Age-depended Selection of Chloroquine- sensitive Plasmodium Falciparum in Some part of Central Region of Ghana Kwame Kumi Asare (
[email protected] ) University of Cape Coast https://orcid.org/0000-0002-5219-763X Justice Afrifa University of Cape Coast Kwaku Opoku Yeboah University of Education Winneba Research Keywords: P. falciparum, chloroquine resistance parasites, chloroquine sensitive parasites, Pfcrt, Pfmdr1, Central Region, Ghana Posted Date: February 18th, 2021 DOI: https://doi.org/10.21203/rs.3.rs-208111/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License 1 2 3 Age-depended selection of chloroquine-sensitive Plasmodium falciparum in some part of Central 4 Region of Ghana 5 6 1* 2 3 7 Kwame Kumi Asare , Justice Afrifa , Yeboah Kwaku Opoku 8 9 1 Department of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied 10 11 Sciences, University of Cape Coast, Cape Coast, Ghana 12 13 2 14 Department of Medical Laboratory Science, University of Cape Coast, Cape Coast, Ghana 15 16 3 Department of Biology Education, Faculty of Science Education, University of Education, Winneba, 17 18 Ghana 19 20 21 *Corresponding author 22 23 24 25 Abstract 26 27 Introduction 28 29 30 The return of chloroquine-sensitive P. falciparum in sub-Saharan Africa countries offers the 31 32 opportunity for reintroduction of chloroquine either in combination with other drugs or as a single 33 therapy for the management of malaria. The reintroduction of chloroquine can serve as a stopgap to 34 salvage the impending danger of complete failure of malaria treatment due to artemisinin drug 35 36 resistance.