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2018 EASTERN ANALYTICAL SYMPOSIUM & EXPOSITION ANALYTICAL SOLUTIONS TO THE WORLD’S PROBLEMS November 12-14, 2018 Crowne Plaza Princeton Conference Center Plainsboro, NJ ABSTRACT BOOK eas.org 003722-EAS_ProgramCover2018_8.5x11_v1.indd 1 10/23/18 12:01 PM 2019 EASTERN ANALYTICAL SYMPOSIUM & EXPOSITION 2019 EASTERN ANALYTICALENHANCING SYMPOSIUM & EXPOSITION ANALYTICAL CHEMISTRYENHANCING WITH SUSTAINABLEANALYTICAL SOLUTIONS CHEMISTRY WITH SUSTAINABLE SOLUTIONS Crowne Plaza Princeton Conference Center eas.org Crowne Plaza Princeton Conference Center eas.org Plainsboro, NJ NovemberPlainsboro, 18-20, NJ 2019 November 18-20, 2019 EAS invites YOU to be a part of Bioanalysis Capillary Electrophoresis the Technical Program next Chemometrics year. Conservation Science Environmental Analysis Forensic Analysis Contribute a paper for oral or Gas Chromatography poster consideration via our Liquid Chromatography Immunochemistry website. Industrial Hygiene IR/NIR/Raman Spectroscopy Laboratory Automation Laboratory Management Mass Spectrometry Microchemistry Microscopy NMR Spectroscopy Pharmaceutical Analysis Process Analytical Science Quality by Design Quality/Regulatory/Compliance Sample Preparation Science Education Separation Sciences SFC & Size Exclusion Chromatography Surface Science Vibrational Spectroscopy CALL for PAPERS 2019 Opens March 1st 2018 EAS Abstracts November 2018 2018 EAS Abstracts This volume contains the final abstracts for the oral and poster presentations which take place Monday, November 12, through Wednesday, November 14, 2018. If an abstract is not provided in this volume or the Addendum, then the presenting author did not supply an abstract. For each abstract provided, a complete mailing address for the presenting author is shown. Additional authors are indicated, however, their mailing addresses are not provided. More Information To obtain answers to EAS-related questions after the meeting: EAS Hotline 732-449-2280 EAS E-mail [email protected] EAS Web Site www.EAS.org Eastern Analytical Symposium & Exposition, Inc. P.O. Box 185 Spring Lake, NJ 07762 N N A ALY ER T T IC S A A L E S Y N M O P I T O I SI S U PO M & EX Save the Date The 2019 EAS November 18 - 20, 2019 Crowne Plaza Princeton – Conference Center Plainsboro, NJ We want you to be a part of the 58th Eastern Analytical Symposium! 2019 Call for Papers opens March 1 1 2018 EAS Abstracts November 2018 1 Hyperbranched Anion-Exchange Phases in Ion Chromatography rent efficiency of electrolytic suppressor devices. Additionally, we provide highlights Christopher Pohl, Thermo Fisher Scientific, 1228 Titan Way, Sunnyvale, of our investigations with various design configurations of the electrolytic suppressor CA 94085, Charanjit Saini to understand the root cause of the higher noise phenomena. We discuss two new Since initial work in 2003, hyperbranched anion-exchanged materials have been designs of the suppressor device, one design tailored for improved overall perfor- widely used in ion chromatography. This versatile synthetic platform has been em- mance under constant voltage mode of operation with the typical eluents used in ployed in more than ten different ion-exchange phases. Here we review the design suppressor IC, and the other design tailored for improved noise performance in the and synthesis of hyperbranched anion-exchange phases with a focus demonstrat- constant current mode with carbonate based eluents. ing the relationship between synthetic parameters and the resultant ion-exchange selectivity of hyperbranched phases. Application of hyperbranched phases for a 5 Raman Spectroscopy for Forensic Purposes and Medical variety of applications is demonstrated. Diagnostics Igor K. Lednev, University at Albany-SUNY, 1400 Washington Ave., 2 High-Performance Anion Exchange Chromatography and Pulsed Albany, NY 12222 Electrochemical Detection: An Ideal Couple for Carbohydrate Raman spectroscopy combined with advanced statistics is uniquely suitable for Analysis characterizing microheterogeneous samples. Understanding the structure and (bio) William R. LaCourse, University of Maryland Baltimore County, MS: chemical composition of samples at the microscopic level is important for many CNMS, 1000 Hilltop Circle, Baltimore, MD 21250 practical applications including material science, pharmaceutical industry, etc. We Pulsed electrochemical detection (PED) following chromatographic separation is a have recently demonstrated a great potential of Raman spectroscopy for disease powerful technique that revolutionized the analysis of underivatized polar aliphatic diagnostics and forensic purposes. In this presentation, we will discuss the devel- compounds. PED offers near universal detection of compounds that contain one opment of a new, noninvasive method for Alzheimer’s disease (AD) diagnostics or more alcohol, amine or sulfur moieties. The analytical utility of PED focuses on based on Raman spectroscopy of blood. Near infrared (NIR) Raman spectroscopy the use of potential-time (E-t) waveforms, which combine amperometric/coulometric coupled with advanced multivariate statistics was utilized for differentiating patients detection with alternated anodic and cathodic polarizations that maintain reproduc- diagnosed with Alzheimer’s disease, other types of dementia and healthy control ible electrode activity. From an historical perspective, waveform development has subjects with more than 95% sensitivity and specificity. When fully developed, this been premised on understanding the tenets of anodic oxygen transfer reactions at fast, inexpensive noninvasive method could be used for screening at risk patient noble metal electrode surfaces. Hence, a series of different waveforms (e.g., PAD, populations for AD development and progression. Raman spectroscopy has already IPAD, etc.) has been reported in the literature. The majority of effort in past years found numerous applications in forensic science providing confirmatory identifica- has almost exclusively focused on quantitative (i.e., sensitivity and lower limits of tion of analytes. The technique is non-destructive, rapid and requires little or no detection) measurements rather than qualitative information. The full benefit of PED sample preparation. Furthermore, portable Raman instruments are readily available for carbohydrate analysis is only realized when it is coupled with high-performance allowing for crime scene accessibility. We have recently demonstrated that Raman anion exchange chromatography (HPAEC). In this talk, the ideal coupling of HPAEC microspectroscopy can be used for the identification of biological stains at a crime and PED will be juxtaposed with the advantageous coupling of academia and indus- scene indicating the type of body fluid. In addition, peripheral and menstrual blood try that made it all possible. HPAEC-PED literally transformed carbohydrate anal- as well as human and animal blood can be differentiated. Phenotype profiling based ysis, and its collective impact on research across numerous industries has been on Raman spectroscopy of dry traces of body fluids is the next exciting challenge. significant. An historical overview of PED development will be presented with em- We will also discuss the application of Raman spectroscopy for detection and char- phasis on the mechanistic discoveries and applied utility at each stage of evolution. acterization of gunshot residue (GSR). Along the way, applications involving pharmaceutical and biological samples will be used to highlight the quantitative and qualitative aspects of this powerful technique. 6 T-Jump Resonance and Normal Raman Determination of Reaction Coordinate of Thermoresponsive Hydrogel Volume Phase 3 Open Tubular Capillary Ion/Liquid Chromatography: The Transition Challenges and the Rewards Sanford A. Asher, University of Pittsburgh, Rm. 701, 219 Parkman Purnendu K. Dasgupta, University of Texas - Arlington, 700 Planetarium Ave., Pittsburgh, PA 15260, Tsung-Yu Wu, Alyssa B. Zrimsek, Sergei V. Pl, Dept. Chem UTA, Arlington, TX 76019 Bykov, Ryan S. Jakubek Some 35 years ago, in addressing the future of open tubular liquid chromatography, The best-known examples of smart, responsive hydrogels derive from poly(N-iso- Jorgenson and Guthrie were prescient in identifying sensitive detection as the domi- propylacrylamide) (PNIPAM) cross-linked polymer networks. These hydrogels un- nant barrier in the path of its success. Techniques such as photoionization detection dergo volume phase transitions (VPTs) triggered by temperature, chemical, and/or and mass spectrometry, it was hoped, would be attractive solutions. PID has not environmental changes. PNIPAM hydrogels can undergo more than 50-fold volume quite lived up to that promise. Some types of nanospray mass spectrometry does changes within ~1 μs intervals. Studies have tried to elucidate the molecular mecha- today have the requisite sensitivity to be applicable, but at current costs, this would nism of these extraordinarily large responses. Nevertheless, the molecular reaction represent a high barrier of entry. Based on some comments by Golay, multicapillary coordinates that drive the VPT remain unclear. Using visible nonresonance Raman chromatography (MCC) was proposed as a solution also early on to remove the temperature-jump (T-Jump) spectroscopy and UV resonance Raman T-jump we de- extreme volume limitations during detection, with the hope that improved precision termined the molecular ordering of this VPT. The PNIPAM hydrophobic isopropyl in manufacturing technology will make this possible.