viruses Article Potent and Selective Activity against Human Immunodeficiency Virus 1 (HIV-1) of Thymelaea hirsuta Extracts 1, , 1, 2 1 Giuseppina Sanna * y , Silvia Madeddu y , Giuseppe Murgia , Gabriele Serreli , Michela Begala 3 , Pierluigi Caboni 3 , Alessandra Incani 1, Gianluigi Franci 4 , Marilena Galdiero 5 and Gabriele Giliberti 1 1 Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, 09042 Cagliari, Italy;
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[email protected] (G.G.) 2 Department of Inorganic and Analytical Chemistry, University of Cagliari, Cittadella Universitaria, Monserrato, 09042 Cagliari, Italy;
[email protected] 3 Department of Life and Environmental Sciences-Unit of Drug Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, 09042 Cagliari, Italy;
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[email protected] (P.C.) 4 Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy;
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[email protected] These authors equally contributed to this work. y Received: 20 May 2020; Accepted: 16 June 2020; Published: 19 June 2020 Abstract: Historically, natural products have been the most successful source of inspiration for the development of new drugs. Members of the Thymelaeaceae family have been of interest owing to their excellent medicinal value. Given the successful history of natural product-based drug discovery, extracts from the aerial parts of Thymelaea hirsuta were evaluated for their potential anti-human immunodeficiency virus type 1 (HIV-1) activity.