DOCSLIB.ORG

Recent Advances in the Treatment of Hematologic Malignancies

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Recent Advances in the Treatment of Hematologic Malignancies February 2009 www.clinicaladvances.com Volume 7, Issue 2, Supplement 6 With Commentaries From: Shaji Kumar, MD Associate Professor of Medicine Mayo Clinc Rochester, Minn Recent Advances in the S. Vincent Rajkumar, MD Professor of Medicine Mayo Clinc Treatment of Hematologic Rochester, Minn Malignancies John P. Leonard, MD Richard T. Silver Distinguished Professor Hematology and Medical Oncology Weill Cornell Medical College New York Presbyterian Hospital New York, NY A Review of Selected Presentations from the Kanti R. Rai, MD 50th Annual American Society of Hematology Chief, Division of Hematology/Oncology Meeting and Exposition Long Island Jewish Medical Center December 6–9, 2008 New Hyde Park, NY San Francisco, California Guillermo Garcia-Manero, MD Associate Professor Chief, Section of Myelodysplastic Syndromes Guest Editor: Department of Leukemia Bruce D. Cheson, MD, FACP The University of Texas M.D. Anderson Cancer Center Head of Hematology Houston, Tex. Lombardi Comprehensive Cancer Center Georgetown University Hospital Washington, DC A CME Activity Approved for 1.25 AMA PRA Category 1 Credit(s) TM Release Date: February 2009 Expiration Date: February 15, 2010 Estimated time to complete activity: 1 hour 30 minutes Project ID: 6188 Sponsored by Postgraduate Institute for Medicine Supported through educational grants from Celgene Corporation and Cephalon Inc. Table of Contents CME Certification Information and Faculty Disclosure 3 Introduction by Dr. Bruce D. Cheson 4 Summaries of Selected Presentations on Myeloma and Expert Commentary from Drs. Shaji Kumar and S. Vincent Rajkumar 6 Summaries of Selected Presentations on Lymphoma and Expert Commentary by Dr. John P. Leonard 13 Summaries of Selected Presentations on Leukemia and Expert Commentary by Dr. Kanti R. Rai 17 Summaries of Selected Presentations on Myelodysplastic Syndromes and Expert Commentary by Dr. Guillermo Garcia-Manero 23 CME Post-Test 31 CME Evaluation Form 32 Disclaimer Funding for this Presentations Review has been provided through an educational grant from Celgene Corporation and Cephalon Inc. Support of this monograph does not imply the supporter’s agreement with the views expressed herein. Every effort has been made to ensure that drug usage and other information are presented accurately; however, the ultimate responsibility rests with the prescribing physician. Millennium Medical Publishing, Inc, the supporters, and the participants shall not be held responsible for errors or for any consequences arising from the use of information contained herein. Readers are strongly urged to consult any relevant primary literature. No claims or endorsements are made for any drug or compound at present under clinical investigation. ©2009 Millennium Medical Publishing, Inc. 611 Broadway, Suite 310, New York, NY 10012. Printed in the USA. All rights reserved, including the right of reproduction, in whole or in part, in any form. Target Audience Dr. Guillermo Garcia-Manero: No real or apparent conflicts of interest This activity has been designed to meet the educational needs of he- Dr. Kanti Rai—Royalties: UpToDate; Other Honoraria: Bayer, Celgene, matologist and oncologists involved in the management of patients Cephalon, Genentech. with hematologic malignancies. Dr. S. Vincent Rajkumar: No real or apparent conflicts of interest. Statement of Need/Program Overview The following planners and managers, Linda Graham, RN, BSN, Data are emerging on novel agents as well as new combination regi- BA, Jan Hixon, RN, BSN, MA, Trace Hutchison, PharmD, mens for the treatment of hematologic malignancies. This mono- Julia Kirkwood, RN, BSN and Jan Schultz, RN, MSN, CCMEP graph reviews some of the salient new data recently presented at hereby state that they or their spouse/life partner do not have any international meetings of hematologists/oncologists. financial relationships or relationships to products or devices with any commercial interest related to the content of this activity of any Educational Objectives amount during the past 12 months. After completing this activity, the participant should be better able to: Jessica Wapner: No real or apparent conflicts of interest. • Describe how to integrate prognostic factors into treatment Method of Participation decisions for patients with hematologic malignancies, including There are no fees for participating and receiving CME credit for this lymphoma, leukemia, myelodysplastic syndromes (MDS), and activity. During the period February 2009 through February 15, 2010, multiple myeloma participants must 1) read the learning objectives and faculty disclosures; • Identify factors influencing the choice of treatment for patients 2) study the educational activity; 3) complete the posttest by recording with MDS and leukemia the best answer to each question in the answer key on the evaluation • Outline the most recent data on treatment options for both newly form; 4) complete the evaluation form; and 5) mail or fax the evalua- diagnosed and recurrent multiple myeloma. tion form with answer key to Postgraduate Institute for Medicine. You may also complete the post-test online at www.cmeuniversity.com. On Accreditation Statement the navigation menu, click on “Find Post-tests by Course” and search This activity has been planned and implemented in accordance by project ID 6188. Upon successfully completing the post-test and with the Essential Areas and policies of the Accreditation Council evaluation, your certificate will be made available immediately. for Continuing Medical Education (ACCME) through the joint sponsorship of Postgraduate Institute for Medicine (PIM) and A statement of credit will be issued only upon receipt of a complet- Millennium Medical Publishing, Inc. PIM is accredited by the AC- ed activity evaluation form and a completed posttest with a score of CME to provide continuing medical education for physicians. 70% or better. Your statement of credit will be mailed to you within three weeks. Credit Designation PIM designates this educational activity for a maximum of Media 1.25 /AMA PRA Category 1 Credit(s)TM/. Physicians should only Monograph claim credit commensurate with the extent of their participation in the activity. Disclosure of Unlabeled Use This educational activity may contain discussion of published and/or Disclosure of Conflicts of Interest investigational uses of agents that are not indicated by the FDA. PIM, PIM assesses conflict of interest with its instructors, planners, man- Millennium Medical Publishing, Inc., Cephalon, Inc., and Celgene agers and other individuals who are in a position to control the con- Corporation do not recommend the use of any agent outside of the tent of continuing medical education (CME) activities. All relevant labeled indications. conflicts of interest that are identified are thoroughly vetted by PIM for fair balance, scientific objectivity of studies utilized in this activ- The opinions expressed in the educational activity are those of the fac- ity, and patient care recommendations. PIM is committed to provid- ulty and do not necessarily represent the views of PIM, Millennium ing its learners with high quality CME activities and related materi- Medical Publishing, Inc., Cephalon, Inc., or Celgene Corporation. als that promote improvements or quality in healthcare and not a Please refer to the official prescribing information for each product for specific proprietary business interest of a commercial interest. discussion of approved indications, contraindications, and warnings. The faculty reported the following financial relationships or re- Disclaimer lationships to products or devices they or their spouse/life part- Participants have an implied responsibility to use the newly acquired ner have with commercial interests related to the content of this information to enhance patient outcomes and their own professional CME activity: development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medica- Dr. Bruce Cheson—Consulting fees: Celgene, Cephalon, Genentech, tions, or other courses of diagnosis or treatment discussed or suggested Millennium; Speakers’ Bureau: Genentech, Millennium in this activity should not be used by clinicians without evaluation of Dr. Shaji Kumar—Research support: Bayer, Celgene, Genzyme, their patient’s conditions and possible contraindications on dangers in Millennium use, review of any applicable manufacturer’s product information, and Dr. John Leonard—Consulting fees: Biogen IDEC, Celgene, Cepha- comparison with recommendations of other authorities. lon, Genentech, GlaxoSmithKline, Immunomedics, Johnson & Johnson, Millennium, Wyeth p R e S e n tatio n S R e vi e w Introduction eaders perusing the 2008 American Society tions with histone deacety- of Hematology (ASH) abstracts selected for lase inhibitors may further the accompanying review cannot help but be improve patient outcome. Rimpressed by not only how far we have come in the last Unfortunately, improvements few years in the treatment of patients with leukemias, in the therapy of acute mye- lymphomas and myeloma, but also how far there is to logenous leukemia have been go. The days of empiric mixing and matching of con- slow in coming. ventional cytotoxics, once the subject of many ASH The ASH meetings provided important data on the presentations, has been replaced by studies reporting role of both relatively standard agents as well as novel on a series of novel agents which, when demonstrated compounds in the non-Hodgkin
Load more

Recommended publications
  • Jackie Takes a Walk
    /C /Z minutes — does have problems. They start even before the narrative begins. The top name on the acknowledgment list, spelled as "Barry" McPherson, special counsel to President Johnson, should be "Harry." The geography of the White House is loused up, with the Oval Office in the East Jackie Takes Wing and the press secretary's'office over- looking the Rose Garden. There are a few political errors of judge- 1 ment. Sen. Birch Bayh, one of the men a Walk who helped save Edward Kennedy when his plane crashed in the early '60s and a Jane Perlez Viking, since promoted to editor, Rebecca longtime Kennedy ally, is depicted as a Singleton, sees it. "Quitting the way she possible conspirator in the assassination Jackie Onassis, the publishing in- did wasn't a particularly classy thing to plot. So is Sen. Robert Byrd. Hubert dustry's most famous editor, seems to do. Humphrey is described as being a have a problem with books she doesn't "She never said anything about the Democratic kingmaker in 1981. read. book. From the time she came, Tom was First there was the William Manchester Shall We Tell . spans seven days of so consistently protective of her special plot action. In addition, there is the affair 10 years ago, when, the former First situation. She didn't tell Tom herself she Lady decided that a finely-researched ac- Inauguration chapter in which President was going to do it [quit]. There was no Ted Kennedy, wrapped in a bathtowel on count of JFK to which she had contributed personal discussion of the incident itself.
    [Show full text]
  • A Music Critic on His First Love, Which Was Reading
    them over, and get its mitts on record distribution in the bargain. Nor is it all about the Benjamins. If by popular music you mean domestic palliatives from “Home Sweet to Celine Dion, OK, that’s another realm. But most of what’s now played in concert halls and honored at the Kennedy Center has its roots in antisocial impulses—in a carpe diem hedonism that is a way of life for violent men with money to burn who know damn well they’re destined for prison or the morgue. Most music books assume or briefly acknowledge these inconvenient facts when they don’t ignore them altogether. But they’re central to two recent histories and two recent memoirs, all highly recommended. Memphis-based Preston Lauterbach’s The Chitlin’ Circuit and the Roots of Rock ’n’ Roll For anyone who cares about the history of pop—and also, in a better world, anyone relishes the criminal origins of a mostly southern black club scene from the early ’30s to who cares about the history of the avant-garde—Between Montmartre and the Mudd the late ’60s. Journalist-bizzer Dan Charnas’s history of the hip-hop industry, The Big has a big story to tell. Popular music is generally identified with the rise of Payback, steers clear of much small-timeClub thuggery and leaves brutal LA label boss Suge Knight to Ronin Ro’s Have Gun, Willsong Travel, publishing butROBERT plenty and of piano crime manufacture stories rise up inas theprofits mid-nineteenth century. But starting snowball. Ice-T’s Ice devotes twenty-fivein the 1880s, steely artists pages toand the other lucrative fringe-dwelling heisting operation weirdos have been active as pop the rapper-actor ran before he madeperformers, music his composers, job.
    [Show full text]
  • Author Biography Toni Morrison Discussion Guide
    TONI MORRISON DISCUSSION GUIDE (630) 232-0780 [email protected] AUTHOR BIOGRAPHY The second of the four children of George and Ramah (Willis) Wofford, Toni Morrison was born Chloe Anthony Wofford in Lorain, Ohio, a steel town twenty-five miles west of Cleveland. During the worst years of the Great Depression, her father worked as a car washer, a welder in a local steel mill, and road-construction worker, while her mother, a feisty, determined woman, dealt with callous landlords and impertinent social workers. "When an eviction notice was put on our house, she tore it off," Morrison remembered, as quoted in People. "If there were maggots in our flour, she wrote a letter to [President] Franklin Roosevelt. My mother believed something should be done about inhuman situations." In an article for the New York Times Magazine, Morrison discussed her parents' contrasting attitudes toward white society and the effect of those conflicting views on her own perception of the quality of black life in America. Ramah Wofford believed that, in time, race relations would improve; George Wofford distrusted "every word and every gesture of every white man on Earth." Both parents were convinced, however, that "all succor and aid came from themselves and their neighborhood." Consequently, Morrison, although she attended a multiracial school, was raised in "a basically racist household" and grew up "with more than a child's contempt for white people." After graduating with honors from high school in 1949, Toni Morrison enrolled at Howard University in Washington, DC. Morrison devoted most of her free time to the Howard University Players, a campus theater company she described as "a place where hard work, thought, and talent" were praised and "merit was the only rank." She often appeared in campus productions, and in the summers she traveled throughout the South with a repertory troupe made up of faculty members and students.
    [Show full text]
  • Business Pass Info Packet 2019 4.22
    Full-Access Business Pass Information For writers interested in taking their work to market one day, Lit Fest offers an opportunity to educate yourself about and connect with publishing professionals. Given the busy schedules of agents and editors, it’s a rare chance to receive their direct feedback and advice. You must purchase a Gold, Silver, Bronze, Penny, or Full-Access Business Pass before requesting a meeting with an agent. Thanks to Aevitas Creative Management for their Full Access Business Pass Sponsorship for a writer of color. We have the following agents and editors available for one-on-one meetings at Lit Fest 2021*: Friday Saturday Sunday Monday Tuesday Wednesday Thursday June 4 June 5 June 6 June 7 June 8 June 9 June 10 Lisa Paloma Paloma Danya Sarah Fuentes Sarah Fuentes Jamie Carr Gallagher Hernando Hernando Kukafka Malaga Sue Park Sue Park John Maas Danya Serene Hakim Serene Hakim Baldi Kukafka Angeline Angeline John Maas John Maas Rodriguez Rodriguez Malaga Baldi Malaga Baldi Tanusri Chris Parris- Chris Parris- Prasanna Lamb Lamb Matt Martz Tanusri Julie Buntin Prasanna Matt Martz June 11 June 12 June 13 Jamie Carr Eric Smith Eric Smith Serene Hakim Julie Buntin *Schedule is subject to change. LIT FEST PASSHOLDERS BEFORE MEETING WITH AN AGENT OR EDITOR Make sure you’re really ready for this. Writing is a competitive business, and agents are direct about their reactions to your work. Have you had a professional read of the work you’re submitting? Is it reasonably edited? If not, we’d recommend attending Lit Fest’s business panels first and then reaching out to agents and editors at a later date.
    [Show full text]
  • World Literature Reading List
    WEST BLOOMFIELD HIGH SCHOOL ENGLISH DEPARTMENT Eleventh Grade Honors World Literature Hello! Welcome to Honors World Literature. We get to spend the year exploring how literature and theater evolved over time, all while exploring the universality of the human experience through time and space. I could not be more excited to take this journey with you! Please do not hesitate to email me should you want any help picking out a book or two to read. There is almost nothing I love more than talking about books! Summer Reading Assignment 2020: Please read two books during the summer. Step #1 Read Homegoing by Yaa Gyasi Winner of the PEN/ Hemingway Award Winner of the NBCC's John Leonard Award Shortlisted for the British Book Award - Debut of the Year A New York Times Notable Book A Washington Post Notable Book One of the Best Books of the Year: NPR, Time, Oprah.com, Harper’s Bazaar, San Francisco Chronicle, Mother Jones, Esquire, Elle, Paste, Entertainment Weekly, the Skimm, PopSugar, Minneapolis Star Tribune, BuzzFeed, The Guardian, Financial Times Ghana, eighteenth century: two half-sisters are born into different villages, each unaware of the other. One will marry an Englishman and lead a life of comfort in the palatial rooms of the Cape Coast Castle. The other will be captured in a raid on her village, imprisoned in the very same castle, and sold into slavery. Homegoing follows the parallel paths of these sisters and their descendants through eight generations: from the Gold Coast to the plantations of Mississippi, from the American Civil War to Jazz Age Harlem.
    [Show full text]
  • Music in Thomas Pynchon's Mason & Dixon
    ISSN: 2044-4095 Author(s): John Joseph Hess Affiliation(s): Independent Researcher Title: Music in Thomas Pynchon’s Mason & Dixon Date: 2014 Volume: 2 Issue: 2 URL: https://www.pynchon.net/owap/article/view/75 DOI: http://dx.doi.org/10.7766/orbit.v2.2.75 Abstract: Through Pynchon-written songs, integration of Italian opera, instances of harmonic performance, dialogue with Plato’s Republic and Benjamin Franklin’s glass armonica performance, Mason & Dixon extends, elaborates, and investigates Pynchon’s own standard musical practices. Pynchon’s investigation of the domestic, political, and theoretical dimensions of musical harmony in colonial America provides the focus for the novel’s historical, political, and aesthetic critique. Extending Pynchon’s career-long engagement with musical forms and cultures to unique levels of philosophical abstraction, in Mason & Dixon’s consideration of the “inherent Vice” of harmony, Pynchon ultimately criticizes the tendency in his own fiction for characters and narrators to conceive of music in terms that rely on the tenuous and affective communal potentials of harmony. Music in Thomas Pynchon’s Mason & Dixon John Joseph Hess Few readers of Thomas Pynchon would dispute William Vesterman’s claim that “poems and particularly songs, make up a characteristic part of Pynchon’s work: without them a reader’s experience would not be at 1 all the same.” While Vesterman was specifically interested in Pynchon’s poetic practice, Pynchon’s fifty year career as a novelist involves a sustained engagement with a range of musical effects. Music is a formal feature with thematic significance in Pynchon’s early short fiction and in every novel from V.
    [Show full text]
  • The Bluest Eye / by Toni Morrison
    acclaim for Toni Morrison “[Toni Morrison] may be the last classic American writer, squarely in the tradition of Poe, Melville, Twain and Faulkner.” —Newsweek “In the first ranks of our living novelists.” —St. Louis Post-Dispatch “Toni Morrison is not just an important contemporary novelist but a major figure in our national literature.” —The New York Review of Books “She is the best writer in America.” —John Leonard, National Public Radio “[Toni Morrison] has moved from strength to strength until she has reached the distinction of being beyond comparison.” —Entertainment Weekly “Morrison is one of the most exciting living American writers.” —The Kansas City Star The Bluest Eye “Toni Morrison has made herself into the D. H. Lawrence of the black psyche, transforming individuals into forces, idio- syncrasy into inevitability.” —New York “Morrison is perhaps the finest novelist of our time.” —Vogue “Toni Morrison is one of the finest writers in America today.” —Louisville Courier-Journal Toni Morrison The Bluest Eye Toni Morrison is the Robert F. Goheen Professor of Humani- ties, Emeritus at Princeton University. She has received the National Book Critics Circle Award and the Pulitzer Prize. In 1993 she was awarded the Nobel Prize in Literature. She lives in Rockland County, New York, and Princeton, New Jersey. also by toni morrison fiction Love Paradise Jazz Beloved Tar Baby Song of Solomon Sula nonfiction The Dancing Mind Playing in the Dark: Whiteness and the Literary Imagination L THE BLUEST EYE L a novel Toni Morrison vintage international Vintage Books A Division of Random House, Inc. New York FIRST VINTAGE INTERNATIONAL EDITION, MAY 2007 Copyright © 1970, copyright renewed 1998 by Toni Morrison Foreword © 1993, 2007 by Toni Morrison All rights reserved.
    [Show full text]
  • A Spatial Reading of Pynchon's California Trilogy
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Archivio della ricerca- Università di Roma La Sapienza “The Map is Not the Territory”: A Spatial Reading of Pynchon’s California Trilogy Department of European, American and Intercultural Studies Ph.D. Program in English-language Literatures Candidate: Ali Dehdarirad Supervisor: Prof. Giorgio Mariani Anno Accademico 2019-2020 Contents Acknowledgements iii Abbreviations iv Introduction 1 Chapter One The Crying of Lot 49 9 1. Introduction: 1.1. From the Fifties to the Sixties: A Critical Moment of Change 1.2. In the Midst of a Long Decade: The American Sixties after Kennedy 14 1.3. The Counterculture as Socio-cultural Reaction to the Politics of the Sixties 18 1.4. The Sixties in Pynchon’s Works 22 2. Inside The Crying of Lot 49: Toward a Geocritical Understanding 28 SECTION 1 30 2.1. The Spatial Dimension in Pynchon’s Early Life and Career 2.2. From Pynchon’s San Narciso to California’s Orange County 34 2.2.1. Creating San Narciso: Understanding the “postmetropolitan transition” 35 2.2.2. A Historical Analogy between San Narciso and Orange County 39 2.2.3. Reading Pynchon’s San Narciso through Geocritical Lenses: Understanding The Crying of Lot 49’s Narrative Structure through Fictional and Political Spaces 41 SECTION 2 45 2.3. An Analysis of Thirdspace in Pynchon’s Fiction 2.3.1. An Attempt at Reading Pynchon’s San Narciso through Thirdspace: The Search for an Alternative Reality in The Crying of Lot 49 47 Chapter Two Vineland 54 1.
    [Show full text]
  • Accounting with Honor
    RED, GERALD OAK JR N. VIETNAM O2 1966/12/11 SEATTLE, WA • USA BB ALGAARD, HAROLD LOWELL N. VIETNAM W1 1971/03/04 FOSSTON, MN • USA XX ALLARD, RICHARD MICHAEL S. VIETNAM E4 1967/08/24 CHESANING, MI COTT, KS • USAF XX ALLINSON, DAVID JAY N. VIETNAM O3 1966/08/12 HELENA, MT • USAF BB ALLOWAY, CLYDE DOUGLAS S. VIETNAM E5 1970/06/07 PORTSMOUTH, NH • USMC BB ALM, RICHARD ANDREW N. VIETNAM O4 971/11/23 SHERIDAN, OR • USMC XX ALWAN, HAROLD JOSEPH S. VIETNAM O4 1967/02/27 PEORIA, IL • USAF BB ANDERSON, GREGORY LEE LAOS E4 1970/01/28 WHEATON, IL • USMC BB ANDERSON, THOMAS EDWARD S. VIETNAM S. VIETNAM O4 1966/03/04 STAMFORD, CT • USA BB ANGELL, MARSHALL JOSEPH S. VIETNAM E5 1963/12/12 ROANOKE, VA • USAF XX ANGSTADT, RALPH HAROLD N. VIETNAM O4 1966/10/18 FLEETWOOD, PA • USA BB ANSPACH, RMITSTEAD, STEVEN RAY LAOS O2 1969/03/17 LOS ANGELES, CA • USAF BB ARMOND, ROBERT LAURENCE S. VIETNAM O3 1965/06/18 SAN MATEO, CA • USAF BB ARMSTRONG, FRANK ALTON III LAOS O4 1967/10/06 SHREVEPORT, L INGS, MT • USN BB ASHBY, DONALD ROBERTS SR S. VIETNAM O4 1967/01/19 NEWPORT NEWS, VA • USMC XX ASHLOCK, CARLOS S. VIETNAM E4 1967/05/12 PHILADELPHIA, PA • USN BB ASMUSSEN, GLENN EDWARD S. VIETNAM ID N. VIETNAM O2 1967/04/24 NEW CANAAN, CT • USN XX AUSTIN, ELLIS ERNEST N. VIETNAM O4 1966/04/21 VERMONTVILLE, MI • USAF XX AUSTIN, JOSEPH CLAIR N. VIETNAM O5 1967/03/19 MOUNDSVILLE, WV • USA BB AUX- W, NY • USN BB AVORE, MALCOLM ARTHUR S.
    [Show full text]
  • Bookforum | Summer 2005 9/29/10 7:27 AM
    Bookforum | Summer 2005 9/29/10 7:27 AM Don DeLillo It was as though, in some odd quantum stroke, Hemingway died one day and Pynchon was born the next. One literature bends into another. Pynchon has made American writing a broader and stronger force. He found whispers and apparitions at the edge of modern awareness but did not lessen our sense of the physicality of American prose, the shotgun vigor, the street humor, the body fluids, the put-on. I was writing ads for Sears truck tires when a friend gave me a copy of V. in paperback. I read it and thought, Where did this come from? The scale of his work, large in geography and unafraid of major subjects, helped us locate our fiction not only in small anonymous corners, human and ever-essential, but out there as well, in the sprawl of high imagination and collective dreams. Don DeLillo's most recent novel is Cosmopolis (Scribner, 2003). In 1973, Thomas Pynchon's Gravity's Rainbow landed on my brain and exploded there like, well, a V-2 rocket. It was precisely the book I needed at the time, which tells you something about my mental and spiritual condition. Hey, it was the '70s. The country was Jeffrey Eugenides I have a coffee cup in storage in low in the water and so was I. Tar-black humor, crushing difficulty, rampant paranoia, Berlin. It bears a fetching image of a V-2 rocket and the accelerating entropy, jaw-dropping perversity, apocalyptic terror, history as a conspiracy name of the touristic locale in Germany where I bought it: of the conjoined forces of technology, death, and sinister Control—it was all good.
    [Show full text]
  • Catholic Imagination Conference Program
    Connecting, Researching, Communicating THE THIRD BIENNIAL The Joan and Bill Hank Center CATHOLIC IMAGINATION CONFERENCE Cfor the Catholic CIH Intellectual Heritage THE FUTURE OF THE CATHOLIC LITERARY TRADITION www.luc.edu/ccih/ Loyola University Chicago | September 19-21, 2019 FALL 2019 LAKE SHORE CAMPUS CAMPION HALL WEST LOYOLA AVENUE CROWN MERTZ SeanSean Earl Earl Field Field CENTER HALL Alfie Norville Practice Facility CUDAHY CTA NORVILLE LIBRARY RED LINE GENTILE ATHLETICS LOYOLA ARENA CENTER STATION DAMEN DUMBACH STUDENT HALL CENTER LOYOLA INFORMATION COMMONS Entrance to Fordham parking East Quad CUDAHY HALAS SCIENCE HALL SPORTS MADONNA DELLA FORDHAM West CENTER STRADA CHAPEL HALL Quad P UNIVERSITY BOOKSTORE NORTH SHERIDAN ROAD NORTH SHERIDAN GRANADA CUNEO CENTER HALL CAMPUS SAFETY OFFICE COFFEY HALL P MUNDELEIN QUINLAN LIFE CENTER SCIENCES SHUTTLE PIPER CENTER HALL STOP FLANNER HALL WELCOME CENTER DEVON AVENUE WEST SHERIDAN ROAD RALPH BVM HALL ARNOLD SULLIVAN FINE ARTS DE NOBILI CENTER FOR ANNEX HALL STUDENT SERVICES REGIS INSTITUTE OF HALL SIMPSON ENVIRONMENTAL LIVING- SUSTAINABILITY LEARNING CENTER NORTH SHERIDAN ROAD NORTH SHERIDAN NORTH KENMORE AVENUE NORTH WINTHROP AVENUE NORTH BROADWAY STREET NORTH BROADWAY ALUMNI HOUSE 1 Welcome Conference Attendees: A warm welcome to the Third Biennial Catholic Imagination Conference. In 2015, we inaugurated this unique conference in lovely Los Angeles; in 2017, we assembled in beautiful New York City for an inspired second iter- ation; today, we bring the conference to sweet home Chicago—the city of Big Shoulders, quick wit, and a robust Catholic culture. Our conference features over 80 writers, poets, filmmakers, playwrights, journalists, editors, publishers, stu- dents, and critics who will explore a variety of questions surrounding the Catholic imagination in literature and the arts.
    [Show full text]
  • The Story of Captain John Leonard's Fascination with Military Band Organs Captain John Leonard
    Carousel Organ, Issue No. 4 — July, 2000 The Story of Captain John Leonard's Fascination with Military Band Organs Captain John Leonard I grew up in Toronto, Ontario, Canada, and my family vaca- that it would. I think Reed was one of the very first to use tioned at Toronto Island, just south of Toronto, an important recorded music on his carousel. About 1939 he got the organ shipping port on Lake Ontario. Hanlan's Point, one of the three repaired by Eatons, a large department store in Toronto. I don't sections of the island, boasted of a large amusement park in the know what they did, but the organ finally played again. 1890s. The island was a major tourist area. Unfortunately, Reed decided not to use the organ, even though Naturally, there was a carousel with a band organ. I recall it worked. I remember how sad I was that he wouldn't use the riding to the park on my bicycle and listening to the organ. I organ. don't remember any of the tunes, but remember the banging of There is a sequel to this story. About 1957 the city of Toronto the beater hitting the big bass drum and cymbal. The carousel decided to rejuvenate the park. The carousel and building were rounding boards had pretty scenes painted on them. One of the dismantled. They sold the carousel and organ to Eatons. I tried boards had the words “Herschell Spillman & Co., North to locate the organ, but was not successful. They sent me on a Tonawanda New York, USA Builders.” The carousel was a wild goose chase, but I had no luck at all.
    [Show full text]