Negative Pathogens from Hospital-Acquired Pneumonia in the UK and Ireland Since 2011 Beate Ritz*1, Nowel Redder1, Nathalie Dunkel1

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Negative Pathogens from Hospital-Acquired Pneumonia in the UK and Ireland Since 2011 Beate Ritz*1, Nowel Redder1, Nathalie Dunkel1

P1865 Susceptibility of ceftobiprole and other beta-lactams against Gram- negative pathogens from hospital-acquired pneumonia in the UK and Ireland since 2011 Beate Ritz*1, Nowel Redder1, Nathalie Dunkel1 1 Correvio, Geneva, Switzerland Background: Ceftobiprole, an advanced-generation cephalosporin has been approved since 2013 in the United Kingdom and other European countries for the treatment of community- and hospital-acquired pneumonia (HAP) (excluding ventilator-associated pneumonia). BSAC respiratory surveillance programme includes ceftobiprole since 2011. Materials/methods: Gram-negative pathogens causing HAP were collected as part of the BSAC respiratory surveillance programme between 2011-12 to 2016-17. In total 1290 Escherichia coli, 789 Klebsiella pneumoniae and 1059 Pseudomonas aeruginosa were tested using the BSAC agar dilution method and susceptibility determined according to EUCAST breakpoints. Results: Virtually all E. coli and K. pneumoniae tested were susceptible to meropenem whereas the other beta- lactams tested had similar in vitro efficacy with the exception of amoxicillin/clavulanic acid. Meropenem had the lowest susceptibility to P. aeruginosa followed by ceftobiprole, piperacillin/tazobactam and ceftazidime. K. P. E. coli pneumoniae aeruginosa Range MIC50 MIC90 %S Range MIC50 MIC90 %S Range MIC50 0.03- 0.03- 0.25- BPR 0.06 16 86.0 0.06 64 83.3 2 512 512 512 0.5- 0.25- AMC 16 128 47.5 2 64 76.7 NA NA 128 128 0.03- 0.03- 0.06- CAZ 0.25 4 85.5 0.25 16 84.0 2 256 512 512 0.125- 0.25- 0.125- TZP 2 16 88.9 4 32 81.5 4 512 512 512 0.008- 0.008- 0.032- MEM 0.016 0.032 100 0.032 0.032 98.8 0.25 0.125 512 64 *based on EUCAST PK/PD non-species specific susceptibility breakpoint of 4 mg/L; BPR: ceftobiprole; AMC: amoxicillin/clavulanic acid; CAZ: ceftazidime; TZP: piperacillin/tazobactam; MEM: meropenem Conclusions: On this large collection of Gram-negative pathogens, E. coli, K, pneumoniae and P. aeruginosa showed high and consistent susceptibility to ceftobiprole . Both E. coli and K. pneumoniae had similar susceptibility rates to ceftobiprole, ceftazidime or piperacillin/tazobactam. For P. aeruginosa, susceptibility rates were similar between meropenem, ceftobiprole and piperacillin/tazobactam. In this study, ceftazidime showed the highest in vitro efficacy against P. aeruginosa. Acknowledgments: Data were collected by BSAC as part of its Respiratory Surveillance Programme and are available online at www.bsacsurv.org. 29TH ECCMID 13-16 APRIL 2019 AMSTERDAM, NETHERLANDS POWERED BY M-ANAGE.COM .

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1072 ICAAC Fritschen MW08 F
POSTER E-0115 Thomas R. Fritsche, MD, PhD In-vitro Activity of Ceftobiprole Tested Against a Recent Collection of JMI Laboratories ICAAC 2006 345 Beaver Kreek Centre, Suite A North American Pseudomonas aeruginosa North Liberty, IA 52317 Tel: (319) 665-3370 T.R. Fritsche, H.S. Sader, R.N. Jones • JMI Laboratories, North Liberty, Iowa, USA Fax: (319) 665-3371 e-mail: [email protected] Introduction Results Updated Abstract Table 1. In-vitro activity of ceftobiprole in comparison to selected antimicrobial agents tested against 221 isolates of P. aeruginosa Ceftobiprole (previously known as BAL9141), is an investigational broad- (North America) • P. aeruginosa isolates recovered from patients in North America generally Background: Ceftobiprole (BAL9141; BPR) is an investigational spectrum cephalosporin with potent activity against both Gram-negative and displayed less antibiotic resistance than did isolates from the all-isolate Antimicrobial agent MIC (µg/ml) MIC (µg/ml) Range (µg/ml) % Susceptible/resistanta cephalosporin with a broad spectrum of activity including methicillin- Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus 50 90 worldwide collection (examples: tobramycin, 3.6 and 20.8% resistance, resistant S. aureus. PK/PD characteristics of the parenteral prodrug (MRSA) (3, 7-9). The agent is stable to many β-lactamases and has a Ceftobiprole 2 >8 ≤0.06 – >8 - / - respectively; imipenem, 5.9 and 11.6%; Tables 1 and 2). formulation are consistent with usable potencies against streptococci, Ceftazidime 2 >16 ≤1 – >16 78.7 / 15.8 strong affinity for penicillin binding proteins (PBPs), including PBP2a, which • Ceftobiprole was as active as ceftazidime and cefepime (MIC , 2 µg/ml) E.
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Ceftobiprole
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1 Summary of Product Characteristics
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