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Boletín De Pasuchaca Patentes Extranjeras BOLETÍN DE PASUCHACA Septiembre 2014 PATENTES EXTRANJERAS Número de solicitud: JP200173253A Título: COMPOSITION FOR ENHANCING GLTATHIONE | The composition for a glutathione increase|augmentation Fecha de solicitud: 2001-03-15 Solicitante: FANCL CORP Abstract: Compositions for increasing glutathione are new. Compositions for increasing glutathione contain at least one of Filipendula ulmaria, Valeriana fauriei, Sanbucus nigra, Granium dielsianum, Carthamus tinctorius, Foeniculum vulgare, Eriobotrya japonica, Phyllostachys bambusoides, Coriandrum sativum, Satureja hortensis, Zanthoxylum piperitum, Eucommia ulmoides, Olea europaea, Camellia japonica, Agaricus blasei, Actinidia polygama, Glehnia littoralis, Althaea rosea, Crataegus cuneate, Coixlachryma- jobi, Centaurea cyanus, Gentianella alborocea, Allium cepa, Sesamum indicum, Illicium verum, Anethum graveolens, Beta vulgaris, Trigonella foenum-graecum, Lonicera caerulea, Glycine max, Lactuca formosana, Lepidiemmeyenii, Malva sylvestris, Dioscorea batatas, Phaseolus vulgaris, Allium fistulosum, Capsicum annuum, Brassica oleracea, and Cannabis sativa. The compositions are useful as foods and pharmaceuticals especially for liver diseases, e.g., alcoholic liver disease, pulmonary diseases, and cataracts. The compositions increase supply of glutathione in vivo, and the glutathione increasing activity largely increases when using with cysteine. Número de solicitud: JP2002241369A Título: AGENT FOR INHIBITING DIFFERENTIATION OF LIPOCYTE | Fat-cell differential inhibition agent Fecha de solicitud: 2002-08-22 Solicitante: FANCL CORP Abstract: A differential inhibition agent of precursor fat cell contains mushroom, Trametes versicolor, Valeriana, Jacaranda copaia, Pasuchaca, Chenopodium ambrosioides, Berberis vulgaris, cammomile, guava leaf, kaffir lime, juniper berry, nutmeg, basil, mace, lemon grass, rosemary, leaf of persimmon, Gymnema sylvestre, Cyclocarya paliurus and lemon verbena. A differential inhibition agent of precursor fat cell contains mushroom, Trametes versicolor, Valeriana, Jacaranda copaia, Pasuchaca, Chenopodium ambrosioides, Berberis vulgaris, Zeodoriae rhizome, cammomile, Kumazasa , guava leaf, kaffir lime, juniper berry, nutmeg, basil, lemon grass, rosemary, leaf of persimmon, Gymnema sylvestre , Cyclocarya paliurus and lemon verbena. INDEPENDENT CLAIMS are also included for the following: lipid-storage inhibitor of fat cells which contains mushroom plant; antiobesity agent; composition for antiobesity; cellulitis improving agent; andfoodstuffs, pharmaceutical and cosmetics. Anorectic. No suitable test details are given None Given. For use in foodstuffs, pharmaceutical and cosmetics for preventing obesity. The differential inhibition agent prevents accumulation of excess fat of whole body and/or a part of body, and suppresses mature fat cell number. The fat-cell differential inhibition agent is highly safe. Número de solicitud: JP2006256710A Título: COMPOSITION FOR ENHANCING GLUTATHIONE | The composition for a glutathione increase|augmentation Fecha de solicitud: 2006-09-22 Solicitante: FANCL CORP Abstract: A composition for augmenting glutathione comprises plants of e.g. meadowsweet, Valeriana, Sanbucus nigra, Pasuchaca, safflower, fennel, loquat, bamboo, coriander, olive, Camellia japonica, Agaricus, silvervine, Glehnia littoralis, dill, Beta vulgaris, Trigonella foenum graecum, Lonicera caerulea L.var, soybeans, Taiwan Ixeris dentata, maca, mallow, Chinese yam, kidney bean, Welsh onion, green pepper and/or broccoli. A composition for augmenting glutathione comprises plants of meadowsweet (Filipendula ulmaria ), Valeriana, Sanbucus nigra, Pasuchaca, safflower, fennel, loquat, bamboo, coriander, Satureja hortensis, Japanese pepper, Eucommia ulmoides, olive, Camellia japonica, Agaricus, silvervine, Glehnia littoralis, althea, hawthorn, Coix lacryma-jobi, Centaurea cyanus, Hercampuri, onion, sesame, anisi steilati fructus, dill, Beta vulgaris , Trigonella foenum graecum, Lonicera caerulea L.var, soybeans, Taiwan Ixeris dentata, maca, mallow, Chinese yam, kidney bean, Welsh onion, green pepper, hemp and/or broccoli. An INDEPENDENT CLAIM is included for a supplement, functional food and health food containing the composition for augmenting 1 BOLETÍN DE PASUCHACA Septiembre 2014 lutathione. Hepatotropic; Respiratory-Gen.; Ophthalomological; Dermatological; Immunosuppressive; Antiallergic; Anti-HIV; Cardiant; Vasotropic; Neuroprotective Cerebroprotective; Nootropic; Antiparkinsonian; Antidiabetic; Nephrotropic; Hypotensive; Anorectic; Antiarteriosclerotic; Virucide; Antiulcer; Gastrointestinal-Gen. Glutathione-Agonist.The effect of plants to augment the glutathione amount was evaluated using CCD1059 normal human skin fibroblast cell. The cells were inoculated in DMEM culture medium containing 10% fetal bovine serum. The cells were cultivated for 3 days at 37°C under 5% carbon dioxide. The culture medium was removed and plant extracts were added and again cultivated for 24 hours. Then, Nacetyl cysteine was added and the combined effect was measured. The result showed that the combination of plant extract and the N-acetyl cysteine enhanced the glutathione content in the fibroblast cells. For treating and preventing diseases caused due to lack of glutathione and oxidative stress such as liver disease and diseases caused due to the accumulation of peroxylipid such as pulmonary disorders, cataract and aging, as a component for anti-UV rays and skin whitening (claimed) and also useful for treating immunological diseases, hepatopathy due to radiation, drug and heavy metal, allergic disease, acquired immune deficiency syndrome, ischemic heart disease, neurodegenerative disease such as cerebral ischemia, amyotrophic lateral sclerosis, Alzheimers disease, Parkinsons disease, Huntingtons disease, adult respiratory distress syndrome, diabetes, nephrosis, hypertension, obesity, atherosclerosis, latent viral infectious disease and gastric ulcer. The plant efficiently promotes intracellular concentration of glutathione in each organ such as kidney, liver, lungs, skin and brain and is highly safe to use. Preferred Components: The composition further comprises protein and/or yeast that are rich cysteine. Número de solicitud: JP2006256709A Título: COMPOSITION FOR ENHANCING GLUTATHIONE | The composition for a glutathione increase|augmentation Fecha de solicitud: 2006-09-22 Solicitante: FANCL CORP Abstract: A composition for augmenting glutathione comprises plants of e.g. meadowsweet, Valeriana, Sanbucus nigra, Pasuchaca, safflower, fennel, loquat, bamboo, coriander, olive, Camellia japonica, Agaricus, silvervine, Glehnia littoralis, dill, Beta vulgaris, Trigonella foenum graecum, Lonicera caerulea L.var, soybeans, Taiwan Ixeris dentata, maca, mallow, Chinese yam, kidney bean, Welsh onion, green pepper and/or broccoli. A composition for augmenting glutathione comprises plants of meadowsweet (Filipendula ulmaria), Valeriana, Sanbucus nigra, Pasuchaca, safflower, fennel, loquat, bamboo, coriander, Satureja hortensis, Japanese pepper, Eucommia ulmoides, olive, Camellia japonica, Agaricus, silvervine, Glehnia littoralis, althea, hawthorn, Coix lacryma-jobi, Centaurea cyanus, Hercampuri, onion, sesame, anisi steilati fructus, dill, Beta vulgaris, Trigonella foenum graecum, Lonicera caerulea L.var, soybeans, Taiwan Ixeris dentata, maca, mallow, Chinese yam, kidney bean, Welsh onion, green pepper, hemp and/or broccoli. An INDEPENDENT CLAIM is included for a supplement, functional food and health food containing the composition for augmenting glutathione. Hepatotropic; Respiratory-Gen.; Ophthalomological; Dermatological; Immunosuppressive; Antiallergic; Anti-HIV; Cardiant; Vasotropic; Neuroprotective Cerebroprotective; Nootropic; Antiparkinsonian; Antidiabetic; Nephrotropic; Hypotensive; Anorectic; Antiarteriosclerotic; Virucide; Antiulcer; Gastrointestinal-Gen. Glutathione-Agonist.The effect of plants to augment the glutathione amount was evaluated using CCD1059 normal human skin fibroblast cell. The cells were inoculated in DMEM culture medium containing 10% fetal bovine serum. The cells were cultivated for 3 days at 37°C under 5% carbon dioxide. The culture medium was removed and plant extracts were added and again cultivated for 24 hours. Then, N-acetyl cysteine was added and the combined effect was measured. The result showed that the combination of plant extract and the N-acetyl cysteine enhanced the glutathione content in the fibroblast cells. For treating and preventing diseases caused due to lack of glutathione and oxidative stress such as liver disease and diseases caused due to the accumulation of peroxylipid such as pulmonary disorders, cataract and aging, as a component for anti-UV rays and skin whitening (claimed) and also useful for treating immunological diseases, hepatopathy due to radiation, drug and heavy metal, allergic disease, acquired immune deficiency syndrome, ischemic heart disease, neurodegenerative disease such as cerebral ischemia, amyotrophic lateral sclerosis, Alzheimers disease, Parkinsons disease, Huntingtons disease, adult respiratory distress syndrome, diabetes, nephrosis, hypertension, obesity, atherosclerosis, latent viral infectious disease and gastric ulcer. The plant efficiently promotes intracellular concentration of glutathione in each organ such as kidney, liver, lungs, skin and brain and is highly safe to use. Preferred Components: The composition further comprises protein and/or yeast that are rich cysteine. 2 BOLETÍN DE PASUCHACA Septiembre 2014
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