through diagnosis is extremely the first time, will facilitate the better understanding of the role of this difficult. Thus, it is of great diagnostic and therapeutic implication to important gland in health and disease. identify biomarkers to distinguish between GBS and other clinically similar diseases. 11. Characterization of human pineal gland proteome. Investigators: Dr. Keshava Prasad (Scientist, IOB), Dr. There is no study for differential diagnosis between GBS and paralytic SK Shankar, Dr. Anita Mahadevan, Mrs. Soujanya, PhD rabies, according to the investigators. Therefore, this proposal to Scholar carry out comparative proteomic analysis of CSF and serum from patients with GBS and paralytic rabies disease will help to identify Pineal gland is a neuroendocrine gland located at the center of the novel biomarkers unique to these diseases, which will also aid in brain. It protects the body from the effect of toxic compounds and differentiating between these two diseases that closely mimic each regulates sleep/wake cycle, body temperature and sexual maturity other but have diverse clinical outcomes. through the secretion of melatonin. Abnormal functioning of pineal glands is known to be associated with Alzheimer’s disease and 13. Human Brain Proteome: molecular insights into regional different types of cancers. Characterization of pineal gland proteome heterogeneity and neurological disorders. Investigators: Dr. will facilitate molecular level investigations on pathophysiological Keshava Prasad (Scientist, IOB), Dr. SK Shankar, Dr. Anita conditions underlying these diseases. The investigators aimed to Mahadevan, Mr. Manjunath, PhD Scholar characterize the proteome of human pineal glands using a high resolution mass spectrometry-based approach. A total of 6,062 Human brain is considered to be the most complex organ due to its proteins were identified from human pineal glands for the first time in different cell types and its heterogeneous structural and molecular this study. Of these, 1,063 proteins contained signal peptide domain. organization. A proteomic map of different sub-regions present in the They have identified 3 proteins, which have been reported to missing brain is required for novel insights into the molecular mechanisms in neXtProt database. In addition, all the enzymes that are involved regulating neuronal maturation and to understand the pathophysiology in the biosynthesis of melatonin were also identified in this study. A of multiple forms of neurological disorders. In this study, in-depth comprehensive list of proteins identified from human pineal glands proteomic analysis of various anatomically distinct sites from human will lead to biomedical research in health and disease conditions. brain was carried out.
12. Proteomic analysis for differential diagnosis of Guillain- Various sub-regions from human brain autopsy samples were dissected Barré syndrome and paralytic rabies. Investigators: Dr. and processed for LC-MS/MS analysis. SDS-PAGE and basic Keshava Prasad (Scientist, IOB), Dr. Anita Mahadevan, Mr. Reverse phase liquid chromatography technique were employed for Peeyush Prasad, PhD Scholar protein and peptide level fractionation of the sample. Each fraction was then analyzed on Orbitrap fusion mass spectrometer followed by Guillain-Barré syndrome (GBS) is a peripheral neuropathy disorder searching the data against human protein database. Unassigned MS/
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MS spectra were then searched against translated non-coding RNA Normal ageing is associated with disturbances in sleep wake and Pseudogenes. circadian rhythm, alteration in temperature tolerance, reduction in food intake, and disturbance in fluid and electrolyte homeostasis. From ten different sub-regions analyzed so far, we confirmed Hypothalamus is the master gland which controls all the above expression of 11,280 proteins in the human brain. Of these, 1,507 function through the hypothalamo-pituitary-adrenal axis. Although proteins were found to be co-expressed in all the tissues. Subsets of several studies have evaluated the functional aspects of hypothalamic the proteins identified were found to be tissue restricted and may function, very few studies have evaluated the structural changes in be responsible for specific functions of the corresponding tissue. human hypothalamus with age. Similar analysis on the proteins found to be enriched in other regions highlighted their biological functions. The researchers This study intends to detect histomorphologic changes with found translational evidence for 383 genes, which were annotated normal ageing in the hypothalamic nuclei of different age groups as Pseudogenes and their expression varied among different brain to understand the morphologic substrate underlying physiological regions. These translated products may play an important role in the ageing in hypothalamus. development of the brain and neurobiological disorders. Similarly, protein level evidence for 35 genes was confirmed, which were termed as ‘missing proteins’ in the neXtProt database. Neurophysiology
14. Prognostic relevance of clinically relevant genetic and 1. Translational research in Amyotrophic Lateral Sclerosis epigenetic molecular biomarkers in glioblastoma. Dr. Shilpa (ALS) - Development of biomarkers for diagnosis, Rao (DM Neuropathology). Guides: Dr. Vani Santosh, Dr. monitoring disease progression and evaluation of Arivazhagan A (Pending funding from DBT) toxicity. Investigators: Dr. TR Raju, Dr. A Nalini, Dr. TN Sathyaprabha, Dr. Phalguni Anand Alladi, Dr. MM Srinivas The study, initiated this year, aims to assess the relevance of molecular Bharath (Funding by ICMR, New Delhi) markers such as IDH, ATRX, PTEN, H3.3K27M and BRAF v600E mutations, EGFR amplification and MGMT promoter methylation The investigators have previously reported a 10-fold increase in in a cohort of glioblastoma tumors and derive their prognostic Chitotriosidase (CHIT1) in ALS-CSF compared to normal-CSF significance. by quantitative mass spectrometry. ELISA was performed to confirm this observation. A significantly higher level (nearly 17 fold) as well 15. Study of the neuronal and glial changes in olfactory pathway as activity (nearly 16 fold) of CHIT-1 was found in ALS-CSF with age. Dr. Monali Dilip Sonawane, MGM Medical samples. Although other study groups have used high cohort size to College, Navi Mumbai. Guides: Dr. Aruna Mukherjee, Prof identify biomarkers, till date ours is the first study to report CHIT-1 & HOD, Department of Anatomy, MGM Medical College, as a biomarker for ALS using a large cohort of ALS-CSF samples Navi Mumbai, Dr. Anita Mahadevan, (ALS-CSF; n=84, normal-CSF; n=48). In addition, the investigators have also observed an initial surge of CHIT1 level and the enzyme Olfactory dysfunction is an early and common sign in various activity at the onset of the disease which subsides to a lesser extent neurodegenerative diseases like Alzheimer’s disease, Parkinson’s with the progression of the disease. Analysis was further extended and disease and cognitive disorder which involve pathological changes in a significant difference in CHIT level between probable and definite olfactory pathway and other areas of the brain. The little is known cases was observed. However, no significant difference was observed about the changes occurring in the olfactory pathway during the between male vs. female and bulbar vs. limb onset. normal ageing process. This study proposes to evaluate the alterations of neuronal and glial cell population in olfactory bulb, olfactory tract and olfactory cortex, hippocampus and prefrontal cortex in different age groups and evolution of neurodegenerative changes with age to better understand the morphological substrate of physiological changes seen with ageing in the olfactory pathway.
16. Ageing changes in hypothalamus. Dr. Pravin Rathod, MGM Medical College, Navi Mumbai. Guides: Dr. Aruna Mukherjee, Prof & HOD, Department of Anatomy, MGM Medical College, Navi Mumbai, Dr. Anita Mahadevan, CHIT1 levels (A) and enzyme activity (B) in N-CSF and ALS-CSF samples
National Institute of Mental Health and Neuro Sciences 175 Annual Report 2015-2016
CHIT1 levels (A) and enzyme activity (B) during the progression of disease. <6: ERN Source Localization@32ms. Figure shows brains activity in Sagittal and Less than 6 months. Horizontal sections of brain for correct and incorrect responses of Novice and Advanced Practitioners. It is noteworthy that in senior practitioners there is 2. Neural correlates of well-being associated with mindfulness an earlier and a diffuse activation of brain regions at 32ms after response. Indicates an earlier response awareness. meditation-A neuro-psycho-physiological and a neuroimaging study. Investigators: Dr. Bindu M Kutty, Dr. John P John, Dr. Seema Mehrotra (Funding by DST-CSI, New Delhi)
The investigators have demonstrated the meditation proficiency related changes in cognitive information processing. Sixty three Vipassana subjects were recruited for ERP Studies. EEG was acquired using Geodesic System 300 with 128 channel Hydrocel sensor nets, while the meditators performed cognitive task. fMRI study done using Siemens Skyra 3T MRI scanner on 22 practitioners
EEG data was analysed using EEGLAB toolbox with MATLAB scripts and ‘STUDY’ function of EEGLAB for P3-ERSP. ‘Brainstorm’ Source Localization carried out for ERN.
P3-ERSP in 200-600ms showed proficiency related theta-alpha power changes (6-10 Hz) which reflect efficient stimulus gating Connectivity differences in Rest vs. Meditation are seen. Medial frontal mechanisms in meditators. cortex connected to Middle temporal gyrus, posterior division right, Middle temporal gyrus, temporo occipital right, Superior temporal gyrus posterior division left, Middle temporal gyrus, posterior division left
3. Efficacy of combination treatment of enriched environment, physical exercise and nutritional supplementation in establishing functional recovery in ventral subicular lesioned rats. Investigators: Dr. Bindu M Kutty, Dr. Laxmi T Rao (Funding by DBT, New Delhi)
Assessment of attention using 5-Choice Serial Reaction Time Task (5-CSRTT) in Ventral Subicular Lesioned (VSL) in rats was done.
ERSP at Pz site across all groups ERSP measures indicate meditation expertise dependent reduced rise in 6-8 Hz power with a concomitant enhanced Relative quantification of learning associated genes, Arc and suppression of power >8Hz frequencies in 200-600ms post-stimulus interval. Zif mRNA levels in prefrontal cortex and hippocampus using Brown shaded areas in the right most column and bottom row indicate statistically significant power changes in lower frequencies across groups and comparative CT method following 5-CSRT task in adult male within groups respectively for both rare and frequent conditions. Wistar rats was performed.
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Factors regulating this dysfunctional system are unknown. In this study, we will be using a novel, three-pronged, multidisciplinary approach to examine regulation of the MNS in schizophrenia. This includes (a) mediating MNS activity using an emotional context, (b) examining how ANS activity (heart rate variability - HRV) regulates this mediation of MNS by emotions and (c) examining the impact of plasma oxytocin and vasopressin on this relationship.
Hundred schizophrenia patients and 50 healthy comparison subjects will undergo simultaneous transcranial magnetic stimulation and electrocardiography to measure putative MNS activity and HRV respectively. Their plasma oxytocin/vasopressin levels will be measured and they will be assessed for symptoms, social cognition and real-world functioning. Understanding the relationship between these diverse neural sub-systems has potential to inform us about novel treatment targets that can be modulated to improve the disabling SC deficits, and thus improve the quality of life of patients with schizophrenia.
5. Effect of yoga and hydriatic application on migraine – A clinical, electrophysiological, immunological study. Investigators: Dr. TN Sathyaprabha, Dr. A Nalini, Dr. TR Raju, Dr. Ragavendra Rao (Funding by Central Council for Research In Yoga & Naturopathy (CCRYN)
In the present study beneficial effect of Yoga, Hydrotherapy and Yoga +Hydrotherapy as an add on therapy over conventional care was assessed objectively by autonomic function tests - HRV, Conventional cardiac autonomic function test and immunological (Cytokines) test and subjectively by HIT-6, self-perceived benefit, headache frequency diary, visual analogue scale and SF-36 questioners in migraine patients.
This study demonstrated that following six weeks of intervention, (Yoga with conventional care(Y); Hydrotherapy with conventional The graph shows fold change in gene expression of Arc and Zif268, care (Hydro) and Conventional care only (CC) migraine patients calculated following normalization to the constitutively expressed improved significantly (p<0.001) clinically (intensity and frequency gene 18S rRNA relative to the value of ventral Subicular lesioned of headache; quality of life) in Y group; Hydro group & CC (VSL) rats. Arc gene in prefrontal cortex is upregulated 5.45±0.50 group. But when compared with conventional care (CC) only Y folds. However, Arc mRNA in hippocampus and Zif 268mRNA from group and Hydro group showed marked improvement. Reduction prefrontal cortex and hippocampus did not show significant change in in sympathovagal balance (LF/HF ratio) (p<0.01), suggestive of gene expression between VC and VSL rat brain samples. improved vagal tone with reduced sympathetic tone was observed in Y group; Hydro group and Y+Hydro group when compared 4. Exploring the autonomic and neuroendocrine regulation of to conventional group. Cardiac autonomic function, Maximum: the mirror neuron system in Schizophrenia. Investigators: Minimum ratio was improved significantly (p<0.05) in all the groups Dr. TN Sathyaprabha, Dr. Jagadisha T, Dr. Urvakhsh, Dr. TR with compared to conventional care only group. Raju (Funding by SERB – DST) 6. Cellular and molecular basis of endogenous depression Schizophrenia patients have reduced mirror neuron system (MNS) induced cognitive deficits. Investigators: Dr. BS activity, which is related to their disabling social cognition deficits. Shankaranarayana Rao, Dr. TR Raju (Funding by DBT)
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in the proposed study the investigators are planning to evaluate the effects of newer antidepressants escitalopram, reboxetine treatment and enriched enrichment on depression-induced cognitive deficits comprehensively at multiple level of neural organization namely, morphological, biochemical, electrophysiological, molecular and behavioral levels. Also, current study will explore effect of antidepressant treatment and exposure to enriched environment on cognitive functions in depressive condition. Endogenous depression resulted in abnormal hippocampal synaptic plasticity. Combination of enrichment with low dose of escitalopram ameliorated depression- Combination of enriched environment and low dose escitalopram ameliorates induced spatial learning impairment. Also, the combination restored spatial learning in depressed animals. Depressed animals showed decreased % correct choice when compared with normal animals in partially baited synaptic plasticity in depressed rats. radial arm maze. NC = Normal control (n = 10), DEP = Depression (n = 10), SA = Saline administered (neonatal) (n = 8), DEP + 1h EE = Depressed rats exposed 7. Evaluation of antiepileptic activity of medicinal plants to 1h of EE for 14 days (n = 8), DEP + 1h EE + ES = Depressed rats exposed to 1h of EE and treated with escitalopram 2.5 mg/kg, b.w intraperitoneally for in Animal models of epilepsy. Investigators: Dr. BS 14 days (n = 8). Data expressed as Mean ± SEM. One-way ANOVA Followed by Shankaranarayana Rao, Dr. Sadhana S, ICT, Mumbai Tukey’s post hoc test, ***p < 0.001 vs. NC and ###p<0.001 vs. DEP. (Funding by DST)
Epilepsy is the most common neurological disorder and even multi- drug therapy is not effective and neurosurgical procedures may be indispensable. The current therapeutic treatment of epilepsy with modern antiepileptic drugs (AEDs) is associated with several side-effects. Drugs also have low therapeutic window so it need continuous therapeutic drug monitoring and approximately 30% of the patients continue to have seizures with current AEDs therapy. Further, a large number of drug interactions seen with almost all current antiepileptic drugs make it more difficult to attain easy control on seizures. Traditional systems of medicine have been exploring number of medicinal plants as an effective treatment of epilepsy over the past centuries but so far have not got the place among the standard anticonvulsant medication because their efficacy Restoration of depression-induced aberrant hippocampal synaptic plasticity has not been established. Thus, research for finding new drugs by combination of enriched environmentand low dose escitalopram. NC= with less adverse effects and more efficacy, seems to be essential. Normal control (n = 8), DEP = Depression (n = 8), SA = Saline administered (neonatal) (n = 7), DEP + 1h EE = Depressed rats exposed to 1h of EE for Accordingly, this study focuses on the evaluation of antiepileptic 14 days (n = 8), DEP + 1h EE + ES = Depressed rats exposed to 1h of EE and potential of medicinal plants to find out the mechanism of action treated with escitalopram 2.5 mg/kg, b.w intraperitoneally for 14 days (n = 8). Data expressed as Mean ± SEM. One-way ANOVA Followed by Tukey’s for its antiepileptic activity along with possible active constituents post hoc test. responsible for the same. Extractions of plants Eclipta alba and Pistacia integerrima was used for evaluation of antiepileptic activity Depression is the most prevalent forms of chronic mental illness. and also in combination with standard antiepileptic therapy. Current treatments for depression are inadequate and progress in Further evaluation of effect of particular fraction of the extract for understanding the neurobiology of depression is slow. Depression effects of synaptic plasticity in the hippocampus is being studied. is known to cause several deficits including cognitive impairments. It has been observed that temporal lobe epilepsy is associated with Several clinical studies have demonstrated that chronic depression decreased hippocampal synaptic plasticity and the same was partially has many deleterious effects on hippocampal, cortical and amygdalar restored by chronic treatment of Eclipta alba and Pistacia integerrim. structure and function that leads to learning and memory deficits. The effect of active components of both these plant extracts on Although there are structural and functional evidences from human spontaneous recurrent seizures is being studied. studies indicating cognitive dysfunction in depression, none of the studies have examined the neural basis of cognitive deficits 8. A multimodal approach to evaluate the efficacy of enriched in depression. Studying cognitive deficits in animal models often environment in ameliorating early maternal separation helps to discern the cellular and molecular pathologies underlying stress-induced changes in brain function: A morphological, the disease and develop suitable therapeutic strategies. Accordingly, biochemical and behavioural study in rats. Investigators: Dr.
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Laxmi T Rao, Dr. Bindhu OS, Department of Biochemistry, Despite extensive studies using several animal models, the only FDA Jain University, Bengaluru (Funding by ICMR) approved drug available till date for ALS is riluzole which is an anti- excitotoxic agent which provides modest improvement in patients. The objective of the study was to decipher memory consolidation at There is a striking failure to translate experimental observations different stages of fear conditioning. It was observed that MS rats from animal models into therapies. The iPSC technology provides a explored less in the familiar home cage and increased fear to the versatile “disease in a dish” model to capture salient neurodegenerative conditioned stimuli. These rats also exhibited increased anxiety, better features when derived from ALS patients. Although 90% of the spatial learning capabilities. MS rats also showed changes in the sleep cases are sporadic in nature, most of the studies on motor neurons architecture spent more time in REM sleep than other sleep stages. derived from iPSCs are obtained from FALS patients involving gene In summary, the study showed that MS was beneficial for the spatial mutations. This project aims at deriving iPSCs from SALS patients learning but not for the emotionally challenging task. Study also tried and differentiating them into motor neurons. to understand the role of fear conditioning on sleep. Our findings on the pathomechanisms of SALS emerge out from the experiments on animal models using ALS-CSF. Till date no study reports the effect of ALS-CSF on iPSC derived motor neurons of human origin. Therefore, this study involving patient specific motor neurons will aid in better understanding of the disease pathomechanisms specifically induced by sporadic ALS-CSF. The project will lead to development of a human in-vitro model of SALS which in future will be crucial for drug screening and designing better therapeutic interventions.
10. Neurosteroids and cognitive dysfunction: Behavioral, Fear retention test: Time spent freezing was considered as an index of fear electrophysiological and pharmacological evaluation. memory, 2way ANOVA revealed significant increase in freezing behavior Investigators: Dr. BN Srikumar, Dr. BS Shankaranarayana during fear retention test compared to habituation. Mean change in freezing behavior between retention and habituation with CS- and CS+ tones Rao, (Funding by Science and Engineering Research Board,
(Interaction F5,11=3.419 ; tone-wise F5,11 =4.112). Data represented (*P<0.05, Department of Science and Technology, Government of **P<0.01 and ***P<0.001). Figure 1B: Percentage of sleep during different India) stages of sleep period. Rats spent more time in wake stage and in slow wave stage compared to REM stage during sleep period. Neurosteroids are synthesized in both neurons and astrocytes and regulate several functions in the brain including cognition. The enzyme complex of 5∝-reductase (5∝-R) and 3∝-hydroxysteroid dehydrogenase (3∝-HSD) catalyzes the formation of tetrahydroprogesterone (THP). THP and other neurosteroids are involved in several physiological functions and their alterations have been reported in many neuropsychiatric illnesses. Patients who receive finasteride (5∝-R inhibitor) treatment for benign prostatic hyperplasia or androgenetic alopecia develop cognitive dysfunction. However, the mechanisms underlying the effects of finasteride administration are not well understood. It is imperative that an animal model that mimics the clinical scenario be developed to facilitate mechanistic studies. Accordingly, in the current study, the effect of chronic finasteride administration in rats on learning and memory in the radial arm maze and water maze following chronic finasteride Marble burying behavior in NMS and MS rats. Increased marble behavior treatment will be evaluated. Further, long-term potentiation in the indicates increased anxiety in MS rats. CA1 and CA3 regions of the hippocampus will be evaluated. Sizeable populations of elderly patients who are on finasteride suffer from 9. Modeling sporadic amyotrophic lateral sclerosis using depression and altered cognitive function. The proposed study will patient derived induced pluripotent stem cells. Investigators: provide insights into the involvement of neurosteroids in cognitive Dr. K Vijayalakshmi, Dr. Phalguni Anand Alladi, Dr. TN dysfunction and will lead to the development of novel therapeutics Sathyaprabha, Dr. TR Raju, Dr. Nalini A targeting the neurosteroid system.
National Institute of Mental Health and Neuro Sciences 179 Annual Report 2015-2016
11. A behavioral, pharmacological and electrophysiological Chronic stress is known to precipitate several affective disorders evaluation following 5-alpha reductase inhibition by including depression, post traumatic disorder and anxiety. finasteride. Investigator: Dr. BN Srikumar (Funding by Prolonged stress can result in long-term deleterious effects, NIMHANS intramural seed grant) including hippocampal cell atrophy and death, which in turn result in memory impairments. Herbal drugs are known to possess Finasteride is an inhibitor of 5∝-reductase (5∝-R), which has beneficial effects on the neuronal plasticity and are emerging been used in the treatment of male pattern baldness and benign as promising treatment strategy for psychiatric disorders. hypertrophic hyperplasia. Patients who receive finasteride Accordingly, the aim of the present study was to evaluate the effect treatment show signs and symptoms of depression and anxiety after of Celastrus paniculatus oil treatment on stress-induced anxiety- treatment, which persists even after the treatment is discontinued. like behavior, spatial learning and memory impairment, changes in The cellular and molecular basis underlying this phenomenon is acetylcholinesterase (AChE) activity and synaptic plasticity in the less understood. To evaluate this, depression-like and anxiety- hippocampus. Male Wistar rats were subjected to restraint stress like symptoms following chronic finasteride treatment will be for 21 days (6h/day). Stressed rats were treated with Celastrus first assessed. Further, the effect of antidepressant treatment on paniculatus for 14 days. The investigators observed that neither the depression and anxiety will also be evaluated. Depression and stress nor CP oil treatment affected basal synaptic transmission antidepressant treatment results in electrophysiological changes in hippocampal slices (A). Chronic restraint stress resulted in such as that of long-term potentiation or long-term depression impaired hippocampal synaptic plasticity. On the other hand, in the hippocampus. Accordingly, the effect of chronic finasteride Celastrus paniculatus treatment restored CA1-LTP in stressed administration and antidepressant treatment on synaptic plasticity rats (B). Thus, the findings of the study indicate thatCelastrus will be evaluated. Changes in the content of neurotransmitters like paniculatus is a potential herbal drug for the treatment of stress- serotonin and norepinephrine are thought to be responsible for induced cognitive deficits. depression and antidepressants increase the synaptic levels of these neurotransmitters. Hence the effect of finasteride and antidepressant treatment on neurochemical changes will be evaluated. This study will deepen the understanding of the cellular changes underlying the depression and anxiety symptoms associated with chronic 5∝-R inhibition and will lead to the development of novel drugs to treat depression and anxiety.
12. The role of glia in aging and in determining neurotoxicity of 1-Methyl-4-Phenyl-1,2,3,6-tetrahydropyridine (MPTP). Dr. Phalguni Anand Alladi, SSO, Dr. TR Raju, Dr. Bindu M Kutty (Funding by DBT) Amelioration of stress-induced impaired hippocampal synaptic plasticity by Celastrus paniculatus treatment.(A) Both stress and treatment did not affect Input-output curve The role of glia in Parkinson’s disease pathology is not completely (B) Stressed animals showed decreased long-term potentiation (LTP) when compared with normal animals after high frequency stimulation (HFS) and understood yet. The investigators therefore plan to study two mice this deficit was restored by Cp oil treatment. Data is represented as mean ± strains with markedly differing susceptibility to MPTP which is a S.E.M. NC: normal control. ST: rats subjected to restraint stress for 21 days neurotoxin that recapitulates PD like symptoms in mice. The number (6h/day). ST+ VE, ST + CP-400 and ST + CP-600: stressed rats subjected to 14 days of treatment with vehicle, Celastrus paniculatus 400 or 600 mg/kg, i.p., of micro and astroglia in two mice strains i.e. C57/BL6 and CD1 respectively. One-way ANOVA followed by Tukey’s post-hoc test. white was quantified. The susceptible strain i.e. C57Bl/6 has fewer nigral neurons than the resistant CD1 mice. The investigators will 14. Modulation of neuronal cytokines (IL-2, TNF-α) and examine if the differences in numbers extend to the number of glia cytokine receptor expression due to Benzo[a]Pyrene exposure too and if the glia-mediated-neuroinflammation is responsible for in Rat Brain. Investigators: Ms. Rajeshwari Parida, Dr. TN amending the vulnerability to the neurotoxin. Sathyaprabha (Funding by DST WOS-A (SR/WOS-A/LS- 560/2012), New Delhi) 13. Effect of Celestrus paniculatus on cognitive deficits in chronically stressed rats: A behavioral, neurochemical, IL-2 and TNF-α potentially produced by neurons are associated structural and electrophysiological approach. Investigators: with hippocampus development and regulation. Benzo[alpha] Dr. Bhagya V, Dr. BS Shankaranarayana Rao (Funding by pyrene (B[a]P) one of the potent carcinogens causes physiological DST) changes in the hippocampus leading to memory dysfunction and
180 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 immune suppression of CNS. The real mechanism behind the effect of B[a]Pon cytokine production in the hippocampus is unclear. More than 50% similarity provides an insight that expression of cytokines using rat model can be of immense help while correlating their applications in the therapeutic approach for humans. Therefore, the investigators have performed experiments on the expression of neuronal cytokines in the hippocampus region of B[a]P-treated rats. IHC, WB and ELISA results have shown that B[a]P helps to induce inflammatory cytokines IL-2 and TNF-α in the hippocampus region. There is an upregulation of cytokines at 0.25 micromolar concentration as compared to controls. B[a]P induced cytokines can Points were awarded based on the following parameters: 0 points - no grip and paw slipped through the rungs, 1 point - partial grip when paw was kept serve as important biomarkers linked to immune activation during on the rung without the digits holding on to the rung and 2 points - the mid various adverse conditions. portion of the paw was placed on the rung with full support from the digits. Percentage of paw placement represented as Mean ± SD from control, stroke and short term genestein + stroke rats. Paired students t-test, ***p<0.001. 15. Combined effect of dietary Genestein and CIMT on modulation of synaptic plasticity in intracortical ischemic B Histology- Golgi-Cox staining: stroke. Dr. Sabitha K Rajesh. Guide: Dr. Laxmi T Rao (Funding by ICMR)
The effect of Genestein and constrained induced movement therapy in modulating the neurological deficits and neuronal plasticity in motor cortex, in intracortical ischemic stroke model of rat, is being studied. Unilateral administered of Endothelin-1, a vasoconstrictor, adjacent to the MCA, causes a lesion and leads to Contralateral Schematic representation of Scholl’s method for quantitative arborization of pyramidal neurons in the motor cortex. Representative neuron images Neurological deficits. Morphological studies by TTC staining after Golgi-Cox staining from A. Control, B. Stroke and C. Short-term confirmed stroke, and it was observed that genestein treatment genestein+stroke decreased the infarct volume, compared to ischemic stroke rats. Neurological deficits were assessed based on various behavioural paradigms like reach to grasp, cylinder test, horizontal ladder test as well as gait analysis. Acute administration of genestein ameliorated ET-1 induced motor impairments. There was significant improvement in skilled reaching and motor coordination in the paretic limb after acute treatment with genistein and CIMT. Besides Golgi-Cox staining demonstrates that genestein attenuated structural impairment of motor cortical neurons caused by ET-1 and enhanced structural recovery in the affected regions of the motor cortex.
A. Horizontal ladder test to access the coordinated motor movement
Branching intersections and length of dendrites represented in points as Mean ± SD from control, stroke and short term genestein + stroke rats across the radius of concentric circles as per Sholl’s analysis. The box represents the range of radii which show a significant change in intersections and length of dendrites. Paired students t-test, ***p<0.001.
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16. Evaluation of developmental apoptosis and nigral neuronal response in two mice strains with differential sensitivity to 1-methyl-4-phenyl-1, 2,3,6- tetrahydropyridine (MPTP) and their crossbreds. Ms. Jyothi HJ, JRF. Guides: Dr. Phalguni Anand Alladi, Dr. TR Raju (Science and Engineering Research Board, DST)
The study aims at unraveling the mechanisms for ethnicity based differences in prevalence of Parkinson’s disease using mice models. Expression of proteins like Tyrosine hydroxylase, Bax, Bcl-2 and Caspase 3 were studied in the nigra of the P14, P22 and adult Histograms showing the individual differences as well as the changes in the mice using immunohistochemistry. The number of neurons in number of nigral neurons during different developmental stages (A), nigral the CD-1, F1X1 and F1X2 were comparable. The most critical volume (B) and neuronal density (C), number of apoptotic cells (D) as well as observation was the absence of DA cell loss following MPTP Bax:Bcl2 ratio in the two mice strains (E&F). injection in the crossbreds. Morphologically, the neurons of the crossbreds resembled the CD1 strain. Developmental profile Response of SNpc Dopaminergic Neurons To MPTP Injection: shows that the differences indeed occur and that developmental apoptosis is a critical process.
Histograms showing changes in the SNpc of the different mice strains after MPTP injection. Note that the C57Bl/6 shows maximum cell loss in response to MPTP injection (A). The CD1 mice show relatively lesser loss, whereas the crossbreds show no loss at all. The TH expression was not affected significantly (B). The C57Bl/6 shows maximum cell shrinkage in response to MPTP injection (C&D), while the CD1 mice and admixed F1 generation did not show any effect on the soma.
Representative photomicrographs of SNpc in (A) C56BL/6, (B) CD-1, (C) 17. Glial Responses in Sporadic Amyotrophic Lateral F1X1 (F1 cross between C56BL/6 female X CD-1 male) and (D) F1X2 (F1 cross between C56BL/6male X CD-1 female). Note the differences in the Sclerosis (SALS): An in-vitro experimental study. Ms. Pooja Shree number of nigral neurons in substantia nigra pars compacta. (E) shows the Mishra. Guides: Dr. TR Raju, Dr. A Nalini, Dr. TN Sathyaprabha, immunoblots to study the expression of TH and PitX3 in the substantia Dr. Phalguni Anand Alladi (Funding by UGC, DBT) nigra.
Microglial responses in sporadic ALS models were studied. The There was no difference in the number of nigral neurons and investigators found down regulation of trophic factors VEGF m- TH expression among the crossbreds, i.e., F1X1 and F1X2; the RNA and GDNF m- RNA, while pro-inflammatory markers IL-6 investigators chose to perform the stereological and densitometric m-RNA, TNF-α m-RNA and IFN-γ m-RNA were significantly up- analysis of developing SNpc only in the F1X2 progeny, along with the regulated in microglial cultures exposed to ALS-CSF. Thus the role parent strains. F1X2 was considered for the study as it is comparable of glia in exacerbating the disease progression through excitotoxity to the Anglo-Indians, where mother is of resistant origin (CD1) and and neuroinflammation mediated mechanisms is strongly indicated. father is of susceptible origin (C57BL/6).
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Studies delineating the specific inflammatory pathways involved in glia mediated pathology are critically required. In addition, further investigations on the pathological glial and neuron interactions can lead to better understanding of the disease pathogenesis and identification of possible therapeutic targets.
VEGF m-RNA expression in the microglial cultures. qRT PCR analysis showed a down regulation in VEGF m-RNA levels in the ALS group as compared to the NC and NALS subsets (***p<0.001 NC and ##p<0.01 NALS v/s ALS; n =3 in triplicates). Analysis of significance was carried out using one-way ANOVA followed by Tukey’s post hoc test.
IL6 m-RNA expression was icreased in microglial cultures. qRT PCR analysis showed an upregulation in the IL6 m-RNA levels in the ALS group (**p<0.01 v/s NC and NALS; n=3 in triplicates). Analysis of significance was carried out using one-way ANOVA followed by Tukey’s post hoc test.
GDNF m-RNA expression in the microglial cultures. qRT PCR analysis showed a down regulation in GDNF m-RNA levels in the ALS group as compared to the NC and NALS subsets(*p<0.05 NC and NALS v/s ALS; n= 3 in triplicates). Analysis of significance was carried out using one-way ANOVA followed by Tukey’s post hoc test.
TNFα m-RNA expression in the microglial cultures. qRT PCR analysis showed 18. Directed differentiation of human embryonic stem an upregulation in the TNFα m-RNA levels in the ALS group (**p<0.01 NC and NALS v/s ALS ; n=3 in triplicates). Test of significance was by one way ANOVA cells into motor neurons, their characterization and followed by Tukey’s post hoc test. use as a cellular model for sporadic amyotrophic lateral sclerosis. Ms. R Sumitha. Guides: Dr. TR Raju, Dr. TN Sathyaprabha, Dr. A Nalini (Funding by ICMR Senior Research Fellow)
The aim is to differentiate Human Embryonic Stem Cells (HESC’s) into spinal motor neurons, characterize them and use as a cellular model for sporadic ALS. HESC’s were grown in culture and neural induction was done. Retinoic acid and sonic hedgehog agonists were added to media for motor neuron formation. From Day 17, cells were supplemented with growth factors. The neurospheres were grown on ploy L ornithine/laminin coated dishes following which spontaneous activity recorded using Multi IFNγ m-RNA expression in the microglial cultures. qRT PCR analysis showed a down regulation in the IFNγ m-RNA levels in the ALS group (**p<0.01 NC and Electrode Array (MEA) and immunocytochemistry was done. The #p<0.05 NALS v/s ALS; n=3 in triplicates). Analysis of significance was carried results of immunocytochemistry are given below and the MEA out using one-way ANOVA followed by Tukey’s post hoc test. recordings yet to be analyzed.
National Institute of Mental Health and Neuro Sciences 183 Annual Report 2015-2016
The graphs show the quantified results of area of NMJ and AchR expression. There is a significant decrease in the NMJ area in ALS-CSF group as compared to NC, Sham and NALS-CSF groups (**p<0.01NC v/s ALS). However, there is no change in the AchR subunit expression.
Confocal photomicrograph of motor neurons expressing: Day 21 of differentiation: Choline Acetyl Transferase (Red) and βIII tubulin(Blue); Day 45 of differentiation: Choline Acetyl Transferase (Red) and Microtubule associated protein 2 (Blue)
19. Pathophysiology of skeletal muscle in Amyotrophic Lateral Sclerosis (ALS) - An experimental study in a rat model. Ms. Shruthi S. Guides: Dr. TR Raju, Dr. Gayathri N, Dr. Phalguni Anand Alladi, Dr. A Nalini (Funding by CSIR Senior Research Fellow)
Representative Confocal micrographs of skeletal muscle stained for the VEGF To investigate the ALS-CSF induced changes in the skeletal muscle and GDNF. Note the significant downregulation of VEGF(**p<0.01NC v/s ALS) of rat neonates, the rat pups were intrathecally injected with ALS- and significant upregulation of GDNF (**p<0.01NC v/s ALS) in the ALS-CSF group as compared to the normal controls shown in histogram. CSF on 3rd, 9th and 14th day, and sacrificed on 16th day. Pathological changes in NMJ’s were observed in ALS-CSF injected rat pups as compared to other controls. There was a decrease in the total NMJ area indicating reduced complexity in NMJ structure in ALS; however AchR expression level remained unchanged. Further, quantification of VEGF and GDNF expression was altered in ALS group compared to the control groups suggesting impaired trophism. Additionally, ultrastructural analysis revealed severe organelle damage in ALS.
Electron microscopic images of skeletal muscle where normal control shows the polygonal shaped fibres whereas the ALS-CSF injected sample shows Representative Confocal micrographs of NMJ stained with α-bungarotoxin the rounded and angulated fibers. (Top panel). Double membraned intact (Green). Note the petzel shaped NMJ in normal control and denervated and sarcolemma is seen in normal control whereas the sarcolemma is folded in disintegrated NMJs in ALS-CSF group with reduced complexity. ALS- CSF injected rat skeletal muscle
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B. Golgi Staining:
Electron microscopic images of sarcoplasmic reticulum shows dilation in ALS- Golgi staining of lumbar region of spinal cord of P16 day old rat pups in 10x CSF injected group as compared to normal. & 40x magnification.
20. Functional impairment of motor neurons in a rat model of Sporadic Amyotrophic Lateral Sclerosis. Mr. Sanjay Das. Guides: Dr. TR Raju, Dr. Laxmi T Rao (Funding by ICMR Junior Research Fellow)
Cresyl violet and Golgi staining of spinal cord slices of P16 rat pups intrathecally infused (at P3,P9 and P14) with ALS-CSF revealed a decrease in motor neuron numbers, total area and volume along with Result of Golgi analysis showing a) a trend of increase in area of cell body b) the number of nodes. An increase in cell body diameter was also reduction in the number of nodes in the lumbar extension of P16 day old rat pups infused with ALS-CSF. evident when compared to the control groups (NC, a-CSF, NALS- CSF). Electrophysiological studies involving extracellular recording 2. Electrophysiological study (MEA recording): of NSC-34 motor neuron cell line using Multielectrode 64 channel array, upon exposure to ALS-CSF showed an increase in mean spike frequency, mean ISI in bursts, number of spikes and number of bursts.
1. Histological study A. CV Staining
Showing the spontaneous firing of NSC-34 cell line in 64 channel MEA plate
Picture showing motor neuron in the ventral horn of spinal cord slices of lumbar extension of P16 day old rat pup in 4X & 40X magnification.
Graphical representation of electrophysiological data obtained in MEA Stereological quantification of spinal motor neurons of the lumbar extension recording from NSC-34 cell line in control, cells exposed to ALS-CSF and NALS- of P16 day old rat pups after CV staining shows reduction in total area, volume CSF. Note an increase in the no. of spike, mean spike frequency, no. of bursts and number. and mean ISI in bursts in the ALS group. *P<0.05.
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21. Neural correlates of wellbeing in long term rajayoga The study demonstrated changes in sleep dynamics (altered spindle- practitioners - A multimodal study. Mr. Ajay Kumar Nair. delta dynamics) and deficits in stimulus prediction mechanism Guides: Dr. Bindu M Kutty, Dr. John P John, Dr Seema (impaired corollary discharge) among patients with schizophrenia, Mehrotra suggestive of dysfunctional thalamo-cortical information processing associated with the pathophysiology of schizophrenia, but from The study examines well-being using standard measures and different dimensions. Thus, studying brain dynamics during sleeping examines neural functions using EEG, ERP and fMRI in Rajayoga and waking states in an integrative fashion can give novel insights into practitioners (Brahma Kumaris). Long term (LTP, n=36) and Short the pathophysiology of schizophrenia. term (STP, n=25) practice groups show reduced negative affect, enhanced positive affect and psychological well-being as compared to 23. Evaluation of lucid dreaming among proficient Vipassana Zero-term practice group (ZTP, n=25). During meditation (vs rest), meditation practitioners and control subjects. Mr. Gulshan LTP show theta power changes (STP show alpha power changes and Kumar. Guide: Dr. Bindu M Kutty ZTP show no changes). During resting fMRI, STP show enhanced connectivity vs LTP. Thus, meditation provides enhanced well-being During lucid dreaming, there is enhanced awareness of the self during and state changes seen in EEG spectra. Long term practice confers REM sleep and is associated with activation of many brain areas that plasticity induced changes in neural processing. are otherwise inactive at during non-lucid REM stage. Initial studies on lucid dreaming, using polysomnography and questionnaires, have given insights into the basic psychological, polysomnographic and behavioural aspects of lucid dreaming. In the present study, we induced lucid dreams in healthy controls through Reality testing, Intention technique, Autosuggestion and by providing Acoustic stimulus. In the current study, the investigators observed increase in alpha and beta activity in the parietal and frontal regions—areas related to semantic understanding and abstract thinking respectively. Trend in increase in alpha activity in Vipassana Meditators during REM sleep suggestive of increased awareness during sleep was also observed.
Med vs Rest EEG Topographical changes in upper theta power. Red dots show electrodes with significant state changes for LTP.
REM sleep without lucid dreaming. No alpha and beta activity.
Inflated superior brain view contrast: STP show higher functional connectivity (red lines) between the displayed nodes than LTP during rest.
22. Examination of aberrant neural synchrony in schizophrenia – A multi-modal EEG, fMRI and polysomnography study. Dr. Arun Sasidharan. Guides: Prof. Bindu M Kutty, Dr. John P John (Funding by ICMR towards SRF Fellowship)
Sleep study was carried out in 45 schizophrenia patients and 39 controls. Of these, task-related EEG study was done in 23 patients and 23 controls. Task-related fMRI study was done in another set of Lucid dreaming during REM sleep. Increase in alpha and Beta activity in fronto-parietal region. 13 patients and 16 controls.
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24. Behavioral validation of cognitive dysfunction in a rat model of schizophrenia. Ms. Neethi Prem. Guides: Dr. Bindu M Kutty, Dr. Laxmi T Rao, Dr. John P John (Funding by NIMHANS)
Schizophrenia (SZ) is a neuropsychiatric disorder that afflicts around 0.5%-1% of the world’s population. Neonatal Ventral Hippocampal Lesion (NVHL) Model is one of the well-established animal models of schizophrenia. Cognitive symptoms such as deficits in attention, memory and executive functions, which are prefrontal cortex dependent said to be primary defects in SZ which occur from childhood till the end of life. The investigators are studying single unit activity of medial prefrontal cortex neurons during an ongoing value-based decision making task in NVHL model. Preliminary single unit activity from prefrontal cortex (Prelimbic Area) is shown below. Indicates significant improvements in cognitive aspects such as concentration, memory work efficiency, etc. in senior practitioners when compared to novices.
25. Vipassana meditation and Well-Being: A neuro-psycho- physiological- study. Dr. Ratna Jyothi. Guides: Dr. Bindu M Kutty, Dr. Ravindra Panth, Dr. Seema Mehrotra (Funding by Department of Science & technology – Cognitive Science Research Initiative (DST-CSI), New Delhi) Indicates improvement in composite well-being (Development of wholesome qualities, reduction of unwholesome qualities, general & social health) with increase in meditation proficiency. The Buddhist model of well-being has been proposed by the investigators. Psychological questionnaires based on Buddhist 26. Assessment of EEG in practitioners of vipassana meditation: concepts of well-being were developed. A total of 107 novices, 18 A non linear analysis. Mr. Rahul Venugopal. Guides: Dr. mid-term practitioners, and 110 senior practitioners participated in Bindu M Kutty, Dr. Prasanta Kumar Ghosh (Funding by the survey. NIMHANS)
Statistical analysis of the survey with appropriate tests showed EEG signals may be considered as an emergent phenomenon, the following results: (a) development of wholesome qualities (b) the quantification of the complexity of a system is one of the aims reduction in unwholesome qualities (c) general and social health of non-linear time series analysis. The complexity of the system improvement (d) improvement in cognitive aspects (e) improved can be characterized by complexity measure computed from the restraint in conduct. signals generated by the system. The complexity is associated with unpredictability. The study aimed at exploring the time domain Correlation studies indicated positive correlations between meditation approach for the study of complex behavior of electrical activity proficiency and well-being. of brain during Vipassana meditation using nonlinear methods.
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Permutation entropy and fractal dimension are two nonlinear parameters that reflect the inherent complexity and self-similarity patterns respectively. The results show that the complexity measures show a decreasing trend with meditation proficiency in Vipassana meditators. The algorithms are computationally fast and intuitive.
Effect of Ventral Subicular lesion on time spent in a) Closed and b) Open arms in the elevated plus maze. Lesioned animals showed a high component of anxiety as evident by the reduced time spent in the open arms and more time in the closed arms. Data expressed as Mean ± SEM. *p<0.02, One-way ANOVA followed by Dunnett’s Multiple comparison test.
Topoplot of permutation entropy values
Animals subjected to ventral subicular lesion exhibited high anxiety-like behaviour in light-dark test. Ventral subicular lesioned animlas showed significantly enhanced anxiety-like behaviour by spending less time inthe light chamber (a), more time in the dark chamber (b), increased latency to Topoplot of fractal dimension values dark chamber (c) and reduced inter-chamber transitions (d). Data expressed as Mean ± SEM. *p<0.01; **p<0.01, One-way ANOVA followed by Dunnett’s 27. Ventral Subiculum and Anxiety Behaviour: Role of circadian Multiple comparison test. desynchrony on ventral subiculum lesion-induced anxiety behavior. Mr. Subhadeep Dutta Gupta. Guides: Dr. Bindu 28. A study to identify potential biomarkers in Diabetic M Kutty, Dr. BS Shankaranarayana Rao (Funding by Peripheral Neuropathy. Ms. Anu P John. Guides: Dr. TN NIMHANS and DBT) Sathyaprabha, Dr. Anita Mahadevan, Dr. R Anil Kumar
Ventral subiculum, the output component of hippocampal formation, The study proposes to explore the association between autonomic has been implicated in several cognitive functions including fear function, intraepidermal nerve fibre density changes, and various and anxiety behaviours. These behaviours are known to be regulated biochemical parameters (Serum sFas and Gamma glutamyl by amygdala through activation of hypothalamo-pituitary-adrenal transferase) to identify potential biomarker/s for diabetic peripheral axis. In the study, the investigators have demonstrated that bilateral neuropathy. The autonomic function (heart rate variability, cardiac ventral subicular lesion induces neurodegenerative changes in the autonomic function and quantitative sudomotor axon reflex) in paraventricular nucleus, ventromedial and dorsomedial nucleus of pre-diabetics, diabetics, diabetics with peripheral neuropathy and hypothalamus. Prolonged exposure to dark housing condition led healthy controls will be assessed and compared with intraepidermal to alterations in feeding behaviour and increased body temperature. nerve fibre density variation, and the biochemical values of glycated Interestingly, the neurodegenerative changes in the hypothalamus haemoglobin and serum levels of soluble Fas and gamma glutamyl were associated with reduced anxiety in the ventral subicular lesioned transferase to identify a potential biomarker/s for early detection of rats upon exposure to altered light-dark cycle. The understanding of diabetic peripheral neuropathy. cellular and molecular basis of anxiety, cognitive and visceral functions by the ventral subiculum and hypothalamus might help in developing 29. Autonomic, biochemical and clinical profile of probable novel strategies to treat affective and neurodegenerative disorders multiple system atrophy (MSA). Dr. Rukmani MR. Guides: including Alzheimer’s disease. Dr. TN Sathyaprabha, Dr. Ravi Yadav, Dr. Binukumar B
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No reliable biomarker exists for the diagnosis and prognosis of MSA Stereological analysis showed stress-induced hypotrophy of the despite research. To more thoroughly phenotype MSA cases with dentate gyrus and hippocampus, and hypertrophy of basolateral validated rating scales and questionnaires and relate the severity amygdala which were restored by chronic escitalopram treatment. of clinical symptoms to biomarker, finding a reliable biomarker is The reversal of structural and behavioral changes was associated essential. Assessment of HRV, BPV, BRS, conventional cardiac with restored expression of brain derived neurotrophic factor autonomic function tests, Tilt table test, rate corrected QT intervals, (BDNF) and vascular endothelial growth factor (VEGF) in the objective clinical scales of disease progression and serum alpha hippocampus and frontal cortex. In contrast, up-regulated levels synuclein at baseline and at follow-up intervals and correlation of of neurotrophins in the amygdalar complex were not reversed by these parameters with each other helps in better understanding of chronic escitalopram treatment. The present study provides insight the neurobiology of MSA, identify prognostic markers and design into the molecular mechanisms underlying the beneficial effects neuromodulatory treatment. of antidepressant treatment in alleviating chronic stress-induced depressive-like behavior and cognitive deficits. 30. Role of enriched environment and antidepressants treatment on chronic stress-induced cognitive deficits. Ms. Shilpa BM. Guides: Dr. BS Shankaranarayana Rao (Funding by CSIR-SRF)
Affective disorders like stress, anxiety and depression are highly concomitant with high prevalence worldwide. Antidepressants are the first line therapy to treat these disorders. Among many antidepressants, the selective serotonin reuptake inhibitor (SSRI), escitalopram is known to facilitate learning and memory and the mechanisms underlying cognitive effects remain to be elucidated. Accordingly, the present study was designed to examine the role of Escitalopram treatment restored BDNF expression in the hippocampus and chronic escitalopram treatment on alleviating depression-induced amygdalar complex of stressed rats. Bottom panel shows representative immunoblots of BDNF and β-actin from different groups of animals. Upper cognitive deficits and altered expression of neurotropic factors. panel shows the differential expression of BDNF in hippocampus and Chronic immobilization stress induced behavioural depression and amygdalar complex with respect to chronic stress and escitalopram treatment. Data expressed as Mean ± SEM. NC: Normal control; ST: Animals subjected exhibited reduced exploratory behaviour with enhanced anxiety in to ten days of chronic immobilisation stress (CIS); ST + ES-5 and ST + ES-10: the open field and elevated plus maze tests, respectively. Spatial CIS rats treated with 5mg or 10 mg/kg body weight intraperitoneally for 14 learning and memory impairment was completely ameliorated by days; ST + VC: CIS followed by 14 days of vehicle injection. One-way ANOVA followed by Tukey’s post hoc test, *p<0.01; **p<0.01 vs. NC. ###p<0.001 vs. ST. escitalopram treatment for 14 days in stressed rats. Values were normalized to β-Actin and compared with normal controls. Each group consisted of 5 rats.
31. Role of enriched environment and antiepileptic drugs on epilepsy-induced cognitive deficits. Ms. Vrinda M. Guides: Dr. BS Shankaranarayana Rao, Dr. Bindu M Kutty (Funding by CSIR-SRF)
Temporal lobe epilepsy (TLE) is a common and intractable form of focal epilepsy. Spontaneous recurrent seizures (SRS) are the hallmarks of TLE and are often associated with depression and cognitive impairments. The mechanisms of generation of SRS, epileptogenesis and associated depression and cognitive deficits are yet to be understood. Accordingly, the investigators have used the Chronic escitalopram treatment ameliorated spatial learning and memory impairment in stressed rats. (a) Stressed rats treated with escitalopram lithium-pilocarpine model of TLE to assess the seizure characteristics, (5, 10 mg/kg, b.w intraperitoneally) for 14 days show complete recovery of spatial learning, memory and depressive-like behaviour. The role spatial learning and memory. Chronic stress-induced learning impairment in of antiepileptic drug levetiracetam (LEV) treatment, exposure to the last two blocks is completely reversed after escitalopram treatment. Data expressed as Mean ± SEM. NC: Normal control; ST: Animals subjected to ten enriched environment (EE) and the combination of EE and LEV for days of chronic immobilisation stress (CIS); ST + ES-5 and ST + ES-10: CIS rats 14 days on TLE-induced deficits were also evaluated. Epileptic rats treated with 5mg or 10 mg/kg body weight intraperitoneally for 14 days; ST + VC: CIS followed by 14 days of vehicle injection. One-way ANOVA followed were video-monitored using phenotyper to behaviorally characterize by Tukey’s post hoc test, *p<0.01; **p<0.01, ***p<0.001 vs. NC; ##p<0.01, seizure frequency and duration followed by analysis of EEG from ###p<0.001 vs. ST; $ p<0.05 vs. ST + ES-10.
National Institute of Mental Health and Neuro Sciences 189 Annual Report 2015-2016 the hippocampus, somatosensory and parietal cortices. Subsequently these epileptic rats were assessed for depressive-like behaviour using sucrose preference test and spatial learning and memory in Morris water maze. TLE was associated with increased SRS, altered EEG power, depression-like behaviour and cognitive deficits. Interestingly, EE, LEV and combination therapy reduced SRS in TLE rats (Fig 1A & B). Depression-like behaviour (anhedonia) was alleviated by EE and combination therapy (Fig 1C), whereas, LEV exacerbated this behaviour. Spatial learning and memory deficits in TLE was ameliorated by LEV and combination therapy (Fig 2A-D), whereas, EE alone did not reverse it. Additionally combination therapy restored delta and beta 1 power in in the somatosensory cortex of epileptic rats (Fig 3A & B). The synergistic action of EE and LEV might provide a novel treatment option for recurrent and drug-resistant epilepsies.
Combination treatment of Levetiracetam and enriched environment exposure ameliorated temporal lobe epilepsy induced spatial learning and memory impairment in the Morriswater maze task. Epileptic rats showed spatial learning deficit by exhibiting increased latency to reach platform (A), enhanced mean distance from platform (B) in acquisition phase of the task,enhanced mean distance from platform (C) and decreased chance ratio (D) in the probe trial of the task. Combination therapy showed restoration of spatial learning and memory by exhibiting improvement in the above mentioned task. Data expressed as Mean ± SEM. Control: Control: Normal control; EP: Epilepsy eight weeks post SE; EP + EE: Epilepsy 6 weeks post SE followed by 6h/day of enriched environment exposure for 14 days; EP + Lev: Epilepsy 6 weeks post SE followed by treatment with levetiracetam for 14 days; EP + EE + Lev: Epilepsy 6 weeks post SE followed by 6h/day of enriched environment exposure and treatment with levetiracetam for 14 days. Data was analyzed by Two-way ANOVA followed by Bonferroni post-hoc test. Each group consisted of 14 to 22 rats. **p<0.01, ***p<0.001 vs. Control; ##p<0.01, ###p<0.001 vs. EP.
Levetiracetam in combination with enriched environment attenuates seizure episodes, seizure duration and behavioural depression in temporal lobe epilepsy. Chronic treatment with levetiracetam and enriched environment Combination treatment of Levetiracetam and enriched environment exposure reduced seizure episodes (A) and total seizure duration (B) enhanced sucrose improved delta and beta 1 power in the somatosensory cortex of epileptic consumptionin the epileptic animals (C).The relative change represents the rats. Epileptic rats exhibited decreased delta (A) and beta 1 (B) power in the difference between pre and post treatment. Data expressed as Mean ± SEM. left and right somatosensory cortex. Enriched environment and levetiracetam Control: Normal control; EP: Epilepsy eight weeks post SE; EP + EE: Epilepsy intervention combinedly restored delta and beta 1 power to normal in epileptic 6 weeks post SE followed by 6h/day of enriched environment exposure rats. Percentage difference between day 28 and d45 was calculated and data for 14 days; EP + Lev: Epilepsy 6 weeks post SE followed by treatment with was log transformed. Data expressed as Mean ± SEM Control: Normal control; levetiracetam for 14 days; EP + EE + Lev: Epilepsy 6 weeks post SE followed by EP: Epilepsy eight weeks post SE; EP + EE: Epilepsy 6 weeks post SE followed 6h/day of enriched environment exposure and treatment with levetiracetam by 6h/day of enriched environment exposure for 14 days; EP + Lev: Epilepsy 6 for 14 days. Data was analyzed by Student’s t-test for seizure behaviour and weeks post SE followed by treatment with levetiracetam for 14 days; EP + EE One-way ANOVA followed by Tukey’s multiple comparisons post-hoc test for + Lev: Epilepsy 6 weeks post SE followed by 6h/day of enriched environment sucrose preference test. Each group consisted of 07 to 30 rats. **p<0.01 vs. exposure and treatment with levetiracetam for 14 days. Data was analyzed by Control; ##p<0.01, ###p<0.001 vs. EP. One-way ANOVA followed by permutation based t test. Each group consisted of 06 to 09 rats. *p<0.05 vs. Control; #p<0.05, ###p<0.001 vs. EP.
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32. Role of amygdala in stress-induced cortical plasticity. Mr. The temporary inactivation of basolateral amygdala prevents the stress- Sunil Jamuna Tripathi. Guides: Dr. BS Shankaranarayana induced microgliosis. NC = Normal control (n = 06), ST = Stress (n = 06), LI+ Rao, Dr. TR Raju (Funding by CSIR-SRF) ST = Lidocaine + Stress (n = 06), VC (SAL) + ST = Vehicle + Stress (n = 06), SC (LI) = Sham control (n = 06), LI per se = Lidocaine per se (n = 06) and VC (SAL) per se = Vehicle per se (n = 06). (B) Representative images of normal control, Repeated stress is associated with aberrant glial morphology. The stress and permanent inactivation of BLA stained with Iba-1. The permanent inactivation of basolateral amygdala prevents the stress-induced enhanced anomalous glial responses following stress are manifested as depression microglial expression. NC = Normal control (n = 06), ST = Stress (n = 06), IBO and associated disorders. The basolateral amygdala (BLA) exerts + ST = ibotenic acid + stress (n = 06), VC (PBS) + ST = Vehicle + stress (n = 06), a positive regulation of the HPA axis and undergoes hypertrophy SC (IBO) = Sham control (n = 06), IBO per se = Ibotenate lesion per se (n = 06) and VC (PBS) per se = Vehicle per se (n = 06). One-way ANOVA followed following stress. It is not known if the BLA hyperactivity is responsible by Tukey’s test. Data expressed as Mean ± SEM.**p<0.01,***p<0.001 vs. NC; ### for the stress-induced gliosis in the prefrontal cortex (PFC). Accordingly, p<0.001 vs. ST. the investigators evaluated if temporary or permanent inactivation of BLA could prevent the stress-induced aberrant glial morphology in the 33. Depression-induced cognitive deficits: effect of modulation PFC. The chronic stress leads to microgliosis in the prelimbic cortex. of glutamatergic transmission and brain stimulation The inactivation of BLA during stress prevented the microgliosis in reward. Ms. Suwarna Chakraborty. Guides: Dr. BS the prelimbic cortex. These results indicate that the BLA plays an Shankaranarayana Rao. Guides: Dr. TR Raju (Institute important regulatory role in the stress-induced deleterious effects on funding) the microglial structure and function in the PFC. Depression is a multifactorial disease characterized by impaired A. Effect of temporary inactivation of BLA on stress-induced cognitive functions due to altered glutamatergic homeostasis, microgliosis declined levels of neurotransmitters and anomalous synaptic plasticity. Current pharmacotherapies have a slower onset of action and a higher recurrence rate. Therefore, there has been recent interest in glutamatergic modulators such as N-acetyl- cysteine. Accordingly, the effect of N-acetyl-cysteine on learning and memory in the neonatal clomipramine model of endogenous depression was investigated. The chronic treatment with N-acetyl- cysteine restores the depression-induced behavioral despair, anhedonia and enhanced anxiety-like behavior. Interestingly, the depression-induced spatial learning deficits were also reversed by N-acetyl-cysteine treatment. It was demonstrated that chronic N-acetyl-cysteine treatment effectively ameliorates depression- induced cognitive deficits.
A. Learning B. Effect of permanent inactivation of BLA on stress-induced B. Acquisition ofRewarded Alternation Task in T-Maze microgliosis C. Retention of Rewarded Alternation Task in T-Maze
Chronic stress-induced microgliosis in the prelimbic cortex were prevented temporary and permanent inactivation of BLA (A) Representative images of normal control, stress and temporary inactivation of BLA stained with Iba-1.
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and exposure to enriched environment improved the spatial memory deficits in cue based Morris water maze (MWM) and diminished the depressive-like behaviour in sucrose preference test (SPT) as well as forced swim test (FST). It is not understood how levetiracetam or enriched environment affect these behavioural changes. Accordingly, in the current study, changes in hippocampal neurogenesis, short- term and long-term synaptic plasticity and levels of neurotransmitters that underlie the behavioral improvement will be evaluated.
35. Modulation of glutamatergic transmission in epileptogenesis and epilepsy-induced cognitive deficits. Mr. Anirudh R Acharya. Guides: Dr. BS Shankaranarayana Rao, Dr. BN Srikumar, Dr. Bindu M Kutty (Funding by UGC)
Epilepsy is a neurological disorder characterized by hyper-excitable neuronal networks which causes spontaneous recurrent seizures. This hyper-excitation is mediated by principal excitatory neurotransmitter in the brain, glutamate. Previous studies have shown that changes in the glutamate transmission occur during the development of epileptic network known as ‘epileptogenesis’. So the present study aims to understand if modulating glutamate transmission during epileptogenesis can prevent development of epilepsy. Transmission of glutamate has also been an important pharmacological target for designing anti-epileptic drugs. However, their effects on cognitive Chronic treatment with N-acetyl-cysteine (NAC) restores the depression- induced spatial learning deficits in an endogenous model of depression. (A) functioning during epilepsy have not been addressed. Accordingly, The rate of acquisition of task was significantly slower in depressed animals the study also aims to understand the effect of modulating glutamate compared to controls. Chronic treatment with NAC restored the depression- induced impaired perfromance in rewarded alternation task in T-maze. transmission on cognition by assessing structural, electrophysiological, (B) NAC treatment reverses the depression-induced spatial learning and biochemical and behavioral parameters. memory deficits during acquisition of rewarded alternation task in T-Maze. (C) Chronic NAC treatment also reverses the depression-induced impaired spatial learning during retention of rewarded alternation task in T-Maze.Data 36. Impact of early life stress on the behavioral, * ** *** expressed as Mean±SEM, p<0.05, p<0.01, p<0.001 vs. Normal Control; electrophysiological and epigenetic factors in rats. Mr. #p<0.05, ##p<0.01, ###p<0.001 vs. Depressed. Two-way ANOVA followed by Bonferroni’s post hoc test; One-way ANOVA followed by Tukey’s post hoc test. Pradeep Kumar Mishra. Dr. Laxmi T Rao, Dr. Bindu M Kutty (Funding by CSIR, New Delhi and ICMR, New Delhi 34. Cellular and molecular basis of temporal lobe epilepsy- induced cognitive deficits: role of enriched environment and The present study showed long-term impact of 10 days of maternal levetiracetam treatment. Mr. Raghava Jagadeesha Salaka. separation and isolation stress (MS) during SHRP on the fear memory Guides: Dr. BS Shankaranarayana Rao, Dr. BN Srikumar, and fear extinction in male Wistar rats. Fear acquisition, retention, Dr. Bindu M Kutty (Funding by ICMR) extinction and extinction recall protocols were performed in 5 week, 8 week, 15 week and 1-year-old rats. Simultaneously spike recording Epilepsy is the fourth most common disorder affecting more than and nuclear staining (HDAC- Histone deacetylase enzyme) from 50 million people worldwide. Despite significant improvement infralimbic cortex (ILC) and paraventricular nucleus of hypothalamus in pharmacotherapy of epilepsy, none of the currently available (PVN) was done in both MS and NMS rats. Results showed increase antiepileptic drugs alleviate all the symptoms of the disease and in fear memory with impaired fear extinction recall in 8-week-old MS are associated with adverse effects. Further, development of drug rats as compared to age matched controls. Electrophysiology results resistance and cognitive dysfunction as a consequence of either the showed reduced tone specific spike activity in ILC whereas enhanced disorder itself or the treatment continue to pose challenges. The tone specific spike activity in PVN neurons during fear retention and pharmaco-resistant patients may be prone to comorbid conditions extinction recall in MS rats. These changes were supported by elevation like anxiety, depression and sleep disorders. A previous study in baseline expression of HDAC2 (PVN and ILC) in MS rats. This from the laboratory has shown impairment in spatial learning and showed that any insult during SHRP affects cognitive functions and depression-like behaviour in the lithium-pilocarpine model during emotional maturation which could persist later in life and finally the spontaneous recurrent seizure phase. Levetiracetam treatment enhance the risk of depression, PTSD and generalized anxiety.
192 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
37. Prenatal valproic acid exposure in rats: The neural mechanism 38. The role of constraint induced movement therapy (CIMT) in of changes in attention. Ms. Kumari Anshu. Guides: Dr. cortical plasticity in animal model of intracortical ischemic Laxmi T Rao, Dr. Shoba Srinath (Funding by UGC, New stroke. Ms. Nesin Mathew, Dr. Laxmi T Rao, Dr. Anupam Delhi) Gupta (Funding by UGC)
Autism is a childhood developmental disorder. Apart from the core Stroke is the leading cause of adult disability and rehabilitation is the features of autism, attention deficits are also reported in human only method to regain the lost functional connectivity. Constraint studies, but are relatively unexplored in animal models of autism. Induced Movement Therapy (CIMT) is identified to be well effective The investigators are studying different dimensions of attention in a in regaining the functional activity of paretic upper arm even in prenatally induced Valproic acid (VPA) rat model of autism. chronic stroke cases.
VPA male rats showed impaired passive attention (versus controls) The study shows functional recovery of forearm after CIMT in as they exhibited PPI deficits under different pre-pulse intensities Endothelin-1 induced rat model of ischemic stroke. CIMT played and inter-stimulus intervals. VPA rats (both sexes) had poor active an important role in ameliorating ischemic stroke induced abnormal sustained attention as they took more sessions to reach target criteria movement in reach to grasp task along with a profound improvement in 5-CSRTT task as compared to controls because of significantly in performance. increased omissions.
Pre-pulse Inhibition under different pre-pulse intensity and inter-stimulus intervals. VPA male rats showed significant impairments in pre-pulse inhibition as compared to SAL male rats. Data expressed as mean ± SEM. n= 14 VPA (male) rats, 14 VPA(female) rats, 14 SAL (male) rats and 14 SAL( female) rats. Garcia Score for evaluation of Neurological Deficit after Ischemic stroke. Two-way ANOVA followed by Bonferroni correction (***p<0.001; **p<0.01; NC (n=4), VC (n=4), ISC (n=15). One way ANOVA followed by Newmann - *p<0.05). Keuls Multiple comparison post test showed significant difference in the Garcia score for Neurological deficit after ischemic stroke in ISC group when compared to NC and VC (F= 12.32, p<0.05 )
Reach to grasp task - Percentage of success NC (n=9), NC+CIMT (n=4), Number of sessions taken to reach the target criteria (≥ 80% Response VC+CIMT (n=3), ISC (n=17), ISC+CIMT (n=11). Two-way ANOVA followed Accuracy and < 20% omissions). Both male and female VPA rats took more by Bonferroni post tests has shown significant reduction in percentage of sessions to reach target criteriaas compared to SAL rats. Data expressed reach success in ISC and ISC+CIMT group on d5. ISC+CIMT group has shown as mean ± SEM. n= 9 VPA (male) rats, 9 VPA(female) rats, 6 SAL (male) rats a significant improvement in percentage of reach success compared to ISC and 3 SAL( female) rats. Two-way ANOVA followed by Bonferroni correction group on d17 (F= 12.58 *P<0.05, *** P<0.001 in comparison with NC; $$ (***p<0.001 between males, $$$p<0.001 between females). P<0.01, $$$ P<0.001 in comparison with ISC group).
National Institute of Mental Health and Neuro Sciences 193 Annual Report 2015-2016
Recent Fear Memory assessment in Classical Fear conditioning task. The amount of freezing was a index of fear during task. NMS=12; MS=7. MS rats showed increased fear memory. Student’s test was used to assess Statistical significance. Data is presented as Mean+_ SEM (p<0.05).
Rat motor cortex on Day17 after ischemic insult
39. Early maternal separation stress induced anxiety and its relation to anterior cingulate cortex functions in processing emotional tasks. Mr. Maltesh Kambali. Guides: Dr. Laxmi T Rao, Dr. Ravi Muddashetty (Funding by NIMHANS)
Considerable evidences suggest that any insults such as maternal Remote Fear Memory assessment in Classical Fear conditioning task. The separation stress, isolation stress, environmental stress (exposure to amount of freezing was a index of fear during task. NMS=14; MS=8. Both the an endotoxin1), during early developmental period, have significant group of rats showed increased remote fear memory. Student’s test was used to assess Statistical significance. Data is presented as Mean+_ SEM (p<0.05). effect on normal physiological development of brain and increases vulnerability to psychopathology in adult life. 40. Prenatal exposure of Valproic Acid in rats: Effect on sleep architecture. Dr. UD Kumaresan. Guide: Dr. Laxmi T Rao This early life stress precipitates into a permanently altered anxiety- (Funding by NIMHANS, Bengaluru) like behaviour associated with changes in emotional and cognitive capacities in adulthood. A candidate brain region involved in both Environmental and genetic factors play an important role in autism cognitive and emotional behaviour such as anterior cingulate cortex, and altering the sleep physiology. The present study investigated how its function is altered not yet well know. Therefore, in the present polysomnography sleep measures after 2 months of post-natal life in study, the investigators are going to access neural activity, behaviour and Valproic acid (VPA) induced animal model of autism. The study provides molecular marker expression in anterior cingulate cortex at adulthood evidence for disrupted sleep patterns in VPA rats relative to NC rats. in the animals subjected to early life maternal separation stress. Total sleep duration was significantly higher in VPA rats compared to NC rats. Both VPA and SAL rats had more REM sleep while showing Comparison between normal rats (NMS) and maternal separation no major changes in anxiety and social behaviour. Similarly, VPA rats stress rats (MS): provided inconsistent data showing unaltered pre-pulse inhibition; rather, they showed pre-pulse facilitation for some stimulus parameters.
The effect of Valproate (VPA) on sleep-wake cycle in rats. NC: Normal control, Test for anxiety behavior in light Dark chamber. Three parameters measured VPA: Valproate exposed group, SAL: Saline treated group.Data expressed as as index of anxiety. NMS=18; MS=24. MS rats showed increased anxiety. mean±SEM. n= 5 NC rats, n=4 VPA rats and n=2 SAL rats. Repeated measures Student’s test was used to assess Statistical significance. Data is presented as of Two-way ANOVA followed by Bonferroni correction tests. (** p<0.01, $$$ Mean+_ SEM (p<0.01). p<0.001)
194 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
41. A study on the mechanisms of action of Chitotriosidase-1 – relevance to pathophysiology of sporadic ALS. Ms. Rashmi Savant. Guides: Dr. Vijayalakshmi K, Dr. TN Sathyaprabha (Funding by UGC-JRF)
In view of the significantly higher levels of Chitotriosidase-1 (CHIT- 1) found in ALS-CSF and its neuroinflammatory role observed in the microglial cultures, the present study aims at investigating the molecular pathways that are activated by CHIT-1. The role played by CHIT-1 in immunomodulation will also be investigated by live cell imaging of the microglial cultures exposed to recombinant Chit protein. Additionally, the study aims at identifying the probable factors present in ALS-CSF which may trigger the synthesis of CHIT-1. Intensity of cellular TH expression in SNpc by densitometry was comparable between parent strains & F1X1, whereas it was significantly higher in F1X2, which was higher even when compared to CD-1 and F1X1. Immunoblotting 42. Ontogenesis of nigral dopaminergic neurons and also revealed concomitant results. Interestingly, other strains showed a trend electrophysiological assessment of substantia nigra of of higher TH expression after MPTP treatment. crossbreds of two mice strains with differential susceptibility to 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine (MPTP). Mr. Vidyadhara DJ. Guides: Dr. Phalguni Anand Alladi, Dr. TR Raju
The findings of the study on higher basal numbers and relatively attenuated death of dopaminergic (DA) neurons in neurotoxic conditions in CD-1 mice provide anatomical evidence for its resistance to MPTP. The crossbreds are even better protected against MPTP, which is reflected as supernumerary nigral neurons, absence of neuronal death and unaltered tyrosine hydroxylase (TH) expression. A similarity in anatomical substrates and molecular mechanisms of TH expression in the dorsal striatum as determined by IHC revealed mildly higher expression (6-8%, non-significant) in CD-1 and crossbreds compared to neuroprotection may be envisaged in the Anglo-Indians, who have that of C57BL/6. MPTP administration significantly reduced the TH expression much lower occurrence of PD. This animal model of admixture in C57BL/6, whereas expression was preserved in CD-1 & crossbreds. Volume estimation revealed smaller striatum in C57BL/6 compared to CD-1 and the provides an interesting experimental paradigm to study the molecular crossbreds, with no affect after MPTP administration. mechanisms pertinent to the human phenomenon of differential PD prevalence. 43. Assessment of developmental apoptosis and Mitochondrial responses in F1 crossbreds of Two Mice strains with differential sensitivity to 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydro-Pyridine. Mr. H Yarreiphang. Guides: Dr. Phalguni Anand Alladi, Dr. TR Raju, Dr. BK Chandrasekhar Sagar
Susceptibility of MPTP neurotoxin amongst different mice strains is observed to be variable. In this study, the resistant mouse CD1 is shown to express lesser apoptotic markers proteins such as Bax, Bcl2, their ratio and caspase-3 compared to susceptible C57Bl/6. The duration of developmental apoptosis appeared to continue even at postnatal 22 in C57BL/6 and significantly higher than CD1 or their crossbreds. Apoptosis inducing factor is up-regulated in the susceptible strain post MPTP-treatment. The higher expression of No. of DA neurons in SNpc were significantly higher in CD-1 and in both the crossbreds, compared to C57BL/6. After MPTP, the DA neuronal death in apoptotic proteins and extended developmental apoptosis which lead C57BL/6 was significantly high when compared to normal, whereas itwas to lesser DAergic neuron could be one of the reasons for MTPT only 10-15% in CD-1 mice. Interestingly, both the crossbreds did not reveal any neuronal death. SNpc volume also showed similar trends. susceptibility in C57BL/6.
National Institute of Mental Health and Neuro Sciences 195 Annual Report 2015-2016
44. The role of glia in aging and in determining the differential susceptibility of two mice strains to 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP). Mr. Abhilash PL. Guides: Dr. Phalguni Anand Alladi, Dr. Bindu M Kutty
Calbindin immunopositive cells in mice substantia nigra
High Caspase-3 and AIF levels in C57BL/6 during development compared to resistant CD1 or their crossbred (F1X1 and F1X2). There is no difference at adulthood. High level of AIF expression in C57BL/6 and lesser in F1X1 at P14 seem to play a significant role during developmental apoptosis period.
Ratio of Bax:Bcl2 is significantly high in C57BL/6 during development and at adulthood.
Calbindin expression was identified in the band of substantia nigra pars compacta in both C57BL/6 and CD-1 mice (Figure 1A&B). Higher magnification images showed that the labelling was primarily in the perinuclear region of the nigral neurons of C57BL/6 mice as their cytoplasm was scantily stained, The level AIF expression were higher in C57Bl/6 and CD1 mice and low and contrarily, the neurons of CD-1 mice showed a pan-cytoplasmic staining in F1X1 and F1X2 mice. MPTP exposure causes significant upregulation of (Figure 1, compare C&D). E) Stereological estimation revealed significantly AIF in C57BL/6 and FIX2 but not in CD 1 and F1X1. Caspase-3 expression was higher number of calbindin IR cells in the SNpc of the CD-1 strain compared unchanged in the pure strains (C57BL/6 and CD1) upon MPTP injection, while to that of the C57BL/6 mice (35%; Fig. 1E; C57BL/6: 6160 ± 239.3 vs CD-1: it was significantly downregulated in the crossbreds (F1X1 and F1X1). Lower 8329 ± 192.2, p<0.001). (F)Immunofluoresence image of Calbindin positive level of Caspase-3 expression in the crossbreds might be an indication of a cells in SNpc better protection against toxin.
TUNEL (terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling) A) Representative image of Iba-1 positive (black coloured) microglial cells and assay revealed a higher apoptotic DAergic neuron in the midbrain SNpc of TH positive dopaminergic neurons (brown) in substantia nigra pars compacta F1X1 and CD1 at P14. Highest apoptosis was observed in C57BL/6 at P14, B) Stereological estimation revealed significantly higher number of Iba-1 which could be a plausible explanation for fewer DAergic neuron numbers in positive cells in the SNpc of the C57BL/6 mice compared to that of the CD-1 the adult C57BL/6. mice.
196 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
The aim of the study is to investigate the role of glia in aging and a higher frequency of deletions. The FISH study can be used to predict in determining the differential susceptibility of two mice strains the behavior of meningiomas if significant association is found. (C57bl/6 and CD1white) to MPTP by using the techniques of immunohistochemistry, stereology, confocal microscopy, ELISA/ 2. Identification of traumatic brain injury (TBI) biomarker Western blotting. Stereological quantification showed more basal using proteomics. Investigators: Prof. Indira Devi B, Dr. number of calbindin-d28k immunoreactive nigral neurons in CD1 Dhananjaya Bhat, Dr. Nishanth Sadashiva (Funding by mice (MPTP Resistant) than the C57BL/6 mice. The investigators DBT) further demonstrate that the CD1 mice have fewer Iba-1 cells compared to that of C57BL/6 (MPTP susceptible), which suggest 3. Randomized evaluation of surgery with craniectomy that non-neural cell also play a critical role in determining differential for patients undergoing evacuation of acute subdural susceptibility to MPTP. haematoma (RESCUE-ASDH). Investigators: Prof. Indira Devi B, Dr. Dhananjaya Bhat, Dr. Nishanth Sadashiva, 45. A study of circulating biomarkers in Parkinson’s disease with Prof. Sampath S, Dr. Prabhuraj AR (Funding by Cambridge dementia. Ms. Aditi Naskar. Guides: Dr. Phalguni Anand University Hospitals NHS Foundation Trust and University Alladi, Dr. Pramod Pal, Dr. Shantala Hegde, Dr. Jitender of Cambridge) Saini (Funding by ICMR) 4. Genetic, epigenetic and biochemical profile of lumbar It is extensively debated whether Parkinson’s disease with Dementia disc degeneration in Indian population. Investigators: Dr. (PDD) and Parkinson’s disease (PD) are distinct disorders or whether Dhananjaya I Bhat, Dr. Dhaval P Sukla, Dr. Chetan GK they represent different presentations of the same disease. There are (Funding by SERB, DST, India) no preclinical methods to determine which of the patients with mild cognitive impairment (MCI) will progress into PDD. Therefore, the Low back pain is the most common cause of disability and LDD study intends to identify the CSF biomarkers, if any. The levels of four is widely believed to be one of the major contributing factors. main biomarkers such as α- synuclein, total tau, phosphorylated tau Identification of gene association may provide insight into the and Aβ42 and their co-relation will also investigated to distinguish etiology and patho-physiology of this disease which in turn may between the two entities. provide information regarding prevention and management. The investigators propose to identify the genetic variation and the biomarkers of LDD. The plan is to analyse the SNPs of relevant Neurosurgery genes in LDD, so as to predict the risk of LDD. The gene polymorphisms which are already attempted in other population 1. Chromosomal aberrations in atypical and anaplastic and having relevance with degenerative disc diseases are selected for meningiomas: Prognostic implications. Investigators: Dr. this present study. The biochemical profiling of the LDD helps in Dwarakanath Srinivas, Dr. Vani Santosh, Dr. Sampath S the biomarker discovery which is easy to apply in a clinical setup (Funding by DST) to classify different patient groups. The analysis of the disc tissue for gene methylation and gene expression of SPARC gene would There is significant variability in the biologic behavior of meningiomas, lead to the discovery of the therapeutic targets in LDD. LDD is especially of atypical and anaplastic meningiomas. The investigators a common problem in India, which affects the normal activity of analyzed deletions in regions 22q, 18p11, 1p32, and 14q32 in grade young population. Addressing this serious issue systematically will II and grade III meningiomas and their correlation with tumor help in novel diagnosis and treatment which may reduce the burden grade and recurrence. A total of 59 samples of grade II and grade III of the disease in the population. meningiomas were analyzed with fluorescence in situ hybridization (FISH) technique with locus specific probes. There was a statistically 5. Atypical and anaplastic meningiomas: Prognostic significant increase in deletions in recurrences when compared to implications of clinicopathological features. Investigators: primary surgeries. The mean mitotic index was higher in patients Dr. Dwarakanath Srinivas, Dr. Vani Santosh (Funding by with deletions. Patients with 18p deletions tended to be younger DST) and had a significant association with sheeting. 22q deletions were associated with hypercellular tumors. 1p, 14q, and 1p14q codeletion 6. Glioma serum biomarker discovery through proteomic had a significant association with mitosis ≥7. This is the first study approaches. Investigator: Dr. Arivazhagan A (Funding by from India analyzing all these four sites for deletions using the FISH DBT, New Delhi) (Multi institutional Project between technique. Recurrent tumors and tumors with tendency to recur have NIMHANS and IISc, Bangalore)
National Institute of Mental Health and Neuro Sciences 197 Annual Report 2015-2016
The study has identified novel proteins by LC MS/MS techniques cortex. T1-hyperintensity was noted in 19.5% (n=8) patients. which are differentially expressed in sera of GBM patients when Whenever, EcoG (n=24) is used during surgery, it affects and assists compared to control samples. We have identified a novel cytokine extension of resection in 83.33% (n=20). Invasive monitoring was signature for identification of glioma by serum technique, which has needed for defining the EZ in17.85% (n=5) of prospective patients. been publisjed. Also, the role of MCSF in glioma has been studied in Most common extra-temporal location for dysplasia was found to detail and is published. be frontal lobe (19.5%). Overall outcome of Engel’s class Ia among all patients was 63.4 %. Complete resection (p < 0.001), temporal 7. Biochemical and histological analysis of traumatic brain location (p = 0.02) and Type I FCD were positive prognostic injury in neurotrauma patients. Investigator: Dr. Nupur indicators of seizure-free outcome in this series. Pruthi (Funding by ICMR) 12. Molecular stratification of pediatric infratentorial 8. Development of artificial intelligence tool utilizing ependymomas. Dr. Nagarjun MN. Guides: Dr. Sampath clinical neurological examination for clinical diagnosis S, Dr. Arivazhagan A, Dr. Vani Santosh (Funding by in neurosurgical patients. Investigators: Dr. Vikas V, Dr. Neurosurgery research fund, NIMHANS) Sampath S, Dr. Narsing Rao, Ms. Sindhu MG (Funding by DST) Molecular profiling of 40 cases of paediatric posterior fossa ependymomas was carried out and prognostic biomarkers were The project aims to mimic physician logic using artificial intelligence identified. Expression of EGFR and presence of true rosettes were techniques to evolve software packages for the diagnosis of associated with reduced recurrence free survival, whilst CBX 7 neurosurgical diseases. Emphasis is on the arrival at diagnosis from expression was associated with longer recurrence free survival in objective clinical findings, which are re-producible. anaplastic tumors. Established biomarkers such as YKL 40, NELL, LAMA did not show association with survival in this cohort. 9. Effect of pentoxyphylline on microvascular flow pattern in experimental cerebral vasospasm model. Investigator: Dr. 13. Quality of life and cognitive outcome in long term survivors Prabhuraj AR (Funding by NIMHANS) of glioblastoma. Dr. Chirag Solanki. Guides: Dr. Sampath S, Dr. Arivazhagan A, Dr. Vani Santosh 10. International surgical outcome study (ISOS). Investigator: Dr. Prabhuraj AR The incidence of long term survival, i.e. more than three years, ranges from 3% - 5% in GBM. This study looked at cognitive, psychological 11. Focal cortical dysplasia presenting with chronic drug resistant and social status of survivors. A total of nine patients, who had epilepsy: A study of clinical, electrophysiological, neuro- survived for more than three years, were included in the study. All imaging, neuropsychological, surgical and histopathological the patients were called for quality of life and neuropsychological features: and correlation with the seizure and quality of life. assessment. The quality of life was assessed with WHOQOL- Dr. Jitender Chaturvedi. Guides: Dr. Malla Bhaskar Rao, BREF questionnaire. The neuropsychological assessment was done Dr. Nupur Pruthi, Dr. Sanjib Sinha, Dr. J Saini, Dr. Anita by NIMHANS neuropsychology battery for adults and children Mahadevan and Vineland Social Maturity Scoring Scale (VSMS). The scores were compared with normative data. The quality of life of long term Surgical outcome of 41 patients of DRE with histo-pathologically glioblastoma survivors is affected considerably due to fatigue, poor proven FCD was analyzed. Blumcke et.al 2011 recommended quality of sleep, inability to concentrate, presence of depression, classification system is used for histo-pathological categorization. financial burden and impaired personal and social relationships. EEG, MRI, Magnetoencephalogram (MEG), neuro-psychological Different domains of cognition like motor speed, sustained attention, deficits and QOL utilizing the QOLIE-89 questionnaire were long term memory, mental flexibility and executive functions are carried out for the first time in Indian population. Age of onset of significantly impaired affecting personal, social and professional epilepsy ranged from three months to 40 years (mean 8.83 yrs; SD lives. As the incidence of long term survival is very less, there is 8.30). Duration of epilepsy ranged from 1-39 years (mean 12.02; a need for larger multicentre studies to come-up with definitive SD 9.57). Mean number of AEDs tried over life time dropped results, which in turn can help in formatting the rehabilitative and to mean 2.27(range 0-5; SD 1.35) at-least 2 years after surgery support programs for these patients. (p=0.013) from pre-op score of 6 (range 3-10; SD 1.49). Pre- operative QOLIE-89 score was 26.33-40.17 (mean 33.69, SD 4.35); 14. Comparison of two techniques of handling vessel ends however post-operative score was 59.21-89.79(mean 75.56; SD during micro-vascular anastomoses. Investigator: Dr. Nupur 8.29; p=0.04). 25 patients (60.97%) had dysplasia involving eloquent Pruthi (NIMHANS intramural funding)
198 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
15. Molecular characterization of medulloblastoma and 25. Fibre dissection of cerebellum. Dr. Santhosh Kumar SA. proteomic profiling. Dr. Vinayak Narayan. Guides: Dr. Guide: Dr. Nupur Pruthi Sampath S, Dr. Arivazhagan A, Dr. Vani Santosh (Funding by Neurooncology research fund (0546), NIMHANS) 26. Focal cortical dysplasia: analysis of pre-surgical surgical features, HPE features and surgical outcomes in patients A total of 90 cases of medulloblastoma with known follow-up were with drug resistant epilepsy. Dr. Jitender Chaturvedi. Guides: stratified into molecular subgroups (Wnt, SHH, non-WNT non- Dr. Malla Bhaskar Rao, Dr. Nupur SHH) using the biomarkers; B Catenin, GAB-1. YAP -1 and p53 and the prognostic significance of these subgroups was determined. 27. Molecular alterations in paediatric GBM and their The investigators carried out a pilot study on the proteomic and prognostic significance. Dr. Alok. Guide: Dr. Arivazhagan phosphoproteomic profile of histological and molecular subtypes of Medulloblastoma (MB) and the study identified differential protein 28. Drezotomy in the management of post traumatic brachial expression across various molecular subtypes of MB. In the IHC plexus root avulsion neuropathic pain: fMRI correlates in the validation of the proteomic studies, it was found that the non-WNT/ sensory cortex. Dr. Satyakarm Baruah. Guides: Dr. Indira non-SHH subgroup had the highest GFAP positive tumour cells Devi, Dr. Dhananjaya Bhat, Dr. Dhaval Shukla (51.02 %), followed by SHH (32.6 %) and WNT subgroups (12.2%), the first of its kind in world literature. 29. A study of autonomic dysfunction in brachial plexus injury using qsart: A retrospective study. Dr. Satyakarm Baruah. 16. Cerebral perfusion changes before and after decompressive Guides: Dr. Indira Devi, Dr. Dhananjaya Bhat, Dr. Dhaval craniectomy for cerebral venous thrombosis. Dr. Varun Shukla Reddy. Guides: Dr. S Sampath, Dr. Vikas V 30. Role of diffusion tensor imaging in evaluation of gliomas 17. Comparative prospective study between hinge craniotomy involving eloquent areas of brain. Dr. Kaku Mayur and decompressive craniectomy in the management of Vinaykumar. Guides: Dr. Sampath, Dr. Nupur Pruthi malignant intracranial Hypertension. Dr. Tejesh Mishra. Guides: Dr. B Indira Devi. 31. Effect of Clonidine on paroxysmal sympathetic hyperactivity after traumatic brain injury - A comparative study on 18. Role of DTI in patient with drug resistant epilepsy with outcome. Dr. Manish Joseph Mathew. Guides: Dr. Dhaval focal cortical dysplasia. Prashanth Singh. Guide: Dr. Malla Shukla, Dr. Indira Devi B, Bhaskara Rao 32. Proteome profile of medulloblastoma - Correlation with 19. Can cortical plasticity explain the cause and relief of histology, molecular subtypes and clinical parameters. trigeminal neuralgia: A resting fMRI study. Dr. Mustafa IC. Dr. Vinayaknarayan. Guides: Dr. Sampath S, Dr. Guide: Dr. B Indira Devi Arivazhagan
20. Arterio venous malformation. Dr. Siroya Hardik. Guide: 33. Short-term outcome in patients operated for severe Prof. Malla Bhaskara Rao traumatic brain injury (sTBI) with GCS motor score less than 5. Dr. Anil Jadhav. Guides: Dr. Dhananjaya Bhat, Dr. 21. Genetic study of cervical spondylotic myelopathy. Dr. KVL Narasinga Rao Diptiranjan Satapathy. Guide: Dr. Dhananjay I Bhat 34. Quality of life in patients with Chiari type I malformation 22. Automatic functions in Insular Glioma explorative study. and syringomyelia. Dr. Anil Kumar. Dr. B Indira Devi, Dr. Dr. Ajit Mataprasad. Guide: Dr. Dhaval P Shukla Nupur
23. Variable expression of TIMP-4 Coll IA2 cathespin B, Alpha 35. CT angiogram brain in traumatic brain injury in predicting IAT, bcl-2 and Box genes in intracranial aneurysmal wall. Dr. progression of cerebral contusion. Dr. Nehete Lokesh Gaurav Tyagi. Guide: Dr. Dwarakanath S Suresh. Guides: Dr. B Indira Devi, Dr. Prabhuraj,
24. A study of cognitive profile and quality of life in peditric 36. A retrospective study of surgically treated distal anterior malignant posterior fossa brain tumours. Dr. Ujwal Yeole. cerebral artery aneurysms. Dr. Abhinith Sashidhar. Guide: Guide: Dr. Arivazhagan Dr. Dhaval Shukla
National Institute of Mental Health and Neuro Sciences 199 Annual Report 2015-2016
37. To investigate whether TIVA offers better cerebral protection were further tested for presence of Scrub Tyhpus IgM, Dengue Virus compared to volatile based anaesthesia during intracranial IgM and West Nile Virus IgM using commercially available kits, aneurysm surgeries. Dr. Raghavendra Chalikwar Arun. while the CSF samples were subjected for detection of bacterial/viral Guide: Dr. Dwarakanath S nucleic acids for the following organisms; Stretococcus pneumonia, N. meningitidis, H. influenza, Herpes simplex virus Type 1(HSV), 38. Pediatric brain: white matter volumetry and plasticity Enteroviuses and Chikungunya virus in that order of priority. Out in response to direct versus indirect insult to the brain - of the 1953 patients tested, 371 (19%) were confirmed as JE, 136 Traumatic Brain Injury (TBI) vs Brachial Plexus Injury patients (7%) were probable JE cases and 196 (10%) were positive (BPI). Dr. Kislay Kishore. Guide: Dr. Indira Devi for non-JE etiological agents. Amongst the non-JE AES pathogens, Scrub typhus IgM (6%), Dengue IgM (3%) and West Nile virus 39. A study of outcome in craniovertebral junction pathologies IgM (0.1%) were detected using serum samples while non-JE AES following posterior fusion and screw fixation. Dr. Rajesh pathogens detected in CSF samples by molecular testing included S. Krishna. Guides: Dr. Sampath S, Dr. Dhananjaya Bhat, Dr. pneumoniae (0.6%), H. influenza (0.1%) and HSV (0.2%). Nupur Pruthi 2. Immune signatures of responses to infection with dengue 40. Outcomes of management of large and giant intracranial virus. Investigators: Dr. V Ravi, Dr. Anita Desai (Funding by aneurysms - A 10 years retrospective study. Dr. Jnana Bala DBT-NIH) Parameshwara Rao. Guide: Dr. Dwarakanath S The study is designed to focus on (i) measuring functional immune 41. Study of predicting the ideal free hand posterior ventricular responses of all major arms of the immune system (the innate cells, trajectory using OSIRIX software and the role of occipital T cells and B cells) and their gene expression profiles in response to shape variations. Dr. Harsh Deora. Guides: Dr. Nupur DENV (ii) analysis of specific genetic determinants that have been Pruthi, Dr. KVL Narasinga Rao implicated in defining the outcome of response to DENV infection. During the year, 36 healthy controls and 120 DENV infected patients 42. Role of stemcells in peripheral nerve injury. Dr. Bharath were recruited. Peripheral blood (10ml) was collected during acute Pandit Shinde. Guides: Dr. Dhananjaya Bhat, Dr. Indira infection from all patients and convalescent samples from nine of these Devi after four months. Plasma and Peripheral blood mononuclear cells (PBMCs) were harvested and cryopreserved. Fluorescent antibody 43. Role of decompressive laminectomy in the management panels for immunophenotyping of PBMCs based on HIPC guidelines of poor grade cervical compressive myelopathy. Dr. Sunil were obtained and antibody concentrations for staining were optimized. Malagi. Guide: Dr. Dhaval Shukla Increased number of activated CD8 T cells in dengue fever patients was found, suggesting an active role for CD8 T cells in immune responses to primary DENV infection. In contrast, the investigators found Neurovirology decreased number of naïve T cells in dengue fever patients, which may suggest that the increased number of activated CD8 T cells may be 1. Strengthening surveillance for Japanese encephalitis in dengue specific. Interestingly, elevated proportions of TH1TH17 cells India. Investigators: Dr. V Ravi, Dr. Anita Desai, Dr. Reeta in dengue fever patients were observed. These T cells are reported to be Mani, Dr. Ravi Yadav (Funding by CDC, USA) highly permissive for HIV infection. However, their role in dengue fever is not understood. The investigators also found increased percentages of Acute Encephalitis Syndrome (AES) is a major public health memory B cells in dengue infected patients. The role of these cells in problem in India. Although Japanese encephalitis virus ( JEV) is the primary DENV infection has to be studied. With respect to monocytes major cause of AES identified in India (ranging from 5-35%), no and dendritic cells, it was found that DENV infection resulted in the systematic efforts have been made to determine the precise etiology depletion of myeloid lineage cells such as monocytes and mDCs. of all AES cases. The investigators established a network of 10 testing laboratories within India. In this network, for the first time, 3. Understanding the biology of Chikungunya virus infection an algorithmic approach was undertaken to determine the etiology in permissive cell lines and mosquito vectors. Investigators: of 1253 cases of AES that occurred in four major states affected in Dr. Anita Desai, Dr. Brij Kishor Tyagi, (CRME-ICMR, India- Uttar Pradesh, Assam, West Bengal and Karnataka. A total Madurai), Dr. SN Madhusudana (Funding by DBT) of 1253 AES cases that occurred between January 1st and December 31st 2015 were subjected to an initial screening test for detection of V-ATPase catalytic subunit A protein was identified as a putative JEV ( JEV) IgM antibodies. All JEV IgM negative serum samples protein interacting with CHIKV in C2C12 cells. Anti V-ATPase
200 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 catalytic subunit A antibody was procured commercially for for HIV testing. The National Reference Laboratory, NIMHANS conformational studies. Confirmation of the role of V-ATPase performed quality check of samples tested at the State Reference catalytic subunit A as CHIKV interacting protein on C212 cells Laboratories in Karnataka. A total of 1334 samples were tested for (IFA studies) – antibody dependent infection inhibition assay and cell HIV at the NRL as a part of HSS ANC 2015. surface expression of V-ATPase catalytic subunit A are in progress. Infection inhibition in C2C12 cells upon lipid raft depletion by The National Integrated Biological and Behavioural Surveillance Methyl-β-cyclodextrin (MBCD) to further understand the infection (IBBS) was implemented by NACO among High Risk Groups process is carried out. and migrants to generate evidence on prevalence of HIV and risk behaviours. The NRL-NIMHANS was one of the 16 select To study the virus growth and yield, all three mosquito species laboratories and tested a total of 9431 DBS samples from MSM, Aedes aegypti, Aedes albopictus and Culex quinquefaciatus were given FSW, TG, IDU and migrants for the presence of HIV antibodies. infectious oral blood meal and the infection was analyzed in a time point pattern by IFA, Plaque assay and Q-RT-PCR. Aedes aegypti and Specimens received as a part of HSS 2015 and IBBS at the NRL Aedes albopictus were competent vectors for CHIKV while no infection were also tested for HCV as a part of NACO activity to estimate was detected in Culex quinquefasciatus. As MALDI-TOF data of the prevalence of HCV in the country. The NRL also played a role CHIKV interacting proteins in the mosquito mid-gut (~140kDa) in the quality check of samples tested by the SRLs for HCV. A total upon MASCOT search analysis did not match with any protein in of 13883 specimens (HSS ANC 2015- 4858 samples, IBBS- 9025 the database, the identity of the protein is being further explored. specimens) were tested at the NRL for HCV.
4. National Family Health Survey-4. Investigator: Dr. Anita 6. Role of immune dysregulation in post-partum psychosis. Desai (Funding by International Institute of Population Investigators: Dr. Reeta Mani S, Dr. Manjunatha MV Sciences, Mumbai (NIMHANS Intramural Funding)
The Ministry of Health and Family Welfare, GOI is conducting Post-partum Psychosis (PPP) is the most severe postpartum psychiatric the National Family Health Survey (NFHS-4) in 29 states and six illness with an incidence of 1-2/1000 deliveries with an acute onset union territories aiming to provide estimates of health and family in the first few days or weeks after delivery. The neurobiology and welfare indicators at the state and district level for all 640 districts aetiology of puerperal psychosis remains unclear. Among the in the country. Knowing prevalence of HIV infection in the general biological factors, currently the immune system dysregulation has been population of the country is also one of the key components of the implicated in the manifestation of postpartum psychosis. Therefore, survey The International Institute of Population Sciences (IIPS) under the current research project seeks to understand the role of immune the direction of MoHFW has identified NIMHANS as one of the six system in development of postpartum psychosis. The study proposed laboratories across the country where DBS samples collected from the to perform immuno-phenotyping of peripheral blood mononuclear survey will be tested using internationally acceptable protocols and cell (PBMC) samples and determine the levels of various cytokine guidelines. and chemokine in serum of women with Post-partum Psychosis (PPP) as compared to those with acute psychosis, healthy post- Goa (2 districts), Karnataka (30) and Andhra Pradesh (23) in first partum and healthy non-postpartum women. The cytokines, IL-6 phase while Rajasthan (33), Gujarat (26), Dadra and Nagar Haveli and IL-8 were found to be significantly elevated in the PPP group. and Daman and Diu in phase II are linked to NIMHANS in this Multi-parametric immunophenotyping by flow cytometry revealed survey. The Department of Neurovirology completed testing of significant alterations in subpopulations of T cells, Monocytes, NK 15,123 DBS samples collected under Phase I, of which 1677 were cells, etc. in the PPP group. In addition, the study looks to determine from Goa, 8185 from Karnataka and 5261 from AP. Phase II samples the functional alterations in various cells of the immune system that from Rajasthan (5064) and Gujarat (4784) are being collected and the may contribute to PPP. testing of these phase II samples will be carried out once the estimated numbers of samples are received. 7. Self-sustaining Diagnostic Project (Molecular Diagnostics). Investigators: Dr. Reeta Mani S, Dr. Manjunatha MV 5. Integrated behavior and biological survey. Investigator: Dr. (NIMHANS Intramural Funding) Anita Desai (Funding by NACO, New Delhi) Through this unique self-sustaining service, molecular diagnostic HIV Sentinel Surveillance 2015 is a component of the second tests for 10 different viral and bacterial pathogens are being offered by generation HIV surveillance in India where antenatal clinics are the Department of Neurovirology and Molecular Biology Laboratory, designated as ANC sentinel site where pregnant women were included Neurobiology Research Centre. Several patients from NIMHANS
National Institute of Mental Health and Neuro Sciences 201 Annual Report 2015-2016 have availed these services at concessional rates. Moreover, patients potential to be used as an immunomodulatory drug. from more than 30 other hospitals (both private and public) are utilizing these services on a regular basis. This service model has 12. A comparative study of innate and cell-mediated immune proven to be extremely successful and is now entirely self-sustaining. responses in Human Immunodeficiency Virus infected individuals with and without neurotuberculosis. Ms. 8. Safety and immunogenicity of a recombinant rabies G Deepashri Rao. Guides: Dr. Anita Desai, Dr. V Ravi, Dr. P protein vaccine in healthy volunteers. Investigator: Dr. SN Satish Chandra Madhusudana (Funding by Cadila Pharmaceutical India) Innate and cell mediated immune responses in HIV infected For the first time, Cadila Pharma in collaboration with Novovax, USA individuals with neurotuberculosis were investigated in this study. The has developed a recombinant G protein vaccine against rabies. The hallmark features observed in the immune profile of an HIV infected phase I and II clinical trials were conducted and the blood samples individual with neurotuberculosis compared to other groups were were analyzed for rabies virus neutralizing antibodies by RFFIT. higher frequency of activated T cells, TEM cells, TEMRA cells, higher
Different concentrations and schedules of rabies G protein were immunosenescense in TCM cells and altered cytokine secretion profile evaluated. Currently post exposure studies are being conducted and of T cells to a dysfunctional phenotype. The highlight of this study is samples are being analysed. the potential role of these cell subsets to serve as possible biomarkers in HIV infected subjects with neurotuberculosis, thus enabling better 9. Immunogenicty and safety of a new purified vero cell rabies therapeutic and control strategies in this cohort of individuals. vaccine for post-exposure rabies prophylaxis. Investigator: Dr. SN Madhusudana (Funding by Serum Institute of India, 13. The molecular mechanisms involved in Chikungunya Pune) Virus – Host cell interaction. Investigators. Mr. Ayushman Ghosh. Guides: Dr Anita Desai, Dr. N Gayathri, Dr. SN The serum Institute of India, Pune has developed new purified Madhusudana (Funding by CSIR, DBT) vero cell rabies vaccine using microcarrier technology and affinity chromatography purification. The vaccine was evaluated in phase I This study is designed to investigate key elements in Chikungunya and II trials and phase III trial is ongoing. Sera from patients with virus biology, replication and pathogenesis using a systematic category II and III wounds who were administered the vaccine for approach to identify the cellular components involved in binding and post-exposure prophylaxis were tested for neutralizing antibodies at uptake in cell lines derived from mosquito gut epithelium and mouse various time points post-vaccination. The vaccine was found to be safe myoblasts. Additionally the cytoskeletal changes in mouse myoblast and immunogenic for both intramuscular and intradermal use. cells following Chikungunya virus infection and the role of lipid rafts during virus entry into these cells will also be explored. Given 10. Evaluation of NKT cell based glycolipid adjuvants with rabies the re-emerging threat of CHIKV after 32 years, this study aims to vaccines to improve immunogenicity and long-term protection. illuminate underlying molecular events that determine the outcome of Investigators: Dr. Manjunatha MV, Prof. Madhusudana SN, a CHIKV infection of a host cell, attachment and replication. Dr. Thirumurugaan KG (TANUVAS, Chennai) (Funding by Department of Health Research, ICMR) 14. Neurotropism of Dengue virus serotypes 1-4: an in-vitro comparative study. Investigators: Ms. Amita Kumari Bhagat. 11. Study on molecular aspects of the pandemic Influenza A 2009 Guides: Dr. Anita Desai, Dr. Manjunatha MV (H1N1) virus with special reference to host immune factors. Ms. Maria Thomas. Guides: Dr. V Ravi, Dr. Anita Desai Neurological complications are being increasingly reported among Dengue virus (DENV) infected individuals from around the world, Influenza A (H1N1) in 2009 was the first pandemic of the 21st with considerable evidence for the presence of the virus in the central century. The factors driving the evolution of the virus are not fully nervous system (CNS). Comparing the kinetics of infectivity and understood. The host immune responses may, in some instances, growth of the four DENV serotypes in neural cells and the involvement contribute to immunopathogenesis. Understanding the pathogenic of receptors would help understand the neuropathogenesis of DENV. events leading to severity is important for designing better strategies This information would facilitate selective and improved clinical for prevention and treatment. The investigators found that virus management of dengue cases that are likely to progress towards evolves towards increasing receptor binding affinities and stability developing CNS involvement. Comparative neurotropism among the of the viral HA protein. Novel viral markers of severity of pH1N1, four DENV serotypes in neural cells are being investigated in this the most important being A158E on HA gene were identified. The study. The study also aims to identify and characterize the cellular investigators also found that immunomodualtor mesalamine has the receptor for DENV on neural cell lines.
202 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Nursing 5. Effectiveness of nurses implemented music add- on therapy (NIMAT) in managing children with behavioral problems admitted in Child Psychiatry Ward, NIMHANS, Bengaluru. 1. Strengthening institutional capacity for nursing training Investigators: Dr. G Radhakrishnan, Dr. John Vijay Sagar, on HIV/AIDS in India. Investigator: Dr. Ramachandra Dr. Ramachandra (Funding by NIMHANS) (Funding by GFATM (WHO))
Nurses have great opportunity to spend more time with the children 2. Pattern of technology addiction among undergraduate admitted to the Child Psychiatry Center and with their parents nursing students at college of nursing, NIMHANS (INI) while providing the nursing care. Hence, the researchers believe that Bengaluru, India. Investigators: Dr. Ramachandra, Dr. a module of music prepared in collaboration with child psychiatrists Valliammal Shanmugam and music experts oriented in mental health treatment may be tested for the effectiveness an Add-on –Therapy to bring down The aim of the study is to assess the pattern of technology addiction the behavioral problems of children admitted to Child Psychiatry among undergraduate nursing students at college of nursing, Center. Scientifically proven Ragas will be selected and validated by NIMHANS (INI). It is a quantitative descriptive study conducted the investigators and music expert to prepare a module of an add- at the College of Nursing, NIMHANS among 240 male and female on therapy. This add-on therapy will be implemented by the nurses (1st year to 4th year) B.Sc. nursing students using simple random (with proper training) to reduce the behavioral problems of children sampling technique with the inclusion criteria of using technology admitted to Child Psychiatry Center. in the last one year. Students who were absent at the time of data collection/unwilling to participate were excluded. After obtaining the 6. Effectiveness of Psycho Educational Nursing Program institute ethical clearance, the data was collected using standardized (PENP) on the level of depression among primary caregivers tools including screening questionnaire for internet addiction. Results of inpatients with schizophrenia at NIMHANS, Bengaluru. showed that 250 female undergraduate students acknowledged the Ms. Jiya G Panthanalil. Guides: Dr. Radhakrishnan, Dr. use of video game and internet. 1.3% found to have problematic Venkata Subramanian. status for food, TV and shopping. Video game score was below the cut off value for the sample. Correlation analysis revealed significant The study assessed the effectiveness of a Psycho Educational 0.534 at 0.05 levels in association with items of loneliness. Absence of Nursing Program (PENP) to reduce the level of depression among significant dysfunction score among nursing undergraduate was also primary caregivers of inpatients with schizophrenia (N=32). Results found and 5.2% had problematic use of internet. To conclude, it is the showed that there was a statistically significant (p=0.001) reduction need of the hour to focus on the prevention and rehabilitative aspect in mean scores of depression from pre intervention to immediate of technology addiction in adolescents for a better quality of life. post and follow up assessment stage. The study concluded that caregivers experience depressive symptoms because of patient’s illness. 3. DRISTI (Drive against Stigma). Investigators: Dr. K Hence, early identification through caregiver screening and timely Srinivasan, Dr. Tony Raj, Dr. Sheeja Perumpil, Dr. Maria L intervention can make ample difference. Ekstrand, Dr. Ramachandra (Funding by NIH, collaborative study between St. John’s research Institute (SJRI) and 7. Effectiveness of caregiver driven cognitive activity program University of California, San Fransisco) on selective cognitive functions of patients undergoing ECT at NIMHANS, Bengaluru. Ms. Harshitha. Guides: Dr. K Stigma associated with AIDS has long been recognized as a significant Lalitha, Dr. Chittaranjan Andrade, Dr. Jagadisha T, barrier in the worldwide fight against HIV and AIDS. Among Indian health professionals, ward attendants (WA) and nurses/nursing The study was carried out among the inpatients undergoing a course students, two groups who have the most patient contact, have been of ECT for mental disorder, NIMHANS, Bengaluru (N=21). A found to score most highly on AIDS stigma measures. The study randomized controlled trial double blind design was adopted. The thus aims to develop and test strategies to reduce stigma in these two cognitive activity Program (CAP) of 14 sessions was administered groups to improve the physical and mental health of people living lasting for two hours each day. Analysis revealed statistically significant with HIV/AIDS. (p< 0.001) improvement in selective cognitive functions in the post intervention evaluation between the experimental and control group. 4. A study on the pattern of technology addiction among The study findings support that the CAP was effective in improving undergraduate nursing students at College of Nursing, the selective cognitive functions of subjects who undergo ECT. The NIMHANS, Bengaluru, India. Investigators: Dr. study has significant implications for nursing education, service, Ramachandra, Dr. Valliammal, Dr. Sailaxmi Gandhi, Dr. administration and research. Manoj Sharma
National Institute of Mental Health and Neuro Sciences 203 Annual Report 2015-2016
8. Effectiveness of a structured teaching program on the citizens in selected old age home in Bengaluru. Ms. Nihizh bonding between mothers with mental illness and their Savio MF. Guides: Dr. Ramachandra, Dr. Srikala Bharath infants admitted in mother baby ward, Nimhans, Bengaluru. Ms. Jisha Jose. Guides: Dr. Prasanthi Nattala, Dr. Geetha The present study adopted a pre-experimental one-group, pre-test, Desai post-test design. Art therapy interventions were carried out over 14 days for one hour and post-test was administered on the last day of the The study was carried out among mothers with mental illness admitted intervention, and follow-up on the seventh day following immediate in the Mother Baby Ward, NIMHANS (N=25). Following pre- post-assessment. Analysis revealed statistically significant (p<0.05) assessment, the Structured Teaching Program (STP) was provided to reduction in the mean depression scores at immediate assessment the subjects for 30 minutes for three consecutive days. Post-assessment and follow-up. It was concluded that the art therapy was effective in was administered one week after the last session to evaluate the reducing the depression among senior citizens of the old age home. effectiveness of the Structured Teaching Program. Analysis revealed statistically significant (p=0.001) increase in the post-assessment of 12. A randomized controlled study to assess the effect of yoga Mother-Infant Bonding values following the STP, indicating that it therapy on heart rate variability and self-perception of health was effective in increasing the bonding between mothers with mental among the inpatients with schizophrenia at NIMHANS illness and their infants. The study has significant implications for Bengaluru. Ms. Asha Vijayan. Guides: Dr. Ramachandra, nursing education, service, administration and research. Dr. Shivarama K Varambally
9. An experimental study to assess the effect of selected raga of Patients with schizophrenia were randomly allotted to either Yoga with music on aggression in children admitted in Child Psychiatry conventional care (Y) (n=25) or conventional care (Cc) (n=25). Those Center, NIMHANS, Bangalore. Ms. Jesna CA. Guides: Dr. in the yoga group were taught a specific yoga module with Asanas and G Radhakrishnan, Dr. Chittaranjan Andrade Prannayama (1 hour a day) for 12 sessions. Fifteen minutes resting lead II electrocardiogram was obtained. Improved vagal control with A study design with experimental group and control group was sympathetic suppression was observed in patients with schizophrenia adopted. Forty subjects who met the inclusion criteria were recruited after yoga intervention. Patients with schizophrenia showed improved for the study consecutively. Music intervention based on Raga heart rate variability with yoga as an adjuvant therapy compared to Shakarabharanam was administered for 20 minutes twice daily for conventional care. two weeks. Level of aggression measured in the four time points, prior to the intervention, 7th day, 14th day and 21st day. However, the 13. Effect of Video Assisted Psycho-Education [VAPE] about findings showed that Raga Shakarabharanam had minimal effect on mother and infant health on knowledge among primary reducing aggression among children with mental illness. caregivers of patients with psychiatric illness in the mother- baby ward, at NIMHANS, Bengaluru. Ms. Linsu Thomas. Guides: Dr. Sailaxmi Gandhi, Dr. Geetha Desai 10. Effectiveness of structured teaching program on burden among primary caregivers of inpatients with mania at The present study, based on one group pre-test–post-test design, was NIMHANS, Bengaluru. Mr. Subin Scaria. Guides: Dr. conducted in the mother-baby unit, NIMHANS, Bengaluru (N=25 Sailaxmi Gandhi, Dr. T Sivakumar mothers). The Video Assisted Psycho-Education [VAPE] consisted of three sessions lasting for 30 minutes, over three consecutive days. The researcher adopted a pre-experimental design (one-group pre- Post-test was done immediately after the last session. Analysis test post-test), and convenience sampling was used to collect data revealed statistically significant (p<0.001) increase in the post-test from 30 primary caregivers of inpatients with mania. The data mean knowledge scores following the VAPE sessions. The findings was collected at pre intervention, immediate post assessment and significantly support that the VAPE was effective in increasing the follow-up assessment after one week. Results showed that there knowledge of the primary caregivers on mother-infant health. The was a statistically significant (p<0.01) reduction in mean scores of study has implications in nursing education, service, administration, burden level from pre intervention to immediate post and follow up research and perinatal mental health. assessment stage. The researcher concluded that caregivers experience high level of burden because of patient’s illness. Hence, caregivers and 14. Effectiveness of a Structured Teaching Program on the mental health professionals need to be trained in dealing with the knowledge and attitude towards Cessation of Tobacco caregiver burden. Chewing among female housekeeping staff, NIMHANS, Bengaluru. Ms. Maya. Guides: Dr. Prasanthi Nattala, Dr. 11. Effect of art therapy on depressive symptoms among senior Arun K
204 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
The present study tested the effectiveness of a Structured Teaching weeks – 113/114 (99%), 24 weeks – 105/109 (96%) and 36 weeks – Program (STP) on Cessation of Tobacco Chewing on knowledge 66/80 (83%). and attitude among female housekeeping staff, NIMHANS (N=35). The STP consisted of three sessions on three consecutive days. Post- 3. Effect of yoga on yoga therapy on peripheral blood test 1 was administered on the day of last session, post-test 2 after lymphocyte mononuclear cell (PBMC) response to stress 2 weeks, and post-test 3 after 4 weeks following the last session. in patients with depression. Investigators: Dr. Shivarama Results revealed statistically significant (p<0.001) improvement in Varambilly, Dr. Rita Christopher, Dr. Naren P Rao (Funding the post-test knowledge and attitude towards tobacco chewing. The by NIMHANS) findings support that the STP was effective in improving the subjects’ knowledge and attitude regarding cessation of tobacco chewing. Abnormalities in complex biological pathways and signaling mechanisms manifest in the case of depression. The efficacy of anti- 15. Technology addiction among undergraduate student nurses. depressants is debatable. The aim of the study is to explore the effects Investigators: Dr. Ramachandra, Dr. S Valliammal, Mrs. of yoga, which is an alternate form of treatment, on the molecular Bingi Rajeswari, Mrs. Sathyavathy N mechanisms contributing to the disease. Neuroplasticity is a key process affected in depression. The detrimental role of inflammation 16. Psychiatric patients’ admission experiences in to psychiatric on neuroplastic mechanisms is well studied. The prime objective is to hospital. Investigators: Dr. Ramachandra, Mrs. P show the effect of yoga on stress responses in a peripheral cell model Vijayalakshmi, Dr. K Lalitha, Dr. Suresh Bada Math in patients with depression.
4. Addressing concerns of women admitted to psychiatric Psychiatry institutions in India: An In-depth analysis. Investigators: Dr. Pratima Murthy, Dr. Naveen Kumar, Dr. Suresh Badamath, 1. Yoga and Schizophrenia- A Comprehensive Assessment of Dr. Prabha Chandra, Dr. Srikala Bharath, Dr. Poornima Neuroplasticity (Y-SCAN). Investigators: Dr. Shivaram S Bhola, Dr. Vranda, Dr. Sailakshmi Gandhi (Funding by Varambally, Dr. Mariamma Philip (Funding by Welcome National Commission for Women) trust – DBT) The general objectives of the study were to explore the clinical, social, 2. Preventing and Treating HIV Co-morbidities in India: cultural, familial, economic and legal factors likely to affect the lives of Multi-tiered Strategy for Women. Investigators: Dr. Prabha women with mental illnesses admitted to mental hospitals in India. The S Chandra, Dr. Nancy Reynolds, Yale University, USA, methodology included collection of data from each hospital related to Dr. Veena A Satyanarayana (Funding by Indian Council of infrastructure, staffing and admissions and discharges. The next phase Medical Research, India and National Institute of Health, involved visits to select mental hospitals. In-depth semi-structured USA) interviews were conducted with the Medical Superintendent, psychiatrists, clinical psychologists, psychiatric social workers, nurses The research project is a randomised controlled study assessing and from women inpatients (and family members if available). The feasibility, acceptability and preliminary efficacy of mHealth (Mobile report has been presented to the NCW and recommendations for health) intervention delivered by nurses for enhancing self-care and addressing human rights and mental health care issues, specifically treatment adherence among HIV infected women in India. The related to women, have been discussed. total sample size is 120, including 60 respondents in the treatment as usual group and the other 60 in the intervention group. In addition 5. Culturally sensitive communication and psychosocial skills to treatment as usual, the intervention group receives nurse-delivered training for health professionals involved in End of Life Care self-care counselling via mobile phone at fixed intervals over 16 – an Evaluation of Innovative methods. Investigators: Dr. weeks. Outcome measures are collected at baseline and at 4, 12, 24 Prabha Chandra, Dr. Ramachandra, (Funding in ICMR) and 36 weeks post-baseline. Outcome measures include antiretroviral treatment adherence, HIV-1 RNA, depressive symptoms, illness 6. A multicomponent intervention to reduce home-exposure perception, internalized stigma and quality of life. to second-hand smoke (SHS) during pregnancy and postnatal period: a randomised controlled trial. Investigators: The recruitment for the study was completed in November 2015. Dr. Prabha S Chandra, Dr. Pratima Murthy, Dr. Veena Intervention phone calls have been completed for 59 out of 60 Satyanarayana, Dr. Priyamvada Sharma, Dr. Rumana Haque respondents in the intervention group. Follow-up assessments are (Bangladesh), Dr. Atif Rahman (UK) (Funding by Department ongoing, baseline – 120/120 (100%), 4 weeks – 117/118 (99%), 12 of Biotechnology, India and Medical Research Council, UK)
National Institute of Mental Health and Neuro Sciences 205 Annual Report 2015-2016
It is a feasibility study with a qualitative arm aimed at developing an of women experienced some anxiety symptoms during pregnancy. intervention to reduce secondhand smoke exposure at home among 13.4% of women reported being subjected to physical, psychological pregnant women, followed by a pilot RCT. Qualitative interviews with or sexual abuse by their partner or family members. 19% of the women 30 pregnant women, 20 husbands and 10 family members have been had a preference for a male child. Overall 15% of the women felt completed. The interviews revealed a lack of knowledge regarding the current pregnancy to be stressful. Five neonatal deaths, three still impact of SHS on pregnant women. However, the respondents were births and one maternal death have been recorded in the cohort. keen on an intervention which was aimed at the husband as a driver of change with the woman being an enabling agent. The intervention 9. Functional MRI: A diagnostic tool for minimal cognitive materials are currently being developed in preparation of the pilot impairment and early Alzheimer’s dementia? Investigators: RCT. Dr. Srikala Bharath, Dr. John P John, Dr. Keshav Kumar, Dr. Jitendra Saini (Funding by DST, Government of India) 7. Early psychosocial predictors of child mental health: longitudinal study of shared and distinctive risk and Default Mode Networks (DMN) of 55 amnestic Minimal Cognitive protective factors in UK and India. Investigators: Dr. Prabha Impairment (aMCI), 62 mild Alzheimer’s disease (mAD) and 50 S Chandra, Dr. Helen Sharp (University of Liverpool, UK), age, gender, education, socioeconomic status matched healthy elderly Dr. Shoba Srinath, Dr. Geetha Desai, Dr. John K Vijaya subjects were assessed. These were correlated with clinical parameters Sagar, Dr. Thomas Kishore (Funding by ICMR, India and like cognitive functions, neuropsychological assessment, instrumental Medical Research Council, UK) activities/activities of daily life and neuropsychiatric symptoms. There were significant gray matter volumetric reductions in the fronto- The aim of the study is to study the early risk and protective factors temporo-parietal structures as well as RSN connectivity disturbances for childhood mental health problems, to identify prenatal and in DMN and executive network in aMCI. A significant positive infancy risks that are common to Western and South Asia populations linear relationship between parahippocampal gray matter volume and those that are distinctive. The study proposes the prospective, reduction and delayed recall scores was found. Patients with mild longitudinal postnatal follow-up of 850 women and their infants who AD had reduced baseline resting state functional connectivity within will be assessed at the ages of six months, one year and two years to the regions of DMN. It was found that functional connectivity was identify prenatal, parental/caregiving environment and developmental positively correlated with their cognitive performances (attention / processes that influence behavioural and cognitive outcomes in working memory task) suggesting the importance of DMN functional children and families over time. connectivity in the cognitive performance. Further, the DMN regions that positively correlated with the cognitive performances was spatially 8. Prospective assessment of maternal mental health study smaller in patients with mild AD whereas, larger in the cognitively (PRAMMS) Prevalence of Anxiety and Depression during healthy volunteers. Hence, in order to compensate the reduced DMN pregnancy and association with antenatal healthcare functional connectivity and cognitive functions frontal executive utilization and health behaviour and with pregnancy network is hyper-recruited as evidenced by the increased functional outcomes – a prospective study. Investigators: Dr. Prabha S connectivity in the frontal executive network. Chandra, Dr. Geetha Desai, Dr. Thennarasu K, Dr. Kavita V Jangam, Dr. Veena A Satyanarayana, Dr. Padmalatha 10. A study of telomere length in dementias. Investigators: Dr. Venkatram, Consultant Obstetrician and Gynaecologist, Srikala Bharath, Dr. Meera Purushotham, Dr. Sanjeev Jain President, Bangalore OBG Society, Dr. Aruna Muralidhar, (Funding by Indian Council of Medical Research) Consultant Obstetrician and Gynaecologist, Rangadore Hospital (Funding by ICMR) 11. Imaging genomics approach to identify molecular markers of lithium response in bipolar disorder. Investigators: Dr. The cohort-study (involving 700 pregnant women) aims at assessing Biju Viswanath (Funding by Department of Science and the prevalence of anxiety and depression during pregnancy, their Technology) relationship with health behaviours and risk factors for anxiety and depression in pregnancy. The study also aims at examining the 12. Effectiveness of street theatre to create awareness about relationship of antenatal factors with poor birth outcomes, namely schizophrenia: A randomized controlled trial. Investigators: preterm birth and low birth weight, and postpartum maternal and Dr. Santosh Loganathan, Dr. Mathew Varghese (Funding by mother-infant outcomes. More than 30% of the pregnant women NIH- Fogarty International Center) were married for a year or less. About 8% and 2.1% of the women had significant depressive symptoms during pregnancy and the postpartum The study aims to test the efficacy of an intervention that enhances respectively. 7.2% of women had suicidal ideation in pregnancy. 5.2% the knowledge, attitudes and beliefs about schizophrenia. A culturally
206 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 adapted theatrical performance (street play) by a professional group of PG Senior Resident (DM), Department of Child and artists was used as the intervention. The play was then compared with Adolescent Psychiatry, Ms. Nagalakshmi RM, Phd Scholar, two other controls: video recording of the play and psychoeducation. Department of Psychiatry The three interventions were randomized to three villages (n=100 in each village) where baseline assessments were conducted using 18. Therapeutic effects of yoga in depression: a neurobiological the WPA questionnaire on knowledge, attitude and beliefs. Higher investigation. Investigators: Dr. Muralidharan K, Dr. BN scores represented incorrect knowledge, stigmatizing attitude and Gangadhar, Dr. G Venkatasubramanian, Dr. Rose Dawn wrong beliefs. Street plays and other interventions showed significant Bharath, Dr. Monojith Debnath, Dr. Satyaprabha TN, Dr. reduction in knowledge and belief scores in the follow-up time. Mariamma Philip, Dr. Sneha J Karmani (Funding by DST, Between the three treatment groups reductions were observed among Govt. of India) knowledge, attitude and belief scores but were not significant. Attitude scores did not change significantly between follow-ups and between In this study, the investigators hope to assess the efficacy a non- treatment groups. pharmacological approach—Yoga, as an add-on treatment modality in patients with moderate to severe depressive illness. The effect 13. The International Prevalence and Treatment of Diabetes of Yoga will be assessed on clinical rating scales for depression and and Depression (INTERPRET-DD) study carried out its impact on neurobiological abnormalities commonly associated under the auspices of the International Dialogue on Diabetes with depression (conventional autonomic function tests and heart and Depression (DDD). Investigators: Dr. SK Chaturvedi, rate variability, cortical inhibition, complex emotional processing Dr Ameer Hamza, Dr. S Srikanta (Funding by Dialogues and blood biomarkers of inflammatory and oxidative/stress-related in Diabetes and Depression and Association for Mental pathways). The investigators propose to investigate the effects of yoga Health) (NIMHANS and Samatvam Diabetes Center) in addition to the standard treatment regimen for depression. They hypothesize that yoga as add-on treatment will have more efficacy in 14. Initial experience of rehabilitation services at Sakalawara depression compared to antidepressant alone and that the change in Community Mental Health Centre: Findings from review of biological markers (for e.g. improved cortical inhibition) would also case records and registers. Investigators: Dr. N Manjunatha, be more in the yoga+antidepressant group than the antidepressant Dr. Aravind, Dr. Aruna Kapanee, Dr. Mohan Krishna alone group. If addition of Yoga is found to be beneficial, this will benefit many patients with depression who have inadequate response 15. A study of reproductive and sexual health status and to standard antidepressant drugs, or who do not prefer to use drugs prevalence of sexual dysfunction among young individuals or undergo therapies like electroconvulsive therapy or psychotherapy, with mental and substance use disorder related disability. which also require specially trained personnel. It is expected that the Investigators: Dr. Shyam Sundar A, Dr. Harish T (Funding trend in change of biomarkers before and after intervention with by ICMR) Yoga will throw light not only on the added therapeutic potential of Yoga but may also indicate their predictive potential as biomarkers for 16. Clinical, cognitive and neuroimaging correlates of response to Yoga therapy in depression. apolipoprotien E (APOE) genotype in elderly with late onset depression: A prospective study. Investigators: Dr. 19. Performance on line bisection and emotion recognition tasks PT Sivakumar, Dr. Sanjeev Jain, Dr. Thennarasu, Dr. in subjects with unipolar and bipolar depression compared Venkatasubramanian G, Dr. Jitendra Saini (Funding by to healthy subjects. Investigators: Dr. Muralidharan K, Dr. ICMR) Venkatasubramanian G, Dr. Naren P Rao, Dr. Janardhanan CN, Dr. Aditya Hegde, Dr. Rashmi Arasappa, Dr. Gayatri D, This study evaluated the sub regional volumetric changes of Dr. Aditi Singh Hippocampus in the elderly with late onset depression. Forty three elderly patients with late onset depression were evaluated with APOE Depressive episodes can occur in both unipolar major depression genotyping, clinical, cognitive assessment and structural MRI. Follow- and bipolar disorder. Unipolar major depression (UD) has been up assessment was done after one year to evaluate the hippocampal demonstrated to be significantly different from Bipolar Depression volumetric change and study its clinical and cognitive correlates. (BD) and has been widely documented. BD differs from UD in symptomatology, course, family history of bipolar disorders 17. A retrospective study of clinical profile in patients with and response to antidepressant treatment. It has been repeatedly Down’s syndrome. Investigators: Dr. Miriyala Srikanth, demonstrated that a lack of relevant biological markers for BD Non PG Senior Resident Department of Psychiatry, Dr. PT frequently results in a misdiagnosis of UD in at least 60% of patients Sivakumar, Dr Satish Chandra Girimaji, Dr. Pooja Panchal, presenting with a depressive episode for treatment. The investigators
National Institute of Mental Health and Neuro Sciences 207 Annual Report 2015-2016 propose to study the performance on line bisection task as a measure of College, Ernakulam, Dr. Preethi K, Assistant Professor cerebral asymmetry and performance on facial emotion recognition— (Dermatology), Government Medical College, Ernakulam, matching and labelling tasks as means of differentiating unipolar from Dr. Meera James, Consultant Dermatologist, Beau bipolar depression. A group of healthy subjects will serve as a control Aesthetica, The Cosmetic Dermatology Clinic, Panampilly group for this study Nagar, Kochi, Dr. Rahul KK, Consultant Dermatologist, KKRIS Skin Care Centre and Laser Centre, Chalakudy, 20. Accelerator program for discovery in brain disorders using Ernakulam stem cells. Investigator: Dr. Sanjeev Jain (Funding by Department of Biotechnology) 24. Endocannabinoid-Glutamatergic Interactions in OCD. Investigators: Dr. Janardhanan CN, Prof. YC Janardhan The mission of this proposal is to nucleate a program of research Reddy, Dr. Ganesan Venkatasubramanian (Funding by DBT) to understand the development and mechanistic basis of common, serious psychiatric disorders in the Indian population. It is proposed The study aims to examine the relationship between plasma to do this through a long-term, integrated and collaborative effort anandamide and in-vivo glutamate measures (MRS - Imaging) in involving specialist clinicians from NIMHANS as well as scientists OCD. The additional measures are functional MRI (mental-rotation from NCBS/inStem with expertise in understanding the cellular and paradigm) and eye tracking (anti-saccade). The study is on-going. molecular analysis of biological processes. This application to the DBT, Govt. of India is for a five year proof of principle activity to 25. Neural and immunological Predictors of SSRI response nucleate this long term effort. In this application, the investigators in OCD. Investigators: Dr. Janardhanan CN, Prof. YC propose to set up a prospective, longitudinal cohort of patients with Janardhan Reddy, Dr. Ganesan Venkatasubramanian adult onset psychiatric disorders including at-risk subjects with genetic (Funding by DST) predisposition as well as asymptomatic controls. These cohorts will be followed from childhood/young adults over a period of 20 years. The The study aims to examine the neurobiological correlates of SSRI members of the cohort will be subjected to a uniform set of clinical response in OCD, using a longitudinal design. The markers under analysis and a biorepository will be set up using cellular material from consideration are brain imaging (structural and functional imaging) these individuals. It is expected that deep interrogation of brain and immune parameters (cytokines). networks (via brain imaging and clinical electrophysiology) as well as sub-cellular networks using molecular and cellular analysis would 26. Diagnosis and treatment response in antipsychotic naive lead to better mechanistic understanding of these disorders. These Schizophrenia: A clinical and arterial spin labeling study. findings should lead to better diagnostic and therapeutic approaches Investigators: Dr. Shivarama Varambally, Dr. Naren P Rao, for patients with psychiatric disorders as well as fundamental new Dr. Venkatasubramanian, Dr. BN Gangadhar (Funding by insights into the function of the human brain. Central Research Fund, University of London)
21. Prevalence of common mental disorders, alcohol and tobacco The study aims to investigate: (a) whether antipsychotic-naive use among primary care attendees including adolescent/ schizophrenia patients have more NSS and altered rCBF compared to geriatric subjects in the state of Kerala, India. Investigators: controls (b) whether markers for treatment response can be identified Dr. Sunil Kumar G, State Programme Manager, National clinically and in basal resting state CBF before antipsychotic treatment Health Mission, Dr. TS Jaisoorya (Funding by National is administered in first episode, antipsychotic naïve, patients with Health Mission, Kerala) schizophrenia (c) whether immediate significant increase (i.e. four hours after first dose) in rCBF in basal ganglia, frontal & temporal 22. Impact assessment of JSSK/JSY, vaccination coverage and brain regions and lower NSS scores will predict significant clinical psychological/physical health of mother/baby dyad – A improvement at the end of six weeks and (d) if temporal course of state wide study. Investigators: Dr. Sunil Kumar G, State blood flow changes according to treatment response to understand Programme Manager, NHM (Kerala), Dr. TS Jaisoorya, biological mechanisms involved in different antipsychotic action. Dr. Manoj L (DPM, NHM, Kerala) (Funding by National Health Mission, Kerala) 27. Pattern and prevalence of Axis I Psychiatric Comorbidity in patients with Substance Use Disorders – [PsyCoSUD]. 23. Prevalence and comorbid patterns of OCD and related Investigator: Dr. Arun Kandasamy (Funding by NIMHANS) disorders in dermatological settings. Investigators: Dr. TS Jaisoorya, Dr. YC Janardhan Reddy, Dr. Deepa Augustine, 28. Consortium on Vulnerability to Externalizing Disorders and Assistant Professor (Dermatology), Government Medical Addiction (c VEDA). Investigators: Dr. Vivek Benegal, Dr. K
208 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Thennarasu (Funding by Medical Research Council, UK & The goal of this project is to strengthen manpower, formulate ICMR, India) training module, conduct research and do quality control for Oral Substitution Treatment (OST) centres in opioid use disorders across 29. Alcohol: Harms to others -India. Investigators: Dr. Vivek South India. More than 200 health professionals have been trained Benegal, Dr. Girish Rao (Funding by World Health with regard to the use of buprenorphine, safe needle methods, and Organisation and Thai Health) co-morbidities, so far.
The household survey of the study examined the harmful impact 35. Skill Building in treatment of Alcohol and Tobacco of alcohol use, on persons other than the drinker in eight countries, use Disorders for Doctors and Counsellors from State including India. In India, 45% of the people reported having Health Society, Government of Bihar: A blended training. suffered harm from drinking strangers and known persons. The Investigators: Dr. Prabhat Chand, Dr. Arun K (Funding by social determinants of such harm have implications for public health State Health Society, Bihar) planning. Centre for Addiction Medicine (CAM), NIMHANS trained 28 30. Rehabilitation needs of persons with schizophrenia in rural doctors/primary health physicians trained in the area of alcohol and communities. Investigators: Dr. Naveen Kumar C, Dr. tobacco use disorders, as part of the training programme conducted Thirthalli J in association with State Health Society, Government of Bihar in February-March 2016. These trained health professionals will serve 31. Explanatory models of illness and the use of traditional as master trainers and also provide de-addiction services at the complementary and alternative system of medicine among district hospitals in Bihar. After on-site training, each district team rural patients with psychiatric disorders. Investigators: Dr. will be supported by handholding and co-managing challenging Naveen Kumar C, Dr. Thirthalli J patients through online Virtual Knowledge Network NIMHANS by using ECHO model. ECHO teleHealth sessions, conducted once 32. Comparison of antipsychotics for non-neurological adverse every two weeks, through multi-point videoconferencing, includes effects: Pilot study. Investigators: Dr. Preeti Sinha, Dr. components of both case based learning (i.e. case presentations Chittaranjan Andrade. by these doctors/counsellors from Bihar or ‘spokes’ combined with guided practice by multidisciplinary expert team at the ‘hub’ 33. NIMHANS ECHO: Virtual Knowledge Network with i.e. NIMHANS) and didactic sessions by hub experts. The team Project ECHO, University of New Mexico, US: Impact and strongly believes that this blended training as well as handholding effectiveness of online training in addiction mental health. will increase the confidence of doctors and counselors and will Investigators: Dr. Prabhat Chand, Dr. Arun K translate to better patient care in their community. For details, visit http://bit.ly/nimhans_bihar_echo The ongoing weekly NIMHANS ECHO tele-Health sessions, conducted through multi-point videoconferencing, consist of 36. Turning the Pages. Investigator: Dr. Pratima Murthy components of both case based learning (i.e. case presentations by (Funding by Wellcome project) community practitioner or ‘spokes’ combined with guided practice by multidisciplinary expert team at the ‘hub’—NIMHANS) and 37. Validation of an MCessation module for tobacco cessation. didactic sessions by hub experts. The doctors also present clinical Investigator: Dr. Pratima Murthy (Funding by World Health cases and seek clarification regarding standard management from Organization) the multidisciplinary team as well as peers who have logged in simultaneously. Over the last one year, 1000 health professionals 38. Status of women admitted to mental institutions National from India and neighboring countries participated in 60 online live Commission for Women. Investigators: Dr. Pratima Murthy, tele-Health sessions. On average, 30 spokes participated in each Dr. Naveen, Dr. Prabha S Chandra, Dr. Srikala Bharat session. Recently, doctors from various district hospitals of Bihar (Funding by World Health Organization) were trained to manage patients with alcohol dependence in their districts. 39. Parental consanguinity and its association with metabolic abnormality in schizophrenia patients living in a rural 34. Regional technical training centre for injecting opioid use community of South India: A clinical and genetic disorders NIMHANS. Investigators: Dr. Prabhat Chand, investigation. Mr. Vikas Agarwal. Guides: Dr. Jagadisha Dr. Arun K (Funding by Global Fund against TB, AIDS and Thirthalli, Dr. Rita Christopher, BN Gangadhar, Dr. Naveen Malaria--GFTAM 9) Kumar C
National Institute of Mental Health and Neuro Sciences 209 Annual Report 2015-2016
The aim of the project is to examine the prevalence and degree of 43. Role of copper in Alzheimer’s Dementia- a controlled study. parental consanguinity in schizophrenia patients, vis-à-vis control Dr. Siddhesh S Shere. Guides: Dr. Srikala Bharath, Dr. population in a rural community. The investigators have identified Sarada Subramanian, Dr. Meera Purushottam about 250 patients and 301 randomly selected controls from the community. Genomic DNA has been isolated from 200 and 300 The essential metal ion copper is intriguingly connected with the patients and controls respectively. Clinical data regarding parental established molecular markers of Alzheimer’s disease and that copper consanguinity has been collected from 223 and 157 schizophrenia homeostasis is disturbed in affected individuals, leading to oxidative patients and controls respectively. There is no significant difference stress and neurodegeneration. in parental consanguinity: 9.86% of schizophrenia patients and 8.28% of controls report parental consanguinity. The genetic data is yet to The findings of this study showed no significant difference in be analyzed. levels of serum ceruloplasmin between the AD and healthy control groups. However, a near-significant decrease in copper in the AD 40. Molecular basis of neuroplastic effects of yoga on major was observed which is consistent with reduced copper-dependent depressive illness. Ms. Aditi Devi N. Guides: Dr. Shivarama biochemical activities such as cytochrome c oxidase (required for Varambally, Dr. Rita Christopher energy generation) and SOD (free radical scavenger) described in AD
The objectives of this research are to elucidate the effect of yoga 44. Lithium prophylaxis and Neurotrophic/Neuroprotective on peripheral blood mononuclear cell (PBMC) response to stress genes: An association study and gene expression analysis by lipopolysaccharide challenge in patients with depression, and to in patients of Bipolar disorder. Dr. Ravi Kumar Nadella. determine the changes in proBDNF/BDNF ratio, tPA and MMP-9 Guides: Dr. Sanjeev Jain, Dr. Biju Vishwanath levels in patients with depression on yoga therapy. Sample of 226 patients with Bipolar Disorder (BD) who have taken 41. Salivary alpha amylase levels in mothers with postpartum lithium once in their life time have been recruited. The characterization psychosis: an indicator of stress response and clinical of response to lithium is performed using NIMH Retrospective Life correlates. Dr. Sai Komal. Guides: Dr. Harish T, Dr. Rita Chart and “ALDA” scale (N=187). Alda score ≥7 are considered Christopher, Dr. B Binukumar, Dr. Prabha S Chabdra Excellent Responders (ER), Non-Responders (NR) score ≤3 and others Partial Responder (PR). BDNF rs6265 (N=183) and Bcl-2 rs956572 The primary objective of this study is to determine the salivary-alpha (N=163) genotyping data was obtained. No association was found amylase (SAA) levels as a stress response in postpartum psychosis. between lithium response in BDNF and Bcl-2 polymorphism. A pilot The secondary objectives are to study the changes in SAA levels experiment for Bcl-2 gene expression in LCL model has not shown any and its association with mother infant bonding and to elucidate the difference between case and control with lithium treatment. changes in SAA levels over the period of recovery. 45. Comparison of Brain Symmetry in patients with 42. An exploratory study of the link between white matter Schizophrenia and Bipolar Disorder using Eye Tracking integrity and serum levels of S100-B, a peripheral and Line Bisection Tasks. Dr. Surabhi Hiwale. Guides: Dr. biomarker of neuronal integrity in schizophrenia. Dr. Shivarama Varambally Dr. G Venkatasubramanian , Dr. Nitin Ambekar. Guides: Prof. John P John, Dr. Sarada Naren P Rao Subramanian Schizophrenia and Bipolar Disorder are serious psychiatric Schizophrenia is a severe mental illness with significant anatomical disorders, having neurodevelopmental origins. Neurological soft disruption in white matter integrity. Diffusion tensor imaging which signs and hemispheric asymmetry are markers of such aberrations of can measure the white matter abnormality in terms of fractional development. The investigators combined tools that indicate cerebral anisotropy indicated that white matter abnormalities are not asymmetry (LB task, visual scan differences) and neurological soft significant in schizophrenia. signs to discriminate groups of patients of schizophrenia, bipolar disorder and healthy individuals. The investigators hypothesized In schizophrenia, activated microglia and astrocytes release several that they would be able to differentiate patients with SCZ and factors including S100B into the blood. When the serum S100B levels BPAD based on their performance on Line Bisection and visual scan were measured, it was found that they were not significantly increased analysis. They also proposed a positive correlation between deviation in recent onset schizophrenia. However, elevated serum S100B levels from true centre in LB task and NSS scores. Thirty one patients with could be correlated with chronicity of the illness. SCZ, 34 with BPAD and 28 healthy controls were recruited based
210 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 on predefined inclusion and exclusion criteria, with their written functions. tDCS procedure was conducted with safety precautions informed consent. Psychopathology scores were rated using SAPS, as per established practice and all the patients (n=21) tolerated the SANS, YMRS and HDRS. Schizo-Bipolar scale was also applied. sessions well without any major side effect. Analysis using paired-t tests and spearman’s correlation revealed significant improvement Two-hand line bisection task was administered, separately for each in insight after 10 sessions of tDCS while auditory hallucinations hand. Visual scan analysis was done using faces as stimuli, with a total score showed significant reduction. Eye movement variables like final of eighteen trials. Significant difference (p <0.05) in line bisection eye position gain in anti-saccade task, velocity and position gain in task performance between groups of SCZ and BPAD and SCZ and fast trial smooth pursuit task showed significant change, and with HC was found. No differences were found between the groups on eye available data significant improvement was observed in cognitive tracking analysis. No correlation was seen between NSS scores and mean domain namely visuo-motor speed also. The changes in insight had percentage deviations on LB task. This study supports the use of LB task positively correlated with changes in the clinical profile of the patient, as a tool to help discriminate SCZ patients from BPAD patients, adding few eye movement changes and changes in cognition. to the evidence of its use to detect subtle neurological anomalies. 48. Factors associated with treatment retention and yearly drop 46. Prevalence of epilepsy in people with psychotic illness and out in vuprenenorphine maintenance treatment for opioid their first degree relatives. Dr. Linda Sherine A. Guides: Dr. dependence syndrome. Dr. Partheeban. Guides: Dr. Prabhat V Senthil K Reddi, Dr. Sanjeev Jain Kumar Chand, Dr. Pratima Murthy, Dr. Arun Kandasamy and Dr. Priyamvada from Sharma Toxicology under CAM Numerous studies have found increased prevalence of psychosis in patients with epilepsy. Only few studies have been dedicated to The study looked at the short term outcome and factors associated examine prevalence of epilepsy in patients with psychotic illness and with treatment retention and early drop out in patients receiving the results were inconclusive. The primary objective of this study was buprenorphine maintenance therapy (BMT) for opioid dependence. to see prevalence of epilepsy in patients with psychotic illness and their It was a prospective treatment cohort study including 89 patients. first degree relatives and to compare it with those without psychotic Prospective follow-up of these patients was carried out six weeks illness and their first degree relatives. For this, 155 patients with DSM after initiation of the BMT. This study shows an increase trend in IV diagnosis of Schizophrenia, BPAD Schizoaffective Disorder were the use of natural opioids along with pharmaceuticals among patients. compared to 167 patients without psychotic illness (mild depression, Based on the study, it was concluded that buprenorphine is effective, anxiety, somatic symptom disorder, dysthymia). All of them were with greater retention rates and reduced opioid abuse. Results from recruited from Adult Psychiatry Ward/Unit, NIMHANS. It was the study support the finding that BMT dispensing on take-home found that prevalence of seizure in patients with psychotic illness basis has good retention (69.7%). Many of the factors associated with was (12.2%) higher than in controls and there was no increase in barriers to treatment retention have implications for improving clinical occurrence of seizure in first degree relatives. The finding also suggests practice, policy decisions, or future research. For example, two reasons the neurobiological and genetic basis for psychotic illness. for study discontinuation (unavailability and travel) can be overcome by community treatment. Patients who were on relatively higher 47. Clinical, cognitive and eye movement correlates of insight doses of buprenorphine (>6mg) might have had reduced craving for modulation with add-on tDCS in Schizophrenia. Dr. the primary opioid of abuse and this may have made them remain Dinakaran. Guides: Dr. Venkatasubramanian G, Dr. abstinent and compliant with BMT. The results further support the Shivarama Varambally, Dr. CN Janardhanan literature on adequate dose of buprenorphine during induction phase is crucial in retaining patients in early phase of treatment. Efficiency Transcranial Direct Current Stimulation (tDCS) is a re-emerging, in improving withdrawal symptoms and alleviating craving were safe, non-invasive, portable, and relatively cheaper brain stimulation the most common facilitator and intolerance to medication and tool. Interestingly, it is seen as a potential tool to improve cognition programme related (distance, unavailability) were the most commonly in healthy individuals and as an add-on option to treat patients with perceived barrier by the patients. Understanding the patient-related resistant auditory hallucinations. This study was undertaken with the and program-related factors that are associated with treatment aim to understand the clinical, eye movement and neurocognitive retention and drop-out may provide insights into preventable factors correlates of insight modulation with tDCS as an add on option that contribute to premature drop out from BMT. to ongoing stable antipsychotic drug treatment in patients with persistent auditory hallucinations. It was hypothesised that the 49. 2D: 4D ratio in patients of depression. Dr. Spandana Bokka. improvement in insight following tDCS would positively correlate Guides: Dr. C Naveen Kumar, Prof. Jagadisha, Dr. PT with improvement in clinical status, eye movement and cognitive Sivakumar
National Institute of Mental Health and Neuro Sciences 211 Annual Report 2015-2016
The objective of the study was to compare the digit ratio (2D:4D) information and time constraints. Whereas self-advocacy, early in recurrent depressive disorder patients and normal healthy controls. engagement, education of women and involvement of the family with Thirty recurrent depressive disorder patients and 30 controls were service providers were the facilitating factors. A widespread idea that included in the study after the inclusion and exclusion criteria were mentally ill women cannot be ‘good mothers’ was common and the met and 2D:4D was measured in both the hands in both cases and services for parenting were inconsistent and lacking. The implications controls using Vernier calipers. The 2D:4D ratio was more in the in terms of suggestions, health-care service needs and provisions for patient group as compared to the control group, in both right and left policy making were discussed subsequently. hands but was not found to be statistically significant. Comparison with absolute digit lengths in male patients and male controls showed 52. Cortical Inhibition with paired-pulse TMS, neurological soft that right and left 2D lengths were more in male patients than male signs, minor physical anomalies and interleukin 6 in recently controls, which was statistically significant (feminization of fingers diagnosed bipolar I disorder and subjects at high risk for found in male patients). bipolar disorder compared to healthy subjects. Dr. Sanjay T Naik. Guides: Dr. Muralidharan K, Dr. Venkatasubramanian 50. Vulnerability to addiction and creativity. Dr. Machewad G Nitish Kumar Bapura. Guides:Dr. Vivek Benegal, Dr. Venkatasubramanian G, Dr. Roase Dawn Bharath, Dr. 53. Pharmacogenetic association of glutamate transporter gene Jamuna Rajasekaran, Dr. Shantala Hegde and SRI response in OCD. Dr. Tulika Shukla. Guides: Dr. YC Janardhan Reddy, Dr. Sanjeev Jain Dr. Meera Purushottam A total of 29 children with and without family history of alcohol Dr. Biju Viswanath dependence syndrome (ADS) have been recruited for exploring relationship of externalizing symptoms and creativity along The study aimed to look at the pharmacogenetic association between with functional magnetic resonance imaging (fMRI) correlates. SLC1A1 (glutamate transporter gene) and drug response in OCD. The Wallach-Kogan Creativity Tests (WKCT), childhood and adult investigators evaluated 430 patients with OCD whose genotyping for behaviour checklist (CABCL), were used for assessing creativity and SLC1A1 was done. The patients were classified into SRI Responder externalizing symptoms; fMRI analysis included activation during (>35 % reduction in YBOCS), Non-Responder (<25 % reduction task and connectivity during rest and task. The children with family in YBOCS), Partial Responder and inadequate trial categories. The history of ADS have higher externalizing and creativity scores along investigators got 187 responders and 91 non responders as per the with stronger activation of Default Mode Network (DMN) during a-priori criteria. There was no relation between SLC1A1 rs3056 task, weaker connectivity within nodes of DMN and weaker anti- polymorphism and drug response in OCD. For the second part of the correlation between DMN and Task Positive Network (TPN). study LCLs from four SRI responders and two SRI non-responders were taken and treated with fluoxetine (10uM) in vitro for three days, 51. Child bearing and rearing experiences in mothers with severe following which change in SLC1A1 gene expression was seen. The mental illness: a qualitative study. Dr. Debanjan Banerjee. study showed that there was a change in SLC1A1 gene expression Guides: Dr. Geetha Desai, Dr. Prabha Chandra after addition of fluoxetine but not associated with response status of the patient. This qualitative study with social constructivist paradigm, tried to analyze in depth the varied factors through which a mother 54. An exploratory study of resting state brain functional with mental illness goes, throughout the process of ‘deciding to connectivity and its association with S100B in major bearing to rearing’ a child. Thirty women with depression/Bipolar depression. Dr. Venkata Lakshmi Narasimha. Guide: Dr. affective disorder/Severe depression attending a tertiary health-care John P John facility were interviewed with semi-structured interview-schedule. Thematic analysis was done subsequently with grounded theory This study was carried out on 20 patients diagnosed with DSM- methodology. The varied experiences were arranged along the pre- IV-TR Major Depressive Disorder (anti-depressant naive and anti- pregnancy and post-pregnancy timelines. Overall: feelings for the depressant naive free) compared with 20 age, gender and education child (ambivalence, possessiveness, guilt), impact of illness (stigma, matched healthy controls. The main findings of this study are: (i) symptoms, medication), unmet needs (for shared responsibility, Resting state functional disconnectivity in DMN is not present in emotional support, support groups) and caregiver reaction (blame, patients with antidepressant naïve/anti-depressant free recent onset discrimination, custody threats) appeared as the main categories (and mild-moderate major depressive disorder group when compared themes). Most women considered motherhood ‘central’ to their lives with the age, gender and education matched control group (ii) and almost all of them experienced the burden of the ‘dual role’. Main Resting state functional connectivity changes in cerebellum (whole barriers in seeking help were stigma, treatment side-effects, wrong brain) and nucleus accumbens, thalamus, middle temporal gyrus,
212 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 anterior cingulate cortex, amygdala, posterior cingulate cortex, and commonly prescribed antidepressant is amitriptyline at dosage 10- periaqueductal grey matter (connectivity analysis restricted to a priori- 25mg. Benzodiazepines are being prescribed mainly for anxiety and defined ROIs) emerged (iii) Serum S100B levels were not elevated sleep. The most commonly prescribed benzodiazepine is Alprazolam in mild-moderate Major Depressive Disorder patients group when 0.25mg - 0.5mg. The duration of prescription is usually short for 1-2 compared with the age, gender and education matched control group. weeks. Around 20-40% people come for a repeat prescription. The predominant factors influencing psychotropic prescription are age, 55. Investigating the role of one-carbon metabolism pathway gender, affordability issues and patient pressure. GPs find it difficult in complicated alcohol withdrawal states. Dr. Kukarni to convince the need for visiting a psychiatrist due to the prevalent Karishma Rajendra. Guides: Dr. Pratima Murthy, Dr. stigma against mental illness. The GP’s are unaware of criteria for Sanjeev Jain, Dr. Biju Vishvanath, Dr. Meera Puroshottam, depression. Diagnosis is often made on self-report of sadness by Dr. Priyaamvada Sharma, Dr. Prabhat Kumar Chand the patient. GPs find it important to check into the psychosocial circumstances in psychiatric illnesses. Existing evidence suggests that chronic alcohol dependence syndrome (ADS) and associated deficiency of vitamin B12 and folic acid leads 57. Insulin resistance in Alzheimer’s dementia. Dr. Sreelakshmi to hyperhomocysteinemia through inhibition of methionine synthase Thankappan. Guides: Dr. Srikala Bharath, Dr. Sharada (MS) and methylene tetrahydrofolate reductase (MTHFR) enzymes Subramanian, Dr. Meera Purashottam, Dr. Preeti Sinha of the one carbon pathway. The study aimed to investigate the association of MTR A2756G (responsible for the MS enzyme) and Alzheimer dementia is a neurodegerative disorder and dysfunction MTHFR A1298C polymorphisms with complicated withdrawal i.e. of insulin signalling pathway is considered as on the risk factor. The AWS and delirium tremens (DT). The levels of vitamin B12, folic current study aimed at assessing the level of insulin resistance in AD acid and homocysteine were also measured in these patients. The patients and also correlation with degree of cognitive deficits and sample consisted of a total of 150 male patients with ADS of which APO E4 genotype status. In this hospital based cross sectional study 84 patients had simple withdrawal state (SWS), 30 patients had DT 40 AD patients and controls were assessed for cognitive deficits along and 36 patients had AWS. with peripheral insulin level monitoring and Apo E genotyping. This study did not find any statistically significant difference in the level of The study found no differences in the serum homocysteine levels insulin resistance among patients and control or Apo E4 genotyping. (SWS – 0.91; DT – 0.91; AWS – 0.88 nmol/ml, t = 0.9, p = 0.6), However deranged glucose and lipid level showed correlation with vitamin B12 levels (SWS – 274; DT – 265; AWS – 230 pg/ml, t = 1.2, severity of dementia. p = 0.5), and folate levels (SWS – 99.3; DT – 99.1; AWS – 98.2 pg/ ml, t = 2.4, p = 0.1). Although vitamin B12 and folic acid levels fell in 58. Examining Gender differences in social cognition and its the lower end of the normal range, no deficiency states were observed. association with parenting in Schizophrenia. Dr. Deepa No association was found between MTR A2756G and MTHFR Nathan. Guides: Dr. Prabha S Chandra, Dr. Sathish C A1298C and complicated alcohol withdrawal states in our population Girimaji, Dr. Geetha Desai, Dr. Urvakhsh Mehta
56. Prescribing patterns of antidepressants and anti-anxiety The study aimed at (i) comparing social cognitive deficits in drugs among general practitioners in Bangalore city. Dr. mothers and fathers with schizophrenia (ii) assessing relationship Jayakrishnan Menon TN. Guide: Dr. SK Chaturvedi of parenting and social cognition deficits in mothers and fathers with schizophrenia (iii) comparing social cognition in patients This study aimed to examine the prescribing patterns of antidepressants when compared to healthy volunteers. A tool was devised to and anti-anxiety drugs among GPs in Bangalore city. The knowledge assess parenting in psychiatric disorders as part of the study. of GP with respect to prescribing these medications in various A pilot study was done with 10 schizophrenia patients and 10 pertinent clinical scenarios was also assessed. healthy controls. Content validation was done by seven subject experts. The main study included 35 cases (16 mothers and 19 The participants were assessed through a semi structured questionnaire fathers with schizophrenia) and 35 controls (healthy mothers using data compiled from previous studies of similar nature. In and fathers), matched for age and domicile. Both groups were addition representative case vignettes to assess their knowledge assessed by parenting tools (the new tool and GSDS), KIDDIE and prescription patterns for various clinical scenarios were also TRENDS tool (facial emotion recognition) and SOCRATIS provided. Around 5-10% of all patients seen in general practice can (first order and second order theory of mind tests). The patient be ascribed a psychiatric diagnosis as per GP’s. The predominant group had significant social cognition deficits across all domains indications for which antidepressants are being used are for the that were assessed with no significant difference amongst treatment of depression, chronic pain conditions and sleep. The most mothers and fathers with schizophrenia. The patient group also
National Institute of Mental Health and Neuro Sciences 213 Annual Report 2015-2016 had significant parenting deficits across all domains of parenting chemoattractant protein-1 (MCP-1/CCL2), which substantiates measured by the tool, when compared to the healthy control the role of immune system dysregulation in the pathophysiology of group. There was no significant difference amongst mothers and PPP. fathers with schizophrenia. Significant correlation was observed between parenting and social cognition when both groups were 61. Prevalence of sensory phenomena (SP) in OCD and its taken as a whole, however correlation between social cognition clinical correlates. Dr. Sushma BH. Guides: Dr. Suresh Bada deficits and parenting deficits could not be established in the Math, Dr. Janaradhanan CN, Dr. Janardhan Reddy YC, Dr patient group alone. Shyamasundar
59. Development and pilot testing of an interview schedule for A sample of 71 patients with OCD was recruited from the OCD assessing factors influencing educational outcome in students clinic for assessing the prevalence and clinical correlates of Sensory with schizophrenia. Dr. Abhijna Chattopadhyay. Guides: Dr. Phenomenon (SP). Yale Brown Obsession Compulsion Check List, Naveen Kumar C, Dr. Jagadisha T, Dr. T Sivakumar, Dr. Yale Brown Obsession Compulsion Severity Scale, Dimensional Urvaksh Mehta Yale Brown Obsession Compulsion Rating Scale, Mini Plus and University of Sao Paulo Sensory Phenomena Rating Scale are used The first stage of the study consisted of qualitative interviewing of for assessment. The study showed that sensory phenomena (50.7%) patients with schizophrenia/schizoaffective disorder and caregivers were highly prevalent in OCD and associated with early age of onset, for factors both hindering and helping individuals affected by this higher severity of OCD and predominant compulsions. illness, carried out in four phases. Based on the interviews, a schedule for systematic assessment of factors influencing educational outcome 62. A descriptive study of catatonic symptoms and syndromes in schizophrenia was compiled and sent to experts for validation. in Psychiatry and neurology in inpatient service. Dr. Seby The final schedule contained a list of hindering and helping factors, Kuruth Kulungara. Guides: Dr. SK Chaturvedi, Dr. SR represented by quotes and scores on four-point Likert scale. Based on Chandra analyses, significant differences with respect to years of education and neuropsychological parameters between the optimal and sub-optimal 63. Maternal mental health promotion- Efficacy of training outcome group was noted. programme among ANMs. Investigators: Dr. Prabha Chandra, Dr. Ramachandra, Dr. Geetha Desai, Mrs. P 60. Cytokine changes and postpartum psychosis a comparative Vijayalakshmi (Funding by ICMR) study. Dr. Gopinath S. Guides: Dr. Harish T, Dr. Ritamani, Dr. Prabha S Chandra Psychiatric Rehabilitation The study aimed at assessing the cytokine changes associated with postpartum psychosis. It was based on the hypothesis that there 1. A naturalistic study of clinical and socio-demographic could be significant immune system dysregulation in a woman with characteristics of patients attending psychiatric rehabilitation first episode postpartum psychosis. The study included 20 cases services for rehabilitation. Investigators: Dr. Sivakumar T, (first episode postpartum psychosis (PPP) with onset less than Dr. Chaturvedi SK, Dr. Thirthalli J, Dr. Nirmala BP, Dr. six weeks of childbirth) and three control groups [Acute transient Bhola P, Dr. Desai G, Dr. Gandhi S, Dr. Kumar CN, Dr. polymorphic psychosis without schizophrenic symptoms (ATPP), Waghmare A, Dr. Udgiri S Healthy postpartum mothers (HPP) and healthy non postpartum women (HNPP)] with a sample size of 20 in each group. After Assessment of factors affecting psychiatric rehabilitation is obtaining written informed consent, blood sample was collected to necessary to plan services and fame policies conducive to recovery separate peripheral blood mononuclear cell suspensions (PBMCs), of persons with psychiatric disorders. There is a paucity of studies which were run through commercial Cytokine Bead Array (CBA) kit examining factors affecting psychiatric rehabilitation in the to measure the levels of various cytokines/chemokines in the serum Indian setup. NIMHANS runs a unique psychiatric rehabilitation samples using flow cytometry. The increase in pro-inflammatory services for patients with psychiatric disorders. The investigators cytokines, IL-6 and IL-8 in the PPP case group appeared like a would study the clinical and socio-demographic profile of physiological event in the immediate post-partum period which patients attending psychiatric rehabilitation services and factors may possibly act as a trigger for PPP in vulnerable women. When influencing rehabilitation. The study would help in the process compared to HPP control group, PPP case group had statistically of understanding rehabilitation needs in persons with psychiatric significant increase of pro-inflammatory cytokine IL-17A (p = 0.03) disorders and factors influencing rehabilitation in the setup. The and increased, but not statistically significant chemokine monocyte services offered can be tuned to address felt needs and barriers
214 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 interfering with successful rehabilitation. The experience can help patients in both rTMS groups with no significant difference between make policies and programs which can be used across the country. true and sham rTMS. This will also help in reintegration of patients with psychiatric disability with mainstream society. 3. Mental health stigma and discrimination in the Indian workplace. Investigators: Dr. SK Chaturvedi, Dr. Srikala 2. Augmentation of cognitive remediation in schizophrenia Bharath, Dr. Poornima Bhola, Mr. Adam Joseph (Fulbright with transcranial magnetic stimulation: A randomized scholar) (Funding by Fulbright-Nehru Research Scholarship) controlled trial. Investigators: Dr. Jagadisha Thirthalli, Dr. Santosh K Chaturvedi, Dr. BN Gangadhar, Dr. C Naveen This mixed-methods inductive study aims to identify the key factors Kumar, Dr. A Shyamsundar, Dr. Keshav Kumar, Dr. Jitender in determining decisions about disclosure of a mental illness in the Saini [Funding by DST – Technology Innovation for workplace. It seeks to examine stigmatization experiences in the Disabled and Elderly (TIDE)] workplace and their relationship to work performance, social barriers to gainful employment and advancement in work settings. In addition, it will explore factors that moderate mental health discrimination in occupational settings. Interviews will be conducted with employees who are currently receiving treatment for mental illness for at least one year. The data collection is ongoing.
4. Explanatory models of mental illness among caregivers of mentally ill referred to rehabilitation services. Investigators: Dr. Poornima Bhola, Dr. Hesi Herbert, Dr. Devvarta Kumar, Dr. Sailaxmi Gandhi, Dr. SK Chaturvedi
This project aims to study the explanatory models of mental illness among caregivers of individuals with psychiatric disorders seeking treatment at a tertiary care neuropsychiatric hospital. The objectives are to explore the explanatory models of care givers of mentally ill and to study the relationship with socio-demographic variables and select clinical variables. The sample will consist of 60 caregivers of inpatients or outpatients, with a psychiatric diagnosis referred to Psychiatric MagPro TMS equipment being used with Brainsightneuronavigation equipment Rehabilitation Services. The study is exploratory in nature with a single group and purposive sampling. The tools used for assessment Cognitive deficits are disabling symptoms of schizophrenia. are a Socio Demographic Data Sheet and Barts Explanatory Model Pharmacological treatment has shown little promise in treating Inventory (Rudell, 2005). The study is in pilot phase. these symptoms. There is evidence for the usefulness of cognitive remediation therapy (CRT) in alleviating these symptoms. 5. Work performance of patients attending psychiatric However, the duration of treatment, which typically lasts for several rehabilitation services for rehabilitation. Investigators: Dr. months, is prohibitive for its wider use. Repetitive Transcranial Sailaxmi Gandhi, Dr. Chaturvedi SK, Dr. Sivakumar T, Dr. magnetic stimulation (rTMS), a non-invasive brain stimulation Nirmala BP technique, is known to influence neuroplasticity. With fast rTMS there is excitation in the underlying brain. Whether combining A pre-experimental research design and non-probability purposive CRT with rTMS would enhance the efficacy of CRT and reduce its sampling technique both gender patients (n=39) with schizophrenia duration is not explored. In this project, the investigators explored (PwS) and availing psychiatric rehabilitation services (PRS) for this by comparing the efficacy of CRT with rTMS – patients were more than a month were invited to participate in this study. Ethical randomly assigned to receive CRT along with either true or sham clearance was obtained from the institute review board. Analysis rTMS daily for 18 sessions and weekly for 3 months thereafter. They with descriptive statistics, paired t test and McNemarχ2 test revealed examined their cognitive functions, symptoms and social functions that there were 26 male and 13 female patients most of whom (n = using standardized tools. They have examined the same in a group 36) had paranoid schizophrenia, in the age group 17 – 55 yrs. and of patients who refused to take part in the trial as treatment-as-usual availing PRS for 6 months. Mean duration. Most of them (39%) group. Preliminary analysis shows that there has been significant worked in the computer section. While work performance improved improvement in cognitive and socio-occupational functioning of significantly (t = -2.735, p = .009, df = 38), global functioning
National Institute of Mental Health and Neuro Sciences 215 Annual Report 2015-2016 also improved significantly (t = -4.929, p = 0.001, df = 38); there Psychiatric Social Work was significant correlation (rho = 0.770, p = 0.001) between work performance and global functioning of the PwS. McNemarχ2 test revealed that 20 PwS did not show any changes in global 1. Testing of self-help yoga manual for Indian caregivers functioning, 18 improved and one worsened. Rehabilitation should of persons with schizophrenia living in the community. commence from the time of diagnosis of mental illness. Mental Investigators: Dr. Aarti Jaganathan, Dr. Md. Ameer Hamza health nurses need to encourage PwS to engage in activities/work of (Funding by ICMR) their choice as the add-on benefits will help them recover with the illness. Future randomized control trials can enhance the quality 2. Psychosocial care for children infected with HIV/AIDS. and aid in generalization of the findings. Investigators: Dr. Vranda MN, Dr. D Subbukrishan, Dr. Jayashree Ramakrishna 6. Community based rehabilitation for persons with severe mental illness in a rural area of South India. Investigators: The research aims towards developing and standardizing Dr. T Sivakumar, Dr. Jagadisha Thirthalli, Dr. C Naveen comprehensive psychosocial care manual for Children and Adolescents Kumar (Funding by NIMHANS intramural research grant) Infected with HIV/AIDS. As part of the project, need assessment has been completed with children infected with HIV, their parents, World Health Organization (WHO) promotes CBR as a strategy to specialists of ART centres, specialists of ART centres, policymakers, improve access to rehabilitation services for Persons with Disabilities counselors, community care providers and NGOs staffs. Currently the (PwD) in LAMICs. WHO has developed a CBR matrix which chapters for the manual have been finalized. Once the manual is ready, consists of five key components: health, education, livelihood, social it will be given to experts for validation and later it will be field tested and empowerment. The CBR programme can select components and with counselors, community care providers who work with children elements in CBR matrix which best meet their local needs, priorities and adolescents infected with HIV/AIDS at NIMHANS, Bengaluru. and resources. The CBR guidelines are relevant to all PwD including persons with mental illness. 3. Psychosocial intervention in motor neuron disease. Investigators: Dr. A Nalini, Dr Prakashi Rajaram, Dr. Priya In partnership with Association of people with disability (APD), Treesa Thomas (Funding by ICMR) the feasibility of implementing a CBR project for persons with severe mental illness (SMI) with existing network of community and Neuromuscular Disorders constitute a major category of non- government systems is being studied at Jagaluru Taluk, Davangere communicable disorders contributing to significant disability and district. family burden and pose a threat to quality of life of the affected individual and family. The efforts for a cure for these disorders are 7. Student expectation and feedback regarding teaching/ on. In this scenario, current project looks into the lived experience of training programme in psychiatric rehabilitation in persons affected with MND/ALS and their caregivers in the milieu Psychiatric Rehabilitation Services, NIMHANS. specific to the Indian culture, and evolve a feasible intervention plan Investigators: Dr. T Sivakumar, Dr. SK Chaturvedi, Dr. to address the psychosocial issues. This would contribute towards Jagadisha Thirthalli, Dr. Devvarta Kumar, Dr. Poornima promotion of individual well-being and optimization of quality of life Bhola, Dr. Sailaxmi Gandhi, Dr. Aarti Jagannathan, Dr. of the individuals with MND and their families. Krishna Prasad, Dr. Hareesh Angothu, Dr. Abhishek Pathak, Dr.James JW 4. Partners in care – Experiences and needs of spouses of persons with obsessive compulsive disorder. Investigators: Psychiatric Rehabilitation Services has evolved a unique teaching Dr. Ameer Hamza, Dr. A Shyam Sundar programme over the last few years. The teaching/training programme consists of clinical rounds, didactic lectures, seminars, case conferences, Obsessive compulsive disorder is a common and disabling mental research forum, debates, book reviews, documentary reviews, disorder that involves a pattern of repetitive intrusive thoughts or caregivers programs, NGO visits, family recreation activity, and impulses that evoke fear and distress and excessive avoidance with volunteers programme. The PRS team has been collecting informal compulsive rituals that can be covert mental acts or overt behaviours feedback and fine tuning the teaching programme. In the proposed which are performed to reduce the distress. Though OCD is typically study, the investigators would formally collect student expectations considered an individual phenomenon, the effects are not limited from the teaching/training programme in psychiatric rehabilitation at to the individual with disorder alone. Instead, affected individual’s the beginning of the posting. After the end of posting, feedback would environment can both impact and be impacted by the illness. The be collected regarding teaching/training in Psychiatric Rehabilitation. response of the spouse may play a significant role in the course and
216 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 outcome of the disorder, quality of life of individuals involved and BP Nirmala, Dr. N Krishna Reddy, Dr. Md. Ameer Hamza, can impair family functioning too. The current study would try to Dr. H Uma, Dr. Roopesh, Dr. John Vijaya Sagar (Funding by understand the experiences of spouses of persons with OCD and their Karnataka State Integrated Child Protection Society) accommodation in the maintaining OCD phenomenon. As part of this project, psycho-social interventions are being provided 5. Sexuality and reproductive health of adolescents with to children from government children homes and those who come for disabilities: An intervention study. Investigators: Dr. N care and protection through Child Welfare Committee. Preventive Janardhana , Dr. D Muralidhar, Dr. Ameer Hamza, Dr. John and promotive mental health activities are being carried out in the Vijay Sagar, Dr. H Uma (Funding by ICMR) institutions concerned. Children in need of curative treatment are being referred to Child and Adolescent Psychiatry OPD. Supervision The Sexual and Reproductive Health (SRH) needs of Adolescents and handholding support is also being provided to counselors at with Disabilities (AWD) are neglected and often have been imposed government children homes. for sterilization and forced abortion. Persons with Disabilities (PWD) have barriers to information and services due to the ignorance and 9. Family perspectives on romantic relationship among attitudes of society and individuals. Most of the existing policies and adolescents girls under care and protection of child welfare programmes focus on prevention of pregnancy. The present study committee. Investigators: Dr. N Janardhana, Dr. BP Nirmala focuses on understanding their needs associated with sexuality and reproductive health and developing and testing the efficacy of need The objectives of this project are to (a) understand the socio- based intervention programme for the same. demographic and family profile of the family members of adolescents in relationship (b) understand the family members’ opinion 6. Identification of psycho social needs and rehabilitation towards romantic relationship among adolescent girls (c) study of survivors of Child Sexual Abuse. Investigators: Dr. N the expectations among family members from adolescent girls in Janardhana , Dr. D Muralidhar, Dr. Vrunda , Dr. John Vijay romantic relationship understand the factors associated with family Sagar, Dr. H Uma (Funding by ICMR) members accepting/rejecting adolescent girls in romantic relationship (d) understand the strategies used by family members to address the The study aims at identifying psycho social needs and available issues associated with romantic relationship among adolescent girls. mechanisms of rehabilitation for victims of child sexual abuse The research study would help in developing explanatory model and recommending strategies and intervention programmes for for family members regarding care and protection issues among addressing the same. The study would help in understanding the risks adolescent girls. Descriptive research design will be used for the and protective factors among survivors of CSA and existing policies study with mixed methods, both qualitative and quantitative. Family and programmes for rehabilitation. Standard operating procedures members of adolescent girls under care and protection of CWC will along with a few assessment tools and guidelines for mental health be approached for their participation in the study. interventions would be adopted for the study. 10. Development and standardization of a scale to measure 7. Capacity building training programme for the newly psychosocial wellbeing of children. Investigators: Dr. Kavita recruited JJB and CWC members of the state of Karnataka. Jangam, Dr. K Sekar, Dr. E Aravind Raj, Dr. Marimuthu Investigators: Dr. N Janardhana, Dr. D Muralidhar, Dr. K (Funding by ICSSR, New Delhi) Sekar, Dr. R Parthasarathy, Dr. Shekhar P Seshadri (Funding by Karnataka State Integrated Child Protection Society) This ICSSR funded project intends to develop and standardize a comprehensive tool to assess the psychosocial wellbeing of children The main aim of the project, funded by Karnataka State Integrated between the age 8 and 13 years. The scale will be applicable for children Child Protection Society, Dept. of Women and Child Development, from varied circumstances. At present, a core group committee Govt. of Karnataka, is to conduct capacity building programmes for the has defined concepts and domains for the scale. The domains and newly recruited JJB and CWC Members of the Karnataka State. During subdomains are being validated by experts in the field. Based on the the year, various training modules were prepared by the research team finalized domains, items will be constructed and subjected to further and the same were field tested. A total of eight training programmes statistical procedures. were conducted, in which 220 JJB and CWC members were trained. 11. Prevention of youth suicide: Development of a comprehensive 8. Psychosocial interventions for children in difficult youth suicide prevention model for school teachers. circumstances under care and protection of Child Welfare Investigators: Dr. Vranda MN, Dr. John Vijay Sagar, Dr. KS Committee Bangalore. Investigators: Dr N Janardhana, Dr. Meena (Funding by ICMR)
National Institute of Mental Health and Neuro Sciences 217 Annual Report 2015-2016
Suicide is one of the major causes of death among adolescents Adolescents account for more than one-fifth of the world’s population. worldwide and evidence suggests that the number of adolescent’s Adolescence is a period of stress and storm that makes them to face committing suicide has drastically increased over the years. Given many challenges in their life. Many research studies found that children the alarming increase in rate of suicide, preventing youth suicide has of parents with alcohol dependence syndrome tend to have significant become an issue of paramount importance with the focus on primary bio-psycho-social issues in their life. The present study is assessing home prevention. Most of the suicide among the youth can be preventable environment, psychological health and psychosocial competencies of with early identification and intervention by the school staffs especially adolescent children of parents with alcohol dependence syndrome. The teachers as they have the greatest access to the students over the findings of the present study would enable the social work profession longest period of time where students spend one third of their day in to understand the associated risk factors and to initiate the process of schools. Teacher’s role in identifying and assisting high risk students providing appropriate psycho social interventions. depends on their ability to recognize and respond appropriately to the situation. The current study directed towards understanding the 15. School based social work intervention for healthy lifestyle knowledge, attitude and training needs of teachers in prevention of of adolescents. Mr. Soyuz John. Guides: Dr. R Dhanasekara suicide and also preparing a comprehensive youth suicide prevention Pandian, Dr. E Aravind Raj (Funding by UGC – JRF) model and guidelines for school teachers. Adolescence is a period of vulnerability. Health related behaviours 12. Development and evaluation of a psychosocial intervention during this period are going to determine the current and future health for women with substance dependence. Ms. Reni Thomas. of this group. Health cognition is one of the factors affecting the Guides: Dr. R Dhanasekara Pandian, Dr. Pratima Murthy health related behaviours. So the current research aims at developing an intervention package and testing its effectiveness on the health The study indicates that clinical services for addiction treatment cognition of adolescents in promoting their health related behaviours addressing gender specific issues are more effective for women than traditional programs, originally designed for men. However, there 16. Impact of psychiatric social work intervention on expressed are very few studies from India which assess the treatment needs emotion and knowledge among caregivers of persons with and concerns of women with SUDs. Current study aims to develop schizophrenia. Mr. Kannappa Setty. Guides: Dr. Janardhana and evaluate a psychosocial intervention for women with substance N, Dr. Marimuthu, Dr. Suresh BM dependence by adopting a quasi-experimental research design. Researcher has recruited 33 samples from NIMHANS by using Schizophrenia is a chronic mental disorder that leads to various consecutive sampling with objectives to explore the psychosocial risk psycho-social problems in family members. In addition, the family factors, treatment needs and concerns, develop and evaluate the need environment also causes several psycho-social problems, such as based psychosocial intervention for women with substance dependence. high expressed emotion. Aim of the present study is to evaluate the efficacy of psychiatric social work intervention on expressed emotion 13. Intensive case management for persons with severe alcohol and knowledge in caregivers of persons with Schizophrenia. Ten days dependence: a feasibility study. Mr. Arthur Julian Anthony of PSW intervention has been developed and validated. Intervention Joseph. Guides: Dr. R Dhanasekara Pandian, Dr. Pratima programme was given to 80 caregivers of persons with schizophrenia. Murthy Findings show that there is a significant change in the knowledge level of the caregivers and reduction in high expressed emotion. It can The aim of this research is to develop a need based psycho social be concluded that the standardized PSW intervention found to be intervention package and to examine the feasibility of Intensive Case acceptable among the caregivers of persons with schizophrenia in India. management as an adjunct to routine treatment for persons with severe alcohol dependence (i.e. Delirium Tremens, DT). Literature on psycho 17. Experiences and needs of adolescent children living with a social interventions for persons with DT in the Indian scenario is parent with mental illness. Ms. Divya Ballal. Guides: Dr. N scarce. This study will add to the empirical mental health literature in Janardhana, Dr. Jayshree Ramakrishna, Dr. Prabha Chandra developing a framework for mental health professionals while providing (Funding by UGC– JRF) comprehensive mental health service delivery to this vulnerable population along with their care givers for promoting a better quality of life. Children of parents with mental illness have been identified as a vulnerable population. This study aims to investigate the subjective experiences and 14. Home environment, psychological health and psychosocial needs of adolescent children, aged 15 – 19 years, living with a parent competencies of adolescent children of parents with alcohol with a psychotic illness, using a qualitative methodology. The proposed dependence syndrome. Mr. Mutharaju A. Guides: Dr. R outcome of the study is a theoretical perspective to understand the Dhanasekara Pandian, Dr. Vivek Benegal subjective experiences of adolescent children living with a parent with
218 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 mental illness, a checklist to identify their experiences, and a theoretical and qualitative, will be adopted for the study. In the quantitative phase, intervention, based on the identified needs. psycho-social profile of the participants will be studied with regard to their attachment styles, temperament, attitudes and values on sexuality, 18. Efficacy of group intervention module for adolescent girls family functioning. Qualitative part of the study focuses on adolescent on self-awareness. Ms. Jasmine Mary John. Guides: Dr. N girl’s perception about romantic relationship, attribution, expectations, Janardhana, Dr. HR Nagendra (Funding by ICMR-JRF) cognitive and emotional processes of romantic relationship and their views on factors associated with care and protection issues. Research Self-awareness is having a clear perception of one’s personality, including studies on adolescent romantic relationships showed that they have strengths, weaknesses, thoughts, beliefs, motivation and emotions. The significant impact at individual and family levels and especially on aim of the study is to develop a mental health promotion module for mental health of adolescents. Hence, the study provides understanding adolescent girls on self-awareness and test its efficacy among them. about psycho social aspects adolescent girls in romantic involvement The study adopts experimental research design with control and with regard to their perspectives about romantic relationship. This experimental groups. A module has been developed based on body helps in developing culture specific explanatory model of romantic focused meditation, and using mental health promotional aspects. relationships. The present study has implications for both therapeutic Intervention has been provided to the school-going adolescents and interventions for this group and further research in the area. post-assessment has to be carried out to test its efficacy. 21. Efficacy of treatment adherence enhancement interventions 19. Life Experiences, Quality of Life, Wellbeing and Future for persons with bipolar affective disorder. Mr. Ragesh G. Strategies of Older Transgender Individuals. Ms. Alphonsa Guides: Dr. Md Ameer Hamza, Dr. Santosh K Chaturvedi George. Guides: Dr. N Janardhana, Dr. D Muralidhar (Funding by ICMR- JRF) 22. Efficacy of family centered psychiatric social work interventions for persons with first episode psychosis: A Transgender individuals face a great deal of stigma and discrimination randomized controlled trial. Ms. Udgiri Swarupa Mohan. in their day to day life, in all fields of their personal as well as Guides: Dr. BP Nirmala, Dr. JagadishaThirthalli social living, such as family life, education, employment, human rights, and so many of the kind. The literature mostly speaks about 23. Efficacy of psychosocial intervention with siblings of the transgender individuals in general and it covers transgender persons with Schizophrenia. Mr. Amaresha C. Guides: Dr. D individuals of all age groups. In-depth analysis of the literature Muralidhar, Dr. DK Subbakrishna concerning the older transgender individuals is more or less absent, especially in the indigenous studies. The aim and objectives of the Schizophrenia is a complex disorder characterized by positive study were to find out the socio demographic profile, life experiences, symptoms such as hallucinations and delusions; negative symptoms factors associated with acceptance or non-acceptance by family/ such as affective flattening, alogia, avolition, anhedonia and apathy, and members or partners, coping measures, quality of life, well-being, and cognitive deficits. The chronicity and the other illness related effects future strategies of older transgender individuals who are 40 years of of schizophrenia pose a significant burden on persons suffering from age and above, and to develop a social work intervention model for the this illness as well as their families. Literature shows that the family transgender community based on the experiences of the experienced caregivers in India play an important role in the treatment and recovery transgender individuals. The analysis of the quantitative variable of the person with severe mental illness, since a majority of the patients showed a moderate to good level of quality of life and wellbeing of live with their families. Though schizophrenia affects the whole family, the respondents. The qualitative results were analyzed using thematic research predominantly identifies the issues of parents and spouses of analysis procedures. The results were explained under themes and sub the patients and a major proportion of participants in psychosocial themes, according to the objectives and the variables. interventions on caregivers are from these two groups. The studies on siblings of persons with schizophrenia (SOPS) show that they are also 20. Psychosocial profile of adolescent girls in romantic relationship negatively affected by the illness and have suggested that there is a need under care and protection of Child Welfare Committee. Ms. for psychosocial. Some of the researchers have argued that SOPS are Manjula B. Guides: Dr. N Janardhana, Dr. BP Nirmala also important members in the treatment during their siblings’ illness trajectory especially when other caregivers are not. In this context it The aim of the project is to study the psycho social profile adolescent is also necessary to acknowledge their contributions to the recovery of girls in romantic relationship under care and protection of CWC. It their ill siblings and address their needs. In addition several reviews is also intended to develop a theoretical framework for intervention have established that SOPS are at a high-risk of mental illness. Thus, of adolescent girls in romantic relationship under care and protection. understanding their specific needs and developing the psychosocial Descriptive research design with mixed methods, both quantitative interventions to meet their issues is the need of the hour.
National Institute of Mental Health and Neuro Sciences 219 Annual Report 2015-2016
24. Personal meaning of recovery among persons with Severe mental disorders like bipolar affective disorder, schizophrenia, Schizophrenia. Ms. Shari Tess Mathew. Guides: Dr. BP and major depressive disorder have higher risk of metabolic syndrome Nirmala, Dr. K John Vijay Sagar (Funding by UGC- JRF) (also known as syndrome X) and that leads to excessive mortality of these patients mainly due to physical illness. Many studies have found There is little understanding of service users’ conceptions of recovery from that metabolic syndrome is two-three times more common in persons mental illnesses in the Indian context. An understanding of meanings of with bipolar affective disorder, schizophrenia, and major depressive recovery from client’s perspective may help with the development and disorder as compared to general population. In the recent years, the evaluation of interventions that address the concerns of service users and importance of physical health in persons with severe mental illness which may enhance the process of recovery. This study aims to examine has become increasingly recognized by the medical community. Many the personal descriptions of recovery among individuals treated for studies have found that lifestyle interventions like weight management Schizophrenia using a mixed methodology approach. by physical exercise, healthy dietary practices, smoking cessation, etc., can bolster effective management of metabolic syndromes. For this 25. Efficacy of Psychiatric Social Work Intervention as Add-on study, a lifestyle intervention package will be developed on the basis Measure in Enhancing Insight among Persons with First of literature review and content validated through discussions with Episode Schizophrenia. Mr. Boban Joseph. Guides: Dr. D experts from different fields. Baseline assessment will be done before Muralidhar, Dr. Shivarama Varambally, Dr. Devvarta Kumar and after intervention. Two post assessments will be done after one month and three months respectively. Research estimated that majority of persons affected with schizophrenia have poor insight into their illness. Better insight helps in the recovery 28. Development and standardization of strengths based scale of person from schizophrenia. Psychiatric Social workers are involved for persons with depression. Ms. Manasi Oza. Guides: Dr. with person with schizophrenia and their caregivers from their first Sekar, Dr. Marimuthu contact with mental health setting. This study was based on a classical experimental design with control and treatment groups and rater Globally, more than 350 million people have depression, a mental blinding. Interventions were targeted on person with First Episode disorder that prevents people from functioning well. WHO estimates Schizophrenia and their Caregivers. Study protocol is registered with suggest that depression is common in all regions of the world. A recent CTRI- India. This study is expected to be complete by 2018. study supported by WHO has revealed that around 5% of people in the community had depression during the last year. 26. Effectiveness of Student Enrichment Programme by teachers for rural school children. Mr. Patrick Jude L. Guides: Dr. K There are various psychosocial treatments used by mental health Sekar, Dr. E Aravind Raj (Funding by UGC- JRF) professionals such as psychiatrists, psychiatric social workers and psychologists for individuals with depression. One of the models of The study aims at building the capacity of teachers in understanding treatment by social workers that is gaining much deserved popularity the components of a comprehensive student enrichment programme is the strengths based approach. This approach has been used by social which would include the current needs of rural school children along workers to treat various kinds of mental disorders. The approach with the previously identified needs like physical and mental health, assumes (as has been discussed in the earlier part of this chapter) exam preparation, study habits, role of parents and teachers, etc. The that every individual has strengths that need to be tapped into if the same would be eventually rendered to the students of classes V to VII individual is to be helped. While many social workers, especially in the through two weekly sessions involving simple activities like free listing, west, have started using this approach and have been successful, it is group discussion, quiz, role plays and so on. Adequate sessions would also true that there is the lack of a tool that can measure the strengths be given to the teachers to gain mastery over the programme and this of persons suffering from depression. Thus, this study is one of the is done mainly to ensure the sustainability of the intervention. To first attempts at trying to develop a tool that may help in tapping the establish the effectiveness of the programme, the knowledge, attitude strengths of persons with depression, so that the treatment based on and practice of the teachers and the students regarding the programme the strengths approach may gain more coherence. will be evaluated using structured tools before and after the intervention and three months post intervention. The training would involve 29. Development of psycho-social intervention for suicide participatory methodology comprising role plays, group discussions, prevention among transgender persons. Mr. Virupaksha. modelling, etc., helping the participants to internalize the skills. Guide: Dr. D Muralidhar (Funding by UGC- JRF)
27. Effectiveness of lifestyle modification for metabolic Suicide rate and suicidal tendencies among transgender community syndrome in persons with severe mental illness. Mr. Vinit has been reported to be high compared to general population. Hence, Kumar Singh. Guides: Dr. D Muralidhar, Dr. Muralidharan there is a dire need for the mental health professionals to study the K (Funding by UGC-JRF) phenomenon thoroughly and draw appropriate interventions. The
220 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 study will be conducted in the metropolitan city, Bengaluru with the 2. A pilot, nonrandomized, open label, prospective comparison help of non-government organizations working for the transgender of the effects of penfluridol andrisperidone on cardiac community. electrophysiological indices in patients with schizophrenia and related disorders. Investigators: Dr. Chittaranjan 30. Influence of family factors on mental health and functioning Andrade, Dr. TN Sathyaprabha, Dr. Preethi Sinha of adolescents receiving in-patient care. Ms. Sabana Abobaker. Guides: Dr. Kavita V Jangam, Dr. K John Vijay This study seeks to explore the effects of penfluridol on the ECG, Sagar (Funding by UGC MANF) with risperidone as a quasi-control. Recent regulatory and clinical concerns have brought sharp focus on antipsychotic drug induced QT The main objective of the study is to explore certain family factors prolongation, torsade de pointe and sudden cardiac death. Despite (family environment, family violence, parenting practice, and parental availability of the drug since the 1970s, there are no published studies stress and life events) and its association with mental health status describing the influence of penfluridol on cardiac electrophysiology and functioning of adolescents who are receiving inpatient care from in humans, especially the effect of the drug on the QTc interval in Child and Adolescent Psychiatry Department, NIMHANS. The the electrocardiogram (ECG). The QT prolongation is risk factor for naturalistic descriptive research design will be used and sample will ventricular arrhythmia, and torsade de pointes, which may result in be collected using consecutive sampling method with a minimum sudden death. This study seeks to explore the effects of penfluridol of 100 samples. The process of the study would involve assessments on the ECG. during admission, discharge and two months after discharge. This is basically to know how the family factors influence/impact adolescents’ The primary objective of the study is to determine the effects of mental health and functioning over a period of time. The data will be penfluridol on cardiac electrophysiological indices in patients with collected from both adolescents and their parents. schizophrenia and related disorders, comparison with risperidone. The methodology will involve a pilot, nonrandomized, non-blind, 31. Barriers and facilitators in functionality of persons with prospective, parallel group comparison of the ECG changes associated chronic mental illness. Ms. Fahim Ul Hassan. Guides: Dr. K with penfluridol and risperidone (a standard second generation Sekar, Dr. E Aravind Raj (Funding by UGC JRF) antipsychotic drug) treatment in schizophrenia (and related disorder) patients. The population is defined as all male patients aged 18-50 The aim of the study is to understand the barriers that increase the years who have been diagnosed with schizophrenia or related disorders. disability and facilitators that improve functionality as well as levels Nine cases and 23 controls have been recruited for the study. of satisfaction of persons with chronic mental illness in families, rehabilitation centres and the tertiary care hospital. The study 3. Electroconvulsive seizure-induced neuroplasticity changes would help to identify contributing factors for the functionality or in the rat brain. Dr. Ravi Prabhakar Hegde. Guides: Dr. disability and satisfaction of care, which at large would be beneficial in Chittaranjan Andrade, Dr. B.K. Chandrasekhar Sagar designing better rehabilitation programs and facilities, which in turn (Funding by ICMR) would improve functionality of persons with chronic mental illness and decrease Disability Adjusted Life Years (DALY) Neuroplasticity changes have been proposed as mechanism of action of electroconvulsive therapy (ECT). Electroconvulsive shocks (ECS) 32. Psychosocial therapeutic intervention with parents of and antidepressants have shown to induce nerve cell proliferation in children and adolescents referred to family psychiatry the hippocampus, the increase in the number of neurons is correlated centre. Mrs. Tania Roy. Guides: Dr. A Thirumoorthy, Dr. R with the number of ECS administered. ECT is an important Parthasarathy (Funding by UGC JRF) treatment modality for patients with major depression, schizophrenia and mania. In order to obtain maximum effectiveness with minimum 33. Social case work amongst persons with depressive disorders side effects, ECT has to be dosed appropriately. Understanding dose- – A strengths perspective. Mr. Sudeep Joseph. Guides: Dr. A dependent neuroplasticity effects of ECS could guide future research Thirumoorthy, Dr. Sekar and practice on ECT stimulus dosing. Therefore this study proposes to examine dose dependent ECT induced neuroplasticity using an animal model. Brain from control and treated group were removed, Psychopharmacology fixed in paraformaldehyde and processed for Golgi method. Using this method the dendritic arborisation of both control and treated group 1. Multimodal imaging to visualize neuronal plasticity changes were analyzed. Hippocampus of the treated group showed many newly augmented by bilateral tDCS in subacute stroke patients. formed dendritic sprouts when compared to control group. Numbers Investigators: Dr. C Andrade, Dr. Anupam Gupta, Dr. GB of synapse were increased in the high dose and repeated ECT treated Kulkarni, Dr. John P John (Funding by ICMR) animals. These increased synapses were found to be excitatory in nature.
National Institute of Mental Health and Neuro Sciences 221 Annual Report 2015-2016
4. Alteration of heart rate variability and cardiac electrophysiological recreation, shopping, visiting friends, etc. They felt that greater variables in a rodent model of brain stimulation.Mr. Nagendra awareness regarding aphasia will help enhance use of communication Madan Singh. Guides: Dr. Chittaranjan Andrade, Dr. Jagadisha strategies by the communication partner outside home settings. T (Funding by ICMR fellowship) 3. A prospective, randomized, double blind, sham-controlled 5. A randomized, double blind, sham controlled study of study of the effect of transcranial direct current stimulation transcranial direct current stimulation (tDCS) as an (tDCS) on speech-language function in early post stroke augmentation intervention for the attenuation of motor patients. Investigators: Dr. Vandana VP, Dr. Andrade C, Dr. deficits in patients with acute ischemic stroke. Ms. Ekta Jayaram, M, Dr. Gupta A, Dr. Kulkarni G Francina Pinto, Dr. Chittaranjan Andrade, Dr. Anupam Gupta, Dr. Girish Kulkarni (Funding by DST fellowship) A number of research studies employing tDCS have reported lasting improvement in specific language functions in patients with chronic post-stroke aphasia. The present project is a pilot study to see the Speech Pathology and Audiology effect of ipsilateral and contralateral tDCS on speech-language function in subacute ischemic stroke. The study aims to evaluate the 1. Effect of deep brain stimulation on speech of patients with pre- and persistent effects of tDCS (2 weeks after tDCS) on speech- Parkinson’s disease (PD). Investigators: Dr. VP Vandana, Dr. language function. Data collection is ongoing. M Jayaram, Dr. Pal PK, Dr. S Dwarakanath, Dr. Y Ravi. 4. Articulatory kinematics in patients with Amyotrophic Deep brain stimulation (DBS) has been reported to be successful Lateral Sclerosis (ALS). Investigator: Dr. BK. Yamini in relieving the core motor symptoms of Parkinson’s disease (PD) (Funding by DBT, New Delhi) and motor fluctuations in the more advanced stages of the disease. However, data on the effects of DBS on speech performance are A preliminary analysis on speech tasks comparing kinematic variables inconsistent. The aim of the study is to analyze the pre- and post- of ALS and healthy controls showed that the parameters of velocity DBS speech characteristics of patients with PD using acoustic and and acceleration of the mobile articulators were significantly higher in perceptual tasks. Data collection is ongoing. the controls than ALS.
2. Supporting caregivers of persons with aphasia: Comparison 5. Acoustic analysis, perceptual judgment and algorithm based of Speech-Language service provision and caregiver demand. automatic analysis of vocal tremor. Investigators: Dr. BK Investigators: Dr. VP Vandana, Dr. M Jayaram Yamini, Dr. Shivashankar, Dr. Pramod Kumar Pal
The number of persons surviving a severe stroke is gradually increasing 6. Acoustic analysis, perceptual judgement and algorithm based thanks to improved stroke care. After the acute phase, stroke survivors automatic analysis of vocal tremor- A retrospective study. often experience severe and persisting impairments like aphasia. After Investigators: Dr. BK Yamini, Dr. Shivashankar, Dr. Pramod discharge from the hospital, close relatives/caregivers provide emotional Kumar Pal support and provide practical care in daily life activities. Supporting partners and children is important in the successful reintegration of persons 7. Development of an alerting device for caretakers of with aphasia in society. The objectives of the study are to (i) investigate cognitively impaired. Investigators: Dr. Pradeep Yuvaraj, Dr. the extent to which partners/caregivers of persons with aphasia find it M Jayaram, Mr. Karthik necessary to be informed, supported and trained by speech and language pathologists to take care of their patient with aphasia (ii) Investigate the 8. Development of an alerting device for individuals with perception of speech-language pathologists regarding the importance of hearing impairment and its efficacy. Investigators: Dr. supporting family members and the extent to which they provide care. Pradeep Yuvaraj, Dr. M Jayaram, Mr. Karthik
The results of the study indicate that approximately 50% of the caregivers stressed the need for written information and contact with Transfusion Medicine & other partners and children of person with aphasia. The SLP group also evaluated the same aspects as important. Apart from these 30% Heamatology of caregivers also stressed on the need for public awareness regarding aphasia, which in turn will help successful reintegration of the person Acute kidney injury and hydroxyl ethyl starch administration (as with aphasia in society. They emphasized the need for reintegration a replacement fluid) in patients undergoing therapeutic plasma in daily activities like work re-entry, attending family functions, exchange – A retrospective analysis. Dr. Akshay Batra, Post-
222 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Doctoral Fellow, Dept. of Transfusion Medicine and Haematology. 9. Efficacy of Ayurvedic treatment for motor weakness due Guide: Dr. M Radhakrishnan, Additional Professor, Dept. of to ischemic stroke – a prospective randomized controlled Neuroanesthesia study.
Hydroxyethyl starch is a commonly used replacement fluid for patients 10. Clinical evaluation of the efficacy of Trayodasanga Guggulu, undergoing plasmapheresis. However, the HES is not used in western Maharashnadi Kwatha and Prasarani Thaila in the countries considering its effect on renal functions. The aim of the study management of Gridhrasi (Sciatica). Investigators: Dr. D is to examine the effect of HES in patients who undergo plasmapheresis Sudhakar, Dr. SK Tiwari for various neurological disorders. Investigators are collecting data of patients who have undergone five sessions of acute therapy of 11. Clinical evaluation of Pathyadi Kwatha in the management plasmapheresis of 10 days duration during the period 1st January to of Ardhavabhedaka (Migrain). Investigators: Dr. BCS Rao, 31st December 2015 (one year) in the Department of Transfusion Dr. GV Ramana, Dr. HK Gupta Medicine. Patients on maintenance therapy were excluded. 12. Clinical evaluation of Kalyanaka Ghrita in the management Ayurveda of Smriti Dourvalya. Investigators: Dr. GV Ramana, Dr. D Sudhakar, Dr. HK Gupta, Dr. Srinibash Sahoo. 1. Clinical evaluation of a comprehensive Ayurvedic intervention in the management of Manodwega (GAD). 13. Clinical evaluation of Panchagavya Ghrita and Jyotishmati Taila in the management of Vishada (Depression). 2. Ayurveda Mobile Health Care Programme under Scheduled Castes Sub Plan (SCSP) 14. A comparative study of Ayurvedic treatment vs Allopathic treatment in patients with moderate to severe dementia 3. Pharmacovigilance Programme. (Smriti bramsa).
4. Clinical evaluation of Brahmi Ghrita and Jyothismati Thaila 15. Effectiveness of the role of Astangalavana and Srikhandasava in the management of Cognitive Deficit (IMR Project) as add-on treatment on Madatyaya (Alcohol Dependence) - An open level clinical trial. 5. Clinical evaluation of Brahma Rasayana in the management of Manasa Mandata (Mental Retardation) – an open clinical 16. Clinical evaluation of Ayurvedic intervention in the Trail. (IMR Project) management of Gridhrisi Vata (Sciatica).
6. Clinical Evaluation of Sarasvata Ghrita in the management 17. Clinical evaluation of Katibasti and Vatari Guggulu in the of Cognitive Deficit (IMR Project) management of Katishoola (Lumbar Spondylosis) – An open clinical trial. 7. Ayurvedic coded drug (AYUSH MANAS) in the management of Manasa Mandata (Mental Retardation). 18. Clinical evaluation of ayurvedic intervention in the management of Manyashoola (Cevical Spondylosis). 8. Efficacy of Manasamitra Vadakam on generalized anxiety disorder: A polysomnographic assessment on sleep 19. Management of refractory epilepsy with Panchagavya Ghrita architecture and EEG power spectra. as add on – A collaborative study with NIMHANS.
R eSEARCH Projects Number of Research Projects Total Projects Total Amount Involved (INR) Total Amount Per Annum (INR) A. Newly Sanctioned Projects i) National 34 259,322,119.00 78,035,666.00 ii) International 4 2,485,934.00 2,115,346.00 TOTAL 38 261,808,053.00 80,151,012.00 B. Ongoing Projects i) National 292 865,488,336.00 313,994,094.00 ii) International 35 77,118,168.00 28,005,264.00 TOTAL 327 942,606,504.00 341,999,358.00 C. Completed & Closed (02) 2 9,915,302.00 9,915,302.00
National Institute of Mental Health and Neuro Sciences 223 Annual Report 2015-2016
National Mental Health Survey 2014–16
Recognising the need for good quality, scientific and reliable across 6 regions of India [North (Punjab and Uttar Pradesh); South information and to strengthen mental health policies and (Tamil Nadu and Kerala); East ( Jharkhand and West Bengal); programmes at national and state levels, the Ministry of Health West (Rajasthan and Gujarat); Central (Madhya Pradesh and and Family Welfare (MOHFW) commissioned NIMHANS to Chhattisgarh) and North-east (Assam and Manipur)]. In each state, undertake a National Mental Health Survey (NMHS) in a nationally the dedicated team of Investigators include both mental health and representative population. The Objectives of NMHS are: public health professionals.
A. Estimate the prevalence and burden of mental health disorders in Based on the experiences of the pilot study undertaken in the district a representative population of India. of Kolar(Public Health Observatory of NIMHANS), a uniform and standardised methodology has been developed and incorporated B. Identify the current treatment gap, health care seeking and as the ‘Master Protocol (what-to-do)’ along with a companion service utilisation patterns, disability status and impact of mental ‘Operational Guidelines documents (how-to-do)’. NIMHANS disorders. Institutional Ethics Committee approved the study protocol.
C. Assess mental health care facilities, resources and systems in the The methodology adopted is a multi-stage, stratified, random cluster surveyed states for planning and strengthening of mental health sampling technique, with random selection based on Probability services Proportionate to Size at each stage; all individuals 18 years and above in the selected households are being interviewed. A sub- A National Technical sample has been included Advisory Group (NTAG) in four states to examine consisting of mental health feasibility of methodology professionals, public health for understanding mental professionals and experts morbidity amongst was constituted and headed adolescents (13 – 17 years). by the Jt. Secy, MoHFW Both quantitative and advised and guided the qualitative methods have conduct of NMHS. A been employed. A set of National expert panel 10 instruments including comprising of methodology Mini International Neuro- experts, statisticians, public Psychiatric Interview health professionals was (M.I.N.I 6.0) has been constituted to advise on the adapted to document mental study methodology. morbidity.
A team being led by Dr G After a rigorous 8 week Gururaj and Dr Mathew training and micro- Varghese as Principal planning effort, field data Investigators, includes collectors undertook door nearly 50 investigators from to door interviews. The NIMHANS, 60 investigators training was participatory from the individual states, and the different methods more than 100 field data included were class room collectors across the states and a large numbers of persons who have sessions, training in the hospital (observation and demonstration contributed to data collection and collation under mental health of interviews), and training in the community (both supervised and systems assessment. The NMHS is being undertaken in 12 states independent) and hands-on training in data collection on tablets.
224 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Information is being captured on handheld devices and strict objective of the SMHSA is to examine the availability of health and protocols have been established for data transfer and management health related resources for mental health activities / programmes with access controlled mechanisms. in the 12 surveyed states and assess the status of mental health services and programmes in the surveyed states through a systems To ensure quality apart from rigorous training, weekly and fortnightly assessment framework. review and problem solving meeting were held both locally and with NIMHANS team. Data received from all states is examined Based on the experience of the mental health systems assessments for errors regularly and feedback provided to the state team during conducted in the District of Kolar, Karnataka state and in the State of fortnightly e-reviews. Tamil Nadu along with review of the WHO-AIMS and the WHO Atlas, and after extensive consultation with different stakeholders, Till 31st March 2016, a total of 30,134 interviews were completed. the tool for data collection under SMHSA was finalised.
At the time of submission of this report, the data collection and other The different sources of data for the SMHSA are census 2011 related activities has been completed and report released on the occasion of documents, national health profile, state PIPs (Programme World Mental Health Day 2016. The report of the NMHS is available at Implementation Plans), documents in the state health departments, http://nimhans.ac.in/national-mental-health-survey-2015-16. State Directorate of Economics and Statistics, State Crime Records Bureau, etc). The data so collated was checked for accuracy and State Mental Health Systems Assessment under NMHS validity during the months of January to March 2016. A set of indicators is being finalised along with a scoring methodology. The State Mental Health Systems Assessment (SMHSA) under the The state level expert group being constituted for this purpose will NMHS is a systematic and comprehensive analysis of components review, deliberate, debate and discuss to reach a consensus on the and sub-components of health systems that cater to the management information provided which will enable the development of the state of mental health problems at the individual state level. The specific level fact sheet.
National Institute of Mental Health and Neuro Sciences 225 Jasmine Mary John Publications
International Journals 9. Ali MK, Bhaskarapillai B, Shivashankar R, Mohan D, Fatmi ZA, Pradeepa R, et al. Socioeconomic status and cardiovascular risk in urban South Asia: The CARRS Study. European Journal 1. Abraham AM, Sudhir PM, Philip M, Bantwal G. Illness of Preventive Cardiology. 2016 Mar 1;23(4):408–19. perceptions and perceived barriers to self-care in patients with type 2 diabetes mellitus: an exploratory study from India. 10. Amaresha AC, Joseph B, Agarwal SM, Narayanaswamy JC, International Journal of Diabetes in Developing Countries. Venkatasubramanian G, Muralidhar D, et al. Assessing the needs 2015 Sep;35(S2):137–44. of siblings of persons with schizophrenia: A qualitative study from India. Asian Journal of Psychiatry. 2015 Oct;17:16–23. 2. Agarwal R, Dhanya R, Parmar L, Vaish A, Sedai A, Periyavan S. A study of the noncompliance of blood banks on safety and 11. Ambigai Rajendran, Sivakumar Gopalakrishnan, Pallavi, L. C., quality parameters in blood donation camps in Bengaluru. Sinu, E. Intervention programmes for child sexual abuse - A Asian Journal of Transfusion Science. 2015;9(1):23. review. International Journal of Current Research. 2015; 7(10): 21266-212688. 3. Agarwal R, Periyavan S, Dhanya R, Parmar L, Sedai A, Ankita K, et al. Complications related to blood donation: A multicenter 12. Ameer H, Suchismita M, Dharma R, N J. Knowledge, Attitude study of the prevalence and influencing factors in voluntary and Behaviour towards Adolescence Sexuality among Social blood donation camps in Karnataka, India. Asian Journal of Work Students of Bangalore City: Impact of TV and Internet. Transfusion Science. 2015;0(0):0. International Contemporary Research Journal in Management and Social Science. 2015; 1(4):148-52. 4. Agarwal RK, Ankita K, Gowda P, Agarwal S, Sabnavis AG, Panthangi R, et al. Managing rare blood group requests - Bombay 13. Ameer Hamza, G Ragesh, Sajitha K. Tracing and Reuniting with Oh phenotype: our experience with www.bombaybloodgroup. Family of Unknown Mentally Ill Persons. International Journal org. Blood Transfus. 2016 Jan;14(1):89–90. of Research and Scientific Innovation. 2015; 2(XII):54-6. 5. Agarwal SM, Bose A, Shivakumar V, Narayanaswamy JC, 14. Anand S, Shivashankar R, Ali MK, Kondal D, Binukumar B, Chhabra H, Kalmady SV, et al. Impact of antipsychotic Montez-Rath ME, Ajay VS, Pradeepa R, Deepa M, Gupta R, medication on transcranial direct current stimulation (tDCS) Mohan V, Narayan KM, Tandon N, Chertow GM, Prabhakaran effects in schizophrenia patients. Psychiatry Research. 2016 D. Prevalence of chronic kidney disease in India and implications Jan;235:97–103. for cardiovascular disease: the Cardiometabolic Risk Reduction in South Asia surveillance study. Kidney Int. 2015 Jul; 88(1):178-85. 6. Agarwal SM, Danivas V, Amaresha AC, Shivakumar V, Kalmady SV, Bose A, et al. Cognitive mapping deficits in 15. Andrade C. A Method for Deciding About the Possible schizophrenia: Evidence from clinical correlates of visuospatial Safety of Modafinil and Armodafinil in Patients with Seizure transformations. Psychiatry Research. 2015 Aug;228(3):304– Disorder: (Clinical and Practical Psychopharmacology). The 11. Journal of Clinical Psychiatry. 2016 Jan 27;e25–8. 7. Agarwal SM, Rajur S, Bose A, Shenoy S, Miriyala S, Shivakumar 16. Andrade C. A Primer on Confidence Intervals in V, et al. Use of transcranial direct current stimulation (tDCS) Psychopharmacology: (Practical Psychopharmacology). The in a woman with behavioral variant fronto-temporal dementia. Journal of Clinical Psychiatry. 2015 Feb 25;e228–31. Asian Journal of Psychiatry. 2016 Feb;21:31–2.
17. Andrade C. Adverse Outcomes Following Serotonin Reuptake 8. Agarwal SM, Venkatasubramanian G. The relevance of Inhibitor Exposure During Pregnancy: (Commentary). The translational neuroscience in psychiatry residency training. Journal of Clinical Psychiatry. 2016 Feb 24;e199–200. Asian Journal of Psychiatry. 2015 Oct;17:131–2.
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18. Andrade C. Anti-inflammatory strategies in the treatment of 29. Andrade C. Sustained-Release, Extended-Release, and Other schizophrenia. Expert Review of Clinical Pharmacology. 2016 Time-Release Formulations in Neuropsychiatry: [Clinical Feb;9(2):161–3. and Practical Psychopharmacology]. The Journal of Clinical Psychiatry. 2015 Aug 26;e995–9. 19. Andrade C. Bioequivalence of Generic Drugs: (Clinical and Practical Psychopharmacology). The Journal of Clinical 30. Andrade C. The Numbers Needed to Treat and Harm (NNT, Psychiatry. 2015 Sep 23;e1130–1. NNH) Statistics: What They Tell Us and What They Do Not: (Practical Psychopharmacology). The Journal of Clinical 20. Andrade C. Bioequivalence of Generic Drugs: A Simple Psychiatry. 2015 Mar 25;e330–3. Explanation for a US Food and Drug Administration Requirement: (Clinical and Practical Psychopharmacology). 31. Andrade C. The Primary Outcome Measure and Its Importance The Journal of Clinical Psychiatry. 2015 Jun 24;e742–4. in Clinical Trials: (Clinical and Practical Psychopharmacology). The Journal of Clinical Psychiatry. 2015 Oct 21;e1320–3. 21. Andrade C. Cost of Treatment as a Placebo Effect in Psychopharmacology: Importance in the Context of Generic 32. Andrade C. Understanding Relative Risk, Odds Ratio, and Drugs: (Clinical and Practical Psychopharmacology). The Related Terms: As Simple as It Can Get: (Clinical and Practical Journal of Clinical Psychiatry. 2015 Apr 22;e534–6. Psychopharmacology). The Journal of Clinical Psychiatry. 2015 Jul 22;e857–61. 22. Andrade C. Delayed Drug Interactions in Psychiatry: Armodafinil and Risperidone as a Potential Case in Point: 33. Andrade C. Use of Acetaminophen (Paracetamol) During (Clinical and Practical Psychopharmacology). The Journal of Pregnancy and the Risk of Attention-Deficit/Hyperactivity Clinical Psychiatry. 2015 Dec 23;1633–4. Disorder in the Offspring: (Clinical and Practical Psychopharmacology). The Journal of Clinical Psychiatry. 2016 23. Andrade C. Examination of Participant Flow in the Mar 23;e312–4. CONSORT Diagram Can Improve the Understanding of the Generalizability of Study Results. The Journal of Clinical 34. Andrade C. Use of Acetaminophen (Paracetamol) During Psychiatry. 2015 Nov 25;e1469–71. Pregnancy and the Risk of Autism Spectrum Disorder in the Offspring: (Clinical and Practical Psychopharmacology). The 24. Andrade C. Intranasal Drug Delivery in Neuropsychiatry: Journal of Clinical Psychiatry. 2016 Feb 24;e152–4. Focus on Intranasal Ketamine for Refractory Depression: (Clinical and Practical Psychopharmacology). The Journal of 35. Andrade C. Zolpidem use as a predictor of Parkinson’s disease. Clinical Psychiatry. 2015 May 27;e628–31. Journal of Psychiatric Research. 2015 Jan;60:187.
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the management of severe and refractory psychotic illness 45. Chandra SR, C.S. Vidhya Annapoorni, Srevidya L.K: complicated by pulmonary embolism. Indian Journal of perceptions: Normal and Abnormal; Reviews in Clinical Psychiatry. 2015;57(4):414. neurology, Indian Academy of Neurology, 2015.Chapter 5, pages 43-53. 34. Chandini Chandaran, Janardhana N. Emotional Intelligence Measurement and its relevance’ Adelaide Journal of Social 46. Chandra SR, Issac TG, Nagaraju BC, Philip M. A Study Work 2015: 2 (15- 20). of Cortical Excitability, Central Motor Conduction, and Cortical Inhibition Using Single Pulse Transcranial Magnetic 35. Chandra P, Babu G, Desai G. Antipsychotics in pregnancy and Stimulation in Patients with Early Frontotemporal and lactation. Indian Journal of Psychiatry. 2015;57(6):303. Alzheimer’s Dementia. Indian J Psychol Med. 2016;38(1):25– 30. 36. Chandra P, Chaturvedi S, Sharma M. Team OSCE: A teaching modality for promotion of multidisciplinary work in mental 47. Chandran, D., Bangalore, N.R., Raj, A., Channaveerachari, health settings. Indian Journal of Psychological Medicine. N.K., Joshi, S.,Paramita, P., Somanathan, R., Kasi, S., Math, 2015;37(3):327. S.B. Psychosocial Impact of the Uttarakhand Flood Disaster on Elderly Survivors. Indian Journal of Gerontology. 2015; 29 (1), 37. Chandra P, Desai G, Reddy D, Thippeswamy H, Saraf G. The 62-76. establishment of a mother-baby inpatient psychiatry unit in India: Adaptation of a Western model to meet local cultural and 48. Chaturvedi SK, Basavarajappa C, Ahamed A. Mental Health resource needs. Indian Journal of Psychiatry. 2015;57(3):290. Care Bill, 2013 and United Nations Convention on the rights of persons with disability: Do they go hand in hand? Indian 38. Chandra S, Issac T, Ayyappan K. New onset psychosis as the Journal of Social Psychiatry. 2015;31(2):107. first manifestation of neuro-psychiatric lupus. A situation causing diagnostic dilemma. Indian Journal of Psychological 49. Chaturvedi SK, Thirthalli J. Recovery Oriented Services: Medicine. 2015;37(3):333. Should We Move from Evidence-Based Practice to Value- Based Practice? Journal of Psychosocial Rehabilitation and 39. Chandra S, Issac T, Gayathri N, Gupta N, Abbas M. A typical Mental Health. 2015 Jun;2(1):1–2. case of myoclonic epilepsy with ragged red fibers (MERRF) and the lessons learned. Journal of Postgraduate Medicine. 50. Chaturvedi SK. Step Sisters of Cinderella. Journal of 2015;61(3):200. Psychosocial Rehabilitation and Mental Health. 2015 Dec;2(2):101–2. 40. Chandra S, Issac T, Philip M, Krishnan A. Elevated antimeasles antibody titre: An association in autoimmune encephalitis. 51. Chickabasaviah Y, Jethwani D, Yadav R. A 58-year-old lady Journal of Neurosciences in Rural Practice. 2015;6(4):536. with progressive neurological syndrome: Presence of an intravascular lymphoma. Neurology India. 2015;63(2):225. 41. Chandra S, Issac T, Shivaram S. Catatonia in children following systemic illness. Indian Journal of Psychological Medicine. 52. Cordeiro T, Sharma M, Thennarasu K, Janardhan Reddy Y. 2015;37(4):413. Symptom dimensions in obsessive-compulsive disorder and obsessive beliefs. Indian Journal of Psychological Medicine. 42. Chandra S, Issac T, Soundarya S, Christopher R. Vitamin 2015;37(4):403. B12 deficiency: An important reversible co-morbidity in neuropsychiatric manifestations. Indian Journal of Psychological 53. Dar MM, Hussain SK, Qadri S, Hussain SS, Fatima SS. Medicine. 2015;37(1):26. Prevalence and Pattern of Psychiatric Morbidity among Children Living in Orphanages of Kashmir. International Journal of 43. Chandra S, Issac T. A case of mitochondrial cytopathy with Health Sciences and Research (IJHSR). 2015;5(11):53–60. exertion induced dystonia. Journal of Pediatric Neurosciences. 2015;10(3):254. 54. Das B, Goyal M, Bhatkar S, Vinny P, Modi M, Lal V, et al. Hereditary inclusion body myopathy: A myopathy with unique 44. Chandra S, Raj P, Issac T. Self-mutilation in neurodegeneration topography of weakness, yet frequently misdiagnosed: Case with brain iron accumulation. Indian Journal of Dermatology. series and review of literature. Annals of Indian Academy of 2015;60(3):290. Neurology. 2016;19(1):119.
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schemes for persons with psychiatric disability. In: Basavarajappa 8. Gayathri N, Chandrasekhar Sagar BK, Srinivas Bharath MM, C, Ashfak Ahammed PC, Desai G, Chaturvedi SK (Eds.). Nuts Mythri R. Manual on Hands–on Workshop in Neurochemistry and Bolts of Starting and Running Psychiatric Rehabilitation and Electron Microscopy. Departments of Neuropathology and Services. NIMHANS Publications, 2016. Neurochemistry, NIMHANS, 2015.
89. Uma H, Megha Rupa & Virupaksha H G. Child Development 9. Gururaj G, Amudhan S. Report of the Symposium on Child (Kannada). In: Janardhana N, Parthasarthy R, Murlidhar D, Mental Health in India: Catalyzing the Public Health Response. Sekar K, Seshadri SP (eds.). Psycho Social Intervention for Centre for Public Health, NIMHANS, Bengaluru, 2016. Children in Difficult Circumstances. NIMHANS Publication, 2015. p. 17-32. 10. Gururaj G, Girish N, Amudhan S. Report of the Workshop on Research Methodology- 2015. Centre for Public Health, 90. Umesh Tonse, Sinu E. Camp approach in the treatment of NIMHANS, Bengaluru, 2015. Substance use disorders. In: Dhanasekara Pandian R, Sinu E, Reni Thomas (eds.). Clinical Social Work Practice in Substance 11. Gururaj G, Pradeep BS, Gopal Beri, Anjali Chauhan, Zoya Use Disorders: A Manual for Professional Social Workers. Rizvi. Report of the youth health survey–Himachal Pradesh. NIMHANS Publication. p. 99-119. Centre for Public Health, NIMHANS, Bengaluru, 2015.
91. Vikram Singh Rawat, Krishna Prasad Muliyala. Psychotropics 12. Gururaj G. Analysis of Highway Road Crashes in India (PI – & Quality of Life: As good as it gets. In: Pathak A, Prasad MK, Supported by World Bank Global Road Safety facility through Thirthalli J, Chaturvedi SK (eds.). Quality of Life in Chronic Road Traffic Injury Research Network), 2016 Mental Illnesses: Exploring New Frontiers. NIMHANS Publication, 2016. p. 144-153. 13. Gururaj G. Traumatic Brain Injury Guidelines for India (contributing author). American Association of Physicians of India, Version 3.1, 2016. Monographs/ Manuals/Reports 14. Janardhan Reddy YC (editor). Refractory cases of OCD (Issue 1. Amudhan S, Girish N, Loganathan S, Arun K. Report of the 2) In: Complicated Cases in Obsessive-Compulsive Disorder. project, Stigma Experience and Related Barriers of Help- Reed Elsevier India Pvt. Ltd. Mumbai, 2015. Seeking in Psychosis, Depressive Disorders and Alcohol Use Disorders: A Hospital Based Exploratory Study. Centre for 15. Jangam KV, Seshadri SP. Report on Workshop on Sensitization Public Health, NIMHANS, Bengaluru, 2016. of Psycho-social Issues of Sportspersons and coaches/officials. NIMHANS in collaboration with NCPCR, New Delhi. 2015 2. Amudhan S, Jagadeesh M. A mental health resource guide for ASHA (Kannada). Centre for Public Health, NIMHANS, 2015. 16. Kishore MT. Social-emotional development of infants. Monograph developed by the Perinatal Psychiatry Services 3. Amudhan S, Jagadeesh M. A mental health resource guide for Unit, NIMHANS. ASHA (English). NIMHANS Publication, 2016. 17. Manjula M, Roopesh BN, Philip M. Report of the funded- 4. Benegal V, Girish N. Harms to Others from Alcohol Use: project, Stress Management in Youth: a Preventive Intervention WHO and Thai Health –A Scoping Assessment. Program. ICSSR, New Delhi, 2015.
5. BV Kathyayani, S Valliammal. Manual on Psychosocial Issues 18. Meena KS, Prakashi Rajaram, Marimuthu P, Vivek Gupta, and Role of a Nurse in Child Adoption, March 2016. Kannappa Shetty. Outcome of a school-based health education program for epilepsy awareness among teachers and school 6. BV Kathyayani. Bridges to the Future: Manual on team building children. NIMHANS, Bangalore 2015. in nursing. College of Nursing, NIMHANS, Bengaluru, September 2016 19. Mehrotra S, Tripathi R, Bharath, Elias J, Michael RJ. Engage to Change: Youth Engagement Program Trainer’s Manual, 7. Chandra SR, CS Vidhya Annapoorni. Hypertension, Diabetes NIMHANS Publication, 2015. and Nervous System, ICP monograph for API (edited by Dr. Shanmugham). 20. Nirmala BP. Family Involvement in Activities of Daily Living
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(ADL). In: Sailaxmi Gandhi (ed.). Activities of Daily Living in 30. Sebastian, J., Hamza, A., Chandra, SR., Manual on Effective Persons with Mental Illness. NIMHANS Publication, 2015. Caregiving for Dementia (Kannada version), NIMHANS Publication 2015. 21. Pandian RD, Sinu E, Thomas R. Clinical Social Work Practice in Substance Use Disorders: A Manual for Professional 31. Sekar K, Kavitha P. Regional consultative workshop on Social Workers. Department of Psychiatric Social Work, psychosocial care for children in difficult circumstances, Report NIMHANS, July 2015. 2015, NIMHANS, Terre des Hommes (NL).
22. Pandian RD, Sinu E, Muralidhar D, Hamza MA, Joseph 32. Shankar SK, Anita Mahadevan. Japanese Encephalitis, Measles AJA. Substance Use Disorders: Workbook for Social Workers. Pathobiology and Currents Concepts of Ischemic Stroke: Department of Psychiatric Social Work, NIMHANS, July Neurology in Trophics, 2nd Edition, Editor: JS Chopra & 2015. Inder MS Sawhney. Elsevier, 2015.
23. Pradeep BS, Gururaj G (Eds). A set 10 different modules for 33. Shari M, Vranda MN. Manual for Primary School Teachers Yuva Parivarthakas under the Project Yuva Spandana. Yuva on Learning Disabilities. Department Psychiatric Social Work, Spandana – the project; Youth, health and lifestyle; Youth NIMHANS 2015. and Safety; Self-development and emotional regulation; Management; Supervision and training; Gender, Sex and 34. Sreedhara KC, Jayanth Kumar K, Gautham MS. Resource Sexuality; Education and Academic issues; Relationship issues manual on stroke care in the community (for ASHA and ANM and intergenerational connect; and supporting skills. workers, in Kannada and English versions. Centre for Public Health, NIMHANS, 2016. 24. Pradeep BS, Gururaj G, Lavanya G, Humera B. Yuva Spandana. Department of Youth Empowerment and Sports, Government 35. Srikala Bharath, Kumar KV. John Viyasagar, Seema Mehrotra. of Karnataka and NIMHANS, 2015. Manosamajik sakshamta ke liye yuwaon me jeevan kaushal ka vikas: Anudeshak ke liye marg darshika. NIMHANS Publication, 25. Radhakrishnan G, Deepak Jayaranjan, Krishna Prasad M, Bangalore 2016 Sivakumar T, Poornima Bhola, Aarti Jagannathan, Hareesh A, Sailaxmi Gandhi. E-Manual on Nurses’ Role in Psychiatric 36. Srikala Bharath, Kumar KV. Manosamajik sakshamta ke liye Rehabilitation Services. Departments of Nursing and yuwaon me jeevan kaushal ka vikas: Jeevan kaushal prashikshiko Psychiatric Rehabilitation Services, NIMHANS, 2016. ke liye marg darshika (Hindi, parts I, II & III). NIMHANS Publication, Bengaluru 2016. 26. Ramachandra, BV Kathyayani, Priya Baby. Synergy model for patient care in Transforming Care at Bedside (TCAB) Ameliorates 37. Sundar Nag Ganjekar. Video learning series on perinatal Patient Care and Improves Vitality of Health Care Team. College psychiatry. Dr. Ramachandra N. Moorthy Foundation and of Nursing, NIMHANS, Bengaluru, January 2016. White Swan Foundation.
27. Ramachandra. Mental Health Issues of Adoptee and Adopted 38. T Sivakumar, U Swarupa. Managing Issues Impairing ADL & Children. Psychosocial Issues and Role of a Nurse in Child IADL among Persons with Mental Illness. In: Sailaxmi Gandhi Adoption, College of Nursing, NIMHANS, Bengaluru, March (ed.). Activities of Daily Living in Persons with Mental Illness. 2016. NIMHANS Publication, 2015.
28. Ravi V, Desai A. Revision and up-dating the (i) Guidelines on 39. Vranda MN. Promotion of Mental health and Psychological establishment of virology laboratory in developing countries. Well-being of Adolescents in Schools using Life Skills WHO, ISBN 978-92-9022-335-1, 2008 and (ii) Establishment Approach (Revised, 2nd Edition). NIMHANS Publication, of PCR laboratory in developing countries, WHO, 2011. 2015.
29. Ravikumar R, Shripad A Patil, Nagarathna S, Veena Kumari 40. Vranda MN. Promotion of Mental Health Skills and HB. (i) Manual on (a) Quality Standards for NABL (b) Psychological Well-being of Adolescents in Schools – A Quality System Procedures for NABL (c) Standard Operating District Model. Project supported by District Administration Procedures (d) Sample Collection (ii) Report on Institutional of Kolar, Government of Karnataka. Department of Psychiatric Antibiotic Policy. Social Work, NIMHANS, 2015.
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Newsletters/Souvenirs 5. Hegde S. Music and emotion regulation. Loudspeaker – A magazine for mental health, published by NIMHANS Centre for Well Being, Summer 2016, 8-10. 1. Hegde S. Sangeetha haagu manasika swasthya (article in Kannada). Yojana (Publications Division, Ministry of 6. James Joseph, Krishna Prasad M. An Unquiet Mind: A Information and Broadcasting) February 2016; 38-40. Memoir of Moods and Madness—Book Review. Loudspeaker – A magazine for mental health, published by NIMHANS 2. KN Jayanthi. Trends in Psychiatric Nursing. Souvenir, ESCON Centre for Well Being, Summer 2016. p.20-21. 2016, 8 January 2016.
7. Jangam K. (i) How can you help children to express their 3. Manjunatha N. Karnataka Mental Health (Manochaitanya) emotions better?. Loudspeaker NCWB Magazine for mental Programme: Indian Psychiatric Society – Karnataka Chapter health (ii) How can you Helping in grief. Loudspeaker – A (IPS KC) in public-private partnership (PPP) model. IPS KC magazine for mental health, published by NIMHANS Newsletter, March 2016:13 Centre for Well Being, Summer 2016 (iii) Information leaflet: Protecting your child from sexual abuse. NCWB. 4. Priya Baby. Level of anxiety in patients undergoing neurosurgery. Souvenir, SINNCON 2015 8. LN Suman. Psychological Trauma: The Invisible Scars, information leaflet, Trauma Recovery Clinic, NIMHANS 5. Radhakrishnan G. Clinical nursing research in maternal and women Centre for Wellbeing, January 2016. related psychiatric problems and interventions- PMS, Postpartum Psychosis/ Depression. Souvenir, ISPN 2016, 15th Annual National 9. Manjula M. Article on Handling Boredom in the Youth / Conference of Indian Society of Psychiatric Nurses, Krishna Adolescents. Loudspeaker – A magazine for mental health, Institute of Medical Sciences, Karad, 13-15 February 2016. published by NIMHANS Centre for Well Being 6. Ramachandra. Substance Use and Addiction Research in 10. Manjula M. How can Parents help their Children handle India. Souvenir, ISPN 2016, 15th Annual National Conference Exam Stress? CMA Mental Arithmetic (India) Pvt. Ltd. of Indian Society of Psychiatric Nurses, Krishna Institute of Thiruvananthapuram, Kerala, 2015. Medical Sciences, Karad, 13-15 February 2016.
11. Manoj Kumar Sharma. (i) SHUT clinic: An internet deaddiction 7. Sailaxmi Gandhi. Clinical Research in Chronic Mental Illness. center right in the heart of Bangalore. The Economic Times, Souvenir, ISPN 2016, 15th Annual National Conference of Mumbai, 18 April 2015 (ii) Ask your question on net addiction, Indian Society of Psychiatric Nurses, Krishna Institute of Bangalore Mirror, 9 June 15 (iii) Now, companies hiring Medical Sciences, Karad, 13-15 February 2016. counsellors like Optum International to wean staff from online shopping. The Economic Times, Mumbai, 29 April 2015 (iv) 8. Sivakumar T. Reducing mental health gap: Reaching out to Addiction to technology growing in the city, The Deccan Herald, unreached. MINDS Newsletter. August 2015. 23 June 2015 (v) Always game for it. Deccan Herald, 10 June 2015 (vi) Shopping till you drop. The Wallet, Virtual Mindness. Articles for General Public/ The Week (special supplement), 21 June 2015 (vii) Modern Iec Materials parenting & relationship with kids in relation to technology use. Indo-Asian News Service, 8 July 2015 (viii) Internet addiction. 1. AB Taly, AK Gupta, Meeka Khanna. Brochure on Sensory Deccan Herald, 21 July 2015 (ix) Now a medical reasoning Integration Activities for ADHD/Autism. not to ban porn websites. Bangalore Mirror, 7 August 2015 (x) Bengaluru doctors develop module to study and cure technology 2. Arun K, Addiction to online games up among teens. The Times addiction. The Economic Times, 12 August 2015 (xi) Internet of India, 22 September 2015. use and its effects. The Mint, 10 August 2015 (xii) Digital detox, The India Today, 11 August 2015 (xiii) Worldwide Webbers’ 3. BP Nirmala. Brochure on Welfare Measures for the Anonymous: If you live, breathe and sleep the internet, try. Neurologically Disabled. Bangalore Mirror, 14 September 2015 (xiv) Support group are compromising on health care. Bangalore Mirror, 26 September 2015 (xv) That caffeine fix could be your ruin, docs warn teens. 4. Girimaji SC, Janardhana N, Sugnyani. Bouddhika angavikalate: Bangalore Mirror, 9 October 2015 (xvi) The pixelated self, The Swaroopa, aaraike, nirvaahane. Yojana, February 2016.
264 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
DNA, Mumbai, 11 October 2015 (xvii) Addiction to technology 23. Prasanthi Nattala, Kalaivani PL, Emily Veena, Indira C. devices. Rajasthan Patrika, 25 October 2015 (xviii) Digital Information leaflet on Drug compliance and preventing relapse hermit. Bangalore Mirror, 6 December 2015 (xix) Nimhans maps in mental illness. dark side of video game. Deccan Herald, 21 December 2015 (xx) Self- esteem and social media. The Times of India, 11 January 24. Prasanthi Nattala, Meena KS, Harish T. Maathina Madhdhu 16 (xxi) Technology detox: Here’s how to identify addiction and (Words that Heal): A short video on Promoting Positive the need for correction. Deccan Chronicle, 13 January 2015 Interactions in Families Living with Mental Illness. (xxii) Technology addiction: Role of SHUT clinic. The Times of India, Chennai, 26 February 2016 (xxiii) Tech addiction: dark 25. Prasanthi Nattala, Meena KS. An information leaflet on side of internet. The Hindu, 6 March 2016 (xxiv) Virtual anxiety Preventing tobacco use among the youth and young adults. manifestation of social anxiety, Deccan Herald, 20 March 2016. 26. Rajeev Joseph Michael, Seema Mehrotra. Article on Emotions 12. Mehta UM. I feel like an outsider - How persons with on the Go. Loudspeaker – A magazine for mental health, schizophrenia can understand other people and communicate published by NIMHANS Centre for Well Being. better. Loudspeaker – A magazine for mental health, published by NIMHANS Centre for Well Being, Summer 2016. 27. Roopesh BN. Overcoming day to day forgetfulness. Loudspeaker – A magazine for mental health, published by 13. Miryala S, Kumar CN. ABC of Antidepressants. Loudspeaker NIMHANS Centre for Well Being. – A magazine for mental health, published by NIMHANS Centre for Well Being. 28. Sailaxmi Gandhi, Lalitha K, Ramachandra, Kanitha D, C Rajeswari. Information leaflet: Adequacy of breast feeding 14. MM Srinivas Bharath. Midulu Bank. Bala Vijnana, published (Kannada & English versions). Department of Nursing, by Karnataka Rajya Vijnana Parishat, Bengaluru, Jan 2016. College of Nursing & Perinatal Psychiatry Services, NIMHANS. 15. Muralidharan K. What is bipolar mood disorder? Loudspeaker – A magazine for mental health, published by NIMHANS 29. Sailaxmi Gandhi, Lalitha K, Ramachandra, Kanitha D, C Centre for Well Being, Summer 2016. Rajeswari. Information leaflet: Hygiene tips for postnatal mother (Kannada & English versions). Department of 16. Nitin Anand. Obsessive Compulsive Disorder. The Hindu, Nursing, College of Nursing & Perinatal Psychiatry Services, Bangalore Edition, 15 March 2016. NIMHANS.
17. Poornima Bhola, Arpitha Ravishankar, Ananya Sinha. Self-injurious 30. Sailaxmi Gandhi, Lalitha K, Ramachandra, S Valliammal. Behaviour: Helping Youth. An Information Brochure for Teachers. Information leaflet: New-born care (Kannada & English Window to Wellbeing Clinic. NIMHANS Centre for Well Being. versions). Department of Nursing, College of Nursing & Perinatal Psychiatry Services, NIMHANS. 18. Poornima Bhola. Dealing with difficult emotions. Loudspeaker – A magazine for mental health, published by NIMHANS 31. Sailaxmi Gandhi, Lalitha K, Ramachandra, S.Valliammal. Centre for Well Being. Information leaflet: Sensory stimulation of baby (Kannada & English versions). Department of Nursing, College of Nursing 19. Prabha S Chandra. Editor, Loudspeaker – A magazine for & Perinatal Psychiatry Services, NIMHANS. mental health, published by NIMHANS Centre for Well Being. 32. Sailaxmi Gandhi, Lalitha K, Valsamma M, AB Taly, Anupam 20. Pradeep BS. Yuva Spandana brochure (English and Kannada) Gupta. Information leaflet: Prevention and Management of Pressure Ulcer (Kannada & English versions). Departments of 21. Prasanthi Nattala, Harish T, Leela Savio, Kalaivani PL, Emily Nursing & Neurological Rehabilitation, NIMHANS. Veena, Lydia Jeevan. Information leaflet on severe mental illness and management guidelines for family members. 33. Sailaxmi Gandhi, Lalitha K., Glory Joseph, Venkatasubramaniam, AB Taly, Prabhu Raj. Information 22. Prasanthi Nattala, Kalaivani PL, Emily Veena, Indira C. leaflet: Management of Caregiver Burden (Kannada & English Information leaflet: Tips for caregivers on how to deal with versions). Departments of Nursing, Psychiatry, Neurology & aggressive behavior in a mentally ill family member. Neurosurgery, NIMHANS, Bengaluru.
National Institute of Mental Health and Neuro Sciences 265 Annual Report 2015-2016
34. Sailaxmi Gandhi, Lalitha K., Sumathi, B. Indira Devi. 42. Sivakumar T, Thirthalli J, Girimaji SC, Sagar JV, Kishore T, Information leaflet: Preventing head injuries due to road crashes Chethan B, Pathak A, James JW, Gandhi S, Kumar D, Bhola and promoting helmet use (Kannada & English versions). P, Jagannathan A, Krishna Prasad M, Hareesh A, Chaturvedi Departments of Nursing & Neurosurgery, NIMHANS. SK. What after me? : Information material for parents of persons with intellectual disability. Psychiatric Rehabilitation 35. Santosh Loganathan. Aging and Elder Care: Making an Services, Department of Psychiatry & Department of Child & elderly family member feel more secure. Loudspeaker – A Adolescent Psychiatry, NIMHANS. magazine for mental health, published by NIMHANS Centre for Well Being. 43. Sudhir PM, Devdutt J. Emotions at workplace. Loudspeaker – A magazine for mental health, published by NIMHANS 36. Satish Girimaji, Janardhana N, Suganani. Intellectual Disability: Centre for Well Being. Nature, care and intervention. Yojana, Development Journal, Kannada Prakashana Division, Information and Broadcasting 44. Uma Hirisave, My Inspiration – My Mother (Kannada). Ministry, Government of India. Memories of a Mother, Ankura Publications, Mysore, 161-163.
37. Seema Mehrotra (i) Mentoring – video clip demonstrating 45. Uma Hirisave, Snigdhasree B. A video on Living a Life of Dignity effective vs ineffective ways of providing support in mentoring with Disability (60 seconds). Ability Fest 2015, India International relationship. Scripted, directed, and shot by Positive Psychology Disability Film Festival, Chennai, September, 2015, Unit (PPU) Team (ii) Peer support - video clips demonstrating effective ways of providing support among peers developed 46. Vranda MN, James P, Shetty K. Poster on Ways to Minimize by the participants of P3 REACH Certificate Course (2015 Social Exclusion. batch) under the supervision of PPU Team (iii) Worrier – a video intended to train individuals about three kinds of thinking 47. Vranda MN, Ramappa T, Shetty K. Poster on Barriers to Social patterns (emotional, rational, and wise mind) developed by the Exclusion of People with Disability. participants of P3 REACH Certificate Course (2015 Batch) under the supervision of PPU Team (iv) Myth busters – video clip prepared for circulation among public intended to educate Books Published the public about the common myths about mental health and illness (v) posters on mental health and wellness and on self- 1. Andrade C. Critical Readings in Psychiatry, No. 8. Ahmedabad: care for depression Zydus Neurosciences, 2015.
38. Shankaranarayana Rao BS. Memory boost hope for kids who 2. Chethan B, Ahamed, PCA, Desai G & Chaturvedi SK cram. The Telegraph, Calcutta, India. October 11, 2015. (Editors). Nuts and Bolts of Starting and Running Psychiatric Rehabilitation Services. NIMHANS Publication, Bengaluru, 39. Sinha Preeti. Emotions and Eating: Feeding your feelings. 2016. Loudspeaker – A magazine for mental health, published by NIMHANS Centre for Well Being, Summer 2016. 3. Pathak A, Prasad MK, Thirthalli J, Chaturvedi SK ((Editors). Quality of Life in Chronic Mental Illnesses: Exploring New 40. Sivakumar T, Kumar D, Thirthalli J, Chethan B, Pathak A, Frontiers. NIMHANS Publication, Bengaluru, 2016. James JW, Ahammed A, Kumar CN, Gandhi S, Desai G, Bhola P, Nirmala BP, Chaturvedi SK. What after me? : Information 4. Sailaxmi Gandhi. Activities of Daily Living for Persons with material for family/caregivers of persons with severe mental Mental Illness: A Book for their caregivers. NIMHANS illness (in Hindi and Kannada). Psychiatric Rehabilitation Publication, Bengaluru, 2015. Services, Department of Psychiatry, NIMHANS. 5. Kavitha P, Sekar K (Eds.). Impact of Psychosocial Problems 41. Sivakumar T, Lath W, Sripathacharya, Rajeev V, Thirthalli J, on Children from Oppressed Community-Implication for Chaturvedi SK. NIMHANS Calendar 2016 with prize winning Social Work Practice and Training. New Delhi: Bloomsbury entries of Art Competition conducted as part of the World Publishing India Pvt. Ltd, 2015. Mental Health Day celebrations. Psychiatric Rehabilitation Services, Department of Psychiatry, NIMHANS, Bengaluru.
266 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 Contributions to Scientific Deliberations
International Deliberations 7. Alafia ,J Roopesh BN, Srinath S. Multiple co-morbid anxiety and mood disorders and sociocultural issues in an adolescent: Challenges and the need for an eclectic approach. 3rd 1. Abhilash PL, Vidyadhara DJ, Yarreiphang H, Raju TR, Phalguni International Conference on Counselling, Psychotherapy and Anand Alladi. Nigral dopaminergic neuronal Calbindin- Wellness and the 4th Congress of the Society for Integrating D28K expression may govern the differential vulnerability Traditional Healing into Counselling Psychology, Psychotherapy to 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in mice and Psychiatry, Christ University, Bengaluru, 5-7 January 2016. strains. CBR International Conference, IISc, Bengaluru, 16-18 November 2015. 8. Alafia ,J Tyagi V, Parameshwaran S, Bhola P, Chethan, Sivakumar T. Challenges and psychosocial interventions in 2. Abhishek Lenka, Ketan Ramakant Jhunjhunwala, Raviteja co-morbid developmental disorder and mental illness: A Kotikalapudi, Pramod Kumar Pal. Evaluation of saccadic eye case report. 3rd International Conference on Counselling, movements in patients with Parkinson’s disease: Effect of Psychotherapy and Wellness and the 4th Congress of the levodopa. 19th International Congress of Parkinson’s Disease and Society for Integrating Traditional Healing into Counselling Movement Disorders, San Diego, CA, USA, 14-18 June 2015. Psychology, Psychotherapy and Psychiatry, Christ University, Bengaluru, 5-7 January 2016. 3. Abhishek Lenka, Nitish L Kamble, Sowmya Venugopal, Ketan Ramakant Jhunjhunwala, Ravi Yadav, Netravathi M, Mahesh 9. Albert Stezin Sunny, Lija George, Ketan Jhunjhunwala, Kandasamy, Nagaraja Moily, Meera Purushottam, Sanjeev Jain, Abhishek Lenka, Jitender Saini, Netravathi M, Pramod Pramod Kumar Pal. What determines the behavioral onset in Kumar Pal. Exploring the grey matter correlates of Wilson’s Huntington’s disease? Insight from 90 genetically confirmed disease using voxel based morphometry. 21st World Congress patients. 19th International Congress of Parkinson’s Disease and on Parkinson’s Disease and Related Disorders, Milan, 6-9 Movement Disorders, San Diego, CA, USA, 14-18 June 2015. December 2015. 4. Abhishek Lenka, Shaik Afsar Pasha, Sandhya Mangalore, 10. Ananya Sinha, Poornima Bhola, Ahalya Raguram, Prabha S Ketan Ramakant Jhunjhunwala, Lija George, Bhawani Chandra. The struggle within-Experience of ethical dilemmas Shankar Bagepally, Jitender Saini, Ravi Yadav, Pramod Kumar among mental health practitioners in psychotherapy and Pal. Corpus callosum volumetry as a tool for differentiating counselling practice. Centenary Conference on Psychology- An subtypes of progressive supranuclear palsy. 21st World Congress International Event, Kolkata, 9-11 October 2015. (Best Paper on Parkinson’s Disease and Related Disorders, Milan, 6-9 Award) December 2015.
11. Ananya Sinha, Poornima Bhola , Ahalya Raguram, Prabha 5. Ajay Kumar Nair, Arun Sasidharan, John P John, Seema S. Chandra. The shadow of the wind: Ethical issues and Mehrotra, Bindu M Kutty. Altered states of consciousness practices in psychotherapy and counselling. The International and neural correlates of well-being in Rajayoga practitioners. Conference on Counselling and Psychotherapy: Diversity in International Conference on Consciousness, Cognition and Training and Practice, Bangalore, 2015. Culture: Implications for the 21st Century, Bengaluru, 9-11 December 2015. 12. Ananya Sinha. Role of psychologists in the correctional home- An experiential account. Centenary Conference on Psychology- 6. Akhil Deepika Kumarasamy, Dhaval P Shukla, Rita Christopher, An International Event, Kolkata, 9-11 October 2015. Sathyaprabha TN, Indira Devi B. Demonstration of subclinical autonomic dysfunction and exploring the potential of heart 13. Andrade C. How placebo works (plenary lecture). World rate variability and IL 10 as biomarkers in traumatic brain Psychiatric Association Regional Congress 2015, Cochin, 25- injury: A pilot study. The International Society for Autonomic 27 September 2015. Neuroscience (ISAN), Stresa, 26-29 September 2015.
National Institute of Mental Health and Neuro Sciences 267 Annual Report 2015-2016
14. Andrade C. Mental health and assisted reproduction: Diagnostic in Psychotherapy. Centenary Conference on Psychology: An and treatment issues (plenary lecture). National Symposium on International Event, Kolkata, India. 9-11 October 2015. Assisted Reproduction, Asian Society of Continuing Medical Education, Goa, 6February 2016. 24. Bindu PS, Nagappa M, Sinha S, Mathuranath PS, Taly AB. Targeted next generation sequencing in children with epileptic 15. Andrade C. Psychopharmacological management of painful encephalopathy: Study from a tertiary care university hospital symptoms in depression (plenary CME lecture). Painful in South India. International Symposium on Benign Infantile Symptoms in Depression, Sri Lanka College of Psychiatrists, Seizures (ISBIS): The 17th Annual Meeting of Infantile Seizure Colombo, 27 February 2016. Society, Tokyo, Japan, 25-26 September 2015. (Silver Award)
16. Anupam Gupta. Prevalence of depression, fatigue and sleep 25. Bindu PS, Govindaraju C, Govindaraju P, Khan NA, disturbance in myelopathy patients: Their correlation with Shwetha C, Nagappa M, Arvinda HR, Gayathri N, Srinivas- functional & neurological recovery. ACRM 2015, Dallas, Texas, Bharath MM, Vandana N, Thangaraj K, Sinha S, Taly AB. USA, 25-30 October 2015. Clinical phenotypes and genotypic spectrum in children with mitochondrial disorders: Study from a tertiary care university 17. Arivazhagan A. Transcranial approaches to pituitary adenoma- hospital in south India. International Congress on Child Indications and outcome. International Society of Pituitary Neurology 2016, Chennai, 22-24 January 2016. Surgeons Conference 2015, Liverpool, United Kingdom, 6-7 November 2015. 26. Birudu Raju, Krishna Reddy. Women Empowerment- current dynamics and challenges in Rural India. International 18. Bandawar M, Field M, Benegal V. Effects of inhibition training Conference on Development Goals at the Grassroots: Policy on event-related potential markers of inhibitory control in Perspectives and Challenges (ICDGG2015), Gandhigram heavy drinkers. International Society of Addiction Medicine, Institute, Dindigal, 22-23 June 2015. Dundee 2015 Congress, Dundee, UK, October 2015. 27. Birudu Raju, Sekar K. Quality of life, perceived social support 19. Benegal V, Girish Rao. Alcohol misuse and harms to others and disability levels among persons with bipolar affective in the transition towns of India. Kettil Brun Society Thematic disorder under remission. International Conference on Conference on Alcohol’s Harm to Others, Helsinki, Finland, Community Mental Health: Trends and Challenges (ICCMH), September 2015. Bengaluru, India, 11-12 December 2015.
20. Bhagya V, Christofer Thomas, Shankaranarayana Rao BS. 28. Cassandra S, Satyanarayana VA. Dating and violence in young Celastrus paniculatus treatment ameliorates chronic stress-induced adults: Role of gender and culture. International Conference cognitive deficits by restoring hippocampal synaptic plasticity. on Counseling Psychotherapy and Wellness, Christ University, International Conference on Neurodegenerative Diseases: Bengaluru, 4-6 January 2016. Pathogenesis to Therapy, Centre for Brain Research, Indian Institute of Science, Bengaluru, India, 16-18 November 2015. 29. Chand P. (i) Developing a collaborative research platform and professional training. Workshops for Community Mental Health in 21. Bharath S, Harish G, Mahadevan A, Pruthi N, Sreenivasamurthy Developing Countries, Taipei, 15-22 November 2015 (ii) Substance SK, Puttamallesh VN, Keshava Prasad TS, Shankar SK. use in India: Changing scenario. Tsaotun Psychiatric Center, Taipei, Tissue-level and cellular characterization of contusion and Taiwan, 16 November 2015 (iii) Substance use among elderly. pericontusion in human traumatic brain injury. Annual meeting International Conference on Mental Policy and Service Model for of the Society for Neuroscience (SFN), Chicago, USA, 17-21 Senile Population, Taichung Veterans General Hospital, Taipei, October 2015. Taiwan, 17 November 2015 (iv) Virtual Knowledge Network (VKN) NIMHANS ECHO: Moving knowledge instead of 22. Bhaskar Rao MJ, Chaturvedi, Arivazhagan A, Mahadevan A, patients, Taipei General Hospital, Taipei, Taiwan, 18 November Satishchandra P. Surgery for focal cortical dysplasia. American 2015 (v) Substance use among schizophrenia: Asian perspective. Society of Epilepsy, Philadelphia, USA, 4-8 December 2015. World Psychiatry Association International Congress (WPAIC), Taipei, Taiwant, 20 November 2015. 23. Bhola P. Voices of trainee therapists: Learning about the journey of professional development. In symposium, Trainees, 30. Chand P, Arun K, Gupta V, Benegal V, Murthy P, Lakshmanan Therapists and Clients: A Confluence of Participant Voices S, Lakshmi R, Kubenthiran N, Varghese M, Arora S.
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Virtual Knowledge Network (VKN) NIMHANS ECHO: of Society for Neuroscience (SfN) Neuroscience, Chicago, Knowledge and skill transfer in addiction & mental health. USA, October 2015. 111th International Congress of Telemedicine Society of India, Kolkatta, 27-29 November 2015. (First Prize for Paper 38. Chetan S Nayak, Sanjib Sinha, Madhu Nagappa, Thennarasu Presentation) K, Arun B Taly. Effect of valproate on the sleep microstructure of patients with juvenile myoclonic epilepsy. International 31. Chandra PS. (i) Keynote lecture - Innovations in Women- League against Epilepsy (ILAE)-31st International Epilepsy Centred Mental Health Care in the Community. An Indian Congress (IEC), Istanbul, Turkey, September 2015. Journey. WPA Regional Congress, Osaka, Japan, June, 2015 (ii) Effective international collaborations. Indo US workshop on HIV 39. Chinna Durai, Birudu Raju, Kavitha Jangam. Current challenges Related Research, ICMR, New Delhi, 10-11 December 2015. in psychiatric community rehabilitation: An observational field study. International Conference on Development goals at the 32. Chandra SR, Thomas Gregor Issac, Sai Deepak, Ravi Teja, gross roots: Policy perspectives and challenges (ICDGG2015), Seby Kulathungara, Arjun Das, Sakkubai Naidu. Pyridoxine Gandhigram Institute, Dindigal, 22-23 June 2015. dependent convulsions among children with refractory seizures- A 3-year follow up study. International Congress on 40. Chithira S, Ravi, SK, Vandana VP. Noun and verb processing in Child Neurology, Chennai, 22-24 January 2016. Malayalam speaking individuals with dementia. 9th Asia Pacific Conference of Speech, Language and Hearing, Guangzhou, 33. Chandra SR, Professor, Thomas Gregor Issac, Nagaraju China,13 October 2015. BC. Utility of TMS as an early biomarker to differentiate between cortical dementia. International Conference on 41. Christopher R. Tandem mass spectrometry: Clinical Neurodegeneration, Centre for Brain Research Conference, applications, IBRO-APRC Associate School of Neuroscience, IISc, Bangalore, 17-19 November 2015. University of Sri Jayewardenepura, Colombo, Sri Lanka, 14-19 December, 2015. 34. Chandran D, Kumar JK. Intervention for socio-cognitive deficits in schizophrenia: Current scenario and preliminary evidences. 42. Datta I. Differential neuronal plasticity of dental pulp stem In Kumar, JK (Chair) Tweaking neural networks to improve cells from exfoliated deciduous and permanent teeth towards cognitive functions: neuropsychological rehabilitation revisited. dopaminergic neurons. 6th International Conference on Stem Symposium on Centenary Conference on Psychology: An Cells and Cancer (ICSCC-2015): Proliferation, Differentiation International Event, Departments of Psychology and Applied and Apoptosis, Pune, India, 2-4 October 2015. Psychology, University of Calcutta, Kolkata, October 2015. 43. Dayana Surendran, Lakshminarayanan Kota, Biju Viswanath, 35. Chaturvedi SK (i) Ethical challenges and dilemmas in Meera Purushottam, Odity Mukherjee, Panicker MM, schizophrenia research. World Psychiatric Association Mathew Varghese, Sanjeev Jain, Preeti G Joshi. Ca2+signaling International Conference, Taipei, 15-18 November 2015 (ii) in human lymphoblastoid cells with different ApoE genotype. Sharing the caring of caregivers in psychiatric rehabilitation 33rd Annual Conference of Indian Academy of Neurosciences, of persons with mental illness. International Workshop Punjab University, Chandigarh, 31 October- 2 November 2015. on Developing the Collaborative Research Platform and Professional Training Workshop for Community Mental 44. Desai A, Ravi V, Padmini S, Vijayalakshmi R, Reeta M, Shah Health in Developing Countries, Taipei, 15-18 November H, Saikia L, Jain A, Dhole T, Daves S, Solomon T, Johnson 2015 (iii) Cancer & Mental Health. International Conference B, Laserson K. Acute encephalitis syndrome of unknown of Yoga, SVYASA, Bangalore, 4 January 2016. etiology: The NIMHANS experience. 17th International Congress on Infectious Diseases, Hyderabad, 2-5 March 2016. 36. Chetan GK. Down regulation of hTERT in glioblastoma cell lines using siRNA. American Society of Human Genetics, 45. Dhananjay I Bhat. Validation of a blast induced neurotrauma Baltimore, USA, October 2015. model using modified Reddy tube in rats: A pilot study. Trauma 2015, Queensland, Australia, 2-4 October 2015. 37. Chetan S Nayak, Mariyappa N, Prasad D, Kaushik K Majumdar, Thennarasu Kandavel, Arun B Taly, Sanjib Sinha. 46. Dovih P, Mani RS, Ashwini MA, Chattopadhyay B, Garg Phase synchronization analysis of K-complex and sleep spindles K, Ramakrishnan U, Madhusudana SN. An assessment on using ensemble measure in healthy subjects. 45th Annual Meet conservation status of bats in India and the impact on public
National Institute of Mental Health and Neuro Sciences 269 Annual Report 2015-2016
health. 3rd International Southeast Asian Bat Conference, Neurological Societies Military Neurosurgeons Meeting, Sarawak, Malaysia, 14-17 August 2015. Jaipur, India, 9-11 October 2015.
47. Dwarakanth S. Chromosomal aberrations in atypical and 56. Gururaj G. Making children safe in traffic: Strategies for safety anaplastic meningiomas: A fluorescence in situ hybridization programmes. 1st National Conference of Safe Kids and 3rd UN study. AANS Annual Meeting, Washington DC, USA, 2-6 Global Road Safety Week, Jaipur, 6-7 May 2015. May 2015. 57. Gururaj G. Measuring road safety behaviours in mixed 48. Dwarakanth S. Differential expression levels of Collagen traffic environments in India and low and middle income 1A2, Tissue inhibitor of metalloproteinase 4 and Ca thepsin countries. International Symposium on Road Safety Behaviour B in intracranial aneurysms and their clinico-radiological Measurements and Indicators, Brussels, 22-24 April 2015. correlation. AANS Annual Meeting, Washington DC, USA 2-6 May 2015. (Best Paper Award). 58. Gururaj G, Rao GN, Pallavi UK, Ashok J, Venkatesh M. Burden of Injuries in rural India: Results of a surveillance programme 49. Ganaie Feroze, R Ravikumar, Ravikumar KL. An approach for the in a southern district of India. International Conference on enhanced identification and typing of streptococcus pneumonia in Epidemiology and Public Health, Valencia, Spain, 4-6 August 2015. culture negative CSF samples of acute meningitis by QMPCR and sequencing. 9th World Congress on Pediatric Infectious 59. Gururaj G., Road safety in India: Challenges and opportunities. Diseases, Rio De Janeiro, Brazil, 15-21 November 2015. 23rd International Traffic Medicine Association Congress, Doha, Qatar, 16-18 November 2015. 50. Gayathri N, Govindraju C, Bindu PS, SonamKothari, AB Taly, Thangaraj K. Mitochondrial disorders with Novel mutations- 60. Gururaj G. Road safety in urban India: Opportunities and A study from tertiary referral centre in South India. 20th challenges. Bloomberg Philanthropies, National Smart City International World Muscle Society Congress, Brighton, UK, Initiative Idea, New Delhi, 6 October 2015. October 2015. 61. Holla B, Viswanath B, Agarwal SM, Kalmady SV, Karthik 51. Gayathri N, Rashmi S, Taly AB, Nalini A. Myofibrillar S, Panda R, Maroky AS, Jayarajan D, Bharath RD, myopathy-An expanding clinical and morphological spectrum Venkatasubramanian G, Benegal V. Effect of baclofen on disorders. 20th International World Muscle Society Congress, alcohol cue-induced craving: A functional magnetic resonance Brighton, UK, October 2015 imaging study. International Society of Addiction Medicine, Dundee 2015 Congress, UK, October 2015. 52. Girish N, Pratima Murthy, Subodh BN, Vivek Benegal, Gururaj G. Harms from alcohol use accrue importantly to the 62. Huddar A, Bindu PS, Nagappa M, Bharath RD, Sanjib Sinha, families. KBS Thematic Meeting: Alcohol’s Harm to Others- Pavagada S Mathuranath, Taly AB. Opsoclonus myoclonus Perceptions, Policies, Approaches, Helsinki, Finland, 14 - 17 ataxia syndrome in children: a retrospective study from a tertiary September 2015. care hospital. International Congress on Child Neurology 2016, Chennai, India, 22-24 January 2016. 53. Girish N, Vivek Benegal, Gururaj G, Pratima Murthy. Translating policies into programmes: Need for greater focus on 63. Issac TG, Chandra SR, Nagaraju BC, Philip M. Transcranial communities in transition. Momentum for Change: Research Magnetic Stimulation (TMS) as early biomarker in and Advocacy Reducing Alcohol Harm Global Alcohol Policy Prognostication and categorization of early Alzheimer and Conference 2015, Edinburgh, Scotland, 7-9 October 2015. Frontotemporal dementias in 25 patients. International Conference on Neurodegenerative Diseases: Pathogenesis to 54. Gururaj G. Finding solutions together. NIMHANS-WHO- Therapy, Bengaluru, November 2015. Gulbenkian Meeting on Integrating Mental Health Care in Non-Communicable Diseases Programmes, Bengaluru, 13 64. Jagadisha T. Severe mental disorders in India: Unique features. November 2015. Developing Collaborative Research Platform and Professional Training Workshop for Community Mental Health in Southeast 55. Gururaj G. Epidemiology of traumatic brain injuries in India. Asia, Taipei Medical University, Taipei, 21 November 2015. 5th Asian Australasian Society of Neurological Surgeons, Neurotrauma Committee and 2nd World Federation of 65. Jagadisha T. Variable Outcome of Schizophrenia, Asian
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Countries World Psychiatric Association International on the Science of Dissemination and Implementation, Marriott Congress of Psychiatry, Taipei, 18-22 November 2015. Marquis, Washington, DC, USA, 14-15 December 2015.
66. Jagannathan A, Jagadisha T, Sivakumar T, Devvarta K, Bhola 74. Ketan Jhunjhunwala, Raviteja Kotikalapudi, Abhishek Lenka, P, Krishna Prasad, Angothu H, Radhakrishnan, Pathak Pramod Kumar Pal. Eye-hand coordination abnormalities A, Chaturvedi SK. Initiatives in vocational rehabilitation in patients with writer’s cramp. 19th International congress of for persons with mental illness: Psychiatric Rehabilitation Parkinson’s disease and Movement Disorders, San Diego, CA, Services, NIMHANS experience. South Asian Conference of USA, 14-18 June 2015. Professional Social Workers, Christ University, Bengaluru, 27- 28 August 2015. 75. Kiran P, Poojar M, Veeramani P, Bharath RD, Nalini A, RavinderJeet Singh, Thomas PT. Distinctive magnetic resonance 67. Jayabal Velmurugan, Gadad V, Mariyappa N, Nagarajan SS, imaging findings of muscle in Duchenne muscular dystrophy. Satishchandra P, Sinha S. Characteristics of inter-ictal and ictal 67th AAN Annual Meeting, Washington, April 2015. gamma (30-70Hz) and ripples (80-200Hz) in absence epilepsy. HFO Workshop, Freiberg, Germany, 10-12 March 2015. 76. Kulkarni Girish Baburao, Sanehalli Manjunath, Subasri Ramakrishnan, Mustare Veerendrakumar. Role of surgery 68. Jayabal Velmurugan, Sinha S, Mariyappa N, Nagarajan SS, in patients with cerebral venous sinus thrombosis with visual Satishchandra P. Effect of seizure frequency on the properties impairment. International Stroke Conference 2016, Los of functional brain networks: Novel observations in patients Angeles, California USA, 16-19 February 2016. with drug naive hot water epilepsy. AES 2015, Philadelphia, 4-8 December 2015. (Best Paper Award) 77. Kulkarni Girish Baburao, Mustare Veerendrakumar. Factor V Leiden mutation with cerebral venous sinus thrombosis and avascular necrosis of bilateral hip joint. International Stroke 69. John AP, Kumarasamy AD, Sujan MU, Devi BI, Raju and Cerebrovascular Diseases Symposium (ISCDS) and TR, Sathyaprabha TN. Autonomic dysfunction in chiari International Congress of Interventional Neurology (ICIN), malformation: A pilot study. The International Society for Hyderabad, 14-15 November 2015. Autonomic Neuroscience (ISAN), Stresa, 26-29 September 2015. 78. Kumar CN, Manjunatha N, Sydney M, Neelaveni S, Math SB. 70. John Vijay Sagar K. Profile of two hundred children with autism Telemedicine in the service of patients in prisons: Experience spectrum disorder from a tertiary care child psychiatry centre in from a tertiary care neuropsychiatric institute. 11th International India. 1st Asia Pacific Regional International Meeting for Autism Congress of Telemedicine Society of India, Kolkata, 27-29 Research (IMFAR), Shanghai, China, 5-7 November 2015. November 2015.
71. Kala P Nair, Vrinda M, Aparna Sahajan, Arun S, Srikumar 79. Kumar CN, Shyamsundar A, Mehta UM, Venkatasubramanian BN, Bindu M Kutty, Shankaranarayana Rao BS. Enriched G, Thirthalli J. Quiz on non-invasive brain stimulation. 1st environment restores epilepsy-induced loss of parvalbumin International symposium on Non-Invasive Brain Stimulation, positive interneurons in the hippocampus. Proceedings of NIMHANS, Bengaluru, India, 20 September 2015. International Conference on Neurodegenerative Diseases: Pathogenesis to Therapy, Centre for Brain Research, Indian 80. Kumar D. (i) Psychology in India. Institute of Health and Institute of Science, Bengaluru, India, 16-18 November 2015. Psychology, University of Liverpool, Liverpool, 12 February 2015 (ii) Evidence-based psychosocial interventions in 72. Kandasamy A, Jose K, Lakshmanan S, Benegal V. Adolescent psychoses amid resource constraints: An Indian experience. substance use disorders: Is it different from adult onset Institute of Health and Psychology, University of Liverpool, substance use disorders?: An Indian experience. International Liverpool, 21 October 2015 (iii) Status of forensic psychology in Society of Addiction Medicine Congress, Dundee, Scotland, India. 16th International Academy of Investigative Psychology 5 October 2015. Conference, London, UK, 15-16 December 2015.
73. Kanuri N, Newman MG, Ruzek JI, Kuhn E, Manjula M, 81. Kumar K J. Tweaking neural networks to improve cognitive Cohen J, Jones M, Taylor CB. Efficacy and effectiveness of functions: Neuropsychological rehabilitation revisited. Centenary CBT-based, online guided self-help programs to reduce anxiety Conference in Psychology, Dept. of Psychology and Dept. of among students in Indian Universities. 8th Annual Conference Applied Psychology, University of Calcutta, 9 -11 October 2015.
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82. Kutty BM, Brain, Cognitive reserve and neural basis of 90. Manjunatha N, Singh G, Varghese M. Will the access of mobile consciousness. International Conference on Consciousness, phone of a psychiatrist is helpful for primary care doctors? Cognition and Culture Implications for the 21st Century, 11th International Congress of Telemedicine Society of India, NIAS, Bangalore, 9- 11 December 2015. Kolkata, 27-29 November 2015.
83. Kutty BM, Kapgal V, Prem N, Hegde P, Rao LT. Combination 91. Marimuthu P. Effect of socio-economical differentials strategies of environmental enrichment, physical exercise and on Tuberculosis prevalence in four metropolitan cities of nutritional supplementation enhance the spatial cognition and India. 35th INCA International Congress, School of Social hippocampal neurogenesis in ventral subicular lesioned rats. 45th Sciences. Jawaharlal Nehru University, New Delhi, 15-17 Annual Meeting of the Society for Neuroscience, McCormic December 2015. Center, Chicago, 17-22 October 2015. 92. Math SB, Kumar CN, Manjunatha N, Sydney M, Rao S, 84. Lalitha K. (i) Review of literature and developing conceptual Neelaveni S. Reaching the unreached: Cost-effective model framework. International conference on Authentication of of tele-psychiatry in a limited resource setting in India. 11th Scientific Research for Eminence, Translating Research into International congress of Telemedicine Society of India. Practice, Balaji Medical college and Hospital, Chennai, 26 Kolkata, 27-29 November 2015. June 2015 (ii) Nursing education in India, present status. International Conference on Nursing Education and Practice 93. Meera SS, Girimaji SC, Seshadri SP, Philip M, Shivashankar Local to Global, Sinhgad College of Nursing, Pune, 28-29 N. Observations of Social Communication (OSC) - A direct January 2016 (iii) Keynote address. International Conference observation tool to measure social communication in the on Nursing Education and Practice Local to Global, Sinhgad broad autism phenotype. 9thAsia Pacific Speech Language and College of Nursing, Pune, 28-29 January 2016. Hearing Conference, Guangzhou, 9-11 October 2015.
85. Madhavadas S, Kapgal VK, Kutty BM, Subramanian S. The 94. Meera SS, Girimaji SC, Seshadri SP, Philip M, Shivashankar N. benefits of dark chocolate consumption on monosodium Study of communication deficits in the siblings of children with glutamate-induced non-transgenic Alzheimer disease model autism spectrum disorders using the children’s communication rats: Biochemical, behavioural and histological studies. Centre checklist-2: A pilot initiative from India. International Meeting for Brain Research Conference 2015, Bengaluru, India, 16-18 For Autism Research (IMFAR), Salt Lake City, Utah, USA, November 2015. May 2015.
86. Mahati K, Bhagya V, Raju TR, Shankaranarayana Rao BS. 95. Meera SS, Dadlani N, Swaminathan D, Yamini BK, Enriched environment potentiates actions of antidepressants Shivashankar N. Relapse of stuttering with onset of Primary and ameliorates depression-induced deficits in cognition and Progressive Aphasia (PPA): A case report. 9th Asia Pacific synaptic plasticity. Proceedings of International Symposium Speech Language and Hearing Conference, Guangzhou, 9-11 on Neuropeptides and Neurotransmitters: Role in Physiology Oct 2015. and Pathophysiology and Second Meeting of Indian Sub- Continental Branch of the International Neuropeptide Society, 96. Meera SS, Ravi GS, Mohammad AJS, Sabu B, Shivashankar NISER, Bhubaneswar, Odisha, 13-14 December 2015. N. Autism spectrum disorders- understanding parental pursuit to access speech-language services in the Indian context. 87. Mani RS. Rabies. 9th International Short Course in Clinical International Meeting For Autism Research (IMFAR), Salt Tropical Medicine 2015, Infectious Diseases Training and Lake City, Utah, USA, May 2015. Research Center, CMC Vellore, 19 November 2015. 97. Megha Rupa, Hirisave U, Ramkrishna J. NIMHANS parent 88. Manjula R, Shruti M, Padmanabhan B. Discovery of novel human training videos. Deakin Child Study Centre, School of SIRT1 inhibitors by in silico screening. 13th Conference of the Psychology, Deakin University, Australia, 7 May 2015. Asian Crystallographic Association, Kolkata, 5-8 December 2015. 98. Mehta UM, Eack SM, Thermenos HW, Mesholam-Gateley R, 89. Manjunatha N, Bharath S, Varghese M. Opportunities and Mathew IT, Keshavan MS. Morphometry of the mirror neuron challenges in community based psychiatric rehabilitation: system and social cognition performance in schizophrenia. Sakalawara Model. World Psychiatric Association-Regional International Congress on Schizophrenia Research, Colorado Congress-2015, Kochi, 25-27 September 2015. Springs, USA, 28 March-1 April 2015.
272 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
99. Mehta UM. Social cognition deficits in psychiatric disorders- A 107. Nandeesh BN, Anita Mahadevan, Amey Rajan Savardekar, translational neuroscience perspective. International Conference Yasha TC, Jitendra Saini, Vani Santosh. A clinicopathological on Emotion and Cognition, Allahabad, 14-16 December 2015. study of skull base tumors from a tertiary care hospital. 64th Annual Conference of Indian Association of Pathologists 100. Mrunal Bandawar. (i) Inhibitory control training in high-risk and Microbiologists and Annual Conference of International population for alcoholism with a smartphone game. UKCTAS Academy of Pathology- Indian Division. APCON 2015, Early Carrier Conference, Bristol, 15-16 September 2015 Cochin December 2015. (ii) Effects of inhibition training on event-related potential markers of inhibitory control in heavy drinkers- A pilot study 108. Narayanaswamy JC, Jose D, Agarwal SM, Kalmady SV, (a) International Society for Addiction Medicine conference, Baruah U, Shivakumar V, Prasad C, Viswanath B, Rao NP, Dundee, Scotland, 4-9 October 2015 (b) UKCRC, Edinburgh, Venkatasubramanian G, Reddy YC. Neuro-hemodynamic Scotland 19-20 November 2015 (c) United Kingdom Society endophenotypes of emotional interference in OCD: fMRI of Behavioral Medicine Annual Meeting, New Castle, UK, 7-8 study using emotion counting stroop task. International College December 2015 (d) Alcohol Research Early Career Symposium, of Obsessive Compulsive Spectrum Disorders (ICOCS), Birmingham, UK, 29-30 March 2016. Amsterdam, Netherlands, September 2015.
101. Muntaj S, Kruthika Vinod TP, Vedamurthy AB. Genetic 109. Nayak C, Sinha S, Nagappa M, Thennarasu K, Taly AB. Effect profiling of Indian patients with glutaric acidemia type I. 22nd of valproate on the sleep microstructure of in patients with World Congress of Neurology (WCN 2015), Santiago Chile, Juvenile Myoclonic Epilepsy ( JME). 31st International Epilepsy 31 October- 5 November 2015. Congress (IEC 2015), Istanbul, Turkey, 4-9 September 2015. (Awarded Travel Bursary) 102. Nagappa M. Mitochondrial disorders: A neurologist’s perspective. 2nd Annual Mito Symposium, NIMHANS, 110. Nayak CS, Mariyappa N, Prasad PD, Majumdar KK, Bengaluru, 22 August 2015. Kandavel T, Taly AB, Sinha S. Phase synchronization analysis of K-complex and Sleep spindles using ensemble measure 103. Nagappa M, Bindu PS, Govindaraju C, Sonam K, in healthy subjects, 45th Annual Meeting of Society for Chiplunkar S, Gayathri N, Srinivas-Bharath MM, Arvinda Neuroscience (SFN), Chicago, USA, 17-21 October 2015. HR,Govindaraju P, Khan N, Nunia V, Thangaraj K, Sinha S, Taly AB. Basal ganglionic-stroke syndrome secondary to 111. Nidhi Menon, Binukumar B. (i) Intracluster correlations mineralizing microangiopathy in children: Emerging evidence coefficients for factors influencing HIV among Indian of mitochondrial dysfunction. International Congress on Child women.12th SEA Regional Scientific Meeting of the Neurology 2016, Chennai, 22-24 January 2016. International Epidemiological Association (IEA-SEACON 2015), Bangkok, Thailand, November, 24-26, 2015 (ii) A 104. Nagappa M, Bindu PS, Mahadevan A, Sinha S, Mathuranath Multilevel modelling approach to identify the risk estimates PS, Taly AB. Intravenous pulsed methyl prednisolone in of HIV among Indian women. International Conference on pediatric Anti-N-Methyl-D-Aspartate-Receptor (NMDAR) Statistics for Twenty First Century 2015 (ICSTC-2015), encephalitis. International Congress on Child Neurology 2016, Trivandrum, Kerala, 17-19 December 2015. 22-24 January 2016. 112. Nishanth Sadashiva, Paritosh Pandey. Moyamoya disease: 105. Nagarathna S, Shayanki LM, Netravathi M, Veenakumari HB, Experience with direct and indirect revascularization in 133 Kouser F, Sayani M, Marimuthu P, Satishchandra. Thirty five hemispheres from a non-endemic region. WFNS Interim years scenario of Cryptococcal meningitis: An analysis in pre and Meet-2015, Rome, Italy, September 2015. post HIV era Departments of Neuromicrobiology, Neurology, Biostatistics, NIMHANS, Bengaluru. International Conference 113. Nithyanada S, Birudu Raju, Muralidhar D. Subjective wellbeing on Infectious Diseases, Hyderabad, 2-5 March 2016. of Transgenders in Bengaluru. International Conference on Community Mental Health: Trends and Challenges (ICCMH), 106. Nandakumar DN, Palaniswamy R, Hurmath FK. Role of Bengaluru, 11-12 December 2015. subtypes of glutamate receptors in intracellular antioxidant metabolism and its receptor expression in glioblastoma. IBRO 114. Nupur Pruthi. (i) Decision making in High Cervical Trauma: 2015, 9th World Congress in Neuroscience, Rio de Janeiro, C2 body fractures. 24th Annual National Conference of Brazil, 7-11 July 2015. Neurotrauma Society of India, Bengaluru, 21-23 August 2015
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(ii) Establishing a training model for side to side anastomoses (i) Glial perspective on the neurodegeneration: Inflammation using rat femoral vessels. 15th Annual conference of mediated neurotoxicity. FENS-SfN Summer School 2015 Cerebrovascular Society of India, Ludhiana, 18-20 September Shared Mechanisms and Specificity in Neurodegenerative 2015 (iii) Can the position of the vertebral artery be predicted Diseases, Bologna, Italy, 7-13 June 2015 (ii) Neuron-glial on a lateral view X-ray of the craniovertebral junction? A interaction in pathogenesis of sporadic Amyotrophic Lateral radiological anatomy study of C2 vertebra. 2nd National Sclerosis (ALS). 45th Annual Meeting of Neuroscience 2015, Conference of Minimally Invasive Spine Surgeons of India, Society for Neuroscience (SfN), Chicago, October 2015. Mumbai. 24-25 October 2015. 122. Poornima Mahindru, Manoj Kumar Sharma, Santosh K 115. Oliveira J, Debnath M, Etain B, Bennabi M, Hamdani N, Chaturvedi. Clinical validation of 7-item psychiatric morbidity Lajnef M, Bengoufa D, Fortier C, Marzais F, Boukouaci W, scale. 13th European Conference on Psychological Assessment, Bellivier F, Kahn JP, Henry C, Charron D, Krishnamoorthy Zurich, Switzerland, 22-25 July 2015. R, Leboyer M, Tamouza R. Nitric oxide synthase 3 gene variants are associated with violent suicidal behaviour in bipolar 123. Prabhakar P, Chandra SR, Christopher R. MiR-486- disorder patients. European Federation for Immunogenetics 5p-mediated regulation of homocysteine through Conference, Geneva, Switzerland, 26-29 April 2015. 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) in vascular dementia due to cerebral small 116. Padmanabhan B. Structure based drug discovery of small vessel disease. International Conference on Neurodegenerative molecules for the BRD2 bromodomain associated with cancer Disease: Pathogenesis to Therapy, Indian Institute of Science, and neurodegenerative diseases. 14th FAOBMB Congress & Bengaluru, 16-18 November 2015. 84th Annual Meeting of SBC, Hyderabad, 27-30 November 2015. 124. Pramod Kumar Pal (i) The clinician loses his balance: How to approach genetic and non-genetic ataxia. 19th International 117. Padmavathy D, Taranum Taj. What women in the perinatal Congress of Parkinson’s Disease and Movement Disorders, San period feel about rituals and customs related to child birth. Diego, CA, USA, 14-18 June 2015 (ii) Electrophysiological National Conference on Motherhood and Mental Health evaluation of Psychogenic Movement Disorders. Plenary (MMH), 31 October 2015. Session on Psychogenic Movement Disorders. 21st World Congress on Parkinson’s Disease and Related Disorders, Milan, 118. Pandareesh MD, Srinivas Bharath MM, Anand T. Italy, 6-9 December, 2015. Neuroprotective propensity of bacopa monniera: An in vitro (PC12 cells) and in vivo (Wistar rats) study. 25th Biennial 125. Prathibha Surathi, Abu Zafar, Ravi Yadav , Dwarkanath Meeting of the International Society for Neurochemistry (ISN), Srinivas, Pramod Kumar Pal. DBS in dystonic camptocormia: 13th Meeting of the Asia-Pacific Society for Neurochemistry A case report and review. 19th International Congress of (APSN) and 35th Meeting of the Australian Society for Parkinson’s Disease and Movement Disorders, San Diego, CA, Neurochemistry (ASN), Cairns, Queensland, Australia, 23-27 USA, 14-18 June 2015. August 2015. 126. Pratibha Surathi, Abhishek Lenka, Ketan Jhunjhunwala, 119. Pendharkar H. Non accidental injury: Retrospective imaging Satyaprabha TN, Ravi Yadav, Netravathi M, Dwarakanath analysis demonstrates the entity to be under recognized. 12th Srinivas, Pramod Kumar Pal. Effect of STN-Deep Brain Symposium: Neurotrauma Society, Cape Town, South Africa, Stimulation on autonomic function in patients with PD. 19th 1-4 February 2016. International Congress of Parkinson’s Disease and Movement Disorders, San Diego, CA, USA, 14-18 June 2015. 120. Phalguni Anand Alladi, Vidyadhara DJ, Yarreiphang H, Raju TR. Admixing of two mice strains with differential susceptibility 127. Preethish-Kumar Veeramani, Nalini Atchayaram, Jitender to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Saini, Kiran Polavarapu, Ravinder Jeet Singh. Distal bimelic positively modulates the nigral dopaminergic phenotype. 19th amyotrophy: A phenotypic variant of brachial monomelic International Congress of Parkinson’s Disease and Movement amyotrophy/ hirayama disease having identical features on Disorders, San Diego, California, USA, 14-18 June 2015. MR Imaging. 67th Annual Meet of American Academy of Neurology, Washington DC, April 2015. 121. Pooja Shree Mishra, Dinesh K Dhull, Vijayalakshmi K, Sathyaprabha TN, Nalini A, Phalguni Anand Alladi, Raju TR. 128. Preethish-Kumar Veeramani, Nalini Atchayaram, Kiran
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Polavarapu, Nagarju BC, Ravinder Jeet Singh, Chandrajit putative biomarker augments neuroinflammation in sporadic Prasad. Sequential transcranial magnetic stimulation amyotrophic lateral sclerosis. 45th Annual Meeting Neuroscience demonstrates dynamic changes on neck flexion in monomelic 2015, Society for Neuroscience (SfN), Chicago, October 2015. amyotrophy/hirayama disease. 67th Annual Meet of American Academy of Neurology, Washington DC, April 2015. 135. Ramachandra. Journey of a researcher. International Center for Collaborative Research, Omayal Achi College of Nursing, 129. Raghavendra K, Bharath RD, Sinha S, Chaitanya G, Panda Chennai, 29 January 2016. R, Satishchandra P. White matter abnormalities in hot water epilepsy revealed by diffusion tensor imaging analysis: A voxel 136. Rao NP, Jacob A, Varambally S, Bharath S, Venkatasubramanian wise approach. IEC 2015, Istanbul, Turkey, 4-9 September 2015. G, Gangadhar BN. Oxytocin Modulation of Neural Circuitry for Trust in Schizophrenia: A fMRI Study. 54th Annual 130. Rajesh K, Keshav KJ, Benegal V, Roopesh BN. Neurocognitive Conference of American College of Neuropsychopharmacology, deficits and effectiveness of a newly designed intervention Hollywood, Florida, USA, 6 - 10 December 2015. in Alcoholism. Symposium on Tweaking Neural Networks to Improve Cognitive Functions: Neuropsychological 137. Rao NP. Metacognitive dysfunction in schizophrenia: Neural Rehabilitation Revisited in Centenary Conference on correlates of self vs other are thinking. International Conference Psychology, West Bengal, Kolkata, 9 -11 October 2015. on Consciousness, Cognition and Culture: Implications for the 21st Century, Bengaluru, 9-11 December 2015. 131. Rajeshwari Parida, Kalyani Thakur, Sai Shyam, Manjunatha M Venkataswamy, TN Sathyaprabha, Raju TR and Vijay K 138. Ratna Jyothi, Ajay Nair, Arun Sasidharan, John P John, Seema Kalia. Expression of TNF-α and IL-2 and their receptors and Mehrotra, Ravindra Panth, Kutty BM. Enhancement in its relation to cellular damage in a human malignant glioma cell cortical alpha1 (8-10 Hz) tuning as a regulatory phenomenon line after Temozolomide and 2-DG treatment. Global Cancer for efficient cognitive processing in practitioners of vipassana Summit 2015, J.N. Tata Auditorium, IISc, Bengaluru, 18-20 meditation. International Conference on Consciousness, November 2015. Cognition and Culture: Implications for the 21st Century, NIAS, Bengaluru, 9-11 December 2015. 132. Rajeswaran J. (i) EEG Neuro feedback in TBI. International Conference on Applied Psychology, Colombo, Sri Lanka, 28- 139. Ravi GS, Thennarasu K. Performance of maternal and child 30 August 2015 (ii) EEG Neuro Feedback Training in Clinical health indicators in selected districts of Karnataka state, India: Conditions. RAK Medical & Health Sciences University, Ras A trend analysis. 12th SEA Regional Scientific Meeting of Al Khaimah, UAE, April 2015 (iii) Stress and adolescence- the International Epidemiological Association 2015 (IEA- Brain behavior perspective. Annual Counselors Exposition SEACON 2015), Bangkok, Thailand, 24- 26 November 2015. (ACE) on Stress and Adolescence- Brain Behavior Perspective, Mohammed bin Rashid Medical Academic Centre, Dubai 140. Ravi V, Padmini Srikantiah, Vijayalakshmi Reddy, Anita Desai Health City, Dubai, 27-28 April 2015 (iv) Stress and , Reeta S Mani, Shah Hossain, Lahari Saikia, Amita Jain, Adolescence- Brain Behavior Perspective. RAK Medical & Tapan Dhole, Sharon Daves and Kayla Laserson. Etiology of Health Sciences University, Ras Al Khaimah, UAE, 29 April Acute Encephalitis Syndrome in India, Algorithmic approach 2015 (v) Creativity and cognition- A neuroscience perspective. to diagnosis of AES in India. ID Week 2015- An International International Conference on Consciousness, Cognition and Conference on Infectious Diseases, San Diego, USA, 6-10 Culture: Implications for the 21st century, National Institute of October 2015. Advanced Studies, Bengaluru, 9-11 December 2015. 141. Ravi V. (i) (a) Role of NIMHANS as a reference laboratory of 133. Rajini M Naduthota, Rita Christopher, Ravi Yadav, Pramod the SEAR JE Laboratory Network (b) The recent technologies Kumar Pal. A comparative study of oxidative stress markers on diagnostics of AES etiology (c) Recent Experience on between the tremor dominant and akinetic-rigid subtypes AES surveillance in India (d) Safety & Quality assurance of patients with Parkinson’s disease. 21st World Congress on implementation in JE testing. Bi-Regional Workshop on Parkinson’s Disease and Related Disorders, Milan, Italy, 6-9 Strengthening the Capacity of Japanese Encephalitis ( JE) December 2015. Laboratory Network in the WHO South-East Asia and Western Pacific Region, Bangkok, Thailand, 17-21 August 134. Raju TR, Varghese AM, Ghosh M, Mishra PS, Vijayalakshmi 2015 (ii) Strengthening laboratory diagnostics and surveillance K, Alladi PA, Sathyaprabha TN, Nalini A. Chitotriosidase, a of acute encephalitis syndrome in India. 1st Global Health
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Security Agenda Conference, CDC, Atlanta, USA, 10-12 145. Rose Dawn Bharath. (i) Resting state Functional Brain Imaging- February 2016. Introduction (ii) Functional Brain Imaging- Applications (iii) Functional Brain Imaging- Basics. Ara Damansara Medical 142. Ravi V, Anita Desai, Manjunath RJ, Mahesh Kumar, Priti Centre, Malaysia, 19-21 February 2016. Kumar, Ruth Montgomery. Immune signatures of responses to infection with Dengue virus. DBT Indo-USA Symposium on 146. Sabitha K Rajesh, Niharika Sane, Laxmi T Rao. Genestein Contemporary Topics in Immunology: Systems Immunology, ameliorates neurological deficits and enhances structural Infant Immunity and Adjuvant Science, New Delhi, 28-29 recovery in endothelin-1 induced stroke rats. Society for January 2016. NeuroScience, Chicago, USA, 19-23 October 2015.
143. Ravikumar R. (i) AMR in the South Asian region. Symposium 147. Sadananda Reddy. Coping strategies and level of expressed III- Antimicrobial Resistance, Annual Scientific Sessions of emotions among persons with alcohol dependence. South Asian the Sri Lanka College of Microbiologists, Sri Lanka, 11-16 Conference on Dignity and Worth of Peoples in a Globalised August 2015 (ii) A prospective clinico-microbiological study Economy: Role of State, Social Enterprises, Corporate and of tuberculous meningitis in a Neuro care center: An Indian Social Workers, Christ University, Bengaluru, 27-28 August perspective. Emerging infectious diseases, Hyatt Regency, 2015. Atlanta, USA, 24-26 August 2015 (iii) Current applications of mass spectrometry in clinical microbiology. 5th International 148. Sampath S. (i) Extended endonasal endoscopic transclival Conference on Proteomics and Bioinformatics, Valencia, clipping of basilar artery aneurysms. Congress of Neurological Spain, 2 September 2015 (iv) Study of phosphoproteome of Surgeons Annual meeting, New Orleans, Louisiana, the pathogenic yeast Cryptococcus neoformansvargrubii. 5th USA, 26-30 September 2015 (ii) Extended endoscopic International Conference on Proteomics and Bioinformatics, endonasaltranscival approach to clip Basilar artery aneurysm. Valencia, Spain, 3 September 2015 (v) An Approach for the 12th International Conference of Cerebrovascular Surgery 2016 enhanced identification and typing of Streptococcus pneumonia and 1st Asian Australiasian Society of Neurological Surgeons in culture negative CSF samples of acute meningitis by QMPCR Conference, Mumbai, 26-28 February 2016. and Sequencing (with Ganaie Feroze, K L Ravikumar). Rio De Janeiro, Brazil.15-21 November 2015 (vi) Matrix assisted 149. Sandatta Sen, Meera Purushotaman, Lokeshnarayanan, laser desorption Ionization time of flight mass spectrometry Nalini.A, Chandra SR, Srikalabharath, Suresh Kumar, Sonam et (MALDI TOF MS) analysis of streptococcus pneumoniae from al. Expansion of nucleotide repeat length in neurodegenerative cerebrospinal fluid for the diagnosis of acute bacterial meningitis. disease IISC Conference Bangalore, International Conference 6th International conference and Expo on Proteomics, Atlanta, on Neurodegeneration, IISc, Bengaluru, 17-19 November 2015 USA, 29 March 2016 (vii) Does proteogenomics study give answer to diagnosis of infectious and non-infectious diseases 150. Sanjeev Jain. Madness in India: Society, State and mental health of nervous system? 6th International Conference and Expo on care; Anthropology and global health: Interrogating theory, policy Proteomics, Atlanta, USA, 30 March 2016. and practice. University of Sussex, UK, 9-11 September 2015.
151. Santosh Loganathan, Thennarasu K, Varghese M. Effectiveness of street theatre to create awareness about schizophrenia: a randomized controlled trial. WPA Regional Congress at Kochi, Kerala, India, 25-27 September 2015.
152. Sasidharan A, Nair AK, Lukose A, John JP, Kutty BM. Patients with recent-onset Schizophrenia show aberrant brain dynamics during gestalt perception and corollary discharge mechanism
Symposium on Antimicrobial Resistance, Annual Scientific Sessions of the Sri as a marker of dysfunctional predictive error. International Lanka College of Microbiologists, Sri Lanka Conference on Neurodegenerative Diseases: Pathogenesis to Therapy, Center for Brain Research, IISc, Bengaluru, 144. Reddy PR. Empathy: Cognitive neuroscience perspective. Karnataka, November 2015. International Conference on Consciousness, Cognition and Culture: Implications for the 21st Century. National Institute of 153. Sathishchandra P. Genetics of epilepsy: Indian perspective. Advanced Studies, Bengaluru, India, 9-11 December 2015. International Workshop on Epilepsy, GP Pant Institute for
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Post Graduate Medical Education and Research, New Delhi, 6 163. Shripad A Patil. (i) Fundamental immunology and its March 2016. therapeutic potential: Demyelination in diabetes. Cold Spring Harbor meeting, New York, USA, 14-18 April 2015 154. Sathyaprabha TN. Dysregulation of cardiac autonomic function (ii) Myasthenia gravis: An auto immune disorder. Federation in offspring exposed to alcohol during antenatal period. 4th of Immunological Society of Asia Oceania (FIMSA), PGI, International Conference on Addiction Research & Therapy, Chandigarh, 17-19 March 2015. Orlando, Florida, 3-5 August 2015. 164. Shruthi R, Christopher R, Devi BI, Bhat DI. Evaluation of the 155. Shaik M, Vedumurthy AB, Kruthika-Vinod TP. Correlation role of endothelial nitric oxide synthase (eNOS) gene variants of genotype with biochemical profile in patients with glutaric in Indian population with natural history of aneurysmal acidemia type I: A study from India. 11th Asia Pacific Conference subarachnoid haemorrhage (aSAH). International conference on Human Genetics 2015 (APCHG 2015), Hanoi, Vietnam, on Neurodegenerative Diseases: Pathogenesis to Therapy, IISc, 16-19 September 2015. Bengaluru, 16-18 November 2015.
156. Shekhar P Seshadri, (i) Panelist & Chairperson, Global 165. Shukla D. (i) Surgical Management of DACA Aneurysms. symposium on Children’s Mental Health, Hague, Netherlands, WFNS Interim Meet-2015, Rome, Italy, 2015 (ii) Aggressive 26-28 May 2015 (ii) Speaker/Panelist, Global Symposium on management of cerebrovascular vasospasm with direct intra- Mental Health & Social Justice, New Delhi, 12-13 April 2015. arterial nimodipine therapy. International Conference of Cerebrovascular Surgery (ICCVS), Mumbai, 2016. 157. Shere S, Bharath S, Subramanian S, Purushottam M. Role of copper in Alzheimer’s dementia: A controlled study. Alzheimer’s 166. Shukla L, Shukla T, Bokka S, Kandasamy A, Murthy P, Chand Association International Conference 2015, Washington DC, P, Benegal V. Correlates of Baclofen’s effectiveness in alcohol USA 18-23 July 2015. dependence. International Society of Addiction Medicine, Dundee 2015 Congress, Dundee, UK, October 2015. 158. Shiksha Sharan, Bhupesh Mehta, Joshi NB, Joshi PG. Glutamate handling properties of astrocytes in rat spinal cord. 167. Shyam Sundar A. Arumugham SS. Clinical heterogeneity 33rd Annual conference of Indian Academy of Neurosciences, in obsessive-compulsive disorder. WPA Regional Congress, Punjab University, Chandigarh, 31 October- 2 November 2015. Kochi, India. 26 September 2015.
159. Shilpa BM, Bhagya V, Srikumar BN, Shankaranarayana Rao 168. Singh S, Gururaj G. Risk behaviours impacting health of BS. Chronic escitalopram treatment ameliorates stress-induced youth: A cross-sectional survey in Bengaluru. First Mysore depressive-like behaviour and cognitive deficits by restoring International Conference on Medical and Social Sciences 2015, the expression of neurotrophic factors in the hippocampus 24-27 November 2015. and frontal cortex but not in the amygdala. Proceedings of International Conference on Neurodegenerative Diseases: 169. Singhal M, Manjula M, Vijayasagar J. Efficacy of an Indian Pathogenesis to Therapy. Centre for Brain Research, Indian indicated program for adolescents at-risk for depression. 1st Institute of Science, Bengaluru, India. 16-18 November 2015. International Congress of Clinical and Health Psychology with Children and Adolescents, University of Miguel Hernández, 160. Shivakumar P, Loganathan S, Phillip M, Varghese M. Carers’ Madrid, Spain, 19-22 November 2015. (Best International needs assessment in dementia- Indian perspective. Alzhimer’s Research Award) Association International Conference, Washington DC, USA, July 2015. 170. Sinha S. (i) Is it focal or generalized epilepsy? How EEG can help. (ii) Periodic discharges in EEG. International Epilepsy 161. Shivakumar P, Sadanand S, Loganathan S, Phillip M, Bharath conference, New Delhi, 4-5 March 2016. S, Varghese M. Pathways to Dementia Care in India. 30th International Conference of Alzheimer’s Disease, Perth, 171. Siram R, Bindu PS, Nagappa M, Yasha TC, Mahadevan Australia, April 2015. A, Srinivas-Bharath MM, Gayathri N, Arvinda HR, Taly AB. Clinical profile of hereditary neuropathies in children: 162. Shoba Srinath. DSM-5 and child psychiatry: An overview of experience from a tertiary care university hospital in south changes. 6th Indian Global Psychiatric Initiative, New Delhi, 6 India. International Congress on Child Neurology 2016, January 2015. Chennai, India, 22-24 January 2016.
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172. Sinha S, Nayak CS, Nagappa M, Taly AB, Thennarasu K. WHO School Health Technical Meeting on Global School Lack of heart rate variability (HRV) during apnea in drug naïve Health Initiatives: Achieving Health and Education Outcomes, patients with temporal lobe epilepsy: A marker of SUDEP? 31st Bangkok, Thailand, 23-25 November 2015 (ii) Prevention of International Epilepsy Congress -IEC 2015, Istanbul, Turkey, relapses in schizophrenia. Symposium on Fight against Stigma, 4-9 September 2015. World Association of Social Psychiatry and Sanofi, Yerevan, Armenia, 14 May 2015. 173. Sivakumar PT, Srikanth M, Shivakumar V, Venkatasubramanian G, Nagalakshmi RM, Harshita V, Bharath S, Saini J, John JP, 180. Srimal Achalia G, Shah A. A study on emotion-focused Kumar KJ, Kandavel T, Varghese M. Cognitive correlates of techniques in integrated psychotherapy. Centenary Subregional Hippocampal volumetry in late onset depression: Conference on Psychology (Sub-theme: Psychopathology and A 3 Tesla MRI Study. American Association for Geriatric Psychotherapeutics). University of Calcutta, Kolkata, West Psychiatry Annual Meeting, Washington, DC, USA, March Bengal, 9-11 October 2015. 17-20, 2016. 181. Srinivas Bharath MM. Exploring the role of redox and 174. Sivakumar PT. Promoting indian research on ageing and mitochondrial dynamics in neuromuscular disorders. University Alzheimer’s disease risk in Down syndrome: Lessons from of South Florida, Tampa, USA, 22 October 2015. dementia research in India. 12th World Down Syndrome Congress, Chennai, August 18-21, 2015. 182. Subhadeep Dutta Gupta, Shankaranarayana Rao BS, Bindu M Kutty. Ventral subiculum: Role in anxiety behavior. Proceedings 175. Sivakumar T, Thirthalli J, Chand PK, Arora S. Technology of International Conference on Neurodegenerative Diseases: enhanced learning in Psychiatric Rehabilitation: Virtual Pathogenesis to Therapy. Centre for Brain Research, Indian Knowledge Network (VKN) NIMHANS ECHO road to Institute of Science, Bengaluru, India. 16-18 November 2015. recovery. World Psychiatric Association Regional Congress 2015, Kochi. 25-27 September 2015. 183. Sujan MU, Babina Rao NM, Raju TR, Nalini A, Sathyaprabha TN, Raghavendra R. Effect of pranayama & relaxation 176. Sivakumar T. (i) Challenges unique to persons with mental illness technique (Yoga Therapy) on migraine: A clinical & autonomic for education for sustainable development. 2nd International function study. 17th Congress of the International Headache conference on Education for Sustainable Development: Society- IHC 2015, Valencia, Spain, 14-17 May 2015. Empowering Individuals with Multiple Disabilities, New Delhi, 27-28 February 2016 (ii) Daycare and role in postgraduate 184. Sunil Jamuna Tripathi, Suwarna Chakraborty, Srikumar BN, training in NIMHANS. 3rd Nitte International Conference and Raju TR, Shankaranarayana Rao BS. Transient inactivation of Workshop 2015, Nitte, Mangalore, 27-28 November 2015 (iii) basolateral amygdala prevents chronic stress-induced regressive Psychiatric rehabilitation: Experiences from India. Symposium plasticity in the prefrontal cortex: A behavioral, morphological on Rehabilitation in Resource-Poor Setting: Experiences from and molecular study. Proceedings of International Conference South East Asia. World Psychiatric Association Regional on Neurodegenerative Diseases: Pathogenesis to Therapy. Congress 2015, Kochi. 25-27 September 2015. Centre for Brain Research, Indian Institute of Science, Bengaluru, India. 16-18 November 2015. 177. Soundarya Soundararajan. Alcohol craving prior and following detoxification in patients with alcohol dependence- A pilot 185. Supraja TA, Kavita V Jangam, Geetha Desai, Satyanarayana study from South India. Gordon Research Conferences on VA, Thennarasu K, Latha Venkatram, Aruna Muralidhar, Alcohol and Nervous System, Galveston, Texas, USA, 7-12 Prabha S Chandra. Perception of social support and maternal February 2016. mood during pregnancy. International Conference on Gender Equality (ICGE-1-2015), 12-14 November 2015. 178. Sowmyashree MK, Sonia B, Rose DB, Venkatasubramanian G, Girimaji SC, Srinath S. Higher dose of general anaesthetics 186. Sukanya Baruah, Sundar Periyavan, Sangeetha SK. required for sedation in children with autism spectrum disorder Complications of therapeutic plasmapheresis in neurological compared to neuro-atypical controls. 1st Asia Pacific Regional patients in a tertiary neurosciences institute. 56th Annual IMFAR, Shanghai, China, November 2015. Conference of Haematology and Blood Transfusion (Hematocon 2015), Bengaluru, 5-8 November 2015. 179. Srikala Bharath. (i) Empowering adolescents with life skills- A promotional approach to the school mental health program. 187. Suwarna Chakraborty, Sunil Jamuna Tripathi, Srikumar
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BN, Raju TR, Shankaranarayana Rao BS. N-Acetyl cysteine Conference on Clinical Microbiology and Microbial Genomics, treatment ameliorates depression-induced cognitive deficits. Philadelphia, 5-7 October 2015. Proceedings of International Conference on Neurodegenerative Diseases: Pathogenesis to Therapy. Centre for Brain Research, 195. Veenakumari HB, Sruthy Sasidharan, Priya J, Nagarathna S. Indian Institute of Science, Bengaluru, India. 16-18 November Prevalence of methicillin resistant staphylococcus aureus and 2015. coagulase negative staphylococci bacteremia and nasal carriage in a tertiary care hospital, South India. 17th International 188. Jaisoorya TS, Badamath S, Syamsundar A. Heterogeneity Conference on Infectious Diseases, Hyderabad, 2-5 March 2016. of OCD. WPA Regional Conference, Kochi, India, 25 -27 September 2015. 196. Velmurugan Jayabal. (i) Pre-ictal and ictal pathological high frequency oscillations in drug resistant epilepsy: Analysis 189. Tanakanti Sreedhar, Birudu Raju, Srikanth Reddy V. A cross of MEG recording. American Epilepsy Society Meeting, sectional study on Perceived stress and perceives social support Philadelphia, USA, 2-6 December 2015 (ii) Characteristics among children suffering with mute and hearing impairment. of inter-ictal and ictal high frequency oscillations in patients International Conference on Community Mental Health: with absence epilepsy. 2nd International Workshop on HFOs in Trends and Challenges (ICCMH), Bengaluru, India, 11-12 epilepsy in Freiburg, Germany, 9-12 March 2016. December 2015. 197. Vidyadhara DJ, Yarreiphang H, Raju TR, Phalguni Anand 190. Tumuluri I, Hegde S, Nagendra. HR. (i) Music based Alladi. (i) Admixing of two mice strains with differential intervention to target stress and cognitive dysfunction in type susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 2 diabetes. 9th Triennial Conference of the European Society (MPTP) positively modulates the nigral dopaminergic for the Cognitive Sciences of Music, Manchester, UK, 17-22 phenotype. 45th Annual Meeting of Society for Neuroscience, August 2015. (Awarded 1340£ by the Society for Education, Chicago, USA, 17-21 October 2015 (ii) Effect of crossing Music and Psychology Research, UK.) (ii) Active music two mice strains with differential susceptibility to 1-Methyl- therapy to reduce stress and enhance cognitive functions in type 4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) on Nigral 2 diabetes. 21st International Conference on Frontiers in Yoga Dopaminergic Phenotype. International Conference of Research and Its Applications, Prashanti Kutiram, International Neurodegenerative Diseases: Pathogenesis to Therapy. Indian Headquarters of Vivekananda Yoga Anusandhana Samsthana Institute of Sciences, Bengaluru, 16-18 November 2015. (S-VYASA), Bengaluru, 3-7 January 2016. 198. Vijaya Kumar K, Raju TR, BS Shankaranarayana Rao. 191. Umesh Kumar, Ravi Yadav, Naveen Kumar C, Guru S Gowda, Celastrus paniculatus treatment prevents hypobaric hypoxia Srinivas Dwarakanath, Rose Dawn Bharath, Suresh Bada Math. induced oxidative stress and cognitive deficits. Proceedings Spectrum of unknown patients presenting to neuro-casualty of International Conference on Neurodegenerative Diseases: at tertiary care neuropsychiatric institute in South India. 5th Pathogenesis to Therapy. Centre for Brain Research, Indian International Conference on Neurology & Epidemiology, Institute of Science, Bengaluru, 16-18 November 2015. Griffith University, Parklands Drive, Gold Coast, Australia, 11 November 2015. 199. Vivek Benegal, Girish N. Anomie, drinking and harms to others in transition towns of India. KBS Thematic Meeting: 192. Vani Santosh. Critical role of IGFBP isoforms in glioblastoma Alcohol’s Harm to Others- Perceptions, Policies, Approaches. pathogenesis. 20th Annual Scientific Meeting of the Society for Helsinki, 14-17 September 2015. Neuro-Oncology, San Antonio, Texas, USA, 19-22 November 2015. 200. Vrinda M, Arun S, Srikumar BN, Bindu M Kutty, Shankaranarayana Rao BS. Combination therapy with 193. Varambally S. Yoga for severe mental disorders– New promise levetiracetam and enriched environment ameliorates temporal from an ancient science. 21st International Conference on lobe epilepsy-induced spontaneous recurrent seizures, Frontiers in Yoga Research and Its Applications (INCOFYRA), depressive behaviour and cognitive deficits. Proceedings of Bengaluru, 3–7 January 2016. International Conference on Neurodegenerative Diseases: Pathogenesis to Therapy. Centre for Brain Research, Indian 194. Veena Kumari HB, Priya Vijayan, Nagarathna S. Methicillin Institute of Science, Bengaluru, 16-18 November 2015. resistant staphylococcus aureus brain abscess- An overview in a tertiary neurocare centre in south India. 4th International 201. Yarreiphang H, Vidyadhara DJ, Raju TR, Phalguni Anand
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Alladi. Differential developmental apoptosis and apoptotic care as a rehabilitation tool. Symposium at ANCIPS, Bhopal, markers in 1-Methyl-4-Phenyl 1,2,3,6-Tetrahydropyridine Madhya Pradesh, 24 January 2016. (MPTP) resistant and susceptible mice strains and their crossbreds. 5th Asian and Oceanian Parkinson’s Disease and 8. Aier. A, Reddy PR, Rao NP, Rashmi, Kamaldeep. Movement Disorders Congress, Manila, 11-13 March 2016. Cognitive rehabilitation in post viral encephalitis sequelae. Neuropsychological Assessment and Rehabilitation: Roots to Fruits. NIMHANS, Bengaluru, 16- 18 July 2015. National Deliberations 9. Albert Stezin, Netravati M, Ravi Yadav, Pramod Kumar Pal. 1. Abhirami Visvanathan, Vikas Patil, Abhishek Natesh, Extrapyramidal features in Wilson’s disease: A comparative Alangar S Hegde, Bangalore A Chandramouli, Vani Santosh, study between tremor onsets versus dystonia onset variants. Arimappamagan Arivazhagan, Kumaravel Somasundaram. MDSICON 2016, Chennai, 8-10 January 2016. Caught in m6A-ction-Role of Epitranscriptome Modifier METTL3 in Glioblastoma Stem Cells. 8th RNA Group Meeting, 10. Amanpreet Kaur. (i) Mindfulness. Virtual Learning Centre CCMB Scientific Program, Hyderabad, 9 January 2016. (VLC), Centre for Addiction Medicine, Dept. of Psychiatry, NIMHANS, Bengaluru, 3 June 2015 (ii) Emotion Focused 2. Abhishek Lenka, Shaik Afsar Pasha, Sandhya Mangalore, Lija Therapy. 27 July, 4, 5 and 7 August 2015 (iii) CBT for social George, Ketan Jhujhunwala, Ravi Yadav, Jitender Saini, Pramod anxiety disorder. Behaviour Medicine Unit, 27-28 August (iv) Kumar Pal. Assessment of subclinical cerebellar dysfunction Three approaches to psychotherapy. 31 August, 4, 11, 21and in patients with progressive supranuclear palsy by SUIT based 23 September 2015 (v) CBT for sexual dysfunctions. Behaviour volumetry. 1st Annual Conference of the Movement Disorders Medicine Unit, 7-8 January 2016 (iv) Understanding cognition Society of India (MDSICON 2016), Chennai, 8-10 January 2016. and consciousness through music and meditation. 8 February 2016. Dept. of Clinical Psychology, NIMHANS, Bengaluru. 3. Abishek Lenka, Lija George, Ketan Jhunjhunwala, Shaik Afsar Pasha, Sandhya Mangalore, Jitender Saini, Netravathi 11. Ambika VS, Sailaxmi Gandhi. Descriptive study to explore M, Ravi Yadav, Pramod Kumar Pal. Assessment of cerebellar hospital epidemiology and consequences of post infection involvement in progressive supranuclear palsy using SUIT sciatic nerve injury. Satellite Conference of Neurotrauma based volumetric analysis. MDSICON 2016, Chennai, 8-10 Nursing 2015 and 24th Annual Conference of NTSI 2015, January 2016. NIMHANS, Bengaluru, 21-23 August 2015.
4. Adhin Bhaskar, Thennarasu K, Mariamma Philip, Jaisoorya TS. 12. Amey S. Preservation of labyrinthine structures while drilling A negative binomial regression approach to predict the number the posterior wall of the internal auditory canal in surgery of of harms due to others’ drinking among college students. vestibular schwannomas via the retro sigmoid sub occipital The International Biometric Society - Indian Region (IBS - approach. Skullbasecon 2015, Bengaluru, 11-13 October 2015. IR) and Public Health Evidence South Asia (PHESA) Joint Conference on, Converging to Better Health with Statistical 13. Amita Kumari Bhagat, Manjunatha MV, Ravi Vasanthapuram, Methods, Manipal University, Manipal, 11-12 January 2016. Anita Desai. Co-circulation of dengue virus serotypes in Bangalore, Karnataka. 24th National Conference of Indian 5. Adhin Bhaskar, Thennarasu, K., Mariamma Philip. Modeling Virology Society (IVS), Shillong, Meghalaya, 8-10 October 2015. of zero truncated count data in biomedical research: A simulation approach. 33rd Annual Conference of Indian Society 14. Amudhan S Gururaj G. Child mental health – Kolar case study. for Medical Statistics, KLE University, Belagavi, 14-16 October Symposium of Child Mental Health in India: Catalyzing the 2015. Public Health Response, Centre for Public Health, NIMHANS Bengaluru, 18 January 2016. 6. Afsar M. Tests of planning and response inhibition in NIMHANS neuropsychology battery. Neuropsychological 15. Ananya Sinha. The scars from the past- childhood sexual abuse: CEN 2015, 5th National Workshop on Neuropsychological A case study. 13th Biennial Conference of Indian Association of Assessment and Neuropsychological Rehabilitation: Roots to Child and Adolescent Mental Health (IACAMCON), Pune, Fruits, NIMHANS, Bengaluru, 16-18 July 2015. 19-21 November 2015.
7. Agarwal AK, Sivakumar T, Krishna Prasad M, Dheeraj K. Day 16. Andrade C. (i) (a) Neuroplasticity as a mechanism of
280 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 antidepressant action. (b) The story of cognitive reserve. One day workshop, Behavioral and Neuroscience Academy Psychiatric Neuroscience: Two-Day Collaborative Event of India, Delhi, 10 January 2016 (xx) Inadequate use of depot between Virginia Commonwealth University, Richmond, antipsychotics in practice: Causes and concerns. Long-acting Virginia, USA and DY Patil Vidyapeeth, Pune, 10 June 2015 (ii) Novel Antipsychotics, Behavioral and Neuroscience Academy of Innovative treatments for schizophrenia. 1st Annual Conference India, Chandigarh, 7 February 2016 (xxi) Intranasal treatments of the Indian Psychiatric Society (Telengana), Warrangal, 13-14 in psychiatry. DY Patil Symposium on Recent Advances in June 2015 (iii) Antipsychotic adverse effects: learning from meta- Psychiatry, Mumbai, 13 February 2016 (xxii) Intranasal ketamine analyses. National Mid-Term CME, Indian Psychiatric Society, as a novel intervention in psychiatry. Workshop on Diagnosis and Nagpur, 1-2 August 2015 (iv) Advances in the mechanism of Treatment, Indian Association of Private Psychiatry (Gujarat), action of ECT. One-day Seminar on ECT and Brain Stimulation, Ahmedabad, 13 March 2016. Masina Hospital, Mumbai, 8 August 2015 (v) Importance of e-psychiatry for practising psychiatrists. Annual State 17. Anita Desai. Quality in a diagnostic virology laboratory. Conference, Indian Psychiatric Society (Kerala), Trivandrum, 21- 2nd Conference of the Consortium of Accredited Health 23 August 2015 (vi) Depot antipsychotics. Long-acting Novel Organisations (CAHOCON), Bengaluru, 19 March 2016. Antipsychotics, Behavioral and Neuroscience Academy of India, Chennai, 23 August 2015 (vii) Psychoanalysis and modern day 18. Anita Mahadevan. (i) Clinical discussant, CPC. Neurovision psychiatry. 10th Foundation Day Conference of Girindra Sekhar 2015, Medanta Medicity, Gurgaon, 10 May 2015 (ii) Learning Institute of Psychological Education and Research, Calcutta, 29 neuroscience through histology – An art or a science?. CME, August 2015 (viii) Depot antipsychotics: foresight rather than Department of Anatomy, BGS Global, Bengaluru, 27 May afterthought. Long-acting Novel Antipsychotics, Behavioral and 2015 (iii) Microbes versus microbiologists: Lessons from Neuroscience Academy of India, Mumbai, 30 August 2015 (ix) the clinic. Department of Microbiology, KS Hegde Medical Targets for drug development in Alzheimer’s disease. 11th Annual Academy, Mangalore, September 2015 (iv) Interpretation of National Conference of the Indian Association for Geriatric nerve biopsies. APCON 2015, Kochi, 3-6 December 2015 (v) Mental Health, Baroda, 11-13 September 2015 (x) SPARI Learning neuroscience from the master of all viruses. NPSICON, antidepressants. National Symposium: From Melancholia to Hyderabad, 19-20 December 2015 (vi) Neuropathology of Depression, Bombay, 19 September 2015 (xi) Mechanism of extratemporal epilepsy. 6th Annual Conference of Karnataka action of ECT. Workshop on Non-Invasive Brain Stimulation State Neurosciences Academy, Kalaburagi, 29-31 January in Psychiatry, NIMHANS, Bengaluru, 20 September 2015 (xii) 2016 (vii) Proteomic approaches to study neurobiological ECT for PTSD: Mechanisms, efficacy and a hypothesis for disorders. Workshop on Mass Spectrometry based Quantitative new directions (plenary lecture). Annual National Conference Proteomics for Beginners, Institute of Bioinformatics, of the Indian Psychiatric Society (North Zone), Srinagar, 3-4 Bangalore, 1-4 February 2016 (viii) Pathology of CP angle October 2015 (xiii) (a) Understanding meta-analysis: Workshop tumors, National CP Angle Symposium, Guntur, Andhra (b) Advances in ECT. 37th Annual Conference of the Indian Pradesh, 20-21 February 2016 (ix) Pathology discussant in Psychiatric Society, Central Zone, Mordabad, 10-11 October CPC, SHINE 2016, Institute of Neurology, Chennai, 26-28 2015 (xiv) Cognitive reserve: Implications for corporate mental February 2016 (x) Writing a scientific article for publication. health. 16th Annual National Conference of the Association Sri Devaraj Urs Academy of Higher Education and Research of Industrial Psychiatry of India, Mumbai, 28-29 November (SDUAHER), Kolar, 5 March 2016. 2015 (xv) How to write a research paper. One-day CME, Indian Psychiatric Society: Publications and Presentations, 19. Annie P John. A study to explore the attitude of college students Kolkata, 15 November 2015 (xvi) Inadequate use of depot towards helmet use. 24th Annual National Neuro Trauma antipsychotics in practice: Causes and concerns. Long-acting Conference, Dept. of Nursing, NIMHANS, Bengaluru, 21- 23 Novel Antipsychotics, Behavioral and Neuroscience Academy of August 2015. India, Nagpur, 22 November 2015 (xvii) ANOVA, ANCOVA, and Survival Analysis. Workshop on Statistics for Psychiatry 20. Anshu K, Kumaresan UD, Ajay KN, Bindu MK, Shoba S, and Psychopharmacology. 68th Annual National Conference Laxmi TR. (i) Assessment of active and passive attention of the Indian Psychiatric Society, Bhopal, 21-24 January 2016 processes in a prenatal valproate rat model of autism spectrum (xviii) Inflammatory mechanisms and anti-inflammatory disorder (poster presentation). National Conference on treatment in schizophrenia. Biological Psychiatry Symposium, Motherhood and Mental Health, NIMHANS, Bengaluru, 68th Annual National Conference of the Indian Psychiatric 31 October 2015 (ii) Multidimensional attentional deficits in Society, Bhopal, 21-24 January 2016 (xix) Refractory depression: autism spectrum disorder: An assessment of active and passive Management. The great depression: Biology and philosophy. attention processes in a rodent model. 33rd Annual Conference
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of Indian Academy of Neurosciences 2015, Chandigarh, Collaboration Paediatric Neuro-Oncology KMC accredited 31October - 2 November 2015. CME and Workshop, KMIO, Bengaluru, 25 July 2015 (iii) Intra operative electrocorticography in epilepsy surgery: Utility 21. Antony S, Pandian RD. Negotiation strategies for patient and safety of Dexmedetomidine. Interim Meeting of the World welfare. 34th Annual National Conference of the Indian Society Society for Stereotactic and Functional Neurosurgery, Mumbai, of Professional Social Work (ISPSW), Central University of 3-6 September 2015 (iv) Transcranial Approaches to Pituitary Rajasthan, 24-26 February 2016. Adenoma: When and How? Annual Conference of Skull Base surgery Society of India, Bangalore, 8-12 October 2015 (v) How 22. Anupam Gupta. (i) Comprehensive care: Translating disability do I do it? Posterior quadrant disconnection. 9th Asian Epilepsy in to ability. Monthly Academic Meeting, NIMHANS, Surgery Congress and 10th Indian Epilepsy School. Udaipur, Bengaluru, 20 May 2015 (ii) Assessment and injection of 23-25 October 2015 (vi) (a) Molecular characteristics of tumor botulinum toxin-A in post stroke spasticity in upper limbs infiltrating front in Glioblastoma: What have we learnt about using surface method. ISTART 2015, Mumbai, Maharashtra, molecular heterogeneity and implications on targeted therapy 25-26 July 2015 (iii) Locomotion and gait training in patients (b) Surgery for focal cortical dysplasias – overcoming challenges with SCI. National IAPMR mid-term CME, Srinagar, Jammu and improving the outcomes. NSICON 2015, 64th Annual and Kashmir, 18-20 September 2015 (iv) Locomotion and Conference of Neurological Society of India. Hyderabad, 16- gait training in patients with SCI: Things have changed for 20 December 2015. better in the last three decades. 5th Asian Australasian Society of Neurological Surgeons Neurotrauma Committee and 2nd 28. Arpita SD, Sunder P, Tyagi V, Kumar K, Thirthalli J, Kumar N, WFSN-Military Neurosurgeons Meeting, Jaipur, Rajasthan, Sunder S, Mehta U. Barriers in cognitive remediation therapy 9-11 October 2015. as an adjunctive treatment in patients with schizophrenia. Deliberations on Care delivery (DECADE) for Mental Illness in 23. Apeksha Sahu, Anita Mahadevan, Peeyush Prasad, Sreelakshmi Rural Communities, Thirthalli, Shivamogga, 12 December 2015. Sreenivasamurthy, Soujanya Yelamanchi, Gajanan Sathe, Gourav Dey, Manjunath Dammalli, Harsha Gowda, Akhilesh 29. Arumugham SS. (i) Transcranial magnetic stimulation. IPS- Pandey, Keshava Prasa TS, Shankar SK. Complexity of host SZ PG Training Program, Kottayam, 8-9 August 2015 (ii) response to HIV infection co-infected with cryptococcal TMS- Therapeutic principles and evidence. 1st Symposium meningitis, toxoplasma encephalitis and tuberculous meningitis. on non-invasive brain stimulation in psychiatry, Bengaluru, 20 NPSICON, Hyderabad, 19-20 December 2015. (Best Poster September 2015 (iii) Neuromodulation in obsessive compulsive Award: Infections Category) disorder. IPS-Andhra Pradesh State PG CME-2015, Visakhapatnam, 29 November 2015 (iv) Evidence base for 24. Arati S, Chetan GK, Dhananjaya I Bhat, Sibin MK. Association rTMS in psychiatric disorders. IPS-KC PG CME, Bengaluru, of apolipoprotein E and factor XIII gene polymorphism in November 2015. aneurysmal subarachnoid haemorrhage: A meta analysis, ISHG, Chennai, 3-5 March 2016. 30. Arvinda HR. (i) Imaging in spinal emergencies. CME on Emergency Radiology, Sri Devaraj Urs Medical College, 25. Aravind BA. Literature Search. Symposium on Writing Kolar, 21 August 2015 (ii) Carotico-cavernous fistula – My Dissertations for first-year PG Students of General Medicine, technique. First Annual Congress of Society of Therapeutic API Bhavan , Bengaluru, 26 July 2015. Neurointerventions. AVM – Evolutions of Techniques, Gurgaon, Delhi, 4-6 December (iii) Multi-modal evaluation of 26. Aravind Raj E, Nibin Paul P, Sherin Yohannan, Soyuz John, balloon occlusion test. 17th Annual Conference of Indian Society Elamurugu, Sukanya R, Sekar K. Psychosocial competencies of Neuroanaesthesiology and Critical Care, ISNACC 2016, among rural school children. 34th Annual National Conference NIMHANS, Bengaluru, 5-7 February 2016 (iv) Management of Indian Society of Professional Social Work, Central of Carotico-cavernous fistula. 18th Annual Conference of ISVIR University of Rajasthan, 24-26 February 2016. Navigation, Bengaluru, 18-21 February 2016 (v) Neuroimaging in brain tumours. Post graduate training programme for 27. Arivazhagan A. (i) Endoscopic management of multiloculated exam going students (GRASP), Ambedkar Medical College, hydrocephalus. 2nd Annual Conference of Neuro Endoscopy Bengaluru, 19 March 2016. Study Group of India and International Neuro Endoscopy Course, Bengaluru, 12-14 June 2015 (ii) Surgery for improving 31. Asma T, Jyoti SM, Roopesh BN. Effect of life skills intervention the outcomes of paediatric Brain Tumours. KMIO-TMC on self-concept and optimism of marginally intelligent students.
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42nd National Annual Conference of Indian Association of routine antenatal care? National Conference on Motherhood Clinical Psychologists, Imphal, Manipur, 24-27 February 2016. and Mental Health, NIMHANS, Bengaluru, 31 October 2015.
32. Athulya Jayakumar. Female sexual dysfunction: A Case 41. Bhola P. (i) (a) Framing ethical guidelines for counselling illustration. Workshop on Cognitive Behavioural Management professionals (b) Counsellor development and identity. of Sexual Dysfunctions, Dept. of Clinical Psychology, Counselling in India: A Practitioner’s Conference. Bangalore, NIMHANS, Bengaluru, 7-8 January 2016. 28-29 August 2015 (ii) Health psychology: working in a general hospital setting. Clinical Psychology: Promoting Mental 33. Ayushman Ghosh, Gayathri N, Madhusudana SN, Anita Health. An Orientation Programme for Postgraduate Students Desai. Ultrastructural changes in murine myoblast cells of Psychology. NIMHANS, Bengaluru, 5-6 February 2016 (iii) following Chikungunya virus infection. VIROCON, 24th Psychosocial Rehabilitation: recovery-oriented perspectives. National Conference of Indian Virological Society (IVS), 8-10 Clinical Psychology: Promoting Mental Health. An Orientation October 2015. Programme for Postgraduate Students of Psychology. NIMHANS, Bengaluru, 5-6 February 2016 (iv) Working 34. Banerjee D, Desai G, Chandra P. Hear me out: Experiences of in a multidisciplinary system: Roles and responsibilities of mothers suffering from severe mental illness with health care Psychiatric Rehabilitation Services team members. Workshop providers - A qualitative perspective. National Conference on on Nurses’ Role in Psychiatric Rehabilitation. NIMHANS, Motherhood and Mental Health, NIMHANS, Bengaluru, Bengaluru, 5 March 2016. 31October 2015 42. Bindu M Kutty. Brain and the concept of cognitive reserve. 35. Basava Kumar, Dinesh R, Arvind B A, Gautham MS. National Workshop on Achieving in Situ Functional Histology, Assessment of work stress and its associated factors among IIT Kharagpur, 21-22 March 2015. managerial staff in an apparel industry in Bengaluru. OCCUCON-2016, 66th Annual National Conference of 43. Bindu PS. Medical treatment of childhood epilepsies. Pediatric Indian Association of Occupational Health, Bengaluru, 19 Epilepsy Training Course-1(PET-1), Bengaluru, 4-6 March February 2016. 2016.
36. Baseema K, Hamza A, Chandra P, Pashapu DR, Ragesh 44. Binukumar B, Deepa M, Roopa S, Fatmi Z, Ajay VS, Ali G. Video feedback intervention to enhance mother-infant MK, Prabhakaran D, Tandon N, Mohan V, Narayan KMV. interaction: A feasibility study. National Conference on Does multiple imputation using chained equations efficient Motherhood and Mental Health, Bengaluru, 31 October 2015. for handling missing data in studies with large sample size? International Biometric Society Indian Region Conference, 37. Bhagya V, Mahati K, Raju TR, Shankaranarayana Rao (IBS- IR 2016), Manipal University, Udupi, 11-12 January BS. Innovative therapeutic stratergies to treat depression. 2016. National Symposium on Neuroscience on Recent Advances in Neuroscience and its Application in Medical Sciences, 45. Binukumar B, Jeemon P, Praveen PA, Ritvik A, Lakshmy R, Ravenshaw University, Cuttack, Odisha, 13-14 November Anand K, Roy A, Pandey RM, Cunningham S, Tandon N, 2015. Reddy KS, Prabhakaran D. A comparison of intra-cluster correlation coefficients of cardiovascular disease risk factors in 38. Bhat MD, Prasad C, Tiwari S, Chandra SR, Christopher R. urban, rural and Industrial populations in India. 33rd Annual Diffusion restriction in ethyl malonic encephalopathy - An Conference of Indian Society for Medical Statistics, KLE imaging evidence of the pathophysiology of the disease. 24th University, Belagavi, 14-16 October 2015. ISNR, Indore, 2015. 46. Birudu Raju, Krishna Reddy. Rehabilitation measures of 39. Bhat MD, Chandrajit Prasad, Netravathi M, Chandra persons with traumatic brain injury. 24th Annual Conference of SR, Vykuntaraju KN, Christopher R. Patterns of diffusion Neurotrauma, NIMHANS, Bengaluru, 21-23 August 2015. restriction in glutaric aciduria type 1. 69th IRIA, Bhubaneshwar, 21-24 January 2016. 47. Chakrabarti D, Radhakrishnan M, Nitin M, Dheeraj M. Can superior sagittal sinus density predict anaemia? Annual 40. Bhat S, Chandra PS, Desai G, Satyanarayana V, Jangam K. Conference of Neurotrauma Society of India, Bengaluru, 21-23 What do women feel about psychosocial assessments as part of August 2015.
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48. Chakrabarti D, Ramesh VJ, Deepti BS. BIS Artefact 55. Chandrajit Prasad. Neuroimaging in Neuro-metabolic compendium – Mechanisms explored. 17th Annual Conference disorders. SACRED-15 (MRI - Head to Toe) CME, Sri of ISNACC, Bengaluru, 5-7 February 2016. Sathya Sai Institute of Higher Medical Sciences, Bengaluru, 7-9 August 2015. 49. Chakrabarti D, Reddy KRM, Kamath S. Evaluation of dexmedetomidine as an anaesthetic adjunct to propofol during 56. Chandran D. (i) (a) Neuropsychological assessment (b) bispectral index guided anaesthesia for cerebello-pontine angle Cognitive retraining in hypoxic ischaemic encephalopathy: surgeries. 63rd Annual National Conference of Indian Society of A case study. 5th National Workshop on Neuropsychological Anaesthesiologists, Jaipur, 26-29 December 2015. Assessment and Rehabilitation: Roots to Fruits 2015 (NANR- RF 2015), Continuing Education in Neuropsychology (CEN), 50. Chakrabarti D, Rohini M Surve, Deepti BS. Intraoperative Clinical Neuropsychology Unit, Dept. of Clinical Psychology, aberrant bispectral index values due to facial nerve monitoring. NIMHANS, Bengaluru, 16-18 July 2015. Karnataka ISACON 2015, Bagalkot, October 2015. (First Prize for Poster Presentation). 57. Chandran D, Kumar JK. Executive functioning in mild cognitive impairment: Three case studies. 5th Asia-Pacific 51. Chand P. (i) (a) Pharmacotherapy of alcohol use disorders (b) Regional Conference on Psychosocial Rehabilitation, World Preparing next-gen addiction experts. CME on Addiction, Association for Psychosocial Rehabilitation, MS Ramaiah Kasturba Medical College, Mangalore, 20 June 2015 (ii) Clinical Medical College and Hospital, Bangalore, February 2015. interview for assessment and brief intervention, Workshop on NTCP (tobacco) and RNTCP (Tuberculosis) Ministry of 58. Chandrasekhar Sagar BK, Kalyani Kumari, Vijay K Kalia. Health, New Delhi, 22 June 2015 (iv) Non-pharmacological Combination effects of anti-cancer agents on Human management in substance use disorders, PSYCON, Command Glioblastoma explant culture - An ultra-structural study. 33rd Hospital, Lucknow, 16 October 2015. Annual Conference of Indian Academy of Neurosciences on Advancing Neuroscience Research through Innovation, Panjab 52. Chandra PS. (i) Life has to be understood backwards - University, Chandigarh, 31 October-2 November 2015. Discoveries bridging women’s mental health and society. Dr. VN Bagadia Oration, Oracon 2015, Seth GS Medical College 59. Chaturvedi J, Bhaskar Rao M, Arivahagan A, Sinha S, and KEM Hospital, Mumbai, 19 August 2015. (ii) (a) Impact of Mahadevan A, Satishchandra P. Surgical outcome of focal perinatal mental health on pregnancy, fetal and infant outcomes. cortical dysplasia. WSSFN Interim Meeting, Mumbai, 6 (b) Improving mental health and resilience in perinatal mental September 2015. health. National Conference on Motherhood and Mental Health, NIMHANS, Bengaluru, 31 October 2015 (iii) Identifying key 60. Chaturvedi SK. The year in mental health. Diabetes and domains of health-related quality of life for patients with chronic Depression CME, Bengaluru, 12 July 2015. mental illnesses. Symposium on Quality of Life in Chronic Mental Illnesses: Exploring New Frontiers, NIMHANS, 61. Chaturvedi SK, Angothu H. Advancements in the civic Bengaluru, 30 January 2016 (iii) Perinatal Psychiatry in the 21st and legal rights of caregivers; with special focus on the last Century. CME on Psychiatry in General Hospital Setting- Scope decade. National Conference of Indian Association for Social and Current Trends, Dept. of Psychiatry, BGS Global Institute Psychiatry, Agra, 6-8 November 2015. of Medical Sciences, Bengaluru, February 2016. 62. Chetan GK. Quantification of MGMT promoter methylation 53. Chandra SR, (i) Approach to clinical diagnosis and differential and hTERT expression in malignant glioma: Exploring the diagnosis of dementia, TSS-NIMHANS, Knowledge Conclave correlation. 41st Indian Society of Human Genetics, Chennai, 2016, Bangalore, 12-13 February 2016 (ii) Parietal Lobe. 3-5 March 2016. Neuropsychology Workshop NSIKC, Trivandrum, India, 28 February 2016 (iii) (a) Parietal lobe: Clinical case discussion. 63. Chiplunkar S, Sonam K, Bindu PS, Taly AB, Gayathri N, SHINE, Chennai, 7-9 March 2016. Srinivas Bharath MM, Nagappa M, Kumar R, Sinha S, Arvinda HR, Govindaraj P, Paramsivam A, Thangaraj K. Mitochondrial 54. Chandra SR, Kiran Kumar, Rose Dawn. A study of correlation disorders due to polymerase gamma 2 (POLG2) mutations: between anatomical, electrophysiological and functional A phenotypic, biochemical and histopathological study. 23rd parameters in cortical dementias. TSS-NIMHANS, Knowledge Annual Conference of the Indian Academy of Neurology Conclave 2016, NIMHANS, Bengaluru, 12-13 February 2016 (IANCON), Agra, 1-4 October 2015.
284 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
64. Chithira S, Ravi SK, Vandana VP. Adaptation and validation Conference of Indian Virological Society, NEIGRIHMS, of action naming test in Malayalam. 8th Kerala ISHACON, Shillong, Meghalaya, India, 8-10 October 2015. Wayanad, Kerala, 12-13 September 2015. 69. Deepthi K, Suman LN. Normative beliefs, alcohol salience and 65. Chitra Chandran, Anita Mahadevan, Saini J, Satishchandra alcohol use among Bangalore college students. 42nd National P, Shankar SK. Movement disorders in cerebral toxoplasmosis Annual Conference of the Indian Association of Clinical – A postmortem neuroanatomical correlation. NPSICON, Psychologists, Imphal, Manipur, 25-27 February 2016. Hyderabad, 19-20 December 2015. 70. Deepti BS, Dhritiman Chakrabarti, Radhakrishnan M. 66. Christopher R. (i) Application of tandem mass spectrometry in Intraoperative seizures detected as increased BIS values during the diagnosis of genetic disorders, CME on Molecular Genetics Cerebello-pontine surgeries. Karnataka ISACON 2015, for Practicing Clinicians, Mumbai, 19 April 2015 (ii) A Bagalkot. October 2015. biochemical approach to inborn errors of metabolism by dietary intervention. Centre for Human Genetics, Bengaluru, 18 May 71. Deepti BS, Dhritiman Chakrabarti, Radhakrishnan M. MRI 2015 (iii) Tandem mass spectrometry as a tool for identification predictors of Intraoperative bleeding in intracranial tumor surgery. of inborn errors of metabolism. 3rd State Conference of the 17th Annual Conference of ISNACC, 5-7 February 2016. Association of Medical Biochemists Karnataka Chapter, Bengaluru, 11-12 September 2015 (iv) Recent advances in 72. Deepti BS, Umamaheshwara Rao, Gopalakrishna KN, identification of inborn errors of metabolism. MVJ Medical Dhritiman Chakrabarti. A prospective study to compare effect of College and Research Hospital, 24 November 2015 (v) Tandem mannitol and 3% hypertonic saline on cerebral hemodynamics in mass spectrometry: From bench to bedside to improve patient head injury patients. 63rd Annual National Conference of Indian care. Bangalore Bio India 2016 Conference, Bengaluru, 9-11 Society of Anaesthesiologists, Jaipur, 26-29 December 2015. February 2016. 73. Deiva. A study to assess the effectiveness of coma stimulation 67. Deepak Jayarajan. (i) Alcohol use disorders; Benzodiazepine use therapy among traumatic brain injury patients, 24th Annual disorders; Opioid withdrawal; Networking referral and linkages. National Neuro trauma conference, Dept. of Nursing, Co-morbidity training Programme for OST/ TI staff, RTTC, NIMHANS, Bengaluru, 21- 23 August 2015. NIMHANS, 8-11 September 2015 (ii) Alcohol withdrawal and complications. Virtual Knowledge Network (VKN) NIMHANS 74. Desai G. (i) Psychotropics in Motherhood, CME on Women’s ECHO, Centre for Addiction Medicine, Department of Mental Health, Amala Institute of Medical Sciences, Thrissur, Psychiatry, 3 November 2015 (iii) Rehabilitation in substance use Kerala 12 April 2015 (ii) Psychotropics in Motherhood, disorders. Substance Abuse Treatment Orientation Programme CME on Women’s Mental Health, Udupi, 22 May 2015 (iii) (STOP), Centre for Addiction Medicine, Dept. of Psychiatry, Medically unexplained symptoms. World Mental Health 19 November 2015 (iv) Addiction and management: Alcohol/ Day, Mandya Institute of Medical Sciences, Mandya, 14 tobacco. Integrating management of neuropsychiatric problems October 2015 (iv) Emotional wellbeing and work life balance, into NCD care: Training programme for specialist doctors, MMSR Research Center, Bengaluru, 27 November 2015 (v) District Training Centre, Kolar, 29 November 2015 (v) Dealing Psychological aspects of chronic orfacial pain. CME on orfacial with alcohol and tobacco use. Caregivers’ Support and Education Pain, VS Dental College, Bengaluru, 11 February 2016. Programme Workshop, NIMHANS, Bengaluru, 29 December 2015 (vi) Assessment of quality of life. Workshop on Quality 75. Dey G, Rodrigues B, Madugundu AK, Gowda H, Pandey of Life in Chronic Mental Illnesses: Expressing New Frontiers, A , Mani R, Madhusudana SN, Shankar SK, Prasad TSK. NIMHANS, Bengaluru, 11 January 2016 (vii) Assessment and Repertoire of differentially expressed proteins in cerebrospinal management of alcohol/tobacco use in primary care. CME fluid of rabies survivor and non-survivor individuals. th7 Annual programme on Mental Health in Primary Care, General Meeting and Conference of Proteomics Society of India, VIT Hospital, Anekal, 27 February 2016 (viii) Mental Disability and University, Vellore, 3-6 December 2015. Assessment. National Workshop for Nurses’ Role in Psychiatric Rehabilitation Services, NIMHANS, Bengaluru, 5 March 2016. 76. Dhananjaya Bhat I. Gamma Knife for hemangiomas of cavernous sinus. Skull Base Con 2015, 17th Annual Conference of Skull 68. Deepashri Rao, Manjunatha MV, Ravi Vasanthapuram, Base Society of India 2015, Bengaluru, 9-11 October 2015. Satish Chandra P, Anita Desai. T cell subsets in HIV infected individuals with and without neurotuberculosis. 24th Annual 77. Dharmappa AS, Sundar P, Tyagi V, Thirthalli J, Kumar CN,
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Shyamsundar A, Mehta UM. Barries for cognitive remediation movement disorders – Where are we? 1st Annual Conference Therapy for Persons with schizophrenia. DECADE 2015 of the MDSI, Chennai, 9-10 January 2016 (vi) DBS in Conference, Thirthahalli, 12 December 2015. dystonia – A perspective. KNACON -2016, Kalaburgi, 30-31 January 2016. 78. Dheeraj Masapu, Umamaheswararao GS, Sanjib Sinha, Gopalakrishna KN. Comparison of propofol and midazolam 85. Gautham MS. (i) Disease control in workplaces: Changing in refractory status epilepticus. 17th Annual Conference of priorities from a public health perspective. National Conference ISNACC, 5-7 February 2016. (Consolation Prize) on Emerging Issues in Environment and Occupation Health and Safety (EOHS), Regional Occupational Health Centre, 79. Dheeraj Masapu, Radhakrishnan, Chakrabarti D, Nitin Bengaluru, 22-24 July 2015 (ii) Good practices in the preparation M. Evaluation of thiopentone requirement in head injured of quality research papers. CME on research and publications. patients. 63rd Annual National Conference of Indian Society MS Ramaiah University, Bengaluru, 4 December 2015 (iii) of Anaesthesiologists, Jaipur, 26-29 December 2015. (KOPS Making sense of occupational health data. OCCUCON-2016, Award). 66th Annual National Conference of Indian Association of Occupational Health, Bengaluru, 19 February 2016. 80. Dheeraj Masapu, Radhakrishnan, Chakrabarti D, Nitin M. Evaluation of precraniotomy and post craniotomy changes in 86. Gayathri N. Mitochondrial disorders with novel mutations. BIS in headinjury. Annual Conference of Neurotrauma Society 5th SMRM, Aravind Medical Research Foundation, Madurai, of India, Bengaluru, India, 21-23 August 2015. November 2015.
81. Dhruva Ithal, Geetha Desai, Prabha S Chandra. A community 87. Girimaji SC. (i) Intellectual disability in pre-schoolers. based prospective study of association between Restless Symposium on Early Identification and Response to leg syndrome and depression during Pregnancy. National Anganwadi Workers, CCAMH project of Dept. of Child Conference on Motherhood and Mental Health, NIMHANS, and Adolescent Psychiatry, NIMHANS, Bengaluru, 11 Bengaluru, 31 October 2015. August 2015 (ii) Syndromic approach to intellectual disability. IPSKC PGCME, Dharwad, 10 January 2016 82. Dorothy Paripoornam H, Sailaxmi Gandhi. Evidence based (iii) Helping children to cope with chronic physical illness: nursing practice in prevention of possible complications of a child psychiatrist’s perspective. 22nd Annual Conference cervical spine injury. Satellite Conference of Neurotrauma of Paediatric Orthopaedic Society of India (POSICON), Nursing 2015 with the 24th Annual Conference of NTSI 2015, Bengaluru, 22 January 2016 (iv) Approach to intellectual NIMHANS Bengaluru, 21-23 August 2015. disability, Workshop on Child and Adolescent Psychiatry, AFMC, Pune, 22 February 2016. 83. Dovih P, Mani RS, Ashwini MA, Chattopadhyay B, Garg K, Ramakrishnan U, Madhusudana SN. Communal hunting 88. Girish Kulkarni Baburao. (i) Management of neurological behavior in Nagaland creates risk of emerging infectious conditions. Workshop on Management of Mental Health, diseases. National Conference on Ethology and Evolution, Substance Use Disorders and Non Communicable Diseases in IISER, Mohali, 29 October - 1 November 2015. Workplaces, Dept. of Epidemiology, NIMHANS, Bengaluru, 7-10 July 2015 (ii) Fibromyalgia and other chronic pain, 2nd 84. Dwarakanth S. (i) Lesioning in tremor: How I do it? WSSFN Bangalore Neuro Update, Bengaluru, 28- 29 November 2015. 2015, Interim Meeting of the World Society for Functional and Stereotactic Neurosurgery, Mumbai, 3-6 September 89. Girish N. Epidemiology of common mental disorders. 2015 (ii) Surgical management of giant and large ACoA Professional Development Course, OCCUCON-2016, aneurysms. 15th Annual Conference of Cerebrovascular NIMHANS, Bengaluru, 17 February 2016. Society of India: Ludhiana, 18-20 September (iii) Importance of condylar preservation in far lateral approaches 90. Gope R. (i) Post translational modifications in human to anterior foramen magnum meningiomas. Skull Base Con cancer. Bangalore University Golden Jubilee Lecture Series 2015, 17th Annual Conference of Skull Base Society of India on Biology in the Genomic Era, Bengaluru, 15-16 April 2015 2015, Bengaluru, 9-11 October 2015 (iv) Importance of (ii) Dysregulated gene expression through post-translational condylar preservation in far lateral approaches to anterior modifications in human brain tumors. Science Academies’ foramen magnum meningiomas. 64th Annual Meeting of the Lecture Workshop on Recent Trends in Cellular Mechanisms NSI, Hyderabad, 17-20 December 2015 (v) Lesioning in and Gene Expression, St Joseph’s College, Bengaluru, 12
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February 2016 (iii) CRISPR-Cas9 system for targeted gene 96. Hamza A, Ragesh G, Sajitha K, Prasad R. Psychosocial editing: A revolutionary tool in molecular biology. National problems of patients with perinatal psychiatric disorders in Seminar on Frontiers in Biotechnology-NSFB-2016, Indian setting. 3rd Indian Social Work Conference 2015, Jain Bharathiar University, Coimbatore, Tamil Nadu, 18-19 Viswa Bharathi Institute, Ladnum, Rajasthan, 24 October - 26 February 2016. October 2015.
91. Gulshan Kumar, Arun Sasidharan, Ravindra PN, Sulekha 97. Hamza A, Ragesh G, Sajitha K. Tracing and reuniting with Sathiamma, Nirmala M, Ajay Nair, Ratna Jyothi, Bindu M Kutty. family of unknown mentally ill persons. Annual National Assessment of spindle delta dynamics of sleep architecture in Conference of Indian Society of Professional Social Work Vipassana Meditators: A neuroloop gain analysis. 33rd Annual (ISPSW), Rajasthan University, 24-26 February 2016. Conference of Indian Academy of Neurosciences, Punjab University, Chandigarh, 31 October - 2 November 2015. 98. Hareesh Angothu. (i) Common and severe mental illnesses. Volunteers Sensitization Programme, NIMHANS Centre for 92. Gupta A, Nageshkumar S, Taly AB. Neurological and Wellbeing, Bengaluru, 1 August 2015 (ii) Integrating mental functional recovery in acute transverse myelitis patients with health care and non-communicable disorders. Gulbenkian inpatient rehabilitation and Magnetic Resonance Imaging Global Mental Health Platform, NIMHANS, Bengaluru, Correlates. National IAPMR-midterm CME, Srinagar, 18- 13-15 November 2015 (iii) Workshop on quality of life in 20 September 2015. chronic mental illnesses: Exploring new frontiers. NIMHANS, Bangalore, 30 January 2016 (iv) Infrastructure and facilities 93. Gupta AK. (i) (a) Carotid and vertero – Basilar disease required for psychiatric rehabilitation services in a General – Case presentation (b) Live in Box – Case presentation Hospital, Workshop on Nurses Role in Psychiatric Rehabilitation (c) Management of Pial Fistulas. SAANVI 2016, Kolkata, Services, NIMHANS, Bengaluru, 5 March 2016. 9-10 April 2015 (ii) Neuro intervention complication case in box INF, Goa, 30 July - 2 August 2015 (iii) Indications 99. Hargun Ahluwalia Rajeswaran J, John JP. Efficacy of for neurointervention. Neurointervention Workshop, neuro-feedback training on the quality of life of patients NEUROVASCON 2015, Ludhiana, 18-20 September 2015 with schizophrenia. Neuropsychological CEN 2015, 5th (iv) SAH Trials: How it changes our practice. ISNR, Indore, National Workshop on Neuropsychological Assessment 8-11 October 2015 (v) Intervention pial arteriovenous fistulae: and Neuropsychological Rehabilitation: Roots to Fruits, Experience with endovascular embolization. NSI, Hyderabad, NIMHANS, Bengaluru, 16-18 July 2015. 17-20 December 2015 (vi) Endovascular management of pial AVM and AVF – curative to palliation, ISVIR 2016, 100. Harish T. Nattala Prasanthi. Facts about severe mental illness. Bengaluru, 18-21 January 2016 (vii) Interventions in acute Workshop on Promoting Dignity through Cognizance of Facts stroke: Current strategies. IRIA 2016, Bhubaneshwar, 21-23 about Mental Illness, 8 October 2015. January 2016 (viii) Sharma MK. Exploration of nomophobia among professionals at workplace. 68th ANCIPS, Bhopal, 101. Harish T. Psychotropics, Pregnancy and lactation. National Madhya Pradesh, 21-26 January 2016. Midterm CME of IPS, Nagpur, 1-2 August 2015.
94. Gururaj G, Amudhan S. Epidemiology of Child Mental 102. Harshitha SM, Sibin M K, Jeru Manoj M, Lavanya CH, Arati Health problems in India. Symposium of Child Mental Health S, Narasinga Rao KVL, Dhananjaya I Bhat, Chetan GK. Micro in India: Catalyzing the Public Health Response, NIMHANS, RNA 196A2 polymorphism (rs11614913) and its association Bengaluru, 18 January 2016. with the risk of Glioma in Indian population. ISHG, Chennai, 3-5 March 2016. 95. Gururaj G. (i) Road Safety among young people: Need for data driven and evidence based practices. 9th National Conference 103. Hegde S. Neuropsychology and neuropsychological rehabilitation: on Adolescent Health, Imphal, 13-15 March 2015 (ii) Road An overview. Clinical Psychology: Promoting Mental Health, traffic injuries – Prevalence, prevention, and medico legal Orientation Programme for Postgraduate Students of Psychology, issues. National Conference on Traumatic Brain Injury - A NIMHANS, Bengaluru, 5-6 February 2016. Multidisciplinary approach, Bangalore, 10 September 2015 (iii) Injury surveillance in work places and best practices in injury 104. Hirisave U. (i) Child sexual abuse: Intervention. Silver Jubilee prevention. 66th Annual Conference of Indian Association of Annual Conference, Indian Psychiatric Society, Assam State Occupational Health, Bengaluru, 17-19 February 2016. Branch, Guwahati, Assam, 21-22 July 2015 (ii) Child mental
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health issues: Developmental perspective. Workshop on Santosh, Kumavaravel Somasundaram. Epigenetically silenced Promoting Mental Health and Psychological Well Being gene GNG4 abrogates signaling through chemokine receptor of Adolescents Using Life Skills Approach. Department of CXCR4 thus leading to inhibition of GBM cell migration. Psychiatric Social Work, NIMHANS, Bengaluru, 7-8 September MCB75: from Molecules to Organisms Symposium, 2015 (iii) Preparing for the examination. Workshop on Prepare Hyderabad, 11-14 December 2015. for SSLC Examinations, Balavikasa Academy, Dharwad, Child Development and Women and Child Development Department, 111. James JW, Sivakumar T, Jagadhisha T, Kumar CN, Chetan Education Department, Sri Gangamma Hombegowda School, B, Sathish SV, Nithin K, Dayanand, Santhosh S, Gopinath Bengaluru, 17 February 2016. KN, Janardhana AL, Swaminathan G. (i) (a) Availability of psychotropic medication at primary health care (b) Cost of 105. Huddar A, Bindu PS, Nagappa M, Bharath RD, Sinha S, Taly providing treatment for persons with psychiatric disorders. AB. Opsoclonus Myoclonus Ataxia syndrome in children: Preliminary findings from Jagaluru CBR, Deliberations A retrospective study on cohort in tertiary care hospital in on Care Delivery (DECADE) for Mental illness in Rural India. IANCON 2015, Agra, 1-4 October 2015. (Best Paper Communities, Thirthahalli, 12 December 2015. Presentation Award). 112. Janardhanan C Narayanaswamy. (i) Neuroimaging in OCD- 106. Indira Devi B. Is cortical plasticity the cause and effect of State of Art. Behavioral and Neuroscience Academy of India dyesthetic pain in panbrachialplexeus injury? World Congress (BANAI) Meeting, Mumbai, 17 May 2015 (ii) Management of Brachial Plexus and Peripheral Nerve injury. New Delhi, 4-7 of OCD –Practical Considerations. Annual CME, KIMS, February 2016. Hubli, 14 June 2015 (iii) Neurobiological findings in obsessive compulsive disorder. Behavioral and Neuroscience 107. Indupriya B, Roopesh BN. Treatment of a child with behavioral Academy of India (BANAI) Meeting, Srinagar, 25 July problems and school refusal - a case study. 42nd National Annual 2015 (iv) Practical tips in the treatment of OCD. Kolkata Conference of Indian Association of Clinical Psychologists, Psychiatry Club, Kolkata, 27 July 2015 (v) tDCS in psychiatric Imphal, Manipur, 24-27 February 2016. disorders. South Zone CME, Kottayam, 8 August 2015 (vi) Practical demonstration of tDCS application. Non Invasive 108. Jagadisha Thirthalli. (i) ECT: Should we still use it? CME Brain Stimulation Symposium, NIMHANS, Bengaluru, on Old is Still Gold. Indian Psychiatric Society, Karnataka 20 September 2015 (vii) Neurobiological underpinnings of Chapter, Bengaluru, 20 June 2015 (ii) Cognitive adverse OCD. 4th IPS Andhra Pradesh State Postgraduate CME, effects of ECT. CME on ECT and Brain Stimulation in Visakhapatnam, 29 November 2015 (viii) tDCS in addictive Masina Hospital, Mumbai, 8 August 2015 (iii) ECT in Special disorders. Behavioral and Neuroscience Academy of India Populations. Workshop on Non-Invasive Brain Stimulation (BANAI) Meeting, Srinagar, 28 January 2016. (NIBS) in Psychiatry, NIMHANS, Bengaluru, 20 September 2015 (vi) ECT in special populations. Post Graduate Training 113. Joshi PG. (i) Signaling networks in the brain: Real time Programme of the Indian Psychiatric Society, Karnataka measurement of intra and intercellular signaling by Chapter, Bengaluru, 19-20 December 2015 (v) Reducing fluorescence imaging. National symposium on Medical treatment gap in mental illness in India: Looking beyond. The Biophysics, Savitribai Phule Pune University, Pune, 25-26 National Mental Health Program. Fogarty Annual Symposium September 2015 (ii) Astrocytic plasticity in epilepsy. 33rd Guwahati, 25-28 January 2016 (vi) Identifying key domains of Annual Conference of Indian Academy of Neurosciences, health-related quality of life for patients with chronic mental Punjab University, Chandigarh, 31 October-2 November illnesses. Workshop on Quality of Life in Chronic Mental 2015 (iii) Glutamate induced excitotoxicity in spinal neurons: Illnesses: Exploring New Frontiers, NIMHANS, Bengaluru, Implications for selective degeneration of motor neurons in 30 January 2016. amyotrophic lateral sclerosis, Ravenshaw University, Cuttack, 13-14 November 2015. 109. Jagannathan A, Reddy KS. Mobilizing Resources for Psychiatric Rehabilitation Services Involving Volunteers and NGO’s. 114. Kalpana SR, Bharath G, Christopher R, Manjunath CN. Workshop on Nurses Role in Psychiatric Rehabilitation Association of VKORC1 gene polymorphism (-1639G> A Services, NIMHANS, Bengaluru, 5 March 2016. and 1173C> T) and acenocoumarol maintenance dosage in patients with mechanical heart valve. 67th Annual Conference 110. Jagriti Pal, Vikas Patil, Baisakhi Mondal, Sudhanshu Shukla, of Cardiology Society of India (CSI), Chennai, 31 December Alangar S Hegde, Arimappamagan Arivazhagan, Vani 2015. (Special Award from Cardiology Society of India)
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115. Kandasamy A. (i) Training of Specialist doctors in integrating 122. Kaushik A Theerth, Tanmay Jadhav, Madhusudhan manageent of SUD with NCD. Kolar Observatory, Centre Reddy, Sriganesh Kamath. Cerebral oxygenation during for Public Health, NIMHANS, Bengaluru, 15 July 2015 (ii) electroconvulsive therapy. 17th Annual Conference of Indian Epidemiology of alcohol in India. Public Health and MNS Society of Neuroanaesthesia and Critical Care, NIMHANS, Disorders Symposium for Community Medicine Postgraduates, Bengaluru, 5 – 7 February 2016. (First Prize: Platform Paper Centre for Public Health, NIMHANS, Bengaluru, 23 August Presentation) 2015 (iii) Internet/ Mobile Addiction. CME on Addictive Disorders, PSYCON 2015, Lucknow, 16 October 2015 (iv) 123. Ketan Jhunjhunwala, Pramod Kumar Pal. A clinical profile of Psychopharmacology, Christ University, 25 November 2015 (v) patients with primary writing tremor. 1st Annual Conference of Psychiatrists are busy. How should they provide quality care for the Movement Disorders Society of India (MDSICON 2016), Alcohol Use Disorders? National Conference on Deliberations Chennai, 8-10 January 2016. on Care Delivery (DECADE) for Mental Illness among Rural Communities, Thirthahalli, Shivamogga, 12 December 2015 124. Kirtilaxmi KB. Brain abscess from isolated cerebral (vi) Inhalant use disorder. Behavioural and Neurosciences mucormycosis – A rare case report. Indian Association of Academy of India, Srinagar, Kashmir. 28 January 2016 (vii) Medical Microbiologists Karnataka Chapter, IAMM-KC Substance abuse in children and adolescents. National Institute Annual Conference (KC MICROCON 2016), BMCRI, of Public Cooperation and Child Development (NIPCCD), Bengaluru, 20 February 2016. Regional Centre, Bengaluru. 4 March 2016. 125. Kondapuram N, Nahar A, Desai G, Chandra P. Frequency 116. Kangkana B, Manjula M. Body esteem and psychological and clinical correlates of catatonia in post-partum psychosis. functioning in young adults. 42nd National Annual Conference National Conference on Motherhood and Mental Health, of IACP, Imphal, Manipur, 25-27 February 2016. (Best Paper NIMHANS, Bengaluru, 31 October 2015. Award) 126. Kowshik Kupatira, Gautham MS, Pradeep BS, Gururaj G. 117. Kanika Malik, Prabhat Kumar Chand, Marimuthu P, Suman Trends and risk for overweight and elevated blood pressure LN. Lifetime trauma experiences among women with alcohol among employees in TKML: A five-year record analysis (2010- use disorders. 16th CCPI National Conference on Trauma: 14). OCCUCON-2016, 66th Annual National Conference of Recovery and Growth through Counselling and Psychotherapy, Indian Association of Occupational Health, Bengaluru, 19 Sampurna Montfort College, Bangalore, 9-11 October 2015. February 2016. (Dr. Mahadevan Memorial Best Scientific Paper Award) 118. Kanitha D. Assessment of knowledge of multipurpose health worker regarding neurological birth trauma following difficult 127. Krishna Prasad M, Abhishek Pathak. Beyond assessment of delivery. 24th Annual National Conference of Neurotrauma quality of life in schizophrenia: Cultural, clinical and research Society of India, NIMHANS, Bengaluru, 21-23 August 2015 perspectives in the Indian context. Workshop on Quality of (3rd Prize for Paper Presentation). Life in Chronic Mental Illnesses: Exploring New Frontiers, NIMHANS, Bengaluru, 30 January 2016. 119. Kapanee ARM. Community mental health. Orientation Programme for PG students of psychology, Clinical Psychology: 128. Krishna Prasad M. (i) Disability assessment in mental illness. Promoting mental health, NIMHANS, Bengaluru, 6 February Half-day sensitization programme, for District Disabled 2016. Welfare Officers (DDWO’s) of Karnataka. NIMHANS Bengaluru, 15 December 2015 (ii) Acute and chronic nature 120. Kaushic A Theerth, Sudhir Venkataramaiah. Submandibular of mental illness. Workshop on Nurses’ Role in Psychiatric sialadenopathy following surgery in prone position. 63rd Annual Rehabilitation, NIMHANS, Bengaluru, 5 March 2016. Conference of Indian Society of Anaesthesiologists, Jaipur, 26- 29 December 2015. (Ish-Narani Best Poster Award) 129. Krishna Priya, Rahina A, Pradeep Y. Auditory temporal processing in mobile phone users. 8th Annual Conference of 121. Kavitha P, Sekar K. Psychosocial adjustment among children in Indian Speech and Hearing Association, Waynad, Kerala, 12- difficult circumstances (oral presentation), 34th Annual National 13 September 2015. Conference of the Indian Society of Professional Social Work (ISPSW), Central University of Rajasthan, 24-26 February 130. Krishna Reddy, Birudu Raju. (i) Working with families after 2016. head injury: A family centered approach. 3rd Indian Social
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Work Congress, National Association of Professional Social 134. Kumaresan UD, Kumari Anshu, Laxmi T Rao. Prenatal Workers in India and Department of Social Work, Jain Vishva exposure of Valproic Acid in rats: Effect on sleep architecture. Bharathi Institute, Ladnun, Rajasthan, 24-26 October 2015 APPICON 2015, AIIMS, Jodhpur, 26-28 November 2015. (ii) A review on mental health issues and social consequences of climate change a need for capacity building. 34th National 135. Kutty BM. (i) Sleep in schizophrenia: A window to understand Conference of Indian Society of Professional Social Work, the dysfunctional brain mechanisms, CME on Discovering Central University of Rajasthan, 24-26 February 2016. the Mystery of Sleep, APPICON-2015, AIIMS, Jodhpur, 26-28 November 2015 (ii) Importance of sleep: Clues from 131. Kulandaisamy A, Selvakumar M. Building resilience to prevent sleep deprivation studies. 10th National Sleep Medicine panic: Don’t Panic, Boost Yourself!. 2nd National Level Conference Course (NSMC 2015), Guwhati Medical College, Assam, 6-7 on Crunch in Psychiatric Nursing, Dept. of Mental Health December 2015 (iii) Implications of meditative practices on Nursing, ES College of Nursing, Tamil Nadu, 8 January 2016. cognition and brain cognitive reserve. Karnataka State Level Workshop on Cognitive Neuroscience and BCI, MS Ramaiah 132. Kumar CN. (i) ECT for Beginners. IPS south zone CME for Institute of Technology, Bengaluru, 14-21 January 2016. Psychiatry Post Graduate Students, Kottayam, August 2015 (ii) Outpatient based rehabilitation services. Symposium on 136. Lakshmanan S, Chand P, Das S, Arun K, Murthy P, Benegal Nuts and Bolts of Starting a Psychiatric Rehabilitation Centre, V, Anand A, Arora S. VKN NIMHANS ECHO: Bridging NIMHANS, Bengaluru, 19 September 2015 (iii) Legal issues the mhGAP: Capacity building with Coordinated Care in in the rehabilitation of homeless mentally ill. VKN Program on Addiction and Mental Health. Global Healthcare Summit Psychiatric Rehabilitation, NIMHANS, Bengaluru, October 2016, AIIMS, New Delhi, 29 December 2015-3 January 2015 (iv) (a) Basics of ECT (b) Insanity defence: Assessments. 2016. Post Graduate Training Program, NIMHANS, Bengaluru, 9-20 December 2015 (v) (a) Mental health policy of India: 137. Lakshmi J. Metacognitive therapy for social anxiety disorder. Glimpses from the past (b) Insanity defence: Assessments (c) Workshop on Cognitive Behavioral Therapy for Social Public health interventions for psychiatric disorders focussing Anxiety Disorder, Dept. of Clinical Psychology, NIMHANS, on schizophrenia: Is it time to rethink? (d) Caring psychiatric Bengaluru, 27-28 November 2015. patients in their own communities. Ground-level challenges. ANCIPS 2016, Bhopal, 21-24 January 2016 (vi) Prison mental 138. Lalitha K. (i) Introduction to mental health and positive health. VKN Program on Forensic Aspects of Addiction, mental health practice. Mental Health Enrichment Training NIMHANS, Bengaluru, March 2016. for Community, Differently Abled Welfare Facilitators of Pudhu Vaazhvu Project, NIMHANS, Bengaluru, 29 May 133. Kumar KJ. (i) Neuropsychological assessment and rehabilitation. and 17 June 2015 (ii) Geropsychiatric nursing as an initiative. 5th Continuing Education in Neuropsychology, National Versatile Advent-Mental Health Issues in Decrepit (senior Workshop, NIMHANS, Bengaluru, 16-18 July 2015 (ii) citizen) Inhabitants, State-level Conference 2015, Dhanvantri Rehabilitation: A functional neural network approach. Institute College of Nursing, Namakkal, 9 October 2015 (iii) Succession of Behavioural Science, Gujarat Forensic Science University, Planning. Nursing Conference on Care in Health Care Gandhinagar, Gujarat, 31 July-1 August 2015 (iii) Development NURCON-2015, Dr. LH Hiranandani Hospital, Mumbai, 17 of test batteries and interpretation of neuropsychological test October 2015 (iv) Communication of research findings. NRSI results: Effect of age and sociocultural norms; Construction and Conference, Mangalore. 29 October 2015 (v) Emerging trends motor performance; Disorder of perception. CME on Dementia, in health care – A holistic approach. National Conference Cognitive and Behavioural Neurology Section, Department on Emerging Trends in Health Care – A Holistic Approach, of Neurology, SCTIMST in collaboration with ARDSI, Dayananda Sagar College of Nursing, Bangalore, 8 December Trivandrum Chapter, Trivandrum, Kerala, 19 September 2015 2015 (iv) (a) Ethics in nursing (b) Role of nursing psychiatry. (iv) Cognitive testing in dementia-Indian Perspective. TSS- Short term training course for Nursing Personnel, Department NIMHANS Workshop on Cognition and Dementia Knowledge of Nursing Services, Mother Theresa Institute of Nursing, Conclaves 2016, An Interdisciplinary Workshop for Clinicians Puducherry, 14 March 2016. and Scientists, NIMHANS, Bengaluru, 12-13 February 2016 (v) Neuropsychological assessment and intervention in elderly. 139. Lavanya CH, Chetan GK, Sibin MK, Srinivas Bharath MM, UGC-DRS National Seminar on Healthy Aging: A Life Span Jeru Manoj. Down regulation of telomere reverse transcriptase Perspective, Department of Psychology, Sri Venkateswara (hTERT) expression by siRNA in Human glioblastoma LN18 University, Tirupati, 10-11 March 2016. cells. ISHG, Chennai, 3-5 March 2016.
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140. Lavanya TP, Ananya Sinha. (i) (a) Demonstration of the micro 2015 and 24th Annual Conference of NTSI 2015, NIMHANS, skills and group discussion (b) Do’s and Don’ts in counselling Bengaluru, 21-23 August 2015. and ethical practices. Workshop on Basic Skills for Counseling Youth. NIMHANS Centre for Wellbeing, Bengaluru, 7 148. Lydia Shanthakumari, Sailaxmi Gandhi. Oral care intervention November 2015. to reduce incidence of ventilator associated pneumonia patient with traumatic brain injury. Satellite Conference of 141. Lavanya TP, Manjula M. (i) Cognitive Behaviour Therapy in Neurotrauma Nursing 2015 with 24th Annual Conference a case of panic disorder. Workshop on Cognitive Behaviour of NTSI 2015, NIMHANS Bengaluru, 21-23 August 2015. Therapy: Principles and Applications, NIMHANS, Bengaluru, (Awarded First Prize). 9-10 July 2015 (ii) Interpersonal relationships with peers and siblings. Workshop on Maintaining Healthy Relationships for 149. Lydia Shanthakumari. (i) (a) Traumatic brain injury (b) Youth, NIMHANS Centre for Wellbeing, Bengaluru, 28 July Exhibits – Management of spinal cord Injury (c) Oral care 2015 (iii) Stress and its manifestations in students, causes of stress. intervention to reduce incidence of ventilator associated Workshop on Orientation to Mental Health Problems in Youth. pneumonia patient with traumatic brain injury. Satellite NIMHANS Centre for Wellbeing, Bengaluru, 29 August 2015. Conference of Neurotrauma Nursing 2015 with 24th Annual Conference of NTSI 2015, NIMHANS, Bengaluru, 21-23 142. Laxmi T Rao. (i) Childhood stress and its impact on sleep in August 2015. (Awarded First Prize) adulthood. CME on Recent Trends in Neuroanatomy and Neurophysiology, BGS Global institute of Medical Sciences, 150. Thomas Kishore M, Poornima Mahindru, G Ragesh, Prabha Bengaluru, 27 May 2015 (ii) Advancement of basic science Chandra, Geetha Desai, Harish T. Efficacy of DASII screen research in India. Awareness programme, Widia Poornaprajna in assessing the development of infants in perinatal psychiatry School, Bengaluru, 30 January 2016 (iii) Childhood stress setting. National Conference on Motherhood and Mental and mental health outcomes. Jain University, Bengaluru, 24 Health, NIMHANS, Bengaluru, 31 October, 2015. (Best February 2016. Poster Award)
143. Laxmi TR. Maltesh Kambali, Pradeep K. Mishra, Correlating 151. Mahesh J, Shree M, Shayanth M, Dayananda S, Virrappa P, impulsive behavior during adulthood to adverse childhood Aniruddh N, Jayanth M, Lekhansh S, Suhas G, Lakshmi R, experience. Symposium on Neuro-Cognition Functions, Kubenthiran N, Lakshmanan S, Deepak J, Arun K, Prabhat 61st Annual Conference of APPI, AIIMS, Jodhpur, 26-28 C, Pratima M, Vivek B, Mathew V, Arora S. Care delivery November 2015. (DECADE) for mental illness in rural communities. VKN NIMHANS ECHO: Addiction Mental Health, Thirthahalli, 144. Laxmi T Rao, Niharika Sane, Nesin Mathew, Sabitha K Rajesh. 12 December 2015. Constraint induced movement therapy (CIMT): Efficacy of rehabilitation intervention methods after ischemic stroke. 152. Maitreyi Patil. Quality of life, cognition and functional recovery National Symposium on Recent Advances in Neuroscience and in patients with Acquired Brain Injury following inpatient its Application on Medical Sciences, Ravenshaw University, rehabilitation. 44th IAPMRCON 2016, Imphal, Manipur, 12- Cuttack, Odisha, 13-14 November 2015. 14 February 2016. (IAPMR Dadhichi Award)
145. Leeshma BK. The effect of traumatic brain injury on cognitive 153. Majhi G, Reddy S, Muralidhar D. The use of family map and behavioural functions in adolescents. 24th Annual National (genogram) in psychiatric social work practice. 24th Annual Conference of Neurotrauma Society of India. NIMHANS, National Conference of the Indian Society of Professional Bengaluru, 21-23 August 2015. Social Work (ISPSW), Department of Social work, Central University of Rajasthan, Rajasthan, 24-26 February 2016. 146. Linsu Thomas, Sailaxmi Gandhi, Geetha Desai. Case report: Knowledge about mother-infant health in a mother with post- 154. Malla Bhaskar Rao. Epilepsy Surgery. Indo-Global Healthcare partum depression. National Conference on Motherhood and Summit and Expo 2015, Hyderabad, Telangana, 23-26 July 2015. Mental Health, MMH 2015, NIMHANS, Bengaluru, 31 October 2015. 155. Maltesh Kambali, Ravi Muddashetty, Laxmi T Rao. Impact of early life stress on remote fear memory in rats. National 147. Linsu Thomas, Sailaxmi Gandhi, Jisha, Geetha Desai. Battered Conference on Motherhood and Mental Health, MMH 2015, baby syndrome. Satellite Conference of Neurotrauma Nursing NIMHANS, Bengaluru, 31 October 2015.
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156.. Mangalore S. Radiological findings in children with autism, is 2015 (vii) Developing resilience. Workshop on Developing it a good tool to use. Indian Federation of Neuro Rehabilitation Resilience. SSMRV College, Bengaluru, 28 September 2015 (viii) and Neuro Rehabilitation Conference, NIMHANS, Bengaluru, Basic skills of interviewing (b) Communicating with teachers 1-3 April 2016. and parents. Workshop on Basic Skills for Counseling Youth, NCWB, Bengaluru, 7 November 2015 (ix) Stress management. 157. Mani RS. (i) Emerging viral threats: A ticking time bomb? Orientation Programme on Substance Use Disorders, The Indian Scenario. Quality Improvement Programme on Centre for Addiction Medicine, NIMHANS, Bengaluru, 13 Biotechnology in Health Care, Christ University, Bengaluru, November 2015 (x) (a) Managing emotions (b) Relationship 15 April 2015 (ii) Emerging viral diseases. Life Science issues and intergenerational connect. Training Session for Association, Christ University, Bengaluru, 18 June 2015 (iii) Yuva Parivarthakas, Dept. of Epidemiology, NIMHANS, ‘MERS’. CME/Post Graduate Lecture Series, Department of Bengaluru, 16-20 November 2015 and 25-27 January 2016 (xi) Microbiology, Rajarajeswari Medical College and Hospital, (a) Clinical challenges (factors impacting treatment response) (b) Bengaluru, 21 August 2015 (iv) Science and utility of real-time Cognitive behavioural assessment in social anxiety disorder (c) PCR. National Level Conference on Advanced Research in Behavioural strategies in managing social anxiety: role of applied Medical Science and Workshop, Department of Microbiology, relaxation, social skills training and graded exposure. Cognitive SRM Medical College Hospital and Research Centre, Chennai, Behaviour Therapy for Social Anxiety Disorder, Dept. of 28-29 September 2015 (v) Surveillance for bat rabies in India. Clinical Psychology NIMHANS, Bengaluru, 27-28 November 24th National Conference of the Indian Virological Society 2015 (xii) (a) Approaches to sex therapy – Other methods of – VIROCON 2015, NEIGRIHMS, Shillong, Meghalaya, therapy (b) History taking in Sexual Dysfunctions. Workshop 8-10 October 2015 (vi) Laboratory diagnosis of rabies. Rabies on Cognitive Behaviour Therapy in Sexual Dysfunctions, Dept. Symposium, Annual Conference of the Indian Association of Clinical Psychology, NIMHANS, Bengaluru, 7-8 January of Medical Microbiologists (MICROCON), JIPMER, 2016 (xiii) Common mental health problems in students. Puducherry, 27-29 November 2015 (vii) Confronting the micro- Faculty Development Programme, Jain University, Bengaluru, 16 terrorists: Viruses-the global travellers. Quality Improvement January 2016 (xiv) Principles and practice of counseling. Training Programme for Faculty of Life Sciences Department, Christ of Counselors under the National Programme for Prevention University, Bengaluru, 28 March 2016. and Control of Cancer, Diabetes, Cardiovascular diseases and Stroke (NPCDCS), Department of Epidemiology, NIMHANS, 158. Manjula M, Roopesh BN, Mariamma Philip. Depression, Bengaluru, 29-30 March 2016 (xv) Third wave behavior suicidal behaviors and stress coping in urban youth: An therapies. Workshop on Clinical Psychology: Promoting Mental exploratory study. 42nd National Annual Conference of IACP, Health. NIMHANS, Bengaluru, 5-6 February 2016. Imphal, Manipur, 25-27 February 2016. (Best Paper Award) 160. Manjunath M, Ketan Jhunjhunwala, Jafar A, Pratibha Surathi, 159. Manjula M. (i) (a) Essentials of interpersonal relationships Abhishek Lenka, Ravi Yadav, Dwarkanath Srinivas, Manish (b) Handling romantic relationships. Maintaining Healthy Ranjan, Arivazhagan A, Nethravathi M, Pramod Kumar Pal. Relationship – A workshop for Youth, NCWB, Bengaluru, Experience of pallidal deep brain stimulation in dystonia at a 4 July 2015 (ii) Counseling skills and strategies. Management tertiary care centre in India. MDSICON 2016, Chennai, 8-10 of Mental, Substance Use Disorders and Non Communicable January 2016. Diseases in Workplaces. Centre for Public Health, Department of Epidemiology, NIMHANS, Bengaluru, 7 -10 July 2015 (iii) 161. Manjunatha N, Reddy S, Kumar CN, Thirthalli J. Prevalence (a) Behavioural strategies in cognitive behaviour therapy (b) and its correlates of delusional procreation syndrome in a Cognitive Behavioural Analysis and formulation (c) Cognitive community sample. Conference on Deliberations on Care Behavioural Model of Depression. Workshop on Cognitive Delivery (DECADE) for Mental Illness in Rural Communities. Behaviour Therapy: Principles and Applications, Dept. of Commemorating a Decade of Service Based Research in Clinical Psychology, NIMHANS, Bengaluru, 9-10 July 2015 (iv) Thirthahalli, Thirthahalli, 12 December 2015. (a) Common mental health disorders in youth and its impact (b) Mood disorders in youth. Workshop on Orientation to Mental 162. Manjunatha N, Singh G. Evaluation of satisfaction of patients Health Problems in Youth, NCWB, Bengaluru, 1 August 2015 and their family members consulting community mental health (v) Enhancing mental wellbeing in youth: Effective Methods care. IPS NZ Conference, Srinagar, 3-4 October 2015. and Practice. Liberal Arts Department, IIT, Hyderabad, 25 August 2015 (vi) Self-awareness and acceptance. Workshop on 163. Manjunatha N. (i) Mental health, problems, strategies and Understanding Self, SSMRV College, Bengaluru, 18 September program and tobacco cessation and related activities. Training
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Program of NPCDCS and NPHCE, State Institute of 170. Meera SS, Dadlani N, Swaminathan D, D’souza C, Seles N, Health and Family Welfare, Bengaluru, 11 September 2015. Pillai A, Shivashankar N. Cognitive-linguistic intervention in (ii) CMDs. CME on Public Health Perspectives in Mental, a patient with Traumatic Brain Injury – A one year follow-up Neurological and Substance Use Disorders and Injuries, Dept. study. National Conference on Traumatic Brain Injury – A of Epidemiology, NIMHANS, Bengaluru 23 September 2015 Multi-Disciplinary Approach. Dr. SR Chandrasekhar Institute (iii) Tobacco cessation research in dentistry: Review from of Speech and Hearing (Dr. SRCISH), Bengaluru, 10-11 Indian publication. 69th Indian Dental Association, Delhi, 19- September 2015. 21 February 2016 (iv) (a) Presenting complaints of common mental disorders at primary care (b) Clinical features and 171. Meera SS, Girimaji AS, Jacob N, Pandey R, Ravi GS, Shivashankar diagnosis of anxiety disorders at primary care (c) Management N. Delineating regression from vocabulary loss in Autism Spectrum of CMDs at primary care. CME, General Hospital, Bengaluru, Disorders – A clinical perspective. 48th Indian Speech and Hearing 27 February 2016 and 19 March 2016. Association Conference, Mumbai, 5-7 February 2016.
164. Maria Thomas, Reeta Mani, Anita Desai, Ravi 172. Mehta UM, Thirthalli J. (i) (a) Electroconvulsive therapy Basic Vasanthapuram. Comparison of cytokine/chemokine profiles principles and standards of delivery (b) Electroconvulsive therapy in Influenza A (H1N1) pdm09 and seasonal H3 cases and in special populations (c) Evidence base for ECT in Psychiatric its correlation with disease severity. 24th Annual Conference disorders (e) cognitive adverse effects with ECT and measures of Indian Virological Society, NEIGRIHMS, Shillong, to minimize them (f ) Transcranial magnetic stimulation basic Meghalaya, 8-10 October 2015. principles and standards of delivery (g) Transcranial magnetic stimulation evidence base in psychiatric disorders (h) recent 165. Marimuthu P. Effect of socio-economic differentials on growth advances in brain stimulations for psychiatric disorders. CME and development of children from five metropolitan cities of on Electroconvulsive therapy and Other Neuro-stimulation India. Demographics – Dividend or Disaster. Jain University. Therapies, Goa Psyciayric Society, Goa, 25 October 2015. Bangalore, 29-30 January 2016. 173. Mehta UM. (i) Novel treatment modalities in psychiatry – 166. Meeka Khanna. (i) Neurogenic bladder after spinal cord injury. Brain stimulation. Maharashtra State Chapter Conference, Symposium on Bladder, Bowel and Sexual Dysfunction after Mahabaleshwar, 25-26 April 2015 (ii) Transcranial magnetic Spinal Cord Injury, Neurotrauma 2015, 24th Annual National stimulation – Basic principles and investigational use. 1st Conference of NeuroTrauma Society of India, NIMHANS, Symposium on Non-invasive Brain Stimulation (NIBS) in Bengaluru, 21-23 August 2015 (ii) Pulmonary involvement Psychiatry, Bengaluru, 20 September 2015. in patients with Guillain-Barré syndrome in subacute phase. PMRCON 2016, New Delhi, 5-6 March 2016. 174. Muralidhar D. Application of earth science knowledge in social adversaries. 34th Annual National Conference of the 167. Meena KS, Nattala P, Kapanee ARM, Loganathan S, Indian Society of Professional Social Work (ISPSW), Central Varghese M. Harnessing the potential of audio visual media University of Rajasthan, 24-26 February 2016. for mental health care. 68th Annual National Conference of Indian Psychiatric Society, Bhopal, Madhya Pradesh, 21-24 175. Muralidharan K. (i) Mood stabilization/prophylaxis: January 2016. Challenges in relapse prevention in bipolar disorder. BANAI, Ahmedabad, Gujarat, 23August 2015 (ii) Recent advances 168. Meera SS, Nidhi Jacob, Rachita Pandey, Akhila Srinath in brain stimulation. NIBS 2015 — 1st Symposium on Non- Girimaji, Ravi GS, Shivashankar N. Delineating regression Invasive Brain Stimulation (NIBS) in Psychiatry, NIMHANS, from vocabulary loss in Autism Spectrum Disorders: A clinical Bengaluru, 20 September 2015. perspective. 48th Annual Convention of Indian Speech and Hearing Association, Kokilaben Hospital, Mumbai, 5-7 176. Murugappan NP. (i) Trauma in schools. 16th National Conference February 2016. of CCPI, Bengaluru, 9 October 2015 (ii) Child and adolescent mental health. An Orientation Programme for Postgraduate 169. Meera SS, Asokan S, Ravi GS, Shivashankar N. Inclen Students of Psychology on Clinical Psychology: Promoting Diagnostic tool for the assessment of Autism Spectrum Mental Health, NIMHANS, Bengaluru, 5-6 February 2016. Disorders (INDT-ASD) – A new tool in the clinician’s armory. 48th Indian Speech and Hearing Association Conference, 177. Mythili D, Sailaxmi Gandhi, Padmavathy N, Helmet use Mumbai, 5-7 February 2016. experiences and attitudes among college students. Satellite
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Conference of Neurotrauma Nursing 2015 and the 24th Annual Society, Bhopal, 21- 24 January 2016. Conference of NTSI 2015, NIMHANS, Bengaluru, 21-23 August 2015. 186. Nattala Prasanthi, Harish T, Meena KS, Kalaivani PL, Emily Veena, Lydia Jeevan. Promoting positive interactions 178. Mythri R, Raghunath N, Srinivas Bharath MM. Transcriptomic with a mentally ill family member. Workshop on Promoting analysis of MPP+ induced neurotoxicity in dopaminergic Dignity through Cognizance of Facts about Mental Illness, neurons: Focus on oxidative stress and mitochondrial pathways, NIMHANS, Bengaluru, 8 October 2015. 29th Annual Meeting of the Society for Neurochemistry, India and National Workshop and Conference on Advances in 187. Nattala Prasanthi, Murthy Pratima, Ramakrishna Jayashree, Computational Neurochemistry and Neurobiology (SNCI- Leung KS, Rentala S. Harnessing the potential of audio visual ACNN 2015), North Eastern Hill University (NEHU), media for long-term management of alcohol Dependence. 68 Shillong, Meghalaya, 19-21 December 2015. ANCIPS, Bhopal, 24 January 2016.
179. Nagaraj C, Mangalore S, Gupta AK, Neurodegenerative 188. Nattala Prasanthi, Murthy Pratima, Ramakrishna Jayashree, diseases – A sneak peek with simultaneous pet MRI. 2nd T.S. Leung KS, Rentala S. NAVAJEEVANA: Video-enabled Srinivasan-NIMHANS Knowledge Conclave on Cognition Interactive relapse prevention intervention in alcohol and Dementia, NIMHANS, Bengaluru, 12-13 February 2016. dependence. Global Mental Health Summit, Mumbai, 29 November 2015. 180. Nagarathna S, Netravathi M, Veenakumari HB, Shayanki Lahiri Mukyopadhay, Sayani Maji, Satishchandra P. In vitro antifungal 189. Nattala Prasanthi. (i) (a) Role of schools in managing susceptibility of cryptococcus spp isolated from cases of cryptococcal children with developmental delay. Workshop on Role of meningitis. 39th National Conference of the Indian Association School Teachers in Classroom Management of Childhood of the Indian Medical Microbiologists (MICROCON 2015), Emotional, Developmental and Behavioral Problems, 13 JIPMER, Pondicherry, 2529 November 2015. April 2015 (b) Overview of community mental health programs in India. Workshop on Community Mental Health 181. Nagarjun MN, Arivazhagan A, Jagathlal, Sampath S, Vani Nursing, 21 November 2015 (c) Interpersonal relationships Santosh. Molecular stratification of pediatric infratentorial and interpersonal theories. Panel Discussion on Interpersonal ependymomas: correlation with clinical parameters. 64th Annual Relationships and Communication, 25 November 2015, Dept. conference of NSI, Hyderabad, December 2015. of Nursing, NIMHANS, Bengaluru (ii) Use of addictive drugs: What the youth needs to know. Symposium for Undergraduate 182. Nandeesh BN. (i) (a) Pediatric tumors of CNS (b) Skull base tumors. and Graduate College Students, BNES College, Bengaluru, PathFest Symposium Series. St. Martha’s Hospital, Bengaluru, 3 October 2015 (iii) Role of family in relapse prevention for August 2015 (ii) Quality control in pathology Laboratory. CME in alcohol use disorders. Deaddiction Treatment Program for Pathology and Blood Transfusion, Sri. Venkateshwara Institute of Doctors and Counselors, Center for Addiction Medicine, Medical Sciences, Tirupathi, October 2015. NIMHANS, Bengaluru, 4 March 2016 (iv) Quitting tobacco use. One-Day Workshop on Preventing Tobacco Use among 183. Nandeesh BN, Anita Mahadevan, Amey Rajan Savardekar, the Youth and Young Adults – Working Together, We can end TC Yasha, Jitendra Saini, Vani Santosh. A clinicopathological the Tobacco Epidemic, NIMHANS, Bengaluru, 5 March 2016. study of the spectrum of skull base neoplasms. 17th Annual Conference of Skull Base Society of India, Skull Base Con 190. Neelesh Gupta, Malligurki R Rukmani, Talakad N Satyaprabha, 2015, Bengaluru, October 2015. Chandra SR, Autonomiuc dysfunction in patients with Alzheimer’s disease, TSS-NIMHANS, Knowledge Conclave 184. Narasimha VL, Nathan D, Ravishankar V, Kumar CN, Thirthalli 2016, NIMHANS, Bengaluru,12-13 February 2016. J, Sivakumar PT, Bharath S, Varghese M. Electroconvulsive therapy for elderly at NIMHANS: Retrospective chart review of 191. Nesin Mathew, Sabitha K Nair, Anupam Gupta, Laxmi T Rao. seven years. 1st Symposium on Non Invasive Brain Stimulation, Restoration of motor skills after Constraint Induced Movement NIMHANS, Bengaluru, 20 September 2015. Therapy (CIMT) in ischemic stroke rats. APPICON 2015, AIIMS, Jodhpur, 26-28 November 2015. 185. Nattala P, Aruna MK, Meena KS, Santosh Loganathan. Symposium on harnessing the potential of audio-visual aids. 192. Nirmala BP, Manjunath KS, Swarupa M, Shari Tess Mathew. 68th Annual National Conference of the Indian Psychiatric Qualitative study of needs and concerns of women care givers
294 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
of neurologically ill patients- Experience from super specialty Srinivas Bharath MM, John Vijaysagar, Sasi Chandra, Kavita tertiary care hospital in India. Two-day National Conference on Jangam. Not every trauma is accidental. Non accidental injury: Women’s Mental Health, Mysore, 9-10 October 2015. A high index of suspicion is required to identify it. 24th Annual Conference of Neurotrauma Society of India, Bengaluru, 21-23 193. Nirmala BP. Psychological distress and burden among caregivers August 2015. and neurological patients. 3rd Indian Social Work Congress 2015, Ladnun, Rajashtan, 24-26 October 2015. 202. Pendharkar H. (i) Complications in Neurointervention. 12th Monsoon Meet on Neurointervention Complications Goa, 194. Nirmala BP. Shari Tess Mathew, Swarupa Mohan. Quality 30 July-2 August 2015 (ii) Spinal vascular anatomy: Let’s start of life in rehabilitated persons following spinal cord injury; from the basics. 18th Annual Conference of ISNR, Indore, Hospital based cross sectional study. 34th Annual National Madhya Pradesh, 8-11 October 2015 (iii) Introduction to Conference of the Indian Society of Professional Social Work neuroimaging: Shades of gray and white. CME, Command (ISPSW) on Social Work and Sustainable Development, Hospital Airforce, Bengaluru, 18-19 December 2015 (iv) Spinal Bandarsindri, Rajasthan, 24-26 February 2016. vascular malformation. 18th Annual Conference of Indian Society of Vascular and Interventional Radiology, Bengaluru, 195. Nishanth Sadashiva, Dhaval Shukla, Dhananjaya Bhat, 18-21 February 2016. Sampath Somanna, Bhagavathula Indira Devi. Isolated sphenoid sinus lesions: A pictorial essay. Skull Base con 2015, 203. Periyavan S, Batra A. Role of therapeutic plasmapheresis in NIMHANS, Bengaluru, 10-11 October 2015. neuromyelitisoptica - 2 year Study. 4th Annual Conference of Indian Society of Transfusion Medicine, Apex Neuroscience 196. Nitin M, Chakrabarti D, Radhakrishnan M, Dheeraj M. Institute, Kolkata, 4-6 December 2015. Thiopentone requirement in TBI patients using BIS. Annual Conference of Neurotrauma Society of India, Bengaluru, 21-23 204. Phalguni Anand Alladi. (i) Brain aging: Insights from the August 2015. human substantia nigra pars compacta. AU-KBC Research Centre, MIT Campus of Anna University, Chennai, 24 April 197. Nitin M. (i) BIS and hemodynamic changes during surgical 2015 (ii) Admixing has a modulatory influence on substantia decompression in head injury patients. 17th Annual Conference nigra neurons: An experimental evidence for differential of ISNACC, NIMHANS, Bengaluru, 5-7 February 2016 prevalence of Parkinson’s disease. 33rd Annual Conference (ii) Hemodynamic changes with prone position in cervical of Indian Academy of Neurosciences, Panjab University, myelopathy patients undergoing surgery, 63rd Annual National Chandigarh, 1-3 November 2015 (iii) Aging and the synchrony Conference of Indian Society of Anaesthesiologists, Jaipur, 26- of neurodegenerative diseases. Nirma University, Ahmedabad, 29 December 2015. 15-16 January 2016.
198. Nitish Kamble, Ravi Yadav, Jitender Saini, Keshav kumar, 205. Poornima C, Deepthi, Sudhir PM. Therapy outcomes and Pramod Kumar Pal. Sleep characteristics and cognition in neuro pyschological profile of an adolescent with OCD and patients of Parkinson’s disease with REM sleep behavior auto immune disease. 42nd NACIACP, Imphal, Manipur, 24-27 disorder. MDSICON 2016, Chennai, 8-10 January 2016. February 2016.
199. Padmanabhan, B. Identification of novel inhibitors for 206. Poornima Mahindru, M Thomas Kishore, G Ragesh, Prabha the BRD2 bromodomain associated with cancer and Chandra, Geetha Desai, Harish T. Developmental outcomes in neurodegenerative diseases: A structure-based approach. 33rd infants of mothers with psychiatric problems during pregnancy. Annual Conference of Indian Academy of Neurosciences, National Conference on Motherhood and Mental Health, Chandigarh, 31 October-2 November 2015. NIMHANS, Bengaluru, 31 October 2015.
200. Pandian RD, Joseph AJA. Case management approaches 207. Prabhuraj AR. (i) Traumatic spinal arachnoid cyst - An for substance use in Indian context. 34th Annual National institutional experience. Annual Conference of Neurospinal Conference of the Indian Society of Professional Social Work Surgeons Association of India--SPINE 2015, Goa, 18- (ISPSW), Central University of Rajasthan, Rajasthan, 24-26 20 September 2015 (ii) Factors associated with hearing February 2016. preservation after Gamma Knife radiosurgery for vestibular schwannomas in patients with serviceable hearing. Skullbasecon 201. Pendharkar H, Nupur Pruthi, Rao KVLN, Manjul Tripathi, 2015, Bengaluru, 11-13 October 2015 (iii) Complications of
National Institute of Mental Health and Neuro Sciences 295 Annual Report 2015-2016
cranioplasty following decompressive craniotomy: Analysis of and Public Health Evidence South Asia (PHESA) Joint 112 cases. NSICON 2015, Hyderabad, 17-20 December 2015. Conference on Converging to Better Health with Statistical Methods, Manipal University, Manipal, 11-12 January 2016. 208. Pradeep K Mishra, Bindu M Kutty, Laxmi TR. Previous exposure to maternal separation stress impairs cued fear 213. Preeti Jacob. (i) Anxiety and mood disorders in children and extinction and differential fear conditioning in rats. APPICON adolescents. Annual Psychiatry CME 2015, Karnataka Institute 2015, AIIMS, Jodhpur, 26-28 November 2015. of Medical Sciences, Hubballi, 14 June 2015 (ii) Emotional and behavioural Problems in children with learning issues. Kalikeya 209. Pramod Kumar Pal. (i) Young onset Parkinson’s disease. Neurology Kale, a workshop for school teachers, Community Child and Update, Patna, 19 April 2015 (ii) Emergencies in PD. NeuroVision Adolescent Mental Health Service, NIMHANS, Bengaluru, 2015, Chennai, 18 July 2015 (iii) Stem cell research in movement 4 August 2015 (iii) Readiness skills. Arambhikeya Arambha, disorders, Indian Academy of Neurology sponsored: Expert a workshop for Anganwadi teachers, Community Child and Group Meeting on Stem Cell Treatment in Neurology, Gurgaon, Adolescent Mental Health Service, NIMHANS, Bengaluru, Haryana, 22-23 August 2015 (iv) Understanding and facilitation 11 August 2015 (iv) Emotional and Behavioural Problems in of neural plasticity for enhancing post stroke recovery. Seminar Children with Learning Issues. Workshop for principals and organized by CEFIPRA as a collaborative task force between the teachers of CBSE schools –Sahodaya, Sahodaya forum for CBSE French and Indian Scientists, AIIMS, New Delhi, 29-31 October Schools, 14 September 2015 (v) Disruptive behaviour disorders. 2015 (v) (a) Movement disorders-Video session (b) Clinical Madhya Pradesh Psychiatric Society Annual Conference Approach to Ataxias (c) Differential diagnosis of Parkinson (MPPSYCON), Bhopal, Madhya Pradesh, 4 October 2015 (vi) syndrome. Neuro Update 2015, Bengaluru, Vydehi Institute of Nature of child sexual abuse: Impact on survivors and implications Medical Sciences and Research Centre, Bengaluru, 6 November on the trial. Capacity Building for Judges of Special Courts, 2015 (vi) Management of early and advanced Parkinson disease. UNICEF and Centre for Child and Law (CCL), National Law Pre-Conference CME, 29th Annual Conference of Association of School India University (NLSIU), Bihar, 31 May 2015. Neuroscientists of Eastern India (ANEICON 2015), Siliguri, West Bengal, 20 November 2015 (vii) Clinical and imaging approach to 214. Priya Baby. Prediction of prognosis in traumatic brain injury ataxia, 1st Annual Conference of the Movement Disorders Society by clinical Nurses. 24th Annual National Neurotrauma of India (MDSICON 2016), Chennai, 8-10 January 2016 (viii) Conference, Dept. of Nursing NIMHANS, Bengaluru, 21-23 Non-invasive brain stimulation in understanding pathophysiology August 2015. and modulating neuroplasticity in cognitive dysfunction. TS. Srinivasan Knowledge Conclave 2016: Workshop on Cognition 215. Priya Puri, Prasanta Kumar Roy. (i) Hypnotherapy as a and Dementia, NIMHANS, Bengaluru, 12-13 February 2016 (ix) therapeutic tool for homosexual anxiety: A single case study. 10th Movement disorders, SHINE 2016, Chennai, 27 February 2016. National Conference on Clinical and Experimental Hypnosis, Dharmaram Vidya Kshetram, Bengaluru, 20-22 November 210. Prasad C. (i) MRI visualization of white matter system, DTI 2015 (ii) The interplay between parenting and borderline Tractography, surgical implications and anatomy correlation. personality disorder - A comparative study. 42nd NACIACP, Neurofest 2015, RUHS College of Medical Sciences Jaipur, RIMS, Imphal, Manipur, 25-27 February 2016. Rajasthan 29-31 October 2015 (ii) Neuroradiology in Dementia. Indian Psychiatric Society, Bihar State Branch, 6th 216. Priyanka M, Manjula M. Experiences in romantic relationships Annual Conference, Bihar, 6 November 2015 (iii) Alexander among young adults: A qualitative study. 42nd NACIACP, disease with basal ganglionic and subcortical calcification. 69th RIMS, Imphal, Manipur, 25-27 February 2016. IRIA Conference 2016, Bhubaneswar, 21- 24 January 2016. 217. Radhakrishnan G. (i) Teaching learning strategies in transformative 211. Prashant D, Manjula R, Padmanabhan B. Screening of potential curriculum. National Symposium on Transformative Curriculum molecules to inhibit the Keap1-Nrf2 interaction. Annual in Nursing, Bishop Benzigar College of Nursing, Kollam, 8 Meeting of Indian Biophysical Society: Molecules in living cells: August 2015 (ii) Nursing research related to spinal cord injuries. Mechanistic basis of function, Bangalore, 8-10 February 2016. 24thAnnual National Conference of Neuro Trauma Conference, NIMHANS, Bengaluru, 21-23 August 2015 (iii) Clinical nursing 212. Prathyusha PV, Subbakrishna DK, Thennarasu K, research in maternal and women related psychiatric problems and Venkatasubramanian G. Multidimensional scaling for interventions - PMS, Postpartum Psychosis/ Depression. 15th functional connectivity analysis in neuroimaging. The National Conference of Indian Society of Psychiatric Nurses International Biometric Society - Indian Region (IBS - IR) (ISPN), Karad, Maharashtra, 13 February 2016 (iv) Nurses’
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role in psychiatric rehabilitation services. National Workshop 224. Rahina A, Pradeep Y, Bindu PS. Auditory neuropathy spectrum on Nurses Role in Psychiatric Rehabilitation Services, Dept. disorder in hypomyelinating leukodystrophy- A case study. 8th of Nursing and Dept. of Psychiatric Rehabilitation Services, Annual Conference of Indian Speech and Hearing Association NIMHANS, Bengaluru, 5 March 2016. (Kerala), Waynad, Kerala, 12-13 September 2015.
218. Radhakrishnan M. (i) Ultrasound in neuro ICU. 2nd Annual 225. Rahina A, Pradeep Y. Development of binaural fusion tests Conference of Society of Neurosonology. Bengaluru, 2-3 August in Malayalam. 8th Annual Conference of Indian Speech 2015 (ii) Head injury management. Global Neurosciences and Hearing Association (Kerala), Waynad, Kerala, 12-13 Master Class, Chennai, Tamil Nadu, 12-13 September 2015 September 2015. (iii) Anticoagulants and antiplatelets in neurosurgical and neuroradiological procedures. All India Institutes of Medical 226. Rajalakshmi P, Anita Mahadevan, Arivazhagan A, Sanjib Sinha, Sciences (AIIMS) Neuroanaesthesia Update, New Delhi. 26-27 Rose Dawn Bharath, Saini J, Bhaskar Rao M, Satishchandra P. September 2015 (iv) Weaning in cervical spine injury patients. Neuropathological spectrum of drug resistant epilepsy over a 2nd Annual Medantaneurocritical Conference, Gurgaon, 11-12 decade – An audit from a tertiary care centre. APCON 2015, December 2015. Kochi, 3-6 December 2015.
219. Ragasudha Botta, Sheshagiri Donirpathi, Arun Sasidharan, 227. Rajalakshmi P, Anita Mahadevan, Arivazhagan A, Sanjib Sinha, Ravi Yadav, Pramod Kumar Pal, Sanjeev Jain, Bindu M Kutty, Rose Dawn Bharath, J Saini, Bhaskar Rao M, Satishchandra Assessment of sleep spindle density among genetically positive P. Neuropathological spectrum of drug resistant epilepsy over spinocerebellar ataxias type 1, 2 and 3 patients: A comparative a decade – an audit from a tertiary care centre. NPSICON, study. MDSICON 2016, Chennai, 8-10 January 2016. 19-20 December 2015, Hyderabad. (Best Poster Award: Miscellaneous Category) 220. Ragasudha Botta. (i) Assessment of sleep spindle density among genetically positive spinocerebellar ataxias type 1, 2 and 228. Rajalakshmi R. (i) Attitude of Nursing students towards 3 patients: A comparative study. 23rd Annual Conference of the survivor of traumatic brain injury with severe disability (ii) Indian Academy of Neurology, Agra, 1-4 October 2015 (ii) Attitude of Nursing professionals towards oral care in traumatic Apraxia of eyelid closure in a case of Japanese encephalitis: A brain injury patients, 24th Annual National Neuro Trauma case report. 64th Annual Conference of Neurological Society of Conference, Dept. of Nursing, NIMHANS, Bengaluru, 21-23 India (NSICON 2015), HICC, Hyderabad, 17-20 December August 2015. 2015 (iii) Assessment of sleep spindle density among genetically positive Spinocerebellar ataxias type 1, 2 and 3 patients : A 229. Rajesh Kumar. Neuropsychology assessment. 5th National comparative study. 1st Conference of the Movement Disorders Workshop in CEN Neuropsychological Assessment and Society of India (MDSICON), Chennai, January 2016. Rehabilitation: Roots to Fruits (NANR-RF 2015), NIMHANS, Bengaluru, 16-18 July 2015. 221. Ragesh G, Anu KN, Prasad Reddy, Geetha Desai, Ameer Hamza, Harish T, Prabha Chandra. An enquiry on psychosocial 230. Rajesh Kumar, Keshav Kumar J, Vivek Benegal, Roopesh issues of women with perinatal psychiatric disorders in India. BN. Neuropsychological rehabilitation in alcoholism: Case National Conference on Motherhood and Mental Health, study. 5th National Workshop in CEN Neuropsychological NIMHANS, Bengaluru, 31 October 2015. Assessment and Rehabilitation: Roots to Fruits (NANR-RF 2015), NIMHANS, Bengaluru, 16-18 July 2015. 222. Ragesh G, Veenasree, Sajitha K, Ameer Hamza, Harish T, Geetha Desai, Prabha Chandra. Group intervention for 231. Rajeshwari Parida, Sanjay Das, Manorama Patri, Raju TR, spouses of women with perinatal psychiatric disorders. National Sathyaprabha TN. Expression of IL-2 and TNF-α in the Conference on Motherhood and Mental Health, NIMHANS, hippocampus of male Wistar rat in adverse physiological Bengaluru, 31 October 2015. conditions- A pilot study. APPICON 2015, AIIMS, Jodhpur, Rajasthan, 26-28 November 2015. 223. Raghavendra K, Chaitanya G, Sinha S, Bagepelli BS, Bharath RD, Saini J, Panda R, Satishchandra P. Influence of Cortical 232. Rajeswaran J. (i) Neuropsychology: Introduction and interpretation. Morphometry and white matter integrity in patients with Neuropsychological CEN 2015 and 5th National Workshop ‘hot-water epilepsy’. ECON 2016, Vishakhapatnam, 12-14 on Neuropsychological Assessment and Neuropsychological February 2016. Rehabilitation: Roots to Fruits, NIMHANS, Bengaluru, 16-
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18 July 2015 (ii) Neuropsychological rehabilitation: EEG from best practices of disability sector: Implications for Neurofeedback therapy in TBI. 24th Neurotrauma Conference, psychiatric rehabilitation. Psychiatric Rehabilitation Services, Neurotrauma Society of India, Bangalore, 21-23 August 2015 Dept. of Psychiatry, NIMHANS, Bengaluru, 19 September (iii) Post traumatic amnesia. Conference on Traumatic Brain 2015 (iv) Psychosocial perspectives of patients towards Injury - A Multidisciplinary Approach, Dr. SR Chandrasekhar technological advances. Dept. of Nursing, NIMHANS, 26 Institute of Speech and Hearing, Bengaluru, 10-11 September October 2015 (v) Panel discussion on IPR and communication, 2015 (iv) EEG Neurofeeback Training in TBI- Challenges and NIMHANS, Bengaluru, 23 November 2015 (vi) Panel difficulties. AIIMS Neurotrauma Conference (ANTC), All discussion and Group discussion on integrating mental health India Institute of Medical Sciences, New Delhi, 28-31 October care and chronic non-communicable disorders. Gulbenkian 2015 (v) Cognitive Neurosciences. The Ishaan Vikas - Udhaan Gloval Mental Health Platform (supported by World Health Programme, NIAS, Bengaluru, 15 December 2015 (vi) The organization), NIMHANS, Bengaluru, 13-15 November 2015 role of cognitive style in creativity and higher education. AAPI (vii) Caveats in psychiatric rehabilitation. National Conference Bangalore Chapter, Widia Poornaprajna School, Bengaluru, 30 on Approach the Future of Health-Social Integration and January 2016 (vii) Neuropsychology: An overview. Orientation Rehabilitation Solutions. College of Nursing, Sri Ramakrishna Program on Clinical Psychology: Promoting Mental Health Institute of Paramedical Sciences, Coimbatore, 21 November for Postgraduate Students of Psychology, Dept. of Clinical 2015 (viii) Introduction to research Process Review of research Psychology, NIMHANS, Bengaluru, 5-6 February 2016 Methodology. Karnataka College of Nursing, Bangalore, 21 (viii) Neurofeedback Therapy. Workshop on Neurofeedback January 2016 (ix) Synergy model for patient care. Transforming Therapy, Sri Sathya Sai Institute of Higher Medical Education, Care at Bedside (TCAB) Ameliorates patient care and improves Bengaluru, 27 February 2016 (ix) Cognition and dementia. vitality of health care team, College of Nursing, NIMHANS, TSS NIMHANS Knowledge Conclave 2016, NIMHANS, Bengaluru,11-12 January 2016. Bengaluru, 12-13 February 2016 (x) Brain-computer interface (BCI). Rehabilitation Council of India sponsored CRE Program 236. Ramana GV. Introduction to Ayurvedic principles of on application of Neuro-Biofeedback Therapy among patients psychiatric disorders and clinical evaluation of Comprehensive with Neuro-Psychiatric Conditions, Dept. of Psychology and management of Manodwega (GAD). NIMHANS Faculty Mental Health, School of Humanities and Social Sciences, Meeting, NIMHANS, Bengaluru, 17 February 2016. Gautam Buddha University, Uttar Pradesh, 3-5 March 2016. 237. Ramesh VJ. (i) TCD in brain death. 2nd Annual Conference 233. Rajini M Naduthota, Lija George, Ketan Ramakanth of Neurosonology, Bangalore, 2-3 May 2015 (ii) Paroxysmal Jhunjhunwala, Jitender Saini, Rose Dawn Bharath, Ravi sympathetic hyperactivity in sTBIpts – Mechanisms and Yadav, Pramod Kumar Pal, Diffusion Tensor Imaging study in Treatment. 24th Annual National Conference of Neurotrauma patients with Parkinson’s disease: Comparison between tremor Society of India, Bengaluru, 21-23 August 2015 (iii) Extubation of dominant and akinetic rigid subtypes. 1st Annual Conference of a neurosurgical airway. Annual Conference of All India Difficult the Movement Disorders Society of India (MDSICON 2016), Airway Association, National Airway Conference 2015 (NAC Chennai, 8-10 January 2016. 2015), Sheri Kashmir Institute of Medical Sciences, Srinagar, 18- 20 September 2015 (iv) Intraoperative rupture during aneurysmal 234. Raju TR. (i) Chitotriosidase - A novel molecule in surgery. AIIMS Neuroanaesthesia Update 2015, JLN Auditorium, neuroinflammation. 61st Annual Conference of Association of AIIMS, New Delhi, 26-27 September 2015. Physiologists and Pharmacologists of India (APPICON 2015), AIIMS, Jodhpur, 26-28 November 2015 (ii) A translational 238. Rao NP. (i) Neurobiology of schizophrenia. Andhra Pradesh neurophysiology - Need of the hour for devastating neurological Psychiatry Conference, Kurnool, 12 July 2015 (ii) State of disorders. 5th FIPS PHYSICON-2015 Meeting, Kolkata, 18- the art: BPAD. Educational workshop on Neuroimaging - 20 December 2015. What the Neuro-Psychiatrist Should Know, Srinagar, 25 July 2015 (iii) Antipsychotic adherence and treatment outcome: 235. Ramachandra. (i) Innovative teaching strategies in nursing Revisiting long acting antipsychotics. Mangalore Psychiatric education. Workshop on Problem Based Learning, Vydehi Society, Mangalore, 23 September 2015 (iv) Neurobiology Institute of Nursing Sciences and Research Center, Bangalore, of yoga in mental illness. 48th Annual Conference of Indian 10 April 2015 (ii) Attitude practices and perceptions among Psychiatric Society - South Zone, Nellore, 18 October 2015 nursing professionals towards oral care in traumatic brain injury (v) Neuroimaging in psychiatry: Techniques and applications. patients. 24th Annual National Neurotrauma Conference 2015, Continuing Medical Education, Indian Psychiatric Society - NIMHANS, Bengaluru, 21-23 August 2015 (iii) Learning Karnataka Chapter, 19 December 2015 (vi) How to publish
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a paper. Postgraduate CME - Indian Psychiatric Society – BN. Barriers to access psychiatric treatment among persons Karnataka Chapter, 10 January 2016 (vii) From genome to with schizophrenia in a rural south Indian taluk. DECADE phenome: Linking genes with brain using neuroimaging. Conference, Thirthahalli, 12 December 2015. Annual National Conference of Indian Psychiatric Society, Bhopal, 21-24 January 2016. 245. Reddy PR, Rajeswaran J, Bhagavatula I, Kandavel T. Neurofeedback training as an intervention for quality-of life 239. Ravi GS, Thennarasu K, Nayak CS, Sinha S. Multilevel and post-concussion symptoms in silent epidemic: A new modeling approach for phase synchronization analysis of EEG hope. 24th Annual NTSI Neurotrauma 2015 Conference, data of patients with epilepsy. IBS-IR Conference, Bangalore, NIMHANS, Bengaluru, 21-23 August 2015. January 2016. 246. Reddy PR. (i) Visuospatial functions and parietal lobe 240. Ravi V. (i) Emerging viral encephalitis in India. Mid Term assessment; Integrated neuropsychological rehabilitation: Case Meeting of Neurological Society of India – Kerala Chapter, study. Neuropsychological Assessment and Rehabilitation: Department of Neurosciences, Pushpagiri Institute of Medical Roots to Fruits, NIMHANS Bengaluru, 16-18 July 2015 Sciences, Thiruvalla, Contour Backwaters, Changanacherry, (ii) Forensic Psychology: current status. Clinical Psychology: Kerala, 8 November 2015 (ii) (a) Microarrays and future Promoting Mental Health, NIMHANS, Bengaluru, 5-6 diagnostic assays. (b) Recent advances in arboviral vaccines. 20th February 2016. Annual Conference of IAMM-KC KC-MICROCON 2016, Bangalore Medical College and Research Institute, Bengaluru, 247. Reddy SK, Thirthalli J, Kumar CN, Rawat VS, Manjunatha 19-20 February 2016. N, Reddy NK, Renukadevi NR, Suresh KK, Jagannathan A, Gangadhar BN. Factors influencing access to Psychiatric 241. Ravi GS, Thennarasu K, Chetan S Nayak, Sanjib Sinha. Treatment among persons with Schizophrenia. A Rural (i) Censored quantile regression based gene signature for Community of South India, Deliberations on Care Delivery prognosis of Glioblastoma. 33rd Annual Conference of Indian (DECADE) for Mental Illness in Rural Communities Society for Medical Statistics, KLE University, Belagavi, 14- Conference, Thirthahalli, 12 December 2015. (Best Poster 16 October 2015 (ii) Multilevel modeling approach for phase Award) synchronization analysis of EEG data of patients with epilepsy, The International Biometric Society - Indian Region (IBS - 248. Rohini M Surve, Sonia Bansal, Madhusudan Reddy, Mariamma IR) and Public Health Evidence South Asia (PHESA) Joint Philip. Use of dexmedetomidine along with local infiltration Conference on Converging to Better Health with Statistical versus general anaesthesia for burr hole and evacuation of Methods, Manipal University, Manipal, 11-12 January 2016. chronic subdural hematoma (CSDH). 24th Annual Conference of Neurotrauma Society of India, Bengaluru, 21-23 August 242. Ravi GS, Thennarasu K, Vani Santosh, Arivazhagan A. 2015. (i) Censored quantile regression based gene signature for prognosis of glioblastoma. 33rd Annual conference of Indian 249. Roopesh BN, Anjali S, Meghana V, Vijaysagar J. Decision Society for Medical Statistics, KLE University, Belagavi, 14- making in children with conduct disorder. 13th Biennial 16 October 2015 (ii) Multilevel modeling approach for phase Conference of the Indian Association for Child and Adolescent synchronization analysis of EEG data of patients with epilepsy. Mental Health, Pune, Maharashtra, 19- 21 November 2015. The International Biometric Society - Indian Region (IBS - IR) and Public Health Evidence South Asia (PHESA) Joint 250. Roopesh BN, Mukundan CR, Janardhan Reddy YC. Reduced conference on Converging to Better Health with Statistical misallocation of attentional resources post treatment in Methods, Manipal University, Manipal, 11-12 January 2016. OCD: An event related potential study. 42nd National Annual Conference of Indian Association of Clinical Psychologists, 243. Ravikumar R. (i) Transfusion associated bacterial infection Imphal, Manipur, 24-27 February 2016. with a word on pathogen inactivation. Indira Gandhi Institute of Child Health, Bangalore, 8 October 2015 (ii) Issues and 251. Roopesh BN. Child and adolescent mental health. Clinical challenges in laboratory diagnosis of CNS infections. JIPMER Psychology: Promoting Mental Health. An Orientation IAMM Conference, 28 November 2015. Programme for Postgraduate Students of Psychology, NIMHANS, Bengaluru, 5- 6 February 2016. 244. Reddy KS, Kumar CN, Thirthalli J, Rawat VS, Manjunatha N, Reddy NK, Renukadevi NR, Suresha KK, Gangadhar 252. Rose Dawn Bharath. (i) (a) Functional brain imaging – Basics
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(b) Resting state functional brain imaging- Introduction (c) 255. Saini J. (i) Diagnostic imaging of subarachnoid hemorrhage. Functional brain imaging – Applications. Vellore, 20-22 August 18th Annual Conference of ISNR, Indore, 8-11 October 2015 2015 (ii) Epilepsy and resting state. NESSAN, Hyderabad, 27 (ii) Structural imaging in movement disorders. 1st Annual September 2015 (iii) Neuroimaging. NIMHANS-University of Conference of Movement Disorder Society of India, Chennai Liverpool Meeting, NIMHANS, Bengaluru, 30 September 2015 8-10 January 2016. (iv) Recovery from Neurotrauma. 5th Asian Australasian Society of Neurological Surgeons Neurotrauma Committee and 2nd WFNS- 256. Sampath S. Neuro endoscopy. Neurosurgery updates III, Military Neurosurgeon’s Meeting, Jaipur, 9-11 October 2015. Rahaman Hospitals Pvt. Ltd, Guwahati, 11-13 June 2015 (ii) Extended endoscopic endonasal surgery. CME Workshop, 253. Sadana D. (i) Effect of age and education on neuropsychological Eluru, Andhra Pradesh, 24-26 July 2015 (iii) Extended profile of patients with traumatic brain injury. 24th endoscopic endonasal transcival clipping of basilar artery Neurotrauma Conference, Neurotauma Society of India, aneurysm. Neurovascon 2015, Ludhiana, 19-20 September NIMHANS, Bangalore, 21-23 August 2015 (ii) Severe head 2015 and Skullbasecon 2015, Bangalore 10-11 October injury: A daunting challenge for neurorehabilitation. AIIMS 2015 (iv) Skull base tumors aneurysms. WFNS Skull Base Neurotrauma Conference, (ANTC) 2015, AIIMS, New Delhi, Neuroendoscopy Workshop, AIIMS, New Delhi, 25- 26 28-31 October 2015. November 2015 (v) Extended transnasal endoscopic approaches. CME, Care Hospital, Hyderabad, 12 March 2016. 254. Sailaxmi Gandhi. (i) Role of nurses in psychiatric rehabilitation services. Symposium on Nuts and Bolts of Starting and Running 257. Sandatta Sen, Meera Purushotaman, Lokeshnarayanan, Nalini Psychiatric Rehabilitation Services. Psychiatric Rehabilitation A, Chandra SR, Srikala Bharath, Suresh Kumar, Sonam et al,. Services, NIMHANS, Bengaluru, 4 April 2015 (ii) Role of Expansions of nucleotide repeat length in neurodegenerative schools in management of emotional disturbances. Workshop disease, IISc, Bengaluru, 17-19 November 2015. on Role of School Teachers in classroom management of Childhood Emotional, Developmental and Behavioral Problems, 258. Sandhya M, Pankaj B, Menon S, Srinivasa R, Hegde AS. Neural Department of Nursing, NIMHANS, Bengaluru, 13 April correlates of autobiographical memory and self in patients of 2015 (iii) Nurses role in management of a patient with spinal stroke and head injury. TS Srinivasan NIMHANS Knowledge cord injury. Satellite Conference of Neurotrauma Nursing Conclave 2016, NIMHANS, Bengaluru, 12-13 February 2016. 2015 and 24th Annual Conference of NTSI 2015, NIMHANS, Bengaluru, 21-23 August 2015 (iv) Demonstration of mental 259. Sanjeev Jain. (i) Genetics, Genomics and proteomics – What status examination. Induction Program for newly joined Staff is it about? Biennial Conference of Indian Association of Child Nurses, NIMHANS, Bengaluru, 8 October 2015 (v) Disaster and Adolescent Mental Health, Pune, 19-21 November 2015 (ii) preparedness – national and local level. Workshop on Nurses Role Recent advances in molecular biology of Huntington’s disease. in Disaster Management, Department of Nursing, NIMHANS, 1st National Conference of the Movement Disorders Society of Bengaluru, 21 November 2015 (vi) IPR and communication. India (MDSICON- 2016), Chennai, 8-10 January 2016. Panel discussion, NIMHANS, Bengaluru, 23 November 2015 (vii) Research methodology. LGBRIMH, Tezpur, Assam, 18-19 260. Santhosh NS, Chaitanya G, Ravi GS, Sanjib S, Thennarasu K, January 2016 (viii) Training of professionals to train persons with Arivazhagan, Anitha M, Bharath RD, Jitender Saini, Jamuna R, mental illness in Activities of Daily living Skills. Workshop on Keshav M, Rao MB, Satishchandra P. Predictors of secondarily Quality of Life in Chronic Mental Illness: Exploring new frontiers generalized seizures in EMU in patients with temporal lobe workshop, NIMHANS, Bengaluru, 30 January 2016 (ix) Training epilepsy. 16th Annual Joint Conference of Indian Epilepsy of professionals to train persons with mental illness in Activities Association (IEA) and Indian Epilepsy Society, Chennai, 6-8 of Daily living Skills. Workshop on Quality of Life in Chronic February 2015. Mental Illness: Exploring new frontiers workshop, NIMHANS, Bengaluru, 30 January 2016 (x) Demonstration of Mental Status 261. Sathishchandra P. (i) Information technology and healthcare Examination. Induction Program for newly joined staff nurses, needs of an emerging India: Framing a Research Agenda NIMHANS, Bengaluru, 4 February 2016 (xi) Clinical research for e-Health Launch of E-Health Research Centre, IIIT, in patients with chronic mental illness. 15th Annual National Bangalore, 15 September 2015 (ii) Epilepsy-semiology and ISPN Conference, Krishna Institute of Nursing Sciences, Karad, diagnosis pearls in clinical psychology. 2nd Annual Conference, Maharashtra, 13 February 2016 (xii) Domestic skills and its Apollo Hospitals, Nellore, 22 November 2015 (iii) Developing therapeutic values. Workshop on Role of Nurses in Psychiatric neurosciences institute in India: NIMHANS as a model. BMC Rehabilitation, NIMHANS, Bengaluru, 5 March 2016. Diamond Jubilee Celebrations, CME Programme, Scientific
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Bouquet, Bengaluru, 1 December 2015 (iv) Mobile addiction: for Youth, NIMHANS Centre for Well-Being, Bengaluru, 4 Can this be prevented. INSPIRE-2015 Science Nurture Camp, July 2015. Sree Siddaganga Education Society, Sree Siddaganga College of Arts, Science and Commerce for Women, Tumkur, 26 267. Seena Thomas, Thennarasu K, Philip M. Comparison of December 2015 (v) CNS Infections in immunocompromised imputation techniques in missing data analysis: A simulation patients Neuro Update. Choithram Neurosciences Society, study. The International Biometric Society - Indian Region (IBS Indore, 9 January 2016 (vi) Opportunistic infections associated - IR) and Public Health Evidence South Asia (PHESA) Joint with HIV/ AIDS: Indian perspective. 6th Annual Conference Conference on Converging to Better Health with Statistical of the Karnataka Neurosciences Academy (KNACON – 2016), Methods, Manipal University, Manipal 11-12 January 2016. MR Medical College, Gulbarga, 29 January 2016 (vii) Genetics of epilepsy: Indian perspective. Pre Congress Workshop, 268. Sekar K, Kavitha P, Preeti J, Kavita J. Psychosocial care for children ECON 2016, Vishakhapatnam, 12 February 2016 (viii) HIV in conflict with law (oral presentation), 34th Annual National and Cognition: Indian perspective, 2nd TSS-NIMHANS Conference of the Indian Society of Professional Social Work Knowledge Conclave, NIMHANS, Bengaluru, 13 February (ISPSW), Central University of Rajasthan, 24-26 February 2016. 2016 (ix) Tuberculous meningitis with stroke like presentation. CME programme in connection with World TB Day, Rajiv 269. Selva Ganapathy, Chandra SR, Ravi GS, Srikal Bharath. Gandhi Institute for Chest Diseases, Bengaluru, 26 March Comparison of balance and gait abnormalities in frontotemporal 2016 (x) Controversies in epilepsy. Patna Neurological Society dementia and Alzheimer diseases with control subjects: A pilot Meeting, Patna, 19 March 2016 (xi) Infections and dementia. study. 2nd TS Srinivasan-NIMHANS knowledge Conclave- 36th TS Srinivasan Oration 2016, Symposium on Forgetful Cogntion and Dementia, NIMHANS, Bengaluru, 12-13 Brain, Chennai, 14 February 2016. February 2016.
262. Sathyanarayana Rao TS, Darshan MS, Andrade C. A 24-week 270. Senthil Amudhan R. (i) Promoting wellness of health through prospective study to assess cost-efficacy of and compliance with health education. National Seminar on Education for Building antidepressants in the rural population. 68th Annual National People’s Capacity towards Sustainable Development, Dept. of Conference of the Indian Psychiatric Society, Bhopal, 21-24 Social Work, St. Aloysius College (Autonomous), Mangalore, January 2016. (Marfatia Award) 23 September 2015 (ii) Programmes and policies for the differently-abled. Seminar on Entrepreneurship in Speech and 263. Sathyaprabha TN (i) Autonomic function in health and Hearing, Indian Speech and Hearing Association, Manipal, 22 diseases. CME on Current trends in Neuroanatomy and November 2015 (iii) Jury for the scientific presentations. 10th Neurophysiology, BGS Global Medical College, Bengaluru, Indian Academy of Cerebral Palsy Conference 2015, Cuttack, 27 May 2015 (ii) Autonomic dysreflexia in spinal cord injuries. Odisha, 19 December 2015 (iv) Presidential symposium on Neurotrauma 2015, NIMHANS, Bengaluru, 21-23 August Early Diagnosis Guidelines for Childhood Developmental 2015 (iii) Autonomic dysfunction in neurological disorders. Disability- Interpreting the evidence for Action. 10th Indian APPICON 2015, Jodhpur, 26 November 2015. Academy of Cerebral Palsy Conference 2015, Cuttack, Odisha, 19 December 2015 (v) Building research designs on 264. Satyaprabha TN, Meghana A, Sinha S, Satishchandra P. data systems in industries - 1 (cross sectional, case control). Effect of carbamazepine monotherapy on electrocardiograpm Professional Development Course, OCCUCON-2016, in patients with complex partial seizures. ECON 2016, NIMHANS, Bengaluru, 17 February 2016. Vishakhapatnam, 12-14 Febuary 2016. 271. Shamili Asokan, Ravi GS, Meera SS, Shivashankar N. 265. Seema N, Manjula M, Shyam Sunder A. Integrating INCLEN Diagnostic tool for autism spectrum disorder: A mindfulness with CBT in a client with Bipolar Disorder. 42nd new tool in the clinician’s armory. 48th Annual convention of National Annual Conference of IACP, Imphal, Manipur, 25-27 Indian Speech and Hearing Association, Kokilaben Hospital, February 2016. Mumbai, 5-7 February 2016.
266. Seema PN, Manjula M. (i) Emotion regulation: Counteractive 272. Shanivaram Reddy K, Thirthalli J, Kumar CN, Reddy NK, to proactive. Workshop on Emotion Regulation for Healthy Manjunatha N , Renukadevi NR, Suresh KK, Gangadhar Living. NIMHANS Centre for Well-Being, Bengaluru, 25 BN. Factors influencing on access for psychiatric treatment in April 2015 and 27 October 2015 (ii) Relationships with parents. persons with schizophrenia in rural community of South India. Workshop on Managing Healthy Interpersonal Relationships Conference on Deliberations on Care Delivery (DECADE)
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for Mental Illness in Rural Communities, Commemorating a Training program on Managing People, Targets and Self for decade of service based research in Thirthahalli, Thirthahalli, Asst. Commissioners to Chief Commissioners, Direct Taxes 12 December 2015. Regional Training Institute, Bengaluru, 18 November 2015 (iv) (a) Cognitive behavioural perspective of sexual health: From 273. Shankar SK. (i) Alcoholism- Adult brain. MVJ College, conditioning to deconditioning (b) Approaches to sex therapy Bengaluru, July 2015 (ii) A talk on Brain Donation. Let us join – Sensate focus. Workshop on Cognitive Behaviour Therapy hands for better care. World Alzheimer’s Day Celebrations, in Sexual Dysfunctions, Behavioural Medicine Unit, Dept. Annasawmy Mudaliar General Hospital (AMGH), in of Clinical Psychology, NIMHANS, Bengaluru, 7-8 January association with ARDSI, Bengaluru Chapter, Bengaluru, 2016 (v) Meditation in stress management. Gitanjali Medical September 2015 (iii) (a) Brain banking in India and brief College and Hospital, Udaipur, Rajasthan, 12 February 2016 note on CJD (b) Pathobiology of vasospasm. Neuropathology (vi) Relevance application of mindfulness integrated cognitive Society of India (NPSICON 2015), Hyderabad, December behavioural interventions in clinical and non-clinical settings. 2015. 42nd National Annual Conference of Indian Association of Clinical Psychologists, RIMS, Imphal, Manipur, 25 -27 274. Shankaranarayana Rao BS, (i) Stress and brain disorders: February 2016. Developing novel treatment strategies. Workshop on Emerging Trends in Medicine and Healthcare, Karnataka 277. Shekhar Seshadri. (i) Transgender issues-The predicament Science and Technology Academy and NMKRV College of of metaminorities, 38th Annual Science Festival, Bangalore Women, Bengaluru, 19 June 2015 (ii) (a) Writing a research Science Forum, Bengaluru, 27 July 2015 (ii) Keynote address, paper and publishing it in an indexed journal (b) The ever Counselling in India - A Practitioner’s Conference, Parivarthan changing brain and new challenges in treating brain disorders. Counselling, Training and Research Centre, Ecumenical 2nd National Conference of Association of Physiologists Christian Centre, Bengaluru, 28-29 August 2015 (iii) Child of India, (ASSOPICON 2015), Shri Ram Murti Smarak abuse in 13th Annual Conference of IAPP, Faizabad, UP, 4-5 Institute of Medical Sciences, Bareilly, Uttar Pradesh, 26- September 2015 (iv) Management of IDD, Association of 29 October 2015 (iii) The ethics of scientific research and Psychiatrists, Jabalpur, 14 November 2015 (v) Psychosocial and publication. National Conference on Ethical issues in scientific sexual abuse. 13th Biennial Conference of Indian Association of writing, Maharani’s Science College for Women, Bengaluru, Child Adolescent Mental Health, (IACAM 2015), Pune, 20 3-4 September 2015. November 2015 (vi) Emerging challenges for today’s school principals. Deccan Herald in Education (DHiE) Seminar, 275. Shanti Arya. Requirement of ankle foot orthosis in patient Bengaluru, 30 January 2016. with genetically established duchenne muscular dystrophy – A four-year study from a multi-disciplinary neuro-muscular 278. Shetty S, Vradna MN, Shari M, Naveen KC. A case of psychosis clinic. 22nd National Conference of Orthotic and Prosthetics NOS with poor social support and community reintegration. Association of India, New Delhi, 12-14 February 2016. Conference on Deliberations of Care Delivery for Mental Illness in Rural Communities, NIMHANS and Indian Society 276. Sharma MP. (i) (a) Cognitive behaviour therapy: An of Psychiatry – Karnataka Chapter, Thirthahalli, Shivamoga, 12 introduction (b) Beliefs, Assumptions and thoughts (c) December 2015. Assessment in CBT: An overview of methods and strategies (d) Cognitive behavioural therapeutic procedures: Verbal and 279. Shilpa Rao, Anita Mahadevan, Maya D Bhat, Chandrajit behavioural strategies (e) Cognitive behavioural management Prasad, Madhusudana SN, Satishchandra P, Shankar SK. of depression (f ) Problems encountered in CBT (g) Moving Neuropathological correlation of neuroimaging features in human towards metacognitions: Mindfulness-integrated cognitive rabies encephalitis. NPSICON, Hyderabad, 19-20 December behaviour therapy in the management of OCD. Workshop on 2015. (Best Poster Award; Infections Category- 2nd Prize). CBT: Principles and Applications, Department of Psychiatry, Gitanjali Medical College and Hospital, Udaipur, Rajasthan, 280. Shiva L, Miriyala S, Sivakumar PT, Thirthalli J, Kumar CN. Safe 18-19 April 2015 (ii) (a) Cognitive behaviour therapy: An administration of electroconvulsive therapy in a depressed patient introduction (b) Assessment in CBT: Methods and strategies (c) who had underwent craniotomy. 1st Symposium on Non Invasive Cognitive behavioural management of depression. Workshop Brain Stimulation, NIMHANS, Bengaluru, 20 September 2015. on CBT: Principles and Applications, Behavioural Medicine Unit, Dept. of Clinical Psychology, NIMHANS, Bengaluru, 281. Shripad A Patil. (i) Neurocysticercosis: A problem in the 9-10 July 2015 (iii) Mindfulness in stress management. society. 42nd Indian Immunology Society Meeting, Patna,
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9-11 October 2015 (ii) Cysticercosis: An important but Bhat, Narasinga Rao KVL, Jeru Manoj M. Two common neglected disease. Indian Parasitology Conference Meeting, polymorphisms in p16 gene are not associated with glioma risk Banaras Hindu University, Varanasi, UP, 21-23 January in Indian population. ISHG, Chennai, 3-5 March 2016. 2016. 288. Sinha Preeti. ECT- contemporary practice standards. Non- 282. Shruthi S, Gayathri N, Nalini A, Phalguni Anand Alladi, Raju invasive Brain Stimulation Symposium-2015, NIMHANS, TR. ALS-CSF induced altered trophic factor expression and Bengaluru, 20 September 2015. ultra-structural changes in the skeletal muscle of rat neonates. IISc-CBR Conference, IISc, Bengaluru, 16-18 November 289. Sinha S. (i) (a) Source imaging as a pre-surgical tool (b) 2015. Role of PET, SPECT, fMRI and MEG. Epilepsy Conclave 2015, Chennai, 31October-1 November 2015 (ii) Valproate 283. Shukla D, Kayanush P. (i) ICP Monitoring. Annual Conference - in idiopathic generalized epilepsy. Sodium Valproate IES of Indian Society of Critical Care Medicine, Bangalore, 2015 Consensus - Phase II, Mumbai, 28-29 November 2015 (iii) (a) (ii) ICP Monitoring. Annual Conference of Indian Society of Interesting video-DRE (b) MEG in Epilepsy: Does it improve Cerebrovascular Surgery, Ludhiana, 2015. the outcomes. Neurocon 2015, Hyderabad, 16 December 2015.
284. Shukla D. (i) Predictive validity of disability rating scale. 290. Sinu E (i) Clinical social work practice - An Update. Dept. of Annual Conference of Neurotrauma Society of India, Psychiatric Social Work, NIMHANS, Bengaluru, 29 July 2015 Bengaluru, 2015. (Best Poster Award) (ii) Parents reported (ii) Learning from best practices. Psychiatric Rehabilitation outcome in craniosysnostosis. Annual Conference of Indian Services, Dept. of Psychiatry, NIMHANS, Bengaluru, 19 Society of Pediatric Neurosurgery, Kochi, 2015 (iii) Endoscopic September 2015 (iii) Human rights education for social work transcortical transventricular placement of ommaya practice. School of Social Work, Roshini Nilaya, Mangalore, reservoir in cystic craniopharyngioma. Annual Conference 4-5 March 2016. of Neuroendoscopy Group of India, Bengaluru, 2015 (iv) Craniosynostosis. KG Medical College for Neurosurgery and 291. Sisira S, Satyanarayana VA. Marital satisfaction and Plastic Surgery faculties and students, 2015 (v) Aggressive psychological distress in Women with primary infertility. management of cerebrovascular vasospasm. Annual conference National Conference on Motherhood and Mental Health, of Indian Society of Cerebrovascular Surgery, Ludhiana, 2015 NIMHANS, Bengaluru, 31 October 2015. (vi) Coma arousal therapy for traumatic brain injury. Annual conference of Indian Federation of Neuro-rehabilitation. 292. Sivakami S, Kanitha D, Ramachandra, Lalitha K. Patients’ Bengaluru, 2016 (vii) Predictive validity of disability rating satisfaction on nursing care among head injury patients. 24th scale in determining functional outcome after traumatic brain Annual National Conference of Neurotrauma Society of India, injury. Indian Society of Neurosanesthesiology and Critical Bengaluru, NIMHANS, Bengaluru, 21-23 August 2015 (1st Care, Bengaluru, 2016. (Best Poster Award). Prize for Paper Presentation).
285. Shweta B, Supraja TA, Chandra P, Desai G, Jangam K, 293. Sivakumar PT, Agarwal M, Nagalakshmi RM, Satyanarayana VA, Venkatram L. What do women feel about Venkatasubramanian G, Bharath S, Saini J, Varghese M. psychosocial assessments as part of routine antenatal care? Hippocampal volume in late onset depression: A voxel based National Conference on Motherhood and Mental Health, morphometric study. 11th Annual National Conference of the NIMHANS, Bangalore, 31 October 2015. Indian Association for Geriatric Mental Health, Vadodara, 11- 13 September 2015. 286. Shwetha Chiplunkar, Kothari Sonam, Parayil Sankaran Bindu, Arun B Taly, Narayanappa Gayathri, Srinivas 294. Sivakumar PT. (i) Managing behavioral and psychological Bharath MM, Madhu Nagappa, Rakesh Kumar, Sanjib symptoms in dementia. Alzheimer’s and Related Disorders Sinha, Hanumanthapura R Arvinda, Periyasamy Govindraj, Society of India, Bangalore Chapter Support Group Meeting Paramsivam A, Thangaraj K. Mitochondrial disorders due for Caregivers, Bangalore, 25 July 2015 (ii) Management of to POLG2 mutation – A phenotypic, pathological and behavioural symptoms in dementia. Indian Psychiatric Society biochemical study. IANCON 2015, Agra, 1-4 October Karnataka Chapter PG CME, Dharwad, 10 January 2016 (iii) 2015. Research advances in Geriatric Depression ‐ Indian Perspective. 68th Annual National Conference of Indian Psychiatric Society 287. Sibin MK, Ch Lavanya, Chetan G K, Dhananjaya I (ANCIPS), Bhopal, 21-24 January 2016.
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295. Sivakumar T, Jagannathan A, Waghmare A. Caregiver Neurotrauma Society of India, Bengaluru, 21-23 August 2015. educational and support groups: NIMHANS initiatives and experiences. National Conference of Indian Association for 302. Soundarya Soundararajan. Genetics and epigenetics of alcohol Social Psychiatry, Agra, 6-8th November 2015. craving. World Psychiatric Association Congress, Kochi, 25-27 September 2015. 296. Sivakumar T, Swarupa U, Nirmala BP. Didactic presentation: Psychiatric disability and welfare benefits. VNK, NIMHANS 303. Sowmyashree Mayur Kaku, Pooja Panchal, Salah Basheer. ECHO: Road to Recovery (R2R), NIMHANS, Bengaluru, 26 Family as Co-therapist. Workshop on Autism, 13th Biennial June 2015. Conference of Indian Association of Child and Adolescent Mental Health Conference (IACAMCON), Pune, 19-21 297. Sivakumar T. (i) (a) Recovery oriented services: NIMHANS November 2015. experience. (b) Psychiatric Rehabilitation and Concept of recovery. Workshop on Psychiatric Rehabilitation for Mental 304. Sriganesh K. (i) Moderated the panel discussion on brain Health Professionals and Students, IMHANS, Kozhikode, 11 tumors. 1st Onco-anaesthesia Conference, Bengaluru, 1-2 April 2015 (ii) Challenges faced, Lessons learned and road August 2015 (ii) Internet resources to improve knowledge and ahead. Symposium on Caregiver Educational and Support practice. 31st South Zone Conference of the Indian Society Groups: NIMHANS Initiatives and Experiences. National of Anaesthesiologists, Trivandrum, 6-9 August 2015 (iii) Conference of Indian Association for Social Psychiatry 2015, Pregnant patients with intracranial space occupying lesion Agra, 6-8 November 2015 (iii) Sexual problems in individuals posted for Craniotomy: Anaesthetic implications. 63rd National with disabilities and their management. Workshop on Conference of the Indian Society of Anaesthesiologists, Jaipur, Cognitive Behavior Therapy in Sexual Dysfunctions, Dept. of 26-29 December 2015. Clinical Psychology, NIMHANS, Bengaluru, 7 January 2016 (iv) Beyond respite care/Vocational training. Symposium on 305. Srikala Bharath. (i) Making Mental Health Count. School Daycare as Rehabilitation Tool in Psychiatry, Annual National Mental Health Program in India, 25th Annual Conference (Silver Conference of Indian Psychiatric Society, Bhopal, 24 January Jubilee) of the India Psychiatry Society, Karnataka Chapter 2016 (v) Psychiatric rehabilitation: Meaning, principles and (IPS -KC), Shivamogga, 30 August 2015 (ii) Life Skills and therapeutic implications. National Workshop on Nurses role in Counselling. National Seminar on Refining and Redefining Psychiatric Rehabilitation Services, NIMHANS, Bengaluru, 5 Counselling, University of Trivandrum, Kerala, 11-12 February March 2016. 2016 (iii) School mental health: Needs and scope. 13th Biennial Conference of Indian Association of the Child and Adolescent 298. Smita Rawat, Gautham MS, Surendra VHH, Gururaj G. Mental Health, AFMC, Pune, 19-21 November 2015 (iv) Assessment of health systems and services including availability Depression: Its fallout and how to overcome it. Workshop on of components for mental health care in industries of Kolar Stress Management for the High Court Justices, National Judicial District. OCCUCON-2016, 66th Annual National Conference Academy, Bhopal, 27-28 February 2016 (v) Household cost of Indian Association of Occupational Health, Bengaluru, 19 of dementia in India. 19th National Conference of Alzheimer’s February 2016. and Related Disorders Society of India (ARDSI), Mumbai, 4-5 December 2015 (vi) Work pressure, Stress and mental health. 299. Somadatta Ray, Ravinder Jeet Singh, Dwarkanath Srinivas, Training Course for prosecutors of CBI, undersecretaries, deputy Ravi Yadav, Pramod Kumar Pal. Refractory status dystonicus in secretaries, directors of DOPT, National Judicial Academy, ataxia telangiectasia. MDSICON 2016, Chennai, 8-10 January Bhopal, 26-30 March 2016. 2016. 306. Srinath Shoba. (i) Dialogues in the clinic-At the interface of 300. Sonal Mathur. Cognitive behaviour therapy for social anxiety science and clinical medicine. Mini- Symposium, Institute disorder. Behaviour Medicine Unit, Department of Clinical for Stem Cell Biology and Regenerative Medicine-NCBS, Psychology, NIMHANS, Bengaluru, 27-28 November 2015. Bangalore, 13 August 2015 (ii) Awareness and necessity of early intervention. Roopa Shivakumar Annual Memorial Seminar, 301. Sonia Bansal. (i) Sedation for outside OT procedures (CT, Bengaluru, 7 November 2015 (iii) Parenting from art to MRI, Endoscopy). CME on Paediatric Anaesthesia, Apollo science- a journey of parenthood. Biennial Conference of the Hospital, Bangalore, 19 July 2015 (ii) The incidence and Indian Association of Child and Adolescent Mental Health, risk factors for hypofibrinogenemia in patients undergoing IACAMH 2015, Pune, 20 November 2015 (iv) Attention surgery with traumatic brain injury. 24th Annual Conference of Deficit Hyperactivity Disorder. CME, Spandana Nursing
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Home, Bengaluru, 27 November 2015 (v) Pediatric obsessive Indian Society of Anesthesiologists, Andhra Pradesh Chapter, compulsive disorder. ANCIPS 2016, Child Psychiatry Section, Rajahmundry, 31October-1 November 2015. Bhopal, 24 January 2016. 315. Sugavana Selvi, Psychiatric problems in relation to traumatic brain 307. Srinibash Sahoo. (i) Clinical evaluation of Brahma Rasayana injury. 24th Annual National Neuro Trauma Conference, Nursing in the management of Manasa Mandata, NIMHANS Faculty Department, NIMHANS, Bengaluru, 21-23 August 2015. Meeting, Bengaluru, 17 February 2016 (ii) Nasya karma. CME on Panchakarma for Ayurveda Doctors, SDM College of 316. Suhas G, Abhishekh HA, Kumar CN, Thirthalli J. Systematic Ayurveda, Hassan, 23 February 2016. review and meta-analysis of Indian community based studies on metabolic syndrome in patients with schizophrenia. DECADE 308. Srinivas Bharath MM. (i) (a) Depicting results in a scientific Conference, Thirthahalli, 12 December 2015. manuscript (b) Materials, Methods and Statistics. Workshop on Writing a Scientific Article for Publication, Sri Devaraj Urs 317. Sulakshana MS, Deepti SP, Siddiq M Ahmed, Dayananda S Academy of Higher Education and Research (SDUAHER), Biligi. Ectopic adrenal gland in undescended testis in an adult - Kolar, 5 March 2016. A case report. PathFest Symposium Series-Bengaluru Chapter, St. Martha’s Hospital, Bengaluru, 8-9 August 2015. 309. Sruthi U, Padmanabhan B. Pharmacophore based screening methodology for inhibition of Keap1. Molecules in Living 318. Sumathi R. Pattern of adjustment of rural school children Cells: Mechanistic Basis of Function, Annual Meeting of in Karnataka. Conference on Social Work and Sustainable Indian Biophysical Society, Bengaluru, 8-10 February 2016. development, Dept. of Social Work and Central University of Rajasthan, 24-26 February 2016. 310. Subhadeep Dutta Gupta, Shankaranarayana Rao BS, Bindu M Kutty. (i) Ventral subiculum and hypothalamus: Implications 319. Suman LN. (i) Future research in clinical psychology in on circadian behaviors in rodents. Proceedings of 33rd Annual India. IACP Symposium on History of Clinical Psychology Conference of Indian Academy of Neurosciences (IAN2015), in India, Centenary Conference on Psychology, University Panjab University Chandigarh, 31October - 2November 2015 of Calcutta, Kolkata, West Bengal, 9-11 October 2015 (ii) (ii) Ventral subiculum: Role in anxiety behavior, TS Srinivasan Research trends in addictive behaviors. National Seminar on - Knowledge Conclave 2016, An Interdisciplinary Workshop Substance Abuse and Addiction Recovery (SAAR, 2016) UGC for Clinicians and Scientists on Cognition and Dementia, sponsored, Department of Psychology, MES College, Aluva, NIMHANS, Bengaluru, 12-13 February 2016. Kerala, 23 January 2016 (iii) Life skills training for prevention of addictive behaviours. Seminar on Life Skills, Samadhan 311. Sudhakar D. Achievements and Activities of Advanced Centre Centre for Counseling and Life Skills, Bengaluru, 31 January for Ayurveda. NIMHANS Faculty Meeting, Bengaluru, 17 2016 (iv) Spiritual perspective. Panelist for a Panel Discussion: February 2016. Integration of Spiritual Perspective in Psychotherapy. National Conference on Alternative Perspectives in Psychotherapy- 312. Sudhir PM. Metacognitive therapy in emotional disorders: Insight: 2016, Dept. of Psychology, Kristu Jayanti College, Different or same from CBT and mindfulness? In Symposium Bengaluru, 2-3 February 2016. on Contemporary Cognitive Behaviour Therapies for Emotional Disorders: Application of Trans Diagnostic 320. Sundar Periyavan, Sukanyaaruah, Sangeetha K Seshagiri, Approaches, 42nd National Annual Conference of the Indian Shivanna N, Vivekanad J, Shanthi P. Safety and efficiency Association of Clinical Psychologists (NACIACP), Imphal, of small volume plasmapheresis in children: Experience in Manipur, 24-27 February 2016. a Tertiary Neuroscience Centre. 40th Annual Conference of Indian Society of Blood Transfusion and Immunohematology, 313. Sudhir Venkataramaiah, Bharath Vinay, Dhaval Shukla. New Delhi, 25-27 September 2015. Retrospective study of perioperative factors affecting neurological outcome in surgically treated traumatic extradural hematoma. 63rd 321. Sunder P, Tyagi V, Dharmappa AS, Keshav Kumar KJ, Annual Conference of the Indian Society of Anesthesiologists, Thirthalli J, Mehta UM, Shyamsundar A, Gangadhar BN, ISACON 2015, Jaipur, 25-29 December 2015. Chaturvedi SK. Augmentation of Cognitive Remediation Training (CRT) with repetitive transcranial magnetic 314. Sudhir Venkataramaiah. Anesthetic management of posterior stimulation: Impact on cognitive functions and symptoms in fossa tumors. ISAAPCON 2015, Annual Conference of the patients with schizophrenia. 1st Symposium on Non Invasive
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Brain Stimulation, NIMHANS, Bengaluru, 20 September psychosocial needs pertaining to quality of life among persons 2015. with first episode psychosis. Workshop on Quality of Life in Chronic Mental Illnesses: Exploring New Frontiers. Dept. 322. Sunitha TS. Prediction on prognosis on traumatic brain of Psychiatric Rehabilitation, NIMHANS, Bengaluru, 30 injury by clinical nurses. 24th Annual National Neuro Trauma January 2016. Conference, Dept. of Nursing, NIMHANS, Bengaluru, 21-23 August 2015. 331. Swarupa UM, Shari MT, Nirmala BP. (i) (a) Cultivate Inclusion (b) Family Involvement for ADL training in Neurological 323. Sunitha TS, Padmavathy N, Jothimani. (i) (a) Stem cell and Rehabilitation. International Day for Persons with Disabilities, nanotechnology approaches in neuro trauma (b) Misconception Dept. of Psychiatric Social Work, NIMHANS, Bengaluru, 3 about traumatic brain injury among Nursing students (c) A December 2015. study to assess the knowledge on GCS among under graduate Nursing student. 24th Annual National Neuro Trauma 332. Tanakanti Sreedhar, Birudu Raju, Srikanth Reddy V. Conference, Dept. of Nursing, NIMHANS, Bengaluru, 21-23 Promotion of health and mental health of elderly population. August 2015. National Conference on Healthy Aging a Life Span Perspective, Srivenkateswara University, Tirupathi, 10-11 324. Supraja S. Chandra PS, Desai G, Satyanarayana V, Jangam K. March 2016. Correlates of antenatal attachment among pregnant women. National Conference on Motherhood and Mental Health, 333. Thanza KA, Ragesh G, Ameer Hamza, Harish T, Geetha NIMHANS, Bengaluru, 31 October 2015. Desai, Prabha Chandra. The reunion – Case report. National Conference on Motherhood and Mental Health, NIMHANS, 325. Supraja TA, Chandra P, Desai G, Jangam K, Satyanarayana Bengaluru, 31October 2015. VA, Thennarasu K, S Thomas & Venkatram L. Mental health correlates of antenatal attachment among pregnant women 334. Thomas Gregor Issac, Chandra SR, Nagaraju BC, Utility of (poster presentation). National Conference on Motherhood TMS as an Early biomarker to differentiate between cortical and Mental Health, NIMHANS, Bengaluru, 31 October 2015. dementia, IISc, Bengaluru, 17-19 November 2015.
326. Suseela T. A Study to assess the effectiveness of educated 335. Tiwari SK. Practical approach on cause of CVD and program on shaken baby syndrome among primi postnatal management of stroke. Centre for Traditional Medicine and mother. 24th Annual National Neuro Trauma Conference, Research, Chennai, 8 August 2015. Dept. of Nursing, NIMHANS, Bengaluru, 21-23 August 2015. 336. Tripathi SJ, Suwarna Chakraborty, Srikumar BN, Raju 327. Sushruth Nageshkumar, Neurological and functional recovery TR, Shankaranarayana Rao BS. Inactivation of basolateral in patients with transverse myelitis with inpatient rehabilitation amygdala ameliorates chronic stress-Induced cognitive deficits and their MR imaging correlates. National IAPMR Mid-Term by preventing structural and molecular alterations in the CME, Srinagar, Jammu and Kashmir, 18-20 September 2015. prefrontal cortex. 33rd Annual Conference of Indian Academy of Neurosciences (IAN2015), Panjab University, Chandigarh, 328. Sutar R, Yadav S, Ganjekar S, Desai G, Chandra P. Infant health 31October -2 November 2015. in mothers with severe mental illness during postpartum period admitted to Mother Baby Ward -A chart review. National 337. Tripathi SK, Shruti M, Prashant D, Padmanabhan, B. Conference on Motherhood and Mental Health, NIMHANS, Identifying BD2 specific inhibitors using rational structure Bengaluru, 31 October 2015. based approach. Molecules in Living Cells: Mechanistic Basis of Function, Annual Meeting of Indian Biophysical Society, 329. Suwarna Chakraborty, Sunil Jamuna Tripathi, BN Srikumar, Bengaluru, 8-10 February 2016. TR Raju, Shankaranarayana Rao BS. Amelioration of depression-induced cognitive deficits by chronic N-Acetyl 338. Tyagi, V. (i) Disability assessment in mental retardation. cysteine treatment. 33rd Annual Conference of Indian Academy Sensitization Programme for District Disabled Welfare of Neurosciences (IAN2015), Panjab University, Chandigarh, Officers of Karnataka, Bengaluru, 15 December 2015 (ii) 31October - 2 November 2015. Social skills assessment. Social Skills Assessment and Training: NIMHANS- ECHO Road to Recovery, Virtual Knowledge 330. Swarupa UM, Nirmala BP, Jagadisha T. Exploring the Network, NIMHANS, Bengaluru, 29 January 2016.
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339. Uma Hirisave, Snigdhasree Bhattacharyya, Anupama 344. Veena Satyanarayanan, Poornima Mahindru. Mothers with Vijayaraghavan. (i) Addressing and handling mental health borderline personality disorders and their Infants. National issues of adolescents. Workshop for Pre University Teachers, Conference on Motherhood and Mental Health, NIMHANS, St. Josephs PU College, Bengaluru, 29 July 2015 (ii) Bengaluru, 31 October 2015. Promoting mental health using life skills approach. Dept. of Psychiatric Social Work, NIMHANS, Bengaluru, 7-8 345. Vidhyasagar K, Manjula M. Case demonstration on sexual September 2015. dysfunction. Workshop on Cognitive Behaviour Therapy in Sexual Dysfunctions, Dept. of Clinical Psychology, 340. Umamaheswara Rao GS. (i) (a) Anaesthetic management NIMHANS, Bengaluru, 7-8 January 2016. of a patient with epilepsy (b) Neuromuscular diseases and anaesthesia. Annual Conference of the Indian College of 346. Vidhyasagar K, Manjula M. (i) Emotion regulation skills (reactive Ananesthetists, Chennai, 12 November 2015 (ii) Challenges to reactive). Workshop on Emotion Regulation for Healthy Living, in paediatric neurocritical care. ISNACC Annual Conference NCWB, NIMHANS, Bengaluru, 27 October 2015. 2016, NIMHANS, Bengaluru, 5-7 February 2016. 347. Vidyadhara DJ. Aging causes morphological alterations 341. Valliammal S. (i) (a) Awareness and prevention of shaken in astrocytes and microglia in human substantia nigra pars baby syndrome (b) Brain injury rehabilitation – A step ahead. compacta. 61st National Annual Conference of Association of 24th Annual National Neuro trauma conference, Nursing Physiologists and Pharmacologists of India, AIIMS, Jodhpur, Department NIMHANS, Bengaluru, 21-23 August 2015. 26-28 December 2015 (BK Anand Award: Best Paper)
342. Vani Santosh. (i) (a) Pathology of gliomas - An update 348. Vijaya Lakshmi S. (i) Preventive levels of traumatic brain injury and pathology of pediatric brain tumor, Glioneuronal (ii) Nursing students Knowledge attitude and practice related to tumors. CME in Neuropathology (b) Neoplasms of CNS. organ donation (iii) Caregivers burden of traumatic brain injury Slide Seminar on Neoplastic and Non Neoplastic CNS patients. 24th Annual National Neuro Trauma Conference, Lesions, Victory Path 2015, Government Medical College, Nursing Department NIMHANS, Bengaluru, 21-23 August Thiruvanathapuram, 11-12 April 2015 (ii) Pathology of adult 2015. and pediatric brain tumors. Slide Session in Neuropathology, 1st Pathology CME, Sri Venkateswaraa Medical College 349. Vijayalakshmi K. Cellular models for ALS research at Hospital and Research Centre, Puducherry, June 2015 (iii) NIMHANS. University of Liverpool –NIMHANS Recent insights in molecular pathology of paediatric gliomas Symposium, Bengaluru, 29 September - 1 October 2015. and their likely impact in the upcoming WHO classification. KMIO – TMC Paediatric Neuro-Oncology CME, KMIO, 350. Vijayalakshmi Poreddi, Sailaxmi Gandhi. Undergraduate Bengaluru, July 2015 (iv) Update on Gliomas and Slide nursing students’ knowledge and attitude towards organ session in Neuropathology. Pathology PG Training Workshop donation. Satellite Conference of Neurotrauma Nursing 2015 (CALIPATH 2015), Government Medical College, Calicut, with the 24th Annual Conference of NTSI 2015, Bengaluru, October 2015 (v) Gliomatosis cerebri. Clinicopathological 21-23 August 2015. Conference, Neurological Society, Bengaluru, December 2015 (vi) Towards a histomolecular classification of gliomas. 351. Vikas V. (i) Framework for cognitive surgical robotics: A NPSICON, Hyderabad, December 2015 (vii) Classification neurosurgery perspective. Indo-Global Healthcare Summit of pituitary adenomas -What is new. Sixth Annual Karnataka and Expo 2015, Hyderabad, Telangana, 23-26 July 2015 (ii) State Neurosciences Academy Conference [KNACON] 2016, An MDP model for management of intracranial pressure. Gulbarga, 29-31 January 2016 (viii) Molecular pathology of ISNACC, NIMHANS, Bengaluru, 5-7 February 2016. gliomas. CME in Neurooncology, Shankara Cancer Hospital and Research Center, Bengaluru, February 2016. 352. Viswanath B. (i) Cellular models in psychiatry. 68th Annual National Conference of Indian Psychiatric Society, Bhopal, 21- 343. Varambally S, Gangadhar BN. (i) Yoga for Psychosis. 48th 24 January 2016 (ii) Chronobiology of bipolar disorder. National Annual Conference of the IPS, South Zone, (IPSOCON), Conference on Chronobiology and Health, Pondicherry, 18-19 Nellore, Andhra Pradesh, 16-18 October 2015 (ii) Yoga For March 2016. Schizophrenia - Past, present, and future. 68th Annual National Conference of Indian Psychiatric Society (ANCIPS), Bhopal, 353. Vivek Benegal. (i) Treatment of cannabis addiction. 16th Madhya Pradesh, 21- 24 January 2016. Annual National Conference of Indian Association of Private
National Institute of Mental Health and Neuro Sciences 307 Annual Report 2015-2016
Psychiatry, Khajuraho, 3-6 December 2015 (ii) State of the 1-Methyl-4-Phenyl 1,2,3,6-Tetrahydropyridine (MPTP) art: Externalizing disorders. Workshop on Neuroimaging resistant and susceptible mice strains and their crossbreds. 33rd - What the Neuro-Psychiatrist Should Know, Behavioral Annual Meeting of the Indian Academy of Neurosciences, and Neuroscience Academy of India, Hyderabad, February Panjab University, Chandigarh, 31 October -2 November 2015. 2016 (iii) (a) Translating recent knowledge into treatments (b) Neurobiology and genetics of Addiction. CME on 362. Yasha TC. (i) Debate ADEM and NMO/MS can be clinically/ Neurobiology of Addiction, Srinagar, January 2016. radiologically/ pathophysiologically differentiated, versus both an extended spectrum of same disease. Neuro Vision- 354. Vivek Rayadurg, Bhadrinarayan V, Gopalakrishna KN. Delayed Neurology beyond Guidelines, New Delhi, May 2015 (ii) complication of temporal craniotomy leading to potentially Recent trends in neuroanatomy and neurophysiology. CME, difficult airway. Neurotrauma 2015, 24th Annual National BGS Global Institute of Medical Sciences, Bengaluru, May Conference of NeuroTrauma Society of India, NIMHANS, 2015 (iii) Neuropathology case discussion - Emerging from the Bengaluru, 21-23 August 2015. shadows, KAPICON 2015, Vijayapura, 12-14 June 2015 (iv) Neuropathology of Parkinson’s disease. MDSICON 2016, The 355. Vivek Rayadurg, Radhakrishnan M, Umamaheshwara Rao GS. First National Conference of the Movement Disorders Society Isoflurane as a novel therapeutic agent in a case of refractory of India 2016, Chennai, 8 January 2016. myoclonic status epilepticus. ISACON 2015, 63rd Annual Conference of the Indian Society of Anesthesiologists, Jaipur, 25-29 December 2015. Resource Persons
356. Vivek Rayadurg, Shweta Naik, Bhadrinarayan V. Heart rate 1. Aarti Jaganathan (i) Rehabilitation in homeless mentally ill. variability as a predictor of infection and organ dysfunction National Moderated Virtual Knowledge Network (VKN)- in neurological patients. ISNACC 2016, Bengaluru, 5-7 ‘Road to Recovery (R2R)’, Psychiatric Rehabilitation Services February 2016. (PRS), NIMHANS, 28 August 2015 (ii) Clinical services in psychiatric rehabilitation unit and visit. Regional workshop on 357. Vranda MN. Promotion of mental health and well-being of Recent Trends in Psychiatric Social Work for MSW students adolescents in schools using life skills education. ISPSW National of Madurai Institute of Social Work, 24 September 2015 Conference on Social Work and Sustainable Development, (iii) Rehabilitation of persons with mental illness. National Central University of Rajasthan, 24-26 February 2016. workshop on Advanced Training Programme on Mental Health, Action Aid, Jammu and Kashmir, 30 September 358. Vrinda M, Arun S, Kala P Nair, Srikumar BN, Bindu M Kutty 2015 (iv) Clinical services in psychiatric rehabilitation centre and Shankaranarayana Rao BS. Novel therapeutic stratergies to and skills training on vocational rehabilitation planning treat epilepsy-induced cognitive deficits. 33rd Annual Conference and management. Regional Workshop for MSW students, of Indian Academy of Neurosciences (IAN2015), Panjab Kristu Jayanthi College, 10 December 2015 (v) Orientation University, Chandigarh, 31 October - 2 November 2015. to qualitative research. National workshop on Research Methodology in Psychosocial Issues, 10 February 2016 (vi) 359. Vrinda M, Arun S, Kala PN, Aparna S, Meghna S, BN Need for psychiatric rehabilitation. Regional workshop for field Srikumar, Bindu M. Kutty, Shankaranarayana Rao BS. Novel staff from Association for Persons with Disability (APD) on therapies to treat epilepsy-induced neurodegeneration and Mental Health, 17 March 2016. cognitive deficits. 5th Annual Meeting of Indian Academy of Biomedical Sciences. Theme: Biomedical Sciences in 21st 2. Ahalya Raguram. Overview of family therapy. Orientation Century and Beyond, The Medicity, Medanta, New Delhi, 26- programme on Clinical Psychology: Promoting Mental Health, 28 February 2016. for postgraduate students of psychology, NIMHANS, 5- 6 February 2016. 360. Yadav S, Saranya D, Shayanth M, Desai G, Chandra P. Prescription patterns of psychotropics in women with bipolar 3. Aravind Raj E (i) Life skills education. State training program on disorder. National Conference on Motherhood and Mental Adolescent Counselling for Higher Secondary School Teachers, in Health, NIMHANS, Bengaluru, 31October 2015. collaboration with Child Guidance and Adolescent Counselling cell, Dept. of Higher Secondary Education, Govt. of Kerala, Dept. 361. Yarreiphang H, Vidyadhara DJ, Raju TR, Phalguni Anand of PSW, NIMHANS, 1-2 April 2015 (ii) PSC for children in Alladi. Differential expression of apoptotic markers in difficult circumstances and life skills education, State School Mental
308 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Health Program for staff of SCARF, Dept. of PSW, NIMHANS, 5. Basavarajappa C. Marriage and mental illness. Training Camp 16-17 April 2015 (iii) Community based interventions. Two- on Mental Health for Persons with Mental Illness and their day State Mental Health Enrichment training for community Caregivers, Kodadagudda, Davangere, 29 December 2015. differently abled welfare facilitators of Pudhu Vaazhvhu Project, Govt. of Tamil Nadu, Dept. of PSW, NIMHANS, Bengaluru, 6. Bhola P. (i) workshop on Cross-cultural Issues and the (a) 17 April 2015 (b) 29 May 2015 (iv) National Psychosocial Assessment & Measurement of Quality of Life in Mental Care for men and women in disasters in gender and disaster, Illnesses. Symposium on Quality of Life in Chronic Mental NIDM, New Delhi, 14 May 2015 (v) National psychosocial care Illness: Exploring New Frontiers, NIMHANS, Bengaluru, for children in disaster Training Programme on Children and 30 January 2016 (ii) VKN Training Programme: Social skills Disaster Management, NIDM, New Delhi, 16 July 2015 (vii) assessment and training, NIMHANS, Bengaluru, 29 January Mental health and psychosocial care during and after disasters. 2016 (iii) Volunteers Sensitization Programme, NIMHANS State Training Programme on Health Care Management During Centre for Wellbeing (NCWB), Bengaluru, 1 August 2015 Disasters, 23 July 2015 (viii) Introduction to ICD & ICF, Regional (iii) workshop on Non-suicidal Self-injury: Assessment Office for Health and Family Welfare, Bengaluru, (a) 24 July 2015 and Intervention Frameworks. 13th Biennial Conference of (b)13 August 2015 (c) 11 September 2015 (d) 14 October 2015 Indian Association of Child and Adolescent Mental Health (ix) Disaster Mental Health: Recent Trends in Psychiatric Social (IACAMCON), AFMC, Pune, Maharashtra, 19-21 January Work for Madurai Institute of Social Sciences, Dept. of PSW, 2016 (v) workshop on Basic Skills for Counselling Youth, NIMHANS, 26 September 2015 (x) Marital Disharmony— NCWB, Bangalore, 7 November 2015 (vi) Programme on Recent Trends in India: Causes and prevention. 48th Annual team-building in nursing. Workshop on Leadership Skills & National Conference of Indian Psychiatric Society-South Zone, Nursing Team Building, NIMHANS, Bengaluru, 30 September Narayana College, Nellore, Andhra Pradesh, 16 October 2015 2015 (v) Workshop on Psychotherapy Process and Research; (xi) Mental health and psychosocial care for women, disabled Process Variables in Practice, Manipal University, Manipal, 21- and aged persons. State Training Programme on Health Care 22 August 2015 (vi) Workshop on Workplace Mental Health. Management during Disasters in ATI, Mysore, 2 November 2015 GE Global, Bangalore, Karnataka, 11-12 August 2015. (xii) International Classification of Functioning, Disability and Health TOT/Workshop (a) Psychiatry Update 2015 CME, Dept. 7. Bino Thomas. (i) Problem solving and empathy skills. Regional of Psychiatry, KMC, Manipal, 15 November 2015 (b) Regional Skill Building Programme, for the students of Mount Carmel Office for Health and Family Welfare, Bengaluru, 19 November Seminary, 30 December 2015 (ii) Counseling skills for the suicide 2015 (c) Vydehi Institute of Medical Sciences, Bengaluru, 27 prevention for the trainers and superintendents. Indian Aerospace November 2015 (d) Regional Office for Health and Family Medicine, Bengaluru (a) 20 January 2016 (b) 16 March 2016. Welfare, Bengaluru, 7 January 2016 (e) Sree Raja Rajeshwari Medical College, Bengaluru, 4 March 2016 (xiii) State Mental 8. Chandran D. Neuropsychological assessment. 5th National Health and Psychosocial Care During and After Disasters, Workshop on Neuropsychological Assessment and Mental Health & Psycho-Social Need Assessment Presentation, Rehabilitation: Roots to Fruits 2015 (NANR-RF 2015), Special Needs of Women, Old Aged and Disabled in Disaster – Part of Continuing Education in Neuropsychology (CEN), Listing & Presentations, ATI, Mysore, 20 January 2016 (xiv) State Clinical Neuropsychology Unit, Dept. of Clinical Psychology, Life Skills Education, Psychosocial care for children in conflict NIMHANS, Bengaluru 16-18 July 2015. with law in Kerala in collaboration with Dept. of social justice, Govt. of Kerala, Dept. of Psychiatric Social Work, 21 January 9. Fatema Khanam. Cognitive behaviour therapy: principles and 2016 (xv) Training, Monitoring, Evaluation and Supervision, applications. Behaviour Medicine Unit, Department of Clinical State Training Program for Volunteers of Yuva Spandana, Dept. Psychology, NIMHANS, Bengaluru, 9-10 July 2015. of Epidemiology, NIMHANS, (a) 27 January 2016 (b) 3 March 2016 (xvi) School Mental Health Program. Session for school 10. Gobinda Majhi, (i) Regional skill training on Psychiatric Disability children of GHPS, Chandapura, Sansera Engineering Pvt. Ltd, 2 Assessment in Recent Trends in Psychiatric Social Work, 9 March 2016 (xvii) Psychosocial care in disaster management. State December 2015 (ii) Regional symposium on Disability and Workshop on Psychosocial Care in Disaster Management, ATI, Inclusion, 3 December 2015 (iii) Scientific Sessions on Wellbeing, Mysore, 22- 23 March 2016. 34th Annual National Conference of the Indian Society of Professional Social Work (ISPSW), 24-26 February 2016. 4. Basavarajappa C, Thirthalli J. Rehabilitation in institution setting. Proceedings of the Road to Recovery, Virtual Knowledge 11. Hargun Ahluwalia. Brief interventions for addictions. Capacity Network, NIMHANS- ECH, Bengaluru, 26 June 2015. building workshop on Psychological Approaches to Addictive
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Behaviors, Dept. of Clinical Psychology, NIMHANS, 2015 (xiv) Measurement issues in social science research. Bengaluru, 21 November 2015. National Research Workshop, Bengaluru, 8 February 2016 (xix) Psychosocial issues in adoption. Symposium, College of Nursing, 12. Hegde S. (i) Caring for the elderly: Cognitive remediation NIMHANS, 11 March 2016. in early phase of dementia. 5th Continuing Education in Neuropsychology: National Workshop, NIMHANS, Bengaluru, 15. Jayakumar C. (i) Psychosocial support in disaster management. 16-18 July 2015 (ii) Music and the brain-Neuroscientific Disaster and emergency management workshop, Karnataka perspective on music therapy. 4th National Seminar on Music State Fire and Emergency Services Department, Bengaluru, 25 Therapy, Sur Sanjeevan Music Therapy Forum, Dinanath November 2015 (ii) Psychosocial care interventions in disaster. Mageshkar Hospital and Research Center, Pune, 23 August Orientation programme to NGOs in Pondicherry, 29 December 2015 (iii) Meeting of science & art: Neuroscience of music 2015 (iii) Psychosocial care in disasters. One day orientation on therapy. Swarohan in collaboration with Hamsakutira (Socio- Psychosocial Care in Disaster Management, PG students and cultural Public Trust working serving the public through Music), faculty, Chennai (a) 10 December (b) 21 December 2015 (c) 11 Bengaluru, 5 September 2015 (iv) Music and mental health. January 2016 (iv) The challenges and way forward for inclusion World Mental Health Day, The Richmond Fellowship Society of persons with disability in inclusion matters. Symposium on (India), Chetana Center, Bengaluru, 16 October 2015 (v) Music Disability and Inclusion, International Day for Persons with cognition and brain imaging. Seminar on Music & Medical Disabilities, Dept. of Psychiatric Social Work, NIMHANS, 3 Imaging - The Clinical Impact and Technological Perspective of December 2015. Music in Medical Imaging, Medimusictech in association with Mediscan Systems, Chennai, 20 December 2015. 16. Jayanthi KN. (i) Team building in nursing: Bridges to the future, College of Nursing, NIMHANS, 30 September 2015 13. Jagadisha Thirthalli. CME on Electroconvulsive Therapy and (ii) Trends and legit concern in psychiatric nursing. 2nd National other Neurostimulation Therapies, Goa Psychiatric Society, conference on Crunch in Psychiatric Nursing, E.S. College of Goa, 25 October 2015. Nursing, Villupuram, Tamil Nadu, 8 January 2016 (iii) AWorld of New Challenges for the Clinical Nurse Specialist. National 14. Janardhana N. (i) Capacity building programme for the ICPS Conference on Rejuvenate Praxis, Saveetha College of Nursing, functionaries in the state of Karnataka. National workshop on Chennai, 5-6 February 2016 (iv) Clinical research in mental Baseline for Every Child, 9 May 2015 (ii) Role of teachers in health nursing. 15th Annual National ISPN Conference, dealing with the behavioural problems of children. Regional Krishna Institute of Nursing Sciences, Karad, Pune, 13-15 Symposium, Dept. of Nursing, NIMHANS 13 April 2015 February 2016. (iii) Personality development for the adolescent girls in the state home for girls, NIMHANS 15 June 2015 (iv) scrutinizing 17. Jeeva S. Home care, follow-up and growth monitoring of low applications seeking financial aid from the Department for birth weight babies. Pre-conference workshop on Care of Low Empowerment of Differently Abled and Senior Citizens, Govt. Weight Birth Babies, 6th Annual Conference of IANN, PSG of Karnataka, Bengaluru (a) 15 June 2015 (b) 27 June 2015 (v) College of Nursing, Coimbatore, 12 February 2016. Health and Mental Health. District Training Institute, Govt. of Karnataka, Bengaluru, 14 July 2015 (vi) Stress management for 18. John Vijay Sagar K. (i) Classroom management of behavioural Group C and Group D employees Undergoing Training, District problems (Panel discussion), Dept. of Nursing, NIMHANS, Training Institute, (a) 14 July 2015 (b) 5 December 2015 (vii) 13 April 2015 (ii) Workshop on Intervention Development Community based rehabilitation and people with intellectual for Co-Morbidities of ASD (PASS PLUS), Sangath, New disabilities and loco motor disability, Fame India, 21 July 2015 Delhi,7 April 2015 (iii) School Refusal and Child Sexual (viii) Understanding domestic violence and intimate partner Abuse. Child Psychiatry CME, IAP, Gulbarga, 21 June 2015 violence, NCWB, 22 July 2015 (ix) Psychosocial problems of (iv) Psychiatric disorders in adolescents. Life Skills Education juveniles and prevention. District Child Protection Unit, 23 July Workshop, NIMHANS, 25 June 2015 (v) Suicide prevention- 2015 (x) Mental health from development prospective. APD role of teachers, parents and counselors. National Workshop Board Meeting, Bengaluru, 19 August 2015 (xi) Prevention of on Promotion of Mental Health and Psychological Well- sexual abuse. Three-day workshop on Life Skill Education, 8 Being of Adolescents Using Life Skills Approach, Department September 2016 (xii) Emotional intelligence and its enhancement of PSW, NIMHANS, 8 September 2015 (vi) Child sexual for the newly recruited government employees, District Training abuse. Annual Conference of Indian Psychiatric Society, Institute, 5 December 2015 (xiii) Family psychiatric social work Central Zone (CIPCON-2015), Moradabad, UP, 11 October services. Recent trends in psychiatric social work, 11 December 2015 (vii) Academic underachievement. Midterm CME of
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Indian Psychiatric Society, Andhra Pradesh State branch, 9-10 July 2015 (iii) Cognitive behaviour therapy for social Sri Venkateswara Institute of Medical Sciences (SVIMS), anxiety disorder. Behaviour Medicine Unit, Dept. of Clinical Tirupati, 5 March 2016. Psychology, NIMHANS, 27-28 November 2015.
19. Kanappa Setty. Effective management of emotions for women 26. Muralidhar D. Interdepartmental Symposium on Learning with disability. Association of People with Disability (APD), from Best Practices in Disability Sector: Implications for Jeevanbhimangar, Bengaluru, 15 March 2016. Psychiatric Rehabilitation, 19 September 2015.
20. Kanika Malik. Marital counseling in addictions. Capacity 27. Murugappan NP. Supporting skills for training of yuva building workshop on Psychological Approaches to Addictive parivarthakas. Centre for Public Health, Dept. of Epidemiology, Behaviors, Dept. of Clinical Psychology, NIMHANS, 21 NIMHANS and Department of Youth Empowerment and November 2015. Sports, Government of Karnataka, Bengaluru, Karnataka, (a) 9 July 2015 (b) 20 November 2015 (c) 29 January 2016. 21. Kathyayani BV. (i) Role of nurse in rehabilitation of persons with dementia. Alzheimer’s Care Rehabilitation programme, 28. Narayanan G. (i) Group interventions and interviewing the ARDSI - Bethel Medical Mission, Bengaluru, 11 December patient. Tobacco Cessation Clinic, NIMHANS, 2015 (ii) 2015 (ii) Importance of team in nursing. Team building Motivational interviewing. One month training programme in nursing: Bridges to the future, College of Nursing, for substance use, CAM, NIMHANS, 7 November 2015 (iii) NIMHANS, 30 September 2015 (iii) Nursing care quality Communication skills training. One-month training programme indicators. Transforming care at bedside ameliorates patient on substance use, CAM, NIMHANS, 18 November 2015 (iv) care and improves vitality of health care team, College of Stages of behavioural change and motivation de-addiction Nursing, NIMHANS, 11-12 January 2016 (iv) History and treatment programme for doctors and counselors from State development of child adoption. Psychosocial issues and role of Health Society, Government of Bihar, 25 February 2016. a nurse in child adoption, College of Nursing, NIMHANS, 11 March 2016. 29. Pradeep Y. (1) Electrophysiology in hearing. Father Mullers College of Speech and Hearing, Mangalore, 6 April 2015 (ii) 22. Kavita Jangam, (i) Regional Childline. Volunteer training (a) Neuroaudiology- A clinical Perspective (b) Open source workshop on Child Sexual Abuse, 21-22 November 2015 (ii) software in diagnosing and rehabilitation-Central auditory Regional Child Sexual Abuse Awareness Programme (CSAAP), processing disorder. Annual Conference of Indian Speech and 26-27 September 2015 (iii) State-level training for Childline & Hearing Association, Tamil Nadu, Kanyakumari, 2-4 October DCPU staff, 27- 29 April 2015. 2015.
23. Krishna Reddy, (i) Regional workshop on Clinical Services in 30. Pratibha Swamy. (i) Role of Nurse in management of Neuro-surgery Unit and Skill Training on Enabling Patients peripheral nerve injuries. 24th Annual National Neuro Trauma and Families to Assess Welfare Benefits, 9 December 2015 Conference. Dept. of Nursing, NIMHANS, 21-23 August (ii) Inclusion Matters. Regional Symposium on Disability and 2015 (ii) Process of team building. Team building in nursing; Inclusion, 3 December 2015 (iii) Scientific Session, Regional Bridges to the future, College of Nursing, NIMHANS, 30 Symposium on Clinical Social Work Practice in Mental September 2015 (iii) Research designs in nursing. Research Health-An Update, 29 July 2015. Methodology, RGUHS, Bengaluru, 27 August 2015.
24. Mani RS. Science and utility of real-time PCR. National 31. Priya Baby. (i) Initiative steps in evidenced based practice in Conference on Advanced Research in Medical Science & nursing: An Indian scenario. Transforming care at bedside Workshop, Department of Microbiology, SRM Medical ameliorates patient care and improves vitality of health care team, College Hospital and Research Centre, Chennai, 28-29 College of Nursing, NIMHANS, 11-12 January 2016. September 2015. 32. Priya Treesa Thomas, (i) Regional Workshop on Participatory 25. Mathur Sonal. (i) Cognitive behaviour therapy: Principles and Methodology, Montfort College, Bengaluru 6- 13 November applications. Department of Psychiatry, Geetanjali Medical 2015 (ii) Regional Symposium on Clinical Social Work Practice College & Hospital, Udaipur, 18-19 April 2015 (ii) Cognitive in Mental Health -An Update, 29 July 2015 (iii) Psychiatric behaviour therapy: Principles and applications. Behaviour Social Work in Neurology for MSW trainees, Madurai Institute Medicine Unit, Dept. of Clinical Psychology, NIMHANS of Social Sciences, Tamil Nadu, 23 September 2015 (iv) Trauma
National Institute of Mental Health and Neuro Sciences 311 Annual Report 2015-2016
and Families. National Conference on Trauma: Recovery and Work Methods in Centre for Addiction Medicine, Centre for Growth through Counselling and Psychotherapy, October 2015. Addiction Medicine, NIMHANS, 9 February 2016.
33. Rajeswaran J. Historical development of neuro-biofeedback 36. Shah A. (i) Qualitative methods in psychosocial research. techniques; EEG Neurofeedback training in TBI; EEG neuro National workshop on Statistical Methods in Behavioral feedback training in ADS; EEG neuro feedback training in Research, Department of Biostatistics, NIMHANS, 28-30 ADHD. CRE program on Application of Neuro-Biofeedback September 2015 (ii) Family and marital therapy. Clinical Therapy among patients with Neuro-Psychiatric Conditions, Psychology: Promoting Mental Health, Dept. of Clinical Dept. of Psychology & Mental Health, School of Humanities Psychology, NIMHANS, 5-6 February 2016. & Social Sciences, Rehabilitation Council of India, Gautam Buddha University, Uttar Pradesh, 3-5 March 2016. 37. Shankaranarayana Rao BS. The ethics of scientific research and publication. National Conference on Ethical Issues in Scientific 34. Rajeswari C. (i) Current scenario of maternal health services Writing. Maharani’s Science College for Women, Bengaluru, in India. National Conference on Recent Updates in National 3-4 September 2015. Health Service, Kasturba Gandhi College of Nursing, Puducherry, 30 April 2015 (ii) Lateral incivility. National 38. Sharma MK. (i) Deaddiction & suicide. Oxford College of Arts Conference on Abrogate Incivility in Nursing, College of & Science, Bengaluru, 24 April 2015 (ii) Screening of substance Nursing, MAHER University, Kanchipuram, 7 November use and technology addiction. Substance use training of yuva 2015. parivarthakas, Dept. of Epidemiology, NIMHANS, 6- 10 June 2015 (iii) Research in technology addiction. Deakin University 35. Senu E. (i) The challenges and way forward for inclusion of & Teri Gram Gualpaahari, New Delhi, 6-9 September 2015 persons with disability in inclusion matters (panel discussion). (iv) Cognitive behavior therapy in substance use disorder. One Symposium on Disability and Inclusion, International Day for month orientation program on substance use disorders, Centre Persons with Disabilities, Dept. of Psychiatric Social Work, for Addiction Medicine, NIMHANS, 1-30 November 15 (v) NIMHANS, 3 December 2015 (ii) Human rights education Internet and gaming addiction in adolescent health and well- for social work practice. School of Social Work, Roshini Nilaya, being: Contemporary challenges and emerging role of schools. Mangalore, 4 March 2016 (iii) Brief interventions in tobacco Regional Workshop for the All India Edu-leaders Forum, cessation programme. National Tobacco Control Programme, Ujjain, Madhya Pradesh, 23 January 2016 (vi) Psychological Assam and Bangalore Institute of Dental Science, Centre assessment and addictive behaviours. Clinical psychology: for Addiction Medicine, NIMHANS, 30 October 2015 (iv) Promoting mental health, Dept. of Clinical psychology, Relapse prevention for persons with substance use disorders. NIMHANS, Bengaluru, 5- 6 February 16. National orientation programme on Substance Use Disorders, Centre for Addiction Medicine, NIMHANS, 20 November 39. Shivashankar N. (i) Common speech and hearing problems- 2015 (v) Motivational interviewing for persons with alcohol use Identification and remedial activities. Seminar for teachers, disorder. Current Trends in Psychiatric Social Work Practice, Dept. of Child and Adolescent Psychiatry, NIMHANS, Dept. of Psychiatric Social Work, NIMHANS, 9 December 11 August 2015 (ii) Issues related to balance and hearing in 2015 (vii) International Orientation Programme on Practice patients with TBI. TBI Conference, ISH, Bangalore, 10 of Social Work Methods. Centre for Addiction Medicine, for September 2015 (iii) (a) Electrophysiological assessment of PG Students of Social Work, St. Ambrose University, IOWA, the auditory system-Clinical Perspective. (b) Establishing United States, Centre for Addiction Medicine, NIMHANS, private practice: ethics, documentation, reporting. KSB-ISHA, January 2016 (viii) Brief advice and intervention for persons Waynad, Kerala, 12-13 September 2015 (iv) CAPD-Atypical with alcohol use disorders. Deaddiction Treatment Program case studies. Recent advances in CAPD-AIISH, Mysore, 28 for doctors and counsellors from State Health Society, October 2015 (v) Auditory disorders secondary to neurological Government of Bihar, Centre for Addiction Medicine, lesions. Clinical Update on Neurogenic Communication NIMHANS, 26 February 2016 (ix) Group therapy and relapse Disorders in Adults, Krishna Institute of Medical Sciences, prevention for persons with alcohol use disorders. National Hyderabad, 11 December 2015 (vi) Aphasia-Overview of Deaddiction Treatment Program for doctors and counsellors language disorder and informal assessment. Clinical Update from State Health Society, Government of Bihar, Centre on Neurogenic Communication Disorders in Adults, Krishna for Addiction Medicine, NIMHANS, 27 February 2016 (x) Institute of Medical Sciences, Hyderabad, 11 December 2015 International Orientation Programme for Mental Health Team (vii) Neurological Lesions Affecting CANS - Case Studies. from Monash University, Johor, Malaysia on Practice of Social CEP on Auditory Processing Deficits in Older Adults, 48th
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ISHACON, Mumbai, 4 February 2016 (viii) Neurological 43. Tyagi V. (i) Workshop on Cross- Cultural Issues and the abnormalities of central auditory nervous system and auditory Assessment & Measurement of Quality of life in Mental Illness. processing. National seminar on Neurological Abnormalities of Symposium of Quality of Life in Chronic Mental Illnesses: Central Auditory Nervous System and Auditory Processing, Exploring New Frontiers, NIMHANS, 30 January 2016 (ii) Institute of Speech and Hearing, Madras Medical College and Volunteers Sensitization Programme, NCWB, 1 August 2015. Rajiv Gandhi Govt. General Hospital, Chennai, 4 March 2016 (ix) Lesions of central auditory nervous system and auditory 44. Valliammal S. (i) Developmental concerns in adopted children. processing. Dr. M.V. Setty College of Speech and Hearing, Psychosocial Issues and Role of a Nurse in Child Adoption, Mangalore, 12 March 2016 (x) Differential diagnosis in College of Nursing, NIMHANS, 11 March 2016 (ii) National childhood language disorders - Missing an angle misses the mental health services available at door steps. National path. Seminar on Advances in the Assessment of Childhood conference on Recent Updates in National Health Service, Language Disorders, JSS Institute of Speech and Hearing, Kasturba Gandhi College of Nursing, Puducherry, 30 April Mysore, 21 March 2016. 2015.
40. Sudhir PM. (i) Currents trends in the psychotherapy for 45. Veena Satyanarayanan. (i) Trauma specific guidelines in OCD. CME, 46th Annual conference of the West Zone of CODE: Conforming to directives and ethics. Workshop the Indian Psychiatry. Amby Valley, Pune, Maharashtra, 9-11 on Ethical Issues in Trauma Informed Care, NIMHANS October 2015 (ii) Training in the use of MINI module for Centre for Wellbeing (NCWB), Bengaluru 10 June 2015 OCD and GAD. First National collaborators meeting and (ii) Assessment of marital trauma. HOME: Handling & Masters training program, NIMHANS, 1-6 April 2015 (iii) (a) Overcoming Marital Estrangement- A Workshop on Marital Beliefs assumptions in CBT (b) Cognitive behavioural model Trauma, NCWB, Bengaluru, 1 August 2015 (iii) Assessment of anxiety (c) Cognitive strategies for anxiety. Workshop on of elder abuse, AGED: Acquiring Greater Empowerment and Cognitive Behavioural Therapy: Principles and Applications, Dignity, workshop on Addressing Psychological Trauma Due Dept. of Clinical Psychology, NIMHANS, 9-10 July 2015 to Elder Abuse. Workshop for Counselors in Shelter Homes, (iv) (a) Common myths and misconceptions in sexual NCWB, Bengaluru, 3 October 2015 (iv) Evidence based dysfunctions (b) Cognitive behavioural management of female psychological therapies in the perinatal period in the Perinatal sexual dysfunctions. Workshop on Cognitive Behavioural Psychiatry Series in Virtual Knowledge Network, NIMHANS, Interventions for Sexual Dysfunctions, Dept. of Clinical 16 October 2015 (v) Psychological interventions in pregnancy Psychology, NIMHANS, 7-8 January 2016 (v) Behavioural and postpartum. National Conference on Motherhood and medicine. Orientation to clinical Psychology, Dept. of Clinical Mental Health, NIMHANS, 31 October 2015 (vi) Research Psychology, NIMHANS, 5-6 February 2016. ethics. Workshop on Research Methodology, Departments of Biostatistics, Epidemiology, Psychiatry and Neurology, 41. Suman LN. (i) Crisis situations in academic settings and crisis NIMHANS, 10-12 December 2015 (vii) Assessment of assessment; Counseling skills, ethics and crisis intervention; trauma. PACT: Parent Awareness of Child Trauma, NCWB, Preparedness and prevention of crisis situations. TEACH- Bengaluru, 30 January 2016 (viii) Enabling recovery from Trauma, Emergency and Crises Help- A Workshop on Crisis Trauma. HURT: Home Upbringing for Recovery from Management in Academic Settings, Dept. of Psychology, Trauma, NCWB, Bengaluru, 30 January 2016 (ix) Counselling Prajyoti Niketan College, Pudukad, Thrissur, Kerala, 22 skills and techniques. Counselling Skills for Children, Adults September 2015 (ii) Advance directives and rights of a person and Families, NCWB, Bengaluru, 8-9 February 2016. with mental illness. Workshop on Critique of Mental Health Care Bill, 2013, Department of Nursing, NIMHANS, 15 46. Veena Satyanarayanan, Poornima Mahindru. Mothers with October 2015 (iii) (a) Scope of clinical psychology (b) Substance borderline personality disorders and their infants. National abuse: Services, training and research and introduction to Conference on Motherhood and Mental Health, 31 October, 2015. forensic psychology. Orientation to Clinical Psychology Program for Postgraduate Students in Psychology, Dept. of 47. Vijaya Lakshmi P. Initiative steps in evidenced based practice Clinical Psychology, NIMHANS, 5-6 February 2016. in nursing: An Indian scenario. Transforming Care at Bedside Ameliorates Patient Care and Improves Vitality of Health Care 42. Thirumoorthy A. (i) National Conference on Professionalism Team, College of Nursing, NIMHANS, 11-12 January 2016. in Social Work: Trends and Challenges, 15 September 2015 (ii) International Symposium on Integrating Mental Health Care 48. Vinayak K. Child Psychiatric Disorders- ADHD and other & Non Communicable Disorders, 13-15 November 2015. disruptive behavioral disorders. Regional CME on Pediatric
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Psychopharmacology, Dept. of Pediatrics, MR Medical College, 5. Kulkarni Girish Baburao. Talk on Stroke. Hello Doctor. All Gulbarga, 21 June 2015. India Radio, Bengaluru, 14 December 2015.
49. Vranda MN. (i) Moderated regional session on realities in 6. Manjula M, (i) Celebrating relationships. Janashree TV practice. Symposium on Disability and Inclusion: Inclusion Channel, 8 December 2016 (ii) Cognitive Behaviour Therapy in Matters, NIMHANS, 3 December 2015 (ii) Expressed emotions Mental Illness. Manochintana, FM Radio phone-in-program, and mental, 15 February 2016 (iii) Introduction to Geriatric 28 August 2015. Psychiatry, Dementia and Types and Psychosocial Management with Patients and their Caregivers, 16 February 2016. 7. Manoj Kumar Sharma. (i) Internet addiction among children. News 24, 18 April 2015 (ii) Lust control: How doctors in 50. Yamini BK. (i) Current status of hearing screening with Bengaluru are attempting to help porn-addicts. The News audiometer. Consortium of Development of Audiometric Minute (news portal), 26 August 2015 (iii) Smartphone use Guidelines, Department of Speech and Hearing, SOAHS, and children: Need to bring balance. BBC Radio, 4 March Manipal University, 4-6 December 2015 (ii) Challenges in 2016 the management of individuals with motor speech disorders- My experiences. Pre-conference seminar of 48th National 8. Nagarathna S. (i) Infections of the central nervous system, Convention of Indian Speech and Hearing Association, Radio Doctor, Prasara Bharati All India Radio, 5 January 2016 Mumbai, Maharashtra, 4 February 2016 (iii) Dysphagia (ii) Neurocysticercosis, Radio Doctor, Prasara Bharati, All profiles in adults with neurogenic disorders. 48th National India Radio, 14 January 2016 (iii) Food hygiene, Radio Doctor, Convention of Indian Speech and Hearing Association, Prasara Bharati, All India Radio, 27 January 2016 (iv) Malaria, Mumbai, Maharashtra, 5-7 February 2016. Radio Doctor, Prasara Bharati, All India Radio, 6 February 2016.
Radio/Tv/New Media Programmes 9. Nithya Poornima M, Child Prodigy. Strategy behind a prodigy: Panel discussion. News9, Bengaluru, 20 January 2016. 1. Aarti Jagannathan, (i) Mansik Swasth – Man ki Sehath, awareness talk in Hindi (Mental Health-Health of the Mind), 10. Pradeep BS, Yuva Janarigaagi Yuva Janaru, Yuva Parva (talk in White Swan Foundation, Youtube http://www.youtube.com/ Kannada). Yuva Spandana, All India Radio, January 2016. watch?v=BkakMo-gVs February 2016. 11. Satish Girimaji. Busting exam myths. White Swan Foundation, 2. Gururaj G, Yuva Janarigaagi Yuva Janaru, Yuva Parva (talk in Youtube https://www.youtube.com/watch?v=qxBCuyJvJ4c, 1 Kannada). Yuva Spandana, All India Radio, January 2016. March 2016.
3. Harish T, Postpartum Psychosis, All India Radio, 26 December 12. Sinu E, (i) Assessment of tobacco use. Dhum Idre Dhum Bidi, 2015. E-TV, 31 May 2015 (ii) Dealing with Tobacco withdrawal symptoms. Dhum Idre Dhum Bidi, BIG FM, 30 May 2015. 4. John Vijay Sagar K. (i) Dealing with separation anxiety in young children. I don’t want to go to school today! Website of White 13. Sivakumar PT, Srikala Bharath. Alzheimer’s dementia. Panel Swan Foundation. (http://www.whiteswanfoundation.org/ discussion, Udaya News TV, 18 September 2015. article/sailing-through-separation-anxiety/) (ii) Play therapy can help children explore their emotional issues and cope better 14. Srinivas Bharath MM. Turmeric, pinch of sunshine. ‘Wise healing through play: How does play therapy work? Website of Spice’ documentaries under “Spices of India”, DD National White Swan Foundation. (http://www.whiteswanfoundation. (DD1), Vigyan Prasar, DST, 17 October 2015. org/article/playing-to-heal-how-does-play-therapy-work/)
314 National Institute of Mental Health and Neuro Sciences Public Lectures
Child & Adolescent Psychiatry CME Programme 2015, Visakha Psychiatric Society, Visakhapatnam, Andhra Pradesh, 29 November 2015. Target group: Post-graduate Dr. Shoba Srinath, Sr. Professor, Parental role in early days of students of Psychiatry and Clinical Psychology (ii) Social and schooling, Jyothy Kendriya Vidyalaya, Bengaluru, 30 May 2015. emotional skills for adults with autism, Workshop on Adults With Target group: Parents. Autism, Karnataka Parents Association for Mentally Retarded Citizens, Bengaluru, 19 March 2016. Target group: Mental Health Dr. K John Vijay Sagar, Additional Professor, Life skills and adolescent Counsellors, Psychologists and Parents of Autistic Adults. mental health, Seminar on Life Skills, Bengaluru, 31 January 2016. Target group: Parents, teachers, counselors and students. Dr. Jyotsna Agrawal, Assistant Professor, How to live a happy life, DST-sponsored INSPIRE Science Internship Camp, Christ University, Bengaluru, 30 October 2015. Target group: Pre-university Clinical Psychology students.
Dr. Uma Hirisave, Professor, Dealing with emotional experiences: A Epidemiology group interactive experience, Maruti School, Bengaluru, 15 February 2016. Target group: Schoolchildren Dr. Pradeep BS, Associate Professor, (i) Adolescent health problems: Current situation, CME on Adolescent Health and Tobacco, Kolar, Dr. Keshav Kumar, Additional Professor, Midbrain activation: 14 March 2016. Target group: Doctors and postgraduate students Awareness of false claims, Karnataka Rajya Vijnana Parishat, (ii) HMIS systems for control of NCDs in workplaces, Workshop Bengaluru, 12 May 2015. Target group: General public. on Management of Mental Health, Substance Use Disorders and Non-communicable Diseases in Workplaces, Bengaluru, 10 July Dr. Poornima Bhola, Associate Professor, Women’s mental health 2015. Target group: Industrial medical officers (iii) Good practices/ at work place, Women’s Day programme, Mount Carmel College, guidelines in the preparation of quality research papers, CME on Bengaluru, 24 February, 2016. Target group: Teachers. Research and Publications, MS Ramaiah Medical College, Bengaluru, 4 December 2015. Target group: Dentists and Pharmacists (iv) Risk Dr. M Thomas Kishore, Associate Professor, (i) Assessment and factors for non-communicable diseases, Sensitization Programme in interventions in intellectual and developmental disabilities, Workshop NCDs and MNSUDs for Occupational Health Staff, Narasapura on Intellectual and Developmental Disabilities Rehabilitation, Industrial Region, Kolar, 2-3 December 2015. Target group: Guwahati, Assam, 7- 9 July 2015. Target group: Professionals including Occupational Health Staff. Clinical Psychologists(ii) Psychological assessment and Interventions, Orientation on Clinical Psychology, AIIMS, Rishikesh, Uttarakhand, 6-7 Dr. Gautham MS, Assistant Professor, Changing paradigms in November 2015. Target group: MBBS Students (iii) Secular approaches occupational health stress in workplaces, Workshop for Labour Union to counselling, Advanced Counselling, Hyderabad, Telangana, 24 Leaders, Shri Alampally Chair on Labour Research, Bangalore University, January 2016. Target group: Lay Counsellors (iv) Counselling persons Bengaluru, 3 August 2015. Target group: Labour Union leaders with intellectual disabilities, Training Programme for Counselors and Caregivers, Fame India, Bengaluru, 25 January 2016. Target group: Dr. Arvind BA, Assistant Professor, (i) Screening for substance use Counselors and caregivers of persons with IDD (v) Counseling children (ii) Making sense of health data, Sensitization programme in NCDs and adolescents, Advanced Counselling, Bengaluru, 8-9 February and MNSUDs for Occupational Health staff, Narasapura Industrial 2016. Target group: Lay Counsellors (vi) Specific learning disabilities, Region, Kolar, 2-3 December 2015. Target group: Occupational Rehabilitation Council of India Regional Meet for Capacity Building health staff. of Rehabilitation Professionals, Imphal, Manipur, 4 March 2016. Target group: Rehabilitation Professionals including Clinical Psychologists. Mr. Manjunath, Field Information Officer, Mr. Saijan, Field Information Officer, Awareness on epilepsy and preventing head Dr. Nitin Anand, Assistant Professor, (i) Cognitive behaviour therapy injuries, Joint Activity with the Indian Epilepsy Association, Kolar, 1 for obsessive compulsive disorder, IPS Andhra Pradesh State PG December 2015-8 February 2016. Target group: High-school students.
National Institute of Mental Health and Neuro Sciences 315 Annual Report 2015-2016
Neurology Dr. BS Shankaranarayana Rao, Professor, (i) The ever-changing brain: Rewiring and remodelling of brain circuits, International Institute of Dr. SR Chandra, Professor, Ageing and dementia, World Elders Day Information Technology- Bangalore (IIIT-B), Bengaluru, 24 April 2015. celebration, JP Nagar, Bengaluru, 14 November 2015. Target group: Target group: Faculty, staff and students (ii) The ethics in science and Senior Citizens. publication, Annamalai University, Chidambaram, India, 11 September 2015. Target group: Faculty, staff and students (iii) Moulding your brain Dr. Pramod Kumar Pal, Professor, Dr. Dwarkanath Srinivas, Additional for the better learning and behavior, Brain Awareness and Outreach Professor and Dr. Ravi Yadav, Associate Professor, Parkinson’s disease, Programme, Widia Poorna Prajna School, Bengaluru, 30 January 2016. Parkinson’s Day program, Ashwini Hall, NIMHANS, 11 April 2015. Target group: Teachers and students (iv) The ever-changing brain and Target group: Patients and caregivers new challenges in treating brain disorders including memory deficits, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Dr. Girish Baburao Kulkarni, Additional Professor, Common India, 9 February 2016. Target group: Faculty and students. neurological problems, Monthly Health Topic, Jayanagar Study Circle, Bengaluru, 27 February 2016. Target group: General Public. College of Nursing
Neuromicrobiology Dr. BV Kathyayani, Principal, Mrs. A Shamala, Clinical Instructor, Mrs. Annie P John, Clinical Instructor, Mrs.T.S.Sunitha, Clinical Instructor, Dr. Ravikumar R, Professor, (i) Automation in clinical microbiology, Mrs. N. Padmavathy, Clinical Instructor, Care of elderly and Alzheimer’s, AIPL facilitates microbiologists, Seminar on Microbiology Today, Sri World Elderly and Alzheimer’s Day Exhibition, OPD, NIMHANS, Lanka College of Microbiologists, Sri Lanka, 16 August 2015. Target Bengaluru, 22-30 September 2015. Target group: General public. group: Microbiologists (ii) Brain infection, Unilever, R&D Bengaluru, 8 January 2016. Target group: General Public (iii) Automation in Dr. Priya Baby, Lecturer, Mrs. Annie P John, Clinical Instructor, Mrs. microbiology and newer molecular biology techniques, Karnataka N Padmavathy, Clinical Instructor, Awareness programme (exhibition State Lab Technologists Association, KIMS Hospital, Bengaluru, 14 cum puppet show), World TB day, Victoria Hospital, Bengaluru, 23 February 2016. Target group: Lab Technologists. March 2016. Target group: Patients and relatives visiting OPD.
Dr. Priya Baby, Lecturer, Mrs. N Padmavathy, Clinical Instructor, Neuropathology Exhibition, National Education Day, College of Nursing, NIMHANS, 12 November 2015. Target group: College students. Dr. Shankar SK, Emeritus Professor, Let us join hands for better care, World Alzheimer’s Day, Bengaluru, 26 September 2015. Target Ms. Jeeva S, Lecturer, (i) Intensified pulse polio immunization group: Senior Citizens. programme, National Pulse Polio days, Adugodi, Wilson Garden, Taverekere Health Centre, BBMP-NS Palaya, Vivek Nagar, Neurophysiology Singasandra PHC, Bengaluru, (a) 17-20 January 2016 (b) 21-24 February 2016. Target group: Children below five years of age (ii) Dr. Bindu M Kutty, Professor, (i) The meditative mind: Towards Prevention and control of NCD’s, Mass Health Education- Role understanding cognitive reserve and consciousness, Tibet House, Play, Sarjapur, Bengaluru, 3 December 2015. Target group: General New Delhi, 23-27 October 2015. Target group: General Public (ii) public (iii) Antenatal care, Mass Health Education- Role Play, Vipassana meditation and cognition, Research Council Meeting, Sarjapur, Bengaluru, 3 December 2015. Target group: General public Vipassana Research Institute (VRI), Global Pagoda, Mumbai, 22 (iv) Exhibition, World Cancer Day, Singasandra PHC, Bengaluru, 4 August 2015. Target group: Vipassana Research Scientists and VRI- February 2016. Target group: OPD patients and public (v) Control council members and PIs. and prevention of non-communicable diseases, Mass Health Education–Puppet show, Naganathapura, Bengaluru, 2 March 2016. Dr. TN Sathyaprabha, Professor, (i) Introduction to brain and brain Target group: General public (vi) Assessment of self-care practices of disorder, Outreach Programme, Indian Epilepsy Association, St. diabetic clients, Epidemiological Survey, Naganathapura, Bangalore Claret PU College, Bengaluru, 26 June 2015. Target group: Teachers/ urban, 3 March 2016. Target group: General Public. students of high-school and pre-university (ii) Epilepsy: Myths & misconceptions, Epilepsy Outreach programme, Indian Epilepsy Ms. Jeeva S, Lecturer, Mr. B Jayakumar, Lecturer, Mrs. Bingi Association, St. Joseph’s School, Whitefield, Bengaluru, 17 October Rajeswari, Clinical Instructor, Mr. Rajesh N, Clinical Instructor, 2015. Target group: Teachers, students of high school and their Exhibition, World AIDS Day, Sarjapur PHC, Bengaluru, 1 December parents. 2015. Target group: OPD Patients and public.
316 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Ms. Jeeva S, Lecturer, Mrs. Bingi Rajeswari, Clinical Instructor, Handenahalli village, Bengaluru, 30 January 2016. Target group: (i) Mental Illness, Mass Health Education- Role Play, Sarjapur, General public. Bengaluru, 3 December 2015. Target group: General public (ii) Environmental sanitation, Mass Health Education- Role Play, Mrs. A Shamala, Clinical Instructor, Mrs. Annie P John, Clinical Sarjapur, Bengaluru, 3 December 2015. Target group: General public. Instructor, Healthy living with diabetes, World Diabetes Day Exhibition, Diabetic Clinic, Victoria Hospital, Bengaluru, 14 Ms. Jeeva S, Lecturer, Mr. Rajesh N, Clinical Instructor, (i) Management November 2015. Target group: OPD patients and general public. of under five children, Mass Health Education- Role Play, Sarjapur, Bengaluru, 3 December 2015. Target group: General public (ii) Mrs. A Shamala, Clinical Instructor, Awareness about first aid during Management of problems related to children under five years of age, epilepsy and its management, World Epilepsy Day, Govt. High Mass Health Education- Role Play, Naganathapura, Bengaluru, School, Byrasandra, Bengaluru, 18 November 2015. Target group: 2 March 2016. Target group: General public (iii) Assessment of School students. knowledge of community towards hypertension, Epidemiological Survey, Naganathapura, Bengaluru, 3 March 2016. Target group: General public. Mrs. A Shamala, Clinical Instructor, Mrs. D Mythili, Clinical Instructor, AIDS, World AIDS Day, Victoria Hospital Campus, Ms. Jeeva S, Lecturer, Mrs. Bingi Rajeswari, Clinical Instructor, Mr. Bengaluru, 18 December 2015. Target group: OPD patients and public. Rajesh N, Clinical Instructor, Health assessment and education, School Health Programme, Sarjapur, Bengaluru, 1 December 2015. Target Mrs. Annie P John, Clinical Instructor, Ms. Jeeva S, Lecturer, group: Schoolchildren, GUHPS, JPGS, SMPHP, MPGS. Adult glaucoma screening camp, Screening camp, Naganathapura, Bengaluru, 10 March 2016. Target group: General public. Ms. Jeeva S, Lecturer, Mrs. P Vijayalakshmi, Clinical Instructor, (i) Mental illness and its management, Mass Health Education– Psychiatry MIME, Naganathapura, Bengaluru, 2 March 2016. Target group: General public (ii) Attitude of community towards mentally ill, Dr. Srikala Bharath, Professor, Psychological issues in children with Epidemiological Survey, Naganathapura, Bengaluru, 3 March 2016. cancer, Karunshraya, Bangalore, 23 March 2016. Target Group: Care Target group: General public. providers of children with cancer.
Ms. Jeeva S, Lecturer, Mrs. TS Sunitha, Clinical Instructor, Dr. Prabha S Chandra, Professor, (i) Talk on mental health issues in (i) Promotion of health habits among primary schoolchildren, college students, Faculty Development Program on Teacher Sensitization Epidemiological Survey, Naganathapura, Bengaluru, 3 March 2016. in Counseling, Jain University, Bengaluru, 16 January 2016. Target Target group: General public (ii) Assessment of health status of Group: Faculty (ii) Mental health and motherhood: Issues and concerns, school children, Epidemiological Survey, Naganathapura, Bengaluru, Interactive session with women writers in Kannada, Centre for Public 3 March 2016. Target group: General public. Health, NIMHANS, Bengaluru, 28 July 2015. Target group: Women writers (iii) The adolescent brain, Valley School, Krishnamurthi Mrs. A Shamala, Clinical Instructor, Dr. Pratibha Swamy, Principal, Foundation of India, May 2015. Target Group: Students and parents. Mrs. Kesiya CY, Clinical Instructor, Breast self-examination, World Cancer Day, Gangamma Hombe Gowda Degree College, Wilson Dr. Sivakumar PT, Additional Professor, Talk on awareness about Garden, Bengaluru, 10 February 2016. Target group: College students. mental health problems, Salem, Tamil Nadu, 7 February 2016. Target Group: General public. Mrs. Shamala A, Clinical Instructor, Ms. Jeeva S, Lecturer, Mrs. TS Sunitha, Clinical Instructor, Stroke awareness programme, Stroke and Dr. Santosh Loganathan, Associate Professor, (i) Basic principles of its management, Role Play, Naganathapura, Bengaluru, 29 October family therapy followed by case discussion, Karnataka Mid-term CME 2015. Target group: General public. Program, Karnataka Institute of Medical Sciences, Hubli, 14 June 2015. Target Group: Post-graduate residents in Psychiatry from Karnataka Mrs. A Shamala, Clinical Instructor, Mrs. Annie P John, Clinical (ii) Common mental disorders in work-place settings, Management of Instructor, Mrs. TS Sunitha, Clinical Instructor, Oral Health, Oral Health Mental health, Substance Use Disorders and other Non-Communicable Day Awareness Programme, Govt. Primary & High School, Byrasandra, Diseases in Workplaces, Centre for Public health, Dept. of Epidemiology, Bengaluru, 11 September 2015. Target group: Schoolchildren. NIMHANS, Bengaluru, 7-10 2015. Target Group: Physicians at Workplace (iii) Formative research to devise at street play for mental illness, Mrs. A Shamala, Clinical Instructor, Mrs. TS Sunitha, Clinical Anthroplogical Perspective in Health Care, Arts Theatre, NIMHANS, Instructor, Leprosy: Its recognition and management, Role play, Bengaluru, 23 July 2015. Target Group: Mental health professionals from
National Institute of Mental Health and Neuro Sciences 317 Annual Report 2015-2016 the Humanities (iv) Identification and Management of Common Mental 3 December 2015. Target group: Mental health professionals and Disorders in Workplaces, Pre-conference CME, 68th National conference general public. of Indian Association of Occupational Health, NIMHANS, Bengaluru, 17 February 2016. Target Group: Physicians at workplace (v) Non- Dr. Aarti Jagannathan, Assistant Professor, Managing one’s mental communicable diseases and common mental disorders: Identifying the health, Nightingale’s Elders Enrichment Centre, Malleswaram, link, Annual Day celebrations of CGHS, Indian Medical Association Hall Bengaluru, 15 May 2015. Target group: General public (IMA Hall), 28 February 2016. Target Group: Physicians from CGHS. Psychiatric Social Work Dr. Sinha Preeti, Associate Professor, (i) Sleep- An enigma in elderly, Session on Sleep, Memory and Lifestyle, Kendriya Sadan, Bengaluru, Dr. R. Dhanasekara Pandian, Additional Professor, Addiction Related 22 September 2015. Target Group: CGHS Senior Citizens (ii) Yoga Problems, Awareness Programme on Prevention of Crime, University for healthy aging, commemorating Elder’s day Awareness programme, of Agriculture Sciences, GKVK, Bengaluru, 30 December 2015. Makkala Koota, Bengaluru, 2 October 2015. Target Group: Elderly. Target group: Students of College of Agriculture, GKVK, Bengaluru.
Dr. Dahale Ajit, Assistant Professor, Elderly Mental Health, Alzheimer’s Day programme, Bengaluru, 21-26 September 2015. Dr. Aarti Jagannathan, Assistant Professor, Managing’s One’s Mental Health, Invited Friday Talks, Nightingale’s Elders Enrichment Dr. Hareesh Angothu, Assistant Professor, Sensitization of volunteers Centre, Malleswaram, 15 May 2015. Target group: Elderly. on mental illnesses, NCWB, NIMHANS, Bengaluru, 1 August 2015. Target group: Volunteers including IT professionals. Dr. Sinu E, Assistant Professor, (i) Service Provided by Centre for Addiction Medicine for Persons with Substance Use Disorders, St. Dr. Sundarnag Ganjekar, Assistant Professor, Mental health and John’s Research Institute, Bengaluru, 26 August 2015. Target group: motherhood: Issues and concerns, Interactive session with women Women self-help group members, Soukhya Project (ii) Sensitization writers in Kannada, Centre for Public Health, NIMHANS, on Service Provided by Centre for Addiction Medicine for Persons Bengaluru, 28 July 2015. Target group: Women writers. with Alcohol Use Disorders, Association for Promoting Social Action - APSA, Bengaluru, October 2015. Target group: Women self-help Psychiatric Rehabilitation group members (iii) Awareness Programme on Harmful Effects of Alcohol and Tobacco Use, Govt. Industrial Training Institute Diary Dr. Jagadisha Thirthalli, Professor and I/c Head, (i) Mental illness, Circle, Bengaluru, 17 June 2015. Target group: ITI students. mental retardation: Causes, treatment and rehabilitation, Sensitization Programme for Government Officials of Jagaluru, Davangere, 9-10 Dr. Bino Thomas, Assistant Professor, (i) Problem Solving and Empathy July 2015. Target group: Government officials (ii) Mental illness as Skills for Majors, skill-building programme, Mount Carmel College, cause of disability, workshop as part of the World Disability Day Bengaluru, 30 December 2015. Target group: College students (ii) observation, NIMHANS, 15 December 2015. Target group: District Counseling Skills for Suicide Prevention, Institute of Aerospace Medicine, Disabled Welfare Officers, Karnataka. Bengaluru, 20 January and 16 March 2016. Target group: Trainers and superintendents (iii) Dynamics of Marriage, Pre-marriage Course, St Dr. Krishna Prasad M, Associate Professor, (i) Handling side Thomas Forane Church, Dharmaram, Bengaluru 12 December 2015, 9 effects of medications for mental illnesses, Caregivers’ support and January and 12 March, 2016. Target group: Young adults. education programme, NIMHANS, Bengaluru, 15 September 2015. Target group: Caregivers of persons with mental illness, Psychiatric A Kulandaisamy, Psychiatric Social Worker, Effective Parenting for Rehabilitation Services (ii) Dignity in mental health, World Mental Children with Epilepsy, Community outreach programme, Sagayamery Health Day celebrations, Bhopal, Madhya Pradesh, 10 October 2015. School, Bengaluru, 24 September 2015. Target group: Parents. Target group: General public (iii) Sensitization of Police Control Room personnel, Bengaluru, 16-17 March 2016. Target group: Speech Pathology & Audiology Control Room Police Personnel. Dr. BK Yamini, Assistant Professor, Dr. Pradeep Y, Speech Therapist, Dr. T Sivakumar, Assistant Professor, (i) Sensitization programme Dr. Aravind Kumar R, Speech Therapist, Dr. Meera SS, Speech about mental illness and rehabilitation, Davangere, Karnataka, 9-10 Therapist, Exhibition Display Posters related to speech language July 2015. Target group: Government officials from Davangere District pathology and audiology, Yogakshema - An Event for Senior Citizens, (ii) Needs of persons with psychiatric disorders: Inclusion matters, Bengaluru, 23-24 January 2016. Target group: Senior citizens. Symposium on Disability and Inclusion, NIMHANS, Bengaluru,
318 National Institute of Mental Health and Neuro Sciences Vasudeva Manja A Statutory Bodies
Institute Body
1 Shri. Jagat Prakash Nadda President 11 Chief Secretary Member Hon’ble Union Minister for Government of Karnataka Health and Family Welfare Bengaluru – 560 001 Government of India 12 Prof. K. Vijay Raghavan Member Nirman Bhavan, New Delhi – 110 011 Secretary, Department of Biotechnology 2 Dr. Sharanprakash R. Patil Vice-President Government of India Hon’ble Minister of State for New Delhi – 110 003 Medical Education 13 Dr. V.S. Chauhan Member Government of Karnataka Director, International Centre of Genetic Bengaluru – 560 001 Engineering and Biotechnology 3 Shri. Mallikarjun Kharge Member New Delhi – 110 067 Member of Parliament, Lok Sabha 14 Dr. Vikram Patel Member 4 Shri. P.C. Mohan Member Professor of International Mental Health Member of Parliament, Lok Sabha London School of Hygiene and Tropical Medicine, Sangath Centre, Porvorim 5 Dr. M.V. Rajeev Gowda Member Goa – 403 521 Member of Parliament, Rajya Sabha 15 Dr. Ramesh Budhani Member 6 Secretary (Health) Member Professor of Physics Ministry of Health and Family Welfare Indian Institute of Technology Government of India Kanpur – 208 016 New Delhi – 110 011 16 Justice (Retd.) Prabha Sridevan Member 7 Secretary to Government of India Member No.7, Krishnaswamy Iyer Avenue Department of Expenditure Mylapore, Chennai– 600 004 Ministry of Finance New Delhi – 110 001 17 Shri. Amrit Kumar Bakshy Member President 8 Secretary to Government of India Member Schizophrenia Awareness Association Higher Education Department Pune – 411 041 Ministry of Human Resource Development New Delhi – 110 001 18 Dr. R Thara Member Director 9 Dr. Jagadish Prasad Member Schizophrenia Research Foundation (SCARF) Director General of Health Services Chennai – 600 101 Government of India New Delhi – 110 011 19 Dr. Shoba Srinath Member Sr. Professor of Child and Adolescent 10 Dr. K.S. Ravindranath Member Psychiatry Vice-Chancellor NIMHANS, Bengaluru – 560 029 Rajiv Gandhi University of Health Sciences Bengaluru – 560 041
320 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
20 Dr. S.K. Pandya Member 22 Dr. V Ravi Member Flat 11, 5th Floor, Shanti Kuteer Prof. & Head, Dept. of Neurovirology 215 Netaji Subhash Road Dean (Basic Sciences) Mumbai – 400 020 NIMHANS, Bengaluru – 560 029
21 Dr. Bhabatosh Biswas Member 23 Dr. BN Gangadhar Member Secretary Vice-Chancellor Director The West Bengal University of Health Sciences NIMHANS Kolkata – 700 064 Bengaluru – 560 029
Governing Body
1 Shri. Jagat Prakash Nadda Chairman 8 Dr. R Thara Member Hon’ble Union Minister for Health and Director Family Welfare, Government of India Schizophrenia Research Foundation (SCARF) and President, NIMHANS Chennai – 600 101 Bengaluru – 560 029 9 Prof. Vijay Raghavan Member 2 Shri. PC Mohan Member Secretary, Department of Biotechnology Member of Parliament Ministry of Science and Technology Government of India Government of India New Delhi – 110 011 New Delhi – 110 003
3 Shri. Bhanu Pratap Sharma Member 10 Dr. Bhabatosh Biswas Member Secretary, Dept. of Health and Vice-Chancellor Family Welfare The West Bengal University of Government of India Health Sciences New Delhi – 110 011 Kolkata – 700 064
4 Dr. Jagadish Prasad Member 11 Prof. GN Narayana Reddy Member Director General Health Services Former Director Government of India NIMHANS, Bengaluru – 560 029 New Delhi – 110 011 12 Dr. TR Raju Member 5 Ms. Vijaya Srivastava Member Sr. Professor of Neurophysiology Additional Secretary & Financial Adviser NIMHANS, Bengaluru – 560 029 Ministry of Health and Family Welfare 13 Dr. GS Umamaheswara Rao Member Government of India Sr. Professor of Neuroanaesthesia New Delhi – 110 001 NIMHANS, Bengaluru – 560 029 6 Shri. Arvind Jadhav Member 14 Dr. Shoba Srinath Member Chief Secretary Sr. Professor of Child & Government of Karnataka Adolescent Psychiatry Bengaluru – 560 001 NIMHANS, Bengaluru – 560 029 7 Dr. M Jayaram Member 15 Dr. BN Gangadhar Member Secretary Sr. Professor of Speech Pathology & Director Audiology NIMHANS, Bengaluru – 560 029 Dean (Neurosciences) NIMHANS, Bengaluru – 560 029
National Institute of Mental Health and Neuro Sciences 321 Annual Report 2015-2016
Standing Finance Committee
1 Shri. Bhanu Pratap Sharma Chairman 5 Dr. R Thara Member Secretary Director Ministry of Health & Family Welfare Schizophrenia Research Foundation (SCARF) Government of India, New Delhi–110 001 Chennai – 600 101
2 Dr. Jagadish Prasad Member 6 Dr. Ramesh Budhani Member Director General of Health Services Professor of Physics Government of India, New Delhi – 110 011 Indian Institute of Technology Kanpur – 208016 3 Smt. Vijaya Srivastava Member Additional Secretary & Financial Adviser 7 Dr. V Ravi Member Ministry of Health & Family Welfare Prof. & Head, Dept. of Neurovirology Government of India, New Delhi–110 001 Dean (Basic Sciences) NIMHANS, Bengaluru – 560 029 4 Dr. KS Ravindranath Member Vice-Chancellor 8 Dr. BN Gangadhar Member Secretary Rajiv Gandhi University of Health Sciences Director Bengaluru– 110 041 NIMHANS, Bengaluru – 560 029
Academic Committee
1. Prof. Vijay Raghavan Chairman 7. Dr. Bhabatosh Biswas Member Secretary, Department of Biotechnology Vice-Chancellor Ministry of Science and Technology The West Bengal University of Government of India Health Sciences New Delhi – 110 003 Kolkata –700 064
2. Dr. VS Chauhan Member 8. Prof. Smitha Deshpande Member International Centre for Genetic Head Engineering and Biotechnology Dept. of Psychiatry New Delhi –110 067 Dr. Ram Manohar Lohia Hospital New Delhi– 110 001 3. Dr. KS Ravindranath Member Vice-Chancellor 9. Dr. GS Umamaheswara Rao Member Rajiv Gandhi University of Health Sciences Sr. Professor of Neuroanaesthesia Bengaluru –560 041 NIMHANS, Bengaluru – 560 029
4. Prof. KVR Sastry Member 10. Dr. Shoba Srinath Member Consultant Neurosurgeon Sr. Professor of Child & 3-4-502, Flat 2, Kamal, Barkatpura Adolescent Psychiatry, Hyderabad –500 027 NIMHANS, Bengaluru – 560 029
5. Dr. Padma Srivastava Member 11. Dr. V Ravi Member Professor of Neurology Prof. & Head All India Institute of Medical Sciences Dept. of Neurovirology New Delhi– 110 029 Dean (Basic Sciences) NIMHANS, Bengaluru – 560 029 6. Prof. AV Srinivasan Member Institute of Neurology 12. Dr. BN Gangadhar Member Secretary Madras Medical College Director Chennai– 600 003 NIMHANS, Bengaluru – 560 029
322 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Planning and Monitoring Committee
1 Dr. MV Rajeev Gowda Chairman 5 Prof. Ravikumar TS Member Member of Parliament (Rajya Sabha) 231, B, Kilpauk Garden Road Kilpauk, Chennai – 600 010 2 Dr. SK Pandya Member Flat 11, 5th Floor, Shanti Kuteer 6 Prof. DN Rao Member 215 Netaji Subhash Road, Mumbai – 400 020 Professor, Department of Biochemistry Indian Institute of Science 3 Prof. K Vijay Raghavan Member Bengaluru –560 012 Secretary, Department of Biotechnology Government of India, New Delhi – 110 003 7 Dr. BN Gangadhar Member Secretary Director 4 Dr. Vikram Patel Member NIMHANS, Bengaluru – 560 029 Adjunct Professor Public Health Foundation of India Delhi – 110 016
Standing Estate Committee
1. Justice (Rtd.) Prabha Sridevan Chairperson 5. Dr. Shoba Srinath Member No. 7, Krishnaswamy Iyer Avenue Sr. Professor of Child & Mylapore, Chennai – 600 004 Adolescent Psychiatry NIMHANS, Bengaluru –560 029 2. Dr. KS Ravindranath Member Vice-Chancellor 6. Dr. M Jayaram Member Rajiv Gandhi University of Health Sr. Professor of Speech Pathology & Sciences, Bengaluru –560 041 Audiology Dean (Neurosciences) 3. Dr. CS Viswanatha Member NIMHANS, Bengaluru – 560 029 Retd. Engineer IISc, Bengaluru & Former Chairman 7. Dr. V Bhadrinarayan Member Task Force on Quality Constructions Medical Superintendent Govt. of Karnataka NIMHANS, Bengaluru – 560 029
4. Dr. Bhabatosh Biswas Member 8. Dr. BN Gangadhar Member Secretary Vice-Chancellor Director The West Bengal University of Health NIMHANS, Bengaluru – 560 029 Sciences Kolkata – 700 064
Hospital Management Committee
1 Shri. Amrit Kumar Bakshy Chairman 4 Dr. R Thara Member President Director Schizophrenia Awareness Association Schizophrenia Research Foundation (SCARF) Pune – 411 041 Chennai – 600 101
2 Shri. Mallikarjun Kharge Member 5 Dr. Umamaheswara Rao Member Member of Parliament Sr. Professor of Neuroanaesthesia Government of India, New Delhi – 110 011 NIMHANS, Bengaluru – 560 029
3 Dr. SK Chaturvedi Member 6 Dr. Shoba Srinath Member Professor of Psychiatry and Professor of Child and Dean (Behavioural Sciences) Adolescent Psychiatry NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029
National Institute of Mental Health and Neuro Sciences 323 Annual Report 2015-2016
7 Dr. AB Taly Member 9 Dr. BN Gangadhar Member Secretary Professor of Neurology Director NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029
8 Dr. V Bhadrinarayan Member Medical Superintendent NIMHANS, Bengaluru – 560 029
Board of Studies
Basic Sciences
1 Dr. V Ravi Chairman 5 The Head Member Prof. & Head, Dept. of Neurovirology Department of Biostatistics Dean (Basic Sciences) NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029 6 The Head Member 2 Dr. Sudhir Krishna Member Department of Human Genetics (from 02.02.2015) NIMHANS, Bengaluru – 560 029 Professor, National Centre for 7 The Head Member Biological Sciences Department of Neurochemistry Cell Organization and Signalling Lab NIMHANS, Bengaluru – 560 029 Tata Institute of Fundamental Research GKVK, Bellary Road 8 The Head Member Bengaluru – 560 065. Department of Neuromicrobiology NIMHANS, Bengaluru – 560 029 3 Prof. Hemalatha Balaram Member (from 02.02.2015) 9 The Head Member Associate Professor, Molecular Biology and Department of Neurophysiology Genetics Unit, Jawaharlal Nehru NIMHANS, Bengaluru – 560 029 Centre for Advanced Scientific Research 10 The Head Member Jakkur Post Office Department of Neurovirology Bengaluru – 560 064 NIMHANS, Bengaluru – 560 029
4 The Head Member 11 The Head Member Department of Biophysics Department of Psychopharmacology NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029
Behavioural Sciences
1 Dr. SK Chaturvedi Chairman 3 Dr. Swaminath Gopala Rao Member Professor of Psychiatry and (from 23.01.2015 to 22.01.2018) Dean (Behavioural Sciences) Professor of Psychiatry NIMHANS, Bengaluru – 560 029 #675, 11th Main, 45th Cross 3rd Block, Rajajinagar 2 Dr.Tanya Machado Member Bengaluru – 560 010 (up to 16.08.2015) Professor of Clinical Psychology 4 Dr. Aditya Murthy Member 502, Block I, Ansals Krishna (from 03.02.2016) Hosur Road, Audugodi Professor of Cognitive Sciences Bengaluru – 560 030 Centre for Neuro Sciences, Old TIFR Building, IISc, Bengaluru – 560 012
324 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
5 The Head Member 8 The Head Member Department of Child & Adolescent Department of Nursing Psychiatry NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029 9 The Head Member 6 The Head Member Department of Psychiatric Social Work Department of Clinical Psychology NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029 10 The Head Member 7 The Head Member Department of Psychiatry Department of Health Education NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029
Neuro Sciences
1 Dr. M Jayaram Chairman 7 The Head Member Sr. Professor of Speech Pathology & Department of Neuroanaesthesia Audiology NIMHANS, Bengaluru – 560 029 Dean (Neurosciences) 8 The Head Member NIMHANS, Bengaluru – 560 029 Department of Neurosurgery 2 Dr. Ravi Gopal Varma Member NIMHANS, Bengaluru – 560 029 (up to 16.08.2015) 9 The Head Member Professor of Neurosurgery Department of Neurology Institute of Neuro Sciences, I Floor NIMHANS, Bengaluru – 560 029 M.S.Ramaiah Memorial Hospital Institute of Neuro Sciences, I Floor 10 The Head Member Bengaluru – 560 056 Department of Neuro Imaging & Interventional Radiology 3 Dr. Mathew Alexander Member NIMHANS, Bengaluru – 560 029 (from 03.02.2015) Professor and Head, Neurology Unit 11 The Head Member Christian Medical College Department of Neuropathology Ida Scudder Road, Vellore NIMHANS, Bengaluru – 560 029 Tamil Nadu - 632 004. 12 The Head Member 4 Dr. B.A. Chandramouli Member Department of Neurological Rehabilitation (from 03.02.2016) NIMHANS, Bengaluru – 560 029 Consultant Neurosurgeon 13 The Head Member Vikram Hospital, No. 71/1 Department of Speech Pathology & Millers Road, Opp. St. Anne’s College Audiology Bengaluru – 560 052. NIMHANS, Bengaluru – 560 029
5 The Head Member 14 The Head Member Department of Epidemiology Department of Transfusion Medicine & NIMHANS, Bengaluru – 560 029 Haematology 6 The Head Member NIMHANS, Bengaluru – 560 029 Department of Clinical Neurosciences (Virtual Department) NIMHANS, Bengaluru – 560 029
National Institute of Mental Health and Neuro Sciences 325 Annual Report 2015-2016
Rehabilitation Committee
1 Dr. BN Gangadhar Chairman 11 Ms. Ruma Banerji Member Director Vice Chairperson NIMHANS, Bengaluru – 560 029 SEVA-IN Action 2 Dr. K Sekar Member 36 ST Bed Layout, 1st Main Registrar Koramangala, Bengaluru – 560 039. NIMHANS, Bengaluru – 560 029 12 Mr. Pranesh S. Member 3 Dr. SK Chaturvedi Member Managing Director Professor of Psychiatry and Prism Books Private Limited Dean (Behavioural Sciences) 865,32nd Cross, Banashankari II Stage NIMHANS, Bengaluru – 560 029 Bengaluru -560 070. 4 Dr. Prabha Chandra Member 13 Dr. Mahendra P Sharma Member Head, Department of Psychiatry Head, Department of Clinical NIMHANS, Bengaluru – 560 029 Psychology 5 Dr. Anupam Gupta Member NIMHANS, Bengaluru – 560 029 Head, Department of Neurological 14 Dr. S Sampath Member Rehabilitation Head, Department of Neurosurgery NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029 6 Dr. A Mohan Member 15 Dr. Pramod Kumar Pal Member Professor & Head Head, Department of Neurology Dept. of Genito Urinary Surgery NIMHANS, Bengaluru – 560 029 St. John’s Medical College and Hospital 16 Dr. D. Muralidhar Member Bengaluru – 560 034 Head, Department of Psychiatric Social 7 Dr. Ravishankar Member Work Consultant Orthopedic Surgeon NIMHANS, Bengaluru – 560 029 St. Philomena’s Hospital 17 Dr. N. Shivashankar Member No.1, Campbell Road Head, Department of Speech Pathology Vivek Nagar, Bengaluru – 560 047. & Audiology 8 Dr. S. Kalyanasundaram Member NIMHANS, Bengaluru – 560 029 Consultant Psychiatrist 18 Dr. Ramachandra Member Richmond Fellowship, Head, Department of Nursing “Asha”, No.501, 47th Cross NIMHANS, Bengaluru – 560 029 9th Main, V Block, Jayanagar 19 Mr. Subroto Bagchi Member Bengaluru – 560 041. Chairman and CEO 9 Ms. Suchetha Kulur Member Mindtree Limited “Friends of NIMHANS” Bengaluru – 560 055. 530, 5th Cross, Mahalaxmi Layout 20 Ms. Shanthi Raghavan Member Bengaluru – 560 086. Founder, EnAble India 10 Dr. Kurien Zachariah Member No.12, KHB Colony (Ground Floor) Professor and Head Brahma Kumari’s Road Dept. of Physical Medicine & Koramangala 8th Block Rehabilitation Bengaluru – 560 095 St. Johns Medical College & Hospital 21 Dr. Jagadisha Thirthalli Member Secretary Bengaluru – 560 034. Prof. & Head, Psychiatric Rehabilitation Services NIMHANS, Bengaluru – 560 029
326 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Human Ethics Committee
1 Dr. Anura Vishwanath Kurpad Chairman 7 Dr. Pratima Murthy Member Professor of Physiology (Medical Doctor) Professor of Psychiatry St. John’s Medical College, St. John’s NIMHANS, Bengaluru – 560 029 National Academy of Health Sciences 8 Dr. Pramod Kumar Pal Member John Nagar, Sarjapur Road, Professor of Neurology Bengaluru – 560 034 NIMHANS, Bengaluru – 560 029 2 Dr. Udaykumar Ranga Member (Scientist) 9 Dr. Rita Christopher Member Professor Professor of Neurochemistry HIV-AIDS Laboratory, Molecular Biology NIMHANS, Bengaluru – 560 029 and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research 10 Dr. N. Shivashankar Member Jakkur (PO), Bengaluru – 560 064 Professor of Speech Pathology and Audiology 3 Dr. Denis Xavier Member NIMHANS, Bengaluru – 560 029 Professor of Pharmacology (Pharmacologist) Dept. of Pharmacology, St. John’s Medical 11 Dr. Uma H Member College, John Nagar, Sarjapur Road Professor of Clinical Psychology Bengaluru – 560 034 NIMHANS, Bengaluru – 560 029
4 Dr. Ashok R. Patil Member 12 Dr. M Jayaram Member Professor of Law (Legal Expert) Sr. Professor of Speech Pathology and Chair on Consumer Law & Practice Audiology, and Dean (Neuro Sciences) National Law School of India University NIMHANS, Bengaluru – 560 029 Post Bag No.7201, Nagarbhavi 13 Dr. V Ravi Member Bengaluru – 560 072 Professor of Neurovirology and 5 Dr. Rajaram Subbian Member Dean (Basic Sciences) No.C410, Cassia (Social Scientist) NIMHANS, Bengaluru – 560 029 Brigade Millennium, Bengaluru – 560 078 14 Dr. SK Chaturvedi Member 6 Ms. Ammu Joseph Member Professor of Psychiatry and Independent Journalist and Author (Community Dean (Behavioral Sciences) No.71, S.T. Bed Layout Representative/Lay NIMHANS, Bengaluru – 560 029 Koramangala, Bengaluru – 560 034 Person)
National Institute of Mental Health and Neuro Sciences 327 Annual Report 2015-2016
Animal Ethics Committee
1 Dr. Anita S. Desai Chairperson 6 Dr. MR Gajendragad Nominee Professor of Neurovirology # 288/15, 14th, ‘A’ Cross CPCSEA NIMHANS, Bengaluru – 560 029 Vyalikaval Bengaluru – 560 003 2 Dr. Dhananjaya I Bhat Member Additional Professor of Neurosurgery 7 Dr. S Ramachandra Member NIMHANS, Bengaluru – 560 029 Professor and HOD, Pharmacology Scientist from Government College of Pharmacy outside the 3 Dr. MM Srinivas Bharath Member Subbaiah Circle Institute Additional Professor of Neurochemistry P Kalinga Rao Road NIMHANS, Bengaluru – 560 029 Bengaluru – 560 027 4 Dr. Rajalakshmi Gope Member 8 Mr. DR Prahallada Member Professor and Head of Human Genetics No. 140/1, (2nd Floor) Non-Scientific NIMHANS, Bengaluru – 560 029 Chinmayee Nilaya Socially Aware 5 Dr. J Suresh Chandra Member Secretary National Park Road Sr. Veterinary Officer (on contract) CARF Bannerughatta NIMHANS, Bengaluru – 560 029 Bengaluru – 560 083
PhD Committees
Basic Sciences
1 Dr. Chittaranjan Andrade Chairman 5 The Head Professor and Head of Department of Biostatistics Psychopharmacology NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029 6 The Head Member 2 Dr. MK Mathew Member Department of Human Genetics Professor, Laboratory of Membrane NIMHANS, Bengaluru – 560 029 Biophysics, National Centre for 7 The Head Member Biological Sciences, TIFR Department of Neurochemistry Bellary Road, Bengaluru – 560 065 NIMHANS, Bengaluru – 560 029 3 Dr. Udaykumar Ranga Member 8 The Head Member Professor, HIV-AIDS Laboratory Department of Neuromicrobiology Molecular Biology and Genetics Unit NIMHANS, Bengaluru – 560 029 Jawaharlal Nehru Centre for Advanced Scientific Research 9 The Head Member Jakkur (PO), Bengaluru – 560 064 Department of Neurophysiology NIMHANS, Bengaluru – 560 029 4 The Head Member Department of Biophysics 10 The Head Member NIMHANS, Bengaluru – 560 029 Department of Neurovirology NIMHANS, Bengaluru – 560 029
328 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Behavioural Sciences
1 Dr. SK Chaturvedi Chairman 5 The Head Member Professor of Psychiatry and Department of Clinical Psychology Dean (Behavioural Sciences) NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029 6 The Head Member 2 Dr. RB Galgali Member Department of Health Education Professor, Department of Psychiatry NIMHANS, Bengaluru – 560 029 St. John’s Medical College Hospital 7 The Head Member Sarjapur Road, Bengaluru – 560 034 Department of Nursing 3 Dr. Rameela Shekhar Member NIMHANS, Bengaluru – 560 029 Professor of Medical & Psychiatric Social 8 The Head Member Work and Dean, PG Department Department of Psychiatric Social Work School of Social Work NIMHANS, Bengaluru – 560 029 Roshini Nilaya, Mangalore - 575 002 9 The Head Member 4 The Head Member Department of Psychiatry Department of Child & Adolescent NIMHANS, Bengaluru – 560 029 Psychiatry NIMHANS, Bengaluru – 560 029
Neuro Sciences
1 Prof. M Jayaram Chairman 7 The Head Member Sr. Professor of Speech Pathology & Department of Neuro Imaging & Audiology Interventional Radiology Dean (Neurosciences) NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029 8 The Head Member 2 Dr. V Rajshekhar Member Department of Professor of Neurosurgery Neurological Rehabilitation and Head, Neurosurgery Unit II NIMHANS, Bengaluru – 560 029 Department of Neurological Sciences 9 The Head Member Christian Medical College Department of Neurology IDA Scudder Road, Vellore – 632 004 NIMHANS, Bengaluru – 560 029 3 Dr A.K. Meena Member 10 The Head Member Professor of Neurology Department of Neuropathology Nizam’s Institute of Medical Sciences (NIMS) NIMHANS, Bengaluru – 560 029 Panjagutta, Hyderabad - 500 082 11 The Head Member 4 The Head Member Department of Neurosurgery Department of Clinical Neurosciences NIMHANS, Bengaluru – 560 029 (Virtual Department) NIMHANS, Bengaluru – 560 029 12 The Head Member Department of Speech Pathology & 5 The Head Member Audiology Department of Epidemiology NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029 13 The Head Member 6 The Head Member Department of Transfusion Medicine and Department of Neuroanaesthesia Haematology NIMHANS, Bengaluru – 560 029 NIMHANS, Bengaluru – 560 029
National Institute of Mental Health and Neuro Sciences 329 Dr. K. S. Meena Faculty and Staff
Dean
Dr. M. Jayaram Sr. Professor of Speech Pathology and Audiology and Dean, Neurosciences Dr. B.N. Gangadhar Professor of Psychiatry and Dean, Behavioural Sciences (till 12.1.2016) Dr. S.K. Chaturvedi Professor of Psychiatry and Dean, Behavioural Sciences (w.e.f. 13.1.2016) Dr. V. Ravi Professor of Neurovirology and Dean, Basic Sciences
Biophysics
Dr. Preeti G. Joshi Professor & Head Dr. Vijay Kumar Kalia Professor (Retired on 30.11.2015) Dr. Balasundaram Padmanabhan Additional Professor Dr. Indrani Datta Assistant Professor Dr. Bhupesh Mehta Assistant Professor
Biostatistics
Dr. K. Thennarasu Professor & Head Dr. D.K. Subbakrishna Professor (Retired on 31.08.2015) Dr. P. Marimuthu Additional Professor Dr. Mariyamma Philip Assistant Professor Dr. Binukumar B Assistant Professor
Child & Adolescent Psychiatry
Dr. Satish Chandra Girimaji Professor & Head Dr. Shoba Srinath Sr. Professor Dr. Shekar P. Seshadri Professor Dr. K. John Vijay Sagar Additional Professor Dr. Preeti Jacob Assistant Professor
Clinical Neurosciences (Virtual Department)
Dr. John P. John Professor of Psychiatry and Head of Clinical Neurosciences Dr. M.M. Srinivas Bharath Additional Professor of Neurochemistry Dr. Arivazhagan A. Additional Professor of Neurosurgery
Clinical Psychology
Dr. Mahendar Prakash Sharma Professor & Head Dr. Ahalya Raguram Professor Dr. H. Uma Professor
National Institute of Mental Health and Neuro Sciences 331 Annual Report 2015-2016
Dr. Anisha Shah Professor Dr. L.N. Suman Professor Dr. Seema Mehrotra Professor Dr. Jamuna Rajeshwaran Additional Professor Dr. Paulomi Matam Sudhir Additional Professor Dr. J. Keshav Kumar Additional Professor Dr. Manoj Kr. Sharma Additional Professor Dr. M. Manjula Additional Professor Dr. Devvarta Kumar Additional Professor Dr. Poornima Bhola Associate Professor Dr. Thomas Kishore M. Associate Professor Dr. B.N. Roopesh Associate Professor Dr. Shantala Hegde Assistant Professor Dr. Veena A. Sathyanarayana Assistant Professor Dr. Aruna Rose Mary Kapanee Assistant Professor Dr. Nitin Anand Assistant Professor Dr. Rajakumari P. Reddy Assistant Professor Dr. Nithya Poornima M. Assistant Professor Dr. Gitanjali Narayanan Assistant Professor Dr. Jyotsna Agrawal Assistant Professor
Epidemiology
Dr. G. Gururaj Sr. Professor & Head Dr. N. Girish Additional Professor Dr. Pradeep B.S. Associate Professor Dr. Gautham M.S. Assistant Professor Dr. Senthil Amudhan R. Assistant Professor Dr. B.A. Aravind Assistant Professor
Human Genetics
Dr. Rajalakshmi Gope Professor & Head Dr. G.K. Chetan Additional Professor Dr. Monojit Debnath Assistant Professor
Mental Health Education
Dr. Jayashree Ramakrishna Professor & Head (Expired on 27-09-2015) Dr. S.K. Chaturvedi Professor of Psychiatry & I/c Head Dr. K.S. Meena Assistant Professor
Neuroanaesthesia
Dr. K.R. Madhusudan Reddy Professor & Head Dr. G.S. Umamaheswara Rao Sr. Professor Dr. V.J. Ramesh Professor Dr. V. Bhadrinarayan Professor Dr. M. Radhakrishnan Additional Professor Dr. K. Sriganesh Associate Professor
332 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Dr. Sudhir V. Assistant Professor Dr. Gopala Krishna K.N. Assistant Professor Dr. Sonia Bansal Assistant Professor Dr. Rohini M. Surve Assistant Professor of Critical Care
Neurochemistry
Dr. Rita Christopher Professor & Head Dr. Sarada Subramanian Additional Professor Dr. M.M. Srinivas Bharath Additional Professor Dr. Nandakumar D.N. Additional Professor Dr. Kruthika Vinod T.P. Sr. Scientific Officer
Neuro Imaging & Interventional Radiology
Dr. Arun Kumar Gupta Professor & Head Dr. Rose Dawn Bharath Additional Professor Dr. Hima Shriniwas Pendharkar Associate Professor Dr. Arvinda H.R. Associate Professor Dr. Jitender Saini Associate Professor Dr. Chandrajit Prasad Associate Professor Dr. Maya Dattatraya Bhat Associate Professor Dr. M. Sandhya Assistant Professor Dr. Chandana Assistant Professor (Nuclear Medicine)
Neurological Rehabilitation
Dr. Arun Kumar B. Taly Professor of Neurology & I/C Head Dr. Anupam Gupta Additional Professor Dr. Meeka Khanna Assistant Professor
Neurology
Dr. P. Satishchandra Sr. Professor & Director/ Vice-Chancellor (till 12.01.2016) Dr. A. Nalini Professor & Head Dr. Arun Kumar B. Taly Professor Dr. M. Veerendra Kumar Professor Dr. S.R. Chandra Professor Dr. Pramod Kumar Pal Professor Dr. Sanjib Sinha Professor Dr. Suvarna Alladi Professor Dr. P. S. Bindu Additional Professor Dr. P.S. Mathuranath Additional Professor Dr. Girish Baburao Kulkarni Additional Professor Dr. Ravi Yadav Associate Professor Dr. Netravathi M. Associate Professor Dr. Subasree R. Assistant Professor Dr. Madhu N. Assistant Professor Dr. Ravindranadh Chowdary Assistant Professor Dr. Pooja M. Assistant Professor
National Institute of Mental Health and Neuro Sciences 333 Annual Report 2015-2016
Neuromicrobiology
Dr. R. Ravikumar Professor & Head (till 09.07.2015) Dr. Shripad A. Patil Professor & Head (w.e.f.10.07.2015) Dr. S. Nagarathna Professor Dr. H.B. Veena Kumari Additional Professor
Neuropathology
Dr. S. K. Shankar Emeritus Professor Dr. T.C.Yasha Professor & Head (till 31.08.2015) Dr. Vani Santosh Professor & Head (w.e.f. 01.09.2015) Dr. N. Gayathri Professor Dr. Anita Mahadevan Additional Professor Dr. B.K. Chandrasekhar Sagar Additional Professor Dr. Nandeesh B.N. Assistant Professor
Neurophysiology
Dr. T.R. Raju Sr. Professor & Head Dr. Bindu M. Kutty Professor Dr. T.N. Sathyaprabha Professor Dr. B.S. Shankaranarayana Rao Professor Dr. Laxmi T. Rao Additional Professor Dr. Vijayalakshmi K. Assistant Professor Dr. Srikumar B.N. Assistant Professor Dr. Phalguni Anand Alladi Sr. Scientific Officer
Neurosurgery
Dr. Malla Bhaskara Rao Professor & Head (till 20.07.2015 Dr. S. Sampath Professor & Head (w.e.f. 21.07.2015) Dr. B. Indira Devi Professor Dr. Dhananjaya I Bhat Additional Professor Dr. Dwarakanath Srinivas Additional Professor Dr. Dhaval P. Shukla Additional Professor Dr. A. Arivazhagan Additional Professor Dr. Nupur Pruthi Additional Professor Dr. KVL Narasinga Rao Additional Professor Dr. V. Vikas Associate Professor Dr. A.R. Prabu Raj Assistant Professor Dr. Amey Rajan Savardekar Assistant Professor Dr. Manjul Tripathi Assistant Professor (Resigned on 16.11.2015) Dr. Nishanth Sadashiva Assistant Professor Dr. Manish Beniwal Assistant Professor Sri. N. Ponnuswamy Sr. Scientific Officer (Radiation Safety)
334 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Neurovirology
Dr. V. Ravi Professor & Head Dr. S.N. Madhusudana Professor (Expired on 02.12.2015) Dr. Anita S. Desai Professor Dr. Reeta Subramaniam Mani Associate Professor Dr. Manjunatha M.V. Sr. Scientific Officer (on contract)
Nursing
Dr. Ramachandra Additional Professor & Head Dr. K. Lalitha Professor Dr. Sailaxmi Gandhi Associate Professor Dr. Prasanthi Nattala Associate Professor Dr. G. Radhakrishnan Assistant Professor
College of Nursing
Dr. B.V. Kathyayani Professor & Principal Dr. Pratibha Swamy Associate Professor Ms. Jayanthi K.N. Lecturer Mr. Jayakumar B. Lecturer Mrs. Poornima H.N. Lecturer Mrs. Priya Baby Lecturer Mrs. D. Kanitha Lecturer Dr. S. Valliammal Lecturer Dr. Rajeswari C. Lecturer Ms. Jeeva S. Lecturer
Psychiatry
Dr. B.N. Gangadhar Professor & Director Dr. Mathew Varghese Professor & Head Dr. Ravi Shankar Pandey Professor (VRS on 30.4.2015) Dr. S.K. Chaturvedi Professor Dr. Sanjeev Jain Professor Dr. Prabha S. Chandra Professor Dr. Pratima Murthy Professor Dr. Srikala Bharath Professor Dr. Y.C. Janardhana Reddy Professor Dr. Vivek Benegal Professor Dr. Jagadisha Thirthalli Professor Dr. John P. John Professor Dr. Suresh Bade Math Additional Professor Dr. G. Venkatasubramanian Additional Professor Dr. P.T. Sivakumar Additional Professor Dr. Geetha Desai Additional Professor Dr. Shivarama Varambally Additional Professor Dr. Prabhat Kumar Chand Additional Professor
National Institute of Mental Health and Neuro Sciences 335 Annual Report 2015-2016
Dr. K. Muralidharan Additional Professor Dr. T. Harish Additional Professor Dr. Santosh Loganathan Associate Professor Dr. V. Senthil Kumar Reddi Associate Professor Dr. C. Naveen Kumar Associate Professor Dr. Shyam Sundar A. Associate Professor Dr. Preeti Sinha Associate Professor Dr. Naren P. Associate Professor Dr. Jaisoorya T.S. Associate Professor Dr. Krishna Prasad M. Associate Professor Dr. Arun K. Assistant Professor Dr. T. Sivakumar Assistant Professor Dr. Sydney Moirangthem Assistant Professor Dr. N. Manjunatha Assistant Professor Dr. Janardhanan C.N. Assistant Professor Dr. Biju Viswanath Assistant Professor Dr. Urvaksh Meherwan Mehta Assistant Professor Dr. Sundarnag Ganjekar Assistant Professor Dr. Angothu Hareesh Assistant Professor Dr. Deepak Jayarajan Assistant Professor Dr. Dahale Ajit Bhalchandra Assistant Professor Dr. Sabina Rao Psychiatrist (Special Grade) (Resigned on 30.09.2015) Dr. Shashidhara H.N. Psychiatrist (Specialist Grade) Dr. Ramakrishnan Kannan Assistant Professor (DST)
Psychiatric Rehabilitation
Dr. Jagadisha Thirthalli Professor & I/c Head of Psychiatric Rehabilitation Dr. S.K. Chaturvedi Professor of Psychiatry Dr. Devvarta Kumar Additional Professor of Clinical Psychology Dr. Poornima Bhola Associate Professor of Clinical Psychology Dr. C. Naveen Kumar Associate Professor of Psychiatry Dr. Krishna Prasad M. Associate Professor of Psychiatry Dr. Sivakumar T. Assistant Professor of Psychiatry Dr. Radhakrishnan G. Assistant Professor of Nursing Dr. Aarti Jagannathan Assistant Professor of Psychiatric Social work, Dr. Hareesh Angothu Assistant Professor of Psychiatry Dr. Deepak Jayarajan Assistant Professor of Psychiatry
Psychiatric Social Work
Dr. K. Sekar Professor & Head Dr. R. Parthasarathy Sr. Professor (Retired on 30.09.2015) Dr. D. Muralidhar Professor Dr. N. Krishna Reddy Additional Professor Dr. R. Dhanasekara Pandian Additional Professor Dr. A. Thirumoorthy Additional Professor Dr. Mohammed Ameer Hamza Additional Professor Dr. B.P. Nirmala Additional Professor
336 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Dr. N. Janardhana Associate Professor Dr. Vranda M.N. Assistant Professor Dr. Gobinda Majhi Assistant Professor Dr. Kavitha V. Jangam Assistant Professor Dr. E. Aravind Raj Assistant Professor Dr. Priya Treesa Thomas Assistant Professor Dr. Aarti Jagannathan Assistant Professor Dr. E. Sinu Assistant Professor Dr. C. Jayakumar Assistant Professor Dr. Bino Thomas Assistant Professor
Psychopharmacology
Dr. Chittaranjan Andrade Professor & Head Dr. N. Pradhan Sr. Professor (Retired on 31.07.2015)
Speech Pathology & Audiology
Dr. N. Shivashankar Professor & Head Dr. M. Jayaram Sr. Professor Dr. Vandana V.P. Assistant Professor Dr. B.K. Yamini Assistant Professor
Transfusion Medicine & Haematology
Dr. Sundar Periyavan Professor and Head (w.e.f. 01.09.2015) Dr. Sangeetha Seshagiri K. Sr. Clinical Pathologist
Ayurvedic Research Unit
Dr. D. Sudhakar Assistant Director Dr. G.Venkateswaralu Research Officer Dr. Hemanth Kumar Gupta Research Officer Dr. Srinibash Sahoo Research Officer Dr. G.V. Ramana Research Officer
Biomedical Engineering Section
Smt. M.G. Sindu Biomedical Engineer Sri. J. Nataraja Sr. Scientific Assistant, Biomedical Engineer, Gr, II Sri. S.N. Jein Sr. Scientific Assistant, Biomedical Engineer, Gr. II Sri. Elangovan Hardware & Network Engineer
Central Animal Research Facility
Dr. J. Sureshchandra Sr. Veterinary Officer (on contract)
National Institute of Mental Health and Neuro Sciences 337 Annual Report 2015-2016
Library & Information Services
Dr. Jayaram M. Sr. Professor of Speech Pathology and Audiology & Officer I/c Smt. Lalitha Koti Sr. Librarian Sri. P. Sulochanan Librarian Sri. Prasad N.N. Librarian Sri. C. Kiran Kumar Librarian (Adhoc)
Publication Department
Sri. Prabhu Dev M. Assistant Editor Smt. Tejaswini A. Proof Reader
Public Relations
Sri. Praseed Kumar Public Relations Officer Sri. A.S. Revappa Assistant Horticulture Officer
Legal Section
Sri. P. Karunakara Gandhi Legal Assistant (on Deputation)
Engineering Department
Sri. N.L. Satish AEE and Head (on Deputation) Sri B.T. Sridhar Assistant Engineer (Civil) Sri. N.R. Nagaraju Assistant Engineer (Civil) (on Deputation) Shri Basavaraj Khelagi Assistant Engineer (Civil) (on Deputation) Shri K.C. Santhosh Assistant Engineer (Civil) (on Deputation) Sri. Prakash C. Kakkayanawar Junior Engineer (Electrical) Sri. H.N. Vittal Rao Junior Engineer (Electrical)
Administration
Dr. V. Ravi Registrar (till 28.07.2015) Dr. K. Sekar Registrar (w.e.f. 29.07.2015) Sri. R. Thimothy Raj Dy. FA & CAO (on deputation) Sri. D. Rajendran Administrative Officer (Retired on 30.04.2015) Sri. M.N. Shankarsa Administrative Officer Sri Venkatesh S. Special Officer (Purchase) Smt. Umavathy AAO (Purchase) Sri. Parameshwara. M. AAO (Personnel) Sri. D.M. Prasad AAO (Co-ordination) Sri. R. Ashwath Narayana AAO (Project) Sri. T. Ravi AAO (Claims) Smt. Ravathi. B.K. AAO (Academic and Evaluation) Sri. Prabhakhar K. AAO (Accounts) Sri. B.G. Balarama Accounts Officer (on deputation) Sri. G.S. Harish Accounts Officer (on deputation)
338 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
Hospital Administration
Dr. V.L. Sateesh Medical Superintendent (Retired on 30.04.2015) Dr. V. Bhadrinarayan Medical Superintendent I/c Dr. V.S. Chandrashekar Resident Medical Officer (on contract) Smt. T. Chandramathi AAO (Hospital Staff Section) Sri. Thanappa AAO (RS) Sri. L.H.B. Boregowda Medical Records Officer Sri. M.L. Laxman Rao Jr. Medical Records Officer Smt. Premalatha Jr. Medical Records Officer Dr. M.R. Mohan Kumar Sr. GDMO Dr. T.N. Prathiba Sr. GDMO Dr. A.S.V.L.N. Ravindra Sr. GDMO
National Institute of Mental Health and Neuro Sciences 339 Jasmine Mary John Annual Report 2015-2016 Finance and Accounts
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Balance Sheet as at 31st March 2016
(Rs. In Lakh) CORPUS / CAPITAL FUND & LIABILITIES SCHEDULE 2015-16 2014-15
CAPITAL FUND 1 36,552.35 28,475.80
ASSET RESERVE-PROJECTS 5 3,051.93 2,800.19
PROJECTS, SEMINARS, WORKSHOPS, ETC., 2 2,997.92 1,248.87
EARMARKED / ENDOWMENT FUNDS 3 47,884.24 44,131.89
CURRENT LIABILITIES AND PROVISIONS 4 4,154.94 3,197.21
TOTAL 94,641.38 79,853.96
ASSETS
FIXED ASSETS 5 38,326.19 28,009.89
INVESTMENTS - FROM EARMARKED / ENDOWMENT FUNDS 6 26,022.60 20,086.28
INVESTMENT - OTHERS 7 10,442.19 13,744.66
CURRENT ASSETS, LOANS, ADVANCES ETC., 8 19,850.40 18,013.13
TOTAL 94,641.38 79,853.96 SIGNIFICANT ACCOUNTING POLICIES 17
NOTES ON ACCOUNTS 18
-Sd- -Sd- -Sd- Deputy Financial Advisor & REGISTRAR DIRECTOR Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 341 Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Income & Expenditure Account for the Year Ended 31st March 2016
(Rs. In Lakh) PARTICULARS SCHEDULE 2015-16 2014-15
INCOME
Income from Services 9 3,036.02 2,603.23
Grants / Subsidies 10 26,833.12 23,753.60
Fees / Subscriptions 11 685.60 370.90
Income From Government Securities/ Bonds 12 - -
Income from Investments 13 1,635.83 1,743.18
Other Income 14 873.22 880.78 TOTAL (A) 33,063.79 29,351.69
EXPENDITURE
Establishment Expenses 15 16,422.22 28,573.54
Other Administrative Expenses etc., 16 11,827.35 6,426.79
Depreciation 5 4,737.67 3,436.98
Prior Period Depreciation 5 - 530.67 TOTAL (B) 32,987.24 38,967.98 Balance being excess of Income over Expenditure (A-B) (figuers in brackets indicate excess of expenditure over income) Transfer to Capital Account 76.55 (9,616.29) TOTAL 33,063.79 29,351.69
SIGNIFICANT ACCOUNTING POLICIES 17 … …
NOTES ON ACCOUNTS 18 … …
-Sd- -Sd- -Sd- Deputy Financial Advisor & REGISTRAR DIRECTOR Chief Accounts Officer
342 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
61.07 (Rs. in Lakh) (Rs.
5.74 1.54 100.42 5,268.85 4,283.05 1,929.92 1,863.98 8,017.61 6,631.63 1,919.53 2,506.81 2015-16 2014-15 16,788.48 14,411.24 20,605.80 16,360.94 10,506.35 10,934.49 34,234.50 42,127.27 engaluru 2015-16 AYMENTS P e on Capital Work-in-Progress Capital e on ear Y nals Data Base Access
rojects - Grants for Projects / Seminars - Grants for Projects rojects ut of own funds - Shortut of own term investment ut of earmarked / endowment funds / endowment ut of earmarked dministrative Expenses dvances to suppliers C Margin Money including opening urchase of Fixedurchase Assets t he
ymposiums / Workshops etc., Workshops ymposiums / Expenses made against funds for variousPayments projects Investments and Deposits made Expenditure on FixedWork- Assets & Capital in-Progress Aided P / a) Establishment Expenses a) O a) P S in Banks b) A b) O b) Expenditur charges c) L c) A d) E-Jour for
I.
II. IV. III.
t s
40.00 m en ay P nd -
A 3.82 14.07 650.00 863.00 400.00 400.00 t s 2,657.69 2,807.95 3,763.70 2,215.85 5,100.00 5,100.00 2015-16 2014-15 14,000.00 14,322.00 13,623.37 12,017.00 eceip R ECEIPTS R NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, B SCIENCES, & NEURO HEALTH INSTITUTE OF MENTAL NATIONAL mposium / workshops, etc mposium / workshops, rojects - Grants for Projects rojects ddiction Centre ddiction ther Grants on-Plan on-Plan rom Staterom Govt. rom Govt. of India Govt. rom rom Other Sourcesrom lan lan avings Accounts Opening Balances Grants Received a) Cash in hand iii) De-A
a) F b) Bank Balances c) F i) P ii) N
-S b) F i) Aided P i) P ii) N seminars / sy ii) O
I. II.
National Institute of Mental Health and Neuro Sciences 343 Annual Report 2015-2016 -
3.87 3.82 21.09 18.45 17.01 48.35 48.82 53.44 560.66 385.70 446.59 882.98 524.33 2,501.38 1,720.94 1,590.60 2,657.69 1,05,389.31 1,04,655.63 ECTOR -Sd- avings accounts OTAL DIR T yments wment Funds me Tax Deductions Tax me oup Insurance Settlement payments ther advances MD/CMD/SD payments ) New Contributory Pension Fund/GPF ) New Contributory Pension Other Payments Closing Balances c) O
a) Endo a) Cash in hand d) Inco
b) GPF funds pa b) Bank Balances in S e) Gr
f
g) E
VI.
VII. -
-Sd- 5.49 20.92 9.01 2.18 5.57 4.00 1.95 7.46 9.67 14.74 0.58 0.48 1.49 3.76 13.79 EGISTRAR 35.73 83.31 30.48 25.60 15.05 11.30 11.75 52.40 45.18 35.59 R 668.55 754.25 268.80 844.80 498.63 401.30 1,904.48 2,165.59 1,104.56 639.69 2,895.98 2,364.83 2,445.08 5,348.83 52,611.97 52,209.77 1,05,389.31 1,04,655.63
OTAL T
-Sd- ccounts Officer y Financial & Advisor ees laneous Receipts al Donations Chief A vestments] est receviables Deput oup Insurance Settlement receipts nvention Centre Advances and Income Advances Centre nvention 185.82 9.68 ruits sales and Nuts ther Recoveries vestments uest house marked / Endowment Funds including Funds / Endowment marked 1,070.71 1,502.24 C Margin money receipts ale of Publications and Tender forms Tender ale of Publications and MD/CMD/SD receipts undry Debtors and Income Tax refundsTax undry Debtors and Income 1,361.45 362.00 oga Centre Water & Electricity Charges Water ) Fees receipts ) GPF Fund Income on Investments from [Ear other in Received Interest Other Income OtherAny Receipts On Bank Deposits h) a) Hospital Receipts a) Inter i) License F b) Gener b) S j) NHS c) Miscel c) In k) DP & NR d) Y d) L l) Co e) G e) E m) F f f n) S g) Hostel Rent g) Gr
h) O
V.
V. I VI. III.
344 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedule Forming Part of Balance Sheet as at 31st March 2016
SCHEDULE - 1 - CORPUS / CAPITAL FUND
(Rs. In Lakh) PARTICULARS 2015-16 2014-15
Balance as at the beginning of the year 28,475.80 28,964.09 Add: Plan Capital Grants received during the year 7,900.00 8,795.00 Add: Capital Grants De-Addiction centre received during the year 100.00 293.00 Add: Other Capital Grants - 40.00 36,475.80 38,092.09 Less: Balance of net expenditure transferred from the Income and Expenditure Account 76.55 (9,616.29) TOTAL 36,552.35 28,475.80
GRANTS FOR PROJECTS / SEMINARS / SYMPOSIUMS / WORKSHOPS / CSIR FELLOWSHIPS FOR THE YEAR 2015-16
SCHEDULE - 2 (Rs. In Lakh) PARTICULARS 2015-16 2014-15 Balance of grants brought forward from previous year 1,248.87 870.18 Grants received during the year 4,076.18 1,893.82 TOTAL 5,325.05 2,764.00 Less: Expenditure incurred during the year (2,439.12) (1,448.74) Add: Project Payables/ (receivables) 111.99 (66.39) TOTAL 2,997.92 1,248.87
-Sd- Deputy Financial Advisor & Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 345 Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedule Forming Part of Balance Sheet as at 31St March 2016
SCHEDULE - 3 - EARMARKED / ENDOWMENT FUNDS
(Rs. In Lakh) PARTICULARS 2015-16 2014-15 a) Opening Balance of the Funds 44,131.89 29,962.61 b) Additions to the Funds: i) Donations / Grants 4,598.13 14,570.12 ii) Income from Investments made on account of funds 2,076.09 1,710.04 iii) Other additions - 6,674.22 - 16,280.16 Total (a+b) 50,806.11 46,242.77 c) Utilisation / Expenditure towards objectives of funds i) Capital Expenditure - - ii) Revenue Expenditure 2,921.87 2,921.87 2,110.88 2,110.88 NET BALANCE AS AT THE YEAR END 47,884.24 44,131.89 Note: Interest income does not include interest from SB Accounts.
-Sd- Deputy Financial Advisor & Chief Accounts Officer
346 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016 - 791 3,500 34,160 7,51,030 5,00,000 7,21,641 1,35,913 4,15,953 2,56,317 1,41,737 2,81,547 1,84,928 3,04,003 7,40,324 2,74,075 60,24,562 16,19,653 10,82,922 31-03-2016 (Figures in Rs.) Balance as on 1,09,97,01,170 ------5,619 7,39,371 1,781 3,32,16,829 2016 791 engaluru 3,500 7,44,990 5,00,000 7,21,641 1,41,737 2,81,547 3,04,003 3,08,872 3,08,872 Total Total Payments 58,04,913 81,41,095 (23,36,182) 32,21,495 66,305 31,55,190 arch 41,40,07,927 3,56,66,838 37,83,41,089 M t FUNDS S ------T 807 34,160 31 6,317 2,56,317 t 39,899 7,51,030 10,086 1,35,913 29,589 10,82,922 29,189 4,15,953 12,885 1,84,928 24,219 7,40,324 22,370 2,74,075 EN a 1,96,509 60,24,562
26,46,151 3,32,18,610 47,10,375 47,10,375 3,52,742 43,57,633 M as
t ------Receipts hee 6,000 83,042 16,19,653 8,250 31,56,825 3,76,18,254 18,60,537 3,57,57,717 ENDOW S / 2,50,000 32,21,495 Grants/ Donations Interest alance - - - ARKED 791 B M 3,500 33,353 7,11,131 7,33,990 11,000 8,04,913 50,00,000 3,88,994 1,25,826 3,32,647 3,86,764 1,41,737 2,81,547 1,72,043 3,04,003 7,16,105 2,51,706 3,08,872 of
58,28,053 15,30,611 19,95,942 2,75,000 1,18,848 23,89,790 2,50,000 21,39,790 10,53,333 3,05,72,459 3,44,53,178 t EAR 01-04-2015 65,18,62,702 40,00,00,000 4,78,38,468 1,09,97,01,170 37,78,04,229 3,62,03,698 Balance as on 1,11,09,65,782 44,53,08,090 5,89,25,580 1,61,51,99,452 4,66,53,789 1,56,85,45,663 ar P - 3 or m ing F SCHEDULE chedule S PARTICULARS NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, B SCIENCES, & NEURO HEALTH INSTITUTE OF MENTAL NATIONAL Bharani Jaya Vijayam Fund Bharani Jaya Endowment Research (DP&NR) Corpus Fund Works for Development Corpus Fund - Projects Corpus Fund Research Brain Fund Cancer Research VishalakshmammaV SchizophreniaFund Research C Endowment Unit Child Psychiatry 5,00,000 Operationof DualCorpusFundfor Ph.D Programme Department of MH & SP Corpus Fund C.M’s Relief Fund C.M’s Department - Corpus of Psychiatry Fund Thirt) & C.F(Turuvekere Dept of Psychiatry Fund Memorial Award Vasanth Anisya Dr. Dr. D.N. Prasad M.F. - Cognition and Music - Cognition M.F. Prasad D.N. Dr. Dr. R.N. Murthy Endowment Fund Murthy Endowment R.N. Dr. Dr. Usha Punja - Award Fund for Nursing Students for Nursing Fund Punja Usha - Award Dr. Dr.Anisya Vasanth Meml. Oration Fund Meml. Vasanth Dr.Anisya Dr.Anisya Vasanth Memorial Fund for NMD Memorial Fund Vasanth Dr.Anisya Dr.D.N. Prasad Oration Fund Prasad Dr.D.N. Dr.R.N.Moorthy Mental Health & Neuro Sciences Mental Health & Neuro Dr.R.N.Moorthy Earned Leave Encashment Fund Epilepsy Research Fund Epilepsy Research Golden Jubilee Award Fund Neuroradiology Fund Golden Jubilee Award Govindaswamy Memorial Govindaswamy Prize Fund Carried Amount Forward Govindaswamy Murthy RaoGovindaswamy Memorial Fund Biological Fund Research Human Brain Bank for M. Fund Bio Research Human Brain Bank for Neuro Celebration Fund Day Independence Day/Republic
National Institute of Mental Health and Neuro Sciences 347 Annual Report 2015-2016 7,232 86,727 65,250 17,000 36,000 67,489 1,64,575 7,34,318 5,10,456 2,04,059 1,16,199 4,00,024 3,06,284 18,93,156 25,65,865 15,27,726 25,00,000 14,10,196 ------3,000 44,518 4,000 60,489 45,632 38,400 86,727 65,250 17,000 36,000 1,64,575 2,33,423 1,29,423 1,04,000 5,10,456 1,23,443 56,197 67,246 1,16,199 1,83,995 1,07,995 76,000 25,65,865 53,13,909 72,42,990 (19,29,081) 18,98,151 1,29,283 17,68,868 25,00,000 1,27,90,604 51,63,046 76,27,558 ------2,04,059 4,132 47,518 5,166 64,489 6,839 67,489 31,847 7,34,318 80,300 15,27,726 43,870 5,55,017 20,091 11,588 2,41,973 5,43,429 10,000 2,31,973 17,204 3,06,284 99,643 14,10,196 8,37,112 7,51,437 1,04,53,434 2,02,012 1,31,46,056 1,00,000 31,42,991 5,37,049 1,03,53,434 1,26,09,007 13,311 31,29,680 1,11,762 18,93,156 4,00,024 4,00,024 -Sd------65,250 y FinancialOfficer & Chief Accounts Advisor - - Deput 42,000 1,91,423 43,386 60,776 62,667 45,632 86,727 59,324 17,000 60,650 36,000 1,64,575 7,02,471 5,10,456 5,11,147 2,04,059 2,21,882 1,16,199 3,13,909 50,00,000 2,89,080 1,07,995 76,000 29,40,979 96,16,322 17,81,394 58,91,604 25,65,865 68,99,000 14,47,426 12,95,201 6,02,950 25,00,000 13,10,553 1,23,94,619 3,25,68,85,741 16,07,355 14,60,71,704 3,40,45,64,800 23,19,87,031 3,17,25,77,769 1,11,09,65,782 44,53,08,090 5,89,25,580 ,61,51,99,452 4,66,53,789 1,56,85,45,663 4,41,31,88,753 45,98,12,735 20,76,08,723 5,08,06,10,210 29,21,87,102 4,78,84,23,108 TOTAL Neurology Golden Jubilee Fund Neurology Neurosurgery Corpus Fund Fund Research Neuromuscular Neuro Psychiatric Genetics Fund Psychiatric Neuro Neurosurgery Fund Neurocon Neurosurgery Corpus Fund Brought Forward Amount Forward Brought for Excellence Fund Award Infosys Foundation De-Addiction Orientation Programme Joint Conference Research Fund Research Joint Conference (CD4/CD8) Fund KSAPS OncologyNeuro Fund Research NIMHANS Sundaram Clayton Fund R.F Disorders Disease and Movem’t Parkinson’s Perinatal Psychiatry Services Psychiatry Perinatal Fund Mrs. Rajeswarai Fund Krishnamurthy Endowmnet Mrs. Fund Information Centre Neuroscience National & Gratuity Fund Pension Nerve InjuryPeripheral Fund Management and Research Acount Fund Sivarajan Award V. Professor Rabies Diagnostic Services of Neurovirology - Dept. Account CorpusResearch Fund Mukund Memorial Award Fund Mukund Memorial Award IllnessNational Assitance Fund Fund Poor Fund Donation Research Wilsons Disease Corpus Fund Research Fellowship in RMC / KSM / GNNR in RMC / KSM Fellowship Research Lucture Fund Volunteers Schizophrenia and Depression Research Fund Research Schizophrenia and Depression Subhadra Fund Rao Dayananda Endowment TMC Fund Research Student Association Nurses
348 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedule Forming Part of Balance Sheet as at 31St March 2016
SCHEDULE - 4 - CURRENT LIABILITIES AND PROVISIONS
(Rs. In Lakh) PARTICULARS 2015-16 2014-15 A. CURRENT LIABILITIES 1. Sundry Creditors & Deposits: a) EMD, SD, CMD 692.69 1,298.16 b) Trade Payables & others 1,578.08 2,270.77 189.13 1,487.29
2. Statutory Liabilities: a) Overdue - - b) Others 122.43 122.43 93.76 93.76
3. Other Current Liabilities 1,761.74 1,761.74 1,616.16 1,616.16 TOTAL (A) 4,154.94 3,197.21 B. PROVISIONS - - TOTAL (B) - - TOTAL (A+B) 4,154.94 3,197.21
-Sd- Deputy Financial Advisor & Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 349 Annual Report 2015-2016
as at As on Net Block Net 31-03-2015 31-03-2015 (Rs. In lakh) (Rs.
0.79 0.79 3.60 3.60 32.91 31.99 71.71 71.71 177.59 161.45 300.00 300.00 as at As on 2,837.04 2,602.36 3,051.93 2,800.19 Net Block Net 35,274.26 25,209.70 31-03-2016 31-03-2016 - - -
- - - - -
- 2,873.30 294.89
2016 Total Total 2016 Upto 31-03- Depreciation engaluru ------
- -
- arch
2015-16 M for the year Depreciation t S - - -
- - - - -
- 31 t
a 2015
S 27,182.35 4,737.67 31,920.02 38,326.19 28,009.89 Upto 31-03- Depreciation Accumulated T as
t -Sd-
- - -
- - -
- 27,182.35 4,737.67 31,920.02 32,400.96 24,914.81 -
ASSE
(%) hee Rate of S depreciation
- FIXED y FinancialOfficer & Chief Accounts Advisor 0.79 3.60
32.91 71.71 0.00 437.36 25.00 98.53 92.75 191.28 246.08 58.30 604.01 50.00 293.91 178.34 472.25 131.76 46.54 401.78 50.00 300.29 63.47 363.76 38.02 76.23 150.06 10.00 85.36 10.59 95.95 54.11 36.02 220.57 10.00 41.23 22.06 63.29 157.28 76.22 177.59 300.00 0.00 5 : 5 : 2016 alance 1,570.19 10.00 296.34 157.02 453.36 1,116.83 1,025.80 2,355.43 10.00 966.01 196.66 1,162.67 1,192.76 1,013.33 1,392.91 25.00 653.13 249.27 902.40 490.51 384.80 2,837.04 3,051.93 Deput 24,290.49 5.00 9,306.75 1,170.27 10,477.02 13,813.47 13,961.92 67,372.91 as at 31-03- Total Total Assets B ------
------
of
t year ar during the Deductions Transferred SCHEDULE P - -
- -
ions year Additions during the Addit or m ing F
0.79 3.60 31.99 0.92 71.71 156.83 280.53 376.52 25.26 121.38 28.68 117.45 103.12 161.45 16.14 300.00 294.89 3,699.92 1,121.51 1,322.14 248.05 1,979.34 376.09 1,037.93 354.98 2,602.36 234.68 2,800.19 251.74 04-2015 Balance as at 01- Opening 23,004.74 9,542.24 20.51 32,526.47 10.00 15,140.80 2,597.24 17,738.04 14,788.43 7,863.94 23,268.67 1,021.82 52,097.16 12,244.33 20.51 64,320.98 54,897.35 12,496.07 Gross BlockGross chedule S NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, B SCIENCES, & NEURO HEALTH INSTITUTE OF MENTAL NATIONAL PARTICULARS ment
SUB-TOTAL (A) SUB-TOTAL Software E Journals (Perpetual License)E Journals (Perpetual 340.45 263.56 Books Vehicles Electrical Insatallations GRAND TOTAL (A+B) TOTAL GRAND Office Equipment SUB-TOTAL (B) SUB-TOTAL Furniture Library Books Computers Software Equipment Furniture & fixtures Furniture Buildings Computers Leasehold Land
Equip Land CAPITAL WORK-IN-PROGRESS CAPITAL ASSETS - PROJECTS
350 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedule Forming Part of Balance Sheet as at 31St March 2016
SCHEDULE - 6 - INVESTMENTS FROM EARMARKED / ENDOWMENT FUNDS
(Rs. In Lakh) PARTICULARS 2015-16 2014-15 1. In Government Securities 5,388.42 5,373.67 2. In Public Sector Banks 20,634.18 14,712.61 TOTAL 26,022.60 20,086.28
SCHEDULE - 7 - INVESTMENT - OTHERS
(Rs. In Lakh) PARTICULARS 2015-16 2014-15 1. Short term investments in Public Sector Banks 10,442.19 13,744.66 TOTAL 10,442.19 13,744.66
-Sd- Deputy Financial Advisor & Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 351 Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedule Forming Part of Balance Sheet as at 31St March 2016
SCHEDULE - 8 - CURRENT ASSETS, LOANS, ADVANCES, ETC.,
(Rs. In Lakh) PARTICULARS 2015-16 2014-15 A. CURRENT ASSETS 1. Inventories a) Stock of Consumables (Hospital & Others) 473.01 303.95 b) Stationery on hand 17.12 490.13 22.10 326.05 2. Sundry Debtors 260.56 98.55 3. Cash Balances in hand (Including cheques / drafts and imprest) 3.87 3.82 4. Bank Balances - With Scheduled Banks 1,590.60 1,855.03 2,657.69 2,760.06 TOTAL (A) 2,345.16 3,086.11 B. LOANS, ADVANCES AND OTHER ASSETS 1. Loans a) Staff 24.36 25.00 b) Advance Receivables 404.98 210.18 c) Prepaid Expenses 326.91 225.29 d) Tax Deducted at Source (recoverable) 96.76 114.20 e) Margin Money Deposits (LC) including opening charges 11,811.35 6,714.04 2. Advances to Suppliers 605.92 13,270.28 5,267.35 12,556.06 3. Advances & Other amounts recoverable in cash or in kind or for value to be received a) Contingencies and Purchases/suppliers 176.07 115.85 b) Due from Govt. of India 1,049.79 - c) Deposits 121.14 105.21 d) Receivable from General Provident Fund 243.91 188.69 4. Interest Receivable 2,644.05 4,234.96 1,961.21 2,370.96 TOTAL (B) 17,505.24 14,927.02
TOTAL (A+B) 19,850.40 18,013.13
-Sd- Deputy Financial Advisor & Chief Accounts Officer
352 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedules Forming Part of Income & Expenditure for the Year Ended 31St March 2016
SCHEDULE - 9 - INCOME FROM SALES / SERVICES
(Rs. In Lakh) PARTICULARS 2015-16 2014-15 1. Income from Sales - DP & NR 27.19 30.46 2. Income from Services i) Hospital Services 3,008.25 2,572.77 2,603.23 ii) Yoga Center 0.58 3,036.02 - TOTAL 3,036.02 2,603.23
SCHEDULE - 10 - GRANTS / SUBSIDIES (IRREVOCABLE GRANTS & SUBSIDIES RECEIVED)
(Rs. In Lakh) PARTICULARS 2015-16 2014-15 1. Central Government i) Plan 7,000.00 5,527.00 ii) Non-Plan 13,500.00 12,017.00 iii) De-Addiction 550.00 21,050.00 570.00 18,114.00 2. State Government i) Plan 400.00 400.00 ii) Non-Plan 5,100.00 5,100.00 iii) Capacity Building - 5,500.00 - 5,500.00 3. ICMR Grants 283.12 283.12 139.60 139.60 TOTAL 26,833.12 23,753.60
-Sd- Deputy Financial Advisor & Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 353 Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedules Forming Part of Income & Expenditure for the Year Ended 31St March 2016
SCHEDULE - 11 - FEES / SUBSCRIPTIONS
(Rs. In Lakh) PARTICULARS 2015-16 2014-15 1. Fees (Academic Section) 685.60 370.90 TOTAL 685.60 370.90
SCHEDULE - 12 - INCOME FROM GOVERNMENT SECURITIES/ BONDS (Rs. In Lakh) PARTICULARS 2015-16 2014-15 1. Interest a) On Govt. Securities - - b) Other Bonds / Debentures - -
TOTAL - -
-Sd- Deputy Financial Advisor & Chief Accounts Officer
354 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedules Forming Part of Income & Expenditure for the Year Ended 31St March 2016
SCHEDULE - 13 - INTEREST INCOME
(Rs. In Lakh) PARTICULARS 2015-16 2014-15 1. On Bank Account including FDRs: a) With Scheduled Banks 1,168.81 758.18 b) Accrued Interest (SB & FD) 466.35 1,635.16 985.00 1,743.18 2. On Loans: a) Employees / Staff - HBA 0.45 - b) Others - MCA 0.22 0.67 - - TOTAL 1,635.83 1,743.18
SCHEDULE - 14 - OTHER INCOME (Rs. In Lakh) PARTICULARS 2015-16 2014-15 1. Fees for Miscellaneous Services a) Water & Electricity Charges 28.42 44.88 b) NHS 63.01 91.43 59.69 104.57 2. Miscellaneous Income a) Miscellaneous Receipts 299.27 304.82 b) Convention Centre 160.79 168.54 c) Project Overhead 73.84 70.50 d) Donation 5.72 7.45 e) Hostel Rent 227.12 213.60 f ) Tender Forms and Publications 15.05 781.79 11.30 776.21 TOTAL 873.22 880.78
-Sd- Deputy Financial Advisor & Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 355 Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedules Forming Part of Income & Expenditure for the Year Ended 31St March 2016
SCHEDULE - 15 - ESTABLISHMENT EXPENSES (Rs. In Lakh) PARTICULARS 2015-16 2014-15 1. Salaries & Wages (a) Non-Plan 7,483.46 11,333.12 (b) Plan 5,654.58 4,022.89 (c) Wages 348.50 13,486.54 343.23 15,699.24 2. Stipend and Residential benefits 2,509.14 2,192.31 3. Contribution to Other Fund (LS & PC) 6.60 6.25 4. Contribution to Pension Fund - 10,220.06 5. Medical Treatment 419.94 2,935.68 455.68 12,874.30 TOTAL 16,422.22 28,573.54
-Sd- Deputy Financial Advisor & Chief Accounts Officer
356 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedules Forming Part of Income & Expenditure for the Year Ended 31St March 2016
SCHEDULE - 16 - OTHER ADMINISTRATIVE EXPENSES, ETC., (Rs. In Lakh) PARTICULARS 2015-16 2014-15 1 Drugs 760.22 567.17 2 Diet Expenses 122.30 85.61 3 HNS 325.94 352.19 4 Linen 71.99 51.81 5 Gas & Oxygen 46.30 44.96 6 Chemicals 39.50 32.38 7 Animal House 11.52 9.97 8 Liveries 4.70 7.32 9 Lab Equipments & Apparatus 5.96 5.44 10 Electricity Charges 692.68 625.63 11 Water Charges 546.77 444.90 12 Repairs & Maintenance (Buildings, Garden & BME) 896.33 364.65 13 Rent, Rates and Taxes 12.09 7.51 14 Vehicles Running and Maintenance 29.53 27.62 15 Postage, Telephone and Communication Charges 55.95 35.90 16 Printing and Stationary 55.57 42.67 17 Travelling and Conveyance Expenses 149.53 122.40 18 Hospital Contingencies 0.99 1.08 19 Security and Cleaning 1,461.17 1,197.55 20 Miscellaneous Expenses 66.23 37.88 21 Office Contingencies 84.92 74.52 22 DP & NR 20.35 18.08
National Institute of Mental Health and Neuro Sciences 357 Annual Report 2015-2016
23 Equipment Contingencies 1,161.97 1,350.35 24 Drug De-Addiction Centre 238.98 228.53 25 Convention Centre 18.64 30.05 26 National Mental Health Survey 379.33 - 27 National Mental Health Survey - Prior Period Expenses (2014-15) 18.38 - 28 Corpus Fund for Developmental Works 4,000.00 - 29 Books & Periodicals & Binding 2.33 - 30 Fuel to Generator 36.10 33.93 31 E-Journals and Database 46.89 203.52 32 Information Technology 51.65 14.15 33 Furniture & Fixture - Maintenance 3.80 2.83 34 Research and Development 101.26 57.10 35 Professional Charges & Consultancy 25.42 17.23 36 Centre for Public health 6.63 53.94 37 Advertisement 22.42 27.30 38 Interventional Implants 224.36 129.60 39 Yoga Centre 12.15 5.47 40 Brain Bank 16.50 115.55 TOTAL 11,827.35 6,426.79
-Sd- Deputy Financial Advisor & Chief Accounts Officer
358 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedules Forming Part of The Accounts for the Period Ended 31St March 2016
SCHEDULE-17 –SIGNIFICANT ACCOUNTING POLICIES
1. SYSTEM AND METHOD OF ACCOUNTING: Fixed Assets which were acquired prior to the cut-off-date, as The accounts have been prepared under the Historical Cost tabled below, are fully depreciated. Convention with Accrual system of accounting. Particulars Cut-Off-Date 2. The Provident Fund established for the benefits of the Buildings 31/03/1995 employees of NIMHANS, Bangalore has been recognized Equipment & Tolls, Furniture and Vehicles 31/03/2005 under Sub-Section (2) of Sec. 8 of the Provident Funds Act, 1925 (19 of 1925) by the Govt. of India, Ministry of Finance Computers, Accessories and Software 31/03/2011 vide Notification No. 4 (1)-E.V. 192 (I), dated 24th December Library Books, Journals & Database with 31/03/2013 1992. Perpetual License
3. FIXED ASSETS: 4. INVENTORY: Fixed assets are accounted at Historical cost of acquisition Stock of Drugs, Chemicals, Linen, Stationery and other including inward freight, duties & taxes and incidental Stores were taken at cost as per the Physical verification and and direct expenses related to acquisition, installation and Certificates issued by Departmental Heads as on 31/03/2016. commissioning. 5. INVESTMENTS: Fixed assets have been valued at cost less accumulated All Investments are valued at cost. depreciation. Depreciation on Fixed assets is provided on Straight Line Method at the following Rates. 6. GOVERNMENT GRANTS: Grants received from Government of India and Government of Karnataka under Plan (General) and Non-Plan are treated as Percentage of Particulars Depreciation Revenue unless they are Capital Grants. Plan Grants (Capital) were utilized in acquiring Fixed Assets and are directly Land 0% accounted under Capital Fund Account-Schedule 1. Buildings 5%
Equipment, Office Equipment, Electrical 10% 7. INVESTMENT OF EARMARKED/ENDOWMENT Installations and Vehicles FUNDS AND INTEREST ACCRUED ON SUCH Computers, Peripherals and Software 25% INVESTMENTS : Library Books, E-Journals and Database 50% Incomes earned on various Investments including Earmarked with Perpetual License Investments have been recognized on accrual basis subject to materiality. Interest received on maturity are credited to Depreciation is provided for the full year on addition of assets the concerned fund account. Interest accrued on Earmarked/ acquired during the year. Assets acquired from the Earmarked Endowment Fund are disclosed under ‘Interest Receivables’. Funds, where the ownership of such assets vests with the Institute, are included as the Fixed Assets of the Institute. 8. RETIREMENT BENEFITS: Assets acquired from project funds are treated as project assets The Actuarial Valuation of pension liability and gratuity was and no depreciation has been claimed on such assets. carried out by a qualified actuary. The valuation certificate
National Institute of Mental Health and Neuro Sciences 359 Annual Report 2015-2016
recommended a total service liability of Rs.292.06 crore on 11. TAXATION: Pension and Gratuity. No additional liability has been created The Institute is not liable to Income Tax as it is exempt under during the year as the carried forward liability exceeds the Se. 10(23)(c)(iiiab) & 10(23)(c)(iiiac) of the Income Tax Act, actuarial valuation. As against the total provision of Rs.317.25 1961, hence no provision has been made towards taxes. crore carried on the liabilities side of the balance sheet, the Fund Deposits against this provision is only Rs.185.20 crore. 12. Govt. of India, Ministry of Home Affairs have accorded permissions to the Institute to accept Foreign contributions 9. A provision of Rs. 37.78 crores has been made towards leave vide their letter No. 11/2012/69(120)/1998-FCRA-III, dated encashment as per the actuarial valuation but no fund deposit 1st October 2003 and Registered under Section 6(1)(a) of the has been created by the Institute towards this. Act with Registration Number: 094420795, under the category, Educational Social. 10. Figures of earlier year have been re-grouped to make comparable with the figures of the current year, wherever necessary.
-Sd- -Sd- Deputy Financial Advisor & DIRECTOR Chief Accounts Officer
360 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
Schedules Forming Part of The Accounts for the Period Ended 31St March 2016
SCHEDULE-18 – NOTES ON ACCOUNTS FORMING PART OF INCOME AND EXPENDITURE ACCOUNT AND BALANCE SHEET
1. The Annual Accounts for the year 2015-16 is prepared on crore carried on the liabilities side of the balance sheet, the Accrual basis. Fund Deposits against this provision is only Rs.185.20 crore.
2. Liabilities are recognized and considered on receipt of bill of 8. A provision of Rs. 37.78 crore has been made towards leave materials/ equipment both in respect of Current and Other encashment as per the actuarial valuation but no fund deposit Liabilities. has been created by the Institute towards this.
3. In respect of NIMHANS HEALTH SCHEME, for Ex- 9. employees of the Institute, the liability towards health care (i) Land (145 acres and 4480Sq.ft.) was allotted free of cost facility to be provided cannot be quantified and therefore no by Government of Karnataka in the past. The land value (Rs. provision has been made towards it. 71.71 lakh) shown under ‘Schedule 5- Fixed Assets’ represents incidental expenditure incurred in connection with acquisition. 4. Subscription to E-Journals and Database is an intangible asset and amortized over its useful life, including in the year of (ii) During the year 2012-13 NIMHANS has been allotted purchase. Land to the extent of 39 Acres and 38 Guntas at Kyalasanahalli, Bangalore, (30 Acres 38 Guntas is in possession and 9 Acres 5. Current assets, Loans and Advances have a realizable value in is in the process of transfer of possession) by Government of the ordinary course of business, equal to the aggregate amount Karnataka on lease basis. Two installments of the lease amount shown In the Balance Sheet. of Rs. 3 Crore (Fixed) for 30 years, payable @ Rs.50.00 lakh per year at 6 yearly installments, has been paid so far. 6. Schedules 1 to 18 are annexed to and form an integral part of the Balance sheet as at 31st March 2016 and the Income and 10. An Amount of Rs. 276.76 Lakhs has been received during the Expenditure Account for the Year ended that date. financial year 2015-16 as foreign contributions and accounted under FF A/c No.:54004656310. 7. The Actuarial Valuation of pension liability and gratuity was carried out by a qualified actuary. The valuation certificate 11. In order to facilitate Developmental Works, a decision has been recommended a total service liability of Rs.292.06 crore on taken to augment further resources of Rs. 4000.00 lakhs in to Pension and Gratuity. No additional liability has been created the existing Corpus Fund for Development Works account during the year as the carried forward liability exceeds the thereby and the same has been transferred by charging the actuarial valuation. As against the total provision of Rs.317.25 revenue account during the year.
-Sd- -Sd- Deputy Financial Advisor & DIRECTOR Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 361 Annual Report 2015-2016
Separate Audit Report of the Comptroller and Auditor General of India on the Accounts of the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore for the Year Ended 31 March 2016 and Reply of National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore
SEPARATE AUDIT REPORT OF THE COMPTROLLER REPLY OF NATIONAL INSTITUTE OF MENTAL HEALTH AND AUDITOR GENERAL OF INDIA ON THE ACCOUNTS AND NEURO SCIENCES (NIMHANS), BANGALORE OF THE NATIONAL INSTITUTE OF MENTAL HEALTH AND NEURO SCIENCES (NIMHANS), BANGALORE FOR THE YEAR ENDED 31 MARCH 2016
1. We have audited the attached Balance Sheet of the National Institute of Mental Health and Neuro Sciences, Bangalore as at 31 March 2016 and the Income and Expenditure Account / Receipt & Payment Account for the year ended on that date under Section 20(1) of the Comptroller and Auditor General’s (Duties, Powers and Conditions of Service) Act, 1971. The audit of the Institute has been entrusted from 2015-16 to 2019-20. These financial statements are the responsibility of the Institute’s Management. Our responsibility is to express an opinion on these financial statements based on out Audit.
2. This Separate Audit Report contains the comments of the Comptroller and Auditor General of India on the accounting treatment only with regard to classification, conformity with the best accounting practices, accounting standards and disclosure norms, etc. Audit observation on financial transactions with regard to compliance with the Law, Rules and Regulations (Propriety and Regularity) and efficiency-cum-performance, etc, if any are reported through Inspection Reports / Comptroller & Auditor General’s Audit Reports separately.
3. We have conducted our audit in accordance with auditing standards generally accepted in India. These standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free from material mis-statements. An audit includes examining on a test basis, evidences supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of financial statements. We believe that our Audit provides a reasonable basis for our opinion.
4. Based on audit, we report that:
i. We have obtained all the information and explanations, which to the best of our knowledge and belief were necessary for the purpose of our audit.
362 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
ii. The Balance Sheet and Income & Expenditure Account / Receipt & Payment Account dealt with by this report have been drawn up in the format approved by the Institute’s Board of Management and Finance Committee.
iii. In our opinion, proper books of accounts and other relevant records have been maintained by the Institute as required in so far as it appears from our examination of such books:
iv. We further report that:
A. REVISION OF ACCOUNTS A REVISION OF ACCOUNTS The Institute has revised the annual accounts on 24.08.2016, based on the audit observation and the Draft Separate Audit Facts Confirmed. Report issued on 05-08-2016. The effect of revision of accounts was that the Assets and Liabilities decreased by Rs.0.18 crore.
B. COMMENTS ON ACCOUNTS: B. COMMENTS ON ACCOUNTS I. Fixed Assets – Schedule 5 I. Fixed Assets – Schedule 5 Equipments amounting to Rs.1.18 crore purchased during The necessary corrections will be made in the books of Accounts 2015-16, installed in 2016-17 were wrongly accounted as assets for the year 2016-17. instead of showing under works in progress. Further, provision of proportionate depreciation of Rs.0.11 crore threreon has resulting in overstatement of depreciation and understatement of surplus to that extent.
II. Loans, Advances and Other Assets – Schedule 8 II. Loans, Advances and Other Assets – Schedule 8 Cost of accessories amounting to Rs.5.31 crore were not An amount of Rs.5.31 crore was not capitalized since the same capitalized though the relevant equipments were capitalized are purely accessories in nature. and commissioned on pilot basis in January 2016. This resulted in understatement of Fixed Assets and overstatement of Loans, Advances & Other Assets to the extent of Rs.5.31 crore. Further, depreciation applicable to the extent of Rs.0.26 crore thereon was not charged, resulting in overstatement of Excess of Income over Expenditure to that extent.
C. GRANTS-IN-AID: C. GRANTS-IN-AID The financial position of the NIMHANS, Bengaluru funded by Government of India for the financial year 2015-16 is as Facts Confirmed follows: (Rs. In crore) Opening Grants received Total Grants Project Balance 2015-16 Grants Utilized Government 50.70 290.50 341.20 341.20 of India
v. We report that the Balance Sheet and Income & Expenditure Account / Receipts & Payments Account dealt with by this report are in agreement with the books of Accounts.
National Institute of Mental Health and Neuro Sciences 363 Annual Report 2015-2016
vi. In our opinion and to the best of our information and according to the explanations given to us, the said financial statements read with the Accounting policies and Notes on Accounts, and subject to the matters stated above and other matters mentioned in Annexure to this Audit Report give a true and fair view in conformity with accounting principles generally accepted in India
a. In so far as it related to the Balance Sheet, of the state of affairs of the National Institute of Mental Health & Neurosciences, Bangalore as at 31st March 2016; and
b. In so far as it relates to Income & Expenditure Account of the surplus for the year ended on that date
For and on behalf of the C & AG of India Sd/- Sd/- Place: Bangalore PRINCIPAL DIRECTOR OF Place: Bangalore DIRECTOR, NIMHANS Date: 29 September 2016 AUDIT (CENTRAL) BANGALORE Date: 29 September 2016
364 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
ANNEXURE
1. Adequacy of Internal Audit System 1. Adequacy of Internal Audit System Action will be taken to deploy more strength in the Internal Internal Audit Wing is responsible to audit all transaction and Audit wing in order to take care of the deficiencies pointed out advice the authorities on rules and regulations from time to time. by the Audit However, shortcomings were noticed in certain important areas like local purchases, rate contracts, labour contracts entered into by the Institute, verification of utilization certificates and audit of all contingencies including security, housekeeping, hospital bills, claims etc., In the view of the above, the Internal Audit System needs to be strengthened
2. Adequacy of Internal Control System 2. Adequacy of Internal Control System The Institute opened Letter of Credit (LC) for purchase of The Internal control systems as pointed by the Audit will equipments under Capital Grants. However, the liabilities be improved in a phased manner through the Internal Audit are cleared by debiting Institutes parking account; thereby the control. liabilities are not discharged by closing the LC’s. Thus, apart from internal audit & other control needs to be strengthened.
3. Adequacy of System of Physical Verification of Inventory: Factual – No Remarks The Institute is conducting physical verification of Inventory annually.
4. Adequacy of System of Physical Verification of Fixed Assets Factual – No Remarks The Institute is conducting phycial verification of Fixed Assets regularly.
5. Regularity in payment of statutory dues: Factual – No Remarks The Institute is regular is making all the statutory dues.
Sd/- PRINCIPAL DIRECTOR OF Sd/- AUDIT (CENTRAL) BANGALORE DIRECTOR, NIMHANS
National Institute of Mental Health and Neuro Sciences 365 Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
PROVIDENT FUND ACCOUNT
Balance Sheet as at 31St March 2016
(Rs. In Lakh) CORPUS / CAPITAL FUND & LIABILITIES 2015-16 2014-15 CAPITAL FUND Opening Balance 5,512.44 4,494.25 Add: Contribution from employees 1,610.45 1,737.18 Add: Excess of Income over Expenditure 22.52 8.54 Add: Loan amount credit to Capital account - 346.77 7,145.41 6,586.74 Less: Payments during the year 1,574.84 5,570.57 1,074.30 5,512.44
CURRENT LIABILITIES Payable to Institute 243.91 243.91 188.69 188.69 TOTAL 5,814.48 5,701.13 ASSETS INVESTMENTS - FROM EARMARKED / ENDOWMENT FUNDS (a) In Government Securities 1,691.29 1,685.00 (b) In Public Sector Banks 2,943.77 2,619.21 (c) In RBI Special Deposits 414.09 5,049.15 414.09 4,718.30
CURRENT ASSETS Cash at Canara Bank 283.70 429.49 Loan to Employees 285.68 346.77 Interest on Investments Receivables 195.95 765.33 206.57 982.83 TOTAL 5,814.48 5,701.13
-Sd- -Sd- -Sd- Deputy Financial Advisor & REGISTRAR DIRECTOR Chief Accounts Officer
366 National Institute of Mental Health and Neuro Sciences Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
PROVIDENT FUND ACCOUNT
Income & Expenditure Account for the Year Ended 31St March 2016
(Rs. In Lakh) INCOME 2015-16 2014-15 Interest Earned on Investments 235.21 186.92 Accrued Interest Earned on Investments 195.95 206.57
TOTAL (A) 431.16 393.49 EXPENDITURE Bank charges 0.03 0.03 Amount Credited to Employee’s Provident Fund Account including Bank charges 408.61 384.92
TOTAL (B) 408.64 384.95 Balance being excess of Income over Expenditure (A-B) Transfer to Capital Account 22.52 8.54 TOTAL 431.16 393.49
-Sd- -Sd- -Sd- Deputy Financial Advisor & REGISTRAR DIRECTOR Chief Accounts Officer
National Institute of Mental Health and Neuro Sciences 367 Annual Report 2015-2016
NATIONAL INSTITUTE OF MENTAL HEALTH & NEURO SCIENCES, Bengaluru
PROVIDENT FUND ACCOUNT
Receipts and Payments for the Year 2015-16
(Rs. in Lakh) RECEIPTS 2015-16 2014-15 PAYMENTS 2015-16 2014-15 Opening Balances GPF and CPF Payments 1,541.02 1,074.30 (Payments of Advances, Withdrawals Bank Balance and 3803 - Canara Bank 429.49 317.46 Final Settlement) Interest Charges 0.03 0.03 GPF Receipts 1,186.93 1,310.26 CPF Receipts 2.65 11.05 Investments 1,090.60 399.00 (Subscription & Contribution) Repayments of loan amount 39.52 30.93 Closing Balances Cash Balance Interest Receipts 1,256.76 233.12 3803 - Canara Bank 283.70 429.49
TOTAL 2,915.35 1,902.82 TOTAL 2,915.35 1,902.82
-Sd- -Sd- -Sd- Deputy Financial Advisor & REGISTRAR DIRECTOR Chief Accounts Officer
368 National Institute of Mental Health and Neuro Sciences Homage
Sri. BC Shivanna, Hospital Assistant 05.08.2015 Dr. Jayashree Ramakrishna, Prof. of Mental Health Education 27.09.2015 Dr. SN Madhusudana, Prof. of Neurovirology 02.12.2015 Sri. BN Mahadeva, MTS 06.12.2015 Sri. Shamanna, Hospital Assistant 20.12.2015 NATIONAL INSTITUTE OF MENTAL HEALTH AND NEURO SCIENCES P.B. No. 2900, BENGALURU - 560 029, India
Telephone: +91 - 80 - 2699 5000 / 2699 5100 / 2699 5200 Fax: +91 - 80 - 2656 4830 / 2656 2121 Email: [email protected] / [email protected] Website: http://www.nimhans.ac.in
E diTOR-in-Chief Prof. B. N. Gangadhar Director NIMHANS, Bengaluru
Co-ordinators Dr. S. Sampath Professor & Head, Department of Neurosurgery Dr. N. Girish Additional Professor of Epidemiology Dr. Santosh Loganathan Associate Professor of Psychiatry Dr. Poornima Bhola Associate Professor of Clinical Psychology Dr. Vikas Associate Professor of Neurosurgery Dr. Naren P. Rao Associate Professor of Psychiatry Dr. K. S. Meena Assistant Professor of Mental Health Education Dr. B. N. Srikumar Assistant Professor of Neurophysiology Photo Credits Editorial Team Dr. K. S. Meena, Assistant Professor of Mental Health Education English Mr. Vasudeva Manja A, Sr. Photographer, Department Mr. Prabhu Dev M, Assistant Editor of Mental Health Education Mrs. Tejaswini A, Publication Dept. Mrs. Beereshwari, Publication Dept. Mr. K. Manjunath, HBTR, Dept. of Neuropathology Mrs. T.D. Jayalakshmi, Publication Dept. Ms. Jasmine Mary John, PhD Scholar, Department of Psychiatric Social Work Hindi Front Cover: Front view of the Department of Prof. Mahendra P. Sharma, Hindi Officer Psychiatry Mr. Shinde Pandurang, Hindi Cell Mrs. A. Dhanalakshmi, Hindi Cell Back Cover: NIMHANS Anthem
Design and Printing: Aditi Enterprises, Bengaluru - 560 023, Phone: 080-2310 7302, E-mail: [email protected] Vasudeva Manja A K. Manjunath ANNUAL REPORT
NATIONAL INSTITUTE OF MENTAL HEALTH AND NEURO SCIENCES Institute of National Importance Bengaluru - 560 029 2015 - 2016 NIMHANS
ANNUAL REPORT | 2015 - 2016