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Kenneth Martin Rosenberg Email: [email protected], [email protected] 660 West Redwood Street, Howard Hall Room 332D, Baltimore, MD, 21201

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Kenneth Martin Rosenberg Email: Kenneth.Rosenberg@Som.Umaryland.Edu, Kenny.M.Rosenberg@Gmail.Com 660 West Redwood Street, Howard Hall Room 332D, Baltimore, MD, 21201 The impact of the non-immune chemiome on T cell activation Item Type dissertation Authors Rosenberg, Kenneth Publication Date 2020 Abstract T cells are critical organizers of the immune response and rigid control over their activation is necessary for balancing host defense and immunopathology. It takes 3 signals provided by dendritic cells (DC) to fully activate a T cell response – T ce... Keywords signaling; T cell; T-Lymphocytes--immunology Download date 02/10/2021 13:41:58 Link to Item http://hdl.handle.net/10713/14477 Kenneth Martin Rosenberg Email: [email protected], [email protected] 660 West Redwood Street, Howard Hall Room 332D, Baltimore, MD, 21201 EDUCATION MD, University of Maryland, Baltimore, MD Expected May 2022 PhD, University of Maryland, Baltimore, MD December 2020 Graduate Program: Molecular Microbiology and Immunology (MMI) BS, University of Maryland, College Park, MD May 2013 Major: Bioengineering, cum laude University Honors Citation, Gemstone Citation RESEARCH EXPERIENCE UMSOM Microbiology and Immunology Baltimore, MD July 2016-present PhD Candidate Principal Investigator: Dr. Nevil Singh Thesis: The impact of the non-immune chemiome on T cell activation Examined environmental stimuli from classically “non-immune” sources – growth factors, hormones, neurotransmitters, etc. – act to modulate T cell signaling pathways and the functional effects of activating encounters with dendritic cells. UMSOM Anatomy and Neurobiology Baltimore, MD May-August 2015 Rotating student Principal Investigator: Dr. Asaf Keller Studied the role of descending modulation pathways on affective pain transmission. Performed tract- tracing experiments using targeted injection of Cholera toxin subunit B into the lateral parabrachial nucleus and ventrolateral periaqueductal gray of anesthetized transgenic mice. FDA Center for Devices and Radiological Health Laurel, MD July 2013-June 2014 ORISE Research Fellow in the Laboratory of Cardiovascular and Interventional Therapeutics Principal Investigators: Dr. Bill Pritchard and Dr. John Karanian Studied the factors that contribute to endovascular implant failure. Analyzed CT angiograms using image-based geometric modeling techniques to characterize the in vivo loading environment in major blood vessels and cardiac structures. Assisting in imaging of animal subjects and other various surgical procedures. UMD Clark School of Engineering College Park, MD May 2012-May 2013 Orthopedic Mechanobiology Lab Faculty Mentor: Dr. Adam Hsieh, Department of Bioengineering Studied the role of the pericellular matrix in the mechanotransduction processes of human mesenchymal stem cells undergoing chondrogenesis. Analysis included real-time RT-PCR and immunofluorescence imaging techniques. Received an HHMI Undergraduate Fellowship to fund this research beginning spring 2013. Senior Capstone Project College Park, MD Fall 2012-Spring 2013 Physician Mentor: Dr. Ashutosh Sachdeva, University of Maryland Medical Center Faculty Mentor: Dr. Keith Herold, Department of Bioengineering Worked with four students to develop a sensor system to measure the reocclusion of silicone tracheal stents. The sensor was designed to detect the changing capacitance across the stent caused by the buildup of mucus or granulation tissue. It then wirelessly transmits a digital signal to an Android smart phone where the user could be alerted to the measurement results. Gemstone-Team RODENT College Park, MD Fall 2010-Spring 2013 Faculty Mentor: Dr. Brian Bequette, Department of Animal and Avian Sciences Collaborated with eleven students and a faculty mentor to perform research studying the underlying metabolic dysregulation associated with obesity using a mouse model. Was responsible for care of the mice as well as several lab procedures including dissections and sample processing. Received research grants from HHMI and ACCIAC. NIH National Institute on Aging Baltimore, MD Summer 2011 Summer Intern in the MRI and Spectroscopy Section of the Laboratory of Clinical Investigation Principal Investigator: Dr. Richard Spencer Studied the efficacy of diagnosing cartilage degradation using multiple MRI parameter analysis. TEACHING EXPERIENCE UMB, Dept. of Microbiology and Immunology Baltimore, MD Summer 2020 Lecturer – Overview of Immunology Summer Course Gave lectures regarding T cell antigen recognition and transplant immunology as part of a three- week virtual immunology course for summer internship students as well as incoming and current graduate students. University of Maryland SOM Baltimore, MD Fall 2018, Fall 2019 Small group leader – Host Defense and Infectious Diseases Led second year medical student discussion sections covering CAR-T cell therapy, virology basics, HPV vaccination, and Zika virus pathogenesis. Served as a leader for 4 sessions in 2018 and 3 in 2019. UMB Molecular Microbiology and Immunology Baltimore, MD Fall 2018, Fall 2019 Lecturer and discussion leader – Advances in Immunology Gave the Neuroimmunology overview lecture, including a history of the field and summary of recent literature highlighting the breadth of the field. Additionally, worked with a student in the course to select and present a paper discussion covering 2-3 recent journal articles. Was invited back to serve in the same role in fall of 2019. University of Maryland CMNS College Park, MD Fall 2011, Spring 2013 Undergraduate Teaching Assistant - Introduction to Genetics Fall 2011 - Led a class of 20 students in weekly discussion and held weekly office hours. Aided in the proctoring and grading of exams as well as graded other class assignments. Spring 2013 - Transitioned to a different role in which I managed the online resources available to the students and wrote weekly quizzes for students in all sections. Continued to maintain weekly office hours and aid in the proctoring and grading of exams. UNIVERSITY SERVICE UMB Molecular Microbiology and Immunology Admissions Committee Fall 2019-Spring 2020 Student representative and interviewer University of Maryland MSTP Admissions and Advisory Committee Fall 2016-Spring 2018 Student representative and interviewer University of Maryland School of Medicine Admissions Fall 2015-Spring 2016 Student interviewer University of Maryland School of Medicine Fall 2014-Spring 2016 Class of 2018 Class Council Treasurer PUBLICATIONS Rosenberg, KM, Singh, NJ. (2019) “Mouse T cells express a neurotransmitter-receptor signature that is quantitatively modulated in a subset- and activation-dependent manner.” Brain, Behavior, and Immunity. 80:275-285 Rosenberg, KM, Singh, NJ. VIP inhibits TCR-mediated ERK signaling to drive altered CD4 activation and differentiation. [Manuscript in prep] Fioretti S, Matson CA, Rosenberg KM, Singh NJ. Dynamic downregulation of CD19 by B cells underlies the escape phenotype after anti-CD19 directed immunotherapy. [Manuscript in prep] ABSTRACTS & PRESENTATIONS Oral Presentations Rosenberg, KM, Singh, NJ. “Neuronal regulation of immunity via T cell subset-specific neurotransmitter receptors.” Graduate Student Symposium, June 2019, UMB, Baltimore, MD. Rosenberg, KM, Singh, NJ. “Differential expression of neurotransmitter receptors by T cell subsets modifies their antigen-specific activation.” Graduate Student Symposium, June 2019, UMB, Baltimore, MD. Rosenberg, KM, Singh, NJ. “Subset-specific neurotransmitter receptor expression tunes T cell activation.” American Association of Immunologists: Immunology 2018. May 2018; Austin, TX. Rosenberg, KM, Singh, NJ. “A potential codex for neuronal regulation of peripheral T cells.” Graduate Student Symposium, June 2019, UMB, Baltimore, MD. Rosenberg, KM, Singh, NJ. “Neurotransmitters in the regulation of T cell function.” University of Maryland MSTP Summer Research Symposium. August 2016; Baltimore, MD. Rosenberg, KM, Keller, A. “Descending modulation of affective pain pathways.” University of Maryland MSTP Summer Research Symposium. August 2015; Baltimore, MD. Posters Rosenberg, KM, Singh, NJ. “Expression of T cell-subset-specific signatures of neurotransmitter receptors allows the nervous system to fine tune immune activation.” MD/PhD National Student Conference. July, 2019; Copper Mountain, CO. Rosenberg, KM, Singh, NJ. “Subset-specific neurotransmitter receptor expression tunes T cell activation.” American Association of Immunologists: Immunology 2018. May 2018; Austin, TX. Rosenberg, KM, Singh, NJ. “Families of neurotransmitter receptors are differentially regulated across T cell subsets.” American Association of Immunologists: Immunology 2017. May 2017; Washington, DC. Rosenberg, KM, Gregg, K, Leonard, S, Ries, S, Karanian, JW, Pritchard, WF. “Geometry and Motion of the Aortic Arch Across Species: Implications for Stent-Graft Device Evaluation and Development.” FDA CDRH Summer Student Poster Symposium. August 2013; White Oak, MD. Rosenberg, KM, Twomey, JD, Hsieh, AH. “Role of the pericellular matrix in the mechanotransduction pathways of hMSCs undergoing chondrogenesis.” HHMI Research Fellowship Program 14th Annual Research Symposium, University of Maryland. April 2013; College Park, MD. GRANTS University of Maryland MSTP T32 trainee Fall 2015-Spring 2016 Maryland-HHMI Undergraduate Research Fellowship Spring 2013 HONORS & AWARDS AAI Immunology 2018 – Trainee Abstract Award May 2018 University of Maryland Banneker/Key Scholar Fall 2009-Spring 2013 Abstract Title of Dissertation: The impact of the non-immune chemiome on T cell activation Kenneth M. Rosenberg, Doctor of Philosophy, 2020 Dissertation Directed by: Nevil
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