Supplementary Table 1. Down-regulation of oligodendrocyte genes in schizophrenia

Schizophrenia ID Accession Symbol product fold change P value oligodendrocyte transcription factors 36018_at AJ001183 SOX10 SRY (sex determining region Y)-box 10 -1.60 0.001 40624_at U48250 OLIG2 oligodendrocyte lineage transcription factor 2 -1.30 0.019 32187_at AB028973 MYT1 myelin transcription factor 1 1.12 0.571 33539_at W28567 MYEF2 myelin expression factor 2 -1.04 0.887 oligodendrocyte-expressed genes 38558_at M29273 MAG myelin associated glycoprotein -1.76 0.004 41158_at M54927 PLP1 proteolipid protein 1 -1.50 0.011 38499_s_at D28113 MOBP myelin-associated oligodendrocyte basic protein -1.59 0.017 35903_at M63623 OMG oligodendrocyte myelin glycoprotein -1.15 0.022 38653_at D11428 PMP22 peripheral myelin protein 22 -1.28 0.058 38051_at X76220 MAL mal, T-cell differentiation protein -1.11 0.065 612_s_at M19650 CNP 2',3'-cyclic nucleotide 3' phosphodiesterase -1.17 0.072 32538_at S95936 TF transferrin -1.48 0.098 32612_at X04412 GSN gelsolin (amyloidosis, Finnish type) -1.23 0.118 39598_at X04325 GJB1 gap junction protein, beta 1, 32kDa -1.10 0.416 37867_at Z48051 MOG myelin oligodendrocyte glycoprotein 1.39 0.600 35328_at AF055023 NF1 neurofibromin 1 -1.03 0.973 35817_at M13577 MBP myelin basic protein 1.02 1 other oligodendrocyte-related genes 41346_at AJ007583 LARGE like-glycosyltransferase -1.02 0.786 32719_at L41827 NRG1 neuregulin 1 1.07 0.792 1585_at M34309 ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 -1.10 0.294 40387_at U80811 VZG1 venbtricular zone gene 1 -1.20 0.937 35109_at AB018299 NFASC neurofascin 1.00 0.964 40631_at D38305 TOB1 transducer of ERBB2, 1 -1.06 0.504 39286_at D64109 TOB2 transducer of ERBB2, 2 -1.03 0.917 other glial cells-expressed genes 40185_at S40719 GFAP glial fibrillary acidic protein 1.05 0.751 35185_at AJ002962 FABP7 fatty acid binding protein 7, brain 1.05 0.821

Our previous microarray data, which was originally analyzed by MAS4, was reanalyzed in the present study by MAS5 and imported into GeneSpring 6.1 software (SiliconGenetics, Redwood, CA, USA). Data normalization was performed by dividing each microarray data set by its median value. Oligodendrocyte-related probe sets were chosen based on previous DNA microarray reports and literature search. Among the 37 oligodendrocyte-related genes we probed for, probe sets for 11 genes were called as absence by MAS5 in our experiments. They were CLDN11, EGR2, ERBB2, ERBB4, MMP9, MPZ, MYT2, PAX3, PMP2, POU3F1, and NRG2. Mann-Whitney U-test was employed to identify differentially expressed probe sets. In cases where multiple probe sets were found in one gene, we chose the one showing the lowest P value.