Energy and Epigenetics: Quantum Cell Theory, Life As a Collective Phenomena
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Quantum Biology: an Update and Perspective
quantum reports Review Quantum Biology: An Update and Perspective Youngchan Kim 1,2,3 , Federico Bertagna 1,4, Edeline M. D’Souza 1,2, Derren J. Heyes 5 , Linus O. Johannissen 5 , Eveliny T. Nery 1,2 , Antonio Pantelias 1,2 , Alejandro Sanchez-Pedreño Jimenez 1,2 , Louie Slocombe 1,6 , Michael G. Spencer 1,3 , Jim Al-Khalili 1,6 , Gregory S. Engel 7 , Sam Hay 5 , Suzanne M. Hingley-Wilson 2, Kamalan Jeevaratnam 4, Alex R. Jones 8 , Daniel R. Kattnig 9 , Rebecca Lewis 4 , Marco Sacchi 10 , Nigel S. Scrutton 5 , S. Ravi P. Silva 3 and Johnjoe McFadden 1,2,* 1 Leverhulme Quantum Biology Doctoral Training Centre, University of Surrey, Guildford GU2 7XH, UK; [email protected] (Y.K.); [email protected] (F.B.); e.d’[email protected] (E.M.D.); [email protected] (E.T.N.); [email protected] (A.P.); [email protected] (A.S.-P.J.); [email protected] (L.S.); [email protected] (M.G.S.); [email protected] (J.A.-K.) 2 Department of Microbial and Cellular Sciences, School of Bioscience and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK; [email protected] 3 Advanced Technology Institute, University of Surrey, Guildford GU2 7XH, UK; [email protected] 4 School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK; [email protected] (K.J.); [email protected] (R.L.) 5 Manchester Institute of Biotechnology, Department of Chemistry, The University of Manchester, -
Physics, Biology and the Origin of Life: the Physicians' View Geoffrey Goodman Phd1 and M
IMAJ • VOL 13 • DeceMber 2011 PERSPECTIVE Physics, Biology and the Origin of Life: The Physicians' View Geoffrey Goodman PhD1 and M. Eric Gershwin MD2 1Kfar Vradim, Israel 2Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA environment and were very much concerned with the insepa- ABSTRACT: Physicians have a great interest in discussions of life and its rable issue of 'what' is life and 'how' it relates to inanimate origin, including life's persistence through successive cycles matter. Physicians of those eras were more concerned about of self-replication under extreme climatic and man-made religion and the role of man and God than about physical sci- trials and tribulations. We review here the fundamental ence. One wonders what they would think today, with physical processes that, contrary to human intuition, life may be science dominated and puzzled by the apparent incompatibility seen heuristically as an ab initio, fundamental process between two fundamental concepts: general relativity (gravi- at the interface between the complementary forces of tational) theory that views matter-energy as an expression of gravitation and quantum mechanics. Analogies can predict a time-space continuum and quantum theory that considers applications of quantum mechanics to human physiology matter-energy in terms of discrete quantities (quanta) and in addition to that already being applied, in particular to waves and their counterintuitively weird behavior. The long- aspects of brain activity and pathology. This potential will also extend eventually to, for example, autoimmunity, held desire to unify these two fundamental laws of physics in genetic selection and aging. -
Neuroreceptor Activation by Vibration-Assisted Tunneling
OPEN Neuroreceptor Activation by SUBJECT AREAS: Vibration-Assisted Tunneling BIOPHYSICAL CHEMISTRY Ross D. Hoehn1, David Nichols2, Hartmut Neven3 & Sabre Kais4,5,6 MECHANISM OF ACTION 1Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA, 2Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA,3 Google, Venice, CA 90291, USA,4 Department of Received 5 20 October 2014 Chemistry, Purdue University, West Lafayette, IN 47907, USA, Departments of Physics, Purdue University, West Lafayette, IN 47907, USA,6 Qatar Environment and Energy Research Institute, Qatar Foundation, Doha, Qatar. Accepted 20 March 2015 G protein-coupled receptors (GPCRs) constitute a large family of receptor proteins that sense molecular Published signals on the exterior of a cell and activate signal transduction pathways within the cell. Modeling how an 24 April 2015 agonist activates such a receptor is fundamental for an understanding of a wide variety of physiological processes and it is of tremendous value for pharmacology and drug design. Inelastic electron tunneling spectroscopy (IETS) has been proposed as a model for the mechanism by which olfactory GPCRs are activated by a bound agonist. We apply this hyothesis to GPCRs within the mammalian nervous system Correspondence and using quantum chemical modeling. We found that non-endogenous agonists of the serotonin receptor share requests for materials a particular IET spectral aspect both amongst each other and with the serotonin molecule: a peak whose should be addressed to intensity scales with the known agonist potencies. We propose an experiential validation of this model by S.K. (kais@purdue. utilizing lysergic acid dimethylamide (DAM-57), an ergot derivative, and its deuterated isotopologues; we also provide theoretical predictions for comparison to experiment. -
Energy Medicine in Therapeutics and Human Performance / James L
B UTTERWORTH H EINEMANN An Imprint of Elsevier Science The Curtis Center Independence Square West Philadelphia, Pennsylvania 19106 ENERGY MEDICINE IN THERAPEUTICS AND ISBN 0-7506-5400-7 HUMAN PERFOMANCE Copyright © 2003, Elsevier Science (USA). All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier’s Health Sciences Rights Department in Philadelphia, PA, USA: phone: (+1) 215 238 7869, fax: (+1) 215 238 2239, e-mail: [email protected]. You may also complete your request on-line via the Elsevier Science homepage (http://www.elsevier.com), by selecting ‘Customer Support’ and then ‘Obtaining Permissions.’ NOTICE Complementary and alternative medicine is an ever-changing field. Standard safety precautions must be followed, but as new research and clinical experience broaden our knowledge, changes in treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current product information provided by the manufacturer of each drug to be administered to verify the rec- ommended dose, the method and duration of administration, and contraindications. It is the respon- sibility of the licensed prescriber, relying on experience and knowledge of the patient, to determine dosages and the best treatment for each individual patient. Neither the publisher nor the editors assume any liability for any injury and/or damage to persons or property arising from this publication. Library of Congress Cataloging-in-Publication Data Oschman, James L. -
Appendix Iii
APPENDIX III MY 1950-1972 LIFE IN PBio WAS EXHILARATING! by J. Walter Woodbury (1923 - ) PREFACE My memories are almost the sole source of the material in this document. Many experimental find- ings show that memories are notoriously malleable and often wrong. My intent is to provide personal glimpses of the early heady days of the buildup of the great Department of Physiology and Biophysics at the University of Washington, School of Medicine. I hope that these will convey something of the feel for what it was like to be there then. I checked most dates and quote a few paragraphs but it is difficult or impossible to document most of what I have written. I apologize for any factual errors and/or misattributions. _____________________________________________________________________________ PROLOG gree as fast as possible. I graduated with a BS in Academic family physics in August 1943, nine quarters later when I was barely 20. I had to take 20 credit hour the My grandfather John T. Woodbury, Sr. (1863- 1936) was a lifelong educator in St. George, UT last quarter and found out that the resulting con- in pioneer times, My father, Angus M. Wood- tinuous sensory overload temporarily greatly bury (1886-1964) obtained a PhD at 45 years of diminished my ability to learn. One of the pro- age and became a well-known biology/ecology fessors in the Physics department arranged for professor at the University of Utah. All four of me to join the Radiation Laboratory at MIT as a his sons completed PhDs, as did his two son-in- Staff Member on 1 October 1943. -
Membrane Potential Generation by the Ion Adsorption
membranes Article Ling’s Adsorption Theory as a Mechanism of Membrane Potential Generation Observed in Both Living and Nonliving Systems Hirohisa Tamagawa 1,*, Makoto Funatani 1 and Kota Ikeda 2 1 Department of Human and Information Systems, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan; [email protected] 2 Graduate School of Advanced Mathematical Sciences, Meiji University, 4-21-1, Nakano, Nakano-ku, Tokyo 165-8525, Japan; [email protected] * Correspondence: [email protected]; Tel.: +81-58-293-2529 Academic Editor: Spas Kolev Received: 28 September 2015; Accepted: 21 January 2016; Published: 26 January 2016 Abstract: The potential between two electrolytic solutions separated by a membrane impermeable to ions was measured and the generation mechanism of potential measured was investigated. From the physiological point of view, a nonzero membrane potential or action potential cannot be observed across the impermeable membrane. However, a nonzero membrane potential including action potential-like potential was clearly observed. Those observations gave rise to a doubt concerning the validity of currently accepted generation mechanism of membrane potential and action potential of cell. As an alternative theory, we found that the long-forgotten Ling’s adsorption theory was the most plausible theory. Ling’s adsorption theory suggests that the membrane potential and action potential of a living cell is due to the adsorption of mobile ions onto the adsorption site of cell, and this theory is applicable even to nonliving (or non-biological) system as well as living system. Through this paper, the authors emphasize that it is necessary to reconsider the validity of current membrane theory and also would like to urge the readers to pay keen attention to the Ling’s adsorption theory which has for long years been forgotten in the history of physiology. -
Quantum Microbiology
Curr. Issues Mol. Biol. 13: 43-50. OnlineQuantum journal at http://www.cimb.orgMicrobiology 43 Quantum Microbiology J. T. Trevors1* and L. Masson2* big bang. Currently, one of the signifcant unsolved problems in modern physics is how to merge the two into a unifying 1School of Environmental Sciences, University of Guelph, theory. Since quantum mechanics describes the physical 50 Stone Rd., East, Guelph, Ontario N1G 2W1, Canada world, and living organisms are physical entities, it is rational 2Biotechnology Research Institute, National Research and logical to examine the role of quantum mechanics in Council of Canada, 6100 Royalmount Ave., Montreal, the matter and energy of living microorganisms, especially Quebec H4P 2R2, Canada their origin about 4 billion years ago. To do so requires an understanding of quantum processes at the atomic scale and smaller where electrons, for example, do not collide Abstract with the atomic nucleus but defy electromagnetism and orbit During his famous 1943 lecture series at Trinity College at both an undefned speed and path around the nucleus. Dublin, the reknown physicist Erwin Schrödinger discussed One distinguishing characteristic of quantum mechanics the failure and challenges of interpreting life by classical is the Complementarity Principle (or wave-particle duality) physics alone and that a new approach, rooted in Quantum developed by Niels Bohr indicating that a particle can principles, must be involved. Quantum events are simply a possess multiple contradictory properties. level of organization below the molecular level. This includes A classic example of complementarity is Thomas the atomic and subatomic makeup of matter in microbial Young's famous light interference, and later on the double- metabolism and structures, as well as the organic, genetic slit, experiment showing that light or other quantum information codes of DNA and RNA. -
Plants Can Grow Quickly Or Ward Off Hungry Insects, but Not Both Plant's Ability to Identify, Block Invading Bacteria Examined
Plants Can Grow Quickly or Ward Off Hungry Insects, but Not Both Mar.29, 2010 in Botany, Nature, Science and Technology Leave a Comment Plant-eating insects such as this silhouetted caterpillar have played a pivotal role in the evolution of plants. (Credit: Photo by Ellen Woods, Cornell University) ScienceDaily (Mar. 27, 2010) — There's a war occurring each day in our backyards — plant versus plant-eating insect versus insect-eating insect. Research by UC Irvine's Kailen Mooney suggests the outcome [...] Plant’s Ability to Identify, Block Invading Bacteria Examined Mar.22, 2010 in Botany, Nature, Science and Technology Leave a Comment This is a flower of the Arabidopsis thaliana plant. (Credit: (USDA-Agriculture Research Service photo by Peggy Greb).) ScienceDaily (Mar. 21, 2010) — Understanding how plants defend themselves from bacterial infections may help researchers understand how people and other animals could be better protected from such pathogens. That's the idea behind a study to observe a [...] How Plants Put Down Roots: Geneticists Research Organ Development in the Plant Embryo Mar.17, 2010 in Botany, Science and Technology Leave a Comment One week old seed of the thale cress with embryo. (Credit: Martin Bayer / Max Planck Institute for Developmental Biology) ScienceDaily (Mar. 16, 2010) — In the beginning is the fertilized egg cell. Following numerous cell divisions, it then develops into a complex organism with different organs and tissues. The largely unexplained process whereby the [...] Can a Single Layer of Cells Control a Leaf’s Size? Mar.15, 2010 in Botany, Science and Technology Leave a Comment ScienceDaily (Mar. -
Gilbert Ling March 2020 NL EMD Published Version 2Nd Copy .Lwp
Ray Peat's Newsletter . .the invention of a useful product can only follow the understanding of the relevant underlying science. G. Ling Copyright 2020 Raymond Peat P.O. Box 5764 Eugene OR 97405 March 2020 Not for republication without written permission. These assumptions are built into the educa- Natural Order and tional system, and govern the way medicine is practiced, and the way research is done. Soon Gilbert Ling after beginning graduate study in the US, Ling developed a new electrode capable of making Two studies have estimated that the annual measurements inside a single cell (the Ling- number of deaths in the US caused by medical Gerard glass microelectrode), and his observa- errors ranks third, behind heart disease and cancer, tions using that instrument led him to question with estimates ranging from 250,000 to 440,000 the ruling doctrine that bioelectricity was deaths per year (Makary and Daniel, 2016; James, produced by an active membrane on the 2013, 2017). Many doctors acknowledge that a surface of cells. failure to report “adverse events” resulting in death is common. Behind these estimates is the fact that .… I have learnt from Professor those are errors recognized by doctors; their validity depends on the quality of medical education, and Gerard’s example the critical medical science. The presence of mistaken beliefs in importance to seek a broader the medical culture could mean that medicine’s real perspective than the experimental effect on life, health, and death is radically underes- subject being pursued at any one timated. This is something Gilbert Ling has often spoken about. -
Farqbio Forward Look 36P Dec2014.Indd
ESF Forward Look A Foresight Activity on Research in Quantum Biology (FarQBio) European Science Foundation (ESF) Forward Looks The European Science Foundation (ESF) was Forward Looks enable Europe’s scientific community, established in 1974 to provide a common platform in interaction with policy makers, to develop medium- for its Member Organisations – the main research to long-term views and analyses of future research funding and research performing organisations developments with the aim of defining research in Europe – to advance European research agendas at national and European level. Forward collaboration and explore new directions for Looks are driven by ESF’s Member Organisations research. ESF provides valuable services to the and, by extension, the European research scientific and academic communities – such as peer community. Quality assurance mechanisms, based review, evaluation, career tracking, conferences, on peer review where appropriate, are applied at implementation of new research support every stage of the development and delivery of a mechanisms and the hosting of high-level expert Forward Look to ensure its quality and impact. boards and committees – with the aim of supporting www.esf.org/flooks and driving the future of a globally competitive European Research Area. ESF currently has 66 member organisations in 29 countries. Authors www.esf.org Lead Authors: • Dr Luca Turin, Ulm University, Ulm, Germany • Professor Martin Plenio, Ulm University, Ulm, Germany Contributing Authors: • Dr Gerardo Adesso, University of Nottingham, Nottingham, United Kingdom • Professor Susana F. Huelga, Ulm University, Ulm, Germany • Professor Rienk van Grondelle, VU University Amsterdam, Amsterdam, Netherlands • Dr Fedor Jelezko, Ulm University, Ulm, Germany • Professor Yossi Paltiel, Hebrew University of Jerusalem, Jerusalem, Israel European Science Foundation • Dr Ana Helman, Science Officer • Dr Aigars Ekers, Science Officer (to March 2014) • Ms Chantal Durant, Administrative Coordinator ISBN: 978-2-36873-196-3 Contents Foreword 3 Executive Summary 5 1. -
Arxiv:0911.0155V1 [Quant-Ph] 1 Nov 2009 Oeotmsi Itr Htmyb Vrotmsi Nsm Aspects
Quantum physics meets biology Markus Arndt1, Thomas Juffmann1 and Vlatko Vedral2,3 1 Faculty of Physics, University of Vienna, Boltzmanngasse 5, 1090 Vienna, Austria 2 Atomic and Laser Physics, Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU, UK 3 Department of Physics + Centre for Quantum Technologies, National University of Singapore, 2 Science Drive 3, Singapore 117543 Abstract Quantum physics and biology have long been regarded as unrelated disciplines, describing nature at the inanimate microlevel on the one hand and living species on the other hand. Over the last decades the life sciences have succeeded in providing ever more and refined explanations of macroscopic phenomena that were based on an improved understanding of molecular structures and mechanisms. Simultaneously, quantum physics, originally rooted in a world view of quantum coherences, entanglement and other non- classical effects, has been heading towards systems of increasing complexity. The present perspective article shall serve as a pedestrian guide to the growing interconnections between the two fields. We recapitulate the generic and sometimes unintuitive characteristics of quantum physics and point to a number of applications in the life sciences. We discuss our criteria for a future quantum biology, its current status, recent experimental progress and also the restrictions that nature imposes on bold extrapolations of quantum theory to macroscopic phenomena. 1 Introduction While in the days of Darwin and Mendel the life sciences were mainly focusing on botany or zoology, modern biology, pharmacology and medicine are deeply rooted in a growing understanding of molecular interactions and organic information processing. Quantum physics, on the other hand, was initially centered on microscopic phenomena with photons, elec- trons and atoms. -
The Fourth Phase of Water Beyond Solid, Liquid, and Vapor
4 1 3 2 “The most significant scientific discovery of this century.” “The most interesting science book I’ve ever read. It has shown me that it’s still possible to establish something genuinely new in science.” Zhiliang Gong, University of Chicago. “The most significant scientific discovery of this century. What strikes me above all is the elegant simplicity of [Pollack’s] experimental approach. Many of the experiments can be done on the kitchen table, and you don’t even need a microscope to see the results.” Mae-Wan Ho, Author, Living Rainbow H2O; Director, Institute of Science and Society, London. “Dr. Pollack is one of the pioneers in this field, and his discoveries can be expected to have important implications.” Brian Josephson, Nobel Laureate, Cambridge University. “Fantastic material with revolutionary insights. What impresses me most is that the experiments are visually instantly accessible.” Helmut Roniger, Consulting physician “I blame Pollack for my chronic loss of sleep during the past week. Devouring his book has inspired in me a whole new burst of enthusiasm for science.” Jason Gillen, Massage therapist, Sydney Australia. “The most original thinker I have ever met.” Csaba Galambos, University of Colorado “Einstein has got nothing on Pollack. Pollack has the uncanny ability to pinpoint the right questions and grasp the simple ideas.” Capt. T.C. Randall, Author, Forbidden Healing “This is like getting new glasses! The clarity is astounding.” Charles Cushing, Independent Scientist “Unputdownable.” Nigel Dyer, University of Warwick, UK. “As good a page-turner as a Dan Brown novel. … this book has a folksy style that I know will be very popular.” David Anick, Harvard University “By Chapter 5 I was spellbound.