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Wellcome Trust Annual Report and Financial Statements 2017 Contents
Annual Report and Financial Statements 2017 2 Wellcome Trust Annual Report and Financial Statements 2017 Contents Report from the Chair and the Director 5 Trustee’s Report 8 What we do 8 Review of Charitable Activities 9 Review of Investment Activities 18 Financial Review 29 Structure and Governance 34 Risk Management 37 Remuneration Report 40 Audit Committee Report 43 Independent Auditor’s Report 45 Financial Statements 58 Consolidated Statement of Financial Activities 58 Consolidated Balance Sheet 59 Statement of Financial Activities of the Trust 60 Balance Sheet of the Trust 61 Consolidated Cash Flow Statement 62 Notes to the Financial Statements 63 Reference and Administrative Details 117 3 Wellcome Trust Annual Report and Financial Statements 2017 “ At Wellcome, we believe in the power of ideas to improve health” Jeremy Farrar Director 4 Wellcome Trust Annual Report and Financial Statements 2017 Report from the Chair and the Director “Our core approach is funding people to explore great ideas, at every step of the way from discovery to impact” At Wellcome, we believe in the power of ideas to improve cause of maternal mortality in the world. It also includes health. Funded from our independent investment portfolio, supporting research in the humanities and social sciences, we support thousands of scientists and researchers in more such as a project which this year published ethical guidelines than 70 countries, as well as innovators, educators and artists. for involving pregnant women in Zika vaccine research. Together, we take on big problems, fuel imaginations and spark And resources like the Human Induced Pluripotent Stem Cell debate, working always to achieve better health for everyone. -
Julia M Yeomans FRS Department of Physics Address: Rudolf Peierls
Julia M Yeomans FRS Department of Physics Address: Rudolf Peierls Centre for Theoretical Physics, 1 Keble Road, Oxford OX1 3NP, UK Telephone: 44 (0)1865 273992 Fax: 44 (0)1865 273947 Email: [email protected] Home page: http://www-thphys.physics.ox.ac.uk/people/JuliaYeomans Nationality: British Family: Married, 4 daughters Qualifications: Diploma, Teaching and Learning in Higher Education (Oxford University) 2000. D. Phil.Thesis, Critical Phenomena of Disordered Systems (Oxford University) 1979. B.A. Physics, First class honours (Oxford University), 1976. Positions held: 2002 { Professor of Physics, University of Oxford 1998 { 02 Reader in Physics, University of Oxford 1995 { 98 University Lecturer, University of Oxford 1983 { Pauline Chan Fellow and Tutor in Physics, St. Hilda's College, Oxford 1981 { 83 Lecturer, Department of Physics, Southampton University 1979 { 81 Postdoctoral Research Associate, Cornell University, USA Visiting positions: 2014 Kavli Institute for Theoretical Physics, Santa Barbara, USA 2013 Visiting Fellowship, Newton Institute, Cambridge 2011 Visiting Professor, Enhanced Education Programme, University of Kyushu, Japan 1995 Visiting Professor, University of Padua, Italy 1992 Visiting Professor, Catholic University of Leuven Distinctions: Ehrenfest Colloquium, Leiden, 2017 Vice Chair, Gordon Conference on Complex Active and Adaptive Matter, California, 2017 Guest of Honor, 115th Statistical Physics Conference, Rutgers, 2016 Elected Fellow of the Royal Society, 2013 3rd EPJE-de Gennes Prize lecture, 2013 -
The Electron Microscopy Science Technology Platform at the Francis
The Francis Crick Institute is a The Electron biomedical discovery institute Microscopy dedicated to understanding the fundamental biology underlying Science health and disease. Its work Technology is helping to understand why disease develops and to translate Platform at discoveries into new ways to the Francis prevent, diagnose and treat illnesses such as cancer, heart Crick Institute disease, stroke, infections, and Lucy Collinson neurodegenerative diseases. An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, University College London, Imperial College London and King’s College London. The Crick was formed in 2015, with many of the Crick’s scientists joining from two ‘parent’ institutes, the MRC’s National Institute for Medical Research and Cancer Research UK’s London Research Institute, and in 2016 it moved into a brand new state-of- the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe. © Nick Guttridge 4 ISSUE 46 JUNE 2017 5 Each microscope room is a six-sided shielded box, • The Phenom-World DelPhi benchtop SEM with walls that contain complex metallic layers has an integrated fluorescence microscope to attenuate DC fields, and an active cancellation for correlative imaging system to attenuate AC fields. Under each • The FEI Twin 120 kV TEM has a cryo stage for microscope is a concrete platform, cast in place, and screening vitrified macromolecular samples supported by air springs that remove environmental prior to imaging on 200 kV and 300 kV TEMs vibration to <1 Hz. -
Structure of Human Aspartyl Aminopeptidase Complexed With
Chaikuad et al. BMC Structural Biology 2012, 12:14 http://www.biomedcentral.com/1472-6807/12/14 RESEARCH ARTICLE Open Access Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family Apirat Chaikuad1, Ewa S Pilka1, Antonio De Riso2, Frank von Delft1, Kathryn L Kavanagh1, Catherine Vénien-Bryan2, Udo Oppermann1,3 and Wyatt W Yue1* Abstract Backround: Aspartyl aminopeptidase (DNPEP), with specificity towards an acidic amino acid at the N-terminus, is the only mammalian member among the poorly understood M18 peptidases. DNPEP has implicated roles in protein and peptide metabolism, as well as the renin-angiotensin system in blood pressure regulation. Despite previous enzyme and substrate characterization, structural details of DNPEP regarding ligand recognition and catalytic mechanism remain to be delineated. Results: The crystal structure of human DNPEP complexed with zinc and a substrate analogue aspartate-β- hydroxamate reveals a dodecameric machinery built by domain-swapped dimers, in agreement with electron microscopy data. A structural comparison with bacterial homologues identifies unifying catalytic features among the poorly understood M18 enzymes. The bound ligands in the active site also reveal the coordination mode of the binuclear zinc centre and a substrate specificity pocket for acidic amino acids. Conclusions: The DNPEP structure provides a molecular framework to understand its catalysis that is mediated by active site loop swapping, a mechanism likely adopted in other M18 and M42 metallopeptidases that form dodecameric complexes as a self-compartmentalization strategy. Small differences in the substrate binding pocket such as shape and positive charges, the latter conferred by a basic lysine residue, further provide the key to distinguishing substrate preference. -
Female Fellows of the Royal Society
Female Fellows of the Royal Society Professor Jan Anderson FRS [1996] Professor Ruth Lynden-Bell FRS [2006] Professor Judith Armitage FRS [2013] Dr Mary Lyon FRS [1973] Professor Frances Ashcroft FMedSci FRS [1999] Professor Georgina Mace CBE FRS [2002] Professor Gillian Bates FMedSci FRS [2007] Professor Trudy Mackay FRS [2006] Professor Jean Beggs CBE FRS [1998] Professor Enid MacRobbie FRS [1991] Dame Jocelyn Bell Burnell DBE FRS [2003] Dr Philippa Marrack FMedSci FRS [1997] Dame Valerie Beral DBE FMedSci FRS [2006] Professor Dusa McDuff FRS [1994] Dr Mariann Bienz FMedSci FRS [2003] Professor Angela McLean FRS [2009] Professor Elizabeth Blackburn AC FRS [1992] Professor Anne Mills FMedSci FRS [2013] Professor Andrea Brand FMedSci FRS [2010] Professor Brenda Milner CC FRS [1979] Professor Eleanor Burbidge FRS [1964] Dr Anne O'Garra FMedSci FRS [2008] Professor Eleanor Campbell FRS [2010] Dame Bridget Ogilvie AC DBE FMedSci FRS [2003] Professor Doreen Cantrell FMedSci FRS [2011] Baroness Onora O'Neill * CBE FBA FMedSci FRS [2007] Professor Lorna Casselton CBE FRS [1999] Dame Linda Partridge DBE FMedSci FRS [1996] Professor Deborah Charlesworth FRS [2005] Dr Barbara Pearse FRS [1988] Professor Jennifer Clack FRS [2009] Professor Fiona Powrie FRS [2011] Professor Nicola Clayton FRS [2010] Professor Susan Rees FRS [2002] Professor Suzanne Cory AC FRS [1992] Professor Daniela Rhodes FRS [2007] Dame Kay Davies DBE FMedSci FRS [2003] Professor Elizabeth Robertson FRS [2003] Professor Caroline Dean OBE FRS [2004] Dame Carol Robinson DBE FMedSci -
TRAPPING a STAR in a MAGNETIC DOUGHNUT the Physics of Magnetic Confinement Fusion
Spring 2016, Number 8 Department of Physics Newsletter TRAPPING A STAR IN A MAGNETIC DOUGHNUT The physics of magnetic confinement fusion RATTLING DARK MATTER THE CAGE: IN OUR GALAXY Making new superconductors Novel dynamics is bringing the Galaxy's and gravitational waves: using lasers dark matter into much sharper focus a personal reaction ALUMNI STORIES EVENTS PEOPLE Richard JL Senior and Elspeth Garman Remembering Dick Dalitz; Oxford Five minutes with Geoff Stanley; reflect on their experiences celebrates Nobel Prize; Physics Challenge Awards and Prizes Day and many more events www.physics.ox.ac.uk SCIENCE NEWS SCIENCE NEWS www.physics.ox.ac.uk/research www.physics.ox.ac.uk/research Prof James Binney FRS Right: Figure 2. The red arrows show the direction of the Galaxy’s gravitational field by our current DARK MATTER reckoning. The blue lines show the direction the field would have if the disc were massless. The mass © JOHN CAIRNS JOHN © IN OUR GALAXY of the disc tips the field direction In the Rudolf Peierls Centre for Theoretical Physics novel dynamics is towards the equatorial plane. A more massive disc would tip it bringing the Galaxy's dark matter into much sharper focus further. Far right: Figure 3. The orbits in In 1937 Fritz Zwicky pointed out that in clusters of clouds of hydrogen to large distances from the centre of the R plane of two stars that both galaxies like that shown in Fig. 1, galaxies move much NGC 3198. The data showed that gas clouds moved on z move past the Sun with a speed of faster than was consistent with estimates of the masses perfectly circular orbits at a speed that was essentially 72 km s−1. -
Curriculum Vitae - Dr
Curriculum Vitae - Dr. Niklas Boers CONTACT Potsdam Institute for Climate Impact Research Research Department IV - Complexity Science Future Lab “Artificial Intelligence in the Anthropocene” Telegraphenberg A31 14473 Potsdam email: [email protected] web: www.pik-potsdam.de/members/boers research gate: https://www.researchgate.net/profile/Niklas Boers ORCID: https://orcid.org/0000-0002-1239-9034 CURRENT POSITIONS Potsdam Institute for Climate Impact Research since 09/2019 Leader Future Lab “Artificial Intelligence in the Anthropocene” Free University Berlin since 09/2019 Junior research group leader at the Department of Mathematics and Computer Science University of Exeter since 09/2019 Senior Lecturer at the Global Systems Institute and Department of Mathematics FORMER ACADEMIC Potsdam Institut fur¨ Klimafolgenforschung 09/2018–08/2019 POSITIONS Humboldt fellow at the Department “Complexity Science” Imperial College London 09/2017–08/2018 Associate researcher at the Grantham Institute Advisors: Joanna Haigh and Brian Hoskins Ecole Normale Superieure´ de Paris 09/2015–08/2017 Humboldt fellow at the Geosciences Department and the Laboratoire de Met´ eorologie´ Dynamique Advisors: Michael Ghil and Denis-Didier Rousseau Potsdam Institut fur¨ Klimafolgenforschung 10/2011–08/2015 Guest researcher at the Department “Transdisciplinary Concepts and Methods” Advisor: Jurgen¨ Kurths Ludwig-Maximilians-Universitat¨ Munchen¨ 03/2011–09/2011 Associate researcher and lecture assistant at the Department of Mathematics Supervisors: Detlef Durr¨ and Peter Pickl HIGHER EDUCATION Humboldt-Universitat¨ zu Berlin PhD in Theoretical Physics 11/2011–04/2015 • Title: Complex Network Analysis of Extreme Rainfall in South America • Supervisors: Prof. Dr. Dr. h.c. mult. Jurgen¨ Kurths and Prof. Dr. Jose´ Marengo • Date of Defense: April 30th 2015 Ludwig-Maximilians-Universitat¨ Munchen¨ Diploma in Physics 09/2004–03/2011 • Diploma Thesis: Mean Field Limits for Classical Many Particle Systems • Supervisors: Prof. -
Virtual Birding: Extending Birdwatching to Review Acoustic Recordings
Virtual Birding: Extending Birdwatching to Review Acoustic Recordings Mark Cottman-Fields BInfTech (Queensland University of Technology) A thesis by monograph in fulfilment of the requirements for the degree of Doctor of Philosophy in Human-Computer Interaction 2017 Principal Supervisor Professor Paul Roe Associate Supervisor Professor Margot Brereton Ecoacoustics Research Group Computer-Human Interaction Discipline Electrical Engineering and Computer Science School Science and Engineering Faculty Queensland University of Technology Brisbane, Queensland, Australia To those who love the dawn chorus i Keywords Human-Computer Interaction; Acoustic Sensing; Birdwatching; Birding; Birdwatchers; Birders; Field Research; Exploratory Prototype; Citizen Science; Acoustic Analysis; Interviews; User-centred Design; Website Interface; Audio Recording Review; Ecoacoustics; Serious Leisure; Expert Community; Human Computation; Domain Expertise; Collaborative Extension; Environmental Sound; Terrestrial Sensing; Research in the Wild ii Abstract Observations made by birders have been integral to avian research and conservation efforts for decades. However, broader sources of data about avian activity are needed, to improve the information available for environmental management. Technology advances have seen acoustic monitoring emerge as a new way to study birds. The ever-increasing raw data from acoustic sensors requires processing, to extract information about bird activity. This is a difficult analysis problem, as there are just under 900 bird species in Australia and most have multiple distinct, yet variable, calls. There is an opportunity to extend birding activities to include collection and review of recorded audio. Currently, no acoustic analysis interfaces are available to enable collaboration between ecologists and experienced birders. Effective interfaces require an understanding of the culture and practices of birders, along with how birders can apply their experience to the review of recorded audio. -
The Labour Party and the Idea of Citizenship, C. 193 1-1951
The Labour Party and the Idea of Citizenship, c. 193 1-1951 ABIGAIL LOUISA BEACH University College London Thesis presented for the degree of PhD University of London June 1996 I. ABSTRACT This thesis examines the development and articulation of ideas of citizenship by the Labour Party and its sympathizers in academia and the professions. Setting this analysis within the context of key policy debates the study explores how ideas of citizenship shaped critiques of the relationships between central government and local government, voluntary groups and the individual. Present historiographical orthodoxy has skewed our understanding of Labour's attitude to society and the state, overemphasising the collectivist nature and centralising intentions of the Labour party, while underplaying other important ideological trends within the party. In particular, historical analyses which stress the party's commitment from the 1930s to achieving the transition to socialism through a strategy of planning, (of industrial development, production, investment, and so on), have generally concluded that the party based its programme on a centralised, expert-driven state, with control removed from the grasp of the ordinary people. The re-evaluation developed here questions this analysis and, fundamentally, seeks to loosen the almost overwhelming concentration on the mechanisms chosen by the Labour for the implementation of policy. It focuses instead on the discussion of ideas that lay behind these policies and points to the variety of opinions on the meaning and implications of social and economic planning that surfaced in the mid-twentieth century Labour party. In particular, it reveals considerable interest in the development of an active and participatory citizenship among socialist thinkers and politicians, themes which have hitherto largely been seen as missing elements in the ideas of the interwar and immediate postwar Labour party. -
The Rhodesian Crisis in British and International Politics, 1964
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by University of Birmingham Research Archive, E-theses Repository THE RHODESIAN CRISIS IN BRITISH AND INTERNATIONAL POLITICS, 1964-1965 by CARL PETER WATTS A thesis submitted to the University of Birmingham For the degree of DOCTOR OF PHILOSOPHY School of Historical Studies The University of Birmingham April 2006 University of Birmingham Research Archive e-theses repository This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. Abstract This thesis uses evidence from British and international archives to examine the events leading up to Rhodesia’s Unilateral Declaration of Independence (UDI) on 11 November 1965 from the perspectives of Britain, the Old Commonwealth (Canada, Australia, and New Zealand), and the United States. Two underlying themes run throughout the thesis. First, it argues that although the problem of Rhodesian independence was highly complex, a UDI was by no means inevitable. There were courses of action that were dismissed or remained under explored (especially in Britain, but also in the Old Commonwealth, and the United States), which could have been pursued further and may have prevented a UDI. -
IPG Spring 2020 Birding Titles - December 2019 Page 1
Birding Titles Spring 2020 {IPG} American Birding Association Field Guide to Birds of Hawaii Andre F. Raine, Helen Raine, Jack Jeffrey Summary This new book in the American Birding Association Field Guide Series includes complete coverage of all the major species, identification tips, and info on conservation status, habitat, and behaviors. Written by expert birders Helen & Andre F. Raine and filled with gorgeous color images by Jack Jeffrey, the American Birding Association Field Guide to Birds of Hawaii is the perfect companion for anyone wanting to learn more about the natural history and diversity of the state's birds, and when and where to see them. Contributor Bio Andre L. Raine, Ph.D . is the project coordinator of the Kaua’i Endangered Seabird Recovery Project in Kalaheo, Hawaii. Helen Raine is a writer and conservationist living in Kauai. Jack Jeffrey is a professional Scott & Nix, Inc. bird photographer, birding guide, and wildlife biologist. 9781935622710 Pub Date: 5/4/20 $24.95 USD Discount Code: LON Trade Paperback 272 Pages Carton Qty: 28 Nature / Birdwatching Guides NAT004000 Series: American Birding Association State Field 7.5 in H | 4.5 in W The Owl Calendar 2020 Jane Russ Summary An ideal gift for all owl lovers, this month-to-view wall calendar features 12 beautifully captured images of this ever-popular fixture of British wildlife. Supplied board-backed in a cello-bag with a hang tab. Each image is captioned by The Owl Book author Jane Russ, giving information and insight on their variety and characteristics. All Graffeg’s calendars are certified under the FSC system and are produced using materials Graffeg from sustainable sources. -
Crystallography News British Crystallographic Association
Crystallography News British Crystallographic Association Issue No. 99 December 2006 ISSN 1467-2790 BCA Spring Meeting 2007 - Canterbury p8-15 ECM Meeting p16-19 ACA - Honolulu p21-22 Awards of Medals p25-26 Meetings of Interest p27 Crystallography News December 2006 Contents From the President . 2 Council Members . 3 BCA From the Editor . 4 Administrative Office, Elaine Fulton, From Professor P Dolding Beedle. 5 Northern Networking Events Ltd. Puzzle Corner . 6 1 Tennant Avenue, College Milton South, East Kilbride, Glasgow G74 5NA Peter Main - Honorary Fellow . 6 Scotland, UK Tel: + 44 1355 244966 Fax: + 44 1355 249959 BCA 2007 Meeting . .8-13 e-mail: [email protected] BCA 2007 Meeting Timetable . 14-15 CRYSTALLOGRAPHY NEWS is is published quarterly (March, June, September and December) by the ECM . 16-19 British Crystallographic Association, and printed by William Anderson and Sons Ltd, Glasgow. Text should Groups . 20 preferably be sent electronically as MSword documents (any version - .doc, .rtf or .txt files). Diagrams and ACA . 21-22 figures are most welcome, but please send them separately from text as .jpg, .gif, .tif, or .bmp files. Items may include technical articles, news about Books . 23 people (e.g. awards, honours, retirements etc.), reports on past meetings of interest to His Worship Moreton Moore ................................... 23 crystallographers, notices of future meetings, historical reminiscences, letters to the editor, book, hardware or Obituary: Desmond Cunningham . 24 software reviews. Please ensure that items for inclusion in the March 2007 issue are sent to the Editor to arrive before 25th January 2007. Awards of Medals . 25-26 Bob Gould 33 Charterhall Road IUCr Wins Award .