Carcinogens and Reproductive Toxicants
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Safety Data Sheet
SAFETY DATA SHEET 1. Product and Company Identification Product identifier SSS O3 Professional Cleaning System Other means of identification O3 Professional Cleaning System Ozonated Water Recommended use Not available. Recommended restrictions None known. Manufacturer/Importer/Supplier/Distributor information Manufacturer Company name Tersano Inc. Address 5000 Regal Drive Oldcastle, ON N0R 1A0 Canada Telephone 1-800-808-1723 (Toll-Free) Website www.tersano.com E-mail [email protected] Emergency phone number 1-800-808-1723 (Toll-Free) 2. Hazards Identification Physical hazards Not classified. Health hazards Not classified. Environmental hazards Not classified. OSHA defined hazards Not classified. Label elements Hazard symbol None. Signal word None. Hazard statement The mixture does not meet the criteria for classification. Precautionary statement Prevention Observe good industrial hygiene practices. Response Not applicable. Storage Not applicable. Disposal No special precautions required. Hazard(s) not otherwise None known. classified (HNOC) Supplemental information Not applicable. 3. Composition/Information on Ingredients Mixtures Chemical name Common name and synonyms CAS number % Water 7732-18-5 >99.99 Ozone 10028-15-6 <0.01 4. First Aid Measures Inhalation Not applicable. Skin contact Not applicable. Eye contact Not applicable. Ingestion Not applicable. Most important This material is not expected to be harmful. symptoms/effects, acute and delayed #25447 Page: 1 of 6 Issue date 17-December-2014 LBUxxx, LSRxxx, LSCxxx, LQFCxxx Indication of immediate Treat symptomatically. medical attention and special treatment needed General information Ensure that medical personnel are aware of the material(s) involved, and take precautions to protect themselves. 5. Fire Fighting Measures Suitable extinguishing media Not applicable, non-combustible. -
Exposure to Carcinogens and Work-Related Cancer: a Review of Assessment Methods
European Agency for Safety and Health at Work ISSN: 1831-9343 Exposure to carcinogens and work-related cancer: A review of assessment methods European Risk Observatory Report Exposure to carcinogens and work-related cancer: A review of assessment measures Authors: Dr Lothar Lißner, Kooperationsstelle Hamburg IFE GmbH Mr Klaus Kuhl (task leader), Kooperationsstelle Hamburg IFE GmbH Dr Timo Kauppinen, Finnish Institute of Occupational Health Ms Sanni Uuksulainen, Finnish Institute of Occupational Health Cross-checker: Professor Ulla B. Vogel from the National Working Environment Research Centre in Denmark Project management: Dr Elke Schneider - European Agency for Safety and Health at Work (EU-OSHA) Europe Direct is a service to help you find answers to your questions about the European Union Freephone number (*): 00 800 6 7 8 9 10 11 (*) Certain mobile telephone operators do not allow access to 00 800 numbers, or these calls may be billed. More information on the European Union is available on the Internet ( 48TU http://europa.euU48T). Cataloguing data can be found on the cover of this publication. Luxembourg: Publications Office of the European Union, 2014 ISBN: 978-92-9240-500-7 doi: 10.2802/33336 Cover pictures: (clockwise): Anthony Jay Villalon (Fotolia); ©Roman Milert (Fotolia); ©Simona Palijanskaite; ©Kari Rissa © European Agency for Safety and Health at Work, 2014 Reproduction is authorised provided the source is acknowledged. European Agency for Safety and Health at Work – EU-OSHA 1 Exposure to carcinogens and work-related cancer: -
Ammonia Solution.Pdf
SAFETY DATA SHEET Creation Date 23-Nov-2009 Revision Date 13-Apr-2015 Revision Number 4 SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1. Product identification Product Description: Ammonia solution 35% Cat No. : A/3240/PB15, A/3240/PB17 Molecular Formula H5 N O 1.2. Relevant identified uses of the substance or mixture and uses advised against Recommended Use Laboratory chemicals. Uses advised against No Information available 1.3. Details of the supplier of the safety data sheet Company Fisher Scientific UK Bishop Meadow Road, Loughborough, Leicestershire LE11 5RG, United Kingdom E-mail address [email protected] 1.4. Emergency telephone number Chemtrec US: (800) 424-9300 Chemtrec EU: 001 (202) 483-7616 Tel: 01509 231166 SECTION 2: HAZARDS IDENTIFICATION 2.1. Classification of the substance or mixture CLP Classification - Regulation (EC) No 1272/2008 Physical hazards Based on available data, the classification criteria are not met Health hazards Skin Corrosion/irritation Category 1 B Serious Eye Damage/Eye Irritation Category 1 Specific target organ toxicity - (single exposure) Category 3 Environmental hazards Acute aquatic toxicity Category 1 Classification according to EU Directives 67/548/EEC or 1999/45/EC Symbol(s) C - Corrosive N - Dangerous for the environment R-phrase(s) R34 - Causes burns R50 - Very toxic to aquatic organisms For the full text of the R-phrases and H-Statements mentioned in this Section, see Section 16. ______________________________________________________________________________________________ -
Toxicological Profile for Radon
RADON 205 10. GLOSSARY Some terms in this glossary are generic and may not be used in this profile. Absorbed Dose, Chemical—The amount of a substance that is either absorbed into the body or placed in contact with the skin. For oral or inhalation routes, this is normally the product of the intake quantity and the uptake fraction divided by the body weight and, if appropriate, the time, expressed as mg/kg for a single intake or mg/kg/day for multiple intakes. For dermal exposure, this is the amount of material applied to the skin, and is normally divided by the body mass and expressed as mg/kg. Absorbed Dose, Radiation—The mean energy imparted to the irradiated medium, per unit mass, by ionizing radiation. Units: rad (rad), gray (Gy). Absorbed Fraction—A term used in internal dosimetry. It is that fraction of the photon energy (emitted within a specified volume of material) which is absorbed by the volume. The absorbed fraction depends on the source distribution, the photon energy, and the size, shape and composition of the volume. Absorption—The process by which a chemical penetrates the exchange boundaries of an organism after contact, or the process by which radiation imparts some or all of its energy to any material through which it passes. Self-Absorption—Absorption of radiation (emitted by radioactive atoms) by the material in which the atoms are located; in particular, the absorption of radiation within a sample being assayed. Absorption Coefficient—Fractional absorption of the energy of an unscattered beam of x- or gamma- radiation per unit thickness (linear absorption coefficient), per unit mass (mass absorption coefficient), or per atom (atomic absorption coefficient) of absorber, due to transfer of energy to the absorber. -
Toxicological Profile for Hydrazines. US Department Of
TOXICOLOGICAL PROFILE FOR HYDRAZINES U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry September 1997 HYDRAZINES ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. HYDRAZINES iii UPDATE STATEMENT Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333 HYDRAZINES vii CONTRIBUTORS CHEMICAL MANAGER(S)/AUTHOR(S): Gangadhar Choudhary, Ph.D. ATSDR, Division of Toxicology, Atlanta, GA Hugh IIansen, Ph.D. ATSDR, Division of Toxicology, Atlanta, GA Steve Donkin, Ph.D. Sciences International, Inc., Alexandria, VA Mr. Christopher Kirman Life Systems, Inc., Cleveland, OH THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS: 1 . Green Border Review. Green Border review assures the consistency with ATSDR policy. 2 . Health Effects Review. The Health Effects Review Committee examines the health effects chapter of each profile for consistency and accuracy in interpreting health effects and classifying end points. 3. Minimal Risk Level Review. The Minimal Risk Level Workgroup considers issues relevant to substance-specific minimal risk levels (MRLs), reviews the health effects database of each profile, and makes recommendations for derivation of MRLs. HYDRAZINES ix PEER REVIEW A peer review panel was assembled for hydrazines. The panel consisted of the following members: 1. Dr. -
Remedy®️ Ultra
SAFETY DATA SHEET DOW AGROSCIENCES LLC Product name: REMEDY™ ULTRA Herbicide Issue Date: 06/10/2020 Print Date: 06/10/2020 DOW AGROSCIENCES LLC encourages you and expects you to read and understand the entire SDS as there is important information throughout the document. This SDS provides users with information relating to the protection of human health and safety at the workplace, protection of the environment and supports emergency response. Product users and applicators should primarily refer to the product label attached to or accompanying the product container. 1. IDENTIFICATION Product name: REMEDY™ ULTRA Herbicide Recommended use of the chemical and restrictions on use Identified uses: End use herbicide product COMPANY IDENTIFICATION DOW AGROSCIENCES LLC 9330 ZIONSVILLE RD INDIANAPOLIS IN 46268-1053 UNITED STATES Customer Information Number: 800-992-5994 [email protected] EMERGENCY TELEPHONE NUMBER 24-Hour Emergency Contact: 800-992-5994 Local Emergency Contact: 352-323-3500 2. HAZARDS IDENTIFICATION Hazard classification GHS classification in accordance with 29 CFR 1910.1200 Skin sensitisation - Sub-category 1B Specific target organ toxicity - repeated exposure - Category 2 Label elements Hazard pictograms Signal word: WARNING! ® ™ Trademarks of Dow AgroSciences, DuPont or Pioneer and their affiliated 1/14 companies or respective owners. Product name: REMEDY™ ULTRA Herbicide Issue Date: 06/10/2020 Hazards May cause an allergic skin reaction. May cause damage to organs (Kidney) through prolonged or repeated exposure. Precautionary statements Prevention Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Response IF ON SKIN: Wash with plenty of soap and water. -
Material Safety Data Sheet
MATERIAL SAFETY DATA SHEET Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards PART I What is the material and what do I need to know in an emergency? 1. PRODUCT IDENTIFICATION TRADE NAME (AS LABELED) : MERCURY CHEMICAL NAME/CLASS : Mercury; Element SYNONYMS: Colloidal Mercury, Quick Silver; Liquid Silver; NCI-C60399; Hydrargyrum PRODUCT USE : Variety of industrial, analytical, and research applications. SUPPLIER/MANUFACTURER'S NAME : COMPANY ADDRESS : DFG MERCURY CORP 909 pitner Evanston Ill 60202 EMERGENCY PHONE : 1 800 424 9300 BUSINESS PHONE : 1 847 869 7800 DATE OF PREPARATION : May 20, 1997 DATE OF REVISION : October 7, 2013 2. COMPOSITION and INFORMATION ON INGREDIENTS CHEMICAL NAME CAS # %w/w EXPOSURE LIMITS IN AIR ACGIH-TLV OSHA-PEL OTHER TWA STEL TWA STEL IDLH mg/m 3 mg/m 3 mg/m 3 mg/m 3 mg/m 3 mg/m 3 Mercury 7439-97-6 100 0.025, (skin) NE Mercury 0.1 (ceiling) 10 NIOSH REL: Exposure limits are A4 (Not Vapor: 0.5, STEL = 0.1 (ceiling, for Mercury, Classifiable Skin; Non-alkyl Mercury skin) Inorganic as a Human (Vacated Compounds: 0.1 DFG MAKs: Compounds Carcinogen) 1989 PEL) Ceiling, skin TWA = 0.1 (Vacated 1989 PEAK = 10 •MAK 30 PEL) min., momentary value Carcinogen: EPA-D; IARC-3, TLV-A4 NE = Not Established. See Section 16 for Definitions of Terms Used. NOTE: ALL WHMIS required information is included in appropriate sections based on the ANSI Z400.1-1998 format. This product has been classified in accordance with the hazard criteria of the CPR and the MSDS contains all the information required by the CPR. -
Detection of Carcinogens As Mutagens in the Salmonella/Microsome Test
Proc. Nat. Acad. Sci. USA Vol. 73, No. 3, pp. 950-954, March 1976 Medical Sciences Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals: Discussion* (prevention of cancer and genetic defects/somatic mutation/environmental insult to DNA) JOYCE MCCANN AND BRUCE N. AMES Department of Biochemistry, University of California, Berkeley, Calif. 94720 Contributed by Bruce N. Ames, January 7, 1976 ABSTRACT About 300 carcinogens and non-carcinogens Non-Carcinogens. Classification as to non-carcinogenicity of a wide variety of chemical types have been tested for mu- is usually difficult because of the varying completeness and tagenicity in the simple Salmonella/microsome test. The test uses bacteria as sensitive indicators of DNA damage, and modes of treatment in many studies and the statistical limi- mammalian liver extracts for metabolic conversion of carcin- tations inherent in animal tests (4, 8-10). Recent criteria for ogens to their active mutagenic forms. There is a high corre- adequate carcinogenicity tests are much more stringent (4, lation between carcinogenicity and mutagenicity: 90% 8-10). The test should be of adequate duration (lifetime pre- (157/175) of the carcinogens were mutagenic in the test, in- ferred in rodents) in at least two animal species, at several cluding almost all of the known human carcinogens that dose levels, and positive controls should be of the same gen- were tested. Despite the severe limitations inherent in defin- ing non-carcinogenicity, few "non-carcinogens" showed any eral chemical type as the chemical under test. The applica- degree of mutagenicity [McCann et a]. (1975) Proc. -
Lead, Mercury and Cadmium in Fish and Shellfish from the Indian Ocean and Red
Journal of Marine Science and Engineering Review Lead, Mercury and Cadmium in Fish and Shellfish from the Indian Ocean and Red Sea (African Countries): Public Health Challenges Isidro José Tamele 1,2,3,* and Patricia Vázquez Loureiro 4 1 Department of Chemistry, Faculty of Sciences, Eduardo Mondlane University, Av. Julius Nyerere, n 3453, Campus Principal, Maputo 257, Mozambique 2 Institute of Biomedical Science Abel Salazar, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal 3 CIIMAR/CIMAR—Interdisciplinary Center of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto, Avenida General Norton de Matos, 4450-238 Matosinhos, Portugal 4 Department of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, 15782 A Coruña, Spain; [email protected] * Correspondence: [email protected] Received: 20 March 2020; Accepted: 8 May 2020; Published: 12 May 2020 Abstract: The main aim of this review was to assess the incidence of Pb, Hg and Cd in seafood from African countries on the Indian and the Red Sea coasts and the level of their monitoring and control, where the direct consumption of seafood without quality control are frequently due to the poverty in many African countries. Some seafood from African Indian and the Red Sea coasts such as mollusks and fishes have presented Cd, Pb and Hg concentrations higher than permitted limit by FAOUN/EU regulations, indicating a possible threat to public health. Thus, the operationalization of the heavy metals (HM) monitoring and control is strongly recommended since these countries have laboratories with minimal conditions for HM analysis. -
Food-Derived Mutagens and Carcinogens1
[CANCER RESEARCH (SL'PPL.) 52. 2092s-2098s. April I, 1992] Food-derived Mutagens and Carcinogens1 Keiji Wakabayashi,2 Minako Nagao, Hiroyasu Esumi, and Takashi Sugimura National Cancer Center Research Institute, l-l, Tsukiji 5-chome, Chuo-ku, Tokyo 104, Japan Abstract pounds have planar structures that can be inserted between the base pairs of double-stranded DNA. Charred parts of broiled Cooked food contains a variety of mutagenic heterocyclic amines. All the mutagenic heterocyclic amines tested were carcinogenic in rodents fish and meat were also found to be mutagenic to TA98 after when given in the diet at 0.01-0.08%. Most of them induced cancer in metabolic activation (9, 10). These findings led to the isolations the liver and in other organs. It is noteworthy that the most abundant of the mutagenic compounds, IQ,' MelQ, MelQx from broiled heterocyclic amine in cooked food, 2-amino-l-methyl-6-phenylimi- fish and meat (5-7). Later PhIP was also isolated as member dazo(4,5-A|pyridine, produced colon and mammary carcinomas of this class of mutagens (11). These heterocyclic amines were in rats and lymphomas in mice but no hepatomas in either. 2-Amino-3- methylimidazo(4,5-/]quinoline induced liver cancer in monkeys. Forma formed by heating mixtures of creatinine, sugars, and amino acids, which are present in raw meat and fish (12-16). More tion of adducts with guanine by heterocyclic amines is presumably involved in their carcinogenesis. Quantification of heterocyclic amines in recently identified mutagens have been found to contain oxygen cooked foods and in human urine indicated that humans are continuously atoms (17-19). -
Persistent Organic Pollutants
PERSISTENT ORGANIC POLLUTANTS An Assessment Report on: DDT-Aldrin-Dieldrin-Endrin-Chlordane Heptachlor-Hexachlorobenzene Mirex-Toxaphene Polychlorinated Biphenyls Dioxins and Furans Prepared by: L. Ritter, K.R. Solomon, J. Forget Canadian Network of Toxicology Centres 620 Gordon Street Guelph ON Canada and M. Stemeroff and C.O'Leary Deloitte and Touche Consulting Group 98 Macdonell St., Guelph ON Canada For: The International Programme on Chemical Safety (IPCS) within the framework of the Inter-Organization Programme for the Sound Management of Chemicals (IOMC) This report is produced for the International Programme on Chemical Safety (IPCS). The work is carried out within the framework of the Inter-Organization Programme for the Sound Management of Chemicals (IOMC). The report does not necessarily represent the decisions or the stated policy of the United Nations Environment Programme, the International Labour Organisation, or the World Health Organization. The International Programme on Chemical Safety (IPCS) is a joint venture of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. The main objective of the IPCS is to carry out and disseminate evaluations of the effects of chemicals on human health and the quality of the environment. Supporting activities include the development of epidemiological, experimental laboratory, and risk-assessment methods that could produce internationally comparable results, and the development of human resources in the field of chemical safety. Other activities carried out by the IPCS include the development of know-how for coping with chemical accidents, strengthening capabilities for prevention of an response to chemical accidents and their follow-up, coordination of laboratory testing and epidemiological studies, and promotion of research on the mechanisms of the biological action of chemicals. -
Toxicological Profile for Chlorine
CHLORINE 159 6. POTENTIAL FOR HUMAN EXPOSURE 6.1 OVERVIEW Although it has multiple uses and is released to the environment, chlorine is too reactive to be identified in any of the 1,704 hazardous waste sites that have been proposed for inclusion on the EPA National Priorities List (NPL) (HazDat 2007). Chlorine may be released into the environment during accidents such as a chlorine gas leak from an industrial facility or a chlorine tank spill or rupture. Low concentrations of chlorine gas (<600 ppt) appear to be produced by the photolysis of seawater aerosol. Chlorine gas injected into the water during water chlorination quickly dissolves and forms chloride and hypochlorous acid within seconds. Liquid chlorine in a ruptured tank or spilled onto the ground or into water during an accident is expected to volatilize rapidly, forming a greenish-yellow cloud of chlorine gas. This gas cloud can be carried several miles away from the source of release while maintaining dangerous levels of chlorine. Since chlorine gas is so reactive, it is not expected to remain in the environment very long after it is released. Chlorine immediately reacts with both organic and inorganic materials that it comes into contact with. As mentioned above, it is converted within seconds once it dissolves in water. Chlorine undergoes direct photolysis in the air and its half-life in the troposphere is on the order of several minutes. Chlorine levels in the ambient atmosphere, water, soil, or sediment are not available. Exposure of the general population to chlorine gas is not expected except in the case of an accidental spill or industrial mishap.