PCGF6-PRC1 Suppresses Premature Differentiation of Mouse Embryonic
RESEARCH ARTICLE PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes Mitsuhiro Endoh1,2,3,4,5*, Takaho A Endo6, Jun Shinga7, Katsuhiko Hayashi8, Anca Farcas9, Kit-Wan Ma1, Shinsuke Ito1,2, Jafar Sharif1,2, Tamie Endoh1,3,5, Naoko Onaga1, Manabu Nakayama10, Tomoyuki Ishikura1, Osamu Masui1, Benedikt M Kessler11, Toshio Suda3,4, Osamu Ohara6,10, Akihiko Okuda12, Robert Klose9, Haruhiko Koseki1,2* 1Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; 2Core Research for Evolutional Science and Technology, Yokohama, Japan; 3Centre for Translational Medicine,Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; 4International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan; 5Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan; 6Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; 7Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; 8Department of Developmental Stem Cell Biology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; 9Department of Biochemistry, Oxford University, Oxford, United Kingdom; 10Chromosome Engineering Team, Department of Technology Development, Kazusa DNA Research Institute, Kisarazu, Japan; 11Mass Spectrometry Laboratory, Target Discovery Institute, Nuffield *For correspondence: csime@nus. Department
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