Neuroreceptor Activation by Vibration-Assisted Tunneling
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Quantum Biology: an Update and Perspective
quantum reports Review Quantum Biology: An Update and Perspective Youngchan Kim 1,2,3 , Federico Bertagna 1,4, Edeline M. D’Souza 1,2, Derren J. Heyes 5 , Linus O. Johannissen 5 , Eveliny T. Nery 1,2 , Antonio Pantelias 1,2 , Alejandro Sanchez-Pedreño Jimenez 1,2 , Louie Slocombe 1,6 , Michael G. Spencer 1,3 , Jim Al-Khalili 1,6 , Gregory S. Engel 7 , Sam Hay 5 , Suzanne M. Hingley-Wilson 2, Kamalan Jeevaratnam 4, Alex R. Jones 8 , Daniel R. Kattnig 9 , Rebecca Lewis 4 , Marco Sacchi 10 , Nigel S. Scrutton 5 , S. Ravi P. Silva 3 and Johnjoe McFadden 1,2,* 1 Leverhulme Quantum Biology Doctoral Training Centre, University of Surrey, Guildford GU2 7XH, UK; [email protected] (Y.K.); [email protected] (F.B.); e.d’[email protected] (E.M.D.); [email protected] (E.T.N.); [email protected] (A.P.); [email protected] (A.S.-P.J.); [email protected] (L.S.); [email protected] (M.G.S.); [email protected] (J.A.-K.) 2 Department of Microbial and Cellular Sciences, School of Bioscience and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK; [email protected] 3 Advanced Technology Institute, University of Surrey, Guildford GU2 7XH, UK; [email protected] 4 School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK; [email protected] (K.J.); [email protected] (R.L.) 5 Manchester Institute of Biotechnology, Department of Chemistry, The University of Manchester, -
Physics, Biology and the Origin of Life: the Physicians' View Geoffrey Goodman Phd1 and M
IMAJ • VOL 13 • DeceMber 2011 PERSPECTIVE Physics, Biology and the Origin of Life: The Physicians' View Geoffrey Goodman PhD1 and M. Eric Gershwin MD2 1Kfar Vradim, Israel 2Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA environment and were very much concerned with the insepa- ABSTRACT: Physicians have a great interest in discussions of life and its rable issue of 'what' is life and 'how' it relates to inanimate origin, including life's persistence through successive cycles matter. Physicians of those eras were more concerned about of self-replication under extreme climatic and man-made religion and the role of man and God than about physical sci- trials and tribulations. We review here the fundamental ence. One wonders what they would think today, with physical processes that, contrary to human intuition, life may be science dominated and puzzled by the apparent incompatibility seen heuristically as an ab initio, fundamental process between two fundamental concepts: general relativity (gravi- at the interface between the complementary forces of tational) theory that views matter-energy as an expression of gravitation and quantum mechanics. Analogies can predict a time-space continuum and quantum theory that considers applications of quantum mechanics to human physiology matter-energy in terms of discrete quantities (quanta) and in addition to that already being applied, in particular to waves and their counterintuitively weird behavior. The long- aspects of brain activity and pathology. This potential will also extend eventually to, for example, autoimmunity, held desire to unify these two fundamental laws of physics in genetic selection and aging. -
Adverse Reactions to Hallucinogenic Drugs. 1Rnstttutton National Test
DOCUMENT RESUME ED 034 696 SE 007 743 AUTROP Meyer, Roger E. , Fd. TITLE Adverse Reactions to Hallucinogenic Drugs. 1rNSTTTUTTON National Test. of Mental Health (DHEW), Bethesda, Md. PUB DATP Sep 67 NOTE 118p.; Conference held at the National Institute of Mental Health, Chevy Chase, Maryland, September 29, 1967 AVATLABLE FROM Superintendent of Documents, Government Printing Office, Washington, D. C. 20402 ($1.25). FDPS PRICE FDPS Price MFc0.50 HC Not Available from EDRS. DESCPTPTOPS Conference Reports, *Drug Abuse, Health Education, *Lysergic Acid Diethylamide, *Medical Research, *Mental Health IDENTIFIEPS Hallucinogenic Drugs ABSTPACT This reports a conference of psychologists, psychiatrists, geneticists and others concerned with the biological and psychological effects of lysergic acid diethylamide and other hallucinogenic drugs. Clinical data are presented on adverse drug reactions. The difficulty of determining the causes of adverse reactions is discussed, as are different methods of therapy. Data are also presented on the psychological and physiolcgical effects of L.S.D. given as a treatment under controlled medical conditions. Possible genetic effects of L.S.D. and other drugs are discussed on the basis of data from laboratory animals and humans. Also discussed are needs for futher research. The necessity to aviod scare techniques in disseminating information about drugs is emphasized. An aprentlix includes seven background papers reprinted from professional journals, and a bibliography of current articles on the possible genetic effects of drugs. (EB) National Clearinghouse for Mental Health Information VA-w. Alb alb !bAm I.S. MOMS Of NAM MON tMAN IONE Of NMI 105 NUNN NU IN WINES UAWAS RCM NIN 01 NUN N ONMININI 01011110 0. -
Molecular Mechanisms of Addiction
Molecular Mechanisms of Addiction Eric J. Nestler Nash Family Professor The Friedman Brain Institute Medical Model of Addiction • Pathophysiology - To identify changes that drugs produce in a vulnerable brain to cause addiction. • Individual Risk - To identify specific genes and non-genetic factors that determine an individual’s risk for (or resistance to) addiction. - About 50% of the risk for addiction is genetic. Only through an improved understanding of the biology of addiction will it be possible to develop better treatments and eventually cures and preventive measures. Scope of Drug Addiction • 25% of the U.S. population has a diagnosis of drug abuse or addiction. • 50% of U.S. high school graduates have tried an illegal drug; use of alcohol and tobacco is more common. • >$400 billion incurred annually in the U.S. by addiction: - Loss of life and productivity - Medical consequences (e.g., AIDS, lung cancer, cirrhosis) - Crime and law enforcement Diverse Chemical Substances Cause Addiction • Opiates (morphine, heroin, oxycontin, vicodin) • Cocaine • Amphetamine and like drugs (methamphetamine, methylphenidate) • MDMA (ecstasy) • PCP (phencyclidine or angel dust; also ketamine) • Marijuana (cannabinoids) • Tobacco (nicotine) • Alcohol (ethanol) • Sedative/hypnotics (barbiturates, benzodiazepines) Chemical Structures of Some Drugs of Abuse Cocaine Morphine Ethanol Nicotine ∆9-tetrahydrocannabinol Drugs of Abuse Use of % of US population as weekly users 100 25 50 75 0 Definition of Drug Addiction • Loss of control over drug use. • Compulsive drug seeking and drug taking despite horrendous adverse consequences. • Increased risk for relapse despite years of abstinence. Definition of Drug Addiction • Tolerance – reduced drug effect after repeated use. • Sensitization – increased drug effect after repeated use. -
Vol. 85 Tuesday, No. 67 April 7, 2020 Pages 19375–19640
Vol. 85 Tuesday, No. 67 April 7, 2020 Pages 19375–19640 OFFICE OF THE FEDERAL REGISTER VerDate Sep 11 2014 21:02 Apr 06, 2020 Jkt 250001 PO 00000 Frm 00001 Fmt 4710 Sfmt 4710 E:\FR\FM\07APWS.LOC 07APWS khammond on DSKJM1Z7X2PROD with FR-1WS II Federal Register / Vol. 85, No. 67 / Tuesday, April 7, 2020 The FEDERAL REGISTER (ISSN 0097–6326) is published daily, SUBSCRIPTIONS AND COPIES Monday through Friday, except official holidays, by the Office PUBLIC of the Federal Register, National Archives and Records Administration, under the Federal Register Act (44 U.S.C. Ch. 15) Subscriptions: and the regulations of the Administrative Committee of the Federal Paper or fiche 202–512–1800 Register (1 CFR Ch. I). The Superintendent of Documents, U.S. Assistance with public subscriptions 202–512–1806 Government Publishing Office, is the exclusive distributor of the official edition. Periodicals postage is paid at Washington, DC. General online information 202–512–1530; 1–888–293–6498 Single copies/back copies: The FEDERAL REGISTER provides a uniform system for making available to the public regulations and legal notices issued by Paper or fiche 202–512–1800 Federal agencies. These include Presidential proclamations and Assistance with public single copies 1–866–512–1800 Executive Orders, Federal agency documents having general (Toll-Free) applicability and legal effect, documents required to be published FEDERAL AGENCIES by act of Congress, and other Federal agency documents of public Subscriptions: interest. Assistance with Federal agency subscriptions: Documents are on file for public inspection in the Office of the Federal Register the day before they are published, unless the Email [email protected] issuing agency requests earlier filing. -
Quantum Microbiology
Curr. Issues Mol. Biol. 13: 43-50. OnlineQuantum journal at http://www.cimb.orgMicrobiology 43 Quantum Microbiology J. T. Trevors1* and L. Masson2* big bang. Currently, one of the signifcant unsolved problems in modern physics is how to merge the two into a unifying 1School of Environmental Sciences, University of Guelph, theory. Since quantum mechanics describes the physical 50 Stone Rd., East, Guelph, Ontario N1G 2W1, Canada world, and living organisms are physical entities, it is rational 2Biotechnology Research Institute, National Research and logical to examine the role of quantum mechanics in Council of Canada, 6100 Royalmount Ave., Montreal, the matter and energy of living microorganisms, especially Quebec H4P 2R2, Canada their origin about 4 billion years ago. To do so requires an understanding of quantum processes at the atomic scale and smaller where electrons, for example, do not collide Abstract with the atomic nucleus but defy electromagnetism and orbit During his famous 1943 lecture series at Trinity College at both an undefned speed and path around the nucleus. Dublin, the reknown physicist Erwin Schrödinger discussed One distinguishing characteristic of quantum mechanics the failure and challenges of interpreting life by classical is the Complementarity Principle (or wave-particle duality) physics alone and that a new approach, rooted in Quantum developed by Niels Bohr indicating that a particle can principles, must be involved. Quantum events are simply a possess multiple contradictory properties. level of organization below the molecular level. This includes A classic example of complementarity is Thomas the atomic and subatomic makeup of matter in microbial Young's famous light interference, and later on the double- metabolism and structures, as well as the organic, genetic slit, experiment showing that light or other quantum information codes of DNA and RNA. -
Plants Can Grow Quickly Or Ward Off Hungry Insects, but Not Both Plant's Ability to Identify, Block Invading Bacteria Examined
Plants Can Grow Quickly or Ward Off Hungry Insects, but Not Both Mar.29, 2010 in Botany, Nature, Science and Technology Leave a Comment Plant-eating insects such as this silhouetted caterpillar have played a pivotal role in the evolution of plants. (Credit: Photo by Ellen Woods, Cornell University) ScienceDaily (Mar. 27, 2010) — There's a war occurring each day in our backyards — plant versus plant-eating insect versus insect-eating insect. Research by UC Irvine's Kailen Mooney suggests the outcome [...] Plant’s Ability to Identify, Block Invading Bacteria Examined Mar.22, 2010 in Botany, Nature, Science and Technology Leave a Comment This is a flower of the Arabidopsis thaliana plant. (Credit: (USDA-Agriculture Research Service photo by Peggy Greb).) ScienceDaily (Mar. 21, 2010) — Understanding how plants defend themselves from bacterial infections may help researchers understand how people and other animals could be better protected from such pathogens. That's the idea behind a study to observe a [...] How Plants Put Down Roots: Geneticists Research Organ Development in the Plant Embryo Mar.17, 2010 in Botany, Science and Technology Leave a Comment One week old seed of the thale cress with embryo. (Credit: Martin Bayer / Max Planck Institute for Developmental Biology) ScienceDaily (Mar. 16, 2010) — In the beginning is the fertilized egg cell. Following numerous cell divisions, it then develops into a complex organism with different organs and tissues. The largely unexplained process whereby the [...] Can a Single Layer of Cells Control a Leaf’s Size? Mar.15, 2010 in Botany, Science and Technology Leave a Comment ScienceDaily (Mar. -
Energy and Epigenetics: Quantum Cell Theory, Life As a Collective Phenomena
Energy and Epigenetics: Quantum Cell Theory, Life as a Collective Phenomena 1. How is life brought to life? 2. What is a SQUID? 3. Does physics direct biology? 4. What is the field effect? 5. What is quantum cell theory and how does it work? This will probably be the most important blog in the entire Quilt. It is how I see the three fundamental laws of nature integrating and coordinating the physiologic function animating life. It is how all life works as a collective phenomena under the electromagnetic force. It is loaded with science, and it may be a hard read for some, but ask questions. If you do not, you might never get to optimal. This blog contains my holy grail in how I figured out how to get me healthy. I remember the day I wrote it in 2007 like it was yesterday. I would strongly recommend clicking and reading every hyperlink in this blog. It will help you understand things more fully. In this blog, you will see how light, water and the electromagnetic field form a Superconducting Quantum Interference Device (SQUID) on the surface of your brain that allows you to be human. SQUID‘S are important in the mammalian neocortex because they are able to switch signals from one neural circuit to another, at extremely high speeds, while storing massive amounts of information, all while using very low power dissipation. We are part of an electric universe. This all can be done in the tightest of quarters. This works at nanoscopic levels on semiconductor chips in your laptop and in the subarachnoid space of your brain. -
Novel Hallucinogens and Plant-Derived Highs
Novel Hallucinogens and Plant-Derived Highs Emily Dye Forensic Chemist Special Testing and Research Laboratory Drug Enforcement Administration Outline • Hallucinogens • Plant-Derived Highs – 2C Compounds – Kratom – NBOMe Compounds – Fly Agaric Mushrooms – DOX Compounds – Kava Kava – Kanna • Empathogens – Aminoindanes – APDB – APB DEA Special Testing and Research Laboratory Emerging Trends Program 2C Compounds • Psychedelic phenethylamines • Synthesized by Alexander Shulgin – Published in PiHKAL • 27 known compounds – Most common: 2C-C, 2C-B, and 2C-I DEA Special Testing and Research Laboratory Emerging Trends Program 2C Compounds DEA Special Testing and Research Laboratory Emerging Trends Program 2C-B-FLY • Psychedelic phenethylamine • Synthesized by Aaron Monte www.erowid.org DEA Special Testing and Research Laboratory Emerging Trends Program Bromo-DragonFLY • Psychedelic phenethylamine • Synthesized in the lab of David Nichols • Deaths associated with misrepresentation as 2C-B-FLY www.erowid.org DEA Special Testing and Research Laboratory Emerging Trends Program NBOMe Compounds • Hallucinogenic phenethylamines • Synthesized by Heim, et al. • Isomers can be distinguished via RT and MS DEA Special Testing and Research Laboratory Emerging Trends Program Name R1 R2 R3 R4 Name R1 R2 R3 R4 25B-NB2OMe Br OCH3 H H 25N-NB2OMe NO2 OCH3 H H 25B-NB3OMe Br H OCH3 H 25N-NB3OMe NO2 H OCH3 H 25B-NB4OMe Br H H OCH3 25N-NB4OMe NO2 H H OCH3 25C-NB2OMe Cl OCH3 H H 25P-NB2OMe CH2CH2CH3 OCH3 H H 25C-NB3OMe Cl H OCH3 H 25P-NB3OMe CH2CH2CH3 H OCH3 H 25C-NB4OMe -
Download Thesisadobe
Non-targeted analysis of new psychoactive substances using mass spectrometric techniques by Daniel J. Pasin, MRACI A thesis submitted for the Degree of Doctor of Philosophy (Science) University of Technology Sydney 2018 Certificate of authorship and originality I certify that the work in this thesis has not previously been submitted for a degree nor has it been submitted as part of the requirements for a degree except as fully acknowledged within the text. I also certify that the thesis has been written by me. Any help that I have received in my research work and the preparation of the thesis itself has been acknowledged. In addition, I certify that all the information sources and literature used are indicated in the thesis. This research is supported by an Australian Government Research Training Program Scholarship. Production Note: Signature removed prior to publication. Daniel J. Pasin, MRACI 26/02/2018 Acknowledgements Acknowledgements Firstly, I would like to extend my deepest thanks to my primary supervisor, Associate Professor Shanlin Fu. You have been my primary supervisor for both my honours and PhD degrees and over these last 5 years, you have been nothing but supportive, patient and encouraging. I could always rely on you to provide timely feedback and you were always happy to endorse me for post-PhD opportunities. It has been a great pleasure to complete my PhD research under your supervision. I would also like to thank my co-supervisors, Dr. Adam Cawley and Dr. Sergei Bidny. Without your external collaboration, the success of this project could not be possible. Furthermore, I wish to acknowledge the staff at the Australian Racing Forensic Laboratory (ARFL) and Forensic Toxicology Laboratory at NSW FASS for your assistance in this project. -
On Certain Issues of Export and Import Licensing of Goods
ON CERTAIN ISSUES OF EXPORT AND IMPORT LICENSING OF GOODS The Government of the Republic of Kazakhstan of 12 June 2008, No. 578 _________________________________________________________ Footnote. Title as amended by the Resolution of the Government of the Republic of Kazakhstan of 17 October 2012, No. 1320 (entered into force upon the expiration of twenty-one calendar days after the first official publication). In order to implement the laws of the Republic of Kazakhstan "On State Regulating of Production and Turnover of Ethyl Spirits and Alcohol Products" of 16 July 1999, "On Licensing" of 11 January 2007 and "On Export Control» of 21 July 2007 the Government of the Republic of Kazakhstan HAS DECIDED: Footnote. Preamble, as amended by the Resolution of the Government of the Republic of Kazakhstan from 18 September 2008, No. 861. 1. To approve the attached: 1) excluded by the Resolution of the Government of Kazakhstan of 17 October 2012, No. 1320; 2) The qualification requirements for export and import licensing of goods; 3) The list of goods, export and (or) import subject to licensing; 4) The application form for a license and (or) annexes to a license; 5) forms of licenses and annexes to licenses. Footnote. Paragraph 1, as amended by the Resolution of the Government of the Republic of Kazakhstan 17 October 2012, No.1320. 2. Declare invalid certain Resolutions of the Government of the Republic of Kazakhstan in accordance with the Annex to this Resolution. 3. This Resolution shall come into force upon the expiration of twenty-one calendar days after its official publication. Premier of the Republic of Kazakhstan Karim Massimov Approved by the Resolution of the Government of the Republic of Kazakhstan of 12 June 2008, No.578 The Rules on Export and Import Licensing, Including Licensing of Goods Subject to Export Controls, and Rules on Automatic Import Licensing of Certain Goods Footnote. -
The Role of Norepinephrine in the Pharmacology of 3,4
!"#$%&'#$&($)&*#+,-#+"*,-#$,-$."#$/"0*102&'&34$&($ 56789#."4'#-#:,&;41#."01+"#.01,-#$<9=9>6$?#[email protected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`,E#-E$ I0--$ D-.#*$ 2*#0.,J#2&11&-@X&*3a',2#-2#@aY48-28 -:aSX]a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