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International Journal of Scientific Research and Reviews
Saha Sudipta, IJSRR 2018, 7(3), 1749-1768 Review article Available online www.ijsrr.org ISSN: 2279–0543 International Journal of Scientific Research and Reviews Novel Antitussive Agents from Natural Source-A Review Saha Sudipta* Assistant Professor, Department of Chemistry, TrivenideviBhalotia College, Raniganj, PaschimBardhaman, West-Bengal, India, Pin-713347 Email: [email protected]; Mobile No:-+91-94343486121 ABSTRACT Cough, acts as the defender of the foreign materials and secretions from the airways. Cough gives the protection of the lungs and distal parts of airways from chocking and infected mucus. Cough is one of the major worldwide problem as patients suffering from this visit physician. In this way it leads to the economical problem in the society. The mostly used and available antitussive agents in the markets are codeine and dextromethorphan. Although they are good cough suppressing but they have also numerous side effects e.g., sedation, nausea, addictive potential, and constipation. Although a new class of antitussive drugs are not coming into the market for a long time. To solve this problem pharmacists and researchers are searching novel, less toxic, more effective antitussive drugs from the nature. Plant derived medicines act as the supplementary to the synthetic drugs followed by engineered protein and gene therapy. In this context pharmacotherapy provides some novel alkaloids, triterpenoids, phenolglycosides, polysaccharides, flavonoids, as more effective and less toxic antitussive agents. These said phytochemicals isolated from botanical source play a major role in the treatment of many respiratory diseases including cough. Some of the above mentioned extracts from the shrubs are used in the Indian traditional medicine, they can be used as a safe antitussive agents. -
Classical Recreational Drugs New Psychoactive Substances
. Euro-DEN Plus: 2013-2017 . 23,947 presentations Classical Recreational Drugs and New Psychoactive Substances Professor Paul I Dargan Guy’s and St Thomas’ NHS Foundation Trust and King’s College London London, UK “Classical Drugs” Classification Stimulants Depressants MDMA (ecstasy) Opioids Amphetamine Benzodiazepines Cocaine GHB/GBL/1,4BD Hallucinogenics LSD Ketamine 1 Opioid Antagonist – Naloxone GHB and its Analogues GBL / 1,4BD . Competitive opioid antagonist – Onset 1-2 minutes, duration 30-90 minutes . Give in titrated 100 – 200 micrograms doses . Naloxone should be given IV – Can be given IM if no IV access . Aim to restore normal oxygenation/improve alertness . Infusion if long-acting preparation / features recur – Initial hourly dose of infusion is 2/3 of initial dose . What additional test is important in everyone with opioid toxicity? Paracetamol concentration . Ingestion of all 3 causes similar clinical features Effects of GHB / GBL Management of acute GHB/GBL toxicity 1-2mL . Mild-Moderate: – relaxation, appreciation for music & dancing, euphoria . Supportive care: ABC and monitoring – nausea, tremor, diarrhoea, agitation . Coma normally lasts 1-3 hours 3-4mL . Severe: . Airway reflexes generally well maintained – Increasing drowsiness …. coma, convulsions, respiratory depression, . Need for intubation: bradycardia – Not usually indicated if maintaining airway, no vomiting NB. Vomiting in 15-20%, convulsions in <10% . Think about dependence / risk of withdrawal in those with acute toxicity 3-6mL . Deaths: – Mostly pre-hospital, related to aspiration How many have seen a patient with this? 2 GHB Dependence/Withdrawal Acute Stimulant Toxicity . GHB: GABA-B agonist, also upregulates dopamine . Agitation and aggression, psychosis . Very frequent use: 1-2 hourly including overnight . -
Genl:VE 1970 © World Health Organization 1970
Nathan B. Eddy, Hans Friebel, Klaus-Jiirgen Hahn & Hans Halbach WORLD HEALTH ORGANIZATION ORGANISATION .MONDIALE DE LA SANT~ GENl:VE 1970 © World Health Organization 1970 Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. Nevertheless governmental agencies or learned and professional societies may reproduce data or excerpts or illustrations from them without requesting an authorization from the World Health Organization. For rights of reproduction or translation of WHO publications in toto, application should be made to the Division of Editorial and Reference Services, World Health Organization, Geneva, Switzerland. The World Health Organization welcomes such applications. Authors alone are responsible for views expressed in signed articles. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Director-General of the World Health Organization concerning the legal status of any country or territory or of its authorities, or concerning the delimitation of its frontiers. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. © Organisation mondiale de la Sante 1970 Les publications de l'Organisation mondiale de la Sante beneficient de la protection prevue par les dispositions du Protocole n° 2 de la Convention universelle pour la Protection du Droit d'Auteur. Les institutions gouvernementales et les societes savantes ou professionnelles peuvent, toutefois, reproduire des donnees, des extraits ou des illustrations provenant de ces publications, sans en demander l'autorisation a l'Organisation mondiale de la Sante. Pour toute reproduction ou traduction integrate, une autorisation doit etre demandee a la Division des Services d'Edition et de Documentation, Organisation mondiale de la Sante, Geneve, Suisse. -
EUROPEAN COMMISSION Brussels, 11.7.2011 SEC(2011)
EUROPEAN COMMISSION Brussels, 11.7.2011 SEC(2011) 912 final COMMISSION STAFF WORKING PAPER on the assessment of the functioning of Council Decision 2005/387/JHA on the information exchange, risk assessment and control of new psychoactive substances Accompanying the document REPORT FROM THE COMMISSION on the assessment of the functioning of Council Decision 2005/387/JHA on the information exchange, risk assessment and control of new psychoactive substances {COM(2011) 430 final} EN EN TABLE OF CONTENTS 1. Introduction...................................................................................................................3 2. Methodology.................................................................................................................4 3. Key findings from the 2002 evaluation of the Joint Action on synthetic drugs ...........5 4. Overview of notifications, types of substances and trends at EU level 2005-2010......7 5. Other EU legislation relevant for the regulation of new psychoactive substances.....12 6. Functioning of the Council Decision on new psychoactive substances .....................16 7. Findings of the survey among Member States............................................................17 7.1. Assessment of the Council Decision ..........................................................................17 7.2. Stages in the functioning of the Council Decision .....................................................18 7.3. National responses to new psychoactive substances ..................................................20 -
Pharmacology on Your Palms CLASSIFICATION of the DRUGS
Pharmacology on your palms CLASSIFICATION OF THE DRUGS DRUGS FROM DRUGS AFFECTING THE ORGANS CHEMOTHERAPEUTIC DIFFERENT DRUGS AFFECTING THE NERVOUS SYSTEM AND TISSUES DRUGS PHARMACOLOGICAL GROUPS Drugs affecting peripheral Antitumor drugs Drugs affecting the cardiovascular Antimicrobial, antiviral, Drugs affecting the nervous system Antiallergic drugs system antiparasitic drugs central nervous system Drugs affecting the sensory Antidotes nerve endings Cardiac glycosides Antibiotics CNS DEPRESSANTS (AFFECTING THE Antihypertensive drugs Sulfonamides Analgesics (opioid, AFFERENT INNERVATION) Antianginal drugs Antituberculous drugs analgesics-antipyretics, Antiarrhythmic drugs Antihelminthic drugs NSAIDs) Local anaesthetics Antihyperlipidemic drugs Antifungal drugs Sedative and hypnotic Coating drugs Spasmolytics Antiviral drugs drugs Adsorbents Drugs affecting the excretory system Antimalarial drugs Tranquilizers Astringents Diuretics Antisyphilitic drugs Neuroleptics Expectorants Drugs affecting the hemopoietic system Antiseptics Anticonvulsants Irritant drugs Drugs affecting blood coagulation Disinfectants Antiparkinsonian drugs Drugs affecting peripheral Drugs affecting erythro- and leukopoiesis General anaesthetics neurotransmitter processes Drugs affecting the digestive system CNS STIMULANTS (AFFECTING THE Anorectic drugs Psychomotor stimulants EFFERENT PART OF THE Bitter stuffs. Drugs for replacement therapy Analeptics NERVOUS SYSTEM) Antiacid drugs Antidepressants Direct-acting-cholinomimetics Antiulcer drugs Nootropics (Cognitive -
UNIVERSITE DE NANTES Thomas Gelineau
UNIVERSITE DE NANTES __________ FACULTE DE MEDECINE __________ Année 2011 N° 139 THESE pour le DIPLÔME D’ÉTAT DE DOCTEUR EN MÉDECINE DES de médecine générale par Thomas Gelineau né le 29 janvier 1983 à Cholet __________ Présentée et soutenue publiquement le 06/12/2011 __________ LE RHUME DE L'ENFANT ET SON TRAITEMENT: DECISION PARTAGEE AVEC LES PARENTS D'APRES UN QUESTIONNAIRE __________ Président : Monsieur le Professeur Olivier MALARD Directeur de thèse : Madame le Professeur Jacqueline LACAILLE 1 Table des matières IIntroduction................................................................................................................ 7 IIDéfinition, état des connaissances...........................................................................8 1Le rhume.......................................................................................................................................8 APhysiopathologie............................................................................................................................. 8 aL'origine virale.................................................................................................................................... 8 bLa saisonnalité................................................................................................................................... 8 cL'âge de survenue.............................................................................................................................. 9 dLe sexe.................................................................................................................................................. -
Morphological Description and New Record of Panaeolus Acuminatus (Agaricales) in Brazil
Studies in Fungi 4(1): 135–141 (2019) www.studiesinfungi.org ISSN 2465-4973 Article Doi 10.5943/sif/4/1/16 Morphological description and new record of Panaeolus acuminatus (Agaricales) in Brazil Xavier MD1, Silva-Filho AGS2, Baseia IG3 and Wartchow F4 1 Curso de Graduação em Ciências Biológicas, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Av. Senador Salgado Filho, 3000, Campus Universitário, 59072-970, Natal, RN, Brazil 2 Programa de Pós-Graduação em Sistemática e Evolução, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Av. Senador Salgado Filho, 3000, Campus Universitário, 59072-970, Natal, RN, Brazil 3 Departamento de Botânica e Zoologia, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Av. Senador Salgado Filho, 3000, Campus Universitário, 59072-970, Natal, RN, Brazil 4 Departamento de Sistemática e Ecologia, Universidade Federal da Paraíba, Conj. Pres. Castelo Branco III, 58033- 455, João Pessoa, PB, Brazil Xavier MD, Silva-Filho AGS, Baseia IG, Wartchow F 2019 – Morphological description and new record of Panaeolus acuminatus (Agaricales) in Brazil. Studies in Fungi 4(1), 135–141, Doi 10.5943/sif/4/1/16 Abstract Panaeolus acuminatus is described and illustrated based on fresh specimens collected from Northeast Brazil. This is the second known report of this species for the country, since it was already reported in 1930 by Rick. The species is characterized by the acuminate, pileus with hygrophanous surface, basidiospores measuring 11.5–16 × 5.5–11 µm and slender, non-capitate cheilocystidia. A full description accompanies photographs, line drawings and taxonomic discussion. Key words – Agaricomycotina – Basidiomycota – biodiversity – dark-spored – Panaeoloideae – Rick Introduction Species of Panaeolus (Fr.) Quél. -
Chemical Elements in Ascomycetes and Basidiomycetes
Chemical elements in Ascomycetes and Basidiomycetes The reference mushrooms as instruments for investigating bioindication and biodiversity Roberto Cenci, Luigi Cocchi, Orlando Petrini, Fabrizio Sena, Carmine Siniscalco, Luciano Vescovi Editors: R. M. Cenci and F. Sena EUR 24415 EN 2011 1 The mission of the JRC-IES is to provide scientific-technical support to the European Union’s policies for the protection and sustainable development of the European and global environment. European Commission Joint Research Centre Institute for Environment and Sustainability Via E.Fermi, 2749 I-21027 Ispra (VA) Italy Legal Notice Neither the European Commission nor any person acting on behalf of the Commission is responsible for the use which might be made of this publication. Europe Direct is a service to help you find answers to your questions about the European Union Freephone number (*): 00 800 6 7 8 9 10 11 (*) Certain mobile telephone operators do not allow access to 00 800 numbers or these calls may be billed. A great deal of additional information on the European Union is available on the Internet. It can be accessed through the Europa server http://europa.eu/ JRC Catalogue number: LB-NA-24415-EN-C Editors: R. M. Cenci and F. Sena JRC65050 EUR 24415 EN ISBN 978-92-79-20395-4 ISSN 1018-5593 doi:10.2788/22228 Luxembourg: Publications Office of the European Union Translation: Dr. Luca Umidi © European Union, 2011 Reproduction is authorised provided the source is acknowledged Printed in Italy 2 Attached to this document is a CD containing: • A PDF copy of this document • Information regarding the soil and mushroom sampling site locations • Analytical data (ca, 300,000) on total samples of soils and mushrooms analysed (ca, 10,000) • The descriptive statistics for all genera and species analysed • Maps showing the distribution of concentrations of inorganic elements in mushrooms • Maps showing the distribution of concentrations of inorganic elements in soils 3 Contact information: Address: Roberto M. -
Bulk Isolation of Basidiospores from Wild Mushrooms by Electrostatic Attraction with Low Risk of Microbial Contaminations Kiran Lakkireddy1,2 and Ursula Kües1,2*
Lakkireddy and Kües AMB Expr (2017) 7:28 DOI 10.1186/s13568-017-0326-0 ORIGINAL ARTICLE Open Access Bulk isolation of basidiospores from wild mushrooms by electrostatic attraction with low risk of microbial contaminations Kiran Lakkireddy1,2 and Ursula Kües1,2* Abstract The basidiospores of most Agaricomycetes are ballistospores. They are propelled off from their basidia at maturity when Buller’s drop develops at high humidity at the hilar spore appendix and fuses with a liquid film formed on the adaxial side of the spore. Spores are catapulted into the free air space between hymenia and fall then out of the mushroom’s cap by gravity. Here we show for 66 different species that ballistospores from mushrooms can be attracted against gravity to electrostatic charged plastic surfaces. Charges on basidiospores can influence this effect. We used this feature to selectively collect basidiospores in sterile plastic Petri-dish lids from mushrooms which were positioned upside-down onto wet paper tissues for spore release into the air. Bulks of 104 to >107 spores were obtained overnight in the plastic lids above the reversed fruiting bodies, between 104 and 106 spores already after 2–4 h incubation. In plating tests on agar medium, we rarely observed in the harvested spore solutions contamina- tions by other fungi (mostly none to up to in 10% of samples in different test series) and infrequently by bacteria (in between 0 and 22% of samples of test series) which could mostly be suppressed by bactericides. We thus show that it is possible to obtain clean basidiospore samples from wild mushrooms. -
Glaucine Inhibits Breast Cancer Cell Migration and Invasion by Inhibiting MMP-9 Gene Expression Through the Suppression of NF-Jb Activation
Mol Cell Biochem DOI 10.1007/s11010-015-2339-9 Glaucine inhibits breast cancer cell migration and invasion by inhibiting MMP-9 gene expression through the suppression of NF-jB activation Hyereen Kang • Sung-Wuk Jang • Jhang Ho Pak • Sungbo Shim Received: 14 November 2014 / Accepted: 30 January 2015 Ó The Author(s) 2015. This article is published with open access at Springerlink.com Abstract Matrix metalloproteinase-9 (MMP-9) plays a useful as a novel means of controlling breast cancer growth central role in the invasion and metastasis of various types and invasiveness. of cancer cells. Here, we demonstrate that glaucine, an al- kaloid isolated from the plant Corydalis turtschaninovii Keywords Invasion Á Migration Á MMPs Á Natural tuber (Papaveraceae), can inhibit the migration and invasion compound Á Breast cancer of human breast cancer cells. We further show that glaucine significantly blocks phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression and activity in a dose- Introduction dependent manner. Results from reporter gene and elec- trophoretic mobility shift assays revealed that glaucine in- Metastasis is a defining characteristic of malignant cancer hibits MMP-9 expression by suppressing activation of the cells, and uncontrolled metastasis is the leading cause of death nuclear transcription factor nuclear factor-jB (NF-jB). in patients with cancer. Metastasis is a multi-step process in- Moreover, glaucine attenuates PMA-induced IjBa degra- volving degradation of the extracellular matrix (ECM), ad- dation and nuclear translocation of NF-jB. Finally, we also hesion of cancer cells to endothelial cells, extravasation found that glaucine inhibits invasion and MMP-9 expres- leading to infiltration of the underlying tissue, and metastatic sion in the highly metastatic MDA-MB-231 breast cancer foci formation [1, 2]. -
Part I: Synthesis of Functionalized Bile Acids Towards The
PART I: SYNTHESIS OF FUNCTIONALIZED BILE ACIDS TOWARDS THE CONSTRUCTION OF STEROIDAL MACROCYCLES. PART II: EVALUATION AND EXPANSION OF A MODULAR CARD GAME FOR TEACHING ORGANIC CHEMISTRY A DISSERTATION IN Chemistry and Pharmaceutical Sciences Presented to the Faculty of the University of Missouri-Kansas City in partial fulfillment of the requirements for the degree DOCTOR OF PHILOSOPHY by CHRISTOPHER ANTON KNUDTSON B.S., Saint Louis University 2004 M.S., Kansas University 2011 Kansas City, Missouri 2019 © 2019 CHRISTOPHER ANTON KNUDTSON ALL RIGHTS RESERVED PART I: SYNTHESIS OF FUNCTIONALIZED BILE ACIDS TOWARDS THE CONSTRUCTION OF STEROIDAL MACROCYCLES. PART II: EVALUATION AND EXPANSION OF A MODULAR CARD GAME FOR TEACHING ORGANIC CHEMISTRY Christopher A. Knudtson, Candidate for the Doctor of Philosophy Degree University of Missouri-Kansas City, 2019 ABSTRACT In Part I, the synthesis of chenodeoxychoic acid (CDCA) derivatives towards the construction of unique chemical architectures are reported. Building on previously described methods, CDCA based macrocycles with inner cavities have been synthesized and characterized. Attempts toward oxa-Michael coupling of CDCA monomers to form sulfonate ester linked dimmers is described. CDCA was also functionalized with terminal alkynes (pentynyl, hexynyl, and heptynyl) and aryl iodide and cyclized to from the respective macrocycles. These have been coupled together via oxygen-free Sonogashira reaction conditions to form large barrel-like steroidal architectures. These structures were investigated by 1H NMR, 13 C NMR spectroscopy, and HR-MS, and MALDI-TOF spectroscopy. In part II a game to teach organic chemistry, ChemKarta was evaluated as a teaching tool. Analysis of an undergraduate class’s impressions of the game showed that Chemkarta was an easy to learn and enjoyable game, but the amount of information in the game could be overwhelming for some students. -
Appendix-2Final.Pdf 663.7 KB
North West ‘Through the Gate Substance Misuse Services’ Drug Testing Project Appendix 2 – Analytical methodologies Overview Urine samples were analysed using three methodologies. The first methodology (General Screen) was designed to cover a wide range of analytes (drugs) and was used for all analytes other than the synthetic cannabinoid receptor agonists (SCRAs). The analyte coverage included a broad range of commonly prescribed drugs including over the counter medications, commonly misused drugs and metabolites of many of the compounds too. This approach provided a very powerful drug screening tool to investigate drug use/misuse before and whilst in prison. The second methodology (SCRA Screen) was specifically designed for SCRAs and targets only those compounds. This was a very sensitive methodology with a method capability of sub 100pg/ml for over 600 SCRAs and their metabolites. Both methodologies utilised full scan high resolution accurate mass LCMS technologies that allowed a non-targeted approach to data acquisition and the ability to retrospectively review data. The non-targeted approach to data acquisition effectively means that the analyte coverage of the data acquisition was unlimited. The only limiting factors were related to the chemical nature of the analyte being looked for. The analyte must extract in the sample preparation process; it must chromatograph and it must ionise under the conditions used by the mass spectrometer interface. The final limiting factor was presence in the data processing database. The subsequent study of negative MDT samples across the North West and London and the South East used a GCMS methodology for anabolic steroids in addition to the General and SCRA screens.