United States Patent (10) Patent No.: US 9,511,107 B2 Rupasinghe Et Al
USO09511107B2 (12) United States Patent (10) Patent No.: US 9,511,107 B2 Rupasinghe et al. (45) Date of Patent: *Dec. 6, 2016 (54) PHENOLIC COMPOSITIONS DERIVED 4.551.348 A 1 1/1985 O’Mahony et al. FROM APPLE SKN AND USES THEREOF 4,626,434. A 12/1986 O’Mahony et al. 4,735,813 A 4, 1988 Spinoglio (71) Applicant:- - - Dalhousie University, Halifax (CA) 4,818,5494,743,455 A 4,5, 19881989 SteinerNichols et al. 4,879,122 A 11/1989 Seely, Jr. et al. (72) Inventors: Handunkutti Pathirannehalage 4,889,730 A 12/1989 Roberts et al. Vasantha Rupasinghe, Truro (CA); 4.948,609 A 8/1990 Nafisii-Movaghar George S. Robertson, Halifax (CA) 5,172,487. A 12/1992 Hansen et al. 5,188,861 A 2f1993 Mazin et al. (73) Assignee: DALHOUSIE UNIVERSITY, Halifax 5,523,106 A 6/1996 Gimmler et al. (CA) 5,534,280 A 7, 1996 Welch 5,676,042 A 10, 1997 Sakuma et al. (*) Notice: Subject to any disclaimer, the term of this St. A 1 h E. t tal patent is extended or adjusted under 35 5,840,354I k A 1 1/1998 BaumannaS a et al. U.S.C. 154(b) by 0 days. 5,939,117 A 8/1999 Chen et al. This patent is Subject to a terminal dis- 5,945,146 A 8, 1999 Twinam claimer. 6,440,410 Bl 8/2002 Yegorova 6,440,449 B1 8/2002 Hirschberg 6,440,467 B2 8, 2002 Mann (21) Appl. No.: 14/749,371 6,440,483 B1 8/2002 Ghaedian et al.
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