August 4, 2020 u vol. 117 u no. 31

From the Cover

18574 Green coloration in frogs 18292 Pencil-and-paper electronics on skin 18359 Inca resettlement in southern Peru 18591 Metformin and neurodegenerative disease 18832 Immune signaling activation in plants

Contents

THIS WEEK IN PNAS Cover image: Pictured is the frog 18131 In This Issue Espadarana callistomma. Carlos Taboada et al. report that green EDITORIAL coloration in frogs and toads results from proteins called biliverdin-binding 18135 Scientific versus public debates: A PNAS case study serpins, which bind to the pigment Douglas S. Massey and Mary C. Waters biliverdin and modify the pigment’s absorption properties. The coloration OPINION—Leading scientists discuss current issues mechanism evolved multiple times in 18137 At a Crossroads: Reimagining science, engineering, and medicine—and evolutionary history, and the findings its practitioners highlight the role of extracellular Freeman A. Hrabowski III, J. Kathleen Tracy, and Peter H. Henderson proteins in vertebrate tissue coloration. See the article by Taboada et al. on pages 18574–18581. Image credit: INNER WORKINGS—An over-the-shoulder look at scientists at work Santiago R. Ron. 18142 A pulse of hope in the fight against Alzheimer’s Lynne Peeples

QNAS 18146 QnAs with Hashim Al-Hashimi Brian Doctrow

COMMENTARIES 18148 Honey bee colony aggression and indirect genetic effects Marla B. Sokolowski See companion article on page 17135 in issue 29 of volume 117 + 18151 Maladaptive response of arterial myocytes to chronic exposure to Ca2 channel blockers Samantha C. O’Dwyer, Manuel F. Navedo, and L. F. Santana See companion article on page 17369 in issue 29 of volume 117 18154 Cats as predators and early domesticates in ancient human landscapes Fiona Marshall See companion article on page 17710 in issue 30 of volume 117

LETTERS 18157 Complications and challenges for securing Mediterranean timelines Sturt W. Manning

Free online through the PNAS open access option. PNAS u August 4, 2020 u vol. 117 u no. 31 u iii–viii Downloaded by guest on September 29, 2021 18159 Reply to Manning: Dating of Gordion tree- 18470 Calcium-triggered fusion of lipid membranes is ring sequence still stands within a year enabled by amphiphilic nanoparticles of 745 BC Mukarram A. Tahir, Zekiye P. Guven, Laura R. Arriaga, Berta Charlotte Pearson, Matthew Salzer, Lukas Wacker, Peter Tinao, Yu-Sang Sabrina Yang, Ahmet Bekdemir, Jacob T. Brewer, Adam Sookdeo, and Peter Kuniholm Martin, Alisha N. Bhanji, Darrell Irvine, Francesco Stellacci, and Alfredo Alexander-Katz 18477 Machine learning classification can reduce false INAUGURAL ARTICLE positives in structure-based virtual screening 18161 Multidecadal records of intrinsic water-use efficiency Yusuf O. Adeshina, Eric J. Deeds, and John Karanicolas in the desert shrub Encelia farinosa reveal strong 18869 A mechanism-aware and multiomic machine-learning responses to climate change pipeline characterizes yeast cell growth Avery W. Driscoll, Nicholas Q. Bitter, Darren R. Sandquist, Christopher Culley, Supreeta Vijayakumar, Guido Zampieri, and James R. Ehleringer and Claudio Angione

BRIEF REPORTS CHEMISTRY 18169 Discovery of the world’s highest-dwelling mammal 18206 Lipid sponge droplets as programmable Jay F. Storz, Marcial Quiroga-Carmona, Juan C. Opazo, synthetic organelles Thomas Bowen, Matthew Farson, Scott J. Steppan, Ahanjit Bhattacharya, Henrike Niederholtmeyer, Kira A. and Guillermo D’Elı´a Podolsky, Rupak Bhattacharya, Jing-Jin Song, Roberto J. Brea, 18172 Inefficient V(D)J recombination underlies monogenic Chu-Hsien Tsai, Sunil K. Sinha, and Neal K. Devaraj T cell receptor β expression 18216 Two-step reaction mechanism reveals new Glendon S. Wu and Craig H. Bassing antioxidant capability of cysteine disulfides 18175 Identification of GLUT12/SLC2A12 as a urate against hydroxyl radical attack transporter that regulates the blood urate Sarju Adhikari, Ramon Crehuet, Josep M. Anglada, Joseph S. Francisco, and Yu Xia level in hyperuricemia model mice Yu Toyoda, Tappei Takada, Hiroshi Miyata, Hirotaka 18224 Crystallographic evidence of Watson–Crick Matsuo, Hidetoshi Kassai, Kazuki Nakao, Masahiro connectivity in the base pair of anionic Nakatochi, Yusuke Kawamura, Seiko Shimizu, Nariyoshi adenine with thymine Shinomiya, Kimiyoshi Ichida, Makoto Hosoyamada, Atsu Aiba, Manish Kumar Mishra, Steven P. Kelley, Volodymyr Smetana, and Hiroshi Suzuki David A. Dixon, Ashley S. McNeill, Anja-Verena Mudring, and Robin D. Rogers PHYSICAL SCIENCES 18231 Experimental and theoretical evidence for hydrogen doping in polymer solution-processed indium APPLIED MATHEMATICS gallium oxide 18355 Relating size and functionality in human social Wei Huang, Po-Hsiu Chien, Kyle McMillen, Sawankumar networks through complexity Patel, Joshua Tedesco, Li Zeng, Subhrangsu Mukherjee, Binghao Wang, Yao Chen, Gang Wang, Yang Wang, B. J. West, G. F. Massari, G. Culbreth, R. Failla, M. Bologna, Yanshan Gao, Michael J. Bedzyk, Dean M. DeLongchamp, R. I. M. Dunbar, and P. Grigolini Yan-Yan Hu, Julia E. Medvedeva, Tobin J. Marks, and Antonio Facchetti APPLIED PHYSICAL SCIENCES 18880 Thermodynamic energetics underlying genomic 18178 Plato’s cube and the natural geometry instability and whole-genome doubling in cancer of fragmentation Francoise Remacle, Thomas G. Graeber, and R. D. Levine Ga´bor Domokos, Douglas J. Jerolmack, Ferenc Kun, and Ja´nos To¨ro¨k EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 18186 Reconfigurable microbots folded from simple colloidal chains 18240 Automated detection of archaeological mounds Tao Yang, Brennan Sprinkle, Yang Guo, Jun Qian, using machine-learning classification of multisensor Daoben Hua, Aleksandar Donev, David W. M. Marr, and multitemporal satellite data and Ning Wu Hector A. Orengo, Francesc C. Conesa, Arnau Garcia-Molsosa, Agustı´n Lobo, Adam S. Green, Marco Madella, and Cameron A. Petrie ASTRONOMY 18194 Predicting the long-term stability of compact 18251 Recent anthropogenic curtailing of Yellow River multiplanet systems runoff and sediment load is unprecedented Daniel Tamayo, Miles Cranmer, Samuel Hadden, Hanno over the past 500 y Rein, Peter Battaglia, Alysa Obertas, Philip J. Armitage, Yu Liu, Huiming Song, Zhisheng An, Changfeng Sun, Valerie Shirley Ho, David N. Spergel, Christian Gilbertson, Trouet, Qiufang Cai, Ruoshi Liu, Steven W. Leavitt, Yi Naireen Hussain, Ari Silburt, Daniel Jontof-Hutter, Song, Qiang Li, Congxi Fang, Weijian Zhou, Yinke Yang, and Kristen Menou Zhao Jin, Yunqiang Wang, Junyan Sun, Xingmin Mu, Ying Lei, Lu Wang, Xuxiang Li, Meng Ren, Linlin Cui, and Xueli Zeng BIOPHYSICS AND COMPUTATIONAL BIOLOGY 18258 Elevated paleomagnetic dispersion at Saint Helena 18431 An influenza A hemagglutinin small-molecule fusion suggests long-lived anomalous behavior in the inhibitor identified by a new high-throughput South Atlantic fluorescence polarization screen Yael A. Engbers, Andrew J. Biggin, and Richard K. Bono Yao Yao, Rameshwar U. Kadam, Chang-Chun David Lee, Jordan L. Woehl, Nicholas C. Wu, Xueyong Zhu, Seiya 18264 Exoplanet secondary atmosphere loss and revival Kitamura, Ian A. Wilson, and Dennis W. Wolan Edwin S. Kite and Megan N. Barnett

iv u www.pnas.org Contents Downloaded by guest on September 29, 2021 18272 Elevated dust depositions in West Asia linked to 18355 Relating size and functionality in human social ocean–atmosphere shifts during North Atlantic networks through complexity cold events B. J. West, G. F. Massari, G. Culbreth, R. Failla, M. Bologna, Reza Safaierad, Mahyar Mohtadi, Bernd Zolitschka, Yusuke R. I. M. Dunbar, and P. Grigolini Yokoyama, Christoph Vogt, and Enno Schefuß 18359 Integration of ancient DNA with transdisciplinary 18278 Soft transition between subcritical and supercritical dataset finds strong support for Inca resettlement currents through intermittent cascading in the south Peruvian coast interfacial instabilities Jacob L. Bongers, Nathan Nakatsuka, Colleen O’Shea, Jorge Salinas, S. Balachandar, Mrugesh Shringarpure, Juan Thomas K. Harper, Henry Tantalea´n, Charles Stanish, Fedele, David Hoyal, and Mariano Cantero and Lars Fehren-Schmitz 18285 High-pressure elastic properties of dolomite melt supporting carbonate-induced melting in deep PSYCHOLOGICAL AND COGNITIVE SCIENCES upper mantle 18369 Robust evidence for bisexual orientation among men Man Xu, Zhicheng Jing, Suraj K. Bajgain, Mainak Mookherjee, Jeremy Jabbour, Luke Holmes, David Sylva, Kevin J. James A. Van Orman, Yu, and Yanbin Wang Hsu, Theodore L. Semon, A. M. Rosenthal, Adam Safron, Erlend Slettevold, Tuesday M. Watts-Overall, ENGINEERING Ritch C. Savin-Williams, John Sylla, Gerulf Rieger, and J. Michael Bailey 18292 Pencil–paper on-skin electronics Yadong Xu, Ganggang Zhao, Liang Zhu, Qihui Fei, Zhe Zhang, Zanyu Chen, Fufei An, Yangyang Chen, Yun Ling, Peijun Guo, SOCIAL SCIENCES Shinghua Ding, Guoliang Huang, Pai-Yen Chen, Qing Cao, 18378 Lay theories of peace and their influence on policy and Zheng Yan preference during violent conflict 18302 Reproductive outcomes predicted by phase imaging Oded Adomi Leshem and Eran Halperin with computational specificity of spermatozoon ultrastructure BIOLOGICAL SCIENCES Mikhail E. Kandel, Marcello Rubessa, Yuchen R. He, Sierra Schreiber, Sasha Meyers, Luciana Matter Naves, Molly K. AGRICULTURAL SCIENCES Sermersheim, G. Scott Sell, Michael J. Szewczyk, Nahil Sobh, Matthew B. Wheeler, and Gabriel Popescu 18317 Qualitative crop condition survey reveals spatiotemporal production patterns and 18310 Bioinspired conductive cellulose liquid-crystal allows early yield prediction hydrogels as multifunctional electrical Santiago Beguerı´a and Marco P. Maneta Zhuohao Zhang, Zhuoyue Chen, Yu Wang, and Yuanjin Zhao 18385 Crop rotation mitigates impacts of corn rootworm ENVIRONMENTAL SCIENCES resistance to transgenic Bt corn 18317 Qualitative crop condition survey reveals Yves Carrie`re, Zachary Brown, Serkan Aglasan, Pierre Dutilleul, Matthew Carroll, Graham Head, Bruce E. Tabashnik, Peter spatiotemporal production patterns and Søgaard Jørgensen, and Scott P. Carroll allows early yield prediction Santiago Beguerı´a and Marco P. Maneta ANTHROPOLOGY PHYSICS 18393 A 1.4-million-year-old bone handaxe from Konso, 18324 Cavity molecular dynamics simulations of liquid water Ethiopia, shows advanced tool technology in under vibrational ultrastrong coupling the early Acheulean Tao E. Li, Joseph E. Subotnik, and Abraham Nitzan Katsuhiro Sano, Yonas Beyene, Shigehiro Katoh, Daisuke Koyabu, Hideki Endo, Tomohiko Sasaki, Berhane Asfaw, 18332 Link-usage asymmetry and collective patterns emerging and Gen Suwa from -club organization of complex networks Paolo Moretti and Marc-Thorsten Hu¨tt APPLIED BIOLOGICAL SCIENCES 18341 Linear resistivity and Sachdev-Ye-Kitaev (SYK) spin 18401 Phosphoprotein-based biomarkers as predictors for liquid behavior in a quantum critical metal with cancer therapy spin-1=2 fermions Angela M. Carter, Chunfeng Tan, Karine Pozo, Rahul Telange, Peter Cha, Nils Wentzell, Olivier Parcollet, Antoine Georges, Roberto Molinaro, Ailan Guo, Enrica De Rosa, Jonathan O. and Eun-Ah Kim Martinez, Shanrong Zhang, Nilesh Kumar, Masaya Takahashi, Thorsten Wiederhold, Hans K. Ghayee, Sarah C. Oltmann, SUSTAINABILITY SCIENCE Karel Pacak, Eugene A. Woltering, Kimmo J. Hatanpaa, 18347 Biocement stabilization of an experimental-scale Fiemu E. Nwariaku, Elizabeth G. Grubbs, Anthony J. Gill, artificial slope and the reformation of iron-rich crusts Bruce Robinson, Frank Gillardon, Sushanth Reddy, Renata Alan Levett, Emma J. Gagen, Yitian Zhao, Paulo M. Jaskula-Sztul, James A. Mobley, M. Shahid Mukhtar, Ennio Vasconcelos, and Gordon Southam Tasciotti, Herbert Chen, and James A. Bibb 18412 A single-cell Raman-based platform to identify SOCIAL SCIENCES developmental stages of human pluripotent stem cell-derived neurons ANTHROPOLOGY Chia-Chen Hsu, Jiabao Xu, Bas Brinkhof, Hui Wang, Zhanfeng 18240 Automated detection of archaeological mounds Cui, Wei E. Huang, and Hua Ye using machine-learning classification of multisensor 18424 Bidirectional titration of yeast gene expression using and multitemporal satellite data a pooled CRISPR guide RNA approach Hector A. Orengo, Francesc C. Conesa, Arnau Garcia-Molsosa, K. Bowman, Matthew Deaner, Jan-Fang Cheng, Agustı´n Lobo, Adam S. Green, Marco Madella, Robert Evans, Ernst Oberortner, Yasuo Yoshikuni, and Cameron A. Petrie and Hal S. Alper

Contents PNAS u August 4, 2020 u vol. 117 u no. 31 u v Downloaded by guest on September 29, 2021 BIOCHEMISTRY 18530 Vps13 is required for the packaging of the ER into 18206 Lipid sponge droplets as programmable autophagosomes during ER-phagy synthetic organelles Shuliang Chen, Muriel Mari, Smriti Parashar, Dongmei Liu, Yixian Ahanjit Bhattacharya, Henrike Niederholtmeyer, Kira A. Cui, Fulvio Reggiori, Peter J. Novick, and Susan Ferro-Novick Podolsky, Rupak Bhattacharya, Jing-Jin Song, Roberto J. Brea, 18540 Clusters of bacterial RNA polymerase are Chu-Hsien Tsai, Sunil K. Sinha, and Neal K. Devaraj biomolecular condensates that assemble through 18431 An influenza A hemagglutinin small-molecule fusion liquid–liquid phase separation inhibitor identified by a new high-throughput Anne-Marie Ladouceur, Baljyot Singh Parmar, Stefan fluorescence polarization screen Biedzinski, James Wall, S. Graydon Tope, David Cohn, Yao Yao, Rameshwar U. Kadam, Chang-Chun David Lee, Albright Kim, Nicolas Soubry, Rodrigo Reyes-Lamothe, Jordan L. Woehl, Nicholas C. Wu, Xueyong Zhu, Seiya and Stephanie C. Weber Kitamura, Ian A. Wilson, and Dennis W. Wolan ECOLOGY 18439 Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance 18161 Multidecadal records of intrinsic water-use efficiency Encelia farinosa DNA methylation in the desert shrub reveal strong Wendan Ren, Huitao Fan, Sara A. Grimm, Yiran Guo, Jae Jin responses to climate change Kim, Jiekai Yin, Linhui Li, Christopher J. Petell, Xiao-Feng Tan, Avery W. Driscoll, Nicholas Q. Bitter, Darren R. Sandquist, Zhi-Min Zhang, John P. Coan, Linfeng Gao, Ling Cai, Brittany and James R. Ehleringer Detrick, Burak C¸etin, Qiang Cui, Brian D. Strahl, Or Gozani, 18550 High plant diversity and slow assembly of old- Yinsheng Wang, Kyle M. Miller, Sea´n E. O’Leary, Paul A. growth grasslands Wade, Dinshaw J. Patel, Gang Greg Wang, and Jikui Song Ashish N. Nerlekar and Joseph W. Veldman 2+ 18448 What ATP binding does to the Ca pump and how 18557 Shifts in timing and duration of breeding for 73 nonproductive phosphoryl transfer is prevented in + boreal bird species over four decades the absence of Ca2 Maria H. Ha¨llfors, Laura H. Anta˜o, Malcolm Itter, Aleksi 椛島佳樹 小川治夫 Yoshiki Kabashima ( ), Haruo Ogawa ( ), Rie Lehikoinen, Tanja Lindholm, Tomas Roslin, 中島理恵 豊島近 Nakajima ( ), and Chikashi Toyoshima ( ) and Marjo Saastamoinen 18459 Long-range intramolecular allostery and regulation in 18566 Behavioral traits that define social dominance are the the dynein-like AAA protein Mdn1 same that reduce social influence in a consensus task Keith J. Mickolajczyk, Paul Dominic B. Olinares, Yiming Niu, Mariana Rodriguez-Santiago, Paul Nu¨hrenberg, James Derry, Nan Chen, Sara E. Warrington, Yusuke Sasaki, Thomas Walz, Oliver Deussen, Fritz A. Francisco, Linda K. Garrison, Sylvia F. Brian T. Chait, and Tarun M. Kapoor Garza, Hans A. Hofmann, and Alex Jordan

BIOPHYSICS AND COMPUTATIONAL BIOLOGY ENVIRONMENTAL SCIENCES 18470 Calcium-triggered fusion of lipid membranes is 18347 Biocement stabilization of an experimental-scale enabled by amphiphilic nanoparticles artificial slope and the reformation of iron-rich crusts Mukarram A. Tahir, Zekiye P. Guven, Laura R. Arriaga, Berta Alan Levett, Emma J. Gagen, Yitian Zhao, Paulo M. Tinao, Yu-Sang Sabrina Yang, Ahmet Bekdemir, Jacob T. Vasconcelos, and Gordon Southam Martin, Alisha N. Bhanji, Darrell Irvine, Francesco Stellacci, and Alfredo Alexander-Katz EVOLUTION 18477 Machine learning classification can reduce false 18574 Multiple origins of green coloration in frogs mediated positives in structure-based virtual screening by a novel biliverdin-binding serpin Yusuf O. Adeshina, Eric J. Deeds, and John Karanicolas Carlos Taboada, Andre´s E. Brunetti, Mariana L. Lyra, Robert R. 18489 HEDGES error-correcting code for DNA storage Fitak, Ana Faigo´n Soverna, Santiago R. Ron, Marı´a G. Lagorio, corrects indels and allows sequence constraints Ce´lio F. B. Haddad, Norberto P. Lopes, Sonkë Johnsen, Julia´n William H. Press, John A. Hawkins, Stephen K. Jones Jr, Faivovich, Lucı´a B. Chemes, and Sara E. Bari Jeffrey M. Schaub, and Ilya J. Finkelstein 18582 Evolutionary stalling and a limit on the power of 18497 Cryo-EM analysis of a membrane protein embedded natural selection to improve a cellular module in the liposome Sandeep Venkataram, Ross Monasky, Shohreh H. Sikaroodi, Xia Yao, Xiao Fan, and Nieng Yan Sergey Kryazhimskiy, and Betul Kacar 18504 Calcium and hydroxyapatite binding site of human vitronectin provides insights to abnormal GENETICS deposit formation 18591 Metformin inhibits RAN translation through PKR Kyungsoo Shin, James E. Kent, Chandan Singh, Lynn M. pathway and mitigates disease in C9orf72 Fujimoto, Jinghua Yu, Ye Tian, Wonpil Im, ALS/FTD mice and Francesca M. Marassi Tao Zu, Shu Guo, Olgert Bardhi, Daniel A. Ryskamp, Jian Li, Solaleh Khoramian Tusi, Avery Engelbrecht, Kelena Klippel, CELL BIOLOGY Paramita Chakrabarty, Lien Nguyen, Todd E. Golde, Nahum 18511 Cleavage-furrow formation without F-actin Sonenberg, and Laura P. W. Ranum in Chlamydomonas 18600 Molecular characterization of a fungal gasdermin- Masayuki Onishi, James G. Umen, Frederick R. Cross, like protein and John R. Pringle Asen Daskalov, Patrick S. Mitchell, Andrew Sandstrom, 18521 Last step in the path of LDL cholesterol from Russell E. Vance, and N. Louise Glass lysosome to plasma membrane to ER is 18608 Genome-wide role of Rad26 in promoting governed by phosphatidylserine transcription-coupled nucleotide excision Michael N. Trinh, Michael S. Brown, Joseph L. Goldstein, Jaeil repair in yeast chromatin Han, Gonc¸ Vale, Jeffrey G. McDonald, Joachim Seemann, Mingrui Duan, Kathiresan Selvam, John J. Wyrick, Joshua T. Mendell, and Feiran Lu and Peng Mao

vi u www.pnas.org Contents Downloaded by guest on September 29, 2021 18617 T-box transcription factor 3 governs a transcriptional 18719 Nanoparticles presenting clusters of CD4 expose program for the function of the mouse a universal vulnerability of HIV-1 by mimicking atrioventricular conduction system target cells Rajiv A. Mohan, Fernanda M. Bosada, Jan H. van Weerd, Magnus A. G. Hoffmann, Yotam Bar-On, Zhi Yang, Karel van Duijvenboden, Jianan Wang, Mathilda T. M. Harry B. Gristick, Priyanthi N. P. Gnanapragasam, Mommersteeg, Ingeborg B. Hooijkaas, Vincent Wakker, Jost Vielmetter, Michel C. Nussenzweig, Corrie de Gier-de Vries, Ruben Coronel, Gerard J. J. and Pamela J. Bjorkman Boink, Jeroen Bakkers, Phil Barnett, Bas J. Boukens, 18729 Wide lag time distributions break a trade- and Vincent M. Christoffels off between reproduction and survival in bacteria IMMUNOLOGY AND INFLAMMATION Stefany Moreno-Ga´mez, Daniel J. Kiviet, Cle´ment Vulin, 18627 Bacterial immunotherapy for cancer induces Susan Schlegel, Kim Schlegel, G. Sander van Doorn, CD4-dependent tumor-specific immunity through and Martin Ackermann γ tumor-intrinsic interferon- signaling 18737 The gain-of-function allele bamAE470K bypasses the Anthony C. Antonelli, Anna Binyamin, Tobias M. Hohl, essential requirement for BamD in β-barrel outer Michael S. Glickman, and Gil Redelman-Sidi membrane protein assembly 18638 Fetal public Vγ9Vδ2 T cells expand and gain potent Elizabeth M. Hart, Meera Gupta, Martin Wu¨hr, cytotoxic functions early after birth and Thomas J. Silhavy Maria Papadopoulou, Tanya Dimova, Muki Shey, Libby Briel, 18744 Morphological profiling of tubercle bacilli identifies Helen Veldtsman, Nondumiso Khomba, Hadn Africa, Marcia drug pathways of action Steyn, Willem A. Hanekom, Thomas J. Scriba, Elisa Nemes, Trever C. Smith II, Krista M. Pullen, Michaela C. Olson, and David Vermijlen Morgan E. McNellis, Ian Richardson, Sophia Hu, Jonah 18649 Microbial exposure drives polyclonal expansion of Larkins-Ford, Xin Wang, Joel S. Freundlich, D. Michael innate γδ T cells immediately after birth Ando, and Bree B. Aldridge Sarina Ravens, Alina S. Fichtner, Maike Willers, Dennis 18754 Fc-mediated effector function contributes to Torkornoo, Sabine Pirr, Jennifer Scho¨ning, Malte Deseke, Inga the in vivo antiviral effect of an HIV Sandrock, Anja Bubke, Anneke Wilharm, Daniel Dodoo, neutralizing antibody Beverly Egyir, Katie L. Flanagan, Lars Steinbru¨ck, Paul Dickinson, Peter Ghazal, Bright Adu, Dorothee Viemann, Mangaiarkarasi Asokan, Joana Dias, Cuiping Liu, Anna and Immo Prinz Maximova, Keenan Ernste, Amarendra Pegu, Krisha McKee, Wei Shi, Xuejun Chen, Cassandra Almasri, Wanwisa Promsote, David R. Ambrozak, Lucio Gama, Jianfei Hu, MEDICAL SCIENCES Daniel C. Douek, John-Paul Todd, Jeffrey D. Lifson, Slim 18661 Site-specific ubiquitination of pathogenic huntingtin Fourati, Rafick P. Sekaly, Andrew R. Crowley, Margaret E. attenuates its deleterious effects Ackerman, Sung Hee Ko, Divya Kilam, Eli A. Boritz, Laura E. Liao, Katharine Best, Alan S. Perelson, John R. Mascola, Vicky Hakim-Eshed, Ayub Boulos, Chen Cohen-Rosenzweig, and Richard A. Koup Libo Yu-Taeger, Tamar Ziv, Yong Tae Kwon, Olaf Riess, Hoa Huu Phuc Nguyen, Noam E. Ziv, and Aaron Ciechanover 18764 FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation MICROBIOLOGY Andrew E. Hale, Donna Collins-McMillen, Erik M. Lenarcic, 18670 High-throughput discovery of phage receptors Suzu Igarashi, Jeremy P. Kamil, Felicia Goodrum, using transposon insertion sequencing and Nathaniel J. Moorman of bacteria 18771 Human cytomegalovirus protein pUL36: A dual cell Kaitlyn E. Kortright, Benjamin K. Chan, and Paul E. Turner death pathway inhibitor 18680 Subdomain cryo-EM structure of nodaviral replication Alice Fletcher-Etherington, Luis Nobre, Katie Nightingale, protein A crown complex provides mechanistic Robin Antrobus, Jenna Nichols, Andrew J. Davison, Richard J. insights into RNA genome replication Stanton, and Michael P. Weekes Nuruddin Unchwaniwala, Hong Zhan, Janice Pennington, Mark Horswill, Johan A. den Boon, and Paul Ahlquist NEUROSCIENCE 18692 Intact proviral DNA assay analysis of large cohorts of 18780 A connectomics approach to understanding people with HIV provides a benchmark for the a retinal disease frequency and composition of persistent Charles L. Zucker, Paul S. Bernstein, Richard L. Schalek, Jeff W. Lichtman, and John E. Dowling proviral DNA Francesco R. Simonetti, Jennifer A. White, Camille Tumiotto, 18788 Integrative structural, functional, and Kristen D. Ritter, Mian Cai, Rajesh T. Gandhi, Steven G. transcriptomic analyses of sex-biased brain Deeks, Bonnie J. Howell, Luis J. Montaner, Joel N. organization in humans Blankson, Albine Martin, Gregory M. Laird, Robert F. Siliciano, Siyuan Liu, Jakob Seidlitz, Jonathan D. Blumenthal, S. John W. Mellors, and Janet D. Siliciano Clasen, and Armin Raznahan 18701 Yin Yang 1 is a potent activator of human T 18799 V1 neurons encode the perceptual compensation of lymphotropic virus type 1 LTR-driven gene false torsion arising from Listing’s law expression via RNA binding Mohammad Farhan Khazali, Hamidreza Ramezanpour, Gary Z. Wang and Stephen P. Goff and Peter Thier 18711 Molecular basis of Coxsackievirus A10 entry using 18810 Redistribution of metabolic resources the two-in-one attachment and uncoating through astrocyte networks mitigates receptor KRM1 neurodegenerative stress Yingzi Cui, Ruchao Peng, Hao Song, Zhou Tong, Xiao Qu, Melissa L. Cooper, Silvia Pasini, Wendi S. Lambert, Sheng Liu, Xin Zhao, Yan Chai, Peiyi Wang, George F. Gao, Karis B. D’Alessandro, Vincent Yao, Michael L. Risner, and Jianxun Qi and David J. Calkins

Contents PNAS u August 4, 2020 u vol. 117 u no. 31 u vii Downloaded by guest on September 29, 2021 PHYSIOLOGY 18880 Thermodynamic energetics underlying genomic 18822 TNNT2 mutations in the tropomyosin binding region instability and whole-genome doubling in cancer of TNT1 disrupt its role in contractile inhibition Francoise Remacle, Thomas G. Graeber, and R. D. Levine and stimulate cardiac dysfunction Aditi Madan, Meera C. Viswanathan, Kathleen C. Woulfe, William Schmidt, Agnes Sidor, Ting Liu, Tran H. Nguyen, Bosco CORRECTIONS Trinh, Cortney Wilson, Sineej Madathil, Georg Vogler, Brian O’Rourke, Brandon J. Biesiadecki, Larry S. Tobacman, ANTHROPOLOGY, CHEMISTRY and Anthony Cammarato 18891 Securing timelines in the ancient Mediterranean using multiproxy annual tree-ring data PLANT BIOLOGY Charlotte Pearson, Matthew Salzer, Lukas Wacker, Peter 18832 Induced proximity of a TIR signaling domain on Brewer, Adam Sookdeo, and Peter Kuniholm a plant-mammalian NLR chimera activates defense in plants MEDICAL SCIENCES, CHEMISTRY Zane Duxbury, Shanshan Wang, Craig I. MacKenzie, 18892 The intelligent knife (iKnife) and its intraoperative Jeannette L. Tenthorey, Xiaoxiao Zhang, Sung Un Huh, Lanxi diagnostic advantage for the treatment of Hu, Lionel Hill, Pok Man Ngou, Pingtao Ding, Jian Chen, Yan Ma, Hailong Guo, Baptiste Castel, Panagiotis N. Moschou, cervical disease Maud Bernoux, Peter N. Dodds, Russell E. Vance, Menelaos Tzafetas, Anita Mitra, Maria Paraskevaidi, Zsolt and Jonathan D. G. Jones Bodai, Ilkka Kalliala, Sarah Bowden, Konstantinos Lathouras, Francesca Rosini, Marcell Szasz, Adele Savage, Julia Balog, 18840 Light modulates the gravitropic responses through James McKenzie, Deirdre Lyons, Phillip Bennett, David organ-specific PIFs and HY5 regulation of LAZY4 MacIntyre, Sadaf Ghaem-Maghami, Zoltan Takats, expression in Arabidopsis and Maria Kyrgiou Panyu Yang, Qiming Wen, Renbo Yu, Xue Han, Xing Wang Deng, and Haodong Chen + + 18849 Tonoplast-localized Ca2 pumps regulate Ca2 SI CORRECTION signals during pattern-triggered immunity in Arabidopsis thaliana MEDICAL SCIENCES Richard Hilleary, Julio Paez-Valencia, Cullen Vens, Masatsugu 18893 Inhibition of de novo lipogenesis targets androgen Toyota, Michael Palmgren, and Simon Gilroy receptor signaling in castration-resistant 18858 Allosteric deactivation of PIFs and EIN3 by prostate cancer microproteins in light control of plant development Giorgia Zadra, Caroline F. Ribeiro, Paolo Chetta, Yeung Ho, Stefano Cacciatore, Xueliang Gao, Sudeepa Syamala, Clyde Qingqing Wu, Kunyan Kuang, Mohan Lyu, Yan Zhao, Yue Li, Bango, Cornelia Photopoulos, Ying Huang, Svitlana Jing Li, Ying Pan, Hui Shi, and Shangwei Zhong Tyekucheva, Debora C. Bastos, Jeremy Tchaicha, Brian Lawney, Takuma Uo, Laura D’Anello, Alfredo Csibi, Radha SYSTEMS BIOLOGY Kalekar, Benjamin Larimer, Leigh Ellis, Lisa M. Butler, Colm 18869 A mechanism-aware and multiomic machine-learning Morrissey, Karen McGovern, Vito J. Palombella, Jeffery L. pipeline characterizes yeast cell growth Kutok, Umar Mahmood, Silvano Bosari, Julian Adams, Christopher Culley, Supreeta Vijayakumar, Guido Zampieri, Stephane Peluso, Scott M. Dehm, Stephen R. Plymate, and Claudio Angione and Massimo Loda

viii u www.pnas.org Contents Downloaded by guest on September 29, 2021