International Journal of Molecular Sciences Article C9orf72 Intermediate Repeats Confer Genetic Risk for Severe COVID-19 Pneumonia Independently of Age Isabella Zanella 1,2,*,†,‡ , Eliana Zacchi 3,4,‡, Simone Piva 5,6,‡, Massimiliano Filosto 3,7,‡ , Giada Beligni 8,9,†, Diana Alaverdian 8,9,†, Sara Amitrano 10,†, Francesca Fava 8,9,10,† , Margherita Baldassarri 8,9,† , Elisa Frullanti 8,9,†, Ilaria Meloni 8,9,†, Alessandra Renieri 8,9,10,† , GEN-COVID Multicenter Study †, GEVACOBA Study Group ‡, Francesco Castelli 3,4,†,‡ and Eugenia Quiros-Roldan 3,4,†,‡ 1 Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy 2 Clinical Chemistry Laboratory, Cytogenetics and Molecular Genetics Section, Diagnostic Department, ASST Spedali Civili di Brescia, 25123 Brescia, Italy 3 Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy;
[email protected] (E.Z.); massimiliano.fi
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[email protected] (E.Q.-R.) 4 Division of Infectious and Tropical Diseases, ASST Spedali Civili di Brescia, 25123 Brescia, Italy 5 University Division of Anesthesiology and Critical Care Medicine, ASST Spedali Civili, 25123 Brescia, Italy;
[email protected] 6 Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25123 Brescia, Italy 7 NeMo-Brescia Clinical Center for Neuromuscular Diseases, 25064 Gussago, Italy 8 Medical Genetics, Department of Medical Biotechnologies,