PLoS Biology our flagship title * 2.4 million pages fully downloaded per year * 1.5 million visits per year * 100,000 unique visitors per month

Media Kit 2006-2007 www.PLoS.org table OF CONTENTS

1 LETTER FROM THE PUBLISHER

2 A LITTLE HISTORY

3 EXPANDED ADVERTISING OPPORTUNITIES

4 HEADLINE FACTS AND FIGURES

5 COOL ACCOLADES

6 RATES & SPONSORSHIP PACKAGES

7 PREMIUM AD TYPES

8 TECHNICAL SPECIFICATIONS

9 CLOSING DATES

10 GENERAL INFORMATION

PLoS Media Kit 2006-2007 i advertise@plos.org (415) 568 3446 1a 1b 1c

letter from the publisher redesigned web sites give advertisers more choice and impact

Dear PLoS Advertiser,

Welcome to PLoS. As a premier open access publisher, our journals have rapidly become “must reads” for the world’s most innovative minds.

Infl uential researchers throughout the world choose PLoS because they know that scientifi c progress occurs faster when results are freely accessible to all. This is what makes them ardent fans of open access and compels them to publish their work in PLoS journals.

The PLoS fl agship journals, PLoS Biology and PLoS Medicine, are already established as top-tier publications with impact factors of 14.7 and 8.4, respectively. All our newer titles have also quickly gained prominence amongst the leaders in their fi elds. Later in 2006, we will launching PLoS ONE, another groundbreaking publishing initiative.

By advertising with PLoS, your products and services will reach well-connected and successful individuals with the purchasing power and authority to give your brand power. Plus, you will also be associating your name with a positive force for change and the most exciting projects in scientifi c and medical publishing.

As you read through this media kit, you will discover the new opportunities that PLoS has introduced to give advertisers more choice, greater reach, and a solid return on your advertising spend.

I look forward to seeing you online.

Best regards,

Mark Patterson Director of Publishing

PLoS Media Kit 2006-2007 1 [email protected] (415) 568 3446 2a 2b 2c

a little history

Change Advocate journals, and we appreciate their participation. They The PLoS story began in 2000. Its fi rst success advertise with PLoS because they can reach a broad came when 34,000 scientists signed an open letter global audience that includes research scientists from PLoS to the traditional scientifi c and medical at the largest and most well-known laboratories, publishers stating their belief that the results of universities, and institutes in the world plus, publicly-funded research should be a publicly- opinion leaders, educators, and the general public. available resource. Naturally, PLoS’s paradigm-shifting ideas particularly This view is now shared by many leading fi gures in resonate with tomorrow’s thought leaders - this science and medicine. For example in 2004, 25 Nobel younger crowd are eagerly awaiting the launch of Prize winners, including James Watson (who together PLoS ONE, an interactive open access online forum with Francis Crick discovered the structure of the for the very rapid publication of primary research in DNA molecule in the 1950’s) and Harold Varmus all areas of science and medicine. Early signs show (a founder of PLoS), petitioned the US Congress that PLoS ONE will be a great success with these to allow public access to publicly-funded research researchers, who are enthusiastic about sharing publications. information via the Internet.

The other founders of PLoS, Pat Brown and Mike With the continued growth and development of our Eisen, joined Harold Varmus to form a non-profi t innovative and high-quality open access publishing publishing and advocacy organization to turn this portfolio, PLoS will remain at the forefront of a vision into reality. revolution in the communication and dissemination of scientifi c and medical research. Quality Publisher In 2003, PLoS launched its fi rst peer-reviewed freely accessible online title, PLoS Biology, to show that high-quality journals could be published this way. The world now knows this as open access publishing. If I could do it over Today, PLoS Biology and PLoS Medicine are ranked in again, I’d publish that the top tier of life-science journals with impressive impact factors of 14.7 and 8.4 respectively, and they paper in PLoS Biology.” are the fl agships for a group that includes another four (and soon to be fi ve) groundbreaking titles. “– Dr. James D. Watson, Nobel Laureate Advertiser’s Choice (pictured above) Many suppliers to the life-science market have supported the PLoS mission by advertising in the

PLoS Media Kit 2006-2007 2 [email protected] (415) 568 3446 3a 3b 3c

expanded advertising opportunities

With the expansion of our publishing 2 operation and the forthcoming launch of PLoS ONE (which is expected to drive more traffi c to our other sites), PLoS is currently redesigning its entire range of titles. They will be unveiled in Fall 2006 and will feature many new advertising opportunities.

1

SKYSCRAPER, HALF SKYSCRAPER choose the size that fi ts your communication needs and budget

3

BANNERS horizontal messaging opportunities on each journal home page

OPT-IN CONTENT ALERT EMAILS now with two positions above the journal banner. Circulation is constantly rising, so check for the latest numbers.

PLoS Media Kit 2006-2007 3 [email protected] (415) 568 3446 4a 4b 4c

headline facts and figures

By advertising with PLoS, not only will your company benefi t from the impressive exposure that PLoS journals provide, you will also be associating your name with a positive force for change and the most exciting projects in scientifi c and medical publishing.

PLoS Biology:

nearly 2.37 1.49 100,000 MILLION MILLION unique visitors pages downloaded visits

PLoS Medicine:

nearly 1.49 1 70,000 MILLION MILLION unique visitors pages downloaded visits

Opted-in Content Alert Emails: Nearly 100,000 are sent out EACH MONTH

Notes: All circulation fi gures cover the time period July 05-June 06, Unique visitors are for April 06 Medicine and May 06 Biology. Naturally many scientists sign up for multiple alerts. Please send a note to [email protected] for the latest numbers because they are constantly rising.

PLoS tracks pages downloaded as opposed to hits because they are the fairest measure of usage. A page can take many hits to download, especially if it contains many graphic fi les. Our statistics comply with COUNTER (www.projectcounter.org), which only counts pages once they are fully downloaded.

PLoS Media Kit 2006-2007 4 [email protected] (415) 568 3446 5a 5b 5c

cool accolades along the way, we’ve won some cool awards and received some inspirational words of encouragement

Here’s what Le Monde said about PLoS in November 2005: One of our favorite quotes is from a school The Public Library of Science, an open- teacher in Berkeley, CA who said: access collection of scientifi c journals, is beginning to reach the same level of Dear Public Library of Science people, recognition as authoritative publications such as Nature and Science.” I just listened to a mouse song online and I wanted to tell you how grateful I am for “ your journal. PLoS was also named as a winner in Scientifi c I am a middle school science teacher. I do not American’s Top 50 for 2005 for helping to redress the balance between openness in research and the protections have the funds to subscribe to the traditional that commercialization requires: science journals. Tomorrow my students will hear the same mouse song I listened to Individuals and companies have launched and I am sure they will be as enchanted and initiatives recently that enhance open access interested as I am. in many welcome ways. Patrick O. Brown and Michael B. Eisen (the founders of PLoS I can assure you that the availability of together with Harold Varmus) have served research papers will benefi t the future of as effective champions for the burgeoning scientifi c research by providing motivation and “ open access movement in fundamental stimulation for millions of fl edgling scientists. research.”

Sincerely, When PLoS Medicine was launched in 2004, the British Barbara Stebbins Medical Journal said: Science Teacher Black Pine Circle School ...its fascinating variety of commentary, Berkeley, CA, USA essays and original research is about as good as it gets for a global medical journal.”

In 2004, PLoS won the Wired Rave Award for“ “Cracking the spine of the science cartel”.

PLoS Media Kit 2006-2007 5 [email protected] (415) 568 3446 6a 6b 6c

rates online advertising rates 2006-2007 all prices are CPM - 50,000 impression minimum PLoS Biology. All other sites 30,000.

PLoS Biology SIZES Homepage Table of Contents Top 10 Articles New Articles Browse by Subject 468 x 60 Banner $20 $15 $20 $15 $20 120 x 600 Skyscraper $40 n/a n/a n/a $40

120 x 240 Vertical Banner $20 n/a n/a n/a n/a

600 x 60 Banner $40 n/a n/a n/a n/a (opt-in email subscribers)

PLoS Medicine SIZES Homepage Table of Contents Top 10 Articles New Articles Browse by Subject 468 x 60 Banner $10 $8 $10 $8 $10 120 x 600 Skyscraper $20 n/a n/a n/a $20

120 x 240 Vertical Banner $10 n/a n/a n/a n/a

600 x 60 Banner $20 n/a n/a n/a n/a (opt-in email subscribers)

Rates for PLoS Computational Biology, PLoS Genetics, PLoS Pathogens, PLoS Clinical Trials, and PLoS ONE are available by request.

sponsorship packages Special opportunities are available on all our titles. It is possible to be the exclusive sponsor on any of the fully downloadable PDF issues (inside front cover and back cover positions are available). This deal also allows advertisers to secure a skyscraper on the site for one year (non-exclusive) and a banner on the email table of contents for one year (non-exclusive), top position guaranteed. Please send a note to [email protected] for further information.

PLoS Media Kit 2006-2007 6 [email protected] (415) 568 3446 7a 7b 7c

premium ad types 120 pixels EXAMPLE Journal Homepages 468 pixels 2

Banner (72 dpi)

60 pixels 1 EXAMPLE Skyscraper Ad (72 dpi)

120 pixels EXAMPLE 600 pixels

Vertical Banner (72 dpi) 240 pixels

3

Email Content Alerts 600 pixels

ADVERTISEMENT

Horizontal Banner (72 dpi) 75 pixels 60 pixels

EXAMPLE ADVERTISEMENT

PLoS Media Kit 2006-2007 7 [email protected] (415) 568 3446 8a 8b 8c

technical specifi cations

PLoS Journal Websites AD UNIT Exact Dimensions GIF, JPEG File Weight Flash File Weight (1) Banner 468 x 60 pixels 20k max 30k max (2) Skyscraper 120 x 600 pixels 20k max 30k max (3) Vertical Banner 120 x 240 pixels 20k max 30k max

Opt-in Email Content Alerts AD UNIT Exact Dimensions GIF, JPEG File Weight Flash File Weight

Horizontal Banner 600 x 60 pixels 20k max n/a (for PLoS Email Alerts)

Ad Requirements Additional Requirements for Flash Ads Color Mode RGB Available for homepage banner, vertical Available banner and skyscraper slots. Not available on Locations Alternative Text 30 characters maximum Email Alerts slot.

Short “tagline” style phrase File Format Macromedia Flash 6 Compatible SWF File (max: 60 characters including spaces) Mouse-over Text Animation should last no longer than 15 seconds that displays when a user hovers the Animation mouse over the image and should not be set to loop

One URL only, must be domain name Audio No audio is permitted based and cannot be the IP address Clickthrough URL (i.e., www.google.com rather than Frame Rate 18 frames per second maximum http://207.123.476.78) A backup GIF fi le is required for non-fl ash users, Backup Gif following the fi le spec guidelines for GIF fi les Use a transparent click layer button needs to be added on the topmost layer of the Flash fi le. Flash Attach this command to the button: Clickthrough Commands on (release) { getURL (clickTAG); }

PLoS Media Kit 2006-2007 8 [email protected] (415) 568 3446 9a 9b 9c

closing dates

2007 ad closing dates for PLoS journals

PLoS Biology JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC

Insertion Orders Deadline 5-Dec 5-Jan 1-Feb 9-Mar 2-Apr 3-May 7-Jun 6-Jul 7-Aug 7-Sep 5-Oct 8-Nov

eToC & Homepage Ad 19-Dec 23-Jan 20-Feb 27-Mar 24-Apr 22-May 26-Jun 24-Jul 22-Aug 25-Sep 23-Oct 27-Nov Materials to Marketing

eToC Blasts/Issue goes 16-Jan 13-Feb 13-Mar 17-Apr 15-May 12-Jun 17-Jul 14-Aug 18-Sep 16-Oct 13-Nov 18-Dec live online

PLoS Medicine JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC

Insertion Orders Deadline 19-Dec 16-Jan 13-Feb 13-Mar 17-Apr 15-May 19-Jun 17-Jul 14-Aug 18-Sep 16-Oct 13-Nov

eToC & Homepage Ad 2-Jan 30-Jan 27-Feb 27-Mar 1-May 29-May 3-Jul 31-Jul 28-Aug 2-Oct 30-Oct 27-Nov Materials to Marketing

eToC Blasts/Issue goes 30-Jan 27-Feb 27-Mar 24-Apr 29-May 26-Jun 31-Jul 28- Aug 25-Sep 30-Oct 27-Nov 25-Dec live online

PLoS Computational Biology, PLoS Genetics, PLoS Pathogens, and PLoS Clinical Trials JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC

Insertion Orders Deadline 15-Dec 12-Jan 16-Feb 16-Mar 13-Apr 18-May 15-Jun 20-Jul 17-Aug 14-Sep 19-Oct 16-Nov

eToC & Homepage Ad 29-Dec 26-Jan 2-Mar 30-Mar 27-Apr 1-Jun 29-Jun 3-Aug 31-Aug 28-Sep 2-Nov 30-Nov Materials to Marketing

eToC Blasts/Issue goes 26-Jan 23-Feb 30-Mar 27-Apr 25-May 29-Jun 27-Jul 31-Aug 28-Sep 26-Oct 30-Nov 28-Dec live online

(Note: eToC stands for Email Table of Contents)

PLoS Media Kit 2006-2007 9 [email protected] (415) 568 3446 general information

Requirements for Acceptance of Advertising All advertising is subject to the publisher’s ADVERTISING INQUIRIES: approval. PLoS Medicine and PLoS Clinical Trials do not accept advertising for pharmaceutical Patric Donaghy PLoS Account Executive products or medical devices. The advertiser and/ Phone: (415) 564-8612 or its advertising agency agrees to indemnify and Fax: (415) 665-4579 hold harmless Public Library of Science and its Email: [email protected] employees and agents for any liability and costs, including but not limited to reasonable attorney’s Allison Hawxhurst fees incurred in connection with any third-party Advertising Coordinator claim arising out of the appearance of the ad. Phone: (415) 624-1223 Public Library of Science reserves the right to Fax: (415) 546-4090 remove any ad which is inaccurate, misleading, E-mail: [email protected] defamatory, or otherwise contrary to the rights of Public Library of Science or third parties.

Terms of Payment All terms, net 30 days from receipt of invoice. Cancellation of advertising must be in writing. Advertisers are liable for payment for insertions canceled after materials close (based on date of receipt of written notice by publisher). Advertisers canceling contracts will be invoiced at earned rate for space already used. The publisher reserves the right to pass through charges for additional preparation, typesetting, etc. that may be required.

Agency Discount The recognized agency discount is 15% when paid within 60 days of invoice date. The advertiser is responsible for expenses incurred to collect delinquent accounts.

PLoS Media Kit 2006-2007 10 [email protected] (415) 568 3446 photo credits

(1a) Image from Meyer et al. PLoS Biology 3(12): e422. (1b) Image from Frevert et al. PLoS Biology 3(6): e192. (1c) Image from Drake. PLoS Biology 3(7): e222, created by Paul Hebert.

(2a) Photo by Miriam Chua, courtesy of Cold Spring Harbor Laboratory Archives. (2b) Image from Melcher et al. PLoS Biology 3(9): e305. (2c) Image from Hanski et al. PLoS Biology 4(5): e305, created by Niclas Fritzén.

(3a) Image from Huh et al. PLoS Biology 2(1): e15, created by Jun R. Huh with additional photo manipulation by John Heisch. (3b) Image from Kiernan et al. PLoS Genetics 2(1): e4, created by Amy Kiernan.

(4a) Image from Pasini et al. PLoS Biology 4(7): e225, created by Sébastien Darras (4b) Image from McDermott et al. PLoS Biology 4(3): e51. (4c) Image from Carter et al. PLoS Medicine 2(3): e46.

(5a) Image from Kern et al. PLoS Biology 3(6): e209. (5b) Image from Cherry et al. PLoS Biology 3(5): e145, created by Doug Loewenthal. (5c) Image from Zhang et al. PLoS Computational Biology 1(6): e62.

(6a) Image from Sutherland et al. PLoS Medicine 2(4): e92. (6b) Image from Gross. PLoS Biology 3(6): e202, created by Frans de Waal. (6c) Image from Ferree et al. PLoS Pathogens 1(2): e14, created by Horacio M. Frydman and Eric Wieschaus.

(7a) Image from Tekaia et al. PLoS Computational Biology 1(7): e75, created by Simon Woodside and Edouard Yeramian. (7b) Image from Hu et al. PLoS Pathogens 2(2): e13. (7c) Image from Gross. PLoS Biology 3(9): e333.

(8a) Image from Gutierrez et al and Jain et al. PLoS Pathogens 1(1): e5 and e2, created by Sapna Khandwala. (8b) Image from Gross. PLoS Biology 4(8): e270. (8c) Image from Gross. PLoS Biology 4(8): e281.

(9a) Image from Capel et al. PLoS Biology 4(6): e187, created by Yuna Kim. (9b) Image from Hammond et al. PLoS Biology 2 (9): e248, created by Christian Konig. (9c) All My Memory © 2005 W. C. Burgard,. PLoS Medicine 2(1).

PLoS Media Kit 2006-2007 11 [email protected] (415) 568 3446