A Case Study of Imperforate Hymen and Its Management
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Genetic Syndromes and Genes Involved
ndrom Sy es tic & e G n e e n G e f Connell et al., J Genet Syndr Gene Ther 2013, 4:2 T o Journal of Genetic Syndromes h l e a r n a DOI: 10.4172/2157-7412.1000127 r p u y o J & Gene Therapy ISSN: 2157-7412 Review Article Open Access Genetic Syndromes and Genes Involved in the Development of the Female Reproductive Tract: A Possible Role for Gene Therapy Connell MT1, Owen CM2 and Segars JH3* 1Department of Obstetrics and Gynecology, Truman Medical Center, Kansas City, Missouri 2Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 3Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA Abstract Müllerian and vaginal anomalies are congenital malformations of the female reproductive tract resulting from alterations in the normal developmental pathway of the uterus, cervix, fallopian tubes, and vagina. The most common of the Müllerian anomalies affect the uterus and may adversely impact reproductive outcomes highlighting the importance of gaining understanding of the genetic mechanisms that govern normal and abnormal development of the female reproductive tract. Modern molecular genetics with study of knock out animal models as well as several genetic syndromes featuring abnormalities of the female reproductive tract have identified candidate genes significant to this developmental pathway. Further emphasizing the importance of understanding female reproductive tract development, recent evidence has demonstrated expression of embryologically significant genes in the endometrium of adult mice and humans. This recent work suggests that these genes not only play a role in the proper structural development of the female reproductive tract but also may persist in adults to regulate proper function of the endometrium of the uterus. -
AMENORRHOEA Amenorrhoea Is the Absence of Menses in a Woman of Reproductive Age
AMENORRHOEA Amenorrhoea is the absence of menses in a woman of reproductive age. It can be primary or secondary. Secondary amenorrhoea is absence of periods for at least 3 months if the patient has previously had regular periods, and 6 months if she has previously had oligomenorrhoea. In contrast, oligomenorrhoea describes infrequent periods, with bleeds less than every 6 weeks but at least one bleed in 6 months. Aetiology of amenorrhea in adolescents (from Golden and Carlson) Oestrogen- Oestrogen- Type deficient replete Hypothalamic Eating disorders Immaturity of the HPO axis Exercise-induced amenorrhea Medication-induced amenorrhea Chronic illness Stress-induced amenorrhea Kallmann syndrome Pituitary Hyperprolactinemia Prolactinoma Craniopharyngioma Isolated gonadotropin deficiency Thyroid Hypothyroidism Hyperthyroidism Adrenal Congenital adrenal hyperplasia Cushing syndrome Ovarian Polycystic ovary syndrome Gonadal dysgenesis (Turner syndrome) Premature ovarian failure Ovarian tumour Chemotherapy, irradiation Uterine Pregnancy Androgen insensitivity Uterine adhesions (Asherman syndrome) Mullerian agenesis Cervical agenesis Vaginal Imperforate hymen Transverse vaginal septum Vaginal agenesis The recommendations for those who should be evaluated have recently been changed to those shown below. (adapted from Diaz et al) Indications for evaluation of an adolescent with primary amenorrhea 1. An adolescent who has not had menarche by age 15-16 years 2. An adolescent who has not had menarche and more than three years have elapsed since thelarche 3. An adolescent who has not had a menarche by age 13-14 years and no secondary sexual development 4. An adolescent who has not had menarche by age 14 years and: (i) there is a suspicion of an eating disorder or excessive exercise, or (ii) there are signs of hirsutism, or (iii) there is suspicion of genital outflow obstruction Pregnancy must always be excluded. -
Clinical, Pathologic and Pharmacologic Correlations 2004
HUMAN REPRODUCTION: CLINICAL, PATHOLOGIC AND PHARMACOLOGIC CORRELATIONS 2004 Course Co-Director Kirtly Parker Jones, M.D. Professor Vice Chair for Educational Affairs Department of Obstetrics and Gynecology Course Co-Director C. Matthew Peterson, M.D. Professor and Chief Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology 1 Welcome to the course on Human Reproduction. This syllabus has been recently revised to incorporate the most recent information available and to insure success on national qualifying examinations. This course is designed to be used in conjunction with our website which has interactive materials, visual displays and practice tests to assist your endeavors to master the material. Group discussions are provided to allow in-depth coverage. We encourage you to attend these sessions. For those of you who are web learners, please visit our web site that has case studies, clinical/pathological correlations, and test questions. http://medstat.med.utah.edu/kw/human_reprod 2 TABLE OF CONTENTS Page Lectures/Examination................................................................................................................................... 4 Schedule........................................................................................................................................................ 5 Faculty .......................................................................................................................................................... 8 Groups ......................................................................................................................................................... -
Vaginal Agenesis: a Case Report*
Vaginal agenesis: A case report* By Reyalu T. Tan, MD; Sigrid A. Barinaga, MD, FPOGS; and Marie Janice S. Alcantara, MD, FPOGS Department of Obstetrics and Gynecology, Southern Philippine Medical Center ABSTRACT Congenital anomalies of the vagina are rare congenital anomalies. Women born with this anomaly present with collection of blood in the uterine cavity or hematometra and pelvic pain. Presented is a case of a 12-year old girl with hypogastric pain and primary amenorrhea complicated by vaginal agenesis. She was managed conservatively by creating a neovagina with the use of bipudendal flap or Modified Singapore flap. Management can be non-surgical or surgical but the management of congenital vaginal agenesis remains controversial. The decision to do a conservative surgical procedure or a hysterectomy depends on the clinical profile of the patient, the expertise of the surgeons, the extent of the anomaly, and its association to other congenital anomalies. Keywords: Vaginal Agenesis, Hematometra, Primary Amenorrhea, Modified Singapore flap INTRODUCTION congenital anomaly. The patient is an Elementary student, non-smoker, non-alcoholic beverage drinker, 2nd child of a evelopmental anomalies in mullerian ducts and G5P5 mother. urogenital sinus represent some of the most Two months prior to admission, the patient had Dinteresting disorders in Obstetrics and Gynecology. sudden onset of severe abdominal pain. Admitted at Normal development of the female reproductive system a local hospital and managed as a case of Ovarian New leads to differentiation of the reproductive structures. Growth with complication. At laparotomy, the patient Vaginal agenesis is the congenital absence of vagina was noted with hemoperitoneum (100 milliliter) with where there is failure of formation of the sinovaginal bulb the left fallopian tube enlarged to 5 x 9 centimeter with a which leads to outflow tract obstruction and infertility. -
Quinacrine Sterilization Induce Cryptomenorrhoea: a Rare Complication
JMSCR Volume||2||Issue||4||Pages 726-729||April 2014 2014 www.jmscr.igmpublication.org Impact Factcor-1.1147 ISSN (e)-2347-176x Quinacrine Sterilization Induce Cryptomenorrhoea: A Rare Complication Authors Brig Kumar Praveen MD (Gynae) *, Gp Capt JC Sharma MD (Gynae)1, Dr Rupa Talukdar , MD (Gynae )2 *Consultant (Obs & Gynae) Base Hospital Lucknow 1Associate prof ( Obs & Gyn) Army college of medical sciences Delhi Cantt. 2 Senior Gynaecologist , cantonment general hospital, Delhi Cantt. Email: [email protected] Abstract- Quinacrine was used as a non-surgical technique for permanent sterilization was been under study several years back . It was used and propagated by several resource poor countries to control population . It was relatively inexpensive and had mass acceptability due to similarity in procedure of IUCD insertion.. The side effects of this sterilization process have been reported to be low as compared to surgical methods. Menstrual abnormalities in the form of menorrhagia and ammenorrhoea have been reported but cryptomenorrhea was very uncommon complication. Here we present a case of quinacrin induced crypyomenorrhoea in a young women. Keywords: quinacrine, cryptomenorrhoea, trans cervical sterilization, heamatometra. INTRODUCTION population. It was relatively inexpensive and had Quinacrine was used as a non-surgical technique mass acceptability due to similarity in procedure for permanent sterilization was been under study of IUCD insertion.. The side effects of this several years back . It was used and propagated sterilization process have been reported to be low by several resource poor countries to control as compared to surgical methods. Menstrual Brig Kumar Praveen et al JMSCR Volume 2 Issue 4 April 2014 Page 726 JMSCR Volume||2||Issue||4||Pages 726-729||April 2014 2014 abnormalities in the form of menorrhagia and About100 ml of collected altered blood was ammenorrhoea have been reported but drained and sent for culture and sensitivity.(Fig 1). -
Management of Reproductive Tract Anomalies
The Journal of Obstetrics and Gynecology of India (May–June 2017) 67(3):162–167 DOI 10.1007/s13224-017-1001-8 INVITED MINI REVIEW Management of Reproductive Tract Anomalies 1 1 Garima Kachhawa • Alka Kriplani Received: 29 March 2017 / Accepted: 21 April 2017 / Published online: 2 May 2017 Ó Federation of Obstetric & Gynecological Societies of India 2017 About the Author Dr. Garima Kachhawa is a consultant Obstetrician and Gynaecologist in Delhi since over 15 years; at present, she is working as faculty at the premiere institute of India, prestigious All India Institute of Medical Sciences, New Delhi. She has several publications in various national and international journals to her credit. She has been awarded various national awards, including Dr. Siuli Rudra Sinha Prize by FOGSI and AV Gandhi award for best research in endocrinology. Her field of interest is endoscopy and reproductive and adolescent endocrinology. She has served as the Joint Secretary of FOGSI in 2016–2017. Abstract Reproductive tract malformations are rare in problems depend on the anatomic distortions, which may general population but are commonly encountered in range from congenital absence of the vagina to complex women with infertility and recurrent pregnancy loss. defects in the lateral and vertical fusion of the Mu¨llerian Obstructive anomalies present around menarche causing duct system. Identification of symptoms and timely diag- extreme pain and adversely affecting the life of the young nosis are an important key to the management of these women. The clinical signs, symptoms and reproductive defects. Although MRI being gold standard in delineating uterine anatomy, recent advances in imaging technology, specifically 3-dimensional ultrasound, achieve accurate Dr. -
Gynecological Problems in Newborns and Infants
Journal of Clinical Medicine Review Gynecological Problems in Newborns and Infants Katarzyna Wróblewska-Seniuk 1,* , Grazyna˙ Jarz ˛abek-Bielecka 2 and Witold K˛edzia 2 1 Department of Newborns’ Infectious Diseases, Chair of Neonatology, Poznan University of Medical Sciences, 60-535 Poznan, Poland 2 Department of Perinatology and Gynecology, Division of Developmental Gynecology and Sexology, Poznan University of Medical Sciences, 60-535 Poznan, Poland; [email protected] (G.J.-B.); [email protected] (W.K.) * Correspondence: [email protected]; Tel.: +48-60-739-3463 Abstract: Pediatric-adolescent or developmental gynecology has been separated from general gyne- cology because of the unique issues that affect the development and anatomy of growing girls and young women. It deals with patients from the neonatal period until maturity. There are not many gynecological problems that can be diagnosed in newborns; however, some are typical of the neonatal period. This paper aims to discuss the most frequent gynecological issues in the neonatal period. Keywords: newborn; developmental gynecology; pediatric gynecology; ovarian cysts; atypical- appearing genitals; hydrocolpos 1. Introduction Gynecology (from the Greek word ‘gyne’ = woman) is the area of medicine that specializes in the diagnosis and treatment of diseases affecting female reproductive or- Citation: Wróblewska-Seniuk, K.; gans (“woman’s diseases”). In a broader sense, this medical specialty covers the entire Jarz ˛abek-Bielecka,G.; K˛edzia,W. woman’s health, including preventive actions, and represents the specificity of anatomical Gynecological Problems in Newborns and physiological distinctness of sex. Pediatric-adolescent gynecology or developmental and Infants. J. Clin. Med. 2021, 10, gynecology is separated from general gynecology because of the unique issues that affect 1071. -
FOGSI Focus Endometriosis 2018
NOT FOR RESALE Join us on f facebook.com/JaypeeMedicalPublishers FOGSI FOCUS Endometriosis FOGSI FOCUS Endometriosis Editor-in-Chief Jaideep Malhotra MBBS MD FRCOG FRCPI FICS (Obs & Gyne) (FICMCH FIAJAGO FMAS FICOG MASRM FICMU FIUMB) Professor Dubrovnik International University Dubrovnik, Croatia Managing Director ART-Rainbow IVF Agra, Uttar Pradesh, India President FOGSI–2018 Co-editors Neharika Malhotra Bora MBBS MD (Obs & Gyne, Gold Medalist), FMAS, Fellowship in USG & Reproductive Medicine ICOG, DRM (Germany) Infertility Consultant Director, Rainbow IVF Agra, Uttar Pradesh, India Richa Saxena MBBS MD ( Obs & Gyne) PG Diploma in Clinical Research Obstetrician and Gynaecologist New Delhi, India The Health Sciences Publisher New Delhi | London | Panama Jaypee Brothers Medical Publishers (P) Ltd Headquarters Jaypee Brothers Medical Publishers (P) Ltd 4838/24, Ansari Road, Daryaganj New Delhi 110 002, India Phone: +91-11-43574357 Fax: +91-11-43574314 Email: [email protected] Overseas Offi ces J.P. Medical Ltd Jaypee-Highlights Medical Publishers Inc 83 Victoria Street, London City of Knowledge, Bld. 237, Clayton SW1H 0HW (UK) Panama City, Panama Phone: +44 20 3170 8910 Phone: +1 507-301-0496 Fax: +44 (0)20 3008 6180 Fax: +1 507-301-0499 Email: [email protected] Email: [email protected] Jaypee Brothers Medical Publishers (P) Ltd Jaypee Brothers Medical Publishers (P) Ltd 17/1-B Babar Road, Block-B, Shaymali Bhotahity, Kathmandu Mohammadpur, Dhaka-1207 Nepal Bangladesh Phone: +977-9741283608 Mobile: +08801912003485 Email: [email protected] Email: [email protected] Website: www.jaypeebrothers.com Website: www.jaypeedigital.com © 2018, Federation of Obstetric and Gynaecological Societies of India (FOGSI) 2018 The views and opinions expressed in this book are solely those of the original contributor(s)/author(s) and do not necessarily represent those of editor(s) of the book. -
Isolated Twisted Hematosalphinx Misleading with Ovarian Cyst Torsion
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Khairnar V et al. Int J Reprod Contracept Obstet Gynecol. 2019 Mar;8(3):1219-1222 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20190911 Case Report Isolated twisted hematosalphinx misleading with ovarian cyst torsion Vaibhav Khairnar*, Shalini Mahana Valecha, Pandeeswari Department of Obstetrics and Gynecology, ESI-PGIMSR, Mumbai, Maharashtra, India Received: 05 December 2018 Accepted: 05 February 2019 *Correspondence: Dr. Vaibhav Khairnar, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Normal or chronically inflamed fallopian tube can undergo torsion and present as acute abdomen, simulating clinically as ectopic gestation. Torsion of the fallopian tube is less frequent but significant cause of lower abdominal pain in reproductive age women that is difficult to recognize preoperatively. Authors present a rare case of hematosalpinx with torsion at its pedicle with hemoperitonium who presented as 28 years old female with acute abdomen that was successfully treated. In cases presenting with hemoperitoneum diagnosis of ruptured ectopic pregnancy should be made unless proved otherwise during reproductive age. Rarely ruptured ovarian cyst may also be a cause. Unfortunately, hematosalpinx sometimes can undergo torsion due to circulatory imbalance and can present as hemoperitoneum and circulatory collapse due to rupture. There have been no specific symptoms, clinical findings, imaging or laboratory characteristics identified for this condition. -
The Clinical Role of LASER for Vulvar and Vaginal Treatments in Gynecology and Female Urology: an ICS/ISSVD Best Practice Consensus Document
Received: 30 November 2018 | Accepted: 3 January 2019 DOI: 10.1002/nau.23931 SOUNDING BOARD The clinical role of LASER for vulvar and vaginal treatments in gynecology and female urology: An ICS/ISSVD best practice consensus document Mario Preti MD1 | Pedro Vieira-Baptista MD2,3 | Giuseppe Alessandro Digesu PhD4 | Carol Emi Bretschneider MD5 | Margot Damaser PhD5,6,7 | Oktay Demirkesen MD8 | Debra S. Heller MD9 | Naside Mangir MD10,11 | Claudia Marchitelli MD12 | Sherif Mourad MD13 | Micheline Moyal-Barracco MD14 | Sol Peremateu MD12 | Visha Tailor MD4 | TufanTarcanMD15 | EliseJ.B.DeMD16 | Colleen K. Stockdale MD, MS17 1 Department of Obstetrics and Gynecology, University of Torino, Torino, Italy 2 Hospital Lusíadas Porto, Porto, Portugal 3 Lower Genital Tract Unit, Centro Hospitalar de São João, Porto, Portugal 4 Department of Urogynaecology, Imperial College Healthcare, London, UK 5 Center for Urogynecology and Pelvic Reconstructive Surgery, Obstetrics, Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio 6 Glickman Urological and Kidney Institute and Department of Biomedical Engineering Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 7 Advanced Platform Technology Center, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio 8 Faculty of Medicine, Department of Urology, Istanbul University Cerrahpaşa, Istanbul, Turkey 9 Department of Pathology and Laboratory Medicine, Rutgers-New Jersey Medical School, Newark, New Jersey 10 Kroto Research Institute, Department of Material Science and Engineering, -
Mayer-Rokitansky-Litister-Hauser Syndrome (Mtillerian Duct Agenesis): Report of Two Cases
Mayer-Rokitansky-litister-Hauser syndrome (mtillerian duct agenesis): Report of two cases ROGER GUTHRIE, D.O. JOHN BUGGELN, D.O. RALPH MARTIN, D.O. Grand Rapids, Michigan to be inadequate and should be descriptionally Mdllerian duct agenesis typically changed to miillerian duct agenesis. results in normal ovaries, fallopian Two cases are reported to illustrate the diagnos- tubes meeting in the midline and tic approach. fusing, absence of uterus and vagina, with the presence of normal external Case 1 genitalia, and secondary sexual A 19-year-old black woman was admitted June 26, 1978, characteristics. The presenting chief with the complaint of cyclic headaches, dizziness, irrita- complaint is primary amenorrhea or bility, abdominal cramping, and backache every month failed intercourse. The first of the two without menses. The past medical history was noncon- cases reported is the classic syndrome. tributory. The surgical history included ventral hernia repair in infancy and repair of rectal prolapse at age 2 The second case varied in that the years. The family history revealed that the mother had right fimbriated fallopian tube ended sickle cell trait, hypertension, and diabetes controlled by in a blind stub 1 cm. in size and the left diet and oral hypoglycemic agents. The patient had five side had no fallopian tube but had a brothers and five sisters, all normal for their ages. The round ligament ending at the uterine patient admitted to normal secondary sexual develop- remnant stub. Diagnostic workup and ment without menarche. treatment can only be initiated by a Physical examination revealed the normal female sec- complete history and physical ondary sex characteristics. -
Imperforate Hymen Presenting with Massive Hematometra and Hematocolpos
logy & Ob o st ec e tr n i y c s G Okafor et al., Gynecol Obstet (Sunnyvale) 2015, 5:10 Gynecology & Obstetrics DOI: 10.4172/2161-0932.1000328 ISSN: 2161-0932 Case Report Open Access Imperforate Hymen Presenting with Massive Hematometra and Hematocolpos: A Case Report Okafor II*, Odugu BU, Ugwu IA, Oko DS, Enyinna PK and Onyekpa IJ Department of Obstetrics and Gynecology, Enugu State University Teaching Hospital, Enugu, Nigeria Abstract Background: Imperforate hymen is the commonest congenital anomaly that causes closure of the vagina. Ideally, diagnosis should be made early during fetal and neonatal examinations to prevent symptomatic presentations of its complications at puberty. Case report: We report a case of a 15-year-old girl who presented with delayed menarche, eight-month history of cyclic abdominal pain, and a three-week history of lower abdominal swelling. A doctor prescribed anthelmintic and analgesic drugs to her a month ago before she was verbally referred to ESUT Teaching Hospital, Enugu. The development of her secondary sexual characteristics was normal for her age. A 20 cm-sized suprapubic mass, and a bulging pinkish imperforate hymen were found on examination. Her transabdominal ultrasound revealed massive hematometra and hematocolpos. She had virginity-preserving hymenotomy and evacuation of about 1000 mls of accumulated coffee-colored menstrual blood. Conclusion: Clinicians should have high index of suspicion of imperforate hymen when assessing cases of delayed menarche with cyclic lower abdominal pain to prevent the consequences of its delayed treatment like massive hematometra and hematocolpos. Keywords: Imperforate hymen; Hematometra; Hematocolpos; of an imperforate hymen who presented late with delayed menarche, Hymenotomy; Enugu; Nigeria massive hematocolpos and hematometra.