Rhode Island Chapter Abstracts

Total Page:16

File Type:pdf, Size:1020Kb

Rhode Island Chapter Abstracts Rhode Island Chapter Abstracts April 1, 2015 Abdin, Ahmad Last Name: Abdin First Author: Resident First Name: Ahmad Category: Clinical Vignette PG Year: PGY-1 or MS Year: ACP Number: 2888549 Medical School or Residency Program: Warren Alpert Medical School of Brown University Hospital Affiliation: Memorial Hospital of Rhode Island, Providence VA Medical Center Additional Authors: Ahmad Abdin, MD, Mohammed Salhab, MD, Amos Charles, MD, Mazen Al-Qadi, MD Abstract Title: Amiodarone-Induced Cerebellar Dysfunction Abstract Text: Introduction: Amiodarone is a class III antiarrhythmic agent that is widely used to treat ventricular and supraventricular tachycardias. Several side-effects of the drug have been recognized including thyroid dysfunction, photosensitivity, hepatotoxicity, parenchymal lung disease, corneal deposits, and peripheral neuropathy. Cerebellar dysfunction is rarely seen in patients receiving amiodarone. We are reporting a rare case of amiodarone-induced cerebellar dysfunction that resolved completely upon discontinuation of the drug. Case Presentation: A 73-year-old man with a past medical history significant for paroxysmal atrial fibrillation, coronary artery disease, diabetes and hypertension who presented with worsening lower extremity weakness and unsteady gait with recurrent falls for the last 6 months. Two days prior to admission, his symptoms got worse and caused him to seek medical attention. Two years ago he was started and maintained on amiodarone 200 mg daily for rhythm control. On physical examination, vital signs were normal. A wide-based unsteady gait was noted. He had dysmetria bilaterally on finger-to-nose and heel-to-shin testing. The rapid alternating movements of the hands were irregular. The remainder of the general and neurologic examinations were unremarkable. His laboratory data revealed mild chronic transaminitis, but otherwise normal. His electrocardiogram demonstrated normal sinus rhythm with no acute changes. His brain magnetic resonance imaging was negative for acute or chronic pathology. Reviewing his medications did not reveal any neurotoxicity as a side effect except for amidarone; hence, amiodarone was discontinued. Four days later, his ataxia significantly improved and he was discharged home. Six weeks later, all his neurological symptoms had resolved. Discussion: Amiodarone is a thyroxine-like agent that is derived from benzofuran and is commonly prescribed for arrhythmia control. It blocks the potassium channels, causing slow repolarization and prolonged action potential (refractory period). Amiodarone has sodium- and calcium-blocking activities in addition to some alpha- and beta-blocking effect. It has a very long elimination half-life of several (up to 6) months. Despite its efficacy, approximately 50% of patients receiving the drug suffer more than mild adverse events and 10-15% discontinue the drug due to intolerance. Amiodarone-induced neurotoxicity develops in 3-30% of patients and mainly involves the peripheral nervous system to cause sensorimotor neuropathy. Although amiodarone crosses the blood brain barrier, involvement of the central nervous system is rarely encountered and may include cerebellar ataxia. The pathogenesis of cerebellar injury remains unknown. Rapid resolution of cerebellar symptoms is common (within few days of discontinuation), and complete recovery is to be expected within few months. Cerebellar dysfunction is an uncommon manifestation of amiodarone-induced neurotoxicity. Elderly patients are at high risk of developing amiodarone-induced cerebellar dysfunction and should receive the lowest possible dose to control their arrhythmia. Adjei, Naomi Last Name: Adjei First Author: Medical Student First Name: Naomi Category: Research PG Year: or MS Year: MS-2 ACP Number: 2209413 Medical School or Residency Program: Warren Alpert Medical School of Brown University Hospital Affiliation: Additional Authors: Naomi Adjei, Dorothy Liu*, Kunal Sindhu*, Michael Yacovelli*, Vinay Rao, and Susanna Magee, MD (* th Abstract Title: Changing the face of sex education in Rhode Island Abstract Text: Introduction: Despite progress in recent years, the teenage pregnancy rate in the United States remains the highest in the industrialized world: in 2011, there were 31.3 births per 1000 women aged 15-19 nationwide. This often reported figure, however, masks vast regional disparities. For example, while the states of New England possess some of the lowest teenage pregnancy rates in the country, Rhode Island has historically lagged behind its neighbors. In fact, in the state’s most affected city, Central Falls, the teenage pregnancy rate is nearly three times higher than the national average. While the consequences of early and risky sexual activity can be devastating, a large proportion of sexually active teenagers are not informed of the risks of their behavior. Of the women aged 15-19 who gave birth nationwide in 2011, for example, nearly half were not using any form of birth control when they conceived; within this group, 31% did not believe that they could get pregnant at the time.1 These shocking figures justify the need for immediate intervention. Methods: Previous work has shown that early and comprehensive sexual health education is effective in promoting healthy sexual decision making among adolescents. With this in mind, five medical students from The Warren Alpert School of Medicine at Brown University founded Sex Ed by Brown Med with the express aims of improving adolescents’ knowledge of and influencing their attitudes towards sexual health. With assistance from the Rhode Island Department of Health and the Board of the Central Falls School District, 41 first- and second-year medical students volunteered to teach seven lessons to 168 8th grade students at a middle school in Central Falls in the fall of 2014. Results: To assess baseline knowledge and knowledge acquisition, the middle school students were administered a 17-question, mixed format assessment both before and after the lessons were delivered. Over the course of the semester, the students’ average assessment score rose from 68.3% to 78.1%, a difference that was statistically significant (p<0.001). In addition, the students also scored significantly better in both the sexual health and reproductive anatomy sections of the post-assessment (76.3% vs 66.7%, p<0.001 and 91.1% vs 80.1%, p<0.01). Conclusion: While the students enrolled in our course demonstrated statistically significant improvements in sexual health knowledge, we recognize that our mission to eradicate teenage pregnancy in Rhode Island is by no means accomplished. However, we have established a nascent educational infrastructure that we hope to build upon going forward. For the upcoming semester, we have expanded our program to include seventh grade students and will seek to broaden our impact in the years to come. Afari, Maxwell Last Name: Afari First Author: Resident First Name: Maxwell Category: Research PG Year: PGY-3 or MS Year: ACP Number: 1706139 Medical School or Residency Program: Alpert Medical School of Brown University Hospital Affiliation: Memorial Hospital of Rhode Island Additional Authors: Hammad Shafqat, Muhammad Shafi, Fady Marmoush, Taro Minami Abstract Title: Hypertriglyceridemia Induced Pancreatitis: A Decade of Experience In A Community- Based Teaching Hospital Abstract Text: Background: Hypertriglyceridemia is the third most common cause of acute pancreatitis. The current evidence on the management of hypertriglyceridemia induced pancreatitis (HIP) is mainly derived from case series suggesting an adjunctive role for insulin, heparin, and plasmapheresis in addition to the conventional therapies (statins and fibrates). We present a retrospective review of patients seen at the Memorial Hospital of Rhode Island from 2005 to 2015. Methods: Patients aged 18 years or greater, with clinical diagnosis of acute pancreatitis and serum triglyceride >1000mg/dL were included in this study. The following data were collected: patients’ demographics, clinical presentation, laboratory, treatment method, length of hospital stay, and complications. This study was given an exempt status by the local Institutional Review Board. Results: Out of the 549 admissions for acute pancreatitis, only 14 patients met our inclusion criteria. The mean age was 39± 8 years and there were more men (57%) than women (43%). More than two- thirds of the patients were admitted to the Intensive Care Unit. Majority of the patients were treated with insulin drip (n=8), and the rest by subcutaneous insulin (n=3) and insulin drip+ plasmapheresis (n=3). In the insulin drip group we noted a gradual decrease of the admission serum triglycerides by 50.6 ±16.0 % (at 24hours), 65.9±16.9% (at 48 hours) and 85.2± 7.1% at discharge. At the time of discharge, the triglyceride had decreased by 79.8% and 92.6 % in the subcutaneous insulin and insulin+plasmapheresis cohorts respectively. Patients treated with insulin+Plasmapheresis stayed longer in the hospital (20.7±3.1 days) compared to those on insulin drip (10.3±5.4 days) and subcutaneous insulin (5.7 ± 1.2 days). No mortality was recorded in this review. While there were no complications in subcutaneous insulin group, two- thirds of the Insulin+plasmapheresis group and half of the insulin drip cohort had complications such as small bowel obstruction, spontaneous bacterial peritonitis, and respiratory failure. Discussion: The mechanism of HIP is through the stimulation of pancreatic lipase in the presence of excess triglycerides.
Recommended publications
  • Dysmagnesemia in Covid-19 Cohort Patients: Prevalence and Associated Factors
    Magnesium Research 2020; 33 (4): 114-122 ORIGINAL ARTICLE Dysmagnesemia in Covid-19 cohort patients: prevalence and associated factors Didier Quilliot1, Olivier Bonsack1, Roland Jaussaud2, Andre´ Mazur3 1 Transversal Nutrition Unit and; 2 Internal Medicine and Clinical Immunology. Nancy University Hospital, University of Lorraine, France; 3 Universite´ Clermont Auvergne, INRAE, UNH, Unite´ de Nutrition Humaine, Clermont-Ferrand, France Correspondence <[email protected]> Abstract. Hypomagnesemia and hypermagnesemia could have serious implications and possibly lead to progress from a mild form to a severe outcome of Covid-19. Susceptibility of subjects with low magnesium status to develop and enhance this infection is possible. There is little data on the magnesium status of patients with Covid-19 with different degrees of severity. This study was conducted to evaluate prevalence of dysmagnesemia in a prospective Covid-19 cohort study according to the severity of the clinical manifestations and to identify factors associated. Serum magnesium was measured in 300 of 549 patients admitted to the hospital due to severe Covid-19. According to the WHO guidelines, patients were classified as moderate, severe, or critical. 48% patients had a magnesemia below 0.75 mmol/L (defined as magnesium deficiency) including 13% with a marked hypomagnesemia (<0.65 mmol/L). 9.6% had values equal to or higher than 0.95 mmol/L. Serum magnesium concentrations were significantly lower in female than in male (0.73 Æ 0.12 vs 0.80 Æ 0.13 mmol/L), whereas the sex ratio M/F was higher in severe and critical form (p<0.001). In a bivariate analysis, the risk of magnesium deficiency was significantly and negatively associated with infection severity (p<0.001), sex ratio (M/F, p<0.001), oxygenotherapy (p<0.001), stay in critical care unit (p=0.028), and positively with nephropathy (p=0.026).
    [Show full text]
  • Kellie ID Emergencies.Pptx
    4/24/11 ID Alert! recognizing rapidly fatal infections Susan M. Kellie, MD, MPH Professor of Medicine Division of Infectious Diseases, UNMSOM Hospital Epidemiologist UNMHSC and NMVAHCS Fever and…. Rash and altered mental status Rash Muscle pain Lymphadenopathy Hypotension Shortness of breath Recent travel Abdominal pain and diarrhea Case 1. The cross-country trucker A 30 year-old trucker driving from Oklahoma to California is hospitalized in Deming with fever and headache He is treated with broad-spectrum antibiotics, but deteriorates with obtundation, low platelet count, and a centrifugal petechial rash and is transferred to UNMH 1 4/24/11 What is your diagnosis? What is the differential diagnosis of fever and headache with petechial rash? (in the US) Tickborne rickettsioses ◦ RMSF Bacteria ◦ Neisseria meningitidis Key diagnosis in this case: “doxycycline deficiency” Key vector-borne rickettsioses treated with doxycycline: RMSF-case-fatality 5-10% ◦ Fever, nausea, vomiting, myalgia, anorexia and headache ◦ Maculopapular rash progresses to petechial after 2-4 days of fever ◦ Occasionally without rash Human granulocytotropic anaplasmosis (HGA): case-fatality<1% Human monocytotropic ehrlichiosis (HME): case fatality 2-3% 2 4/24/11 Lab clues in rickettsioses The total white blood cell (WBC) count is typicallynormal in patients with RMSF, but increased numbers of immature bands are generally observed. Thrombocytopenia, mild elevations in hepatic transaminases, and hyponatremia might be observed with RMSF whereas leukopenia
    [Show full text]
  • WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/05 (2006.01) A61P 31/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/CA20 14/000 174 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 4 March 2014 (04.03.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 13/790,91 1 8 March 2013 (08.03.2013) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: LABORATOIRE M2 [CA/CA]; 4005-A, rue kind of regional protection available): ARIPO (BW, GH, de la Garlock, Sherbrooke, Quebec J1L 1W9 (CA). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: LEMIRE, Gaetan; 6505, rue de la fougere, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Sherbrooke, Quebec JIN 3W3 (CA).
    [Show full text]
  • A Clinical Case of Fournier's Gangrene: Imaging Ultrasound
    J Ultrasound (2014) 17:303–306 DOI 10.1007/s40477-014-0106-5 CASE REPORT A clinical case of Fournier’s gangrene: imaging ultrasound Marco Di Serafino • Chiara Gullotto • Chiara Gregorini • Claudia Nocentini Received: 24 February 2014 / Accepted: 17 March 2014 / Published online: 1 July 2014 Ó Societa` Italiana di Ultrasonologia in Medicina e Biologia (SIUMB) 2014 Abstract Fournier’s gangrene is a rapidly progressing Introduction necrotizing fasciitis involving the perineal, perianal, or genital regions and constitutes a true surgical emergency Fournier’s gangrene is an acute, rapidly progressive, and with a potentially high mortality rate. Although the diagnosis potentially fatal, infective necrotizing fasciitis affecting the of Fournier’s gangrene is often made clinically, emergency external genitalia, perineal or perianal regions, which ultrasonography and computed tomography lead to an early commonly affects men, but can also occur in women and diagnosis with accurate assessment of disease extent. The children [1]. Although originally thought to be an idio- Authors report their experience in ultrasound diagnosis of pathic process, Fournier’s gangrene has been shown to one case of Fournier’s gangrene of testis illustrating the main have a predilection for patients with state diabetes mellitus sonographic signs and imaging diagnostic protocol. as well as long-term alcohol misuse. However, it can also affect patients with non-obvious immune compromise. Keywords Fournier’s gangrene Á Sonography Comorbid systemic disorders are being identified more and more in patients with Fournier’s gangrene. Diabetes mel- Riassunto La gangrena di Fournier e` una fascite necro- litus is reported to be present in 20–70 % of patients with tizzante a rapida progressione che coinvolge il perineo, le Fournier’s Gangrene [2] and chronic alcoholism in regioni perianale e genitali e costituisce una vera emer- 25–50 % patients [3].
    [Show full text]
  • The Care of a Patient with Fournier's Gangrene
    CASE REPORT The care of a patient with Fournier’s gangrene Esma Özşaker, Asst. Prof.,1 Meryem Yavuz, Prof.,1 Yasemin Altınbaş, MSc.,1 Burçak Şahin Köze, MSc.,1 Birgül Nurülke, MSc.2 1Department of Surgical Nursing, Ege University Faculty of Nursing, Izmir; 2Department of Urology, Ege University Faculty of Medicine Hospital, Izmir ABSTRACT Fournier’s gangrene is a rare, necrotizing fasciitis of the genitals and perineum caused by a mixture of aerobic and anaerobic microor- ganisms. This infection leads to complications including multiple organ failure and death. Due to the aggressive nature of this condition, early diagnosis is crucial. Treatment involves extensive soft tissue debridement and broad-spectrum antibiotics. Despite appropriate therapy, mortality is high. This case report aimed to present nursing approaches towards an elderly male patient referred to the urology service with a diagnosis of Fournier’s gangrene. Key words: Case report; Fournier’s gangrene; nursing diagnosis; patient care. INTRODUCTION Rarely observed in the peritoneum, genital and perianal re- perineal and genital regions, it is observed in a majority of gions, necrotizing fasciitis is named as Fournier’s gangrene.[1-5] cases with general symptoms, such as fever related infection It is an important disease, following an extremely insidious and weakness, and without symptoms in the perineal region, beginning and causing necrosis of the scrotum and penis by negatively influencing the prognosis by causing a delay in diag- advancing rapidly within one-two days.[1] The rate of mortal- nosis and treatment.[2,3] Consequently, anamnesis and physical ity in the literature is between 4 and 75%[6] and it has been examination are extremely important.
    [Show full text]
  • Non-Certified Epididymitis DST.Pdf
    Clinical Prevention Services Provincial STI Services 655 West 12th Avenue Vancouver, BC V5Z 4R4 Tel : 604.707.5600 Fax: 604.707.5604 www.bccdc.ca BCCDC Non-certified Practice Decision Support Tool Epididymitis EPIDIDYMITIS Testicular torsion is a surgical emergency and requires immediate consultation. It can mimic epididymitis and must be considered in all people presenting with sudden onset, severe testicular pain. Males less than 20 years are more likely to be diagnosed with testicular torsion, but it can occur at any age. Viability of the testis can be compromised as soon as 6-12 hours after the onset of sudden and severe testicular pain. SCOPE RNs must consult with or refer all suspect cases of epididymitis to a physician (MD) or nurse practitioner (NP) for clinical evaluation and a client-specific order for empiric treatment. ETIOLOGY Epididymitis is inflammation of the epididymis, with bacterial and non-bacterial causes: Bacterial: Chlamydia trachomatis (CT) Neisseria gonorrhoeae (GC) coliforms (e.g., E.coli) Non-bacterial: urologic conditions trauma (e.g., surgery) autoimmune conditions, mumps and cancer (not as common) EPIDEMIOLOGY Risk Factors STI-related: condomless insertive anal sex recent CT/GC infection or UTI BCCDC Clinical Prevention Services Reproductive Health Decision Support Tool – Non-certified Practice 1 Epididymitis 2020 BCCDC Non-certified Practice Decision Support Tool Epididymitis Other considerations: recent urinary tract instrumentation or surgery obstructive anatomic abnormalities (e.g., benign prostatic
    [Show full text]
  • IHS National Pharmacy & Therapeutics Committee National
    IHS National Pharmacy & Therapeutics Committee National Core Formulary; Last Updated: 09/23/2021 **Note: Medications in GREY indicate removed items.** Generic Medication Name Pharmacological Category (up-to-date) Formulary Brief (if Notes / Similar NCF Active? available) Miscellaneous Medications Acetaminophen Analgesic, Miscellaneous Yes Albuterol nebulized solution Beta2 Agonist Yes Albuterol, metered dose inhaler Beta2 Agonist NPTC Meeting Update *Any product* Yes (MDI) (Nov 2017) Alendronate Bisphosphonate Derivative Osteoporosis (2016) Yes Allopurinol Antigout Agent; Xanthine Oxidase Inhibitor Gout (2016) Yes Alogliptin Antidiabetic Agent, Dipeptidyl Peptidase 4 (DPP-4) Inhibitor DPP-IV Inhibitors (2019) Yes Anastrozole Antineoplastic Agent, Aromatase Inhibitor Yes Aspirin Antiplatelet Agent; Nonsteroidal Anti-Inflammatory Drug; Salicylate Yes Azithromycin Antibiotic, Macrolide STIs - PART 1 (2021) Yes Calcium Electrolyte supplement *Any formulation* Yes Carbidopa-Levodopa (immediate Anti-Parkinson Agent; Decarboxylase Inhibitor-Dopamine Precursor Parkinson's Disease Yes release) (2019) Clindamycin, topical ===REMOVED from NCF=== (See Benzoyl Peroxide AND Removed January No Clindamycin, topical combination) 2020 Corticosteroid, intranasal Intranasal Corticosteroid *Any product* Yes Cyanocobalamin (Vitamin B12), Vitamin, Water Soluble Hematologic Supplements Yes oral (2016) Printed on 09/25/2021 Page 1 of 18 National Core Formulary; Last Updated: 09/23/2021 Generic Medication Name Pharmacological Category (up-to-date) Formulary Brief
    [Show full text]
  • Neonatal Fournier's Gangrene; Sequelly of Traditional Birth Practice
    IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861. Volume 5, Issue 3 (Mar.- Apr. 2013), PP 01-03 www.iosrjournals.org Neonatal Fournier’s gangrene; sequelly of Traditional birth practice: Case report and Short Review 1 B.sc MBBs MCS10 HSE2&3, 2 Mukoro Duke George Tabowei B.I. MBBS, FMCS, 3 Olatoregun F MBBS FRCS,FWACS,FMCS. 1,2&3Department of Surgery, Niger-Delta University Teaching Hospital, Okolobiri, Yenogua, Bayelsa ,Nigeria. Abstract: Fournier’s gangrene is one of the infectious and gangrenous diseases seen worldwide ,It is commonly reported in Adult males but also in females. Injuries are nidus to its pathogenesis and many- microbes have been cultured from this clinical entity .This reported case was an incidental presentation resulting from obstetric care given by an unskilled personnel to a high risk pregnancy at term in prolonged labor. The case therefore avails clinician and pediatricians with the opportunity of seeing a rare adult tropical disease of the scrotum in a neonate. A fourteen day old term male baby presented with multiple perineal lacerations from delivery by a traditional birth attendant to the Surgery Unit. Perineum with scrotum and penis inclusive were noticed to be gangrenous .He was manage by debriment of necrotic tissue ,wound dressings , antiseptic solutions (gentian violent ,diluted H2O2)as well as intravenous antibiotics (ceftriaxone,ciprofloxacin, metronidazole,cloxacillin) ,syrup paracetamol and syrup camoquine ,however during the course of management ,parent had financial constraints . Fournier’s gangrene are rare phenomenon in neonates ,and could be a complication that may arise from poor resource countries or communities where traditional birth attendants and their practices strives.
    [Show full text]
  • Increased Mortality Associated with Hypermagnesemia in Severe COVID-19 Illness
    Original Investigation Increased Mortality Associated with Hypermagnesemia in Severe COVID-19 Illness Jacob S. Stevens 1,2, Andrew A. Moses1, Thomas L. Nickolas1,2, Syed Ali Husain1,2, and Sumit Mohan1,2,3 Key Points Hypermagnesemia is common in patients admitted with coronavirus disease 2019. The development of hypermagnesemia in coronavirus disease 2019 is associated with renal failure and markers of high cell turnover. In adjusted models, patients who develop hypermagnesemia have an increased risk of mortality. Abstract Background Although electrolyte abnormalities are common among patients with COVID-19, very little has been reported on magnesium homeostasis in these patients. Here we report the incidence of hypermagnesemia, and its association with outcomes among patients admitted with COVID-19. Methods We retrospectively identified all patients with a positive test result for SARS-CoV-2who were admitted to a large quaternary care center in New York City in spring 2020. Details of the patients’ demographics and hospital course were obtained retrospectively from medical records. Patients were defined as having hypermagnesemia if their median magnesium over the course of their hospitalization was .2.4 mg/dl. Results A total of 1685 patients hospitalized with COVID-19 had their magnesium levels checked during their hospitalization, and were included in the final study cohort, among whom 355 (21%) had hypermagnesemia. Patients who were hypermagnesemic had a higher incidence of shock requiring pressors (35% vs 27%, P,0.01), respiratory failure requiring mechanical ventilation (28% vs 21%, P50.01), AKI (65% vs 50%, P,0.001), and AKI severe enough to require renal replacement therapy (18% vs 5%, P,0.001).
    [Show full text]
  • Case Report Fournier's Gangrene
    Bone Marrow Transplantation, (1998) 22, 1023–1026 1998 Stockton Press All rights reserved 0268–3369/98 $12.00 http://www.stockton-press.co.uk/bmt Case report Fournier’s gangrene: a clinical presentation of necrotizing fasciitis after bone marrow transplantation G Martinelli1, EP Alessandrino1, P Bernasconi1, D Caldera1, A Colombo1, L Malcovati1, MR Gaviglio2, GP Vignoli2, G Borroni2 and C Bernasconi1 1Centro Trapianti di Midollo Osseo, Istituto di Ematologia, and 2Clinica Dermatologica, IRCCS Policlinico S Matteo, Pavia, Italy Summary: BMT (allo-BMT); the third an auto-BMT; all were suffer- ing from acute non-lymphocytic leukemia (ANLL). Three patients with ANLL developed Fournier’s gang- rene as an early complication after allo-BMT (two cases) and auto-BMT (one case); two patients were in Case reports first CR, the third had resistant disease. Patients developed fever, perineal pain, swelling and blistering Case No. 1 of the genital area. Pseudomonas aeruginosa was iso- A 41-year-old male, with ANLL in first hematological com- lated from the lesions and patients received systemic antibiotic therapy, surgical debridement and medication plete remission (CR), underwent allo-BMT from an HLA identical sibling donor. Pre-transplant tests showed normal with potassium permanganate solution. Two patients renal and hepatic function; chest X-ray revealed evidence made a complete recovery although one died of sepsis. The third had progressive involvement of the abdominal of a previous right pleuritis; ECG and echocardiography were normal. Performance status was good and clinical wall and later died of leukemia. Early diagnosis of this disorder and prompt initiation of appropriate therapy examination was negative.
    [Show full text]
  • Early-Onset Neonatal Hyperkalemia Associated with Maternal
    Tanaka et al. BMC Pediatrics (2018) 18:55 https://doi.org/10.1186/s12887-018-1048-4 CASEREPORT Open Access Early-onset neonatal hyperkalemia associated with maternal hypermagnesemia: a case report Kenichi Tanaka1, Hiroko Mori1, Rieko Sakamoto2, Shirou Matsumoto2, Hiroshi Mitsubuchi1, Kimitoshi Nakamura2 and Masanori Iwai1* Abstract Background: Neonatal nonoliguric hyperkalemia (NOHK) is a metabolic abnormality that occurs in extremely premature neonates at approximately 24 h after birth and is mainly due to the immature functioning of the sodium (Na+)/potassium (K+) pump. Magnesium sulfate is frequently used in obstetrical practice to prevent preterm labor and to treat preeclampsia; this medication can also cause hypermagnesemia and hyperkalemia by a mechanism that is different from that of NOHK. Herein, we report the first case of very early-onset neonatal hyperkalemia induced by maternal hypermagnesemia. Case presentation: A neonate born at 32 weeks of gestation developed hyperkalemia (K+ 6.4 mmol/L) 2 h after birth. The neonate’s blood potassium concentration reached 7.0 mmol/L 4 h after birth, despite good urine output. The neonate and his mother had severe hypermagnesemia caused by intravenous infusion of magnesium sulfate given for tocolysis due to pre-term labor. Conclusion: The early-onset hyperkalemia may have been caused by the accumulation of potassium ions transported through the placenta, the shift of potassium ions from the intracellular to the extracellular space in the infant due to the malfunctioning of the Na+/K+ pump and the inhibition of renal distal tube potassium ion secretion, there is a possibility that these mechanisms were induced by maternal and fetal hypermagnesemia after maternal magnesium sulfate administration.
    [Show full text]
  • Drugs Affectin the Autonomic Nervous System
    Fundamentals of Medical Pharmacology Paterson Public Schools Written by Néstor Collazo, Ph.D. Jonathan Hodges, M.D. Tatiana Mikhaelovsky, M.D. for Health and Related Professions (H.A.R.P.) Academy March 2007 Course Description This fourth year course is designed to give students in the Health and Related Professions (H.A.R.P.) Academy a general and coherent explanation of the science of pharmacology in terms of its basic concepts and principles. Students will learn the properties and interactions between chemical agents (drugs) and living organisms for the rational and safe use of drugs in the control, prevention, and therapy of human disease. The emphasis will be on the fundamental concepts as they apply to the actions of most prototype drugs. In order to exemplify important underlying principles, many of the agents in current use will be singled out for fuller discussion. The course will include the following topics: ¾ The History of Pharmacology ¾ Terminology Used in Pharmacology ¾ Drug Action on Living Organisms ¾ Principles of Pharmacokinetics ¾ Dose-Response Relationships ¾ Time-Response Relationships ¾ Human Variability: Factors that will modify effects of drugs on individuals ¾ Effects of Drugs Attributable to Varying Modes of Administration ¾ Drug Toxicity ¾ Pharmacologic Aspects of Drug Abuse and Drug Dependence Pre-requisites Students must have completed successfully the following courses: Biology, Chemistry, Anatomy and Physiology, Algebra I and II Credits: 5 credits Basic Principles of Drug Action Introduction to Pharmacology a. Basic Mechanisms of Drug Actions b. Dose-response relationships c. Drug absorption d. Biotransformation of Drugs e. Pharmacokinetics f. Factors Affecting Drug Distribution g. Drug Allergy and Pharmacogenetics h.
    [Show full text]