Supplementary Table S1. Pyrosequencing Primers Used to Quantify the Methylation Status of Selected CG Sites

Supplementary Table S1. Pyrosequencing primers used to quantify the methylation status of selected CG sites.

CpG Probe ID Primer sequence Target Region coordinate Fwd: AGGAGGAGGGAATGTAAAATAGA chr3:148,415,620- AGTR1 149898314 Rev: ACTACCTAAAATCCTAACTATCAAAC 148,415,697 Seq: AGGGAATGTAAAATAGAGT

Fwd: AGGGAATTTTGGATTAGTAATTTGA chr6:94,129,308- EPHA7 94185987 Rev: CTTACTCCACACTCCAATAATATCA 94,129,484 Seq: GGAATTTTGGATTAGTAATTTGAT

Fwd: TTGTTAGAGGAGGGTGGAGAGG chr4:20,255,253- SLIT2 19864444 Rev: ACAAAAACAACATCTACCAACCA 20,255,449 Seq: TTTGGTATTTTGGGTTG

Fwd: AGGGGATGTTTTGTTTTTATTAGAG chr6:133,562,774- EYA4 133603412 Rev: TTCCCRAAAAATTTAAAAATTCTCTCAACT 133,562,943 Seq: GTTTTGTTTTTATTAGAGGTATAG

Fwd:GGAATTTTTAGGGAAGTTTTAGGTTAAAGA chr7:116,963,543- WNT2 116750796 Rev: TACAAATACTAACTCTTCATCCCAACTTCA 116,963,716 Seq: GGAAGTTTTAGGTTAAAGAGTA

Fwd: AGTTGAGTTAGGGGGTTTAGG chr17:75,369,482- SEPT9 Rev: AACAACCAACCCAACACC 75369562 75,369,637 Seq: GTTAGTTTTGTATTGTAGGAG

Fwd: AGTTTTAGGTTTYGGAGTAGGAAGGTT chr10:17,271,103- Rev: AAAATCCCCTCCCACTACCAT 17271192 VIM 17,271,233 Seq: GTTTTTAGTTYGGTTTTTATTGG Supplementary Table S2. Selected candidates: probes selected as candidates for colorectal cancer diagnostic markers based on microarray data.

Normal Tumor tissue tissue Probe Name Gene cg CpG t-test Chromosome Annotation Product Mean Mean Symbol number coordinate p-value (Standard (Standard deviation) deviation) Homo sapiens angiotensin angiotensin II II receptor, type 1 receptor, AGTR1_P41_F AGTR1 cg22498996 3 149898314 0.063 (0.003) 0.481 (0.033) 2.48E-21 (AGTR1), transcript type 1 variant 1, mRNA. Homo sapiens EPH ephrin receptor EPHA7_E6_F EPHA7 cg20253378 6 94185987 receptor A7 (EPHA7), EphA7 0.057 (0.002) 0.303 (0.028) 1.27E-13 mRNA. Homo sapiens wingless- wingless-type MMTV type MMTV integration integration site family WNT2_P217_F WNT2 cg02655774 7 116750796 0.070 (0.003) 0.495 (0.037) 1.40E-19 site family member 2 member 2 precursor (WNT2), mRNA. Homo sapiens eyes eyes absent 4 absent homolog 4 isoform a EYA4_E277_F EYA4 cg23916819 6 133604483 (Drosophila) (EYA4), 0.185 (0.011) 0.839 (0.02) 5.16E-41 transcript variant 1, mRNA. slit homolog 2 Homo sapiens slit homolog 2 SLIT2_E111_R SLIT2 cg26860620 4 19864444 0.113 (0.007) 0.653 (0.025) 2.61E-35 (Drosophila) (SLIT2), mRNA.

Supplementary Table S3. Differential methylation results in microarray data: loci found to be highly hypermethylated in tumor (mean difference greater than 0.20).

Standard Standard Mean Mean CpG deviation deviation t-test Probe Name CG number Chromosome Gene in Normal in Tumor Coordinate in Normal in Tumor p-value tissue tissue tissue tissue EYA4_E277_F cg23916819 6 133604483 EYA4 0.185 0.011 0.839 0.024 5.16E-41 SLIT2_E111_R cg26860620 4 19864444 SLIT2 0.113 0.007 0.653 0.025 2.61E-35 HS3ST2_E145_R cg22228897 16 22733506 HS3ST2 0.188 0.008 0.712 0.023 1.04E-34 NPY_E31_R cg25884711 7 24290365 NPY 0.130 0.008 0.664 0.025 1.06E-34 TMEFF2_P152_R cg10348923 2 192768041 TMEFF2 0.139 0.006 0.628 0.024 1.73E-34 NPY_P295_F cg20666532 7 24290039 NPY 0.321 0.016 0.843 0.020 1.17E-33 SLIT2_P208_F cg13875122 4 19864125 SLIT2 0.143 0.008 0.642 0.025 7.44E-33 SFRP1_P157_F cg15881237 8 41286294 SFRP1 0.129 0.009 0.704 0.030 8.24E-33 SFRP1_E398_R cg27086426 8 41285739 SFRP1 0.111 0.007 0.633 0.027 1.28E-32 TFPI2_P152_R cg12005526 7 93358153 TFPI2 0.126 0.007 0.653 0.026 1.97E-32 GABRB3_P92_F cg16084228 15 24570112 GABRB3 0.346 0.012 0.716 0.020 1.04E-30 TFPI2_P9_F cg16934178 7 93358010 TFPI2 0.106 0.009 0.629 0.028 1.27E-30 TWIST1_E117_R cg03005254 7 19123703 TWIST1 0.079 0.003 0.680 0.034 3.28E-30 NGFB_P13_F cg11660906 1 115682393 NGFB 0.135 0.006 0.626 0.028 6.55E-30 TWIST1_P355_R cg01202666 7 19124175 TWIST1 0.176 0.007 0.576 0.023 2.02E-28 EYA4_P794_F cg24842760 6 133603412 EYA4 0.163 0.007 0.636 0.028 6.33E-28 DBC1_E204_F cg06602847 9 121171318 DBC1 0.211 0.008 0.639 0.024 1.23E-27 TWIST1_P44_R cg12926104 7 19123864 TWIST1 0.133 0.006 0.631 0.030 8.17E-27 RASGRF1_E16_F cg16752670 15 77169879 RASGRF1 0.077 0.004 0.513 0.028 1.35E-26 TMEFF2_E94_R cg10026428 2 192767795 TMEFF2 0.051 0.002 0.574 0.034 2.01E-26 THY1_P149_R cg18809507 11 118799239 THY1 0.175 0.009 0.572 0.025 2.21E-26 NTSR1_P318_F cg03567830 20 60810316 NTSR1 0.179 0.008 0.668 0.031 3.83E-26 FLT4_P180_R cg20020551 5 180009352 FLT4 0.057 0.002 0.559 0.033 5.30E-26 SOX17_P287_R cg19346665 8 55532761 SOX17 0.317 0.016 0.704 0.023 7.89E-26 GSTM2_E153_F cg07246306 1 110012367 GSTM2 0.236 0.018 0.716 0.028 1.36E-25 FLI1_E29_F cg20448922 11 128069228 FLI1 0.152 0.012 0.623 0.031 1.51E-25 HS3ST2_P171_F cg03823653 16 22733190 HS3ST2 0.107 0.007 0.517 0.029 3.67E-25 KDR_P445_R cg04695981 4 55686964 KDR 0.205 0.010 0.577 0.024 3.75E-25 NPY_P91_F cg20961293 7 24290243 NPY 0.042 0.001 0.377 0.023 4.50E-25 TPEF_seq_44_S88_R cg09698887 2 192767395 TMEFF2 0.173 0.008 0.581 0.027 5.58E-25 IGFBP3_P423_R cg12826145 7 45927819 IGFBP3 0.128 0.007 0.551 0.029 6.96E-25 SOX17_P303_F cg09626193 8 55532745 SOX17 0.268 0.015 0.604 0.026 1.77E-24 ALK_E183_R cg02931220 2 29997753 ALK 0.084 0.003 0.457 0.027 2.07E-24 ESR1_P151_R cg05171584 6 152170228 ESR1 0.436 0.017 0.801 0.019 2.23E-24 DLK1_E227_R cg20175079 14 100263209 DLK1 0.309 0.015 0.722 0.024 2.29E-24 NTRK3_P636_R cg25116345 15 86601301 NTRK3 0.147 0.008 0.515 0.025 2.52E-24 NTRK3_P752_F cg09147530 15 86601417 NTRK3 0.093 0.004 0.491 0.028 4.23E-24 MYOD1_E156_F cg20325846 11 17697891 MYOD1 0.249 0.012 0.608 0.022 7.61E-24 TFPI2_E141_F cg23686014 7 93357860 TFPI2 0.086 0.004 0.381 0.021 1.52E-23 ADCYAP1_P398_F cg01521573 18 894989 ADCYAP1 0.249 0.012 0.635 0.024 2.49E-23 ESR1_E298_R cg17191385 6 152170677 ESR1 0.114 0.006 0.501 0.028 3.00E-23 HTR1B_E232_R cg26034501 6 78229607 HTR1B 0.313 0.013 0.685 0.023 3.73E-23 GAS7_E148_F cg20649212 17 10042445 GAS7 0.053 0.003 0.505 0.033 4.30E-23 NGFB_E353_F cg02459758 1 115682027 NGFB 0.069 0.003 0.542 0.035 6.19E-23 CD40_P372_R cg26940394 20 44179941 CD40 0.114 0.007 0.547 0.033 7.36E-23 ADAMTS12_E52_R cg13887940 5 33927829 ADAMTS12 0.168 0.007 0.504 0.024 7.65E-23 CDH13_P88_F cg08977371 16 81217991 CDH13 0.286 0.012 0.701 0.030 7.66E-23 FLT4_E206_F cg17414561 5 180008966 FLT4 0.076 0.004 0.303 0.018 8.45E-23 HOXA5_P1324_F cg05640017 7 27151136 HOXA5 0.092 0.006 0.493 0.030 1.85E-22 SCGB3A1_E55_R cg19421379 5 179951038 SCGB3A1 0.153 0.009 0.576 0.031 2.30E-22 TGFB2_E226_R cg20490551 1 216586717 TGFB2 0.319 0.015 0.745 0.029 1.49E-21 AGTR1_P41_F cg22498996 3 149898314 AGTR1 0.063 0.003 0.481 0.033 2.48E-21 ER_seq_a1_S60_F cg16246567 6 152170860 ESR1 0.091 0.005 0.458 0.029 2.87E-21 HOXA5_E187_F cg12041264 7 27149625 HOXA5 0.539 0.023 0.881 0.020 3.25E-21 KDR_E79_F cg10740902 4 55686440 KDR 0.159 0.011 0.478 0.026 4.03E-21 DAB2IP_E18_R cg13907787 9 123501488 DAB2IP 0.053 0.006 0.487 0.034 4.25E-21 GSTM2_P453_R cg11063364 1 110011761 GSTM2 0.426 0.017 0.730 0.018 4.98E-21 CSPG2_E38_F cg21708808 5 82803377 CSPG2 0.172 0.008 0.577 0.030 5.54E-21 MYOD1_P50_F cg27060180 11 17697685 MYOD1 0.255 0.011 0.601 0.025 5.99E-21 FGF5_P238_R cg23520103 4 81406528 FGF5 0.080 0.005 0.515 0.036 1.08E-20 TBX1_P885_R cg03402455 22 18123341 TBX1 0.124 0.005 0.517 0.030 1.86E-20 PENK_P447_R cg07433146 8 57521590 PENK 0.391 0.019 0.712 0.023 3.21E-20 ALK_P28_F cg14528334 2 29997964 ALK 0.054 0.002 0.417 0.030 5.45E-20 NTRK3_E131_F cg00865584 15 86600534 NTRK3 0.054 0.002 0.404 0.029 7.91E-20 MOS_E60_R cg09241196 8 57189035 MOS 0.494 0.020 0.831 0.019 1.04E-19 WNT2_P217_F cg02655774 7 116750796 WNT2 0.070 0.003 0.495 0.037 1.40E-19 NRG1_E74_F cg25833018 8 32525369 NRG1 0.063 0.002 0.323 0.022 1.70E-19 GABRB3_E42_F cg20421990 15 24569978 GABRB3 0.137 0.008 0.429 0.024 3.45E-19 WT1_E32_F cg20134916 11 32413631 WT1 0.104 0.005 0.532 0.037 3.70E-19 EYA4_P508_F cg19148393 6 133603698 EYA4 0.076 0.007 0.415 0.028 4.30E-19 FGF5_E16_F cg08153517 4 81406782 FGF5 0.045 0.001 0.415 0.032 5.13E-19 HS3ST2_P546_F cg23911889 16 22732815 HS3ST2 0.082 0.004 0.351 0.022 6.96E-19 FGF3_P171_R cg15119027 11 69343300 FGF3 0.165 0.007 0.528 0.031 1.61E-18 EPHA5_E158_R cg25798792 4 66217946 EPHA5 0.074 0.005 0.386 0.027 1.66E-18 IGF2AS_E4_F cg16130058 11 2118327 IGF2AS 0.048 0.002 0.316 0.024 1.94E-18 CDH13_E102_F cg15047333 16 81218181 CDH13 0.101 0.004 0.470 0.032 3.18E-18 TUSC3_P85_R cg17170317 8 15442016 TUSC3 0.185 0.012 0.496 0.025 3.60E-18 CCNA1_P216_F cg05780306 13 35904417 CCNA1 0.203 0.014 0.496 0.027 5.82E-18 NRG1_P558_R cg12863621 8 32524737 NRG1 0.070 0.003 0.387 0.029 6.03E-18 GSTM2_P109_R cg25855733 1 110012105 GSTM2 0.134 0.009 0.443 0.027 1.02E-17 BDNF_P259_R cg18882544 11 27700131 BDNF 0.362 0.012 0.673 0.026 1.48E-17 WT1_P853_F cg08219028 11 32414516 WT1 0.110 0.007 0.421 0.030 1.72E-17 CDH11_P354_R cg13126606 16 63713774 CDH11 0.207 0.008 0.543 0.030 3.07E-17 OPCML_E219_R cg19151121 11 132907394 OPCML 0.142 0.007 0.448 0.029 3.60E-17 ADCYAP1_P455_R cg01799816 18 894932 ADCYAP1 0.090 0.004 0.383 0.027 3.98E-17 FLT3_E326_R cg18969328 13 27572379 FLT3 0.131 0.008 0.539 0.038 5.03E-17 THY1_P20_R cg11980653 11 118799110 THY1 0.120 0.005 0.343 0.021 6.45E-17 NEFL_P209_R cg05876319 8 24870155 NEFL 0.432 0.016 0.739 0.025 7.43E-17 HIC-1_seq_48_S103_R cg20066299 17 1907679 HIC1 0.344 0.017 0.697 0.027 7.69E-17 DBC1_P351_R cg14445814 9 121171873 DBC1 0.152 0.008 0.451 0.028 1.32E-16 TUSC3_E29_R cg10249582 8 15442130 TUSC3 0.343 0.021 0.690 0.026 1.47E-16 MME_E29_F cg20228377 3 156280182 MME 0.096 0.006 0.521 0.042 1.50E-16 ALPL_P433_F cg23352747 1 21708023 ALPL 0.353 0.013 0.619 0.022 1.82E-16 CYP1B1_E83_R cg09991178 2 38156713 CYP1B1 0.093 0.004 0.461 0.036 3.39E-16 DCC_P471_R cg22055405 18 48120685 DCC 0.148 0.007 0.468 0.032 7.77E-16 CHFR_P501_F cg00470794 12 131974758 CHFR 0.067 0.003 0.433 0.037 1.14E-15 BDNF_E19_R cg17037622 11 27699853 BDNF 0.141 0.004 0.368 0.023 1.96E-15 HCK_P858_F cg04775393 20 30102860 HCK 0.383 0.016 0.689 0.029 3.20E-15 SOX1_P294_F cg23071766 13 111769620 SOX1 0.135 0.007 0.491 0.038 3.74E-15 MMP2_P303_R cg20640526 16 54070286 MMP2 0.185 0.010 0.457 0.026 3.88E-15 IRAK3_P13_F cg22778955 12 64869271 IRAK3 0.050 0.002 0.405 0.037 5.50E-15 GALR1_E52_F cg15343119 18 73090773 GALR1 0.051 0.002 0.330 0.029 5.58E-15 GUCY2D_E419_R cg13065528 17 7847132 GUCY2D 0.073 0.003 0.338 0.028 7.25E-15 FGF2_P229_F cg03941587 4 123967084 FGF2 0.394 0.014 0.657 0.024 8.47E-15 FGF3_E198_R cg12845334 11 69342931 FGF3 0.037 0.001 0.273 0.025 1.24E-14 MYH11_P22_F cg15581089 16 15858391 MYH11 0.107 0.012 0.451 0.037 1.57E-14 MMP2_E21_R cg16119420 16 54070610 MMP2 0.059 0.003 0.283 0.024 1.70E-14 EPHA5_P66_F cg02463418 4 66218170 EPHA5 0.621 0.016 0.823 0.013 1.90E-14 HPN_P374_R cg03537100 19 40222876 HPN 0.361 0.014 0.573 0.019 2.67E-14 IGF2AS_P203_F cg14188639 11 2118120 IGF2AS 0.556 0.018 0.805 0.020 4.33E-14 GAS7_P622_R cg10250043 17 10043215 GAS7 0.427 0.019 0.749 0.028 4.44E-14 CHGA_E52_F cg15962606 14 92459297 CHGA 0.289 0.015 0.541 0.028 5.99E-14 COL1A2_E299_F cg22877867 7 93862108 COL1A2 0.081 0.004 0.361 0.031 1.03E-13 IRAK3_E130_F cg06323619 12 64869414 IRAK3 0.050 0.002 0.327 0.032 1.20E-13 EPHA7_E6_F cg20253378 6 94185987 EPHA7 0.057 0.002 0.303 0.028 1.27E-13 CSPG2_P82_R cg02861411 5 82803257 CSPG2 0.101 0.004 0.409 0.035 1.42E-13 EPHA7_P205_R cg24188617 6 94186198 EPHA7 0.061 0.003 0.313 0.029 1.51E-13 CD40_E58_R cg20698532 20 44180371 CD40 0.127 0.010 0.358 0.027 1.53E-13 HOXA5_P479_F cg27409178 7 27150291 HOXA5 0.622 0.018 0.829 0.019 2.85E-13 TNFRSF10C_P7_F cg23831143 8 23016372 TNFRSF10C 0.104 0.004 0.342 0.027 2.86E-13 RBP1_P150_F cg11861701 3 140741330 RBP1 0.144 0.009 0.374 0.026 3.36E-13 NEFL_E23_R cg00987688 8 24869923 NEFL 0.524 0.031 0.760 0.023 3.56E-13 ALOX12_P223_R cg22819332 17 6839905 ALOX12 0.404 0.020 0.649 0.029 3.59E-13 TCF4_P317_F cg06256989 18 51406757 TCF4 0.295 0.014 0.584 0.031 3.84E-13 MEG3_E91_F cg27191825 14 100362306 MEG3 0.374 0.014 0.575 0.020 4.17E-13 ALOX12_E85_R cg05878700 17 6840213 ALOX12 0.450 0.019 0.703 0.028 5.02E-13 IRAK3_P185_F cg24003063 12 64869099 IRAK3 0.252 0.014 0.537 0.033 6.16E-13 PALM2- PALM2- AKAP2_P420_R cg12992456 9 111581990 AKAP2 0.255 0.015 0.539 0.030 8.23E-13 DCC_P177_F cg22444505 18 48120979 DCC 0.138 0.007 0.394 0.030 9.36E-13 EPO_E244_R cg13036038 7 100156603 EPO 0.092 0.007 0.314 0.027 1.14E-12 TIAM1_P117_F cg06524895 21 31853278 TIAM1 0.057 0.009 0.334 0.035 1.27E-12 PDE1B_P263_R cg06901488 12 53229408 PDE1B 0.035 0.001 0.268 0.028 1.35E-12 GLI3_P453_R cg23194824 7 42242165 GLI3 0.129 0.007 0.403 0.031 1.74E-12 FGFR1_P204_F cg20658205 8 38445497 FGFR1 0.072 0.003 0.273 0.024 2.68E-12 RBP1_E158_F cg21141873 3 140741022 RBP1 0.082 0.006 0.311 0.028 2.79E-12 CCNA1_E7_F cg27186533 13 35904640 CCNA1 0.667 0.022 0.885 0.016 4.71E-12 ASCL2_P609_R cg00868120 11 2249367 ASCL2 0.221 0.014 0.460 0.030 6.81E-12 PENK_E26_F cg25021837 8 57521117 PENK 0.663 0.018 0.868 0.017 7.30E-12 TIAM1_P188_R cg02217293 21 31853349 TIAM1 0.051 0.002 0.288 0.030 1.18E-11 ZNF264_E48_R cg08504049 19 62394729 ZNF264 0.116 0.007 0.359 0.030 1.48E-11 HTR1B_P222_F cg06824029 6 78230061 HTR1B 0.100 0.004 0.359 0.032 1.90E-11 SEZ6L_P249_F cg20207331 22 24895231 SEZ6L 0.049 0.003 0.258 0.027 1.99E-11 SMARCA3_P17_R cg01427078 3 150287024 SMARCA3 0.119 0.005 0.338 0.027 3.56E-11 TAL1_P594_F cg13537642 1 47468624 TAL1 0.311 0.012 0.534 0.027 1.19E-10 SMARCA3_E20_F cg27077285 3 150286987 SMARCA3 0.046 0.002 0.295 0.034 2.07E-10 SEZ6L_P299_F cg09131631 22 24895181 SEZ6L 0.056 0.002 0.273 0.030 3.93E-10 INHA_P1144_R cg01858402 2 220144054 INHA 0.047 0.002 0.271 0.032 4.83E-10

Supplementary Table S4. Loci consistently unmethylated in microarray normal samples: differential methylation results for loci for

33 loci found to be highly hypermethylated in tumor (mean difference greater than 0.20) and consistently unmethylated in most of the adjacent non neoplastic samples.

Standard Standard Mean Mean CpG deviation deviation t-test Probe Name CG number Chromosome Gene in Normal in Tumor Coordinate in Normal in Tumor p-value tissue tissue tissue tissue TWIST1_E117_R cg03005254 7 19123703 TWIST1 0.079 0.003 0.680 0.034 3.28E-30 TMEFF2_E94_R cg10026428 2 192767795 TMEFF2 0.051 0.002 0.574 0.034 2.01E-26 FLT4_P180_R cg20020551 5 180009352 FLT4 0.057 0.002 0.559 0.033 5.30E-26 NPY_P91_F cg20961293 7 24290243 NPY 0.042 0.001 0.377 0.023 4.50E-25 ALK_E183_R cg02931220 2 29997753 ALK 0.084 0.003 0.457 0.027 2.07E-24 GAS7_E148_F cg20649212 17 10042445 GAS7 0.053 0.003 0.505 0.033 4.30E-23 NGFB_E353_F cg02459758 1 115682027 NGFB 0.069 0.003 0.542 0.035 6.19E-23 AGTR1_P41_F cg22498996 3 149898314 AGTR1 0.063 0.003 0.481 0.033 2.48E-21 ALK_P28_F cg14528334 2 29997964 ALK 0.054 0.002 0.417 0.030 5.45E-20 NTRK3_E131_F cg00865584 15 86600534 NTRK3 0.054 0.002 0.404 0.029 7.91E-20 WNT2_P217_F cg02655774 7 116750796 WNT2 0.070 0.003 0.495 0.037 1.40E-19 NRG1_E74_F cg25833018 8 32525369 NRG1 0.063 0.002 0.323 0.022 1.70E-19 FGF5_E16_F cg08153517 4 81406782 FGF5 0.045 0.001 0.415 0.032 5.13E-19 HS3ST2_P546_F cg23911889 16 22732815 HS3ST2 0.082 0.004 0.351 0.022 6.96E-19 IGF2AS_E4_F cg16130058 11 2118327 IGF2AS 0.048 0.002 0.316 0.024 1.94E-18 CDH13_E102_F cg15047333 16 81218181 CDH13 0.101 0.004 0.470 0.032 3.18E-18 NRG1_P558_R cg12863621 8 32524737 NRG1 0.070 0.003 0.387 0.029 6.03E-18 CHFR_P501_F cg00470794 12 131974758 CHFR 0.067 0.003 0.433 0.037 1.14E-15 IRAK3_P13_F cg22778955 12 64869271 IRAK3 0.050 0.002 0.405 0.037 5.50E-15 GALR1_E52_F cg15343119 18 73090773 GALR1 0.051 0.002 0.330 0.029 5.58E-15 GUCY2D_E419_R cg13065528 17 7847132 GUCY2D 0.073 0.003 0.338 0.028 7.25E-15 FGF3_E198_R cg12845334 11 69342931 FGF3 0.037 0.001 0.273 0.025 1.24E-14 MMP2_E21_R cg16119420 16 54070610 MMP2 0.059 0.003 0.283 0.024 1.70E-14 IRAK3_E130_F cg06323619 12 64869414 IRAK3 0.050 0.002 0.327 0.032 1.20E-13 EPHA7_E6_F cg20253378 6 94185987 EPHA7 0.057 0.002 0.303 0.028 1.27E-13 EPHA7_P205_R cg24188617 6 94186198 EPHA7 0.061 0.003 0.313 0.029 1.51E-13 PDE1B_P263_R cg06901488 12 53229408 PDE1B 0.035 0.001 0.268 0.028 1.35E-12 FGFR1_P204_F cg20658205 8 38445497 FGFR1 0.072 0.003 0.273 0.024 2.68E-12 TIAM1_P188_R cg02217293 21 31853349 TIAM1 0.051 0.002 0.288 0.030 1.18E-11 SEZ6L_P249_F cg20207331 22 24895231 SEZ6L 0.049 0.003 0.258 0.027 1.99E-11 SMARCA3_E20_F cg27077285 3 150286987 SMARCA3 0.046 0.002 0.295 0.034 2.07E-10 SEZ6L_P299_F cg09131631 22 24895181 SEZ6L 0.056 0.002 0.273 0.030 3.93E-10 INHA_P1144_R cg01858402 2 220144054 INHA 0.047 0.002 0.271 0.032 4.83E-10