DOCSLIB.ORG

Novel Divergent Picornavirus:Cosavirus Neues Divergentes Picornavirus:Cosavirus Nouveau Picornavirus Divergent : Le Cosavirus

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Novel Divergent Picornavirus:Cosavirus Neues Divergentes Picornavirus:Cosavirus Nouveau Picornavirus Divergent : Le Cosavirus (19) TZZ _T (11) EP 2 274 447 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: C12Q 1/70 (2006.01) C12Q 1/68 (2006.01) 24.12.2014 Bulletin 2014/52 C12P 19/34 (2006.01) C12N 7/00 (2006.01) (21) Application number: 09721869.7 (86) International application number: PCT/US2009/037726 (22) Date of filing: 19.03.2009 (87) International publication number: WO 2009/117615 (24.09.2009 Gazette 2009/39) (54) NOVEL DIVERGENT PICORNAVIRUS:COSAVIRUS NEUES DIVERGENTES PICORNAVIRUS:COSAVIRUS NOUVEAU PICORNAVIRUS DIVERGENT : LE COSAVIRUS (84) Designated Contracting States: • Kapoor A et al.: "Characterization of a highly AT BE BG CH CY CZ DE DK EE ES FI FR GB GR divergent picornavirus prevalent in stool HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL samplesof children with acute flaccid paralysis.", PT RO SE SI SK TR International Conference on Emerging Infectious Diseases 2008: slide sessions and poster (30) Priority: 20.03.2008 US 38375 P abstracts, 17 March 2008 (2008-03-17), XP002638866, Retrieved from the Internet: URL: (43) Date of publication of application: http://www.cdc.gov/eid/content/14/3/IC 19.01.2011 Bulletin 2011/03 EID2008.pdf [retrieved on 2011-05-25] • SWENNEN B ET AL: "Oral poliomyelitis vaccine: (73) Proprietor: Blood Systems, Inc. time to change?", VACCINE, ELSEVIER LTD, GB, Scottsdale, AZ 85257 (US) vol. 19, no. 17-19, 21 March 2001 (2001-03-21), pages 2262-2267, XP004231033, ISSN: (72) Inventors: 0264-410X, DOI: DOI:10.1016/S0264-410X(00) • DELWART, Eric 00549-1 San Francisco, CA 94118 (US) • PARSHIONIKAR S U ET AL: "Development of • KAPOOR, Amit homologous viral internal controls for use in RT- Pacifica, CA 94044 (US) PCR assays of waterborne enteric viruses", • VICTORIA, Joseph JOURNAL OF VIROLOGICAL METHODS, San Francisco, CA 94115 (US) ELSEVIER BV, NL, vol. 121, no. 1, 1 October 2004 (2004-10-01), pages 39-48, XP004551403, ISSN: (74) Representative: Cornish, Kristina Victoria Joy et al 0166-0934, DOI: DOI:10.1016/J.JVIROMET. Kilburn & Strode LLP 2004.05.015 20 Red Lion Street • DATABASE GENBANK 02 March 2007 ’Theiler’s London WC1R 4PJ (GB) encephalomyelitis virus, complete genome’, XP008143467 Database accession no. (56) References cited: DQ401688.1 WO-A2-98/14611 US-A- 5 986 171 • KAPOOR ET AL.: ’A highly prevalent and US-A1- 2006 159 659 US-A1- 2006 240 466 genetically diversified Picomaviridae genus in SouthAsian children’ PROC NATL ACAD SCI (US) vol. 105, no. 51, 2008, pages 20482 - 20487, XP008143552 Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). EP 2 274 447 B1 Printed by Jouve, 75001 PARIS (FR) (Cont. next page) EP 2 274 447 B1 • DATABASE GENESEQ [Online] 21 September • FINKBEINER STACY R ET AL: ’Metagenomic 2006 ’SVV-like picornavirus 2C region DNA, SEQ analysis of human diarrhea: Viral detection and ID 181.’ Retrieved from EBI, accession no. GSN: discovery’ PLOS PATHOGENS vol. 4, no. 2, AEJ20306 Database accession no. AEJ20306 February 2008, ISSN: 1553-7366(print) • DATABASE GENESEQ [Online] 21 September 2006 ’Seneca Valley virus amino acid sequence, SEQ ID 40.’ Retrieved from EBI, accession no. GSP:AEJ20165 Database accession no. AEJ20165 2 1 EP 2 274 447 B1 2 Description picornaviruses. The complete amino acid sequence of Cosavirus type-1 (HCoSV-1) exhibits greater than 60% FIELD OF THE INVENTION diversity with known picornaviruses. Cosavirus type-1 is divergent enough from known picornaviruses to be as- [0001] The present invention relates generally to the 5 signed as the prototype member of a new genus in the discovery of a new human picornavirus virus and more Picornaviridae family.Also identified is the genomic se- specifically, to methods of detecting the virus and diag- quence of a species of Cosavirus, as well as partial ge- nosing viral infection, methods of treating or preventing nomic sequences of several other species of Cosavirus, virus infection, and methods for identifying anti-viral com- and the open-reading frame encoding viral proteins. Five pounds. 10 species of Cosavirus have been identified; A, B, C, D, and E. The present invention therefore provides methods BACKGROUND INFORMATION of detecting the Cosavirus and diagnosing Cosavirus in- fection in biological samples, methods of treating or pre- [0002] Picornaviridae are a large family of non-envel- venting Cosavirus infection, and methods for identifying oped, positive-sense RNA animal viruses, comprised of 15 antiviral compounds. six genera capable of infecting human (Enterovirus, [0007] Accordingly, in one embodiment of the present Parechovirus, Rhinovirus, Hepatovirus, Cardiovirus, and invention there are provided isolated nucleic acid mole- Aphthovirus) that contain more than 200 viral species cules isolated from Cosavirus. In certain embodiments, known to cause important diseases of humans and ani- the nucleic acid molecule is from Cosavirus species A, mals, including type A viral hepatitis, aseptic meningitis, 20 B, C, D, or E, or variants thereof. In particular embodi- chronic heart disease and the common cold. ments, the nucleic acid molecule comprises a nucleotide [0003] Acute flaccid paralysis (AFP) is a term that is sequence at least 80% identical to SEQ ID NO: 1, SEQ often used to describe a sudden onset of generalized or ID NO:3, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:9, symmetric limb weakness. AFP is associated with a SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:15, or SEQ number of pathogenic agents including enteroviruses, 25 ID NO:16. In some embodiments, the nucleotide se- echoviruses, and adenoviruses, among others. Howev- quence comprises a nucleotide sequence at least 90% er, existing molecular reagents frequently fail to identify identical to SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, the causative agent if it is a highly divergent variant of a SEQ ID NO:6, SEQ ID NO:9, SEQ ID NO:10, SEQ ID known virus or if it is a novel virus. NO:11, SEQ ID NO:15, or SEQ ID NO:16. In other em- [0004] Despite the known pathogenicity of picornavi- 30 bodiments, the nucleotide sequence comprises a nucle- ruses and the urgent need for methods to prevent, diag- otide sequence at least 95% identical to SEQ ID NO:1, nose and treat picornavirus infections, other divergent SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:6, SEQ ID human picornaviruses have not yet been identified. NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:15, Therefore, a need exists to detect divergent human pi- orSEQ ID NO:16. In oneaspect, the nucleotide sequence cornaviruses and to provide a method to diagnose, pre- 35 is selected from the group consisting of SEQ ID NO:1, ventand treat divergentpicornavirus infection. Moreover, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:6, SEQ ID there exists a need to provide methods to identify diver- NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:15, gent picornavirus antiviral compounds SEQ ID NO:16, and a complement thereof. In still other [0005] At the International Conference on emerging In- embodiments, the nucleotide sequence a fragment of at fectious Diseases held on 16-19 March 2008 at Atlanta, 40 least 50 nucleotides in length of any of the above nucleic Georgia, USA; A. Kapoor. et al. displayed on Board III acids. an abstract and results from their research on the "Char- [0008] In certain embodiments, the nucleic acid mole- acteri Zation of Highly Divergent Picornavirus Prevalent cule comprises a sequence that hybridizes under strin- in Stool Samples of Children with Acute Flaccid Paraly- gent conditions to at least 50 contiguous nucleotides of sis". The abstract related to a method for detecting the 45 the nucleotide sequence of SEQ ID NO:1, SEQ ID NO:3, presence of a Dekavirus (i.e. Cosavirus) in a stool sam- SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:9, SEQ ID ple. NO:10, SEQ ID NO:11, SEQ ID NO:15, SEQ ID NO:16, or a complement thereof. In particular embodiments, the SUMMARY OF THE INVENTION nucleic acid sequence hybridizes under stringent condi- 50 tions to at least 50, least 100, or at least 150 contiguous [0006] The present invention relates to the identifica- nucleotides of the the nucleotide sequence of SEQ ID tion of a new human picornavirus, Dekavirus (DKV), and NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:6, SEQ recently re-named Cosavirus (for Human Common Stool ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:15, Associated (or South Asia) picornavirus; HCoSV) in the SEQ ID NO:16, or a complement thereof. In one aspect, scientific literature. Accordingly, the name of the virus as 55 the nucleotide sequence hybridizes under highly strin- used herein has been updated to Cosavirus to reflect this gent conditions over the full length of the nucleotide se- change in name. The total nucleotide sequence of Cosa- quence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, virus is greater than 70% divergent from all described SEQ ID NO:6, SEQ ID NO:9, SEQ ID NO:10, SEQ ID 3 3 EP 2 274 447 B1 4 NO:11, SEQ ID NO:15, or SEQ ID NO:16, or a comple- virus comprising a nucleic acid of the invention.
Load more

Recommended publications
  • Computational Exploration of Virus Diversity on Transcriptomic Datasets
    Computational Exploration of Virus Diversity on Transcriptomic Datasets Digitaler Anhang der Dissertation zur Erlangung des Doktorgrades (Dr. rer. nat.) der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn vorgelegt von Simon Käfer aus Andernach Bonn 2019 Table of Contents 1 Table of Contents 1 Preliminary Work - Phylogenetic Tree Reconstruction 3 1.1 Non-segmented RNA Viruses ........................... 3 1.2 Segmented RNA Viruses ............................. 4 1.3 Flavivirus-like Superfamily ............................ 5 1.4 Picornavirus-like Viruses ............................. 6 1.5 Togavirus-like Superfamily ............................ 7 1.6 Nidovirales-like Viruses .............................. 8 2 TRAVIS - True Positive Details 9 2.1 INSnfrTABRAAPEI-14 .............................. 9 2.2 INSnfrTADRAAPEI-16 .............................. 10 2.3 INSnfrTAIRAAPEI-21 ............................... 11 2.4 INSnfrTAORAAPEI-35 .............................. 13 2.5 INSnfrTATRAAPEI-43 .............................. 14 2.6 INSnfrTBERAAPEI-19 .............................. 15 2.7 INSytvTABRAAPEI-11 .............................. 16 2.8 INSytvTALRAAPEI-35 .............................. 17 2.9 INSytvTBORAAPEI-47 .............................. 18 2.10 INSswpTBBRAAPEI-21 .............................. 19 2.11 INSeqtTAHRAAPEI-88 .............................. 20 2.12 INShkeTCLRAAPEI-44 .............................. 22 2.13 INSeqtTBNRAAPEI-11 .............................. 23 2.14 INSeqtTCJRAAPEI-20
    [Show full text]
  • Enteric and Non-Enteric Adenoviruses Associated with Acute Gastroenteritis in Pediatric Patients in Thailand, 2011 to 2017
    RESEARCH ARTICLE Enteric and non-enteric adenoviruses associated with acute gastroenteritis in pediatric patients in Thailand, 2011 to 2017 1,2 1,2 3,4 1,2 Kattareeya Kumthip , Pattara Khamrin , Hiroshi Ushijima , Niwat ManeekarnID * 1 Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 2 Center of Excellence in Emerging and Re-emerging Diarrheal Viruses, Chiang Mai University, Chiang Mai, Thailand, 3 Department of Developmental Medical Sciences, School of International Health, Graduate School of a1111111111 Medicine, The University of Tokyo, Tokyo, Japan, 4 Division of Microbiology, Department of Pathology and a1111111111 Microbiology, Nihon University School of Medicine, Tokyo, Japan a1111111111 * [email protected] a1111111111 a1111111111 Abstract Human adenovirus (HAdV) is known to be a common cause of diarrhea in children world- OPEN ACCESS wide. Infection with adenovirus is responsible for 2±10% of diarrheic cases. To increase a Citation: Kumthip K, Khamrin P, Ushijima H, better understanding of the prevalence and epidemiology of HAdV infection, a large scale Maneekarn N (2019) Enteric and non-enteric and long-term study was needed. We implemented a multi-year molecular detection and adenoviruses associated with acute gastroenteritis characterization study of HAdV in association with acute gastroenteritis in Chiang Mai, Thai- in pediatric patients in Thailand, 2011 to 2017. PLoS ONE 14(8): e0220263. https://doi.org/ land from 2011 to 2017. Out of 2,312 patients, HAdV was detected in 165 cases (7.2%). The 10.1371/journal.pone.0220263 positive rate for HAdV infection was highest in children of 1 and 2 years of age compared to Editor: Wenyu Lin, Harvard Medical School, other age groups.
    [Show full text]
  • Quito's Virome: Metagenomic Analysis of Viral Diversity in Urban Streams of Ecuador's Capital City
    Science of the Total Environment 645 (2018) 1334–1343 Contents lists available at ScienceDirect Science of the Total Environment journal homepage: www.elsevier.com/locate/scitotenv Quito's virome: Metagenomic analysis of viral diversity in urban streams of Ecuador's capital city Laura Guerrero-Latorre a,⁎, Brigette Romero a, Edison Bonifaz a, Natalia Timoneda b, Marta Rusiñol b, Rosina Girones b, Blanca Rios-Touma c a Grupo de investigación Biodiversidad, Medio Ambiente y Salud (BIOMAS), Facultad de Ingenierías y Ciencias Aplicadas (FICA), Ingeniería en Biotecnología, Universidad de las Américas, Quito, Ecuador b Laboratory of Virus Contaminants of Water and Food, Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Catalonia, Spain c Grupo de investigación Biodiversidad, Medio Ambiente y Salud (BIOMAS), Facultad de Ingenierías y Ciencias Aplicadas (FICA), Ingeniería Ambiental, Universidad de las Américas, Quito, Ecuador HIGHLIGHTS GRAPHICAL ABSTRACT • First viral metagomic study of highly impacted surface waters in Latin America • The study describes human viral patho- gens present in urban rivers of Quito. • Several viral families detected contain- ing emergent species firstly reported in Ecuador. article info abstract Article history: In Quito, the microbiological contamination of surface water represents a public health problem, mainly due to Received 25 May 2018 the lack of sewage treatment from urban wastewater. Contaminated water contributes to the transmission of Received in revised form 16 July 2018 many enteric pathogens through direct consumption, agricultural and recreational use. Among the different Accepted 16 July 2018 pathogens present in urban discharges, viruses play an important role on disease, being causes of gastroenteritis, Available online 23 July 2018 hepatitis, meningitis, respiratory infections, among others.
    [Show full text]
  • Viruses in Transplantation - Not Always Enemies
    Viruses in transplantation - not always enemies Virome and transplantation ECCMID 2018 - Madrid Prof. Laurent Kaiser Head Division of Infectious Diseases Laboratory of Virology Geneva Center for Emerging Viral Diseases University Hospital of Geneva ESCMID eLibrary © by author Conflict of interest None ESCMID eLibrary © by author The human virome: definition? Repertoire of viruses found on the surface of/inside any body fluid/tissue • Eukaryotic DNA and RNA viruses • Prokaryotic DNA and RNA viruses (phages) 25 • The “main” viral community (up to 10 bacteriophages in humans) Haynes M. 2011, Metagenomic of the human body • Endogenous viral elements integrated into host chromosomes (8% of the human genome) • NGS is shaping the definition Rascovan N et al. Annu Rev Microbiol 2016;70:125-41 Popgeorgiev N et al. Intervirology 2013;56:395-412 Norman JM et al. Cell 2015;160:447-60 ESCMID eLibraryFoxman EF et al. Nat Rev Microbiol 2011;9:254-64 © by author Viruses routinely known to cause diseases (non exhaustive) Upper resp./oropharyngeal HSV 1 Influenza CNS Mumps virus Rhinovirus JC virus RSV Eye Herpes viruses Parainfluenza HSV Measles Coronavirus Adenovirus LCM virus Cytomegalovirus Flaviviruses Rabies HHV6 Poliovirus Heart Lower respiratory HTLV-1 Coxsackie B virus Rhinoviruses Parainfluenza virus HIV Coronaviruses Respiratory syncytial virus Parainfluenza virus Adenovirus Respiratory syncytial virus Coronaviruses Gastro-intestinal Influenza virus type A and B Human Bocavirus 1 Adenovirus Hepatitis virus type A, B, C, D, E Those that cause
    [Show full text]
  • Mini Review Picobirnavirus: a Putative Emerging Threat to Humans And
    Advances in Animal and Veterinary Sciences Mini Review Picobirnavirus: A Putative Emerging Threat to Humans and Animals JOBIN JOSE KATTOOR, SHUBHANKAR SIRCAR, SHARAD SAURAB, SHANMUGANATHAN SUBRAMANIYAN, KULDEEP DHAMA, YASHPAL SINGH MALIK* ICAR-Indian Veterinary Research Institute, Izatnagar 243122, Bareilly, Uttar Pradesh, India. Abstract | Diarrheal diseases remain fatal threat to human and animal population with the emergence of new types of pathogens. Among them, viral gastroenteritis plays a lion share with a number ranging over 100 different types including emerging and re-emerging types of viruses. Recent viral metagenomics studies confirm the co-existence of viruses in gastrointestinal tract of several different host species. A Picobirnavirus, consisting of 2 segments, has recently attained attention due to its wide host range and genetic variability. Until 2011, these small viruses were not consid- ered as a separate virus family, when a new family (Picobirnaviridae) was approved by the International Committee on Taxonomy of Viruses (ICTV). Currently two distinct genogroups (GG-I and GG-II) and one predicted genogroup (GG-III) are included in the Picobirnaviridae family. Recently, picobirnavirus infections have been reported from al- most all species including wild animals where persistent infection of the virus is also reported. Picobirnaviruses (PBVs) are also reported as opportunistic pathogens in immuno compromised hosts including HIV infected patients. Presence of atypical picobirnaviruses with shorter genomic segments along with genetic closeness of animal and human PBVs and its ability to infect immuno-compromised hosts pose a heavy threat for all human and animal. Currently RNA dependent RNA polymerase based RT-PCR detection is considered as a rapid and sensitive method for detection of PBV.
    [Show full text]
  • Supporting Information
    Supporting Information Rosenberg et al. 10.1073/pnas.1307243110 SI Results and Discussion domestic ungulates (horses, cows, sheep, goats, camels, and pigs) Of the 83 arboviruses, nonhuman vertebrate hosts have been and rodents in both groups might be a consequence of spatial identified for 70 (84%); the remaining 13 are presumed to be proximity to humans. Sentinel monkeys were often used in pro- zoonoses because there is no indication they can be transmitted cedures to isolate arboviruses, which might account for their directly between humans by vectors (Table S1). Animal hosts have higher representation among arboviruses. In contrast, there are been identified for at least 57 (44%) of the 130 nonarboviruses; an few published records of bats being routinely sampled during additional 5 (8%) are presumed on epidemiological evidence to arbovirus studies, and only two arboviruses (3%) have been iso- have nonhuman reservoirs (Table S1). A number of viruses infect lated from bats. The reason a much larger number of arbovirus more than one nonhuman vertebrate host species and it is likely species (n = 16) have been isolated from birds than have that the variety of hosts is wider than has been recorded. The nonarbovirus species (n = 1) might, however, be characteristic of predominant host groups for arboviruses (n = 70) are nonhuman the pathogenicity of the togaviruses and flaviviruses, which are primates (31%), rodents (29%), ungulates (26%), and birds (23%); much more common among the arboviruses. The most prominent for the nonarboviruses (n = 57), they are rodents (30%), ungu- vectors of arboviruses were mosquitoes (67%), ticks (19%), and lates (26%), bats (23%), and primates (16%).
    [Show full text]
  • Near Full Length Genome of a Recombinant (E/D) Cosavirus Strain
    www.nature.com/scientificreports OPEN Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central Received: 26 February 2018 Accepted: 23 July 2018 region of Brazil Published: xx xx xxxx Antonio Charlys da Costa 1, Adriana Luchs 2, Flavio Augusto de Pádua Milagres3,4,5,6, Shirley Vasconcelos Komninakis7,8, Danielle Elise Gill1, Márcia Cristina Alves Brito Sayão Lobato4,6, Rafael Brustulin4,5,6, Rogério Togisaki das Chagas4,6, Maria de Fátima Neves dos Santos Abrão4,6, Cassia Vitória de Deus Alves Soares4,6, Xutao Deng9,10, Ester Cerdeira Sabino1,3, Eric Delwart9,10 & Élcio Leal 11 In the present article we report the nearly full length genome of a Cosavirus strain (BRTO-83) isolated from a child with acute gastroenteritis, and who is an inhabitant of a rural area in the central region of Brazil. The sample was previously screened and negative for both: common enteric viruses (i.e. rotavirus and norovirus), bacteria, endoparasites and helminthes. Evolutionary analysis and phylogenetic inferences indicated that the Brazilian BRTO-83 Cosavirus strain was a recombinant virus highly related to the E/D recombinant NG385 strain (Genbank JN867757), which was isolated in Nigeria from an acute faccid paralysis patient. This is the frst report of a recombinant E/D Cosavirus strain detected in Brazil, and the second genome described worldwide. Further surveillance and molecular studies are required to fully understand the epidemiology, distribution and evolution of the Cosavirus. Te family Picornaviridae has undergone a signifcant expansion in recent years, due principally to the identifca- tion of previously unknown picornaviruses by next-generation sequencing (NGS) of clinical and environmental samples.
    [Show full text]
  • Arenaviridae Astroviridae Filoviridae Flaviviridae Hantaviridae
    Hantaviridae 0.7 Filoviridae 0.6 Picornaviridae 0.3 Wenling red spikefish hantavirus Rhinovirus C Ahab virus * Possum enterovirus * Aronnax virus * * Wenling minipizza batfish hantavirus Wenling filefish filovirus Norway rat hunnivirus * Wenling yellow goosefish hantavirus Starbuck virus * * Porcine teschovirus European mole nova virus Human Marburg marburgvirus Mosavirus Asturias virus * * * Tortoise picornavirus Egyptian fruit bat Marburg marburgvirus Banded bullfrog picornavirus * Spanish mole uluguru virus Human Sudan ebolavirus * Black spectacled toad picornavirus * Kilimanjaro virus * * * Crab-eating macaque reston ebolavirus Equine rhinitis A virus Imjin virus * Foot and mouth disease virus Dode virus * Angolan free-tailed bat bombali ebolavirus * * Human cosavirus E Seoul orthohantavirus Little free-tailed bat bombali ebolavirus * African bat icavirus A Tigray hantavirus Human Zaire ebolavirus * Saffold virus * Human choclo virus *Little collared fruit bat ebolavirus Peleg virus * Eastern red scorpionfish picornavirus * Reed vole hantavirus Human bundibugyo ebolavirus * * Isla vista hantavirus * Seal picornavirus Human Tai forest ebolavirus Chicken orivirus Paramyxoviridae 0.4 * Duck picornavirus Hepadnaviridae 0.4 Bildad virus Ned virus Tiger rockfish hepatitis B virus Western African lungfish picornavirus * Pacific spadenose shark paramyxovirus * European eel hepatitis B virus Bluegill picornavirus Nemo virus * Carp picornavirus * African cichlid hepatitis B virus Triplecross lizardfish paramyxovirus * * Fathead minnow picornavirus
    [Show full text]
  • Evidence to Support Safe Return to Clinical Practice by Oral Health Professionals in Canada During the COVID-19 Pandemic: a Repo
    Evidence to support safe return to clinical practice by oral health professionals in Canada during the COVID-19 pandemic: A report prepared for the Office of the Chief Dental Officer of Canada. November 2020 update This evidence synthesis was prepared for the Office of the Chief Dental Officer, based on a comprehensive review under contract by the following: Paul Allison, Faculty of Dentistry, McGill University Raphael Freitas de Souza, Faculty of Dentistry, McGill University Lilian Aboud, Faculty of Dentistry, McGill University Martin Morris, Library, McGill University November 30th, 2020 1 Contents Page Introduction 3 Project goal and specific objectives 3 Methods used to identify and include relevant literature 4 Report structure 5 Summary of update report 5 Report results a) Which patients are at greater risk of the consequences of COVID-19 and so 7 consideration should be given to delaying elective in-person oral health care? b) What are the signs and symptoms of COVID-19 that oral health professionals 9 should screen for prior to providing in-person health care? c) What evidence exists to support patient scheduling, waiting and other non- treatment management measures for in-person oral health care? 10 d) What evidence exists to support the use of various forms of personal protective equipment (PPE) while providing in-person oral health care? 13 e) What evidence exists to support the decontamination and re-use of PPE? 15 f) What evidence exists concerning the provision of aerosol-generating 16 procedures (AGP) as part of in-person
    [Show full text]
  • Commission Directive (Eu)
    L 279/54 EN Offi cial Jour nal of the European Union 31.10.2019 COMMISSION DIRECTIVE (EU) 2019/1833 of 24 October 2019 amending Annexes I, III, V and VI to Directive 2000/54/EC of the European Parliament and of the Council as regards purely technical adjustments THE EUROPEAN COMMISSION, Having regard to the Treaty on the Functioning of the European Union, Having regard to Directive 2000/54/EC of the European Parliament and of the Council of 18 September 2000 on the protection of workers from risks related to exposure to biological agents at work (1), and in particular Article 19 thereof, Whereas: (1) Principle 10 of the European Pillar of Social Rights (2), proclaimed at Gothenburg on 17 November 2017, provides that every worker has the right to a healthy, safe and well-adapted working environment. The workers’ right to a high level of protection of their health and safety at work and to a working environment that is adapted to their professional needs and that enables them to prolong their participation in the labour market includes protection from exposure to biological agents at work. (2) The implementation of the directives related to the health and safety of workers at work, including Directive 2000/54/EC, was the subject of an ex-post evaluation, referred to as a REFIT evaluation. The evaluation looked at the directives’ relevance, at research and at new scientific knowledge in the various fields concerned. The REFIT evaluation, referred to in the Commission Staff Working Document (3), concludes, among other things, that the classified list of biological agents in Annex III to Directive 2000/54/EC needs to be amended in light of scientific and technical progress and that consistency with other relevant directives should be enhanced.
    [Show full text]
  • Persistent Human Cosavirus Infection in Lung Transplant Recipient, Italy
    HCoSV-positive patients were co-infected with other gas- Persistent Human troenteric viruses. Kapusinszky et al. recently conducted phylogenetic analysis of viral protein (VP) 3–VP1 genes, Cosavirus Infection which revealed greater genetic variability of HCoSV strains, and proposed splitting species A into 24 species (A1–A24), in Lung Transplant D into 5 species (D1–D5), E into 2 species (E1–E2), and Recipient, Italy classifying F as 1 species (6). We report a case of HCoSV infection in an immuno- Giulia Campanini, Francesca Rovida, compromised woman in northern Italy and the results of Federica Meloni, Alessandro Cascina, retrospective HCoSV testing of 689 stored fecal samples Rachele Ciccocioppo, Antonio Piralla, from hospitalized patients with gastrointestinal signs and and Fausto Baldanti symptoms. The study was performed according to guide- lines of the institutional review board of the Fondazione Human cosavirus is a novel picornavirus recently Istituto Di Ricovero e Cura a Carattere Scientifico Poli- identified in feces from children in southern Asia. We report clinico, San Matteo, Pavia, Italy, on the use of biological infection with human cosavirus in a patient in the Mediterra- specimens for scientific purposes in keeping with Italian nean area. The patient was an adult double lung transplant law (Article 13 D.Lgs 196/2003) and after having obtained recipient who had chronic diarrhea associated with persis- tent infection with human cosavirus. written informed consent from the patient. The Study n 2008, a new virus was detected in fecal samples from In 2003, a 43-year-old white woman who had under- Ichildren with nonpolio acute flaccid paralysis (1).
    [Show full text]
  • Multipartite Viruses: Organization, Emergence and Evolution
    UNIVERSIDAD AUTÓNOMA DE MADRID FACULTAD DE CIENCIAS DEPARTAMENTO DE BIOLOGÍA MOLECULAR MULTIPARTITE VIRUSES: ORGANIZATION, EMERGENCE AND EVOLUTION TESIS DOCTORAL Adriana Lucía Sanz García Madrid, 2019 MULTIPARTITE VIRUSES Organization, emergence and evolution TESIS DOCTORAL Memoria presentada por Adriana Luc´ıa Sanz Garc´ıa Licenciada en Bioqu´ımica por la Universidad Autonoma´ de Madrid Supervisada por Dra. Susanna Manrubia Cuevas Centro Nacional de Biotecnolog´ıa (CSIC) Memoria presentada para optar al grado de Doctor en Biociencias Moleculares Facultad de Ciencias Departamento de Biolog´ıa Molecular Universidad Autonoma´ de Madrid Madrid, 2019 Tesis doctoral Multipartite viruses: Organization, emergence and evolution, 2019, Madrid, Espana. Memoria presentada por Adriana Luc´ıa-Sanz, licenciada en Bioqumica´ y con un master´ en Biof´ısica en la Universidad Autonoma´ de Madrid para optar al grado de doctor en Biociencias Moleculares del departamento de Biolog´ıa Molecular en la facultad de Ciencias de la Universidad Autonoma´ de Madrid Supervisora de tesis: Dr. Susanna Manrubia Cuevas. Investigadora Cient´ıfica en el Centro Nacional de Biotecnolog´ıa (CSIC), C/ Darwin 3, 28049 Madrid, Espana. to the reader CONTENTS Acknowledgments xi Resumen xiii Abstract xv Introduction xvii I.1 What is a virus? xvii I.2 What is a multipartite virus? xix I.3 The multipartite lifecycle xx I.4 Overview of this thesis xxv PART I OBJECTIVES PART II METHODOLOGY 0.5 Database management for constructing the multipartite and segmented datasets 3 0.6 Analytical
    [Show full text]